Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainCalx_beta

FRAS1 FREM3 FREM1

2.94e-0591343IPR003644
DomainCalx-beta

FRAS1 FREM3 FREM1

2.94e-0591343PF03160
DomainV-ATPase_su_B/beta

ATP6V1B1 ATP6V1B2

5.11e-0521342IPR022879
DomainATPase_V1-cplx_bsu

ATP6V1B1 ATP6V1B2

5.11e-0521342IPR005723
DomainGrowth_fac_rcpt_

ATRN FRAS1 TNC LAMC2 TEK LRP2 LRP4

1.34e-041561347IPR009030
DomainLDLR_class-A_CS

TMPRSS15 SSPOP LRP2 LRP4

1.89e-04401344IPR023415
DomainEGF

ATRN FRAS1 TNC HYAL1 LAMC2 TEK LRP2 LRP4

2.98e-042351348SM00181
DomainLdl_recept_a

TMPRSS15 SSPOP LRP2 LRP4

3.00e-04451344PF00057
DomainEPS8_PTB

EPS8L2 EPS8L1

3.04e-0441342IPR033928
Domain-

TMPRSS15 SSPOP LRP2 LRP4

3.27e-044613444.10.400.10
DomainLDLRA_1

TMPRSS15 SSPOP LRP2 LRP4

3.86e-04481344PS01209
DomainLDrepeatLR_classA_rpt

TMPRSS15 SSPOP LRP2 LRP4

4.18e-04491344IPR002172
DomainLDLa

TMPRSS15 SSPOP LRP2 LRP4

4.18e-04491344SM00192
DomainLDLRA_2

TMPRSS15 SSPOP LRP2 LRP4

4.18e-04491344PS50068
DomainEGF-like_dom

ATRN FRAS1 TNC HYAL1 LAMC2 TEK LRP2 LRP4

4.39e-042491348IPR000742
DomainATP_synth_asu_C

ATP6V1B1 ATP6V1B2

5.04e-0451342IPR000793
DomainATP-synt_ab_N

ATP6V1B1 ATP6V1B2

5.04e-0451342PF02874
DomainATPase_F1/V1/A1_a/bsu_N

ATP6V1B1 ATP6V1B2

5.04e-0451342IPR004100
DomainATPase_a/bsu_AS

ATP6V1B1 ATP6V1B2

5.04e-0451342IPR020003
DomainATP-synt_ab_C

ATP6V1B1 ATP6V1B2

5.04e-0451342PF00306
DomainATP-synt_ab

ATP6V1B1 ATP6V1B2

5.04e-0451342PF00006
DomainATPASE_ALPHA_BETA

ATP6V1B1 ATP6V1B2

5.04e-0451342PS00152
DomainEGF_1

ATRN TNC HYAL1 LAMC2 TEK SSPOP LRP2 LRP4

5.13e-042551348PS00022
DomainACTININ_2

SPTB SPTBN5 PLEC

5.76e-04231343PS00020
DomainACTININ_1

SPTB SPTBN5 PLEC

5.76e-04231343PS00019
DomainActinin_actin-bd_CS

SPTB SPTBN5 PLEC

5.76e-04231343IPR001589
DomainEGF_2

ATRN TNC HYAL1 LAMC2 TEK SSPOP LRP2 LRP4

6.61e-042651348PS01186
DomainATPase_F1/V1/A1_a/bsu_nucl-bd

ATP6V1B1 ATP6V1B2

7.52e-0461342IPR000194
DomainEGF_extracell

ATRN TNC TEK LRP2

9.05e-04601344IPR013111
DomainEGF_2

ATRN TNC TEK LRP2

9.05e-04601344PF07974
DomainTSP_1

ADAMTS2 SSPOP UNC5A ADAMTS7

1.09e-03631344PF00090
DomainSpectrin_repeat

SPTB SPTBN5 PLEC

1.15e-03291343IPR002017
DomainTSP1

ADAMTS2 SSPOP UNC5A ADAMTS7

1.22e-03651344SM00209
DomainTSP1_rpt

ADAMTS2 SSPOP UNC5A ADAMTS7

1.22e-03651344IPR000884
DomainTSP1

ADAMTS2 SSPOP UNC5A ADAMTS7

1.22e-03651344PS50092
DomainPTB

EPS8L2 EPS8L1

1.39e-0381342IPR013625
DomainCalx_beta

FRAS1 FREM3

1.39e-0381342SM00237
DomainPTB

EPS8L2 EPS8L1

1.39e-0381342PF08416
DomainPlexin_repeat

ATRN SEMA4B PLXDC2

1.54e-03321343IPR002165
DomainSPEC

SPTB SPTBN5 PLEC

1.54e-03321343SM00150
DomainPSI

ATRN SEMA4B PLXDC2

1.54e-03321343PF01437
DomainSpectrin/alpha-actinin

SPTB SPTBN5 PLEC

1.54e-03321343IPR018159
DomainEGF_3

ATRN TNC HYAL1 TEK SSPOP LRP2 LRP4

1.55e-032351347PS50026
DomainAnoctamin

ANO9 ANO8

2.21e-03101342PF04547
DomainAnoctamin

ANO9 ANO8

2.21e-03101342IPR007632
DomainTNF_CS

TNFSF4 LTB

2.69e-03111342IPR021184
DomainEGF-like_CS

ATRN TNC HYAL1 LAMC2 TEK LRP2 LRP4

2.80e-032611347IPR013032
DomainTHDP-binding

OGDHL HACL1

3.78e-03131342IPR029061
Domain-

OGDHL HACL1

3.78e-031313423.40.50.970
DomainPSI

ATRN SEMA4B PLXDC2

3.86e-03441343IPR016201
DomainPSI

ATRN SEMA4B PLXDC2

4.38e-03461343SM00423
DomainTIL_dom

SSPOP LRP2

4.39e-03141342IPR002919
DomainLdl_recept_b

LRP2 LRP4

4.39e-03141342PF00058
DomainLDLRB

LRP2 LRP4

4.39e-03141342PS51120
DomainLY

LRP2 LRP4

5.05e-03151342SM00135
DomainLDLR_classB_rpt

LRP2 LRP4

5.05e-03151342IPR000033
DomainCarb_anhydrase

PTPRG CA6

6.48e-03171342PF00194
DomainCarb_anhydrase

PTPRG CA6

6.48e-03171342SM01057
DomainTNF_1

TNFSF4 LTB

6.48e-03171342PS00251
Domain-

PTPRG CA6

6.48e-031713423.10.200.10
DomainALPHA_CA_2

PTPRG CA6

6.48e-03171342PS51144
DomainCarbonic_anhydrase_a

PTPRG CA6

6.48e-03171342IPR001148
DomainBH3

BOK BBC3

6.48e-03171342PS01259
Pubmed

Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.

FRAS1 FREM3 FREM1

2.44e-074138318563433
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA4B FRAS1 MUS81 AMBRA1 ITGA3 DYSF KIAA2013 ANO8 TPCN1 RADIL ADAMTS7 NAPRT CPSF1 LRP4 OGDHL PLEC GPAT4 DYNC1H1

4.22e-0711051381835748872
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ATRN CDS1 IL17REL RTEL1 WWP2 SPTB G2E3 STEAP2 SSPOP ANO8 ZNF440 PARP10 PTPRG PLXDC2 RRP36 SUPT6H NAT10 SLX4IP CYB5D1 RPS6KL1 THRAP3

4.52e-0714891382128611215
Pubmed

Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.

FRAS1 FREM3 FREM1

6.08e-075138317251066
Pubmed

Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.

FRAS1 FREM3 FREM1

6.08e-075138317596926
Pubmed

A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.

FRAS1 LAMC2 FREM3 FREM1

6.95e-0718138414730302
Pubmed

Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.

FRAS1 FREM3 FREM1

1.21e-066138317462874
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

XRN2 EPS8L2 PSMD3 NUF2 METTL13 G3BP2 NAT10 CPSF1 PLEC MVP THRAP3 DYNC1H1

3.88e-065821381220467437
Pubmed

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.

FRAS1 FREM3 FREM1

7.19e-0610138315345741
Pubmed

The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.

LAMC2 ITGA3 PLEC

9.85e-0611138310811835
Pubmed

SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.

RTEL1 MUS81 LRP4 SLX4IP

1.00e-0534138431495888
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

ATRN ATP6V1B1 ATP6V1B2 EPS8L2 PSMD3 EPS8L1 ITGA3 DYSF SCRN2 TRMT10A NAPRT LRP2 CTSG MVP DYNC1H1

1.34e-0510161381519056867
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

ATP6V1B2 NIBAN1 GAPVD1 XRN2 PSMD3 SCAMP3 CRKL PRPF4 RRP36 SUPT6H NAT10 CPSF1 PLEC THRAP3 DYNC1H1

1.46e-0510241381524711643
Pubmed

Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.

ATP6V1B1 ATP6V1B2

1.56e-052138217392376
Pubmed

Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular acidosis.

ATP6V1B1 ATP6V1B2

1.56e-052138229310826
Pubmed

The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells.

MUS81 STING1

1.56e-052138227178469
Pubmed

Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.

ATP6V1B1 ATP6V1B2

1.56e-052138217898041
Pubmed

Presence of serum autoantibodies to vacuolar H+ -ATPase in patients with renal tubular acidosis.

ATP6V1B1 ATP6V1B2

1.56e-052138230821427
Pubmed

Overlapping and divergent localization of Frem1 and Fras1 and its functional implications during mouse embryonic development.

FRAS1 FREM1

1.56e-052138217240369
Pubmed

The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.

ATP6V1B1 TRPV5

1.56e-052138219470676
Pubmed

Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms.

ATP6V1B1 ATP6V1B2

1.56e-05213827945239
Pubmed

Defining the membrane proteome of NK cells.

NIBAN1 XRN2 WWP2 PSMD3 NUF2 LMBRD2 KIAA2013 SLC4A2 MGAT2 LMF2 DCP1B NAT10 EIF3K MVP GPAT4 DYNC1H1

1.70e-0511681381619946888
Pubmed

SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations.

RTEL1 MUS81 SLX4IP

2.69e-0515138332398829
Pubmed

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.

TNC NUF2 PPM1B PCGF6 CPSF1 PLEC MVP

3.14e-05222138735941108
Pubmed

Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.

TNC FREM3 FREM1

3.30e-0516138315878328
Pubmed

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.

PSMD3 ITGA3 G3BP2 MVP DYNC1H1

3.59e-0593138538245532
Pubmed

Murine ameloblasts are immunonegative for Tcirg1, the v-H-ATPase subunit essential for the osteoclast plasma proton pump.

ATP6V1B2 SLC4A2

4.68e-053138222245629
Pubmed

Laminin-332 and α3β1 integrin-supported migration of bronchial epithelial cells is modulated by fibronectin.

LAMC2 ITGA3

4.68e-053138223590307
Pubmed

CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility.

RTEL1 CCDC26

4.68e-053138226014354
Pubmed

Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit.

ATP6V1B1 ATP6V1B2

4.68e-053138217971301
Pubmed

Expression of Fraser syndrome genes in normal and polycystic murine kidneys.

FRAS1 FREM3

4.68e-053138221993971
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTB ITGA3 SPTBN5

4.77e-0518138312119179
Pubmed

Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis.

ATP6V1B1 ATP6V1B2 LRP2

5.65e-0519138316177003
Pubmed

Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.

ATP6V1B1 ATP6V1B2 LRP2

5.65e-0519138334667084
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

FRAS1 TNC LAMC2 F13A1 FREM1 PLXDC2

5.70e-05167138622159717
Pubmed

H+-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.

ATP6V1B1 ATP6V1B2

9.33e-054138229993276
Pubmed

The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.

FRAS1 FREM1

9.33e-054138229618029
Pubmed

Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.

FRAS1 FREM1

9.33e-054138223221805
Pubmed

Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5.

LAMC2 ITGA3

9.33e-054138210801807
Pubmed

Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.

FRAS1 FREM1

9.33e-054138236495293
Pubmed

Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin.

LAMC2 ITGA3

9.33e-054138219118220
Pubmed

In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.

EPS8L2 EPS8L1

9.33e-054138212620401
Pubmed

Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.

RICTOR GPAT4

9.33e-054138224939733
Pubmed

Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.

FRAS1 FREM3

9.33e-054138224101214
Pubmed

Expression of laminin-5 and integrins in actinic cheilitis and superficially invasive squamous cell carcinomas of the lip.

LAMC2 ITGA3

9.33e-054138222917688
Pubmed

Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus.

TEK LTB

9.33e-054138219735075
Pubmed

V-ATPase expression in the mouse olfactory epithelium.

ATP6V1B1 ATP6V1B2

9.33e-054138218667600
Pubmed

Joint associations between genetic variants and reproductive factors in glioma risk among women.

RTEL1 CCDC26

9.33e-054138221920947
Pubmed

CFTR and TMEM16A are separate but functionally related Cl- channels.

ANO9 ANO8

9.33e-054138222178883
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

ATRN ATP6V1B1 ATP6V1B2 NIBAN1 EPS8L2 HYAL1 WWP2 EPS8L1 DYSF PTPRG NAPRT LRP2 CTSG DYNC1H1

9.59e-0510701381423533145
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

NET1 TNC DYSF MAGI2 SCRN2 ZNF106 OGDHL PLEC

1.07e-04363138814691545
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

ATRN SEMA4B TRIL EFNA3 PLXDC2

1.07e-04117138517145500
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

FRAS1 TNC FREM3 SSPOP

1.25e-0464138422261194
Pubmed

Recombinant human laminin-5 domains. Effects of heterotrimerization, proteolytic processing, and N-glycosylation on alpha3beta1 integrin binding.

LAMC2 ITGA3

1.55e-045138214612440
Pubmed

Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy.

ATP6V1B1 ATP6V1B2

1.55e-045138227384406
Pubmed

Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.

FRAS1 CRKL

1.55e-045138223469164
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP2 LRP4

1.55e-045138219047013
Pubmed

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.

STING1 BBC3

1.55e-045138229581256
Pubmed

Altered ion-responsive gene expression in Mmp20 null mice.

SLC4A2 CA6

1.55e-045138220929715
Pubmed

Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes.

PARP10 PLEC

1.55e-045138225318670
Pubmed

Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.

LCK TEK

1.55e-04513827545683
Pubmed

Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.

FRAS1 FREM1

1.55e-045138223536828
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CCDC170 ATRN GAPVD1 YBEY FRS2 SSPOP QRICH2 SNAI3 LRP2 CPSF1 DYNC1H1

1.79e-047361381129676528
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

RTEL1 SSPOP PPM1B LRP2

1.88e-0471138433541421
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

USP45 NET1 HMX3 AMBRA1 PSMD3 CRKL ATXN7L3 DCP1B PRPF4 SUPT6H G3BP2 EIF3K PLEC

1.92e-0410051381319615732
Pubmed

Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.

FRAS1 LAMC2 FREM1

2.07e-0429138322613833
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS2 SSPOP UNC5A ADAMTS7

2.32e-0475138420637190
Pubmed

Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.

FRAS1 FREM1

2.32e-046138224700879
Pubmed

RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.

RTEL1 MUS81

2.32e-046138222579284
Pubmed

Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G.

LCK CRKL

2.32e-04613828626543
Pubmed

Interaction between 5 genetic variants and allergy in glioma risk.

RTEL1 CCDC26

2.32e-046138220462933
Pubmed

Craniofacial consequences of connective tissue disorders in mice.

FRAS1 FREM1

2.32e-04613826391574
Pubmed

Junctional Epidermolysis Bullosa

LAMC2 PLEC

2.32e-046138220301304
Pubmed

Eps8 controls actin-based motility by capping the barbed ends of actin filaments.

EPS8L2 EPS8L1

2.32e-046138215558031
Pubmed

Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.

LCK TEK

2.32e-04613828661721
Pubmed

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

WWP2 MAGI2

2.32e-04613829647693
Pubmed

Genetic risk profiles identify different molecular etiologies for glioma.

RTEL1 CCDC26

2.32e-046138220847058
Pubmed

Analysis of the Tropism of SARS-CoV-2 Based on the Host Interactome of the Spike Protein.

LAMC2 PLEC THRAP3

2.53e-0431138337939376
Pubmed

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.

ATP6V1B2 NIBAN1 PSMD3 RICTOR PLEC MVP DYNC1H1

2.60e-04312138737120454
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

RTEL1 MUS81 ZNF106 PRPF4 SUPT6H SLX4IP

2.70e-04222138637071664
Pubmed

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

ATP6V1B1 ATP6V1B2 NIBAN1 EPS8L2 PLEC MVP DYNC1H1 CA6

2.73e-04417138819199708
Pubmed

GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

XRN2 PPM1B PRPF4 G3BP2 NAT10 THRAP3

2.76e-04223138633731348
Pubmed

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

XRN2 PSMD3 STING1 PPM1B PCGF6 G3BP2 NAT10

2.81e-04316138731665637
Pubmed

SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.

WWP2 SCAMP3

3.24e-047138219158374
Pubmed

Lrp4 is a receptor for Agrin and forms a complex with MuSK.

CRKL LRP4

3.24e-047138218848351
Pubmed

Optic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunit.

ATP6V1B1 ATP6V1B2

3.24e-047138220711468
Pubmed

Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.

LCK CRKL

3.24e-04713829020138
Pubmed

Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress.

RICTOR DCP1B

3.24e-047138221964062
Pubmed

Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK targets in embryonic kidney.

ATP6V1B1 ATP6V1B2

3.24e-047138235550069
Pubmed

The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.

LAMC2 PLEC

3.24e-047138210637308
Pubmed

Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.

ATP6V1B1 LRP2 TRPV5

3.34e-0434138335341793
Pubmed

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.

PPM1B PLEC MVP DYNC1H1

3.58e-0484138425670202
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

ANKRD31 FRAS1 RTEL1 FREM1 PLEC

3.63e-04152138534299191
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

XRN2 AMBRA1 PSMD3 PPM1B G3BP2 NAT10 CPSF1 PLEC THRAP3

3.71e-04551138934728620
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

GAPVD1 XRN2 AMBRA1 RICTOR SMG8 SUPT6H G3BP2 NAT10

3.90e-04440138834244565
Pubmed

Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.

CDS1 SCAMP3 LMBRD2

3.97e-0436138338070861
Pubmed

Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.

WWP2 CRKL G3BP2

3.97e-0436138315717329
Pubmed

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

CCDC170 PSMD3 PPM1B G3BP2 EIF3K PLEC MVP THRAP3 DYNC1H1

4.06e-04558138927591049
Pubmed

The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.

ANO9 ANO8

4.31e-048138221984732
Pubmed

Expression and function of epithelial anoctamins.

ANO9 ANO8

4.31e-048138220056604
InteractionRASAL1 interactions

GAPVD1 BCKDK STING1 NAPRT

8.59e-06201354int:RASAL1
InteractionIGFL3 interactions

ATRN FRAS1 ADAMTS2 ADAMTS7 LRP2 LRP4

1.11e-05751356int:IGFL3
GeneFamilyEF-hand domain containing|Spectrins

SPTB SPTBN5

5.41e-0479321113
GeneFamilyAnoctamins

ANO9 ANO8

1.15e-0310932865
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 TMPRSS15 SSPOP FREM1 ZFHX4 LRP2 HYDIN

1.76e-0618413872cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 TMPRSS15 SSPOP FREM1 ZFHX4 LRP2 HYDIN

1.76e-061841387ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 TMPRSS15 SSPOP FREM1 ZFHX4 LRP2 HYDIN

1.76e-0618413872b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellFetal_29-31_weeks-Mesenchymal|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTS2 TNC STEAP2 FREM1 MAGI2 PTPRG PLXDC2

2.86e-06198138721cf4d81386761d09d0f6829c01c198e5524176d
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|367C / Donor, Lineage, Cell class and subclass (all cells)

NIBAN1 IKZF2 LCK DCP1B LTB CA6

9.64e-061571386f1c6c313836352271033d23efd31b0f0a8a09e02
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 FREM1 ZFHX4 PTPRG LRP2 HYDIN

1.07e-051601386c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 FREM1 ZFHX4 PTPRG LRP2 HYDIN

1.07e-05160138625c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTEL1 LCK TPCN1 NAT10 LTB BBC3

1.52e-0517013863ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

SPTB DYSF SSPOP TRIL RADIL ADAMTS7

1.62e-051721386c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ATRN IKZF2 ZNF473 ITGA3 F13A1 RRP36

1.67e-051731386efb8072475000888efe088d00e870c56ffad4172
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ATRN IKZF2 ZNF473 ITGA3 F13A1 RRP36

1.73e-05174138658300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 FREM1 ZFHX4 LRP2 LTB HYDIN

1.79e-051751386887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellmetastatic_Brain-Endothelial_cells-Lymphatic_ECs|Endothelial_cells / Location, Cell class and cell subclass

IKZF2 AMBRA1 QRICH2 AP1AR RADIL ZFHX4

1.84e-05176138642541dfe20eb29625d47c0bb79bf3c21a2460340
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

NIBAN1 FRAS1 EPS8L2 CYP27C1 FAM111B MAGI2

1.97e-05178138635a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellmetastatic_Brain-Endothelial_cells-Lymphatic_ECs|metastatic_Brain / Location, Cell class and cell subclass

IKZF2 DYSF QRICH2 APLF RADIL ZFHX4

2.03e-05179138656fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

TEK FREM1 ZNF106 ZFHX4 PTPRG PLXDC2

2.37e-05184138667164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellpdx|World / Sample and Cell Type and Tumor Cluster (all cells)

CCDC170 FRAS1 FRS2 PTPRG LRP4 CA6

2.52e-051861386de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCellpdx-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

CCDC170 FRAS1 FRS2 PTPRG LRP4 CA6

2.52e-0518613860b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FRAS1 EPS8L2 NET1 LAMC2 ITGA3 FREM3

2.59e-0518713864ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 HOXB-AS3 LAMC2 ITGA3 PTPRG HYDIN

2.75e-051891386aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRAS1 HOXB-AS3 LAMC2 ITGA3 PTPRG HYDIN

2.75e-0518913868977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NIBAN1 GAPVD1 NET1 ADAMTS2 TNC G3BP2

2.84e-051901386d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellILEUM-inflamed-(1)_Tregs|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NIBAN1 IKZF2 STING1 LCK G3BP2 LTB

3.01e-0519213861fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

FRAS1 ADAMTS2 TNC FREM1 MAGI2 PTPRG

3.10e-051931386acad568621ed677031797b8c2e34dafea798d681
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTS2 TNC FREM1 MAGI2 PTPRG PLXDC2

3.19e-051941386011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FREM1 MAGI2 TRIL ZFHX4 PTPRG PLXDC2

3.28e-0519513860e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellMesenchymal|World / Lineage, Cell type, age group and donor

ADAMTS2 TNC STEAP2 FREM1 MAGI2 PTPRG

3.67e-0519913864bac110c2b3609f6ee5d0e3275da0824a6240270
DiseaseFraser syndrome (implicated_via_orthology)

FRAS1 FREM1

1.18e-0441322DOID:0090001 (implicated_via_orthology)
Diseasefollicular lymphoma (implicated_via_orthology)

ATP6V1B1 ATP6V1B2

1.97e-0451322DOID:0050873 (implicated_via_orthology)
Diseasemyeloperoxidase measurement

ATP6V1B2 SMG8 CCDC26

2.11e-04261323EFO_0005243
DiseaseJunctional Epidermolysis Bullosa

LAMC2 ITGA3

2.94e-0461322C0079301
Diseasejunctional epidermolysis bullosa (is_implicated_in)

LAMC2 ITGA3

4.11e-0471322DOID:3209 (is_implicated_in)
DiseaseUnilateral agenesis of kidney

FRAS1 FREM1

5.46e-0481322C0266294
Diseaseage at onset, glioblastoma multiforme

RTEL1 CCDC26

5.46e-0481322EFO_0000519, EFO_0004847
Diseaserenal tubular acidosis (implicated_via_orthology)

ATP6V1B1 ATP6V1B2

5.46e-0481322DOID:14219 (implicated_via_orthology)
Disease

F13A1 TNFSF4

1.50e-03131322608446
DiseaseMyocardial infarction, susceptibility to

F13A1 TNFSF4

1.50e-03131322cv:C1832662
Diseasecentral nervous system cancer, glioblastoma multiforme

RTEL1 CCDC26

1.74e-03141322EFO_0000326, EFO_0000519
DiseaseAutosomal recessive limb-girdle muscular dystrophy

DYSF PLEC

1.74e-03141322cv:C2931907
DiseaseProteinuria

ADAMTS7 LRP2

2.01e-03151322HP_0000093
Diseasedense area measurement, mammographic density measurement

CCDC170 MAGI2

3.23e-03191322EFO_0005941, EFO_0006503
Diseasegastric ulcer (biomarker_via_orthology)

TEK F13A1

3.94e-03211322DOID:10808 (biomarker_via_orthology)
Diseaseglioma

RTEL1 CCDC26

4.33e-03221322EFO_0005543
Diseasehip bone mineral density, fat body mass

CCDC170 HOXB-AS3

4.33e-03221322EFO_0005409, EFO_0007702

Protein segments in the cluster

PeptideGeneStartEntry
RHQSPIDILDQYARV

PTPRG

81

P23470
NIQHINRIYRDRNVP

YBEY

46

P58557
QYERRRQEEQQRHRP

BBC3

151

Q9BXH1
AQPGHRSYNLQERRR

SLC4A2

226

P04920
LARHPEVQQTVYREI

CYP27C1

366

Q4G0S4
IEYRHNTLPVRNVLD

APLF

436

Q8IW19
VLRQERVSLYPFQIH

CDS1

341

Q92903
ENVNIYRARHREPRP

EEF1AKMT3

211

Q96AZ1
LEQERQRIVQQYHPS

AP1AR

126

Q63HQ0
SHYRQRALLQSQPVR

AMBRA1

221

Q9C0C7
YVLVAQRHTQRDPRQ

ANO9

36

A1A5B4
QHLRTRDIINVSNRY

CCNQ

86

Q8N1B3
ARYLQQELPVRIAHR

BCKDK

91

O14874
RPSVYRNVARQLHIS

BOK

81

Q9UMX3
QRRYFTPAEVAQHNR

CYB5D1

16

Q6P9G0
NDYRRTQPLNHRVVE

CA6

261

P23280
CPQHTDEQRRTVRIY

ATXN7L3

226

Q14CW9
RRSQSARVPIQGHYR

ATP10B

506

O94823
QEAEQGRVHVVYRRP

ADAMTS2

201

O95450
HVVYKRQAPERLAQR

ADAMTS7

181

Q9UKP4
QNVREVLQPHLYRRL

ANO8

481

Q9HCE9
IRPYTVFELEQVRQH

QRICH2

1456

Q9H0J4
RTVLQNYLPRHRLDA

HACL1

406

Q9UJ83
YVLNRDRHTVGQRTP

RADIL

266

Q96JH8
VLTRPVTRNERHSYQ

NET1

411

Q7Z628
VTRNERHSYQVYRQP

NET1

416

Q7Z628
SRRINRLVTYQQHIP

ANKRD31

756

Q8N7Z5
YLVSPQAEKHRRARN

MSANTD1

31

Q6ZTZ1
LPLCRNYVRRVHVDQ

TCTE1

181

Q5JU00
LLPYHQNTLQSRRTR

KLHL31

296

Q9H511
QAPYVLRNEVLHISR

FRAS1

1216

Q86XX4
EHVVRVNARVRISYP

MAGEA8

291

P43361
YVDHINRRTQFENPV

MAGI2

366

Q86UL8
SVERYVAVVHPLQAR

NMUR1

156

Q9HB89
GTQRYPHQRRRFQAA

HOXB-AS3

6

C0HLZ6
SSQLVHRRVQYPLVD

IL17REL

251

Q6ZVW7
RELVLVVQVHNRPEY

MGAT2

116

Q10469
QVLRVVRQVTHPNYN

KLK14

106

Q9P0G3
SHAAAQRIVRVPILY

HMX3

296

A6NHT5
QRIVRVPILYHENSA

HMX3

301

A6NHT5
PLNRSVNNVVVRYGH

ATRN

381

O75882
EIVINPHYNRRRKDN

TMPRSS15

861

P98073
TANHRALQIPEVYLR

GAPVD1

1356

Q14C86
RVVRVEHRATRQPYA

PSKH1

111

P11801
SRQSRPYLLVHVDQE

CPSF1

856

Q10570
VALHRQTERQQRYLL

ITGA3

56

P26006
YHERINRVTNRNITL

OGDHL

341

Q9ULD0
FPRYNVAEIVIHIRN

NUF2

6

Q9BZD4
QVTHQRAVDTIRRAY

PDZD7

921

Q9H5P4
YVQSRHLRIEPTADQ

FREM1

1106

Q5H8C1
RIYHQNQRADKRRAQ

KCND2

411

Q9NZV8
QIQEIQRTPQRYSSR

L1RE1

196

Q9UN81
RHVYGELDVQIQRRP

F13A1

716

P00488
QHQRLVRLYAVVTQE

LCK

296

P06239
VPNLRGLQVYHRRNA

LRP2

2001

P98164
LLQHTPSARRNYRIA

C6orf223

201

Q8N319
SRVSHYIINSLPNRR

CRKL

56

P46109
SQVYHPNRIERPISR

IKZF2

356

Q9UKS7
DNYVRRSNQRLQRPH

RICTOR

861

Q6R327
RSNQRLQRPHVYLPI

RICTOR

866

Q6R327
ISNIRAQPQRHFRVE

EPS8L2

601

Q9H6S3
RVVSYRVPHNAAVQV

MVP

456

Q14764
IRVNVFREHRQTIQY

NAT10

356

Q9H0A0
YNSNIPVIHVFRRRV

OSGIN2

321

Q9Y236
RQRQPHVCYEQAQRL

CCDC105

466

Q8IYK2
VHARQRTQNVPINKY

CCDC26

46

Q8TAB7
LQRHDPYINRIVDVA

DCP1B

21

Q8IZD4
DHRPVQIITSNNYRE

G2E3

126

Q7L622
RVTVVRPVLHNQYGN

HYDIN

3476

Q4G0P3
NQHLRREGYTVQVNV

EFNA3

41

P52797
TAIITYHDRENRPRN

GPAT4

226

Q86UL3
RPSLEHRQLNYIQVD

FRS2

426

Q8WU20
NRRIIRYPDSHQLFV

G3BP2

321

Q9UN86
LRYVNSTRAPQRAHE

FBXO28

181

Q9NVF7
NEPSVALYRLQEHVR

BORCS8

26

Q96FH0
QAHQEERPIRQILYL

EIF3K

91

Q9UBQ5
HIRGAIREYQTQLIQ

DYNC1H1

596

Q14204
QYQNRVRDTHRLITQ

LAMC2

711

Q13753
QQHITARRAIRHPQY

CTSG

86

P08311
ARRAIRHPQYNQRTI

CTSG

91

P08311
IYRQRSRALVQAQHP

HYAL1

146

Q12794
SEVPVTREQLNHYRN

CCDC170

26

Q8IYT3
RRLITVALHRGQQYE

METTL13

331

Q8N6R0
HERRRRQQSAPQVAV

EPS8L1

446

Q8TE68
KYRQINSQVRRRPHL

FAM111B

356

Q6SJ93
VIQHRPSRQYATLDV

SCAMP3

26

O14828
YQRVPAHQVLFSRRG

DYSF

806

O75923
VHQTQPLYNIRLDRQ

PCGF6

176

Q9BYE7
VRVERVSHPLLQQQY

PARP10

851

Q53GL7
PRRYQVMRQHSRQQL

SMG8

376

Q8ND04
LRDIQVRHINYVQSI

FREM3

1141

P0C091
IVRFTRQLQRVHPNV

RPUSD4

76

Q96CM3
VNQAIGRVIRHRQDY

RTEL1

691

Q9NZ71
QIYVDRQLHNRQIYP

ATP6V1B2

376

P21281
ITEGQIYVDRQLHNR

ATP6V1B1

366

P15313
ILPELQARIRTYNQH

STING1

171

Q86WV6
CRVLVQQRYRHQGPA

SSPOP

4381

A2VEC9
VIRLVQSQVARYPFH

LMF2

536

Q9BU23
KQVIYSVQRHRRTQV

LMBRD2

311

Q68DH5
LRQRRCVYTIPAHQN

PRPF4

436

O43172
PRFQTQVDRRHTLYR

SCRN2

346

Q96FV2
QPQARYQRVAVHRVP

SEMA4B

441

Q9NPR2
QQIPNVRRRTIYEYH

PLXDC2

291

Q6UX71
FVRDVIHPYARNQQS

STEAP2

231

Q8NFT2
VPRHLRQTYIRQVGE

MYBPH

176

Q13203
NVIEAVYSRLNPHRE

PPM1B

361

O75688
GQTRVTLRNEHLQYI

SURF1

261

Q15526
APRRYPHIQAQRSRI

SPTBN5

3176

Q9NRC6
SRVQEYLEVRKQHRP

SLX4IP

51

Q5VYV7
SSHRVPNYRRLETQR

SNAI3

11

Q3KNW1
DIYVGRVLHQVTPNR

B3GALT9

206

A8MXE2
HRRPQGESYDQAIRN

SUPT6H

1176

Q7KZ85
PYARIQQSRRQCHAE

SMIM2

61

Q9BVW6
EPVLQHSQYLRLRQR

TLR8

981

Q9NR97
NIEYEHQNPRRNFRS

ZNF440

51

Q8IYI8
LQRQTLHTRERPYEC

ZNF586

166

Q9NXT0
QQKRQPLSVSDRHVY

ZFHX4

1336

Q86UP3
VHNRQPRINSYVEVA

WWP2

31

O00308
ERNHPRVYQNRDFRG

THRAP3

61

Q9Y2W1
QVSHRYPRIQSIKVQ

TNFSF4

51

P23510
RYSGNVTIENIHQPR

USP45

411

Q70EL2
HQNRQVYRAIAEQLR

ZSCAN20

351

P17040
IYSTREPQLAFHQRI

PSMD3

466

O43242
RFRFPHIDLVVQRTQ

NIBAN1

426

Q9BZQ8
RRLDLQYNQIRSLHP

TRIL

86

Q7L0X0
YIRRQRAQPNHDPNT

XRN2

211

Q9H0D6
NQIVFTHRINIPRRA

TNC

96

P24821
PEHRRLRSPAQYQVV

NAPRT

506

Q6XQN6
RARSQAHVYLEQIRN

RPS6KL1

21

Q9Y6S9
KQERRAQAQQGHRPY

RRP36

196

Q96EU6
HRLQALRELYQQVVA

SPTB

821

P11277
HPREQYVVRARVNTK

TEK

606

Q02763
VDPVRNQRLYVHEAV

PLEC

3536

Q15149
PNVYITREHSLVVRQ

UNC5A

196

Q6ZN44
AIQHAYRLLISQRRP

TPCN1

341

Q9ULQ1
VQIINYIKARPHQSR

ZBED5

396

Q49AG3
QRCYAENRRALHPVQ

TRMT10A

126

Q8TBZ6
RTHRIQILQGLQETY

ZNF106

1106

Q9H2Y7
HNDQNPLRVLRYVEV

TRPV5

636

Q9NQA5
YIEDEHQNPRRNLRR

ZNF878

51

C9JN71
RVFTQRNYLVQHERT

ZNF473

681

Q8WTR7
VQLRRGERVYVNISH

LTB

211

Q06643
RGRPHVYLQRIQLNN

KIAA2013

196

Q8IYS2
NRIDIRQVLPHRSEY

LRP4

446

O75096
RNLVLRTHQPARYSL

MUS81

191

Q96NY9