Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	ASIC2 HCN1 HCN2 NALCN	6.63e-06	26	95	4	GO:0005248
GeneOntologyMolecularFunction	20-hydroxy-leukotriene B4 omega oxidase activity	CYP4F2 CYP4F3	2.24e-05	2	95	2	GO:0097258
GeneOntologyMolecularFunction	20-aldehyde-leukotriene B4 20-monooxygenase activity	CYP4F2 CYP4F3	2.24e-05	2	95	2	GO:0097259
GeneOntologyMolecularFunction	sodium channel activity	ASIC2 HCN1 HCN2 NALCN	1.09e-04	52	95	4	GO:0005272
GeneOntologyMolecularFunction	hormone binding	MC4R MC5R PTH1R EDNRB CTSH	1.33e-04	103	95	5	GO:0042562
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F2 CYP4F3	2.22e-04	5	95	2	GO:0052871
GeneOntologyMolecularFunction	melanocortin receptor activity	MC4R MC5R	3.32e-04	6	95	2	GO:0004977
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F2 CYP4F3	4.63e-04	7	95	2	GO:0050051
GeneOntologyMolecularFunction	MutLalpha complex binding	WRN MSH2	4.63e-04	7	95	2	GO:0032405
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F2 CYP4F3	4.63e-04	7	95	2	GO:0018685
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	TNPO1 CSE1L IPO11	4.68e-04	32	95	3	GO:0140142
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN1 HCN2 MCOLN2	5.13e-04	33	95	3	GO:0005217
GeneOntologyMolecularFunction	thiamine pyrophosphate binding	TKTL2 DHTKD1	6.16e-04	8	95	2	GO:0030976
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F2 CYP4F3	9.83e-04	10	95	2	GO:0052869
GeneOntologyMolecularFunction	phosphorylation-dependent protein binding	ANK2 PLCG2	9.83e-04	10	95	2	GO:0140031
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	HCN1 HCN2	9.83e-04	10	95	2	GO:0005222
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3	9.83e-04	10	95	2	GO:0120250
GeneOntologyMolecularFunction	oxidized purine DNA binding	WRN MSH2	9.83e-04	10	95	2	GO:0032357
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3	9.83e-04	10	95	2	GO:0102033
GeneOntologyMolecularFunction	mismatch repair complex binding	WRN MSH2	1.20e-03	11	95	2	GO:0032404
GeneOntologyMolecularFunction	oxidized DNA binding	WRN MSH2	1.20e-03	11	95	2	GO:0032356
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	HCN1 HCN2	1.69e-03	13	95	2	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	HCN1 HCN2	1.69e-03	13	95	2	GO:0043855
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3	1.69e-03	13	95	2	GO:0016713
GeneOntologyMolecularFunction	molecular carrier activity	TNPO1 CYGB CSE1L IPO11	1.77e-03	108	95	4	GO:0140104
GeneOntologyMolecularFunction	cysteine-type endopeptidase regulator activity involved in apoptotic process	VIL1 CARD8 CTSH	2.17e-03	54	95	3	GO:0043028
GeneOntologyMolecularFunction	peptide hormone binding	MC4R PTH1R EDNRB	2.29e-03	55	95	3	GO:0017046
GeneOntologyMolecularFunction	four-way junction DNA binding	WRN MSH2	3.63e-03	19	95	2	GO:0000400
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	MC4R MC5R PTH1R EDNRB	3.75e-03	133	95	4	GO:0008528
GeneOntologyMolecularFunction	nuclear import signal receptor activity	TNPO1 IPO11	4.02e-03	20	95	2	GO:0061608
GeneOntologyMolecularFunction	peptide receptor activity	MC4R MC5R PTH1R EDNRB	4.50e-03	140	95	4	GO:0001653
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	ASIC2 HCN1 HCN2 MCOLN2	4.50e-03	140	95	4	GO:0099094
GeneOntologyCellularComponent	HCN channel complex	HCN1 HCN2	1.22e-04	4	95	2	GO:0098855
Domain	DVL-1	DVL1P1 DVL1	2.61e-05	2	96	2	IPR008340
Domain	IMPORTIN_B_NT	TNPO1 CSE1L IPO11	4.60e-05	14	96	3	PS50166
Domain	CNH	CDC42BPA GARNL3 MINK1	4.60e-05	14	96	3	SM00036
Domain	IBN_N	TNPO1 CSE1L IPO11	5.73e-05	15	96	3	PF03810
Domain	CNH	CDC42BPA GARNL3 MINK1	5.73e-05	15	96	3	PF00780
Domain	CNH	CDC42BPA GARNL3 MINK1	5.73e-05	15	96	3	PS50219
Domain	CNH_dom	CDC42BPA GARNL3 MINK1	5.73e-05	15	96	3	IPR001180
Domain	IBN_N	TNPO1 CSE1L IPO11	7.02e-05	16	96	3	SM00913
Domain	Melancort_rcpt	MC4R MC5R	7.82e-05	3	96	2	IPR001908
Domain	Importin-beta_N	TNPO1 CSE1L IPO11	8.49e-05	17	96	3	IPR001494
Domain	Ion_trans_N	HCN1 HCN2	1.56e-04	4	96	2	PF08412
Domain	Ion_trans_N	HCN1 HCN2	1.56e-04	4	96	2	IPR013621
Domain	Dishevelled_fam	DVL1P1 DVL1	1.56e-04	4	96	2	IPR008339
Domain	Dishevelled	DVL1P1 DVL1	1.56e-04	4	96	2	PF02377
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	1.56e-04	4	96	2	IPR003351
Domain	HSF_fam	HSF1 HSF4	3.87e-04	6	96	2	IPR027725
Domain	Melcrt_ACTH_rcpt	MC4R MC5R	3.87e-04	6	96	2	IPR001671
Domain	HSF_DOMAIN	HSF1 HSF4	5.40e-04	7	96	2	PS00434
Domain	HSF_DNA-bd	HSF1 HSF4	5.40e-04	7	96	2	IPR000232
Domain	HSF	HSF1 HSF4	5.40e-04	7	96	2	SM00415
Domain	HSF_DNA-bind	HSF1 HSF4	5.40e-04	7	96	2	PF00447
Domain	DIX	DVL1P1 DVL1	5.40e-04	7	96	2	PF00778
Domain	DIX	DVL1P1 DVL1	5.40e-04	7	96	2	IPR001158
Domain	DIX	DVL1P1 DVL1	5.40e-04	7	96	2	PS50841
Domain	DAX	DVL1P1 DVL1	5.40e-04	7	96	2	SM00021
Domain	CNMP_BINDING_1	CNBD1 HCN1 HCN2	5.86e-04	32	96	3	PS00888
Domain	CNMP_BINDING_2	CNBD1 HCN1 HCN2	5.86e-04	32	96	3	PS00889
Domain	cNMP_binding	CNBD1 HCN1 HCN2	7.02e-04	34	96	3	PF00027
Domain	Transket_pyr	TKTL2 DHTKD1	7.17e-04	8	96	2	SM00861
Domain	Transket_pyr	TKTL2 DHTKD1	7.17e-04	8	96	2	PF02779
Domain	S1	PNPT1 PDCD11	7.17e-04	8	96	2	PF00575
Domain	Transketolase-like_Pyr-bd	TKTL2 DHTKD1	7.17e-04	8	96	2	IPR005475
Domain	cNMP-bd_dom	CNBD1 HCN1 HCN2	7.64e-04	35	96	3	IPR000595
Domain	CNMP_BINDING_3	CNBD1 HCN1 HCN2	7.64e-04	35	96	3	PS50042
Domain	cNMP-bd-like	CNBD1 HCN1 HCN2	9.74e-04	38	96	3	IPR018490
Domain	-	TNPO1 CAB39 PPP4R4 CSE1L ELMO2 IPO11	1.00e-03	222	96	6	1.25.10.10
Domain	S1	PNPT1 PDCD11	1.15e-03	10	96	2	PS50126
Domain	WHTH_DNA-bd_dom	DVL1P1 FOXN4 WRN DVL1 HSF1 HSF4	1.56e-03	242	96	6	IPR011991
Domain	Homeodomain-like	DUXA LHX9 LHX2 MTA1 PC LCOR PROX1	1.62e-03	332	96	7	IPR009057
Domain	S1	PNPT1 PDCD11	1.67e-03	12	96	2	SM00316
Domain	S1_dom	PNPT1 PDCD11	1.67e-03	12	96	2	IPR022967
Domain	S1_domain	PNPT1 PDCD11	1.67e-03	12	96	2	IPR003029
Domain	-	CNBD1 HCN1 HCN2	1.92e-03	48	96	3	2.60.120.10
Domain	THDP-binding	TKTL2 DHTKD1	1.97e-03	13	96	2	IPR029061
Domain	-	TKTL2 DHTKD1	1.97e-03	13	96	2	3.40.50.970
Domain	OTU	OTUD6A VCPIP1	1.97e-03	13	96	2	PF02338
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN1 HCN2	2.29e-03	14	96	2	IPR003938
Domain	RmlC-like_jellyroll	CNBD1 HCN1 HCN2	2.29e-03	51	96	3	IPR014710
Domain	OTU	OTUD6A VCPIP1	2.63e-03	15	96	2	PS50802
Domain	OTU_dom	OTUD6A VCPIP1	2.63e-03	15	96	2	IPR003323
Domain	ARM-like	TNPO1 CAB39 PPP4R4 CSE1L ELMO2 IPO11	2.70e-03	270	96	6	IPR011989
Domain	Ion_trans_dom	HCN1 HCN2 NALCN MCOLN2	2.84e-03	114	96	4	IPR005821
Domain	Ion_trans	HCN1 HCN2 NALCN MCOLN2	2.84e-03	114	96	4	PF00520
Domain	cNMP-bd_CS	HCN1 HCN2	2.99e-03	16	96	2	IPR018488
Domain	Terpenoid_cyclase/PrenylTrfase	ELMO2 LSS	3.79e-03	18	96	2	IPR008930
Pubmed	Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.	HCN1 ADCY1 LHX9 LHX2	1.11e-06	28	97	4	35942939
Pubmed	Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.	ANK2 DVL1 MAST2 ELMO2	3.50e-06	37	97	4	27565344
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	GTPBP4 CDC42BPA MINK1 TEX15 NEB MAST2 PC	4.38e-06	234	97	7	36243803
Pubmed	Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.	HCN1 HCN2	7.70e-06	2	97	2	19524546
Pubmed	Correlations of MC4R and MSH2 expression with obesity in colon cancer patients.	MC4R MSH2	7.70e-06	2	97	2	28537674
Pubmed	Esophageal cancer risk is associated with polymorphisms of DNA repair genes MSH2 and WRN in Chinese population.	WRN MSH2	7.70e-06	2	97	2	22173703
Pubmed	Copy number variations of DNA repair genes and the age-related cataract: Jiangsu Eye Study.	WRN HSF4	7.70e-06	2	97	2	23329665
Pubmed	HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.	HCN1 HCN2	7.70e-06	2	97	2	21076425
Pubmed	Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.	HCN1 HCN2	7.70e-06	2	97	2	17261842
Pubmed	Hsf4 counteracts Hsf1 transcription activities and increases lens epithelial cell survival in vitro.	HSF1 HSF4	7.70e-06	2	97	2	25601714
Pubmed	An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels.	HCN1 HCN2	7.70e-06	2	97	2	15644313
Pubmed	A leucine zipper motif essential for gating of hyperpolarization-activated channels.	HCN1 HCN2	7.70e-06	2	97	2	23048023
Pubmed	HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons.	HCN1 HCN2	7.70e-06	2	97	2	15525777
Pubmed	HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.	HCN1 HCN2	7.70e-06	2	97	2	22948144
Pubmed	Maintenance of olfactory neurogenesis requires HSF1, a major heat shock transcription factor in mice.	HSF1 HSF4	7.70e-06	2	97	2	16306048
Pubmed	Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex.	LHX9 LHX2	7.70e-06	2	97	2	10330499
Pubmed	Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family.	HCN1 HCN2	7.70e-06	2	97	2	29980633
Pubmed	Processing of retinal signals in normal and HCN deficient mice.	HCN1 HCN2	7.70e-06	2	97	2	22279546
Pubmed	Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.	HCN1 HCN2	7.70e-06	2	97	2	12562911
Pubmed	Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.	HCN1 HCN2	7.70e-06	2	97	2	24638995
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	7.70e-06	2	97	2	8644734
Pubmed	Cell-type-dependent access of HSF1 and HSF4 to αB-crystallin promoter during heat shock.	HSF1 HSF4	7.70e-06	2	97	2	23264262
Pubmed	Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.	HCN1 HCN2	7.70e-06	2	97	2	20130205
Pubmed	SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.	LPL SORL1	7.70e-06	2	97	2	21385844
Pubmed	Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.	HCN1 HCN2	7.70e-06	2	97	2	12034718
Pubmed	In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality.	HCN1 HCN2	7.70e-06	2	97	2	19171659
Pubmed	Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.	CYP4F2 CYP4F3	7.70e-06	2	97	2	8026587
Pubmed	Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.	HCN1 HCN2	7.70e-06	2	97	2	18579800
Pubmed	Hyperpolarization-activated cation current contributes to spontaneous network activity in developing neocortical cultures.	HCN1 HCN2	7.70e-06	2	97	2	22094222
Pubmed	Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.	HCN1 HCN2	7.70e-06	2	97	2	17931874
Pubmed	Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.	HCN1 HCN2	7.70e-06	2	97	2	12890777
Pubmed	Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.	HCN1 HCN2	7.70e-06	2	97	2	29047147
Pubmed	Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes.	HCN1 HCN2	7.70e-06	2	97	2	12433951
Pubmed	Functional heteromerization of HCN1 and HCN2 pacemaker channels.	HCN1 HCN2	7.70e-06	2	97	2	11133998
Pubmed	Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).	HCN1 HCN2	7.70e-06	2	97	2	32543742
Pubmed	MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.	HCN1 HCN2	7.70e-06	2	97	2	11420311
Pubmed	The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.	TNPO1 FPGT CSE1L PLCG2 CDK11B	1.02e-05	102	97	5	37024974
Pubmed	LDB1 Is Required for the Early Development of the Dorsal Telencephalon and the Thalamus.	LHX9 LHX2 PROX1	1.15e-05	16	97	3	30873428
Pubmed	An Early Cortical Progenitor-Specific Mechanism Regulates Thalamocortical Innervation.	LHX9 LHX2 PROX1	1.15e-05	16	97	3	34193558
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	TNPO1 ELOC MINK1 MSH2 RFC3 MTA1 CSE1L IPO11	1.66e-05	399	97	8	37536630
Pubmed	Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development.	FOXN4 LHX2 PROX1	1.66e-05	18	97	3	25794677
Pubmed	Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala.	MC4R LHX9 LHX2	1.97e-05	19	97	3	33492553
Pubmed	The inhibition of CMV promoter by heat shock factor 4b is regulated by Daxx.	HSF1 HSF4	2.31e-05	3	97	2	20620219
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN1 HCN2	2.31e-05	3	97	2	22652004
Pubmed	Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.	CYP4F2 CYP4F3	2.31e-05	3	97	2	15145985
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN1 HCN2	2.31e-05	3	97	2	21187420
Pubmed	HCN channels expressed in the inner ear are necessary for normal balance function.	HCN1 HCN2	2.31e-05	3	97	2	22090507
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN1 HCN2	2.31e-05	3	97	2	21945247
Pubmed	The impact of CYP4F2, ABCB1, and GGCX polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation.	CYP4F2 ABCB1	2.31e-05	3	97	2	27662649
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN1 HCN2	2.31e-05	3	97	2	22006928
Pubmed	Heat shock-induced interactions among nuclear HSFs detected by fluorescence cross-correlation spectroscopy.	HSF1 HSF4	2.31e-05	3	97	2	26003728
Pubmed	Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome.	HCN1 HCN2	2.31e-05	3	97	2	22662315
Pubmed	Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.	MC4R MC5R	2.31e-05	3	97	2	17482720
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN1 HCN2	2.31e-05	3	97	2	33181864
Pubmed	Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.	HCN1 HCN2	2.31e-05	3	97	2	22880098
Pubmed	Chromosomal localization of the zinc finger protein 15, Zfp15, on mouse chromosome 4.	DVL1 ZNF292	2.31e-05	3	97	2	7613041
Pubmed	Roles of the heat shock transcription factors in regulation of the heat shock response and beyond.	HSF1 HSF4	2.31e-05	3	97	2	11344080
Pubmed	Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1-deficient mice.	HSF1 HSF4	2.31e-05	3	97	2	17652588
Pubmed	Interaction of the pacemaker channel HCN1 with filamin A.	HCN1 HCN2	2.31e-05	3	97	2	15292205
Pubmed	HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator.	HSF1 HSF4	2.31e-05	3	97	2	8972228
Pubmed	Genetic variation in MDR1, LPL and eNOS genes and the response to atorvastatin treatment in ischemic stroke.	ABCB1 LPL	2.31e-05	3	97	2	22810051
Pubmed	A family of hyperpolarization-activated mammalian cation channels.	HCN1 HCN2	2.31e-05	3	97	2	9634236
Pubmed	Barhl2 Determines the Early Patterning of the Diencephalon by Regulating Shh.	LHX9 LHX2 PROX1	2.32e-05	20	97	3	27349434
Pubmed	Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.	PDK4 CASD1 DYNC1I1	2.32e-05	20	97	3	16341224
Pubmed	BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain.	LHX9 LHX2 PROX1	4.08e-05	24	97	3	36263009
Pubmed	Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium.	LHX9 LHX2 PROX1	4.08e-05	24	97	3	15858069
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	DVL1 MAST2 ELMO2 RBM19 MRPL38 VCPIP1	4.25e-05	226	97	6	25900982
Pubmed	Functional expression of the human HCN3 channel.	HCN1 HCN2	4.60e-05	4	97	2	16043489
Pubmed	Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system.	LHX9 LHX2	4.60e-05	4	97	2	12351192
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN1 HCN2	4.60e-05	4	97	2	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN1 HCN2	4.60e-05	4	97	2	12928435
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN1 HCN2	4.60e-05	4	97	2	20140458
Pubmed	Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis.	ABCB1 LPL	4.60e-05	4	97	2	18336668
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN1 HCN2	4.60e-05	4	97	2	22748890
Pubmed	Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1.	MINK1 HSF1	4.60e-05	4	97	2	26496226
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN1 HCN2	4.60e-05	4	97	2	9630217
Pubmed	Common genetic variation near MC4R is associated with waist circumference and insulin resistance.	MC4R LPL	4.60e-05	4	97	2	18454146
Pubmed	Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.	HCN1 HCN2	4.60e-05	4	97	2	25042871
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1	4.60e-05	4	97	2	8817329
Pubmed	Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.	HCN1 HCN2	4.60e-05	4	97	2	26966193
Pubmed	Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus.	LHX9 LHX2	4.60e-05	4	97	2	21690374
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1	4.60e-05	4	97	2	9192851
Pubmed	Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice.	HCN1 HCN2	4.60e-05	4	97	2	21593326
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	4.60e-05	4	97	2	20639201
Pubmed	Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.	HCN1 HCN2	4.60e-05	4	97	2	21615589
Pubmed	Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates.	LHX9 LHX2	4.60e-05	4	97	2	35247020
Pubmed	Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain.	LHX9 LHX2	4.60e-05	4	97	2	9880598
Pubmed	WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.	WRN RFC3	4.60e-05	4	97	2	14657243
Pubmed	Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.	MC4R MC5R	4.60e-05	4	97	2	15470082
Pubmed	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.	CYP4F2 CYP4F3	4.60e-05	4	97	2	18065749
Pubmed	Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.	HCN1 HCN2	7.66e-05	5	97	2	15564593
Pubmed	Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes.	LHX9 LHX2	7.66e-05	5	97	2	20599893
Pubmed	Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1.	MTA1 HSF1	7.66e-05	5	97	2	17922035
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	HCN1 HCN2	7.66e-05	5	97	2	16177047
Pubmed	Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.	HCN1 HCN2	7.66e-05	5	97	2	34429357
Pubmed	Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds.	LHX9 LHX2	7.66e-05	5	97	2	19923199
Pubmed	Molecular cloning, expression, and characterization of a fifth melanocortin receptor.	MC4R MC5R	7.66e-05	5	97	2	8185570
Pubmed	Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.	HCN1 HCN2	7.66e-05	5	97	2	30886335
Pubmed	Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.	CYP4F2 CYP4F3	7.66e-05	5	97	2	18577768
Pubmed	Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.	WRN MSH2	7.66e-05	5	97	2	17715146
Interaction	HCN4 interactions	HCN1 HCN2 STXBP1	8.89e-06	9	97	3	int:HCN4
Cytoband	20q13	CSE1L ELMO2	4.46e-04	15	96	2	20q13
Cytoband	Ensembl 112 genes in cytogenetic band chr7q21	PDK4 ABCB1 CASD1 DYNC1I1	5.50e-04	178	96	4	chr7q21
GeneFamily	Melanocortin receptors	MC4R MC5R	1.23e-04	5	64	2	236
GeneFamily	Cyclic nucleotide gated channels	HCN1 HCN2	5.45e-04	10	64	2	250
GeneFamily	LIM class homeoboxes	LHX9 LHX2	7.96e-04	12	64	2	522
GeneFamily	OTU domain containing	OTUD6A VCPIP1	1.62e-03	17	64	2	669
GeneFamily	Armadillo repeat containing\|Importins	TNPO1 IPO11	1.82e-03	18	64	2	596
GeneFamily	Cytochrome P450 family 4	CYP4F2 CYP4F3	7.19e-03	36	64	2	1003
Coexpression	HEVNER_CORTEX_CAUDAL_CORTICAL_PLATE	ASIC2 HCN1 LHX9 SV2B	4.73e-06	31	95	4	MM439
Coexpression	GSE9960_HEALTHY_VS_GRAM_POS_SEPSIS_PBMC_DN	TNPO1 GTPBP4 PCGF5 METTL1 PNPT1 LSS MCOLN2	7.70e-06	197	95	7	M7121
Coexpression	GSE360_CTRL_VS_L_DONOVANI_MAC_UP	ELOC CDC42BPA ORC4 PDCD11 PLCG2 HSF1 PC	8.49e-06	200	95	7	M5157
Coexpression	GSE33162_HDAC3_KO_VS_HDAC3_KO_4H_LPS_STIM_MACROPHAGE_UP	CAB39 GTPBP4 CSE1L PIP4K2A CDK11B ZNF292 SORL1	8.49e-06	200	95	7	M9041
Coexpression	BROWNE_HCMV_INFECTION_48HR_UP	VIL1 MSH2 RFC3 PLCG2 HSF4 PC	5.06e-05	180	95	6	M19929
Coexpression	GARY_CD5_TARGETS_UP	CAB39 MINK1 MAST2 PCGF5 MTA1 LSS HSF1 DHTKD1 SORL1	5.60e-05	473	95	9	M17693
Coexpression	GSE24671_BAKIMULC_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_DN	TEX15 ORC4 CSE1L STXBP1 PC MMUT	8.81e-05	199	95	6	M9448
Coexpression	GSE27786_CD4_VS_CD8_TCELL_DN	TEX15 PTH1R ELMO2 KICS2 MRPL38 DYNC1I1	8.81e-05	199	95	6	M4821
Coexpression	GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_DN	CAB39 ANK2 MSH2 METTL1 MRPL38 MCOLN2	8.81e-05	199	95	6	M6507
Coexpression	GSE7831_1H_VS_4H_INFLUENZA_STIM_PDC_DN	HCN1 HCN2 PIERCE1 PIP4K2A GRAMD2B SORL1	8.81e-05	199	95	6	M6964
Coexpression	BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_CALU3_CELLS_DN	TEX15 NEB PIERCE1	8.83e-05	24	95	3	M34013
Coexpression	GSE34156_TLR1_TLR2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_24H_TREATED_MONOCYTE_DN	GTPBP4 ANK2 PCGF5 PIP4K2A KICS2 CTSH	9.05e-05	200	95	6	M8691
Coexpression	AIZARANI_LIVER_C11_HEPATOCYTES_1	PDK4 CYP4F2 VNN1 CYP4F3 DHTKD1 MMUT PROX1	1.08e-04	298	95	7	M39115
Coexpression	BILD_MYC_ONCOGENIC_SIGNATURE	METTL1 PNPT1 KICS2 PC MCOLN2 SORL1	1.15e-04	209	95	6	M2069
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 CDC42BPA PDK4 FBXL5 PNPT1 LPL GRAMD2B	1.11e-07	176	96	7	1dd54bfaa58541de51e5a8328651d390833bd480
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	ANK2 HCN1 ADCY1 NALCN SV2B DYNC1I1	2.20e-06	175	96	6	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	ANK2 HCN1 ADCY1 NALCN SV2B DYNC1I1	2.20e-06	175	96	6	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 PTH1R CYP4F3 PC DHTKD1 CTSH	2.59e-06	180	96	6	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	ANK2 HCN1 NALCN SV2B DYNC1I1 PROX1	2.77e-06	182	96	6	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	ANK2 PDK4 ASB18 NALCN LPL DYNC1I1	4.11e-06	195	96	6	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	IPF-Epithelial-Ionocyte\|Epithelial / Disease state, Lineage and Cell class	ANK2 ASIC2 PLCG2 SORL1 PROX1	2.37e-05	158	96	5	67adf625a959444762d32268b3b7441f6f8b3b8c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASIC2 HCN1 CYGB ADCY1 DYNC1I1	3.00e-05	166	96	5	ec7bd549bda5f18aca8aebce5ba479a81abbbeda
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NALCN FBXO39 CTSH IPO11 PROX1	3.00e-05	166	96	5	941d6aa94ab9d36e5f6c40f446c926754e070d56
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NALCN FBXO39 CTSH IPO11 PROX1	3.00e-05	166	96	5	6f5ecf3b2cf613ae0535ab3d21d93622f1497571
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|343B / Donor, Lineage, Cell class and subclass (all cells)	VIL1 FNBP1 MINK1 LCOR MCOLN2	3.27e-05	169	96	5	2098f15a388d019ed7f1d4c209affd5ca2886dcc
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANK2 PDK4 ASB18 LPL DYNC1I1	3.36e-05	170	96	5	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	THNSL1 STXBP1 PIERCE1 HSF4 PC	3.36e-05	170	96	5	c1f7f1bb8865e954bb499963d82bb51923d5d8d6
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	TEX15 PPP4R4 LHX9 LHX2 SV2B	3.97e-05	176	96	5	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	COVID-19-Epithelial-Ionocytes\|Epithelial / Condition, Lineage and Cell class	ANK2 ASIC2 PLCG2 SORL1 PROX1	4.53e-05	181	96	5	4a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANK2 PDK4 ASB18 LPL DYNC1I1	4.53e-05	181	96	5	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ACTR5 WRN CSE1L LSS MCOLN2	4.65e-05	182	96	5	c98da2db197b1531204e116600ff51891e5c17af
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 CYP4F2 PTH1R CYP4F3 PC	4.77e-05	183	96	5	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DUXA ORC4 STXBP1 NEK5 DYNC1I1	4.77e-05	183	96	5	0e468daed40c28dca64a9bc2867b46e4ea9d1a06
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCN1 CYGB ADCY1 STXBP1 DYNC1I1	4.90e-05	184	96	5	7d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANK2 ASB18 NALCN LPL DYNC1I1	4.90e-05	184	96	5	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANK2 PDK4 ASB18 LPL DYNC1I1	5.03e-05	185	96	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCN1 CYGB STXBP1 NALCN DYNC1I1	5.03e-05	185	96	5	70de48988c1f8e0809afc8092b663aa439d8e528
ToppCell	Control-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	CYGB ABCB1 LHX9 GRAMD2B PLCG2	5.03e-05	185	96	5	520795866d44def5be3910ce8e728045c716a24d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCN1 CYGB ADCY1 STXBP1 DYNC1I1	5.03e-05	185	96	5	c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDK4 EDNRB SV2B PLCG2 PROX1	5.16e-05	186	96	5	20340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HCN1 CYGB ADCY1 STXBP1 DYNC1I1	5.29e-05	187	96	5	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 ASIC2 NEB SV2B PROX1	5.43e-05	188	96	5	1f912ea015f50570e848259d948a0ba682d64bb4
ToppCell	Fetal_29-31_weeks-Immune-natural_killer_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCB1 PIP4K2A GRAMD2B PLCG2 SORL1	5.43e-05	188	96	5	6686dbba990066568aa7573e70a7db8b4758f457
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANK2 HCN1 NALCN SV2B PROX1	5.43e-05	188	96	5	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	21-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	ANK2 NEB ADCY1 SV2B PROX1	5.43e-05	188	96	5	e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SAMD7 ASB18 PIERCE1 PIP4K2A SORL1	5.56e-05	189	96	5	159b0979c93b7d98aaeeb43fba5983a9f67b9c9d
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 ASIC2 NEK5 PIERCE1 PROX1	5.56e-05	189	96	5	cd4746ea6ae48a7dd14a2960d38d9445a738cf2c
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 NEB ADCY1 SV2B PROX1	5.70e-05	190	96	5	40d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 NEB ADCY1 SV2B PROX1	5.70e-05	190	96	5	f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDK4 ADCY1 LPL SORL1 PROX1	5.70e-05	190	96	5	68ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 NEB ADCY1 SV2B PROX1	5.70e-05	190	96	5	a9a705455019e28d655636de73b07540798f82e6
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDK4 ADCY1 LPL SORL1 PROX1	5.70e-05	190	96	5	010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EDNRB NALCN DYNC1I1 IPO11 PROX1	6.45e-05	195	96	5	590c0dc0db4dc62879645ed7f61292ff97d2c7d5
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CNBD1 ASIC2 PLCG2 SORL1 PROX1	6.61e-05	196	96	5	a4cc02ea41479d24044bd2ca6441f85d683c0ca9
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP4F2 LHX9 LHX2 SV2B PROX1	6.61e-05	196	96	5	95544097577f20ed7f4144bd940471cde0617554
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 ASIC2 LHX9 ASB18 PROX1	6.61e-05	196	96	5	72b6a68ee760599ea86cd2d712bfd17b7b4ee417
ToppCell	5'-Adult-LymphNode-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EDNRB LPL DYNC1I1 IPO11 PROX1	6.93e-05	198	96	5	d7e15e61b6018e4c36461c9471ee29601929925c
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	ANK2 ADCY1 EDNRB SV2B LPL	7.27e-05	200	96	5	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EDNRB SV2B DYNC1I1 IPO11 PROX1	7.27e-05	200	96	5	c59f262b2b0a7e7dcb2940d1e466f98db6c56625
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	ANK2 ADCY1 STXBP1 LPL DYNC1I1	7.27e-05	200	96	5	c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EDNRB SV2B DYNC1I1 IPO11 PROX1	7.27e-05	200	96	5	e50ef394e3284a8323bfd60575b262b2be422aea
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	HCN1 MINK1 DVL1 RBM19 HSF4	7.27e-05	200	96	5	be46efc899d06c55ee297bee3126f69bcdb2048b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	ANK2 ADCY1 EDNRB SV2B LPL	7.27e-05	200	96	5	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-MAIT\|ICU-NoSEP / Disease, condition lineage and cell class	CDC42BPA DVL1 ABCB1 VNN1 KICS2	7.27e-05	200	96	5	4f03b5f4110ed1637ffe17cb6ff309265a3af9a8
ToppCell	(09)_Ionocytes-(3)_72hpi\|(09)_Ionocytes / shred by cell type and Timepoint	GTPBP4 ACTR5 ELMO2 LCOR	9.45e-05	110	96	4	fce7d5a0617fc664b657f5bb9abb290e7cc234cb
ToppCell	RV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	PDK4 FPGT ASB18 LPL	1.41e-04	122	96	4	1cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
Computational	Neighborhood of MAPT	ANK2 STXBP1 SV2B DYNC1I1	1.11e-04	41	66	4	GNF2_MAPT
Drug	Fluocinonide [356-12-7]; Up 200; 8uM; PC3; HT_HG-U133A	MINK1 TEX15 ADCY1 EDNRB PPP4R4 SV2B HSF1	1.50e-05	190	95	7	4314_UP
Drug	Saquinavir	ASIC2 HCN1 ABCB1 SV2B LPL	1.77e-05	77	95	5	ctd:D019258
Drug	Dequalinium dichloride [522-51-0]; Down 200; 7.6uM; MCF7; HT_HG-U133A	MINK1 NEB ATP13A2 ADCY1 LHX2 CSE1L VCPIP1	1.83e-05	196	95	7	5396_DN
Drug	quercetin dihydrate; Down 200; 1uM; MCF7; HT_HG-U133A_EA	THNSL1 ATP13A2 CARD8 FBXL5 PIP4K2A PLCG2 ZNF292	1.96e-05	198	95	7	917_DN
Drug	Benzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	THNSL1 PDK4 MINK1 MAST2 PPP4R4 CSE1L ELMO2	2.02e-05	199	95	7	4294_DN
Drug	Ciprofibrate [52214-84-3]; Down 200; 13.8uM; PC3; HT_HG-U133A	CDC42BPA MINK1 PPP4R4 ORC4 MTA1 RBM19 PC	2.02e-05	199	95	7	5740_DN
Drug	Mebhydroline 1,5-naphtalenedisulfonate [6153-33-9]; Down 200; 4.8uM; MCF7; HT_HG-U133A	GTPBP4 CDC42BPA NEB FBXL5 LHX2 CSE1L ZNF292	2.02e-05	199	95	7	4795_DN
Disease	meningitis (biomarker_via_orthology)	HCN1 HCN2	9.62e-06	2	92	2	DOID:9471 (biomarker_via_orthology)
Disease	metabolite measurement	CYP4F2 PCGF5 FBXL5 UGT1A4 PNPT1 LPL FBXO39 DHTKD1 SORL1	6.43e-05	560	92	9	EFO_0004725
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	9.56e-05	5	92	2	DOID:11198 (is_implicated_in)
Disease	thyroxine measurement	ASIC2 MC4R UGT1A4 LHX2	1.35e-04	83	92	4	EFO_0005130
Disease	visual epilepsy (biomarker_via_orthology)	HCN1 MSH2 HCN2 ABCB1	1.84e-04	90	92	4	DOID:11832 (biomarker_via_orthology)
Disease	familial hyperlipidemia (is_implicated_in)	ABCB1 LPL	2.66e-04	8	92	2	DOID:1168 (is_implicated_in)
Disease	polycystic ovary syndrome, type 2 diabetes mellitus	MC4R PROX1	4.26e-04	10	92	2	EFO_0000660, MONDO_0005148
Disease	Celiac Disease	UGT1A4 VNN1 LPL	4.31e-04	47	92	3	C0007570
Disease	Parkinson Disease, Secondary Vascular	ATP13A2 ABCB1	6.22e-04	12	92	2	C0751414
Disease	Atherosclerotic Parkinsonism	ATP13A2 ABCB1	6.22e-04	12	92	2	C0751415
Disease	Secondary Parkinson Disease	ATP13A2 ABCB1	6.22e-04	12	92	2	C0030569
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	ADCY1 PNPT1	7.33e-04	13	92	2	C1846647
Disease	Congenital total cataract	LSS HSF4	1.12e-03	16	92	2	C0266539
Disease	Colorectal Carcinoma	ANK2 WRN MSH2 ABCB1 CSE1L CTSH ZNF292 SORL1	1.59e-03	702	92	8	C0009402
Disease	end stage renal disease (implicated_via_orthology)	GTPBP4 ABCB1	1.76e-03	20	92	2	DOID:783 (implicated_via_orthology)
Disease	Epilepsy, Cryptogenic	HCN1 ABCB1 STXBP1	2.17e-03	82	92	3	C0086237
Disease	Awakening Epilepsy	HCN1 ABCB1 STXBP1	2.17e-03	82	92	3	C0751111
Disease	Aura	HCN1 ABCB1 STXBP1	2.17e-03	82	92	3	C0236018
Disease	chronic widespread pain	ASB18 PLCG2	2.33e-03	23	92	2	EFO_0010099
Disease	Parkinson Disease	ATP13A2 ABCB1 MTA1	2.41e-03	85	92	3	C0030567
Disease	Dyslipidemias	VNN1 LPL	2.54e-03	24	92	2	C0242339
Disease	Dyslipoproteinemias	VNN1 LPL	2.54e-03	24	92	2	C0598784
Disease	hair color	CDC42BPA ASIC2 MC4R EDNRB LHX2	2.93e-03	311	92	5	EFO_0003924
Disease	blood urea nitrogen measurement	TNPO1 VIL1 CDC42BPA HCN1 SORL1 PROX1	2.94e-03	452	92	6	EFO_0004741
Disease	cataract (is_implicated_in)	LSS HSF4	2.98e-03	26	92	2	DOID:83 (is_implicated_in)
Disease	Neurodevelopmental Disorders	ANK2 STXBP1 ZNF292	3.11e-03	93	92	3	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFTTKDKCPYMAFHN	CATSPERE	576	Q5SY80
MAHYNFKKITVVPSA	GTPBP4	1	Q9BZE4
HNFTIMTKYISKPEN	CAB39	241	Q9Y376
LLHPVQKTAFMQFYK	EDNRB	256	P24530
DSLFSFYHNKPKNSM	ACTR5	166	Q9H9F9
VKKMTFSEHPYNNLR	CDK11B	671	P21127
FPLDSLQQEMSKYKH	DHTKD1	841	Q96HY7
ALEKLNYKFPATVHM	DAPL1	66	A0PJW8
NYKFPATVHMAHQKP	DAPL1	71	A0PJW8
YKPKQFSMLEFLHRV	ASIC2	146	Q16515
AFITFMFPEHAVKAY	RBM19	446	Q9Y4C8
NSYILFKKDNPEHTM	PGBD4	466	Q96DM1
EANAYDFIMKLPHKF	ABCB1	506	P08183
PVFNKSAFKHYQMSS	PDK4	376	Q16654
YMAKFVVFAKSHDPI	ANK2	1326	Q01484
SYMKKHVDEFLPFFS	OTUD6A	176	Q7L8S5
AHSVYNFEKPVVMKA	ORC4	361	O43929
HEMPKVFYPNSNKFS	PIERCE1	71	Q5BN46
MATQRKHLVKDFNPY	PCGF5	1	Q86SE9
DPAQKDTMLGKFYHF	IFT122	931	Q9HBG6
EEVFQMHKPFYQSLF	ASB18	401	Q6ZVZ8
TLEAHKIKMAFFTYP	IPO11	346	Q9UI26
MKFKKTTPEYVFHCQ	DYNC1I1	326	O14576
VLPKYFKHNNMASFV	HSF1	56	Q00613
AKPHYEFNLSRMKFR	LCOR	196	Q96JN0
TMKSYFAINHNPDAK	LHX9	281	Q9NQ69
KTRSQMPYKVFHYQV	LPL	331	P06858
EKMKHPNIVAFFNSF	NEK5	56	Q6P3R8
HHLAVYNSPQFKKTM	FBXO39	206	Q8N4B4
AVMQALKYFHKRFPE	LSS	536	P48449
MKSYFAINHNPDAKD	LHX2	281	P50458
ELSFEQFHLFYKKLM	PLCG2	196	P16885
LKNMLLAKFSFYFHE	KICS2	261	Q96MD2
EMADLNFFTLKYKHV	ADCY1	581	Q08828
PINFKFYKHSMKFVA	ATP13A2	416	Q9NQ11
FYKHSMKFVAALSVL	ATP13A2	421	Q9NQ11
YKQVEQYMSFHKLPA	HCN1	411	O60741
MKENKFYTHSSFFIP	CASD1	391	Q96PB1
LPLHQFYMSFKDAKI	C2CD3	901	Q4AC94
TKDYKMLGFTNHINP	ELMO2	346	Q96JJ3
FNEFMTSKPKIHCFR	FNBP1	371	Q96RU3
AKQYFSQFKHMEDPL	CYGB	56	Q8WWM9
HFSKFYAGQMKEPIQ	CARD8	401	Q9Y2G2
HFNILKPYMKIFNES	CYP4F2	156	P78329
PSHVLSKVCMYFTYK	ELOC	66	Q15369
QFSDMSFAEIKHKYL	CTSH	81	P09668
KEVLPQYFKHSNMAS	HSF4	56	Q9ULV5
MNHVYKERFPKATAQ	MAST2	316	Q6P0Q8
KNKNLHSPMYFFICS	MC4R	71	P32245
IVKNKNLHSPMYFFV	MC5R	61	P33032
PVHAYKFFFKSMDQD	DVL1	41	O14640
HFNILKPYMKIFNES	CYP4F3	156	Q08477
SLYATFKEFKMHEQI	FBXL5	46	Q9UKA1
PVHAYKFFFKSMDQD	DVL1P1	41	P54792
YKANMHFHKLFLSVP	GRAMD2B	106	Q96HH9
SQLHTLIKAFMKNPY	DUXA	111	A6NLW8
YMSFHKLPADFRQKI	HCN2	486	Q9UL51
IPNDVYFEKDKQMFH	MSH2	651	P43246
QHYKKGTMFPSNETL	MCOLN2	166	Q8IZK6
FHVSTMLPYSKENKQ	GARNL3	276	Q5VVW2
LHKPSIEKMYQFNAV	FPGT	241	O14772
SHFKFKEYCPMVFRN	PIP4K2A	86	P48426
SKAIYHLEAFVAKFM	RFC3	326	P40938
KPYHKFMAFKSFADL	MINK1	1146	Q8N4C8
SFMKEHFPYFKTAPD	FOXN4	221	Q96NZ1
FFKISNLKMGHNYTF	SORL1	2081	Q92673
KIIYHTSFDVMKQNP	SULT1C3	231	Q6IMI6
VFVDPKNFHMELYST	PPP4R4	386	Q6NUP7
NYKMSYVAHPVEKRF	SAXO1	206	Q8IYX7
NDKFTRMYFKHVLFE	SV2B	456	Q7L1I2
SQHVGSMFYKKTLSF	SAMD7	386	Q7Z3H4
SPNHLKKAKLMFFYT	PROX1	581	Q92786
QVTCLKMYFGHSSFK	WRN	536	Q14191
PKFAMKTRQAFYLHT	MTA1	461	Q13330
NGIKDKNFMLHYEFP	PNPT1	416	Q8TCS8
DSFQSFYSPHKAQMK	STXBP1	151	P61764
YGKIMNHKERFQFPA	CDC42BPA	291	Q5VT25
SAHDTFMKQYPKVFL	CNBD1	61	Q8NA66
MHLDPKKAGTYFSNQ	PDCD11	311	Q14690
AMSHALNFIKAKQYP	VIL1	311	P09327
SKNPSKPHFNHYMFE	CSE1L	606	P55060
FFHKKEMEPISIYFS	VSIG1	61	Q86XK7
NFLASNIHYPSKKMT	VNN1	261	O95497
FDFYKKHQETMTPAG	MRPL38	301	Q96DV4
LHSLIFMAFFSEKKY	PTH1R	306	Q03431
VLFFHTMKYKQTDPE	TKTL2	51	Q9H0I9
TAHPDQYAAFKMQRK	ZNF292	1121	O60281
AHYSKFAPAIMQALK	THNSL1	666	Q8IYQ7
NVYDVAMKLVTKHFP	VCPIP1	621	Q96JH7
NIMIPKFLQFFKHSS	TNPO1	181	Q92973
TSFPVKAYVMLHQKS	ZPBP	66	Q9BS86
NHYPKTKIFQFLKMT	ERVK-19	436	Q9WJR5
KYMKDTLNPNTVHTF	TEX15	2581	Q9BXT5
APYVAHNFSKLFSME	PC	591	P11498
AMKHLPNFFYKGQLT	METTL1	141	Q9UBP6
NMHIKEEKFFTLTAY	UGT1A4	66	P22310
AKMYDITQHPFFKRT	NALCN	1201	Q8IZF0
FEYTAKHMPKFNSIS	MMUT	246	P22033
KYNTPHDMFNVVAAK	NEB	1136	P20929