Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	LRR_6	FBXL17 NLRP12 NLRC3	1.75e-04	55	37	3	PF13516
Domain	PP2C_BS	PPM1F ILKAP	2.49e-04	12	37	2	IPR000222
Domain	PP2C_SIG	PPM1F ILKAP	3.42e-04	14	37	2	SM00331
Domain	PPM_1	PPM1F ILKAP	3.95e-04	15	37	2	PS01032
Domain	PP2C	PPM1F ILKAP	5.10e-04	17	37	2	IPR015655
Domain	PP2C	PPM1F ILKAP	6.39e-04	19	37	2	PF00481
Domain	PP2Cc	PPM1F ILKAP	7.09e-04	20	37	2	SM00332
Domain	-	PPM1F ILKAP	7.09e-04	20	37	2	3.60.40.10
Domain	PPM_2	PPM1F ILKAP	7.09e-04	20	37	2	PS51746
Domain	PPM-type_phosphatase_dom	PPM1F ILKAP	7.09e-04	20	37	2	IPR001932
Domain	AA-permease/SLC12A_dom	SLC7A4 SLC12A9	8.60e-04	22	37	2	IPR004841
Domain	AA_permease	SLC7A4 SLC12A9	8.60e-04	22	37	2	PF00324
Domain	NACHT	NLRP12 NLRC3	9.41e-04	23	37	2	PS50837
Domain	NACHT_NTPase	NLRP12 NLRC3	9.41e-04	23	37	2	IPR007111
Domain	TPR-like_helical_dom	WDR35 ATR TTC16 CNOT10	1.13e-03	233	37	4	IPR011990
Domain	Leu-rich_rpt	FBXL17 NLRP12 LRFN1 NLRC3	1.96e-03	271	37	4	IPR001611
Domain	F-box-like	FBXL17 FBXW11	3.43e-03	44	37	2	PF12937
Domain	-	FBXL17 NLRP12 LRFN1 NLRC3	3.62e-03	321	37	4	3.80.10.10
Domain	L_dom-like	FBXL17 NLRP12 LRFN1 NLRC3	3.91e-03	328	37	4	IPR032675
Domain	HEAT	TNPO1 ATR	4.07e-03	48	37	2	PF02985
Domain	FBOX	FBXL17 FBXW11	4.76e-03	52	37	2	SM00256
Domain	HEAT	TNPO1 ATR	5.89e-03	58	37	2	IPR000357
Domain	F-box	FBXL17 FBXW11	7.79e-03	67	37	2	PF00646
Domain	-	ATR TTC16 CNOT10	7.90e-03	207	37	3	1.25.40.10
Domain	HEAT_REPEAT	TNPO1 ATR	8.47e-03	70	37	2	PS50077
Domain	FBOX	FBXL17 FBXW11	8.95e-03	72	37	2	PS50181
Domain	-	TNPO1 ATR MROH6	9.56e-03	222	37	3	1.25.10.10
Domain	F-box_dom	FBXL17 FBXW11	9.68e-03	75	37	2	IPR001810
Domain	TPR_1	TTC16 CNOT10	1.37e-02	90	37	2	PF00515
Domain	TPR_1	TTC16 CNOT10	1.37e-02	90	37	2	IPR001440
Pubmed	Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes.	MYC SLC7A4	1.16e-06	2	38	2	18460403
Pubmed	YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process.	MYC YWHAE	3.48e-06	3	38	2	27863420
Pubmed	Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.	MYC ATR	3.48e-06	3	38	2	31266951
Pubmed	Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure.	NLRP12 NLRC3	3.48e-06	3	38	2	26763980
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TMPO TNS2 YWHAE PPM1F SBF2 FBXW11 CCDC138 ILKAP	1.46e-05	1049	38	8	27880917
Pubmed	Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse.	MYC YWHAE	3.24e-05	8	38	2	12905154
Pubmed	Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation.	MYC YWHAE	3.24e-05	8	38	2	11208609
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	TNPO1 TNS2 ATR YWHAE CNOT10 ABTB2 FBXW11	5.89e-05	931	38	7	27432908
Pubmed	S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer.	MYC FBXW11	9.00e-05	13	38	2	29507620
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	YWHAE CNOT10 FBXW11 CCDC138	1.08e-04	226	38	4	25900982
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	MTCL1 ZFP36L2 YWHAE CNOT10 CCDC138	1.20e-04	446	38	5	24255178
Pubmed	FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).	TMPO ATR	1.21e-04	15	38	2	27365398
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRFN1 MROH6 ZFP36L2 KIF26A ABTB2 SBF2 MYOM3	1.71e-04	1105	38	7	35748872
Pubmed	Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase.	YWHAE FBXW11	1.76e-04	18	38	2	30240640
Pubmed	FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.	MYC FBXW11	2.18e-04	20	38	2	32350066
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	DECR1 TNPO1 TMPO YWHAE NLRC3 FBXW11	2.27e-04	809	38	6	32129710
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	TNS2 MTCL1 YWHAE FBXW11 ILKAP	3.82e-04	573	38	5	28330616
Pubmed	Functional specialization of beta-arrestin interactions revealed by proteomic analysis.	TMPO ATR KIF26A YWHAE	3.91e-04	317	38	4	17620599
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	TNPO1 ATR	4.01e-04	27	38	2	23027611
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TNPO1 TMPO MTCL1 ATR YWHAE	4.10e-04	582	38	5	20467437
Pubmed	Vpr and its interactions with cellular proteins.	ATR YWHAE	4.32e-04	28	38	2	20012529
Pubmed	Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection.	MTCL1 YWHAE	5.65e-04	32	38	2	14613977
Pubmed	Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling.	TMPO ILKAP	7.56e-04	37	38	2	36835656
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	TNPO1 TNS2 SLC12A9 YWHAE PPM1F ABTB2	7.80e-04	1021	38	6	26760575
Pubmed	Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.	DECR1 TMPO YWHAE	8.54e-04	170	38	3	36470425
GeneFamily	Protein phosphatases, Mg2+/Mn2+ dependent	PPM1F ILKAP	3.10e-04	17	28	2	701
GeneFamily	NLR family	NLRP12 NLRC3	6.79e-04	25	28	2	666
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC16 CNOT10	1.36e-02	115	28	2	769
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP TTC16 SHISA3 MYOM3	1.01e-05	159	38	4	c9e093d7c1dca83f6546adaf3d874929e2cea612
ToppCell	CV-Mild-7\|CV / Virus stimulation, Condition and Cluster	TNPO1 ABTB2 FBXW11 CCDC138	1.31e-05	170	38	4	25ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	TNPO1 ABTB2 FBXW11 CCDC138	1.41e-05	173	38	4	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	TNPO1 MIGA1 ATR SBF2	2.16e-05	193	38	4	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	WDR35 SLC12A9 DYNLT4 TTC16	2.39e-05	198	38	4	6d90b541fde357fbb40f8f7d4e8628a48b679718
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	MYC TNS2 SLC12A9 ZFP36L2 PPM1F	1.62e-05	192	38	5	5222_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	MYC MTCL1 SLC12A9 ZFP36L2 PPM1F	1.66e-05	193	38	5	5215_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	TNS2 B4GALNT1 MTCL1 ZFP36L2 PPM1F	1.79e-05	196	38	5	3416_DN
Drug	4-hydroxyundec-2-enal	MYC DECR1	4.05e-05	6	38	2	CID000093127
Drug	AC1L9MLU	DECR1 NLRP12	4.05e-05	6	38	2	CID000422628
Drug	AC1L9K36	DECR1 TNPO1 TMPO	4.38e-05	41	38	3	CID000446779
Drug	norperazine	DECR1 INMT	5.67e-05	7	38	2	CID000151090
Drug	5,5-dimethyl-1-pyrroline-N-oxide	DECR1 TMPO NLRP12	7.04e-05	48	38	3	CID000001774
Drug	N-hydroxyamphetamine	DECR1 NLRP12	1.77e-04	12	38	2	CID000065546
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	MYC TMPO TNS2 ZFP36L2	2.03e-04	175	38	4	6891_DN
Drug	Adiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; MCF7; HT_HG-U133A	TNPO1 TMPO B4GALNT1 ZFP36L2	2.41e-04	183	38	4	1709_DN
Drug	oxythiamine	DECR1 TMPO	2.44e-04	14	38	2	CID000008681
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	MYC MTCL1 ZFP36L2 PPM1F	2.56e-04	186	38	4	916_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	MYC TMPO ZFP36L2 PPM1F	2.72e-04	189	38	4	5203_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	MYC TRMT13 MTCL1 ZFP36L2	2.72e-04	189	38	4	1005_DN
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A	MYC MTCL1 SLC12A9 ZFP36L2	2.83e-04	191	38	4	5210_DN
Drug	Rescinnamin [24815-24-5]; Down 200; 6.4uM; MCF7; HT_HG-U133A	TMPO TNS2 TRMT13 ZFP36L2	2.89e-04	192	38	4	2785_DN
Drug	geldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A	MYC ZFP36L2 FRMD1 PPM1F	2.95e-04	193	38	4	5588_DN
Drug	5213008; Down 200; 18uM; MCF7; HT_HG-U133A_EA	TNS2 TRMT13 ZFP36L2 PPM1F	3.07e-04	195	38	4	898_DN
Drug	Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; PC3; HT_HG-U133A	TNS2 B4GALNT1 ATR FBXW11	3.13e-04	196	38	4	5881_DN
Drug	pioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A	B4GALNT1 MTCL1 ZFP36L2 FBXW11	3.13e-04	196	38	4	6898_DN
Drug	Triflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A	TRMT13 SLC12A9 ZFP36L2 PPM1F	3.13e-04	196	38	4	1691_DN
Drug	TMPone	DECR1 NLRP12	3.21e-04	16	38	2	CID000013220
Drug	furacin	DECR1 NLRP12	3.21e-04	16	38	2	CID000001839
Drug	2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A	TMPO B4GALNT1 ZFP36L2 PPM1F	3.25e-04	198	38	4	5219_DN
Drug	LY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	B4GALNT1 SLC12A9 ZFP36L2 FBXW11	3.25e-04	198	38	4	996_UP
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A	TMPO TRMT13 FRMD1 PPM1F	3.25e-04	198	38	4	7500_DN
Drug	NSC28026	DECR1 NLRP12	4.08e-04	18	38	2	CID000000848
Drug	2,4-decadienal	MYC YWHAE	5.58e-04	21	38	2	ctd:C057349
Drug	DAF-2DA	DECR1 NLRP12	6.71e-04	23	38	2	CID006603693
Drug	dihydroflavonol	MYC DECR1	6.71e-04	23	38	2	CID000147806
Drug	DMPO-OH	DECR1 TMPO	6.71e-04	23	38	2	CID003035043
Drug	2-methyl-2-nitrosopropane	DECR1 TMPO	7.94e-04	25	38	2	CID000023272
Drug	nitrofuran	DECR1 NLRP12	7.94e-04	25	38	2	CID000011865
Drug	hematoporphyrin	DECR1 NLRP12	9.27e-04	27	38	2	CID000011103
Drug	N-nitrosodibutylamine	DECR1 INMT	9.98e-04	28	38	2	CID000013542
Drug	ketopantoate	DECR1 NLRP12	1.07e-03	29	38	2	CID000000038
Drug	DABCO	DECR1 NLRP12	1.07e-03	29	38	2	CID000009237
Drug	GW0742	MYC YWHAE	1.22e-03	31	38	2	ctd:C479979
Drug	acetophenone	DECR1 INMT	1.30e-03	32	38	2	CID000007410
Drug	Pivanex	MYC DECR1	1.47e-03	34	38	2	CID000060748
Drug	LY134046	MYC TMPO	1.47e-03	34	38	2	CID000121938
Drug	(nacn)2	DECR1 TMPO	1.56e-03	35	38	2	CID006327569
Disease	lateral orbital frontal cortex volume measurement	FBXL17 MTCL1	3.93e-04	24	36	2	EFO_0010312

Protein segments in the cluster

Peptide	Gene	Start	Entry
ACRLAKAAFDDAIAE	YWHAE	191	P62258
ACASLGLLYASTRDA	B4GALNT1	16	Q00973
ASLLAALCYAEFGAR	SLC7A4	81	O43246
CSASENLYLDALSLD	MTCL1	1336	Q9Y4B5
DLALCRAYEAAASAL	TMPO	566	P42166
RAALAYLLQVSDACA	NLRC3	601	Q7RTR2
CSLDAYRAALCNLAS	INMT	171	O95050
DCSSLEEYNIAAALL	SBF2	621	Q86WG5
ALEAALAAGLHDACY	DYNLT4	126	Q5JR98
NDLAAGRAYDLCVLA	LRFN1	481	Q9P244
LSYLDARSLCAAELV	FBXW11	136	Q9UKB1
YLAALERATAALEQC	KIF26A	1836	Q9ULI4
DLALYTAACLEEAGF	MROH6	111	A6NGR9
FLANLSLLDACYSSA	OR5C1	66	Q8NGR4
LLFEARCAAVAAAAA	ITPKA	36	P23677
ELANLAAFLCSDYAS	DECR1	276	Q16698
AHREEAYFLLAACAL	FRMD1	176	Q8N878
SLGLLRDATACYDRA	ATR	1711	Q13535
ADYLAQAFDSLCLDL	CCDC138	506	Q96M89
DRDILCKALASYVAA	FCGBP	3116	Q9Y6R7
ARRYAALAAEDCAAA	FBXL17	101	Q9UF56
ALAAEDCAAAARRFL	FBXL17	106	Q9UF56
DCAAAARRFLLSSAA	FBXL17	111	Q9UF56
KSAADARYEAACNRL	ILKAP	356	Q9H0C8
RALTGSEDYLLLACD	PPM1F	346	P49593
AYLEADALRHTSSCL	MIGA1	601	Q8NAN2
ATDLALRCLVETYAA	TRMT13	271	Q9NUP7
LYLQDLSAAASECID	MYC	176	P01106
ALRYCCAAADARLEQ	SHISA3	61	A0PJX4
AESCALAAVKALSLY	ABTB2	171	Q8N961
LACSAYVALALGDNL	CNOT10	536	Q9H9A5
FRAFEAARDLDACAL	ZSWIM9	391	Q86XI8
LVAYAAVDLSCLSLE	SLC12A9	426	Q9BXP2
CSAAALDVLANVYRD	TNPO1	386	Q92973
RAEAYLQLCDFSSAA	TTC16	101	Q8NEE8
EIYSLLALCACASRA	WDR35	1066	Q9P2L0
CCASAAAAAAAALLY	ZFP36L2	321	P47974
AADLLRQGAACSVLY	TNS2	1266	Q63HR2
VLLDAYSEHLAAALC	NLRP12	696	P59046
SAADYALAAALALTA	MYOM3	61	Q5VTT5