Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	N,N-dimethylaniline monooxygenase activity	FMO1 FMO6P	2.85e-04	6	88	2	GO:0004499
GeneOntologyMolecularFunction	transcription coactivator activity	KMT2C PARK7 FIZ1 NCOA4 PRDM16 EP300 ZXDB	3.84e-04	303	88	7	GO:0003713
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	VPS9D1 PLEKHG1 ACAP1 RASAL3 RASA2 HPS4 LARS1 C9orf72 ACAP2	3.94e-04	507	88	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	VPS9D1 PLEKHG1 ACAP1 RASAL3 RASA2 HPS4 LARS1 C9orf72 ACAP2	3.94e-04	507	88	9	GO:0030695
GeneOntologyBiologicalProcess	regulation of transforming growth factor beta receptor signaling pathway	FBN2 LRP1 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	1.27e-06	192	85	8	GO:0017015
GeneOntologyBiologicalProcess	regulation of cellular response to transforming growth factor beta stimulus	FBN2 LRP1 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	1.43e-06	195	85	8	GO:1903844
GeneOntologyBiologicalProcess	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	FBN2 ZNF423 LRP1 LRP2 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	1.63e-06	347	85	10	GO:0090092
GeneOntologyBiologicalProcess	regulation of cellular response to growth factor stimulus	FBN2 ZNF423 LRP1 LRP2 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	7.47e-06	412	85	10	GO:0090287
GeneOntologyBiologicalProcess	cellular response to transforming growth factor beta stimulus	COL4A2 FBN2 LRP1 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	1.01e-05	336	85	9	GO:0071560
GeneOntologyBiologicalProcess	response to transforming growth factor beta	COL4A2 FBN2 LRP1 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	1.19e-05	343	85	9	GO:0071559
GeneOntologyBiologicalProcess	response to growth factor	COL4A2 FBN2 EPHA2 ZNF423 LRP1 LRP2 ACAP2 PRDM16 CDH3 EP300 MEIS2 ADAMTSL2 AXIN1 HDAC1	1.40e-05	883	85	14	GO:0070848
GeneOntologyBiologicalProcess	transforming growth factor beta receptor superfamily signaling pathway	FBN2 ZNF423 LRP1 LRP2 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	1.46e-05	445	85	10	GO:0141091
GeneOntologyBiologicalProcess	transforming growth factor beta receptor signaling pathway	FBN2 LRP1 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	1.83e-05	276	85	8	GO:0007179
GeneOntologyBiologicalProcess	cellular response to L-leucine	UBR1 LARS1 EP300	1.87e-05	13	85	3	GO:0071233
GeneOntologyBiologicalProcess	negative regulation of transforming growth factor beta receptor signaling pathway	FBN2 LRP1 PRDM16 CDH3 ADAMTSL2 HDAC1	2.28e-05	138	85	6	GO:0030512
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	GHR COL4A2 FBN2 EPHA2 ZNF423 ROR1 LRP1 LRP2 IDE PRDM16 CDH3 EP300 SVEP1 ADAMTSL2 AXIN1 HDAC1	2.37e-05	1186	85	16	GO:0007167
GeneOntologyBiologicalProcess	cell surface receptor protein serine/threonine kinase signaling pathway	FBN2 ZNF423 LRP1 LRP2 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	2.89e-05	482	85	10	GO:0007178
GeneOntologyBiologicalProcess	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	FBN2 LRP1 LRP2 PRDM16 CDH3 ADAMTSL2 HDAC1	3.28e-05	218	85	7	GO:0090101
GeneOntologyBiologicalProcess	response to L-leucine	UBR1 LARS1 EP300	3.64e-05	16	85	3	GO:0043201
GeneOntologyBiologicalProcess	axial mesoderm formation	EPHA2 AXIN1	5.02e-05	3	85	2	GO:0048320
GeneOntologyBiologicalProcess	animal organ morphogenesis	GHR STIM1 PAPPA2 FBN2 FMN1 ATP8A2 EPHA2 SCN5A LRP2 MEIS3 ADAMTS5 TMEM215 EP300 MEIS2 AXIN1 HDAC1	5.35e-05	1269	85	16	GO:0009887
GeneOntologyBiologicalProcess	regulation of hydrogen peroxide-mediated programmed cell death	TRAP1 PARK7 EP300	6.24e-05	19	85	3	GO:1901298
GeneOntologyBiologicalProcess	regulation of cellular respiration	TRAP1 PARK7 IDE PRDM16	9.62e-05	58	85	4	GO:0043457
GeneOntologyBiologicalProcess	hydrogen peroxide-mediated programmed cell death	TRAP1 PARK7 EP300	9.83e-05	22	85	3	GO:0010421
GeneOntologyBiologicalProcess	programmed cell death in response to reactive oxygen species	TRAP1 PARK7 EP300	1.28e-04	24	85	3	GO:0097468
GeneOntologyBiologicalProcess	transcytosis	LRP1 LRP2 GP2	1.28e-04	24	85	3	GO:0045056
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LRP1 LRP2	1.66e-04	5	85	2	GO:1905167
GeneOntologyBiologicalProcess	chemoattraction of axon	LRP1 LRP2	1.66e-04	5	85	2	GO:0061642
GeneOntologyBiologicalProcess	axial mesoderm morphogenesis	EPHA2 AXIN1	1.66e-04	5	85	2	GO:0048319
GeneOntologyBiologicalProcess	cellular response to growth factor stimulus	COL4A2 FBN2 ZNF423 LRP1 LRP2 ACAP2 PRDM16 CDH3 EP300 ADAMTSL2 AXIN1 HDAC1	1.84e-04	850	85	12	GO:0071363
GeneOntologyBiologicalProcess	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	TRAP1 PARK7	2.49e-04	6	85	2	GO:1903751
GeneOntologyBiologicalProcess	regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	TRAP1 PARK7	2.49e-04	6	85	2	GO:1903750
GeneOntologyBiologicalProcess	regulation of androgen receptor signaling pathway	PARK7 EP300 HDAC1	2.79e-04	31	85	3	GO:0060765
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process in the vacuole	LRP1 LRP2	3.48e-04	7	85	2	GO:1904352
GeneOntologyBiologicalProcess	amyloid-beta clearance by cellular catabolic process	LRP1 IDE	4.62e-04	8	85	2	GO:0150094
GeneOntologyBiologicalProcess	negative regulation of complement activation, classical pathway	CR1 SVEP1	4.62e-04	8	85	2	GO:0045959
GeneOntologyBiologicalProcess	response to auditory stimulus	ATP8A2 KCNQ2 XPA	4.74e-04	37	85	3	GO:0010996
GeneOntologyBiologicalProcess	intrinsic apoptotic signaling pathway in response to hydrogen peroxide	TRAP1 PARK7	5.93e-04	9	85	2	GO:0036481
GeneOntologyBiologicalProcess	taurine metabolic process	GHR FMO1	5.93e-04	9	85	2	GO:0019530
GeneOntologyBiologicalProcess	alkanesulfonate metabolic process	GHR FMO1	5.93e-04	9	85	2	GO:0019694
GeneOntologyBiologicalProcess	amyloid-beta clearance	LRP1 LRP2 IDE	5.98e-04	40	85	3	GO:0097242
GeneOntologyBiologicalProcess	regulation of generation of precursor metabolites and energy	TRAP1 PARK7 IDE PRDM16 EP300	6.73e-04	169	85	5	GO:0043467
GeneOntologyBiologicalProcess	positive regulation of molecular function	GHR STIM1 EPHA2 PARK7 ROR1 LARS1 LRP1 IDE C9orf72 CR1 ST18 CDH3 EP300 AXIN1 HDAC1	6.86e-04	1430	85	15	GO:0044093
GeneOntologyBiologicalProcess	positive regulation of protein localization	STIM1 MALRD1 EPHA2 PARK7 HPS4 LRP1 LRP2 RFX6 EP300	7.28e-04	591	85	9	GO:1903829
GeneOntologyBiologicalProcess	regulation of complement activation, classical pathway	CR1 SVEP1	7.39e-04	10	85	2	GO:0030450
MousePheno	decreased respiration	STIM1 DPH1 CELSR3 LRP2 C9orf72 PRDM16 EP300 ADAMTSL2	2.78e-06	170	73	8	MP:0014274
MousePheno	additional anastomosis between intracranial vertebral arteries	COL4A2 TRIM45 ADCY9	1.12e-05	9	73	3	MP:0014003
MousePheno	respiratory failure	STIM1 DPH1 CELSR3 LRP2 C9orf72 PRDM16 EP300	2.38e-05	165	73	7	MP:0001953
MousePheno	limbs/digits/tail phenotype	GHR STIM1 PAPPA2 COL4A2 DPH1 FBN2 NALF1 RASAL3 FMN1 EPHA2 LRP1 LRP2 ADAMTS5 CMYA5 HPS5 SVEP1 ADAMTSL2 AXIN1	6.05e-05	1258	73	18	MP:0005371
MousePheno	prenatal growth retardation	GHR STIM1 DPH1 ZFAT FAF2 AKAP17A ENPP2 LRP1 XPA CR1 EP300 MEIS2 AXIN1 HDAC1	1.37e-04	869	73	14	MP:0010865
MousePheno	abnormal head morphology	COL4A2 DPH1 ZFAT AKAP17A ZNF423 PARK7 HPS4 LRP2 KCNQ2 MEIS3 IDE HPS5 PRDM16 EP300 AXIN1 HDAC1	1.73e-04	1120	73	16	MP:0000432
MousePheno	abnormal craniofacial morphology	PAPPA2 COL4A2 DPH1 ZFAT FBN2 FAF2 ZNF423 HPS4 LRP1 LRP2 MEIS3 IDE HPS5 PRDM16 EP300 ADCY9 ADAMTSL2 AXIN1	1.84e-04	1372	73	18	MP:0000428
MousePheno	craniofacial phenotype	PAPPA2 COL4A2 DPH1 ZFAT FBN2 FAF2 ZNF423 HPS4 LRP1 LRP2 MEIS3 IDE HPS5 PRDM16 EP300 ADCY9 ADAMTSL2 AXIN1	1.84e-04	1372	73	18	MP:0005382
MousePheno	kinked neural tube	AKAP17A ENPP2 EP300 AXIN1	2.19e-04	57	73	4	MP:0003400
MousePheno	abnormal limb morphology	GHR STIM1 PAPPA2 COL4A2 DPH1 FBN2 NALF1 RASAL3 FMN1 LRP1 ADAMTS5 CMYA5 SVEP1 ADAMTSL2 AXIN1	2.29e-04	1028	73	15	MP:0002109
MousePheno	abnormal tail morphology	PAPPA2 COL4A2 FBN2 EPHA2 LRP2 HPS5 SVEP1 ADAMTSL2 AXIN1	2.39e-04	403	73	9	MP:0002111
Domain	EGF-like_CS	FBN2 MALRD1 CELSR3 EPHA2 LRP1 LRP2 MATN4 SVEP1 GP2	2.89e-06	261	85	9	IPR013032
Domain	EGF_2	FBN2 MALRD1 CELSR3 EPHA2 LRP1 LRP2 MATN4 SVEP1 GP2	3.27e-06	265	85	9	PS01186
Domain	cEGF	FBN2 LRP1 LRP2 MATN4	5.53e-06	26	85	4	IPR026823
Domain	cEGF	FBN2 LRP1 LRP2 MATN4	5.53e-06	26	85	4	PF12662
Domain	ASX_HYDROXYL	FBN2 CELSR3 LRP1 LRP2 MATN4 SVEP1	6.29e-06	100	85	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBN2 CELSR3 LRP1 LRP2 MATN4 SVEP1	8.81e-06	106	85	6	IPR000152
Domain	EGF_3	FBN2 MALRD1 CELSR3 LRP1 LRP2 MATN4 SVEP1 GP2	1.17e-05	235	85	8	PS50026
Domain	EGF-like_dom	FBN2 MALRD1 CELSR3 LRP1 LRP2 MATN4 SVEP1 GP2	1.77e-05	249	85	8	IPR000742
Domain	EGF_CA	FBN2 CELSR3 LRP1 LRP2 MATN4 SVEP1	1.97e-05	122	85	6	SM00179
Domain	EGF_1	FBN2 MALRD1 CELSR3 LRP1 LRP2 MATN4 SVEP1 GP2	2.10e-05	255	85	8	PS00022
Domain	EGF-like_Ca-bd_dom	FBN2 CELSR3 LRP1 LRP2 MATN4 SVEP1	2.16e-05	124	85	6	IPR001881
Domain	EGF	MALRD1 CELSR3 LRP1 LRP2 MATN4 SVEP1	2.37e-05	126	85	6	PF00008
Domain	EGF_CA	FBN2 LRP1 LRP2 MATN4 SVEP1	4.52e-05	86	85	5	PF07645
Domain	ITPRIP_fam	ITPRIPL2 ITPRIPL1	6.12e-05	3	85	2	IPR026250
Domain	Growth_fac_rcpt_	FBN2 EPHA2 LRP1 LRP2 MATN4 SVEP1	7.83e-05	156	85	6	IPR009030
Domain	EGF	FBN2 MALRD1 CELSR3 LRP1 LRP2 MATN4 SVEP1	9.79e-05	235	85	7	SM00181
Domain	Long_hematopoietin_rcpt_CS	MPL GHR	1.22e-04	4	85	2	IPR003528
Domain	HEMATOPO_REC_L_F1	MPL GHR	1.22e-04	4	85	2	PS01352
Domain	PKNOX/Meis_N	MEIS3 MEIS2	2.03e-04	5	85	2	IPR032453
Domain	Growth/epo_recpt_lig-bind	MPL GHR	2.03e-04	5	85	2	IPR015152
Domain	EpoR_lig-bind	MPL GHR	2.03e-04	5	85	2	PF09067
Domain	Meis_PKNOX_N	MEIS3 MEIS2	2.03e-04	5	85	2	PF16493
Domain	LDLR_class-A_CS	MALRD1 LRP1 LRP2	7.96e-04	40	85	3	IPR023415
Domain	EGF_Ca-bd_CS	FBN2 LRP1 LRP2 SVEP1	1.00e-03	97	85	4	IPR018097
Domain	EGF_CA	FBN2 LRP1 LRP2 SVEP1	1.08e-03	99	85	4	PS01187
Domain	Ldl_recept_a	MALRD1 LRP1 LRP2	1.12e-03	45	85	3	PF00057
Domain	-	MALRD1 LRP1 LRP2	1.20e-03	46	85	3	4.10.400.10
Domain	Mab-21_dom	ITPRIPL2 ITPRIPL1	1.31e-03	12	85	2	IPR024810
Domain	Mab-21	ITPRIPL2 ITPRIPL1	1.31e-03	12	85	2	PF03281
Domain	Mab-21	ITPRIPL2 ITPRIPL1	1.31e-03	12	85	2	SM01265
Domain	LDLRA_1	MALRD1 LRP1 LRP2	1.36e-03	48	85	3	PS01209
Domain	LDLRA_2	MALRD1 LRP1 LRP2	1.44e-03	49	85	3	PS50068
Domain	LDrepeatLR_classA_rpt	MALRD1 LRP1 LRP2	1.44e-03	49	85	3	IPR002172
Domain	LDLa	MALRD1 LRP1 LRP2	1.44e-03	49	85	3	SM00192
Domain	FN3	MPL GHR PAPPA2 EPHA2 CMYA5	1.56e-03	185	85	5	SM00060
Domain	Sushi	PAPPA2 CR1 SVEP1	1.71e-03	52	85	3	PF00084
Domain	RasGAP	RASAL3 RASA2	1.80e-03	14	85	2	SM00323
Domain	Ldl_recept_b	LRP1 LRP2	1.80e-03	14	85	2	PF00058
Domain	LDLRB	LRP1 LRP2	1.80e-03	14	85	2	PS51120
Domain	RasGAP_CS	RASAL3 RASA2	1.80e-03	14	85	2	IPR023152
Domain	CCP	PAPPA2 CR1 SVEP1	1.91e-03	54	85	3	SM00032
Domain	RasGAP	RASAL3 RASA2	2.07e-03	15	85	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASAL3 RASA2	2.07e-03	15	85	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASAL3 RASA2	2.07e-03	15	85	2	PS50018
Domain	LY	LRP1 LRP2	2.07e-03	15	85	2	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP2	2.07e-03	15	85	2	IPR000033
Domain	SUSHI	PAPPA2 CR1 SVEP1	2.12e-03	56	85	3	PS50923
Domain	Sushi_SCR_CCP_dom	PAPPA2 CR1 SVEP1	2.23e-03	57	85	3	IPR000436
Domain	-	RASAL3 RASA2	2.36e-03	16	85	2	1.10.506.10
Domain	FN3_dom	MPL GHR PAPPA2 EPHA2 CMYA5	2.66e-03	209	85	5	IPR003961
Domain	Homeobox_KN	MEIS3 MEIS2	2.66e-03	17	85	2	PF05920
Domain	Homeobox_KN_domain	MEIS3 MEIS2	2.66e-03	17	85	2	IPR008422
Domain	RasGAP_dom	RASAL3 RASA2	2.99e-03	18	85	2	IPR001936
Domain	ConA-like_dom	PAPPA2 MALRD1 CELSR3 CMYA5 SVEP1	3.25e-03	219	85	5	IPR013320
Domain	BAR	ACAP1 ACAP2	3.33e-03	19	85	2	PS51021
Domain	Znf_RING	DPF1 TRIM45 UBR1 KMT2C PHRF1 RNF182	3.72e-03	326	85	6	IPR001841
Domain	-	DPF1 TRIM45 UBR1 KMT2C ZNF423 PHRF1 RNF182	4.36e-03	449	85	7	3.30.40.10
Domain	PHD	DPF1 KMT2C PHRF1	4.85e-03	75	85	3	PF00628
Domain	ADAM_spacer1	ADAMTS5 ADAMTSL2	4.87e-03	23	85	2	IPR010294
Domain	ADAM_spacer1	ADAMTS5 ADAMTSL2	4.87e-03	23	85	2	PF05986
Domain	Znf_RING/FYVE/PHD	DPF1 TRIM45 UBR1 KMT2C ZNF423 PHRF1 RNF182	4.91e-03	459	85	7	IPR013083
Domain	Peptidase_M12B_ADAM-TS	ADAMTS5 ADAMTSL2	5.29e-03	24	85	2	IPR013273
Pathway	BIOCARTA_PITX2_PATHWAY	EP300 AXIN1 HDAC1	4.57e-05	16	63	3	M8516
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	VPS9D1 PSMG2 CELSR3 AKAP17A ENPP2 ZNF423 HPS4 LARS1 LRP1 LRP2 KCNQ2 CMYA5 ST18 EP300	4.73e-06	1285	89	14	35914814
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DPF1 FBN2 RASAL3 AKAP17A FIZ1 SCN5A PHRF1 LRP1 LRP2 PRDM16 EP300 ADCY9 HDAC1	5.24e-06	1116	89	13	31753913
Pubmed	Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.	LRP1 ADAMTS5	6.48e-06	2	89	2	28306378
Pubmed	ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.	ACAP1 ACAP2	6.48e-06	2	89	2	11062263
Pubmed	Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.	MATN4 ADAMTS5	6.48e-06	2	89	2	21539915
Pubmed	LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.	LRP1 ADAMTS5	6.48e-06	2	89	2	23064555
Pubmed	Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300.	EP300 HDAC1	6.48e-06	2	89	2	14968110
Pubmed	Expression of histone deacetylase-1 and p300 in aristolochic acid nephropathy models.	EP300 HDAC1	6.48e-06	2	89	2	24796935
Pubmed	Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.	LRP1 LRP2	6.48e-06	2	89	2	34445520
Pubmed	Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.	LRP1 ADAMTS5	1.94e-05	3	89	2	24474687
Pubmed	Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300.	EP300 HDAC1	1.94e-05	3	89	2	27913583
Pubmed	KAPs off for HIV-1 integration.	EP300 HDAC1	1.94e-05	3	89	2	21669392
Pubmed	The TRIM family protein KAP1 inhibits HIV-1 integration.	EP300 HDAC1	1.94e-05	3	89	2	21669397
Pubmed	Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis.	XPA EP300	1.94e-05	3	89	2	11268218
Pubmed	Genetics of migraine in the age of genome-wide association studies.	LRP1 PRDM16	1.94e-05	3	89	2	22072275
Pubmed	The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.	EP300 HDAC1	1.94e-05	3	89	2	15668237
Pubmed	Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice.	MPL EP300	1.94e-05	3	89	2	18684867
Pubmed	Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.	FMO1 FMO6P	1.94e-05	3	89	2	28413702
Pubmed	X-radiation inhibits histone deacetylase 1 and 2, upregulates Axin expression and induces apoptosis in non-small cell lung cancer.	AXIN1 HDAC1	1.94e-05	3	89	2	23110995
Pubmed	An autoinhibitory effect of the homothorax domain of Meis2.	MEIS3 MEIS2	1.94e-05	3	89	2	20553494
Pubmed	Kaiso is a bimodal modulator for Wnt/beta-catenin signaling.	AXIN1 HDAC1	1.94e-05	3	89	2	19166851
Pubmed	Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation.	EP300 HDAC1	1.94e-05	3	89	2	16728531
Pubmed	Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis.	LRP1 PRDM16	1.94e-05	3	89	2	35454329
Pubmed	Acetylation of Sirt2 by p300 attenuates its deacetylase activity.	EP300 HDAC1	1.94e-05	3	89	2	18722353
Pubmed	A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.	EPHA2 LRP1	1.94e-05	3	89	2	21408136
Pubmed	Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2.	EP300 HDAC1	1.94e-05	3	89	2	27635759
Pubmed	Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1.	EP300 HDAC1	1.94e-05	3	89	2	20438716
Pubmed	Regulation of hematopoietic stem cells by their mature progeny.	MPL EP300	1.94e-05	3	89	2	21115812
Pubmed	Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.	EP300 HDAC1	1.94e-05	3	89	2	26549310
Pubmed	Clinical, molecular, and cellular features of non-Puerto Rican Hermansky-Pudlak syndrome patients of Hispanic descent.	HPS4 HPS5	1.94e-05	3	89	2	21833017
Pubmed	Genome-wide association study reveals three susceptibility loci for common migraine in the general population.	LRP1 PRDM16	1.94e-05	3	89	2	21666692
Pubmed	Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.	ACAP1 ACAP2	1.94e-05	3	89	2	11050434
Pubmed	Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription.	EP300 HDAC1	1.94e-05	3	89	2	18486321
Pubmed	Interaction network of human early embryonic transcription factors.	DPF1 RLF KMT2C ZNF423 PRDM16 EP300 HDAC1	3.41e-05	351	89	7	38297188
Pubmed	Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells.	EP300 HDAC1	3.87e-05	4	89	2	15192014
Pubmed	Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site.	EP300 HDAC1	3.87e-05	4	89	2	19062177
Pubmed	Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.	LRP1 LRP2	3.87e-05	4	89	2	12413896
Pubmed	An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis.	C10orf90 HDAC1	3.87e-05	4	89	2	20154723
Pubmed	An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer.	EP300 HDAC1	3.87e-05	4	89	2	35346238
Pubmed	DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor.	PARK7 HDAC1	3.87e-05	4	89	2	16731528
Pubmed	Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.	LRP1 LRP2	3.87e-05	4	89	2	7775583
Pubmed	Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.	FBN2 CDH3	3.87e-05	4	89	2	19469909
Pubmed	STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.	EP300 HDAC1	3.87e-05	4	89	2	16285960
Pubmed	Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter.	EP300 HDAC1	3.87e-05	4	89	2	11115394
Pubmed	Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors.	EP300 HDAC1	3.87e-05	4	89	2	22266186
Pubmed	Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.	EP300 HDAC1	3.87e-05	4	89	2	16478997
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C EP300	3.87e-05	4	89	2	28398509
Pubmed	SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity.	EP300 HDAC1	3.87e-05	4	89	2	22731250
Pubmed	ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons.	ACAP1 ACAP2	3.87e-05	4	89	2	27330119
Pubmed	Acetylation and alternative splicing regulate ZNF76-mediated transcription.	EP300 HDAC1	3.87e-05	4	89	2	16337145
Pubmed	Platelet alpha granules in BLOC-2 and BLOC-3 subtypes of Hermansky-Pudlak syndrome.	HPS4 HPS5	3.87e-05	4	89	2	17365864
Pubmed	Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages.	EP300 HDAC1	3.87e-05	4	89	2	17220375
Pubmed	Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.	LRP1 LRP2	3.87e-05	4	89	2	11421580
Pubmed	Functional architecture of atrophins.	EP300 HDAC1	3.87e-05	4	89	2	17150957
Pubmed	Genetic testing in cardiovascular diseases.	SCN5A PRDM16	3.87e-05	4	89	2	24717670
Pubmed	Substrate specificities and activities of AZAP family Arf GAPs in vivo.	ACAP1 ACAP2	3.87e-05	4	89	2	18003747
Pubmed	Postsynaptic chromatin is under neural control at the neuromuscular junction.	EP300 HDAC1	3.87e-05	4	89	2	17304221
Pubmed	Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex.	EP300 HDAC1	3.87e-05	4	89	2	11517158
Pubmed	Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation.	EP300 HDAC1	3.87e-05	4	89	2	22778253
Pubmed	MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.	LRP1 ADAMTS5	3.87e-05	4	89	2	27084377
Pubmed	The dynamics of stress p53-Mdm2 network regulated by p300 and HDAC1.	EP300 HDAC1	3.87e-05	4	89	2	23437037
Pubmed	Fli1 represses transcription of the human α2(I) collagen gene by recruitment of the HDAC1/p300 complex.	EP300 HDAC1	3.87e-05	4	89	2	24058639
Pubmed	Identification of a conserved family of Meis1-related homeobox genes.	MEIS3 MEIS2	3.87e-05	4	89	2	9049632
Pubmed	Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy.	EP300 HDAC1	3.87e-05	4	89	2	22116549
Pubmed	Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.	ZFAT FBN2 ENPP2	5.64e-05	29	89	3	21998595
Pubmed	The post-translational modifications of proliferating cell nuclear antigen: acetylation, not phosphorylation, plays an important role in the regulation of its function.	EP300 HDAC1	6.44e-05	5	89	2	14988403
Pubmed	SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.	PRDM16 HDAC1	6.44e-05	5	89	2	19049980
Pubmed	Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells.	EP300 HDAC1	6.44e-05	5	89	2	16645043
Pubmed	Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation.	EP300 HDAC1	6.44e-05	5	89	2	16959611
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 LRP2	6.44e-05	5	89	2	19047013
Pubmed	The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.	EP300 HDAC1	6.44e-05	5	89	2	11931769
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LRP1 LRP2	6.44e-05	5	89	2	18685438
Pubmed	ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.	LRP1 LRP2	6.44e-05	5	89	2	16101684
Pubmed	Progenitor cell defect correctable by bone marrow transplantation in five independent mouse models of platelet storage pool deficiency.	HPS4 HPS5	6.44e-05	5	89	2	3516713
Pubmed	Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: alteration of the Sp1/Sp3/HDAC1 multiprotein complex.	EP300 HDAC1	6.44e-05	5	89	2	12200149
Pubmed	Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet function.	HPS4 HPS5	6.44e-05	5	89	2	2369371
Pubmed	Regulation of murine TGFbeta2 by Pax3 during early embryonic development.	EP300 HDAC1	6.44e-05	5	89	2	16787918
Pubmed	A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator.	EP300 HDAC1	6.44e-05	5	89	2	16291753
Pubmed	DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.	PARK7 HDAC1	6.44e-05	5	89	2	12612053
Pubmed	Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1.	PARK7 HDAC1	6.44e-05	5	89	2	18439917
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KMT2C CELSR3 HPS4 PHRF1 LARS1 HPS5 ACAP2 ADCY9	6.52e-05	529	89	8	14621295
Pubmed	ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.	LRP2 MEIS3 MEIS2	6.91e-05	31	89	3	36445780
Pubmed	Cell fate decisions by c-Myc depend on ZBTB5 and p53.	EP300 HDAC1	9.65e-05	6	89	2	33051058
Pubmed	Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2.	EP300 HDAC1	9.65e-05	6	89	2	10933397
Pubmed	Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex.	EP300 HDAC1	9.65e-05	6	89	2	15647279
Pubmed	Transcriptional regulation of BRCA1 expression by a metabolic switch.	EP300 HDAC1	9.65e-05	6	89	2	21102443
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LRP1 LRP2	9.65e-05	6	89	2	9837937
Pubmed	UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs.	EP300 HDAC1	9.65e-05	6	89	2	20037778
Pubmed	Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression.	EP300 HDAC1	9.65e-05	6	89	2	20590529
Pubmed	Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis.	EP300 HDAC1	9.65e-05	6	89	2	26123998
Pubmed	MOZ is essential for maintenance of hematopoietic stem cells.	MPL EP300	9.65e-05	6	89	2	16702405
Pubmed	Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.	LRP1 IDE	9.65e-05	6	89	2	22383525
Pubmed	Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I.	EP300 HDAC1	9.65e-05	6	89	2	16582105
Pubmed	Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.	FMO1 FMO6P	9.65e-05	6	89	2	12527699
Pubmed	Role of Pax3 acetylation in the regulation of Hes1 and Neurog2.	EP300 HDAC1	9.65e-05	6	89	2	21169561
Pubmed	Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.	EP300 HDAC1	9.65e-05	6	89	2	14633989
Pubmed	Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases.	EP300 HDAC1	9.65e-05	6	89	2	21148070
Pubmed	Stat3 dimerization regulated by reversible acetylation of a single lysine residue.	EP300 HDAC1	9.65e-05	6	89	2	15653507
Pubmed	Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells.	EP300 HDAC1	9.65e-05	6	89	2	16734381
Pubmed	A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer.	EP300 HDAC1	9.65e-05	6	89	2	32494626
Cytoband	2p23.2	PLB1 TOGARAM2	2.86e-04	13	89	2	2p23.2
GeneFamily	TALE class homeoboxes and pseudogenes	MEIS3P2 MEIS3 MEIS2	1.19e-04	26	67	3	526
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP17A SPHKAP CMYA5	1.66e-04	29	67	3	396
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASAL3 RASA2	5.97e-04	10	67	2	830
GeneFamily	Low density lipoprotein receptors	LRP1 LRP2	1.03e-03	13	67	2	634
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAPPA2 CR1 SVEP1	1.23e-03	57	67	3	1179
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ACAP1 ACAP2	1.77e-03	17	67	2	1291
GeneFamily	Fibronectin type III domain containing	MPL GHR EPHA2 CMYA5	2.94e-03	160	67	4	555
GeneFamily	PHD finger proteins	DPF1 KMT2C PHRF1	4.54e-03	90	67	3	88
GeneFamily	ArfGAPs	ACAP1 ACAP2	6.63e-03	33	67	2	395
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C PRDM16	7.03e-03	34	67	2	487
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG1 ACAP1 RASA2 ACAP2	7.17e-03	206	67	4	682
GeneFamily	Potassium voltage-gated channels	KCNG2 KCNQ2	9.64e-03	40	67	2	274
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500	GHR PAPPA2 FBN2 ROR1 LRP1 CDH3 SVEP1 MEIS2	2.35e-06	207	88	8	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FMO1 ARSF ATP8A2 LRP2 MEIS2 ADAMTSL2 GP2	7.92e-08	181	89	7	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 ARSF PRICKLE2 LRP1 CMYA5 SVEP1 MEIS2	8.22e-08	182	89	7	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GHR NALF1 ENPP2 ROR1 PRICKLE2 LRP1 SVEP1	1.32e-07	195	89	7	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GHR NALF1 ENPP2 ROR1 PRICKLE2 LRP1 SVEP1	1.36e-07	196	89	7	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	PCW_13-14-Mesenchymal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GHR NALF1 ENPP2 ROR1 PRICKLE2 LRP1 SVEP1	1.41e-07	197	89	7	73a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GHR NALF1 ENPP2 ROR1 PRICKLE2 LRP1 SVEP1	1.46e-07	198	89	7	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PLEKHG1 KCNG2 ARSF LRP1 MEIS3 CMYA5	7.23e-07	156	89	6	bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 LRP1 MEIS3 SVEP1 MEIS2 ADAMTSL2	1.46e-06	176	89	6	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 LRP1 MEIS3 SVEP1 MEIS2 ADAMTSL2	1.46e-06	176	89	6	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D231\|Adult / Lineage, Cell type, age group and donor	COL4A2 PLEKHG1 ZNF423 PRICKLE2 N4BP3 MEIS2	1.95e-06	185	89	6	07f9f38f0739d7c830641723a38385550ac1ac92
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GHR NALF1 ENPP2 ROR1 PRICKLE2 SVEP1	2.08e-06	187	89	6	a9316e2818217ec5feae9cf8816f7249803caee6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MALRD1 FMN1 PRICKLE2 PRDM16 GP2	2.21e-06	189	89	6	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	FBN2 SPHKAP ROR1 CMYA5 PRDM16 MEIS2	2.21e-06	189	89	6	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	GHR ZNF423 MEIS3 ADAMTS5 FRMPD3 SVEP1	2.28e-06	190	89	6	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GHR COL4A2 PRICKLE2 LRP1 SVEP1 ADAMTSL2	2.35e-06	191	89	6	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	facs-Pancreas\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENPP2 SPHKAP RFX6 TMEM215 ST18 MEIS2	2.35e-06	191	89	6	d48e5f67d384226add7d7fb2a124954136e09a82
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GHR COL4A2 PRICKLE2 LRP1 SVEP1 ADAMTSL2	2.35e-06	191	89	6	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GHR ENPP2 SPHKAP TMEM215 ST18 RNF182	2.35e-06	191	89	6	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GHR COL4A2 PRICKLE2 LRP1 SVEP1 ADAMTSL2	2.35e-06	191	89	6	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 LRP1 MEIS3 SVEP1 MEIS2 ADAMTSL2	2.64e-06	195	89	6	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NALF1 ENPP2 SPHKAP RFX6 TMEM215 RNF182	2.64e-06	195	89	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 LRP1 MEIS3 SVEP1 MEIS2 ADAMTSL2	2.64e-06	195	89	6	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	PCW_10-12-Mesenchymal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GHR NALF1 ENPP2 ROR1 PRICKLE2 SVEP1	2.97e-06	199	89	6	a09292de4c4447b8eee55d401808e43b817321cc
ToppCell	COPD-Epithelial-PNEC\|COPD / Disease state, Lineage and Cell class	NALF1 SPHKAP ST18 MEIS2 GP2	1.69e-05	159	89	5	6018124980c55190928409f3bf41d846a118954a
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 FBN2 SPHKAP LRP2 SVEP1	1.74e-05	160	89	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	COPD-Epithelial-PNEC\|World / Disease state, Lineage and Cell class	NALF1 SPHKAP ST18 MEIS2 GP2	1.74e-05	160	89	5	cdea93317b0ebb801ddbe73bca6149ce2c727f16
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 FBN2 SPHKAP LRP2 SVEP1	1.74e-05	160	89	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231\|Adult / Lineage, Cell type, age group and donor	COL4A2 PLEKHG1 CELSR3 PRICKLE2 N4BP3	2.14e-05	167	89	5	5af9127bae05768a5164d5708a4ad37edca99324
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	PLEKHG1 ZNF423 LRP1 CR1 SVEP1	2.68e-05	175	89	5	2eca4c168dea2017ea0e383006e28abed22f32ec
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	NALF1 ATP8A2 SPHKAP SCN5A ST18	2.68e-05	175	89	5	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	NALF1 ATP8A2 SPHKAP SCN5A ST18	2.68e-05	175	89	5	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PRICKLE2 ADAMTS5 CDH3 SVEP1 MEIS2	2.75e-05	176	89	5	bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PRICKLE2 ADAMTS5 CDH3 SVEP1 MEIS2	2.83e-05	177	89	5	3d955ea938a1d2fb1b6d68d4997fd454bd632dfc
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-MPP_Fraction_B\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GHR TSPAN17 FMN1 TMEM215 ST18	2.83e-05	177	89	5	4a697866ed542d3201714234cee03451adf1dcc9
ToppCell	COPD-Epithelial-PNEC\|Epithelial / Disease state, Lineage and Cell class	NALF1 ATP8A2 SPHKAP ST18 GP2	2.99e-05	179	89	5	988d0853c391da1e5004f73f3678047418d3f6d3
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 COL4A2 FBN2 ATP8A2 PRICKLE2	2.99e-05	179	89	5	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GHR FMN1 SPHKAP SCN5A C10orf90	3.07e-05	180	89	5	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	COL4A2 FBN2 SCN5A ADAMTS5 CDH3	3.07e-05	180	89	5	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 LRP1 MEIS3 ADAMTS5 SVEP1	3.15e-05	181	89	5	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	RV\|World / Chamber and Cluster_Paper	FBN2 SPHKAP CMYA5 PRDM16 MEIS2	3.15e-05	181	89	5	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 NALF1 SPHKAP PRICKLE2 CDH3	3.15e-05	181	89	5	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A2 LRP1 MEIS3 ADAMTS5 SVEP1	3.15e-05	181	89	5	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MALRD1 PRICKLE2 PRDM16 GP2	3.40e-05	184	89	5	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBN2 SPHKAP ROR1 SCN5A CMYA5	3.40e-05	184	89	5	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A2 PRICKLE2 LRP1 SVEP1 ADAMTSL2	3.49e-05	185	89	5	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBN2 SPHKAP ROR1 SCN5A CMYA5	3.49e-05	185	89	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	COVID-19-Endothelial_cells-Systemic_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PLEKHG1 NALF1 ENPP2 ZNF423 MEIS2	3.49e-05	185	89	5	f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FMN1 LRP2 C10orf90 PRDM16 CDH3	3.59e-05	186	89	5	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FMN1 LRP2 C10orf90 PRDM16 CDH3	3.68e-05	187	89	5	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GHR COL4A2 SVEP1 MEIS2 ADAMTSL2	3.68e-05	187	89	5	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MALRD1 PRICKLE2 PRDM16 GP2	3.68e-05	187	89	5	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPF1 PAPPA2 ENPP2 ADAMTS5 FRMPD3	3.68e-05	187	89	5	8bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCell	droplet-Pancreas\|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENPP2 RFX6 TMEM215 ST18 GP2	3.68e-05	187	89	5	5f4df092452d8672bda4059c794e099ba3f5a8fa
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 ARSF ROR1 FRMPD3 SVEP1	3.68e-05	187	89	5	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL4A2 PLEKHG1 ENPP2 ADAMTS5 ADAMTSL2	3.68e-05	187	89	5	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	COVID-19-kidney-Stressed_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	GHR ZFAT ENPP2 ROR1 LRP2	3.68e-05	187	89	5	acd305475f3609800af0d7bc68d83ef41228080b
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPF1 PAPPA2 ENPP2 ADAMTS5 FRMPD3	3.68e-05	187	89	5	3cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	FBN2 SPHKAP SCN5A CMYA5 PRDM16	3.68e-05	187	89	5	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.77e-05	188	89	5	89411c4db3df5e1dc36cf8af4ffcc0abbecbe4df
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MALRD1 PRDM16 CDH3 GP2	3.77e-05	188	89	5	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSF SPHKAP ROR1 FRMPD3 SVEP1	3.77e-05	188	89	5	ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	FBN2 SPHKAP ROR1 CMYA5 PRDM16	3.77e-05	188	89	5	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLEKHG1 ENPP2 ZNF423 PRICKLE2 MEIS2	3.77e-05	188	89	5	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.77e-05	188	89	5	de6a270b6e4fe09c39a52c296632d86ada98465b
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 COL4A2 FBN2 ATP8A2 PRICKLE2	3.77e-05	188	89	5	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.77e-05	188	89	5	879054b780378ae05be68e597c77c931bf0ade03
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MALRD1 PRICKLE2 PRDM16 GP2	3.77e-05	188	89	5	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A2 SPHKAP ROR1 TOGARAM2 ADAMTS5	3.77e-05	188	89	5	3139540a656c0436b2123ea50741ff8d00112165
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.87e-05	189	89	5	209cae68d78c8f72479b169e27c3ff7e143adece
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.87e-05	189	89	5	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	SPHKAP ROR1 SCN5A CMYA5 PRDM16	3.87e-05	189	89	5	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GHR NALF1 ENPP2 CMYA5 SVEP1	3.87e-05	189	89	5	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ENPP2 LRP2 C10orf90 PRDM16 ST18	3.87e-05	189	89	5	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.87e-05	189	89	5	a9ad1fb12304541f909dd0eeac9b9eb28c31fd41
ToppCell	COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease group, lineage and cell class	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.87e-05	189	89	5	c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCell	Control-Myeloid-pDC\|Control / Disease group, lineage and cell class	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.87e-05	189	89	5	46770b99da42f11f10cfc67cea8562342d60b867
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 NALF1 PRDM16 CDH3 GP2	3.87e-05	189	89	5	55420853f730b433ef58ac9337ac84ac78a247a0
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.87e-05	189	89	5	98ca646231fbd5f29827c2dd31ac4503026bad7d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GHR COL4A2 LRP1 SVEP1 ADAMTSL2	3.87e-05	189	89	5	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.97e-05	190	89	5	adffa93635da10251f28b2089fd96b189775c8b4
ToppCell	droplet-Mammary_Gland-nan-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 ENPP2 LRP1 ADAMTS5 SVEP1	3.97e-05	190	89	5	bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.97e-05	190	89	5	9a91bf1ea105029e6412d0d9060bca325299ce26
ToppCell	droplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 ENPP2 LRP1 ADAMTS5 SVEP1	3.97e-05	190	89	5	e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GHR LRP1 SVEP1 MEIS2 ADAMTSL2	3.97e-05	190	89	5	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PLEKHG1 LRP2 RFX6 PRDM16 CDH3	3.97e-05	190	89	5	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.97e-05	190	89	5	39c8ddc2639bf3e986dae11fbae61a735614b604
ToppCell	droplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A2 ENPP2 LRP1 ADAMTS5 SVEP1	3.97e-05	190	89	5	ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GHR COL4A2 LRP1 SVEP1 ADAMTSL2	3.97e-05	190	89	5	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.97e-05	190	89	5	2c1c079fd411c03bc3f383aa927eea9446716960
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ENPP2 LRP2 C10orf90 PRDM16 ST18	3.97e-05	190	89	5	07f21386ea6eb23416a537d2250e3042efe93fb0
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.97e-05	190	89	5	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	BLOOD--(3)_MNP-(3)_DC_(cDC+pDC)\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ACAP1 ZFAT EPHA2 PARK7 IDH3A	3.97e-05	190	89	5	9b8de47f7a2e6137d934ccce32417ab15eb54f46
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GHR LRP1 SVEP1 MEIS2 ADAMTSL2	3.97e-05	190	89	5	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.97e-05	190	89	5	6892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GHR COL4A2 LRP1 SVEP1 ADAMTSL2	3.97e-05	190	89	5	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.97e-05	190	89	5	a95aea3aa707fc4574810706341a5f32b3d00209
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KCNG2 ZFAT ENPP2 EPHA2 IDH3A	3.97e-05	190	89	5	18dfa84c62dcf081ce9958a71e76a394ec0968e4
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ENPP2 LRP2 C10orf90 PRDM16 ST18	3.97e-05	190	89	5	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	SPHKAP ROR1 SCN5A CMYA5 PRDM16	3.97e-05	190	89	5	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GHR LRP1 SVEP1 MEIS2 ADAMTSL2	4.07e-05	191	89	5	a58c75e9580139fb370b498d95660f10f3a2a27b
Disease	restless legs syndrome (implicated_via_orthology)	MEIS3P2 MEIS3 MEIS2	1.37e-06	8	87	3	DOID:0050425 (implicated_via_orthology)
Disease	leukemia (implicated_via_orthology)	MEIS3P2 MEIS3 MEIS2	2.32e-05	19	87	3	DOID:1240 (implicated_via_orthology)
Disease	cardiovascular disease	PLEKHG1 PLB1 FBN2 EPHA2 PRDM16 SVEP1 ADCY9 AXIN1	6.25e-05	457	87	8	EFO_0000319
Disease	Hermansky-Pudlak syndrome (is_implicated_in)	HPS4 HPS5	1.79e-04	7	87	2	DOID:3753 (is_implicated_in)
Disease	Adenocarcinoma of large intestine	ROR1 EP300 NEK11 AXIN1	1.90e-04	96	87	4	C1319315
Disease	Abdominal Migraine	LRP1 PRDM16	3.05e-04	9	87	2	C0270858
Disease	Sick Headaches	LRP1 PRDM16	3.05e-04	9	87	2	C0700438
Disease	Acute Confusional Migraine	LRP1 PRDM16	3.05e-04	9	87	2	C0521664
Disease	Status Migrainosus	LRP1 PRDM16	3.05e-04	9	87	2	C0338489
Disease	Cervical Migraine Syndrome	LRP1 PRDM16	3.05e-04	9	87	2	C0007852
Disease	Hemicrania migraine	LRP1 PRDM16	3.05e-04	9	87	2	C0018984
Disease	body weight	GHR PAPPA2 ZFAT FBN2 RASA2 ZNF423 PARK7 SPHKAP ADCY9 NEK11 AXIN1 GP2	3.23e-04	1261	87	12	EFO_0004338
Disease	Hermanski-Pudlak Syndrome	HPS4 HPS5	3.81e-04	10	87	2	C0079504
Disease	Hermansky-Pudlak syndrome	HPS4 HPS5	3.81e-04	10	87	2	cv:C0079504
Disease	autoimmune thyroiditis (is_implicated_in)	ZFAT LRP2	5.56e-04	12	87	2	DOID:7188 (is_implicated_in)
Disease	body surface area	GHR PAPPA2 ZFAT FBN2 ENPP2 PARK7 ADCY9 AXIN1	6.28e-04	643	87	8	EFO_0022196
Disease	Migraine Disorders	LRP1 PRDM16	6.56e-04	13	87	2	C0149931
Disease	pulse pressure measurement	PAPPA2 PLEKHG1 ZFAT PSMG2 FBN2 MALRD1 ENPP2 ZNF423 LRP1 PRDM16 ST18 SVEP1	7.78e-04	1392	87	12	EFO_0005763
Disease	platelet storage pool deficiency (implicated_via_orthology)	HPS4 HPS5	8.80e-04	15	87	2	DOID:2223 (implicated_via_orthology)
Disease	asthma, response to diisocyanate	DPH1 ZFAT PRICKLE2 CMYA5 ADCY9	1.07e-03	261	87	5	EFO_0006995, MONDO_0004979
Disease	colorectal cancer, colorectal adenoma	COL4A2 FMN1 LRP1 CDH3	1.08e-03	152	87	4	EFO_0005406, MONDO_0005575
Disease	anorexia nervosa	NALF1 CELSR3 LRP2	1.18e-03	70	87	3	MONDO_0005351
Disease	peripheral neuropathy, response to docetaxel trihydrate	ATP8A2 SPHKAP	1.42e-03	19	87	2	EFO_0003100, GO_1902519
Disease	cortical thickness	COL4A2 PLEKHG1 FBN2 MALRD1 NALF1 ENPP2 ZNF423 ROR1 LRP1 ST18	1.61e-03	1113	87	10	EFO_0004840
Disease	Antimigraine preparation use measurement	LRP1 PRDM16	1.74e-03	21	87	2	EFO_0009939
Disease	LEOPARD Syndrome	RASA2 EPHA2	1.91e-03	22	87	2	C0175704
Disease	complement factor H-like 1 protein measurement	ATP8A2 KCNQ2	1.91e-03	22	87	2	EFO_0600092
Disease	severe acute respiratory syndrome, COVID-19	COL4A2 MALRD1 NALF1 ATP8A2 PRICKLE2 C10orf90	2.10e-03	447	87	6	EFO_0000694, MONDO_0100096
Disease	Noonan Syndrome	RASA2 EPHA2	2.27e-03	24	87	2	C0028326
Disease	blood manganese measurement	TRIM45 ADCY9	2.88e-03	27	87	2	EFO_0007581

Protein segments in the cluster

Peptide	Gene	Start	Entry
CRFDSDPCIQTIDEI	BHLHB9	281	Q6PI77
FCLCDKEEEVSQPRG	ARSF	571	P54793
NDTLDPELFVECTEC	EP300	1236	Q09472
TICSPERSCAVIEDD	ADAMTS5	386	Q9UNA0
ASLEDRDKPYVCDIC	DPF1	186	Q92782
DEIKPYISRCSVCEA	COL4A2	1581	P08572
TVKLCPDSERRFCFE	ACAP1	316	Q15027
CEDIERRFCFEVVSP	ACAP2	321	Q15057
VACEDCSCRDEKVAP	DPH1	426	Q9BZG8
TVCRKFEDDIDNCPF	CST9	101	Q5W186
PCSDSCDFDDPRLLK	ATP8A2	471	Q9NTI2
RLCASTEDCEVDPSK	RASAL3	531	Q86YV0
LDEICDSSKSCEIDP	RASA2	426	Q15283
DFCRKEKLEPACAAT	RFX6	151	Q8HWS3
TDDDCPPKTFRNVCV	FMN1	791	Q68DA7
ERSKEDANCAVCDSP	KMT2C	336	Q8NEZ4
ELRSPCECESLVEFQ	MATN4	576	O95460
SICSSDKRIACEEEF	HDAC1	406	Q13547
VDEFRCKDSGRCIPA	LRP1	3496	Q07954
LVFEKCELATCTPRE	MEIS2	91	O14770
CAVELPDVSCKRFLD	HPS4	96	Q9NQG7
SVDKTACECVRSPRE	HPS5	701	Q9UPZ3
EERGECSPKCRSLFV	KCNG2	206	Q9UJ96
DIVDDKSCPCEFVTE	KCNQ2	516	O43526
CSRDVVICPDASLED	PARK7	46	Q99497
RDPSTVEDKCEKACR	GP2	181	P55259
EKACRPEEECLALNS	GP2	191	P55259
ECLEKVVPQASDCFE	NEK11	606	Q8NG66
EDPTFCEVCGRSDRE	PHRF1	181	Q9P1Y6
LVFEKCELATCSPRD	MEIS3	71	Q99687
IRCSEDEKLCDPNTR	ADAMTSL2	711	Q86TH1
CLEEGLEPTCFERSD	FMO6P	21	O60774
EENCAPRECTESEFR	LRP2	3751	P98164
SCCELAEEDFLAVSP	NSUN5P1	11	Q3KNT7
KDSSREDSIPCTCDL	GARIN1B	286	Q96KD3
LVFEKCELATCSPRD	MEIS3P2	71	A8K0S8
EEVCRANEPCTSFAE	NCOA4	401	Q13772
LKPRCAACDEIIFAD	PRICKLE2	191	Q7Z3G6
RDLPCTCEFVESFVD	ITPRIPL1	181	Q6GPH6
SELCPEITDFLCRDK	MALRD1	1681	Q5VYJ5
KKVIPFAADCDLDEC	PAPPA2	1766	Q9BXP8
CSDFTEEICRRVKDL	IDH3A	351	P50213
PEAPRCTVKSCDDFL	CR1	1701	P17927
RTSCCEPDILETDFN	GHR	386	P10912
KPAELDEDSESSKCC	FRMPD3	1511	Q5JV73
FKFEASESPCLECPE	EPHA2	281	P29317
CTGFRKLEPCDSNEE	AXIN1	121	O15169
EKREFECDSPICLTS	CMYA5	966	Q8N3K9
CLEEGLEPTCFERSD	FMO1	21	Q01740
DSVNLEEACLERCFP	ADCY9	96	O60503
CSECEKLFRSPRDLE	FIZ1	416	Q96SL8
CPLFDESCKDREVNA	IDE	171	P14735
ESPADLDECSCLEVS	CCDC168	6776	Q8NDH2
ELCPKDDEVAFQDLC	FBN2	2141	P35556
CRPRFTGEDCELDTE	CELSR3	1461	Q9NYQ7
CAASEPCRAVFREAE	CDH3	21	P22223
SDFDLGCTCDDKVEP	ENPP2	561	Q13822
TPAERKCSRLCEAES	C9orf72	256	Q96LT7
LRDCKPFADAFCVDV	ITPRIPL2	226	Q3MIP1
ESLDCPRKDSVTECK	SPHKAP	1366	Q2M3C7
AEELRLFCEFCDRPV	TRIM45	196	Q9H8W5
SFDCAREACPPLKEE	TOGARAM2	326	Q6ZUX3
ASEAEDKIREDCCPG	LARS1	1041	Q9P2J5
PSRLIQCFDTETDKC	KBTBD4	396	Q9NVX7
RFECENCVKVFTDPS	PRDM16	336	Q9HAZ2
DEFCRNTLCAPEVIS	FAF2	186	Q96CS3
VKDPEDCFTEGCVRR	SCN5A	1161	Q14524
FCRFETCLPDDEVSS	RNF182	66	Q8N6D2
CPCVLKFDDNSTELA	PLB1	581	Q6P1J6
AEFCRIDKPLCHSED	STIM1	46	Q13586
PSFCSDAEDIDCRLE	SVEP1	831	Q4LDE5
VAICKETRCETPLEF	SVEP1	3291	Q4LDE5
DKFIPCENRCDSETE	ST18	241	O60284
VAEEAPCKEVQSSCR	AKAP17A	516	Q02040
DSLCPKCRAEDTLFQ	C10orf90	161	Q96M02
FKSDLCDIPACDSKD	ROR1	381	Q01973
CEVCEESFPTQAKLS	ZXDB	366	P98169
SCPVCEKSFSEDRLI	ZFAT	831	Q9P243
FSCCVRDPAEDVLNT	TSPAN17	186	Q96FV3
ALDVKCSARDRSECP	TMEM215	176	Q68D42
ADPCIKKEENRSCES	RLF	1606	Q13129
SADDERKHPVLCLFC	UBR1	1616	Q8IWV7
EPLKCFSRTFEDLTC	MPL	36	P40238
FDLPTCDNCRDADDK	XPA	121	P23025
EEKFEDRSPAAECLS	TRAP1	561	Q12931
FVPCVAALCSDEAER	TRAPPC8	16	Q9Y2L5
SRCIPEIDDSEFCIR	PSMG2	166	Q969U7
LEADFVCCDSLRPFV	PLEKHG1	771	Q9ULL1
RCPECSVKFESAEDL	ZNF423	1121	Q2M1K9
AASKDRCLACIEEPF	VPS9D1	436	Q9Y2B5
ETFLTNDEPECCDVR	NALF1	366	B1AL88
EEAPGSCETDDCKSR	N4BP3	436	O15049