Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cell morphogenesis	AUTS2 LAMA5 SPART DIP2B EIF2AK4 MYCBP2 PLXNA2 ZMYM3 IGHM RAC3	1.49e-05	1194	34	10	GO:0000902
GeneOntologyBiologicalProcess	peripheral B cell selection	IGHM BTK	1.58e-05	4	34	2	GO:0002343
GeneOntologyBiologicalProcess	B cell affinity maturation	IGHM BTK	1.58e-05	4	34	2	GO:0002344
GeneOntologyBiologicalProcess	axonogenesis	AUTS2 LAMA5 SPART DIP2B MYCBP2 PLXNA2 RAC3	3.19e-05	566	34	7	GO:0007409
GeneOntologyBiologicalProcess	neuron projection morphogenesis	AUTS2 LAMA5 SPART DIP2B EIF2AK4 MYCBP2 PLXNA2 RAC3	3.73e-05	802	34	8	GO:0048812
GeneOntologyBiologicalProcess	B cell selection	IGHM BTK	3.94e-05	6	34	2	GO:0002339
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	AUTS2 LAMA5 SPART DIP2B EIF2AK4 MYCBP2 PLXNA2 RAC3	4.33e-05	819	34	8	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	AUTS2 LAMA5 SPART DIP2B EIF2AK4 MYCBP2 PLXNA2 RAC3	4.59e-05	826	34	8	GO:0048858
GeneOntologyBiologicalProcess	axon development	AUTS2 LAMA5 SPART DIP2B MYCBP2 PLXNA2 RAC3	7.08e-05	642	34	7	GO:0061564
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	AUTS2 LAMA5 SPART DIP2B MYCBP2 PLXNA2 RAC3	1.83e-04	748	34	7	GO:0048667
GeneOntologyBiologicalProcess	phagocytosis, engulfment	ITGAM ABCA7 RAC3	1.99e-04	69	34	3	GO:0006911
GeneOntologyBiologicalProcess	engulfment of apoptotic cell	ABCA7 RAC3	2.73e-04	15	34	2	GO:0043652
GeneOntologyBiologicalProcess	plasma membrane invagination	ITGAM ABCA7 RAC3	2.86e-04	78	34	3	GO:0099024
GeneOntologyBiologicalProcess	membrane invagination	ITGAM ABCA7 RAC3	3.95e-04	87	34	3	GO:0010324
GeneOntologyBiologicalProcess	cell-substrate adhesion	LAMA5 PLG ITGAM MADCAM1 RAC3	5.24e-04	410	34	5	GO:0031589
GeneOntologyBiologicalProcess	developmental growth	AUTS2 SPART BBS2 DIP2B EIF2AK4 PLG MYCBP2	6.05e-04	911	34	7	GO:0048589
Domain	FG-GAP	BBS2 ITGAM	8.66e-04	24	34	2	PF01839
Domain	FG-GAP	BBS2 ITGAM	8.66e-04	24	34	2	IPR013517
Domain	Ig-like_fold	LRFN1 HMCN1 MYCBP2 MADCAM1 PLXNA2 IGHM	1.55e-03	706	34	6	IPR013783
Domain	-	LRFN1 HMCN1 MYCBP2 MADCAM1 PLXNA2	6.58e-03	663	34	5	2.60.40.10
Pubmed	Bruton's Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae.	IGHM BTK	9.84e-07	2	35	2	35537415
Pubmed	Cohort of Iranian Patients with Congenital Agammaglobulinemia: Mutation Analysis and Novel Gene Defects.	IGHM BTK	9.84e-07	2	35	2	26910880
Pubmed	Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2.	PLG ITGAM	2.95e-06	3	35	2	18714035
Pubmed	An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity.	IGHM BTK	2.95e-06	3	35	2	16301620
Pubmed	Fatal disseminated mouse adenovirus type 1 infection in mice lacking B cells or Bruton's tyrosine kinase.	IGHM BTK	5.90e-06	4	35	2	15140955
Pubmed	A differentiation pathway for B1 cells in adult bone marrow.	IGHM BTK	5.90e-06	4	35	2	19307589
Pubmed	Integrin alphaMbeta2 orchestrates and accelerates plasminogen activation and fibrinolysis by neutrophils.	PLG ITGAM	5.90e-06	4	35	2	14769799
Pubmed	Complement factor H-binding protein, a putative virulence determinant of Borrelia hermsii, is an antigenic target for protective B1b lymphocytes.	IGHM BTK	5.90e-06	4	35	2	18354209
Pubmed	Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement.	IGHM BTK	5.90e-06	4	35	2	16585544
Pubmed	The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.	IGHM BTK	9.82e-06	5	35	2	12646649
Pubmed	Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.	IGHM BTK	9.82e-06	5	35	2	19214191
Pubmed	Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.	LAMA5 DIP2B	9.82e-06	5	35	2	20972440
Pubmed	Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models.	IGHM BTK	9.82e-06	5	35	2	23885715
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 LAMA5 LRFN1 SRCAP MYCBP2 PPRC1 ABCA7 EIF2B3	1.11e-05	1105	35	8	35748872
Pubmed	Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138+ Cells.	IGHM BTK	1.47e-05	6	35	2	29661828
Pubmed	Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands.	IGHM BTK	1.47e-05	6	35	2	25053811
Pubmed	Systemic cancer therapy with engineered adenovirus that evades innate immunity.	ITGAM IGHM	2.06e-05	7	35	2	33239388
Pubmed	Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.	IVL ABCA7	2.74e-05	8	35	2	24293640
Pubmed	Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1.	IGHM BTK	2.74e-05	8	35	2	12634786
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	LAMA5 PLG HMCN1 PLXNA2	2.87e-05	175	35	4	28071719
Pubmed	Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice.	ITGAM IGHM	3.53e-05	9	35	2	8552190
Pubmed	A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.	PLG ITGAM	5.38e-05	11	35	2	26647393
Pubmed	Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.	IVL LAMA5	7.62e-05	13	35	2	9670011
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	LAMA5 PLG HMCN1 ITGAM KRT36 IGHM RAC3	8.09e-05	1070	35	7	23533145
Pubmed	Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity.	ITGAM MADCAM1	8.89e-05	14	35	2	23601687
Pubmed	Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays.	SPART KRT36 BTK	9.34e-05	87	35	3	20804422
Pubmed	Ontogeny of stromal organizer cells during lymph node development.	LAMA5 MADCAM1	1.17e-04	16	35	2	20237296
Pubmed	Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.	LAMA5 DIP2B	1.33e-04	17	35	2	24737748
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	LAMA5 ITGAM	1.49e-04	18	35	2	39040056
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	LAMA5 SPART PPRC1	1.63e-04	105	35	3	9628581
Pubmed	Multiple roles of lymphatic vessels in peripheral lymph node development.	LAMA5 MADCAM1	1.85e-04	20	35	2	30355615
Pubmed	Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.	LAMA5 ITGAM	2.24e-04	22	35	2	28334989
Pubmed	Antibodies and complement are key drivers of thrombosis.	ITGAM IGHM	2.46e-04	23	35	2	39226900
Pubmed	WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.	IVL KRT36	2.68e-04	24	35	2	28589954
Pubmed	Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.	LAMA5 ITGAM	2.91e-04	25	35	2	19373938
Pubmed	Functional proteomics mapping of a human signaling pathway.	ABTB1 LAMA5 SPART MYCBP2 SOX13	2.97e-04	591	35	5	15231748
Pubmed	Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.	PLXNA2 RAC3	3.15e-04	26	35	2	39152101
Pubmed	Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.	AUTS2 PLXNA2	3.66e-04	28	35	2	33953184
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF462 AUTS2 SOX13 ZMYM3	4.17e-04	351	35	4	38297188
Pubmed	Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.	ITGAM IGHM	4.49e-04	31	35	2	25645918
Pubmed	Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.	IVL ITGAM	4.49e-04	31	35	2	20930145
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	IVL LAMA5	4.49e-04	31	35	2	22274697
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF462 AUTS2 HIVEP3 DIP2B EIF2AK4 MYCBP2 ATXN7L1	6.09e-04	1489	35	7	28611215
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	LAMA5 PLG HMCN1	6.36e-04	167	35	3	22159717
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	LAMA5 ITGAM	6.41e-04	37	35	2	34323105
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF462 ZCCHC4 DIP2B SRCAP MYCBP2 ZMYM3	6.70e-04	1082	35	6	38697112
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	IVL LAMA5 PLG IGHM	7.95e-04	417	35	4	19199708
Pubmed	Bioinformatics and cellular signaling.	PPRC1 BTK RAC3	8.16e-04	182	35	3	15102471
Interaction	NRF1 interactions	AUTS2 BBS2 C10orf55 PPRC1	1.40e-05	85	35	4	int:NRF1
Coexpression	GSE20715_WT_VS_TLR4_KO_LUNG_DN	LAMA5 BBS2 MYCBP2 ABCA7 IGHM	6.47e-06	199	35	5	M4350
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_naive\|lymph-node_spleen / Manually curated celltypes from each tissue	HIVEP3 C10orf55 IGHM BTK	8.97e-06	168	35	4	494d5a11154ff22fedb25f4036d730cef376da60
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LAMA5 LRFN1 ITGAM SOX13	9.62e-06	171	35	4	943fbca8a6ac04052a2a85aca7b21a3461cd96f7
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-5\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPRC1 MADCAM1 IGHM BTK	9.62e-06	171	35	4	23b3120706bb9c20b9214fe3760c6d7a84f1e749
Disease	Agammaglobulinemia	IGHM BTK	8.44e-05	12	34	2	C0001768
Disease	Hypogammaglobulinemia	IGHM BTK	1.73e-04	17	34	2	C0086438
Disease	clinical treatment	PLG MYCBP2	1.03e-03	41	34	2	EFO_0007056
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP3 SOX13	1.98e-03	57	34	2	DOID:10652 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RVKCPPTYPDVVPEI	EIF2AK4	76	Q9P2K8
ITCVETVVPEKNPPP	BTK	61	Q06187
KPCVPVPVVSLEKIP	ATXN7L1	191	Q9ULK2
CPTPLDPKVLVEEAP	ABCA7	786	Q8IZY2
EAIRAVLCPPPVKKP	RAC3	171	P60763
RIPPEALVVPEVVAP	CAPN15	176	O75808
LQVKPLQVEPPEPVV	MADCAM1	21	Q13477
APVEVCVVPLPLMAP	LRFN1	381	Q9P244
VICISPGPKDVPVIP	PLXNA2	611	O75051
KEPIFEPVVLKDPCP	AUTS2	286	Q8WXX7
GCLLAEVIPVPIEVP	DIP2B	421	Q9P265
PKPPQPIILRDCQVI	LAMA5	1226	O15230
EVTLPCEVKSLPPPI	HMCN1	1096	Q96RW7
VPKLLSALCPEEPPV	EIF2B3	326	Q9NR50
ICIPIVPPKDVPVDL	BBS2	441	Q9BXC9
VPLPVIAELPPKVSV	IGHM	101	P01871
DIPCLVIPPAPAKKT	PPRC1	791	Q5VV67
TACKPVIRVPSVPPV	KRT36	411	O76013
PQVKVEPLEEAIPLP	POLR1G	311	O15446
EPPIKLPKIIEVGLC	MYCBP2	191	O75592
PPPCQKVPVELPVEV	IVL	41	P07476
KVEPFEVPNPLPLIV	ITGAM	1096	P11215
PPKDLLPVAVEILPV	SRCAP	2581	Q6ZRS2
VVAPPPVVLLPDVET	PLG	461	P00747
TCVKVLTIEPPPADP	ABTB1	221	Q969K4
LFLPCQPVPTPVVLK	C10orf55	111	Q5SWW7
AIPCPAATPVPIVEK	XIRP2	3021	A4UGR9
QLALPIQPIPCKPVE	SOX13	246	Q9UN79
HIVPCEPVPEEKPKE	SPART	401	Q8N0X7
IIPPEDLPGVPKVFV	HIVEP3	151	Q5T1R4
QFAVPVPKPLCLLVP	TOPAZ1	1021	Q8N9V7
EVVLPLDPAVPAPLC	ZCCHC4	26	Q9H5U6
VVPPVSLQDPCKELP	ZNF462	206	Q96JM2
CLTKIPDVPNLPEIP	PLEKHG2	631	Q9H7P9
KPQVIVLPIPVPIFV	ZMYM3	861	Q14202