Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	HSPD1 ERCC6 SPAST VWA8 CHD7 RFC1 DHX9 ACSL4 MDN1 RALBP1 SMC1B SLC27A4	3.42e-05	614	95	12	GO:0140657
GeneOntologyMolecularFunction	palmitoyl-CoA ligase activity	ACSL4 SLC27A4	6.70e-05	3	95	2	GO:0090433
GeneOntologyMolecularFunction	ligase activity	CPS1 ACSL4 SARS1 BTRC SLC27A4 ADSS1	1.84e-04	174	95	6	GO:0016874
GeneOntologyMolecularFunction	ATP hydrolysis activity	HSPD1 ERCC6 SPAST VWA8 CHD7 RFC1 DHX9 MDN1 SMC1B	2.53e-04	441	95	9	GO:0016887
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	HSPD1 ERCC6 SPAST VWA8 CHD7 RFC1 DHX9 MDN1 GNAO1 RAB26 SMC1B ADSS1	3.06e-04	775	95	12	GO:0017111
GeneOntologyMolecularFunction	modification-dependent protein binding	HSPD1 ANK3 UBXN1 IKBKE SPIN1 SPIN3	4.54e-04	206	95	6	GO:0140030
GeneOntologyMolecularFunction	spectrin binding	ANK3 DCTN2 SPTAN1	5.61e-04	34	95	3	GO:0030507
GeneOntologyMolecularFunction	pyrophosphatase activity	HSPD1 ERCC6 SPAST VWA8 CHD7 RFC1 DHX9 MDN1 GNAO1 RAB26 SMC1B ADSS1	6.21e-04	839	95	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	HSPD1 ERCC6 SPAST VWA8 CHD7 RFC1 DHX9 MDN1 GNAO1 RAB26 SMC1B ADSS1	6.28e-04	840	95	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	HSPD1 ERCC6 SPAST VWA8 CHD7 RFC1 DHX9 MDN1 GNAO1 RAB26 SMC1B ADSS1	6.28e-04	840	95	12	GO:0016818
GeneOntologyMolecularFunction	cytoskeletal protein binding	ABRA DIP2B SPAST DCDC1 ANK3 DCTN2 SPTAN1 COBL RP1 SNCB PLK1 FMNL1 FKBP4 ADSS1	6.78e-04	1099	95	14	GO:0008092
GeneOntologyMolecularFunction	very long-chain fatty acid-CoA ligase activity	ACSL4 SLC27A4	9.83e-04	10	95	2	GO:0031957
GeneOntologyMolecularFunction	K48-linked polyubiquitin modification-dependent protein binding	UBXN1 IKBKE	9.83e-04	10	95	2	GO:0036435
GeneOntologyMolecularFunction	arachidonate-CoA ligase activity	ACSL4 SLC27A4	1.20e-03	11	95	2	GO:0047676
Domain	AMP-binding	DIP2B ACSL4 DIP2C SLC27A4	1.49e-05	30	94	4	PF00501
Domain	AMP-dep_Synth/Lig	DIP2B ACSL4 DIP2C SLC27A4	1.49e-05	30	94	4	IPR000873
Domain	VWFA	VWA8 ITGA2 ITGAX CFB MDN1	5.83e-05	82	94	5	PS50234
Domain	VWA	VWA8 ITGA2 ITGAX CFB MDN1	6.54e-05	84	94	5	SM00327
Domain	VWF_A	VWA8 ITGA2 ITGAX CFB MDN1	1.43e-04	99	94	5	IPR002035
Domain	VWA	VWA8 ITGA2 ITGAX CFB	1.81e-04	56	94	4	PF00092
Domain	Spin-Ssty	SPIN1 SPIN3	2.48e-04	5	94	2	PF02513
Domain	DMAP_binding	DIP2B DIP2C	2.48e-04	5	94	2	PF06464
Domain	SPIN/Ssty	SPIN1 SPIN3	2.48e-04	5	94	2	IPR003671
Domain	AMP_BINDING	ACSL4 DIP2C SLC27A4	3.69e-04	28	94	3	PS00455
Domain	DMAP1-bd	DIP2B DIP2C	3.71e-04	6	94	2	IPR010506
Domain	DMAP_binding	DIP2B DIP2C	3.71e-04	6	94	2	SM01137
Domain	-	DCDC1 RP1	5.18e-04	7	94	2	3.10.20.230
Domain	DC	DCDC1 RP1	6.88e-04	8	94	2	PS50309
Domain	Doublecortin_dom	DCDC1 RP1	6.88e-04	8	94	2	IPR003533
Domain	P-loop_NTPase	SAMD9 ERCC6 SPAST VWA8 CHD7 RFC1 DHX9 MDN1 GNAO1 RAB26 SMC1B ADSS1	1.11e-03	848	94	12	IPR027417
Domain	-	SAMD9 ERCC6 SPAST VWA8 CHD7 RFC1 DHX9 MDN1 GNAO1 RAB26 SMC1B	1.30e-03	746	94	11	3.40.50.300
Domain	ATPase_dyneun-rel_AAA	VWA8 MDN1	2.19e-03	14	94	2	IPR011704
Domain	AAA_5	VWA8 MDN1	2.19e-03	14	94	2	PF07728
Domain	Integrin_alpha_C_CS	ITGA2 ITGAX	2.87e-03	16	94	2	IPR018184
Domain	Integrin_alpha-2	ITGA2 ITGAX	3.64e-03	18	94	2	IPR013649
Domain	Integrin_alpha2	ITGA2 ITGAX	3.64e-03	18	94	2	PF08441
Domain	Integrin_alpha	ITGA2 ITGAX	3.64e-03	18	94	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA2 ITGAX	3.64e-03	18	94	2	PS00242
Domain	DSRM	NKRF DHX9	4.05e-03	19	94	2	SM00358
Domain	Int_alpha_beta-p	ITGA2 ITGAX	4.05e-03	19	94	2	IPR013519
Domain	Int_alpha	ITGA2 ITGAX	4.05e-03	19	94	2	SM00191
Domain	dsrm	NKRF DHX9	4.49e-03	20	94	2	PF00035
Domain	FG_GAP	ITGA2 ITGAX	5.42e-03	22	94	2	PS51470
Pubmed	A protein interaction landscape of breast cancer.	ANK3 VWA8 TRIP11 NKRF DHX9 ACSL4 IGF2R MDN1 SARS1 NUAK1 TSPYL5 FKBP4 SLC27A4	2.50e-08	634	97	13	34591612
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	HSPD1 SAMD9 DCTN2 SPTAN1 RFC1 NKRF DHX9 CDK11B SPIN3	2.67e-07	316	97	9	31665637
Pubmed	Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome.	TNC ITGA2 RP1	7.30e-07	7	97	3	11767049
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ERCC6 ANK3 MDN1 SARS1 IKBKE COBL MYOM2 RP1 CDK11B PLK1	1.34e-06	497	97	10	36774506
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	HSPD1 VWA8 SPTAN1 RFC1 DHX9 MDN1 SPIN1	2.83e-06	219	97	7	31353912
Pubmed	Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.	NUAK1 PLK1 BTRC	4.54e-06	12	97	3	24785407
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HSPD1 ERCC6 SPTAN1 CHD7 UBXN1 RFC1 NKRF DHX9 ACSL4 MDN1 UBN1 AKAP13 PLK1 BTRC SLC27A4	5.08e-06	1353	97	15	29467282
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DIP2B SPAST SPTAN1 CDK14 TRIP11 FSIP2 PANK2 MDN1 IKBKE COBL AKAP13 PLK1	5.10e-06	861	97	12	36931259
Pubmed	MLL4 binds TET3.	KMT2B TET3	7.70e-06	2	97	2	38579707
Pubmed	Application of champedak mannose-binding lectin in the glycoproteomic profiling of serum samples unmasks reduced expression of alpha-2 macroglobulin and complement factor B in patients with nasopharyngeal carcinoma.	A2M CFB	7.70e-06	2	97	2	20575108
Pubmed	GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.	SPTAN1 GNAO1	7.70e-06	2	97	2	33107105
Pubmed	The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.	ITGA2 RETSAT TRIP11 IGF2R FMNL1 SLC27A4	1.04e-05	176	97	6	28692057
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	TNC SPTAN1 PPP2R3B BANF1 PDIA4 IGF2R REEP6 AKR1B10 CREB3	1.19e-05	503	97	9	36217030
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2B VWA8 TASP1 BANF1 IGF2R MDN1 UBN1 NUAK1 DIP2C COBL AKAP13 PRRC2B CREB3	1.24e-05	1105	97	13	35748872
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	HSPD1 DCDC1 ZNF618 SPTAN1 SPIN1 ANKRD36	1.47e-05	187	97	6	26460568
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	A2M KMT2B DCTN2 SPTAN1 CHGA RFC1 NKRF PDIA4 WFIKKN1 TLE1 SURF2 PLK1 BTRC	1.48e-05	1124	97	13	21900206
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	HSPD1 TIGAR ANK3 VWA8 DCTN2 SPTAN1 DHX9 PDIA4 DNAJC17 IGF2R MDN1 SARS1 LRPAP1 AKAP13 FKBP4	1.56e-05	1487	97	15	33957083
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	CPS1 RFC1 DHX9 ACSL4 PANK2 AKAP13	1.61e-05	190	97	6	15161933
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	A2M SAMD9 ANK3 ZNF618 PDIA4 FKBP4 SLC27A4	1.69e-05	288	97	7	38496616
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	ERCC6 ANK3 UBXN1 RFC1 NKRF PDIA4 SPIN1 PRRC2B	1.78e-05	403	97	8	35253629
Pubmed	Defining the membrane proteome of NK cells.	HSPD1 DIP2B RETSAT ITGAX DHX9 ACSL4 IGF2R MDN1 AKAP13 PLD1 FMNL1 SLC27A4 NCKAP1L	2.21e-05	1168	97	13	19946888
Pubmed	CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.	DIP2B DIP2C	2.31e-05	3	97	2	17236128
Pubmed	Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.	A2M LRPAP1	2.31e-05	3	97	2	12394648
Pubmed	Novel function of tenascin-C, a matrix protein relevant to atherosclerosis, in platelet recruitment and activation under flow.	TNC ITGA2	2.31e-05	3	97	2	20651280
Pubmed	Sequence variants in SPAST, SPG3A and HSPD1 in hereditary spastic paraplegia.	HSPD1 SPAST	2.31e-05	3	97	2	19423133
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	A2M VWA8 SPTAN1 TASP1 CHD7 RFC1 NKRF ACSL4 SPIN1 RALBP1 AKR1B10 CDK11B PLD1 PRRC2B	2.69e-05	1371	97	14	36244648
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	HSPD1 A2M DIP2B SPTAN1 ACSL4 SARS1 FMNL1 FKBP4 NCKAP1L	2.97e-05	565	97	9	20458337
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ANK3 SPTAN1 PPP2R3B BANF1 PDIA4 ACSL4 IGF2R SMG7 PLK1 FKBP4 BTRC PRRC2B	3.60e-05	1049	97	12	27880917
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ZNF536 EGLN1 CHD7 PDIA4 IGF2R TLE1 LRPAP1 AKAP13 CDK11B SLC27A4	3.93e-05	733	97	10	34672954
Pubmed	Human transcription factor protein interaction networks.	HSPD1 ZNF536 KMT2B SPTAN1 CHD7 RFC1 BANF1 NKRF PDIA4 SMG7 UBN1 TLE1 FKBP4 PRRC2B	4.23e-05	1429	97	14	35140242
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	TIGAR RETSAT TRIP11 BANF1 SMG7 TLE1 FKBP4 PRRC2B	4.35e-05	457	97	8	32344865
Pubmed	Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability.	EGLN1 PLD1	4.60e-05	4	97	2	25361009
Pubmed	SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.	PLK1 BTRC	4.60e-05	4	97	2	16885022
Pubmed	Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.	PLK1 BTRC	4.60e-05	4	97	2	16885021
Pubmed	PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation.	PLK1 BTRC	4.60e-05	4	97	2	25329897
Pubmed	Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.	A2M LRPAP1	4.60e-05	4	97	2	20637261
Pubmed	Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1.	PLK1 BTRC	4.60e-05	4	97	2	24501426
Pubmed	Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein.	AKAP13 MYOM2	4.60e-05	4	97	2	12972258
Pubmed	Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.	KMT2B TASP1	4.60e-05	4	97	2	34156981
Pubmed	The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis.	LAMA1 ITGA2	4.60e-05	4	97	2	7589890
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	HSPD1 DIP2B VWA8 ZNF618 SPTAN1 CHD7 NKRF DHX9 SPIN1 TSPYL5 CDK11B SPIN3	4.85e-05	1082	97	12	38697112
Pubmed	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.	ITGAX SARS1 AKAP13 FMNL1 NCKAP1L	5.21e-05	143	97	5	30397336
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	HSPD1 DIP2B SPTAN1 CPS1 PDIA4 MDN1 NCKAP1L	5.22e-05	344	97	7	30333137
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	A2M DIP2B SPTAN1 CFB DHX9 FMNL1 BTRC PRRC2B	5.70e-05	475	97	8	31040226
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	UBXN1 CDK14 DHX9 PDIA4 PANK2 SARS1 NUAK1 IKBKE TLE1 AKAP13 CDK11B FKBP4 SLC27A4	5.84e-05	1284	97	13	17353931
Pubmed	A human MAP kinase interactome.	HSPD1 SP100 ANK3 DCTN2 SPTAN1 COBL LRPAP1 AKAP13	6.69e-05	486	97	8	20936779
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HSPD1 DIP2B VWA8 EGLN1 TRIP11 NKRF DHX9 PDIA4 ACSL4 MDN1 SARS1 PLK1 FKBP4 PRRC2B	6.91e-05	1496	97	14	32877691
Pubmed	Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease.	A2M LRPAP1	7.66e-05	5	97	2	16650578
Pubmed	Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues.	A2M LRPAP1	7.66e-05	5	97	2	7514554
Pubmed	Phosphorylation of synucleins by members of the Polo-like kinase family.	SNCB PLK1	7.66e-05	5	97	2	19889641
Pubmed	The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan.	LAMA1 ITGA2	7.66e-05	5	97	2	9688542
Pubmed	The gene coding for the alpha 1 subunit of the skeletal dihydropyridine receptor (Cchl1a3 = mdg) maps to mouse chromosome 1 and human 1q32.	CACNA1S CRP	7.66e-05	5	97	2	8118099
Pubmed	The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.	PLK1 BTRC	7.66e-05	5	97	2	25453754
Pubmed	TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation.	EGLN1 TET3	7.66e-05	5	97	2	32963106
Pubmed	Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression.	PLK1 BTRC	7.66e-05	5	97	2	18378770
Pubmed	Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.	PLK1 BTRC	7.66e-05	5	97	2	18521620
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	CFB DNAJC17 IGF2R SARS1 GNAO1 BTRC PRRC2B	8.38e-05	371	97	7	15747579
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	HSPD1 A2M DCTN2 SPTAN1 ITGA2 UBXN1 PDIA4 ACSL4 MDN1	8.42e-05	647	97	9	26618866
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	HSPD1 ANK3 DCTN2 SPTAN1 RFC1 BANF1 DHX9 PDIA4 MDN1 SARS1 SPIN1 FKBP4	8.59e-05	1149	97	12	35446349
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SPTAN1 CHD7 RFC1 NKRF PDIA4 IGF2R MDN1 FKBP4 PRRC2B	9.03e-05	653	97	9	22586326
Pubmed	Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.	CACNA1S GNAO1	1.15e-04	6	97	2	24519419
Pubmed	Skp1-Cul1-F-box ubiquitin ligase (SCF(βTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry.	PLK1 BTRC	1.15e-04	6	97	2	23027877
Pubmed	HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.	PLK1 BTRC	1.15e-04	6	97	2	18794143
Pubmed	Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.	KMT2B TASP1	1.15e-04	6	97	2	24176642
Pubmed	Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.	PLK1 BTRC	1.15e-04	6	97	2	19822658
Pubmed	In vivo assembly of the axon initial segment in motor neurons.	ANK3 SPTAN1	1.15e-04	6	97	2	23728480
Pubmed	A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.	SPIN1 SPIN3	1.15e-04	6	97	2	29061846
Pubmed	Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.	PLK1 BTRC	1.15e-04	6	97	2	25503564
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	UBXN1 RFC1 BANF1 NKRF DHX9 DNAJC17 MDN1 UBN1 TLE1 CDK11B FKBP4	1.24e-04	1014	97	11	32416067
Pubmed	Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.	HSPD1 DCTN2 SPTAN1 DHX9 SPIN1	1.25e-04	172	97	5	23184937
Pubmed	Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.	DIP2B CPS1 LRPAP1	1.29e-04	35	97	3	23969696
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ERCC6 KMT2B DCTN2 CPS1 RFC1 NKRF DHX9 MDN1 COBL PLD1	1.30e-04	847	97	10	35850772
Pubmed	Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.	HSPD1 RETSAT LRPAP1 FKBP4 SLC27A4	1.31e-04	174	97	5	32149426
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2B ANK3 DCTN2 SPTAN1 NKRF SMG7 PLK1 PRRC2B	1.55e-04	549	97	8	38280479
Pubmed	Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.	ANK3 SPTAN1	1.60e-04	7	97	2	7495297
Pubmed	A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.	HSPD1 SPTAN1 DHX9	1.65e-04	38	97	3	18247557
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	HSPD1 DIP2B ANK3 SPTAN1 FSIP2 GNAO1 SNCB FKBP4	1.73e-04	558	97	8	35063084
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	HSPD1 VWA8 DCTN2 SPTAN1 RFC1 BANF1 NKRF MDN1 UBN1 COBL BTRC PRRC2B SLC27A4	1.83e-04	1440	97	13	30833792
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	LAMA1 ST6GALNAC3 AKAP13 NEK11	1.89e-04	101	97	4	18519826
Pubmed	Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.	PLK1 BTRC	2.13e-04	8	97	2	15469984
Pubmed	HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.	HSPD1 BANF1	2.13e-04	8	97	2	15875659
Pubmed	Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis.	LAMA1 ITGA2	2.13e-04	8	97	2	8725284
Pubmed	Beta1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells.	TNC LAMA1	2.13e-04	8	97	2	19633172
Pubmed	Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.	HSPD1 BTRC	2.13e-04	8	97	2	12684064
Pubmed	Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.	HSPD1 BANF1	2.13e-04	8	97	2	16075307
Pubmed	Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway.	EGLN1 FKBP4	2.13e-04	8	97	2	23413029
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	HSPD1 SPTAN1 CPS1 BANF1 DHX9 PDIA4 ACSL4 GNAO1	2.24e-04	580	97	8	35676659
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	HSPD1 DCTN2 SPTAN1 CHD7 DHX9 MDN1 UBN1 PLK1	2.30e-04	582	97	8	20467437
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	UBXN1 CDK14 RETSAT NUAK1 IKBKE RALBP1 ANKRD36 CDK11B PLK1 BTRC	2.31e-04	910	97	10	36736316
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	HSPD1 SPTAN1 UBXN1 RFC1 RETSAT DHX9 PDIA4 IGF2R LRPAP1 AKAP13 FKBP4 PRRC2B	2.64e-04	1297	97	12	33545068
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	HSPD1 LAMA1 RFC1 PLK1 PRRC2B	2.69e-04	203	97	5	22083510
Pubmed	The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.	PLK1 BTRC	2.74e-04	9	97	2	30554948
Pubmed	Detection of gelatinolytic activity in developing basement membranes of the mouse embryo head by combining sensitive in situ zymography with immunolabeling.	TNC LAMA1	2.74e-04	9	97	2	22688677
Pubmed	FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.	CFB CRP	2.74e-04	9	97	2	28533443
Pubmed	Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.	DCTN2 FKBP4	2.74e-04	9	97	2	15004035
Pubmed	The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.	EGLN1 PLD1	2.74e-04	9	97	2	26680696
Pubmed	Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice.	TNC LAMA1	2.74e-04	9	97	2	9882526
Pubmed	Targeted inactivation of the mouse alpha 2-macroglobulin gene.	A2M LRPAP1	2.74e-04	9	97	2	7544347
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	KMT2B TASP1	2.74e-04	9	97	2	16951254
Pubmed	Dynamic expression patterns of ECM molecules in the developing mouse olfactory pathway.	TNC LAMA1	2.74e-04	9	97	2	18570250
Interaction	RIPK4 interactions	HSPD1 SPAST ANK3 VWA8 PDIA4 MDN1 SARS1 SMG7 FKBP4 BTRC SLC27A4	8.10e-06	446	95	11	int:RIPK4
Cytoband	18p11.3	LAMA1 RALBP1	2.40e-04	11	97	2	18p11.3
GeneFamily	Tudor domain containing\|Spindlin family	SPIN1 SPIN3	1.23e-04	5	64	2	1089
GeneFamily	Doublecortin superfamily	DCDC1 RP1	5.45e-04	10	64	2	1369
GeneFamily	Zinc fingers CXXC-type	KMT2B TET3	7.96e-04	12	64	2	136
GeneFamily	AAA ATPases	SPAST RFC1 MDN1	8.73e-04	53	64	3	413
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA2 ITGAX	1.82e-03	18	64	2	1160
GeneFamily	Cyclin dependent kinases	CDK14 CDK11B	3.80e-03	26	64	2	496
GeneFamily	Acyl-CoA synthetase family	ACSL4 SLC27A4	3.80e-03	26	64	2	40
Coexpression	MURARO_PANCREAS_DUCTAL_CELL	A2M SP100 SAMD9 ANK3 SPTAN1 EGLN1 ITGA2 RETSAT CFB CRP ACSL4 OLFML2A IGF2R TLE1 AKR1B10 AKAP13 PLD1	4.10e-06	1276	97	17	M39173
Coexpression	MURARO_PANCREAS_BETA_CELL	HSPD1 CHD7 UBXN1 TRIP11 SARS1 UBN1 RRN3 SPIN1 SURF2 DIP2C TSPYL5 GNAO1 FKBP4 PRRC2B	9.99e-06	946	97	14	M39169
Coexpression	GSE9946_IMMATURE_VS_MATURE_STIMULATORY_DC_UP	ABRA SPAST RALBP1 TLE1 FMNL1 BTRC	1.22e-05	137	97	6	M415
Coexpression	KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP	HSPD1 GABRD DCTN2 SPTAN1 CDK14 SARS1 NUAK1 COBL LRPAP1 SNCB PRRC2B CREB3	2.27e-05	755	97	12	M2105
ToppCell	Severe-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CACNA1S SAMD9 ANK3 CDK14 ITGAX MYOM2	2.58e-06	178	97	6	b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	ZNF536 ANK3 PDIA4 MYOM2 SNCB RAB26	3.65e-06	189	97	6	3717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	HSPD1 SP100 SAMD9 GALM ANK3 ANKRD36	4.00e-06	192	97	6	e07b6892276c81c1227e94ca942f6820d89a7ca3
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_em-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	HSPD1 SP100 SAMD9 GALM ANK3 ANKRD36	4.24e-06	194	97	6	0b0042b6a356a49a059fb64a1e1abb25c82d48cf
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer\|World / Primary Cells by Cluster	ANK3 CHGA TLE1 GNAO1 SNCB RAB26	4.63e-06	197	97	6	41e823b14697827f657b13adb3afa581bd91a9cb
ToppCell	Macroglial-Oligodendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DIP2B ZNF536 ANK3 ITGA2 ST6GALNAC3 PLD1	5.05e-06	200	97	6	4dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCell	Macroglial-Oligodendrocytes-OPALIN--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DIP2B ZNF536 ANK3 ITGA2 ST6GALNAC3 PLD1	5.05e-06	200	97	6	26b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	A2M SP100 SAMD9 IGF2R NUAK1 MYOM2	5.05e-06	200	97	6	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Macroglial-Oligodendrocytes-OPALIN---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DIP2B ZNF536 ANK3 ITGA2 ST6GALNAC3 PLD1	5.05e-06	200	97	6	1314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCell	Macroglial-Oligodendrocytes-OPALIN-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DIP2B ZNF536 ANK3 ITGA2 ST6GALNAC3 PLD1	5.05e-06	200	97	6	8b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCell	Macroglial-Oligodendrocytes-OPALIN----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DIP2B ZNF536 ANK3 ITGA2 ST6GALNAC3 PLD1	5.05e-06	200	97	6	272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCell	Macroglial-Oligodendrocytes-OPALIN\|Macroglial / cells hierarchy compared to all cells using T-Statistic	DIP2B ZNF536 ANK3 ITGA2 ST6GALNAC3 PLD1	5.05e-06	200	97	6	5f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DIP2B ZNF618 TMEM168 MYOM2 ADSS1	2.41e-05	157	97	5	542944030cd9b3f3559e64f9f6598694d74003c0
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122\|Adult / Lineage, Cell type, age group and donor	ANK3 CFB ST6GALNAC3 AKAP13 RP1	2.41e-05	157	97	5	31d1bd9138c60e8485664ec4144f987226e3eef9
ToppCell	NS-critical-d_0-4-Lymphoid-B_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	USP45 TASP1 CHD7 FSIP2 ANKRD36	3.63e-05	171	97	5	bd1ebd9037a740ad8c01c460d778b0973d8b56df
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_NK-NK_CD16\|GI_small-bowel / Manually curated celltypes from each tissue	ITGAX IGF2R NUAK1 TLE1 MYOM2	3.74e-05	172	97	5	701de463f85aaad3a4b36a0d5fbc416406620089
ToppCell	10x_5'_v1-Neoplastic-Stem-like-OPC-like\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNC CPS1 COBL SNCB PLK1	4.06e-05	175	97	5	cc596907ea1a64ab7b5a8c7d4ad12e6ee59bfed9
ToppCell	10x_5'_v1-Neoplastic-Stem-like\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNC CPS1 COBL SNCB PLK1	4.06e-05	175	97	5	a8400e7e47379901dcab5f2e364c3ff17765b4b9
ToppCell	10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNC CPS1 COBL SNCB PLK1	4.06e-05	175	97	5	8a3abf40146ae3459d97cdf865c1c8f6b92ac639
ToppCell	10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNC CPS1 COBL SNCB PLK1	4.06e-05	175	97	5	378d2b79edac91fc74eee0fb42bb29dd9b07c36f
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	EGLN1 LAMA1 RETSAT DIP2C PLD1	4.76e-05	181	97	5	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TIGAR EGLN1 OLFML2A PANK2 SLC27A4	5.02e-05	183	97	5	3ef9ac1ae13b6172f9121ab1c129ecaa0fef460f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK3 CDK14 ST6GALNAC3 COBL RP1	5.15e-05	184	97	5	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	A2M EGLN1 ACSL4 DIP2C COBL	5.42e-05	186	97	5	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	A2M TNC ITGA2 OLFML2A NUAK1	5.56e-05	187	97	5	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK3 CHD7 ITGA2 COBL RAB26	5.56e-05	187	97	5	f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCell	5'-Adult-Appendix-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M GABRD ABRA TNC OLFML2A	5.85e-05	189	97	5	0daa8efac08dca9525d2b8d421952068cab4eb50
ToppCell	5'-Adult-Appendix-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M GABRD ABRA TNC OLFML2A	5.85e-05	189	97	5	b6bb4327b4560d07d2b728abcc5f144f428948a5
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	ABRA ANK3 DIP2C AKAP13 MYOM2	5.85e-05	189	97	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	ABRA ANK3 DIP2C AKAP13 MYOM2	5.99e-05	190	97	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-27\|World / Primary Cells by Cluster	CHD7 CHGA TLE1 SNCB RAB26	6.30e-05	192	97	5	cf989f26c0ebdc0cd12e1e41958f063e4fa3e468
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	DIP2B ANK3 CDK14 DIP2C AKAP13	6.30e-05	192	97	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DCDC1 ANK3 TNC ITGA2 RP1	6.46e-05	193	97	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	368C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	A2M TNC ITGA2 OLFML2A NUAK1	6.61e-05	194	97	5	d9eec28fa7b255c0ec023276dd955f1e276e7159
ToppCell	CV-Severe-6\|Severe / Virus stimulation, Condition and Cluster	DCTN2 SPTAN1 PANK2 LRPAP1 NCKAP1L	6.61e-05	194	97	5	d33be6ed1de907aeea0c2dce09796556b8efdd4e
ToppCell	368C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	A2M TNC ITGA2 OLFML2A NUAK1	6.61e-05	194	97	5	e4d7e9709ce42d4610e44d3445927eefbcbb9eff
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-G\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	A2M TNC OLFML2A NUAK1 LRPAP1	7.11e-05	197	97	5	a21a710c824f9e5c7ef1674168d1ce5aef85bd35
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TIGAR ITGAX GNAO1 FMNL1 NCKAP1L	7.28e-05	198	97	5	d73585a5587941483db8d9ddc2d68f7d852bbbc8
ToppCell	390C-Lymphocytic-NK_cells\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ITGAX BANF1 IGF2R TLE1 MYOM2	7.28e-05	198	97	5	623e5ada1a54cd42c32a1519b84dbe782384ee0c
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	A2M EGLN1 MDN1 NUAK1 AKAP13	7.28e-05	198	97	5	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TNC MYOM2 GNAO1 BTRC ADSS1	7.28e-05	198	97	5	cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	SAMD9 TRIP11 SPIN1 RALBP1 ANKRD36	7.46e-05	199	97	5	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPD1 CDX1 LAMA1 CPS1 REEP6	7.46e-05	199	97	5	722b9ebf7e47c361a7f192689a8d46947ec62b45
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPD1 CDX1 CPS1 REEP6 PLK1	7.46e-05	199	97	5	7816ad127b16208b1046da53f4a295b4a747b4cc
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	SP100 RFC1 TRIP11 RALBP1 ANKRD36	7.46e-05	199	97	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPD1 CDX1 LAMA1 CPS1 REEP6	7.46e-05	199	97	5	9d24223b571fba202455c5bd49bd79530abf09c0
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPD1 CDX1 CPS1 REEP6 PLK1	7.46e-05	199	97	5	06cf08b4a60670f583895a79488524b7b386b2f0
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	CHD7 TLE1 SNCB PLK1 RAB26	7.46e-05	199	97	5	8e72efcd421639ac36ed036ee13f13de070d361f
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	SP100 SAMD9 CHD7 RFC1 TRIP11	7.46e-05	199	97	5	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	ANK3 SPTAN1 CHGA GNAO1 SNCB	7.64e-05	200	97	5	e9eb348a66011d8aace4331f84690ae27cb0d061
ToppCell	background-Hepatocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	A2M CPS1 CFB CRP REEP6	7.64e-05	200	97	5	423cca10df6ae0489a8fe7e7df87e70364dac022
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	CHD7 TLE1 SNCB PLK1 RAB26	7.64e-05	200	97	5	7c495030e6566b81d97b5516d1972e335ce5ed8c
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	A2M GABRD CDX1 TNC OLFML2A	7.64e-05	200	97	5	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	A2M SAMD9 FSIP2 OLFML2A PLD1	7.64e-05	200	97	5	aafe594c88710f8c53d59667cdac5035e08f5511
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	ANK3 SPTAN1 OLFML2A GNAO1 PRRC2B	7.64e-05	200	97	5	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	SPTAN1 CHGA ACSL4 GNAO1 SNCB	7.64e-05	200	97	5	44bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SP100 SAMD9 ANK3 SPTAN1 MDN1	7.64e-05	200	97	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	COVID-19_Mild-NK\|COVID-19_Mild / Disease condition and Cell class	ITGAX IGF2R TLE1 MYOM2 FMNL1	7.64e-05	200	97	5	b586b0f1127293c2f8529be16b24229359041da2
ToppCell	COVID-19_Severe-NK_activated\|COVID-19_Severe / Disease condition and Cell class	SP100 SAMD9 ITGAX TLE1 MYOM2	7.64e-05	200	97	5	f1f6c7f7f75f891c9ccf6bf58f4d65b9cf10bbd8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	A2M SAMD9 FSIP2 OLFML2A PLD1	7.64e-05	200	97	5	a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Neuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	DCTN2 CHD7 CHGA SNCB RAB26	7.64e-05	200	97	5	b5019b9d48f32cffd4645a5c0f3e0ac504ea8019
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA8 EGLN1 ITGAX CDK11B	1.09e-04	113	97	4	357bc20edc5bc14eab8262d52260ed1686e9dc54
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA8 EGLN1 ITGAX CDK11B	1.09e-04	113	97	4	91e73e3b93be242fef0f14eddd8085a1f1c730ef
Computational	Genes in the cancer module 412.	TNC ITGA2 ITGAX	5.26e-05	13	63	3	MODULE_412
Drug	Nomifensine maleate [32795-47-4]; Up 200; 11.2uM; PC3; HT_HG-U133A	SAMD9 KMT2B TNC DCTN2 MDN1 COBL RAB26 NEK11	1.81e-06	196	96	8	5863_UP
Drug	tripropargylamine	ABRA ITGA2	1.76e-05	2	96	2	CID000023351
Drug	Diethylstilbestrol [56-53-1]; Down 200; 15uM; HL60; HT_HG-U133A	SPTAN1 ITGA2 UBXN1 CPS1 ITGAX TRIP11 NCKAP1L	1.78e-05	193	96	7	2567_DN
Drug	Dicyclomine hydrochloride [67-92-5]; Down 200; 11.6uM; PC3; HT_HG-U133A	SP100 ANK3 TNC DHX9 TLE1 PLD1 BTRC	1.90e-05	195	96	7	4581_DN
Drug	Demeclocycline hydrochloride [64-73-3]; Down 200; 8uM; MCF7; HT_HG-U133A	SPAST TRIP11 DHX9 SMG7 IKBKE TLE1 AKAP13	1.96e-05	196	96	7	4728_DN
Drug	PHA-00767505E [723337-45-9]; Down 200; 10uM; PC3; HT_HG-U133A	SAMD9 SPTAN1 CHD7 UBXN1 COBL RAB26 NEK11	1.96e-05	196	96	7	6591_DN
Drug	5194442; Down 200; 20uM; PC3; HT_HG-U133A	SP100 ANK3 UBXN1 SMG7 IKBKE RAB26 NEK11	2.03e-05	197	96	7	6594_DN
Drug	Norethynodrel [68-23-5]; Down 200; 13.4uM; PC3; HT_HG-U133A	ANK3 UBXN1 TRIP11 NKRF ACSL4 IKBKE AKAP13	2.10e-05	198	96	7	1818_DN
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; MCF7; HT_HG-U133A	SP100 CDX1 SAMD9 TNC CPS1 ITGAX GNAO1	2.10e-05	198	96	7	3550_UP
Disease	Liver carcinoma	A2M GABRD KMT2B CDK14 CRP ACSL4 OLFML2A IGF2R AKR1B10 GNAO1 PLK1	6.61e-07	507	94	11	C2239176
Disease	Infection	SAMD9 CRP	2.09e-04	7	94	2	C3714514
Disease	Endotoxemia	HSPD1 CPS1	2.78e-04	8	94	2	C0376618
Disease	juvenile rheumatoid arthritis (is_marker_for)	HSPD1 CRP	2.78e-04	8	94	2	DOID:676 (is_marker_for)
Disease	symmetrical dimethylarginine measurement	ST6GALNAC3 AKR1B10	3.56e-04	9	94	2	EFO_0006523
Disease	end stage renal disease (is_marker_for)	CHGA CFB CRP	4.30e-04	46	94	3	DOID:783 (is_marker_for)
Disease	neuroimaging measurement	HSPD1 DIP2B SAMD9 KMT2B DCDC1 ANK3 CHD7 CFB NUAK1 GNAO1 PLD1	5.94e-04	1069	94	11	EFO_0004346
Disease	uric acid measurement	DCDC1 CPS1 BANF1 SPIN1 DIP2C AKAP13 GNAO1 PRRC2B	7.46e-04	610	94	8	EFO_0004761
Disease	membranous glomerulonephritis (biomarker_via_orthology)	A2M LRPAP1	8.91e-04	14	94	2	DOID:10976 (biomarker_via_orthology)
Disease	eosinophil percentage of granulocytes	CHD7 CHGA CPS1 AKAP13 GNAO1	9.30e-04	234	94	5	EFO_0007996
Disease	quinate measurement	ITGA2 CFB	1.03e-03	15	94	2	EFO_0021167
Disease	breast carcinoma (is_marker_for)	CRP IGF2R PLK1	1.24e-03	66	94	3	DOID:3459 (is_marker_for)
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	DIP2B KMT2B	1.32e-03	17	94	2	DOID:0060307 (is_implicated_in)
Disease	Age-related macular degeneration	ERCC6 CFB	1.49e-03	18	94	2	cv:C0242383
Disease	fibrinogen measurement, coronary artery disease	DIP2B CPS1 IGF2R GNAO1	1.51e-03	154	94	4	EFO_0001645, EFO_0004623
Disease	metabolite measurement, diet measurement	CPS1 RRN3 GNAO1	1.53e-03	71	94	3	EFO_0004725, EFO_0008111
Disease	polycystic kidney disease (biomarker_via_orthology)	TNC CFB	1.66e-03	19	94	2	DOID:0080322 (biomarker_via_orthology)
Disease	Omenn Syndrome	CHD7 DCLRE1C	1.66e-03	19	94	2	C2700553
Disease	Pheochromocytoma	EGLN1 CHGA	1.66e-03	19	94	2	C0031511
Disease	myocardial infarction (biomarker_via_orthology)	HSPD1 TNC EGLN1 CRP	1.74e-03	160	94	4	DOID:5844 (biomarker_via_orthology)
Disease	Lewy Body Disease	IGF2R SNCB	2.23e-03	22	94	2	C0752347
Disease	prostate carcinoma (is_marker_for)	SARS1 PLK1	2.43e-03	23	94	2	DOID:10286 (is_marker_for)
Disease	frailty measurement	ANK3 GNAO1	2.43e-03	23	94	2	EFO_0009885
Disease	Dystonia	ERCC6 KMT2B PANK2	2.65e-03	86	94	3	C0013421
Disease	chronic hepatitis B virus infection	CFB GNAO1	2.65e-03	24	94	2	EFO_0004239
Disease	eosinophil percentage of leukocytes	KMT2B CHD7 CHGA CPS1 IKBKE AKAP13 GNAO1 TET3	2.65e-03	746	94	8	EFO_0007991
Disease	cortical thickness	A2M DIP2B ZNF536 KMT2B DCDC1 LAMA1 CHD7 SMG7 UBN1 NUAK1	2.88e-03	1113	94	10	EFO_0004840
Disease	macular degeneration (is_marker_for)	ERCC6 CRP	3.10e-03	26	94	2	DOID:4448 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KGDIPEGYSVSREKK	TRBV28	76	A0A5B6
AVSKFGKKDSLGTRE	ACSL4	86	O60488
GGSGKTRTKDKYRVV	CDX1	146	P47902
NKRIVSGAYDGKIKV	BTRC	516	Q9Y297
GAVDSKVASYEKKVR	AKAP13	2186	Q12802
GKVKEAVKVAIDAGY	AKR1B10	26	O60218
DSVLNIARGKKYGEK	ANKRD36	1071	A6QL64
IARGKKYGEKTKRVS	ANKRD36	1076	A6QL64
EGTYGVVYRAKDKKT	CDK11B	446	P21127
KADSYEKLEKLGEGS	CDK14	131	O94921
RSIAKEGFEKISKGA	HSPD1	121	P10809
KYGLDGKKDARQVTS	LRPAP1	121	P30533
DRIGKTKRTGYESGE	DCTN2	71	Q13561
SKKEIEDLLRKGAYG	CHD7	1456	Q9P2D1
GSYKVVVQKKSGGRT	A2M	201	P01023
YRVSGIKSKVDELKA	RALBP1	231	Q15311
VVKREDGEKLAKEYG	RAB26	186	Q9ULW5
TRGRKVQKEGKISYA	PPP2R3B	361	Q9Y5P8
VITDGKKEGDSLDYK	ITGAX	256	P20702
TRKEVYIKNGDKKGS	CFB	641	P00751
KKERGTFDYRIDGKG	ERCC6	861	P0DP91
IRVKAAEGTSLEGYK	DCDC1	726	M0R2J8
YTALRKESGTKLVDG	MDN1	941	Q9NU22
ASVYKARNKKSGELV	IKBKE	21	Q14164
EKEVLGSDSEIGYKK	FSIP2	5596	Q5CZC0
LSEGDITQKGYEKKR	DIP2B	31	Q9P265
GTVYLVSDKKAKRGE	NEK11	41	Q8NG66
SLKGYGKRVADIKES	NCKAP1L	311	P55160
YRSVGVETGETKKEG	GABRD	391	O14764
SVLTDKREKFYDGKG	KMT2B	2611	Q9UMN6
KKEEGRVYLFTIKEG	ITGA2	521	P17301
GDSTKVDKLVRDIYG	PANK2	441	Q9BZ23
VLGALEAKTGVEKRY	REEP6	21	Q96HR9
NRIAKGTFKVDGKEY	GALM	81	Q96C23
IAEVSTKDVKVYGKG	CPS1	201	P31327
YEKLATGESIAVKKR	DCLRE1C	671	Q96SD1
GVLSGEFTKEREKAK	CACNA1S	331	Q13698
KVKDKVYGCADGERT	COBL	646	O75128
RKSLKKGYTVGAEAS	CRP	136	P02741
LSEGDITQKGYEKKR	DIP2C	26	Q9Y2E4
SKIYKDVSENGVGKV	ANK3	2516	Q12955
KEDESKGGYSKDVLL	DNAJC17	181	Q9NVM6
RARAKVKYLTGEKGV	EGLN1	396	Q9GZT9
KLKSYVDTGGVSRKV	FMNL1	86	O95466
RVSVRKELKGGKAYA	FAM102B	81	Q5T8I3
TIVKERGTVYFKEGK	FKBP4	271	Q02790
GKKLEERGFDKAYVV	BANF1	31	O75531
ESRRKKKVYVGGLES	CREB3	166	O43889
VEAYSGLTKKKEGET	DHX9	256	Q08211
ARGKGKDISKYGSVQ	OLFML2A	226	Q68BL7
GFVKRAIEKLYGKAD	RP1	1626	P56715
GATDGKKRYDLSALV	IGF2R	476	P11717
AELKGKRGSDYETFK	RETSAT	476	Q6NUM9
VDGKVDNGKTKDLYR	RRN3	331	Q9NYV6
ELYKVIGKGSEKSDD	SARS1	246	P49591
EKTKEGVLYVGSKTR	SNCB	31	Q16143
KYGVVEGKALSELRA	TIGAR	91	Q9NQ88
GEVKVGVSYKLNGKR	ADSS1	371	Q8N142
EAVGVKKTVKYEAAG	NKRF	491	O15226
VGKKETETKYGIRID	PLD1	286	Q13393
ERYGGKVTGNVSKKT	RFC1	431	P35251
KASKEEDFYRGGKVS	SAMD9	676	Q5K651
KTDYVKRKGFITVDG	LAMA1	2801	P25391
LGIEYGDKERKADAK	GNAO1	91	P09471
RDYSKGITVTKNDGK	SMG7	571	Q92540
KKETGKDRVQSGSYL	ST6GALNAC3	201	Q8NDV1
LGKGTYGKVKRATER	NUAK1	61	O60285
KILKKGQAVDYEGSR	PDIA4	141	P13667
ETTVYRGLVQKRGKK	SURF2	216	Q15527
LTSKYVGEGEKLVRA	SPAST	411	Q9UBP0
YGRPKEGTKTAERAK	ABRA	286	Q8N0Z2
GYKEIRKGESRSEAL	CHGA	261	P10645
DKYIVTGSGDKKATV	TLE1	751	Q04724
IKSYVLGVKGADIRD	ZNF618	576	Q5T7W0
DETRKKVKAYGKEGV	USP45	331	Q70EL2
GEKSVKYKERGKAFT	ZNF519	261	Q8TB69
ESGKKEYSLDTRGKF	WDR61	136	Q9GZS3
TGTYKFQKTELRKEG	SLC27A4	591	Q6P1M0
SGELIGEYEEKKRKL	SMC1B	161	Q8NDV3
KQVEYAKEDGSKRTG	SPIN1	216	Q9Y657
GKQVEYAKDDGSKRT	SPIN3	211	Q5JUX0
KEKKLLVGSEDYGRD	SPTAN1	1781	Q13813
EVKGTLYKERFKQGT	SP100	611	P23497
SVGDAKTRYKLKVEG	TNC	2091	P24821
KYKGKSVDAIRSSVI	PRRC2B	26	Q5JSZ5
TEKGRTVKAVYGVSK	TMEM168	606	Q9H0V1
RIEKVIYTGKEGKSS	TET3	871	O43151
DKAERAKKYGGSVGS	UBXN1	171	Q04323
KEKREYVLVGADGSK	ZNF536	561	O15090
EVKKRLDSEYKEGGQ	TMEM19	116	Q96HH6
AGSYVRAASEKRVKK	WFIKKN1	516	Q96NZ8
LKGENEKIVETYRGK	TRIP11	1461	Q15643
VEALARKFEEKYGGK	UBN1	101	Q9NPG3
GTDTSFYRGKKKRGT	VWA8	1396	A3KMH1
AEKRKRTTGAKYGDV	TIGD7	66	Q6NT04
ETKQSYKEKRGGFVL	TASP1	31	Q9H6P5
KGDIAEGYSVSREKK	TRBV19	76	A0A075B6N1
YLLSEGARVEKGKEK	TSPYL5	381	Q86VY4
GLATKVEYDGERKKT	PLK1	196	P53350
KNKYGGEKIDVTVSV	MYOM2	1421	P54296