Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	succinyl-CoA metabolic process	NUDT7 NUDT8 DLST	1.57e-05	11	96	3	GO:0006104
GeneOntologyBiologicalProcess	propionyl-CoA catabolic process	NUDT7 NUDT8	2.14e-05	2	96	2	GO:1902859
GeneOntologyBiologicalProcess	butyryl-CoA catabolic process	NUDT7 NUDT8	6.41e-05	3	96	2	GO:0044580
GeneOntologyBiologicalProcess	acetyl-CoA catabolic process	NUDT7 NUDT8	6.41e-05	3	96	2	GO:0046356
GeneOntologyBiologicalProcess	medium-chain fatty-acyl-CoA catabolic process	NUDT7 NUDT8	1.28e-04	4	96	2	GO:0036114
GeneOntologyBiologicalProcess	propionyl-CoA metabolic process	NUDT7 NUDT8	1.28e-04	4	96	2	GO:1902858
GeneOntologyBiologicalProcess	malonyl-CoA catabolic process	NUDT7 NUDT8	1.28e-04	4	96	2	GO:2001294
Domain	DUF4592	CRACD CRACDL	7.49e-05	3	94	2	IPR028030
Domain	DUF4592	CRACD CRACDL	7.49e-05	3	94	2	PF15262
Domain	TSP_1	ADAMTS19 SSPOP SEMA5B ADAMTSL2	2.86e-04	63	94	4	PF00090
Domain	TSP1	ADAMTS19 SSPOP SEMA5B ADAMTSL2	3.22e-04	65	94	4	SM00209
Domain	TSP1_rpt	ADAMTS19 SSPOP SEMA5B ADAMTSL2	3.22e-04	65	94	4	IPR000884
Domain	TSP1	ADAMTS19 SSPOP SEMA5B ADAMTSL2	3.22e-04	65	94	4	PS50092
Domain	PDZ	MAST2 RGS3 MAGI2 RADIL AHNAK2	7.32e-04	141	94	5	PF00595
Domain	PDZ	MAST2 RGS3 MAGI2 RADIL AHNAK2	9.10e-04	148	94	5	SM00228
Domain	-	MAST2 RGS3 MAGI2 RADIL AHNAK2	9.66e-04	150	94	5	2.30.42.10
Domain	PDZ	MAST2 RGS3 MAGI2 RADIL AHNAK2	9.95e-04	151	94	5	PS50106
Domain	PDZ	MAST2 RGS3 MAGI2 RADIL AHNAK2	1.03e-03	152	94	5	IPR001478
Domain	6-hairpin_glycosidase-like	PHKB MOGS	1.89e-03	13	94	2	IPR008928
Domain	PLAC	ADAMTS19 ADAMTSL2	2.19e-03	14	94	2	PF08686
Domain	TIL_dom	SSPOP LRP2	2.19e-03	14	94	2	IPR002919
Domain	OAR	SHOX2 PRRX2	2.52e-03	15	94	2	PF03826
Domain	OAR	SHOX2 PRRX2	2.87e-03	16	94	2	PS50803
Domain	OAR_dom	SHOX2 PRRX2	2.87e-03	16	94	2	IPR003654
Domain	PLAC	ADAMTS19 ADAMTSL2	4.05e-03	19	94	2	PS50900
Domain	PLAC	ADAMTS19 ADAMTSL2	4.05e-03	19	94	2	IPR010909
Domain	ConA-like_dom	MEFV CELSR1 NPTXR MDGA1 RFPL2	5.00e-03	219	94	5	IPR013320
Domain	ADAM_spacer1	ADAMTS19 ADAMTSL2	5.92e-03	23	94	2	IPR010294
Domain	ADAM_spacer1	ADAMTS19 ADAMTSL2	5.92e-03	23	94	2	PF05986
Domain	NUDIX_BOX	NUDT7 NUDT8	6.44e-03	24	94	2	PS00893
Domain	NUDIX	NUDT7 NUDT8	6.44e-03	24	94	2	PF00293
Domain	Peptidase_M12B_ADAM-TS	ADAMTS19 ADAMTSL2	6.44e-03	24	94	2	IPR013273
Domain	EGF_3	RELN SSPOP CELSR1 LRP2 NOTCH4	6.70e-03	235	94	5	PS50026
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS19 SSPOP SEMA5B NOTCH4 ADAMTSL2	9.20e-06	68	59	5	M27303
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 SSPOP SEMA5B ADAMTSL2	2.04e-05	39	59	4	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 SSPOP SEMA5B ADAMTSL2	2.04e-05	39	59	4	MM15165
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS19 SSPOP MOGS SEMA5B NOTCH4 ADAMTSL2	2.84e-05	143	59	6	M27275
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TET2 MAST2 SSPOP PPP1R26 MAGI2 TSPYL4 BAHCC1	9.03e-08	130	98	7	12421765
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	MAST2 RGS3 MAGI2 RADIL	2.90e-06	35	98	4	33864728
Pubmed	Dopa-responsive dystonia or early-onset Parkinson disease - Genotype-phenotype correlation.	GCH1 PRKN	7.86e-06	2	98	2	27667361
Pubmed	Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia.	TET2 KDM6B	7.86e-06	2	98	2	35697791
Pubmed	The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.	SYT11 PRKN	7.86e-06	2	98	2	12925569
Pubmed	Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.	SYT11 PRKN	7.86e-06	2	98	2	29311685
Pubmed	Parkin-dependent and -independent degradation of synaptotagmin-11 in neurons and astrocytes.	SYT11 PRKN	7.86e-06	2	98	2	32976921
Pubmed	The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives.	NUDT7 NUDT8	7.86e-06	2	98	2	11415433
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	SSPOP CELSR1 MDGA1	9.63e-06	15	98	3	20473291
Pubmed	Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease.	GCH1 SYT11	2.35e-05	3	98	2	34674384
Pubmed	Low frequency of Parkin, Tyrosine Hydroxylase, and GTP Cyclohydrolase I gene mutations in a Danish population of early-onset Parkinson's Disease.	GCH1 PRKN	2.35e-05	3	98	2	16643317
Pubmed	CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis.	GCH1 PRRX2	2.35e-05	3	98	2	36266731
Pubmed	Molecular analyses of GCH-1, TH and parkin genes in Chinese dopa-responsive dystonia families.	GCH1 PRKN	2.35e-05	3	98	2	18554280
Pubmed	MicroRNA22-5p targets ten-eleven translocation and regulates estrogen receptor 2 expression in infertile women with minimal/mild endometriosis during implantation window.	TET2 ESR2	2.35e-05	3	98	2	32658928
Pubmed	Combination of polymorphisms in luteinizing hormone β, estrogen receptor β and progesterone receptor and susceptibility to infertility and endometriosis.	ESR2 LHB	2.35e-05	3	98	2	21764500
Pubmed	TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.	MEFV TNFRSF1B	4.70e-05	4	98	2	30457980
Pubmed	NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.	KDM6B NOTCH4	4.70e-05	4	98	2	37478314
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS19 SSPOP SEMA5B ADAMTSL2	6.18e-05	75	98	4	20637190
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KDM6B MAST2 PRAG1 ELAC2 C6orf132 PPP1R26 RADIL CELSR1 ZFYVE26 ADAT1 AHNAK2 BAHCC1	6.57e-05	1105	98	12	35748872
Pubmed	Pyramidal neuron subtype diversity governs microglia states in the neocortex.	RELN TCERG1L	7.82e-05	5	98	2	35948630
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	PHRF1 PPP1R26 FARP1 SPOCD1	7.95e-05	80	98	4	19389623
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	IL10RA ADAMTS19 NUDT7 GCH1 ZNF217 MAGI2 RADIL FARP1 RP1L1 NOTCH4	1.02e-04	814	98	10	23251661
Pubmed	Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene.	RELN MDGA1	1.17e-04	6	98	2	18384059
Pubmed	Juxtaposition of CNR protocadherins and reelin expression in the developing spinal cord.	RELN PCDHA8	1.17e-04	6	98	2	11312598
Pubmed	Expression patterns of group-I aristaless-related genes during craniofacial and limb development.	SHOX2 PRRX2	1.17e-04	6	98	2	11520673
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TET2 PLEKHG2 RAB11FIP1 MAST2 PRAG1 C6orf132 RADIL MAP7D1 SAMD11 AHNAK2	1.61e-04	861	98	10	36931259
Pubmed	Differential expression of mannose-6-phosphate receptor regulates T cell contraction.	GZMA TNFRSF1B	1.64e-04	7	98	2	25990242
Pubmed	Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia.	GCH1 PRKN	1.64e-04	7	98	2	19491146
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	TET2 PHRF1 SHOX2 ZNF217 C6orf132 MAP7D1	2.40e-04	307	98	6	37499664
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	IKZF4 RADIL ZNF469 MYO15B	2.45e-04	107	98	4	11347906
Pubmed	Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS).	ESR2 LHB	2.79e-04	9	98	2	18767927
Pubmed	Tumour necrosis factor gene polymorphism: a predictive factor for the development of post-transplant lymphoproliferative disease.	IL10RA TNFRSF1B	2.79e-04	9	98	2	19738620
Pubmed	Effect of polymorphisms in selected genes involved in pituitary-testicular function on reproductive hormones and phenotype in aging men.	ESR2 LHB	2.79e-04	9	98	2	20173016
Pubmed	Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.	CRACD CRACDL	3.48e-04	10	98	2	31234534
Pubmed	A forward genetic screen in mice identifies mutants with abnormal cortical patterning.	RELN LRP2	4.25e-04	11	98	2	23968836
Pubmed	Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.	CTSF CRACDL	4.25e-04	11	98	2	19416921
Pubmed	Synaptic vesicle trafficking and Parkinson's disease.	SYT11 PRKN	4.25e-04	11	98	2	21563316
Pubmed	Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve.	ESR2 LHB	5.09e-04	12	98	2	12801993
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	RELN PCDHA8	5.09e-04	12	98	2	10612399
Pubmed	A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.	TET2 CELSR1	6.01e-04	13	98	2	26989192
Pubmed	Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning.	CELSR1 PRKCZ	6.01e-04	13	98	2	27597235
Pubmed	Interaction of the type IIa Na/Pi cotransporter with PDZ proteins.	MAST2 RGS3	7.00e-04	14	98	2	11099500
Pubmed	Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.	IKZF4 NOTCH4	7.00e-04	14	98	2	21804548
Pubmed	KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.	TNFRSF1B NOTCH4	7.00e-04	14	98	2	25401743
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ADAMTS19 MAST2 ELAC2 MAGI2 CRACDL ALDH16A1 AMOTL1 HPF1 TMEM30A PRKCZ MYBPHL	7.55e-04	1242	98	11	30973865
Pubmed	Coordinated histone modifications mediated by a CtBP co-repressor complex.	ZNF217 ELAC2	8.06e-04	15	98	2	12700765
Pubmed	Lgl1 deficiency disrupts hippocampal development and impairs cognitive performance in mice.	RELN PRKCZ	9.19e-04	16	98	2	31415124
Pubmed	Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons.	RELN TMPO	1.04e-03	17	98	2	21976703
Pubmed	Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.	SHOX2 PRRX2	1.04e-03	17	98	2	22411303
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	RELN PCDHA8	1.17e-03	18	98	2	15570159
Pubmed	LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.	LRP2 PRKCZ	1.17e-03	18	98	2	32901292
Pubmed	MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.	RELN PRKCZ	1.30e-03	19	98	2	19666823
Pubmed	Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.	PHRF1 NOTCH4	1.59e-03	21	98	2	21408207
Pubmed	Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.	IL10RA LRP2	1.59e-03	21	98	2	9616220
Pubmed	Hereditary Dystonia Overview	CTSF GCH1 PRKN	1.64e-03	82	98	3	20301334
Pubmed	USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components.	CELSR1 PRKCZ	1.75e-03	22	98	2	35440748
Pubmed	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.	AMOTL1 PRKCZ	1.75e-03	22	98	2	27521426
Pubmed	The apical complex couples cell fate and cell survival to cerebral cortical development.	RELN PRKCZ	1.75e-03	22	98	2	20399730
Pubmed	Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.	RELN KDM6B	1.75e-03	22	98	2	25079229
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CARMIL3 PLEKHG2 RAB11FIP1	1.81e-03	85	98	3	15449545
Pubmed	Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.	RGS3 PRKN	1.91e-03	23	98	2	16637659
Pubmed	Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.	PPM1G LRP2	1.91e-03	23	98	2	20468071
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	RAB11FIP1 MAST2 PHKB	1.94e-03	87	98	3	17979178
Pubmed	Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.	TNFRSF1B NOTCH4	2.08e-03	24	98	2	11739537
Pubmed	The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis.	CELSR1 PRKCZ	2.08e-03	24	98	2	20223754
Pubmed	Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.	RELN MDGA1	2.08e-03	24	98	2	21821099
Pubmed	Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.	ESR2 LHB	2.26e-03	25	98	2	17507624
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CARMIL3 CCDC177 PPM1G PHKB SYT11 NPTXR	2.30e-03	475	98	6	31040226
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ZNF217 FARP1 AMOTL1 TMEM30A AHNAK2	2.53e-03	332	98	5	37433992
Pubmed	TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex.	PRKN TNFRSF1B	2.63e-03	27	98	2	31505254
GeneFamily	PDZ domain containing	MAST2 RGS3 MAGI2 RADIL AHNAK2	1.06e-04	152	56	5	1220
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PHRF1 PPP1R3G PPP1R26 FARP1 SPOCD1	2.40e-04	181	56	5	694
GeneFamily	Nudix hydrolase family	NUDT7 NUDT8	2.49e-03	24	56	2	667
CoexpressionAtlas	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0	CTSF PHRF1 SHMT1 GCH1 ZNF217 ZSCAN25 RAB11FIP1 KDM6B PRAG1 CRACD CELSR1 MOGS LY6G6D SEMA5B ALDH16A1 HPF1 PRKN PRKCZ ADAMTSL2 BAHCC1	8.66e-07	1275	96	20	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 ZSCAN25 RADIL SEMA5B MYBPHL TSPYL4	1.41e-06	157	99	6	f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell	ICU-SEP-Lymphocyte-T_NK-dnT\|ICU-SEP / Disease, Lineage and Cell Type	CTSF NUDT7 IKZF4 CRACDL MDGA1 BAHCC1	1.94e-06	166	99	6	96d92316cee20b722fe782db9dafcceb8f2c220b
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_3\|Classical_Monocyte / Disease condition and Cell class	NUDT7 SHMT1 ELAC2 SYT11 ADAT1 ENOX2	4.11e-06	189	99	6	8b6f92ccfffc743c07201bc971b3dc1a6fa14ccc
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_3\|COVID-19_Convalescent / Disease condition and Cell class	NUDT7 SHMT1 ELAC2 SYT11 ADAT1 ENOX2	4.11e-06	189	99	6	732e8dcffcb634ca2968f9170c9c4b31dd5d4206
ToppCell	Parenchyma_Control_(B.)-Immune-TX-MoAM-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	IL10RA TET2 GCH1 KDM6B MEFV TNFRSF1B	5.69e-06	200	99	6	59b2ebb69699c9bebf8c2697eb678fdccd0a998c
ToppCell	Lung_Parenchyma-Control-Myeloid-MoAM-MoAM-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IL10RA TET2 GCH1 KDM6B MEFV TNFRSF1B	5.69e-06	200	99	6	390f9429feae991b8524e2815d8fcd4914c74459
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-dn_T\|ICU-SEP / Disease, condition lineage and cell class	CTSF NUDT7 IKZF4 CRACDL C1orf52 MDGA1	5.69e-06	200	99	6	9ee3e18dc429b9c472e3e366d9bfdbb150daa369
ToppCell	Lung_Parenchyma-Control-Myeloid-MoAM-MoAM\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IL10RA TET2 GCH1 KDM6B MEFV TNFRSF1B	5.69e-06	200	99	6	f7e9b4a8ededb116774528b38ea3381b6f05915c
ToppCell	Lung_Parenchyma-Control-Myeloid-MoAM\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IL10RA TET2 GCH1 KDM6B MEFV TNFRSF1B	5.69e-06	200	99	6	d98c523ac0e4767aaeef50cae142513d115212ab
ToppCell	Healthy_Control-Myeloid-Macrophages-FCN1_high\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	GCH1 PPP1R3G SMTN CRACD NOTCH4	2.51e-05	155	99	5	cd2ccb4632713b4def3a1064599b78207e2e44c0
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PRAG1 NPTXR CRACDL MDGA1 ADAMTSL2	3.01e-05	161	99	5	e3327c296d48e821004e61a573abb75624a6f040
ToppCell	facs-Lung-nan-3m-Epithelial-type_I_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAB11FIP1 RADIL NPTXR PRKN PRKCZ	3.48e-05	166	99	5	11b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCell	facs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAB11FIP1 RADIL NPTXR PRKN PRKCZ	3.48e-05	166	99	5	fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMTN SEMA5B SYT11 SAMD11 PRRX2	4.85e-05	178	99	5	9fc5688cf705a74398d24e10e0aab4758612e72b
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TET2 PLEKHG2 SSPOP MEFV ZNF469	5.12e-05	180	99	5	66c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IL10RA PPP1R3G PRAG1 SYT11 TNFRSF1B	5.53e-05	183	99	5	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	Mild/Remission-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IL10RA RAB11FIP1 PRAG1 SYT11 TNFRSF1B	5.68e-05	184	99	5	3d4864605c812862cf8926e02370eea3b8ccf32f
ToppCell	10x5'-Lung-Myeloid_Monocytic-Nonclassical_monocytes\|Lung / Manually curated celltypes from each tissue	GCH1 MEFV TMPO TNFRSF1B NOTCH4	6.77e-05	191	99	5	a862a571625ab7238589ff201e5954f602c3bd7e
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RELN CHRDL2 RAB11FIP1 RADIL PRKCZ	6.94e-05	192	99	5	5e709c0714e8eba27e03a6def0544256bedb3ced
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESR2 NUDT8 CRACD ALPK3 MYBPHL	6.94e-05	192	99	5	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RELN CHRDL2 RAB11FIP1 RADIL PRKCZ	6.94e-05	192	99	5	5f4f44f15d3a2846981e68296643a4634930a211
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-NK-NK-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GCH1 MYO15B GZMA FDXACB1 NOTCH4	6.94e-05	192	99	5	6d7dd35869d86c3e991a61e17825053a3bfab44d
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESR2 NUDT8 CRACD ALPK3 MYBPHL	6.94e-05	192	99	5	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PRAG1 SMTN SEMA5B ADAMTSL2 PRRX2	7.11e-05	193	99	5	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IL10RA GCH1 KDM6B MEFV TNFRSF1B	7.29e-05	194	99	5	de9c7c602d886d0cd8bbd1d7e7744f84df951238
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IL10RA GCH1 KDM6B MEFV TNFRSF1B	7.29e-05	194	99	5	49441ca0a8fa34cb847fecbb4b809dd01d879ebb
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IL10RA GCH1 KDM6B MEFV TNFRSF1B	7.29e-05	194	99	5	16c6fcbd36d473b883fb5361caca86eb134767ab
ToppCell	356C-Myeloid-Monocyte-CD14+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TET2 GCH1 KDM6B MEFV TNFRSF1B	7.29e-05	194	99	5	3f9ac1de8605a7930f49a7ce0e32aea9997d7791
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PRAG1 SMTN SEMA5B ADAMTSL2 PRRX2	7.29e-05	194	99	5	67f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IL10RA GCH1 PLEKHG2 MEFV TNFRSF1B	7.29e-05	194	99	5	dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCell	356C-Myeloid-Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TET2 GCH1 KDM6B MEFV TNFRSF1B	7.29e-05	194	99	5	a41cde3088b43670210daab4f43a24aa83dbd45b
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	TET2 GCH1 MEFV HPS3 TNFRSF1B	7.47e-05	195	99	5	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SHMT1 ELAC2 PPP1R26 TBC1D12 NOTCH4	7.47e-05	195	99	5	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	TET2 GCH1 MEFV HPS3 TNFRSF1B	7.47e-05	195	99	5	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	mLN-T_cell-Treg\|T_cell / Region, Cell class and subclass	IL10RA RAB11FIP1 IKZF4 TNFRSF1B ENOX2	7.84e-05	197	99	5	3779489d57ebda33277c79cba037f4c73128c8ba
ToppCell	Mild/Remission-B_intermediate-6\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IL10RA RAB11FIP1 PRAG1 SYT11 TNFRSF1B	7.84e-05	197	99	5	5370dda4a25e3a53d6fe2c887b7dabd7a58462b4
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 GCH1 KDM6B MEFV TNFRSF1B	7.84e-05	197	99	5	0c059476a8cdc6ac71a01d9c414295177f45f8de
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 GCH1 KDM6B MEFV TNFRSF1B	8.03e-05	198	99	5	4b6767bd6fd4bd43eed18fd4a34c20923fa795da
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IL10RA RAB11FIP1 IKZF4 PPM1G TNFRSF1B	8.03e-05	198	99	5	03423d6c614440b9c738f75ac3f5a6941719a279
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 GCH1 KDM6B MEFV TNFRSF1B	8.03e-05	198	99	5	18daf83309813f914b17bd226ea8a9269a26b107
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 GCH1 KDM6B MEFV TNFRSF1B	8.03e-05	198	99	5	72c7474e084d1334a09c0a3b0f3c3137038794c8
ToppCell	Severe-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IL10RA TET2 RAB11FIP1 SYT11 TNFRSF1B	8.03e-05	198	99	5	8402421dc060926e968efe39a4e907f1e8ae5b1f
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 PLEKHG2 RAB11FIP1 KDM6B TBC1D12	8.03e-05	198	99	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL10RA BIRC7 ALPK3 TNFRSF1B SPOCD1	8.22e-05	199	99	5	98c0d57c247d39bc771d81f4387f8dd01222628e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RAB11FIP1 ELAC2 GCSAM ZNF469 MNAT1	8.22e-05	199	99	5	7271dbeca9aa838b88ad44d00059263a29c0316b
ToppCell	Severe-B_intermediate-6\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IL10RA TET2 RAB11FIP1 SYT11 TNFRSF1B	8.22e-05	199	99	5	bf6ebb63ab361d9d1946225894d7be433e9befab
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL10RA BIRC7 ALPK3 TNFRSF1B SPOCD1	8.22e-05	199	99	5	b818d46a39c8782188d82dc8931b8eec9d549dd1
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Monocytic-Monocyte_CD16\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IL10RA GCH1 MEFV TMPO TNFRSF1B	8.41e-05	200	99	5	83d9aa5b46ae7a71a258b2e44b3251f95bc9a1b7
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PLEKHG2 KDM6B ELAC2 SMTN AMOTL1	8.41e-05	200	99	5	410b1a31de21c57d87ca2104f61cf4a7d4dd2f30
ToppCell	Biopsy_IPF-Immune-Monocytes\|Biopsy_IPF / Sample group, Lineage and Cell type	IL10RA TET2 GCH1 MEFV TNFRSF1B	8.41e-05	200	99	5	80b2b7eecc5dce9d22f9c80562e4aea83bbf0f50
ToppCell	Sigmoid-(1)_T_cell-(18)_cycling_gd_T\|Sigmoid / shred on region, Cell_type, and subtype	IPPK ZSCAN25 SMTN SYT11 ZFYVE26	8.41e-05	200	99	5	6e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCell	Sigmoid-T_cell-cycling_gd_T\|Sigmoid / Region, Cell class and subclass	IPPK ZSCAN25 SMTN SYT11 ZFYVE26	8.41e-05	200	99	5	9769185abae084ffac36420c749625e679b70ca8
ToppCell	Biopsy_Other_PF-Immune-Monocytes\|Biopsy_Other_PF / Sample group, Lineage and Cell type	IL10RA TET2 GCH1 MEFV TNFRSF1B	8.41e-05	200	99	5	83bca55d48aae8885deb83e15b2684910e4c3358
ToppCell	COVID_non-vent-Lymphocytic-T_cell-Gamma_Delta_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	CTSF CHRDL2 SPATA31E1 GZMA	9.92e-05	108	99	4	04bfb90634b691020f246a8afbebd3bf944d1e0e
ToppCell	Thalamus\|World / BrainAtlas - Mouse McCarroll V32	ADAMTS19 SHOX2 AMOTL1 AHNAK2	1.31e-04	116	99	4	5ddfb2dd5459ff6d7ae38163a38eae64fda283b7
Disease	Schizophrenia	IL10RA RELN ESR2 SHMT1 GCH1 MAGI2 SYT11 LRP2 TNFRSF1B MDGA1 NOTCH4	1.41e-04	883	96	11	C0036341
Disease	folic acid measurement	IL10RA NUDT7 MAGI2	4.58e-04	46	96	3	EFO_0005111
Disease	Parkinsonism (is_implicated_in)	GCH1 TNFRSF1B	5.65e-04	11	96	2	DOID:0080855 (is_implicated_in)
Disease	MAJOR AFFECTIVE DISORDER 2	MAGI2 PRKCZ	1.38e-03	17	96	2	C1839839
Disease	cortical surface area measurement	TET2 ADAMTS19 RELN CHRDL2 MAST2 KIAA1614 ELAC2 ZNF469 CELSR1 RP1L1 PRKCZ MNAT1	1.39e-03	1345	96	12	EFO_0010736
Disease	peritonsillar abscess	TET2 PRAG1	1.55e-03	18	96	2	EFO_0007429
Disease	Colorectal Carcinoma	TET2 TCERG1L ESR2 ZNF217 HPS3 SMTN LRP2 PRKCZ	2.08e-03	702	96	8	C0009402
Disease	phosphatidylcholine measurement	ESR2 PPM1G MYO15B NOTCH4 PRRX2	2.39e-03	284	96	5	EFO_0010226
Disease	pre-eclampsia (is_implicated_in)	ESR2 TNFRSF1B	2.99e-03	25	96	2	DOID:10591 (is_implicated_in)
Disease	blood chromium measurement	TCERG1L ELAC2	3.24e-03	26	96	2	EFO_0007579

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDKDPRGPSSGSCID	SYT11	106	Q9BT88
DAGACSGRNPKLLPV	TBC1D12	6	O60347
RPEPSTKSGGGRCAI	CEP295NL	226	Q96MC4
SSKGPGQSERPDCAR	BAHCC1	671	Q9P281
CKVERGPPGTRLENA	CXorf65	76	A6NEN9
GLRDPSVPTGGCKES	ALDH16A1	456	Q8IZ83
RVLGPGGCNTKAARP	COQ3	16	Q9NZJ6
TSFGLENKCGDPRGP	GZMA	226	P12544
SKPRCPGRARPGEGQ	ALPK3	136	Q96L96
AGDGPTQERCGPRSL	BIRC7	21	Q96CA5
LRRGTCEPAVKGSPS	AMOTL1	6	Q8IY63
PCKAERPRESLGGTE	GCSAM	111	Q8N6F7
CAITVKSPGREPGRD	CELSR1	2976	Q9NYQ6
RRTPDPAKSAGGCRN	C1orf52	36	Q8N6N3
GGCRNKAEKRLPGPD	C1orf52	46	Q8N6N3
RCPPQGTKGKGEDST	RAD54L2	656	Q9Y4B4
QAKRADSPGRLVPCG	ADAT1	381	Q9BUB4
PGPDGGVLRRASCKS	RGS3	381	P49796
PGLDSEARDCNGPRK	ADAMTS19	661	Q8TE59
GKNTPERSGLPKGCL	IPPK	306	Q9H8X2
TCSGAEGLARPKQPL	NUDT8	206	Q8WV74
GKRRPGGEGPQCEKT	HPF1	6	Q9NWY4
DGECPSPGRGSAAKR	PRRX2	86	Q99811
ESGGPCGKALPERQR	RADIL	921	Q96JH8
GSPAELQCEVRGKPR	MDGA1	456	Q8NFP4
LPTEGGCRAGKPTLV	PCDHA8	726	Q9Y5H6
RGAGNCPECGTPLRK	MNAT1	41	P51948
KVLCGGEPCPENGRS	MAGI2	861	Q86UL8
NRCASPVTGPGSKRD	ESR2	131	Q92731
GREKSGIQPLCPERS	TMPO	331	P42166
GPCRRSTSDCGGPKD	LHB	111	P01229
RERPPGCKTVFVGGL	ENOX2	121	Q16206
EGLSPGGKRRRGCNS	KDM6B	221	O15054
PQCRRGKAGRAGTPS	KIAA1614	116	Q5VZ46
GCLIRRGNADTPEGP	CARMIL3	121	Q8ND23
GEEGFKGCLQPRALP	PHRF1	551	Q9P1Y6
NGKPQTRSGPECGLA	ADAMTSL2	826	Q86TH1
ESPLTDGLGPKFGRC	IL10RA	466	Q13651
DRPGKRCAAEGSSPL	LRP2	4041	P98164
RSPGPCRALEGGQAE	MEFV	186	O15553
SEKLRRAPGEVCFPG	NUDT7	61	P0C024
CSSDAGRKRGPGTPA	CHRDL2	201	Q6WN34
GKLGRCESGLPRGLQ	NPTXR	156	O95502
EKCPLGTAPALRGTR	CRACDL	726	Q6NV74
RLGCGKGVPDPRSQP	RELN	2231	P78509
PKLRHTCEQGDGVGP	MOGS	131	Q13724
SGGLNGRPEKLPDVC	RABGGTB	226	P53611
PEKPQRDLGSEGGCL	MYO15B	936	Q96JP2
KGNCPLGRRSLPGVS	DLST	21	P36957
PKPRLEGGRICENGA	C6orf132	591	Q5T0Z8
PEGKPSSGRDCRRGG	BORCS6	116	Q96GS4
AESPGGQSCRRGKEP	FARP1	401	Q9Y4F1
GRCDSRGNQRKTPPV	CRACD	701	Q6ZU35
RKDCGPVDTKVPGAG	CTSF	121	Q9UBX1
PCAPGGTAKTRRPDN	TMEM30A	16	Q9NV96
CSLEIRKPGPFDGGI	MYBPHL	316	A2RUH7
TLPRNGRDQGRGCDP	MAP7D1	316	Q3KQU3
GCPLTQKSEPSLRRG	MAST2	1761	Q6P0Q8
PRKAEVPCAAAEGGR	CCDC177	51	Q9NQR7
CRGQGGTPADKPQRE	FDXACB1	126	Q9BRP7
GHCPGGQRASRSPKE	C4orf54	216	D6RIA3
GKDNLERDPSGGCVP	IKZF4	26	Q9H2S9
GRPDRPIGCLGTSKI	PHKB	551	Q93100
KNTCPGDRSALRPSG	SHMT1	386	P34896
KEAVTTCGEGRPQPG	LY6G6D	36	O95868
PCPERGKGPSGEADR	RAB11FIP1	1006	Q6WKZ4
RCPKGSLEQDGGCVP	SSPOP	4101	A2VEC9
GCGAGLLPEPDQRKV	PRKN	336	O60260
VPCKLEPDRFCGGGR	HPS3	16	Q969F9
DTCRKANAIPDGPRG	YARS2	411	Q9Y2Z4
EKPRGARCSNGFPER	GCH1	11	P30793
VKCSGDGVGAPRLPL	PPM1G	11	O15355
SGPLRGAKEPTGCTE	SHOX2	31	O60902
SGPTCGRRPGLKQED	SAMD11	61	Q96NU1
GSFKPERVGVCALPG	CCT8L2	196	Q96SF2
GCLGSKLGPDPSRDQ	SPATA31E1	706	Q6ZUB1
QPSRAAGGGSRCKPE	PPP1R26	161	Q5T8A7
LGTGGPARPEVLCRK	PPP1R26	866	Q5T8A7
AEVKGSGRVLSCPGP	PPP1R3G	231	B7ZBB8
GFQGPRCEGKLRPSC	NOTCH4	796	Q99466
DPRLCEGTPQEGGLR	AHNAK2	401	Q8IVF2
TKRNRTEGCGSPKPE	TCERG1L	416	Q5VWI1
RTREKRGPSGCSGGP	ELAC2	41	Q9BQ52
RPQGCPGKARAETSQ	RP1L1	551	Q8IWN7
KKGPVPCAQDRGTDR	SPOCD1	426	Q6ZMY3
PQDCRVSPGGGSKEK	ZSCAN25	261	Q6NSZ9
EPRGPAGQKALEACG	TSPYL4	121	Q9UJ04
SRRGAPGTANCELKP	TRABD2A	21	Q86V40
DPVGGGNLTNKRPSC	RFPL2	51	O75678
RKRTCTNPEPRNGGL	SEMA5B	876	Q9P283
QGKCSGPAEQEKRGP	PRAG1	291	Q86YV5
AREGGPKCADRPSVA	ZNF469	1156	Q96JG9
LCAGETGAQKPPGDR	ZNF469	2686	Q96JG9
SRRTGCPPALLGKDV	ZNF217	751	O75362
SKPSPSLGCGRRGEV	PLEKHG2	11	Q9H7P9
RKCRPGFGVARPGTE	TNFRSF1B	141	P20333
SSQPPGDRRKGLLGC	nan	26	Q5VSD8
PECRLGLKEGRPFSG	TET2	1356	Q6N021
EKGGGPPRCSITELL	ZFYVE26	1051	Q68DK2
RELPARKCSVPGLGE	PNMA8C	141	A0A1B0GUJ8
RKCSVPGLGEKPEAG	PNMA8C	146	A0A1B0GUJ8
QLRSCPQEEGPRGRG	SMTN	406	P53814
PGKFGIIRPGCALES	YRDC	246	Q86U90
DPKERLGCRPQTGFS	PRKCZ	496	Q05513