Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleobase binding	DPYD APRT	1.01e-04	5	64	2	GO:0002054
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	MYO3A KANK1 USP17L2 TTLL3 MCIDAS TBC1D5 STIL CCDC57 BBS9 RAC1	3.80e-05	670	64	10	GO:0120031
GeneOntologyBiologicalProcess	cell projection assembly	MYO3A KANK1 USP17L2 TTLL3 MCIDAS TBC1D5 STIL CCDC57 BBS9 RAC1	4.58e-05	685	64	10	GO:0030031
Domain	BIR	BIRC2 BIRC6	2.90e-04	8	61	2	SM00238
Domain	-	BIRC2 BIRC6	2.90e-04	8	61	2	1.10.1170.10
Domain	BIR	BIRC2 BIRC6	2.90e-04	8	61	2	PF00653
Domain	BIR_REPEAT_2	BIRC2 BIRC6	2.90e-04	8	61	2	PS50143
Domain	BIR_rpt	BIRC2 BIRC6	2.90e-04	8	61	2	IPR001370
Domain	BIR_REPEAT_1	BIRC2 BIRC6	2.90e-04	8	61	2	PS01282
Domain	-	PIAS4 DPPA2	2.12e-03	21	61	2	1.10.720.30
Domain	SAP	PIAS4 DPPA2	2.54e-03	23	61	2	SM00513
Domain	SAP	PIAS4 DPPA2	3.00e-03	25	61	2	PS50800
Domain	SAP_dom	PIAS4 DPPA2	3.00e-03	25	61	2	IPR003034
Domain	-	BIRC2 LRRD1 NLRP8	3.49e-03	93	61	3	1.10.533.10
Domain	-	CARMIL3 FBXL12 LRRD1 NLRP8 LRRC47	3.94e-03	321	61	5	3.80.10.10
Domain	DEATH-like_dom	BIRC2 LRRD1 NLRP8	4.16e-03	99	61	3	IPR011029
Domain	L_dom-like	CARMIL3 FBXL12 LRRD1 NLRP8 LRRC47	4.31e-03	328	61	5	IPR032675
Pubmed	PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway.	PTPN1 RAC1	1.03e-05	3	65	2	27052191
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20HL2	1.03e-05	3	65	2	24220028
Pubmed	IAPs: more than just inhibitors of apoptosis proteins.	BIRC2 BIRC6	2.06e-05	4	65	2	18414036
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	EIF2D TBC1D5 PKD1L1 PPP1R13B STIL PHF8 GTPBP1 APRT CCDC57	2.88e-05	853	65	9	28718761
Pubmed	Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation.	BIRC2 BIRC6	3.43e-05	5	65	2	20957035
Pubmed	Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.	KANK1 RAC1	3.43e-05	5	65	2	19171758
Pubmed	IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.	BIRC2 RAC1	5.13e-05	6	65	2	22117219
Pubmed	The inhibitors of apoptosis (IAPs) and their emerging role in cancer.	BIRC2 BIRC6	7.18e-05	7	65	2	9916987
Pubmed	The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.	BIRC2 BIRC6	7.18e-05	7	65	2	15640352
Pubmed	IAP family proteins--suppressors of apoptosis.	BIRC2 BIRC6	7.18e-05	7	65	2	9990849
Pubmed	Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.	SUPT20HL1 SUPT20HL2	9.56e-05	8	65	2	21802298
Pubmed	AMPylation of Rho GTPases subverts multiple host signaling processes.	BIRC2 RAC1	9.56e-05	8	65	2	25301945
Pubmed	cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation.	BIRC2 RAC1	9.56e-05	8	65	2	24276241
Pubmed	Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.	PIAS4 UBA2	1.23e-04	9	65	2	21931855
Pubmed	CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.	PIAS4 UBA2	1.23e-04	9	65	2	16679534
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	PTPN1 UBR4 UBA2	1.79e-04	58	65	3	31067491
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	SUPT20HL1 SUPT20HL2	1.87e-04	11	65	2	24051374
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	KLHDC3 UBR4 BIRC2	2.18e-04	62	65	3	18775313
Pubmed	Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.	SCN10A RAC1	2.65e-04	13	65	2	35263589
Pubmed	JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice.	JADE2 RAC1	2.65e-04	13	65	2	36008159
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	FLACC1 SPATA4	3.08e-04	14	65	2	17662146
Pubmed	Chloride channels regulate differentiation and barrier functions of the mammalian airway.	MCIDAS PRR18	3.56e-04	15	65	2	32286221
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	EXD2 UBR4 BIRC2 DHTKD1 BIRC6 RAC1	4.04e-04	515	65	6	31617661
Pubmed	Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition.	PIAS4 DPPA2	4.59e-04	17	65	2	33634103
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF19 ZNF142	4.59e-04	17	65	2	7557990
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	PIAS4 PTPN1 CHAF1B PCGF2 BRDT PHF8	4.84e-04	533	65	6	30554943
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	ZNF142 JADE2 TBC1D5	5.14e-04	83	65	3	9039502
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	SUPT20HL1 ZNF335 IREB2 SUPT20HL2 BIRC6	5.96e-04	363	65	5	14691545
Pubmed	Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation.	SUPT20HL1 SUPT20HL2	7.06e-04	21	65	2	23747598
Pubmed	Supt20 is required for development of the axial skeleton.	SUPT20HL1 SUPT20HL2	7.06e-04	21	65	2	27894818
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PABIR1 PTPN1 AKAP5 TBC1D5 FBXL12 PPP1R13B PHF8 BIRC6	7.35e-04	1049	65	8	27880917
Pubmed	p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.	SUPT20HL1 SUPT20HL2	7.76e-04	22	65	2	16751104
Pubmed	OTUB1 modulates c-IAP1 stability to regulate signalling pathways.	UBR4 BIRC2	9.24e-04	24	65	2	23524849
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A19 FAM90A18	1.00e-03	25	65	2	17684299
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	PIAS4 CHAF1B PHF8	1.05e-03	106	65	3	19394292
Pubmed	The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.	SUPT20HL1 SUPT20HL2	1.26e-03	28	65	2	19114550
Pubmed	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.	TDRD5 THSD7A	1.26e-03	28	65	2	25993318
Pubmed	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	SUPT20HL1 SUPT20HL2	1.45e-03	30	65	2	18206972
Pubmed	The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.	UBR4 UBA2	1.65e-03	32	65	2	36278411
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	SUPT20HL1 SUPT20HL2	1.75e-03	33	65	2	11564863
Cytoband	Xp22.11	SUPT20HL1 SUPT20HL2	4.07e-04	21	65	2	Xp22.11
GeneFamily	Ring finger proteins\|Baculoviral IAP repeat containing\|Caspase recruitment domain containing	BIRC2 BIRC6	6.91e-05	8	29	2	419
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	VWA3A MYO3A MCIDAS STIL SPATA4	8.33e-06	195	63	5	e525b69145059b66417589601f7109af63730f3a
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VWA3A MYO3A MCIDAS DPPA2 STIL	8.97e-06	198	63	5	f31790442ef142f1c0c49bf3daf2d0efb193d2c9
Disease	Global developmental delay	ZNF142 PCGF2 ZNF335 RAC1	1.69e-04	133	61	4	C0557874
Disease	cigarettes per day measurement	PIAS4 ZNF19 THSD7A JADE2 PPP1R13B IREB2	2.88e-04	438	61	6	EFO_0006525
Disease	hematologic cancer (implicated_via_orthology)	PIAS4 UBA2	3.23e-04	13	61	2	DOID:2531 (implicated_via_orthology)
Disease	Autosomal recessive primary microcephaly	ZNF335 STIL	4.34e-04	15	61	2	cv:C3711387
Disease	smoking cessation	DPYD JADE2 EXD2 IREB2 BIRC6	5.64e-04	325	61	5	EFO_0004319
Disease	cognitive function measurement	IL34 DPYD ZNF19 MYO3A THSD7A EXD2 TBC1D5 ZNF335 IREB2 BIRC6	6.67e-04	1434	61	10	EFO_0008354
Disease	skin hydration measurement	IL34 PKD1L1	8.61e-04	21	61	2	EFO_0009586
Disease	Obesity	PTPN1 DPYD ZFR2 BBS9	8.66e-04	205	61	4	C0028754
Disease	anxiety disorder	THSD7A PKD1L1	1.76e-03	30	61	2	EFO_0006788
Disease	keratinocyte carcinoma	KANK1 FLACC1 RAC1	1.89e-03	118	61	3	EFO_0010176
Disease	Developmental delay (disorder)	ZNF335 RAC1	2.67e-03	37	61	2	C0424605

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPPDAVPNKKLCRLP	TDRD5	451	Q8NAT2
EIVKCKPPPDIRNGR	C4BPA	171	P04003
LPGQEPIVKKGRICP	EIF2D	476	P41214
PKPGTLVQCLRLPKF	BIRC6	711	Q9NR09
VSACLRKRPLKPPAK	BRDT	571	Q58F21
QRLLKSPGCRKIPVL	GTPBP1	326	O00178
RKNLKRPIAHLPCPG	CHAF1B	271	Q13112
PLKRNCFIPKRPIPT	DPYD	906	Q12882
KQLACKLRLVGRPPL	DHTKD1	881	Q96HY7
VPKNLLGLYPRIKPR	PPP1R13B	1071	Q96KQ4
LGCVLIRKRGKLPGP	APRT	81	P07741
VKVAPKRPPKRFGCC	RAB44	1006	Q7Z6P3
EAIRAVLCPPPVKKR	RAC1	171	P63000
LSPLKVQPKKLPCRG	IREB2	156	P48200
GLRKKRRPCHDPAPL	FGFBP3	116	Q8TAT2
RPPKRILEPHNGKCR	PTPN1	311	P18031
PLLRPPVEICKGKQL	LRRD1	731	A4D1F6
NLGPRKLIKTPQLPR	FLACC1	16	Q96Q35
RKLGLPPVSPRDCVK	FAM149A	436	A5PLN7
CLLLPKRPQGRQPKT	NLRP8	191	Q86W28
ARPPQDLKIVPLGRK	LRRC47	391	Q8N1G4
EAPLPPLQKKRRRGL	CARMIL3	1041	Q8ND23
VRLPKLICGGKTLPR	EXD2	136	Q9NVH0
QPKCLLCPKRGGALK	JADE2	251	Q9NQC1
LNIQKRRKPSVPCPE	KANK1	61	Q14678
LGKLIGKVAVPCPRP	OR1I1	301	O60431
INCIRPSVLGPLKRK	PABIR1	191	Q96E09
APIQACLKFPKKPRL	FAM90A19	296	P0DV76
KFRLPLKLICLPGQP	BBS9	526	Q3SYG4
PGRALLCKPGKPERK	MCIDAS	26	D6RGH6
GPLPLKYRVQPACKR	PCGF2	221	P35227
APGPNLKLVRPKALL	IL34	151	Q6ZMJ4
PPARCPRRALHKQKD	MRPL58	21	Q14197
KIPCIKFPRGPKRSN	AKAP5	126	P24588
PAKAKGCQRPPKIRN	CCDC57	896	Q2TAC2
KPRACGTPDRPKALK	CCDC85A	261	Q96PX6
IEPKGKGPCPRRRQC	KLHDC3	281	Q9BQ90
QLKVFPRHLCKPPRP	PKD1L1	2381	Q8TDX9
PCAAGDKKKRPPQRP	PRR18	26	Q8N4B5
TAPQKARCKIPALPL	DPPA2	71	Q7Z7J5
QKRKRGPGLPLVPQA	RUSC1	321	Q9BVN2
PLLCGKIRPRKKARQ	SUPT20HL1	361	Q3ZLR7
LPKRPPCKARRRLFQ	PRR23A	251	A6NEV1
LRPETVRPCLLPCKK	THSD7A	756	Q9UPZ6
PALLRALGQKCPNLK	FBXL12	91	Q9NXK8
QPNPRKKLLVPCALD	UBA2	421	Q9UBT2
PLLCGKIRPRKKARQ	SUPT20HL2	361	P0C7V6
APSLRKCPICRGIIK	BIRC2	596	Q13490
PQLAAPIRGRPKKCL	SPATA4	26	Q8NEY3
KPALLRHCKVRQPPA	STIL	496	Q15468
SKLPRPKAGPRQLQL	ZFR2	256	Q9UPR6
NIQGKVPRIPCARKP	ZNF19	146	P17023
PRPQLDLKACNQLPK	SCN10A	51	Q9Y5Y9
ILKPRKAPALLCLRG	TTLL3	636	Q9Y4R7
KPGVEPKRPCRPINL	PIAS4	231	Q8N2W9
GPQKTLKRPKACSPR	nan	201	Q8N9P0
RPKFPRKLPRAKPCS	PHF8	671	Q9UPP1
LKALFLRDPKRNPRP	TBC1D5	406	Q92609
VLLRKNKGLPRPDSP	ZNF142	891	P52746
RKPPAPKQRVRFLLG	TRUB2	41	O95900
CLRILQKLIKPPAPT	UBR4	4016	Q5T4S7
KSPKPLLRPFLCRIC	ZNF335	456	Q9H4Z2
APVARQLAPRKKLPL	USP17L2	56	Q6R6M4
TLQLRSQPKKLCPPR	VWA3A	741	A6NCI4
APIQACLKFPKKPRL	FAM90A18	296	P0DV75
VCKGEEPKILRPPRR	MYO3A	1481	Q8NEV4