Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of intestinal lipid absorption	ABCG5 ABCG8	4.00e-05	2	131	2	GO:1904730
GeneOntologyBiologicalProcess	negative regulation of intestinal cholesterol absorption	ABCG5 ABCG8	4.00e-05	2	131	2	GO:0045796
GeneOntologyBiologicalProcess	negative regulation of intestinal phytosterol absorption	ABCG5 ABCG8	4.00e-05	2	131	2	GO:0010949
GeneOntologyBiologicalProcess	intestinal phytosterol absorption	ABCG5 ABCG8	4.00e-05	2	131	2	GO:0060752
Domain	Cadherin_tail	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	5.31e-06	37	129	5	PF15974
Domain	Cadherin_CBD	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	5.31e-06	37	129	5	IPR031904
Domain	Cadherin_2	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	8.62e-05	65	129	5	PF08266
Domain	Cadherin_N	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	8.62e-05	65	129	5	IPR013164
Domain	Cadherin_CS	DSG3 PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.09e-04	109	129	6	IPR020894
Domain	CADHERIN_1	DSG3 PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.33e-04	113	129	6	PS00232
Domain	Cadherin	DSG3 PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.33e-04	113	129	6	PF00028
Domain	CADHERIN_2	DSG3 PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.40e-04	114	129	6	PS50268
Domain	-	DSG3 PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.40e-04	114	129	6	2.60.40.60
Domain	CA	DSG3 PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.47e-04	115	129	6	SM00112
Domain	Cadherin-like	DSG3 PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.54e-04	116	129	6	IPR015919
Domain	Cadherin	DSG3 PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.69e-04	118	129	6	IPR002126
Domain	ABC2_membrane	ABCG5 ABCG8	4.67e-04	5	129	2	PF01061
Domain	ABC_2_trans	ABCG5 ABCG8	4.67e-04	5	129	2	IPR013525
Pathway	WP_FATTY_ACID_BETAOXIDATION	ACADS DECR1 LIPE ACSL5	4.97e-05	34	85	4	M39596
Pathway	WP_FATTY_ACID_BETAOXIDATION	ACADS DECR1 LIPE ACSL5	4.97e-05	34	85	4	MM15937
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	2.47e-09	15	136	5	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	5.06e-09	17	136	5	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	6.98e-09	18	136	5	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	6.98e-09	18	136	5	10662547
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	3.40e-08	24	136	5	24698270
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 FRAS1 PIEZO1 SLCO4A1 FHIP1B SLC29A2 ITPR2 PTPRS TRIM28 AHNAK USP40 SEC16A SAC3D1 SENP2 HERC2 CAMSAP1 CABIN1 DOCK6 AHNAK2	6.72e-08	1105	136	19	35748872
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA11 PCDHA10 PCDHA7 PCDHA5	7.23e-08	11	136	4	9655502
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	7.76e-08	28	136	5	15347688
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PRUNE2 RTEL1 ADGRV1 ESYT2 METTL13 MRTFB SEC16A SENP2 DOP1B	2.78e-07	225	136	9	12168954
Pubmed	Control of TurboID-dependent biotinylation intensity in proximity ligation screens.	TRAPPC11 MAN2A1 CLASP1 ITPR2 ESYT2 SEC16A	2.82e-06	100	136	6	36966971
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	3.02e-06	57	136	5	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	3.29e-06	58	136	5	30377227
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PMS2P2 PRUNE2 BDP1 ZNF609 MAP2 ERV3-1 RTEL1 ZC3H8 IQCN ADGRV1 BPTF ESYT2 MRTFB KIDINS220 PTPRS ANKAR NUP210 USP40 DOCK6	5.75e-06	1489	136	19	28611215
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	7.26e-06	68	136	5	11230163
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2 ABCG5	7.73e-06	119	136	6	28625976
Pubmed	Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial.	ACE ABCG5 ABCG8	9.43e-06	11	136	3	20413122
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	9.63e-06	72	136	5	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.10e-05	74	136	5	10817752
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.18e-05	75	136	5	15372022
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA11 PCDHA7 PCDHA5	1.25e-05	12	136	3	10612399
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.34e-05	77	136	5	10835267
Pubmed	Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment.	ABCG5 ABCG8	1.52e-05	2	136	2	25060694
Pubmed	Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.	ABCG5 ABCG8	1.52e-05	2	136	2	11099417
Pubmed	Identification of a novel mutation for phytosterolemia. Genetic analyses of 2 cases.	ABCG5 ABCG8	1.52e-05	2	136	2	19111681
Pubmed	Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution.	ABCG5 ABCG8	1.52e-05	2	136	2	16867993
Pubmed	Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster.	ABCG5 ABCG8	1.52e-05	2	136	2	12150943
Pubmed	ABCG5/8 variants are associated with susceptibility to coronary heart disease.	ABCG5 ABCG8	1.52e-05	2	136	2	24691589
Pubmed	Disruption of cholesterol homeostasis by plant sterols.	ABCG5 ABCG8	1.52e-05	2	136	2	15372105
Pubmed	A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.	ABCG5 ABCG8	1.52e-05	2	136	2	17632509
Pubmed	Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8.	ABCG5 ABCG8	1.52e-05	2	136	2	18509196
Pubmed	ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans.	ABCG5 ABCG8	1.52e-05	2	136	2	12220438
Pubmed	Sitosterolemia	ABCG5 ABCG8	1.52e-05	2	136	2	23556150
Pubmed	ABCG5 and ABCG8 genetic variants in familial hypercholesterolemia.	ABCG5 ABCG8	1.52e-05	2	136	2	32088153
Pubmed	Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8.	ABCG5 ABCG8	1.52e-05	2	136	2	12208859
Pubmed	Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.	ABCG5 ABCG8	1.52e-05	2	136	2	12208868
Pubmed	Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.	ABCG5 ABCG8	1.52e-05	2	136	2	12208867
Pubmed	Recent Advances in the Critical Role of the Sterol Efflux Transporters ABCG5/G8 in Health and Disease.	ABCG5 ABCG8	1.52e-05	2	136	2	32705597
Pubmed	Molecular mechanisms of subcellular localization of ABCG5 and ABCG8.	ABCG5 ABCG8	1.52e-05	2	136	2	19270375
Pubmed	Plasma campesterol and ABCG5/ABCG8 gene loci on the risk of cholelithiasis and cholecystitis: evidence from Mendelian randomization and colocalization analyses.	ABCG5 ABCG8	1.52e-05	2	136	2	38347599
Pubmed	Mutations in the human ATP-binding cassette transporters ABCG5 and ABCG8 in sitosterolemia.	ABCG5 ABCG8	1.52e-05	2	136	2	12124998
Pubmed	Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia.	ABCG5 ABCG8	1.52e-05	2	136	2	11668628
Pubmed	Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstan stimulated membrane ATPase activity.	ABCG5 ABCG8	1.52e-05	2	136	2	17055487
Pubmed	ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion.	ABCG5 ABCG8	1.52e-05	2	136	2	14504269
Pubmed	Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8.	ABCG5 ABCG8	1.52e-05	2	136	2	11907139
Pubmed	Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8.	ABCG5 ABCG8	1.52e-05	2	136	2	18402465
Pubmed	Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport.	ABCG5 ABCG8	1.52e-05	2	136	2	21209088
Pubmed	Single nucleotide polymorphisms in ABCG5 and ABCG8 are associated with changes in cholesterol metabolism during weight loss.	ABCG5 ABCG8	1.52e-05	2	136	2	17827468
Pubmed	The Complex ABCG5/ABCG8 Regulates Vitamin D Absorption Rate and Contributes to its Efflux from the Intestine.	ABCG5 ABCG8	1.52e-05	2	136	2	34510707
Pubmed	Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor.	ABCG5 ABCG8	1.52e-05	2	136	2	23790976
Pubmed	The ABCG5 ABCG8 sterol transporter and phytosterols: implications for cardiometabolic disease.	ABCG5 ABCG8	1.52e-05	2	136	2	19306529
Pubmed	Compound heterozygous mutations in ABCG5 or ABCG8 causing Chinese familial Sitosterolemia.	ABCG5 ABCG8	1.52e-05	2	136	2	32166861
Pubmed	ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin.	ABCG5 ABCG8	1.52e-05	2	136	2	14703505
Pubmed	Serum sitosterol level predicting ABCG5 or ABCG8 genetic mutations.	ABCG5 ABCG8	1.52e-05	2	136	2	32275988
Pubmed	ABCG5 and ABCG8 Are Involved in Vitamin K Transport.	ABCG5 ABCG8	1.52e-05	2	136	2	36839356
Pubmed	ABCG5 and ABCG8 gene variations associated with sitosterolemia and platelet dysfunction.	ABCG5 ABCG8	1.52e-05	2	136	2	32546081
Pubmed	Polymorphisms in ABCG5 and ABCG8 transporters and plasma cholesterol levels.	ABCG5 ABCG8	1.52e-05	2	136	2	15311998
Pubmed	The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.	AHNAK AHNAK2	1.52e-05	2	136	2	15007166
Pubmed	Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice.	ABCG5 ABCG8	1.52e-05	2	136	2	12763362
Pubmed	ATP-binding cassette G5/G8 deficiency causes hypertriglyceridemia by affecting multiple metabolic pathways.	ABCG5 ABCG8	1.52e-05	2	136	2	21855652
Pubmed	Screening of ABCG5 and ABCG8 Genes for Sitosterolemia in a Familial Hypercholesterolemia Cascade Screening Program.	ABCG5 ABCG8	1.52e-05	2	136	2	35549507
Pubmed	ABCG5 and ABCG8 gene polymorphisms in type 2 diabetes mellitus in the Turkish population.	ABCG5 ABCG8	1.52e-05	2	136	2	26088706
Pubmed	The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux.	ABCG5 ABCG8	1.52e-05	2	136	2	17825296
Pubmed	ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph.	ABCG5 ABCG8	1.52e-05	2	136	2	25676339
Pubmed	Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone.	ABCG5 ABCG8	1.52e-05	2	136	2	28268212
Pubmed	ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects.	ABCG5 ABCG8	1.52e-05	2	136	2	15816807
Pubmed	Timely diagnosis of sitosterolemia by next generation sequencing in two children with severe hypercholesterolemia.	ABCG5 ABCG8	1.52e-05	2	136	2	28521186
Pubmed	ATP binding cassette G8 T400K polymorphism may affect the risk of gallstone disease among Chinese males.	ABCG5 ABCG8	1.52e-05	2	136	2	17612515
Pubmed	Relative roles of ABCG5/ABCG8 in liver and intestine.	ABCG5 ABCG8	1.52e-05	2	136	2	25378657
Pubmed	Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls.	ABCG5 ABCG8	1.52e-05	2	136	2	19012522
Pubmed	Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity.	ABCG5 ABCG8	1.52e-05	2	136	2	15175352
Pubmed	Hepatic ABCG5/G8 overexpression substantially increases biliary cholesterol secretion but does not impact in vivo macrophage-to-feces RCT.	ABCG5 ABCG8	1.52e-05	2	136	2	26520893
Pubmed	Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.	ABCG5 ABCG8	1.52e-05	2	136	2	11452359
Pubmed	Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation.	ABCG5 ABCG8	1.52e-05	2	136	2	19019257
Pubmed	ABCG5/ABCG8 in cholesterol excretion and atherosclerosis.	ABCG5 ABCG8	1.52e-05	2	136	2	24252657
Pubmed	Recent advances in ABCG5 and ABCG8 variants.	ABCG5 ABCG8	1.52e-05	2	136	2	33395105
Pubmed	Cholelithiasis in Patients with Gaucher Disease type 1: Risk Factors and the Role of ABCG5/ABCG8 Gene Variants.	ABCG5 ABCG8	1.52e-05	2	136	2	27981300
Pubmed	Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice.	ABCG5 ABCG8	1.52e-05	2	136	2	16151694
Pubmed	The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease.	ABCG5 ABCG8	1.52e-05	2	136	2	19217458
Pubmed	Evidence that the adenosine triphosphate-binding cassette G5/G8-independent pathway plays a determinant role in cholesterol gallstone formation in mice.	ABCG5 ABCG8	1.52e-05	2	136	2	27014967
Pubmed	Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice.	ABCG5 ABCG8	1.52e-05	2	136	2	15102882
Pubmed	Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia.	ABCG5 ABCG8	1.52e-05	2	136	2	20172523
Pubmed	Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease.	ABCG5 ABCG8	1.52e-05	2	136	2	18457353
Pubmed	Are plasma lipid levels related to ABCG5/ABCG8 polymorphisms? A preliminary study in siblings with gallstones.	ABCG5 ABCG8	1.52e-05	2	136	2	17098593
Pubmed	Sitosterolemia: Twenty Years of Discovery of the Function of ABCG5ABCG8.	ABCG5 ABCG8	1.52e-05	2	136	2	33807969
Pubmed	Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterol.	ABCG5 ABCG8	1.52e-05	2	136	2	17626266
Pubmed	Rare and Deleterious Mutations in ABCG5/ABCG8 Genes Contribute to Mimicking and Worsening of Familial Hypercholesterolemia Phenotype.	ABCG5 ABCG8	1.52e-05	2	136	2	31327807
Pubmed	Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.	ABCG5 ABCG8	1.52e-05	2	136	2	18156627
Pubmed	ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis.	ABCG5 ABCG8	1.52e-05	2	136	2	20581104
Pubmed	Selective sterol accumulation in ABCG5/ABCG8-deficient mice.	ABCG5 ABCG8	1.52e-05	2	136	2	14657202
Pubmed	Gallstone disease in Swedish twins: risk is associated with ABCG8 D19H genotype.	ABCG5 ABCG8	1.52e-05	2	136	2	20497293
Pubmed	Purification and ATP hydrolysis of the putative cholesterol transporters ABCG5 and ABCG8.	ABCG5 ABCG8	1.52e-05	2	136	2	16893193
Pubmed	Cholesterol and saturated fat intake determine the effect of polymorphisms at ABCG5/ABCG8 genes on lipid levels in children.	ABCG5 ABCG8	1.52e-05	2	136	2	16980816
Pubmed	The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation.	ABCG5 ABCG8	1.52e-05	2	136	2	22715101
Pubmed	Bile acids stimulate ATP hydrolysis in the purified cholesterol transporter ABCG5/G8.	ABCG5 ABCG8	1.52e-05	2	136	2	20210363
Pubmed	Liver transplantation in a patient with sitosterolemia and cirrhosis.	ABCG5 ABCG8	1.52e-05	2	136	2	16472606
Pubmed	AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.	AHNAK AHNAK2	1.52e-05	2	136	2	20833135
Pubmed	ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels.	ABCG5 ABCG8	1.52e-05	2	136	2	22655090
Pubmed	Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene.	ABCG5 ABCG8	1.52e-05	2	136	2	31901240
Pubmed	Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion.	ABCG5 ABCG8	1.52e-05	2	136	2	12444248
Pubmed	Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus.	ABCG5 ABCG8	1.52e-05	2	136	2	22898925
Interaction	PCDHA10 interactions	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	2.49e-07	22	130	5	int:PCDHA10
Cytoband	5q31	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	2.50e-05	115	136	5	5q31
GeneFamily	Clustered protocadherins	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	9.87e-06	64	81	5	20
GeneFamily	Blood group antigens\|CD molecules\|ATP binding cassette subfamily G	ABCG5 ABCG8	1.97e-04	5	81	2	811
GeneFamily	Myosin light chains\|EF-hand domain containing	MYL2 MYL10	1.74e-03	14	81	2	657
GeneFamily	Sulfotransferases, cytosolic	SULT1C4 SULT1A2	1.74e-03	14	81	2	762
GeneFamily	Ubiquitin specific peptidases	USP16 USP6 USP40	2.02e-03	56	81	3	366
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PTCRA POM121L2 WDFY4 PTPRS TTC39A MTCL1 AHNAK2	9.32e-07	171	135	7	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PTCRA POM121L2 WDFY4 PTPRS TTC39A MTCL1 AHNAK2	9.32e-07	171	135	7	debbb071d260639b16269c94d172766908325c58
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 PIEZO1 SPINK4 TTC39A RFLNA PADI2 DOP1B	2.31e-06	196	135	7	847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 PIEZO1 SPINK4 TTC39A RFLNA PADI2 DOP1B	2.39e-06	197	135	7	d624f3a105b19f19a0dd253ce8de3ed13adc1f01
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TPO PAK4 PCDHA10 PCDHA7 PCDHA5 ACE	4.40e-06	140	135	6	b9aeb7dda7f377b580dd8a44912f300721437387
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDFY4 PTPN7 NUP210 TMEM131L TTC39A PADI2	4.40e-06	140	135	6	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	Ionocyte\|World / Class top	MAP2 SLCO4A1 ACE ITPR2 KIDINS220 AGL	1.34e-05	170	135	6	d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCell	droplet-Heart-4Chambers-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4A1 UBALD2 LIPE KITLG MYL10 DOCK6	1.48e-05	173	135	6	9a04271c51fae34f547db3206f9ff5857686e45c
ToppCell	facs-Heart-LV-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYL2 PIEZO1 SLCO4A1 CXCR5 CSRNP1 PTPN7	1.97e-05	182	135	6	6dff753d65ba45db81f3cc0c9f59e1779d490955
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 SLCO4A1 ADGRV1 SLC13A2 ACE ADCY8	2.03e-05	183	135	6	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	MON2 CLASP1 ITPR2 KIDINS220 TMEM131L DOP1B	2.22e-05	186	135	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	MON2 BDP1 FRAS1 MAN2A1 ITPR2 BPTF	2.66e-05	192	135	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	MON2 BDP1 FRAS1 MAN2A1 ITPR2 BPTF	2.74e-05	193	135	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	RNPC3 IQCN ADGRV1 SLC13A2 PADI2 ACSL5	3.07e-05	197	135	6	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	THEMIS DSG3 PBK NR4A3 PTPN7 AHNAK	3.07e-05	197	135	6	d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCell	5'-Adult-SmallIntestine\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC7A7 SLC13A2 ACE ABCG5 ABCG8 ACSL5	3.25e-05	199	135	6	a5fffe381be1ba7d192b68d1d3937ce47663658e
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PTCRA NR4A3 WDFY4 EYS PTPRS PADI2	3.34e-05	200	135	6	6a34e07e6d77fe3fdd9ff44c4b1e46a023f6d6a2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	PIEZO1 NR4A3 SLC7A7 IRF9 MYOZ1 ACSL5	3.34e-05	200	135	6	25f4c051c2e869481f33c22ad54de97efac444ad
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	PIEZO1 NR4A3 SLC7A7 IRF9 MYOZ1 ACSL5	3.34e-05	200	135	6	da45a85a4667965b24ba824af871157af5b4cd19
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A	MON2 ERCC6 ACADS PTCRA RTEL1 ITPR2 KIDINS220 KITLG MAP4K2	2.60e-06	197	134	9	6060_DN
Disease	1,5 anhydroglucitol measurement	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2	1.68e-07	29	130	5	EFO_0008009
Disease	visceral adipose tissue measurement, body mass index	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2 RFLNA	2.45e-06	87	130	6	EFO_0004340, EFO_0004765
Disease	sitosterolemia (implicated_via_orthology)	ABCG5 ABCG8	1.93e-05	2	130	2	DOID:0090019 (implicated_via_orthology)
Disease	Sitosterolemia	ABCG5 ABCG8	1.93e-05	2	130	2	C0342907
Disease	Macrothrombocytopenia-Stomatocytosis, Mediterranean	ABCG5 ABCG8	1.93e-05	2	130	2	C2749759
Disease	sitosterolemia (is_implicated_in)	ABCG5 ABCG8	1.93e-05	2	130	2	DOID:0090019 (is_implicated_in)
Disease	Familial hypercholesterolemia - homozygous	ABCG5 ABCG8	5.76e-05	3	130	2	C0342881
Disease	hypertrophic cardiomyopathy 10 (implicated_via_orthology)	MYL2 MYL10	1.91e-04	5	130	2	DOID:0110316 (implicated_via_orthology)
Disease	response to platinum based chemotherapy, cytotoxicity measurement	FRAS1 EYS	1.91e-04	5	130	2	EFO_0004647, EFO_0006952
Disease	Lipid Metabolism, Inborn Errors	DECR1 ABCG5	2.86e-04	6	130	2	C0023772
Disease	renal overload-type gout	SPATA31C2 SPATA31C1	2.86e-04	6	130	2	EFO_0021525
Disease	Nonsyndromic Deafness	BDP1 ADGRV1 MYO3A KITLG	4.60e-04	81	130	4	C3711374
Disease	neutrophil count, basophil count	PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2 KITLG	4.88e-04	224	130	6	EFO_0004833, EFO_0005090
Disease	eosinophil cationic protein measurement	SPATA31C2 SPATA31C1	5.30e-04	8	130	2	EFO_0010913
Disease	longitudinal alcohol consumption measurement	SPATA31C2 SPATA31C1	6.80e-04	9	130	2	EFO_0007645
Disease	Hypercholesterolemia	NR4A3 ABCG5 ABCG8	6.80e-04	39	130	3	C0020443
Disease	nevus count, cutaneous melanoma	RTEL1 ADGRV1 KITLG HERC2	7.15e-04	91	130	4	EFO_0000389, EFO_0004632
Disease	pigmentation disease (is_implicated_in)	KITLG HERC2	1.03e-03	11	130	2	DOID:10123 (is_implicated_in)
Disease	campesterol measurement	SLC7A7 ABCG8	1.03e-03	11	130	2	EFO_0020008
Disease	cholestasis (biomarker_via_orthology)	ACE ABCG5 ABCG8	1.33e-03	49	130	3	DOID:13580 (biomarker_via_orthology)
Disease	egg allergy measurement, parental genotype effect measurement	SPATA31C2 SPATA31C1	1.46e-03	13	130	2	EFO_0005939, EFO_0007018
Disease	post-traumatic stress disorder	PCDHA7 PCDHA5 PCDHA2 ADCY8 BPTF	2.05e-03	202	130	5	EFO_0001358
Disease	Blood Platelet Disorders	ABCG5 ABCG8	2.22e-03	16	130	2	C0005818
Disease	amygdala volume change measurement	SPATA31C2 SPATA31C1	2.22e-03	16	130	2	EFO_0021490
Disease	cutaneous melanoma, hair color	ADGRV1 AHNAK HERC2	2.61e-03	62	130	3	EFO_0000389, EFO_0003924
Disease	fat body mass	PRUNE2 SPATA31C1 C3orf20 ADCY8 CXCR5	2.80e-03	217	130	5	EFO_0005409
Disease	age at onset, Parkinson disease	DSG3 TMEM175	2.81e-03	18	130	2	EFO_0004847, MONDO_0005180
Disease	Hypercholesterolemia, Familial	ABCG5 ABCG8	2.81e-03	18	130	2	C0020445
Disease	Coronary Arteriosclerosis	ACE ABCG5 ABCG8	2.99e-03	65	130	3	C0010054
Disease	Coronary Artery Disease	ACE ABCG5 ABCG8	2.99e-03	65	130	3	C1956346
Disease	Abnormality of refraction	TSHZ3 PRNT PCDHA11 PCDHA10 PCDHA7 PCDHA5 PCDHA2 ITPR2 RFLNA	3.03e-03	673	130	9	HP_0000539
Disease	vital capacity	ACADS MAP2 PIEZO1 PCDHA11 PCDHA10 POM121L2 PCDHA7 PCDHA5 PCDHA2 WARS2 ADCY8 SENP2 MTCL1	3.23e-03	1236	130	13	EFO_0004312
Disease	Sclerocystic Ovaries	ISYNA1 PTCRA TNPO2 PBK	3.84e-03	144	130	4	C1136382
Disease	Polycystic Ovary Syndrome	ISYNA1 PTCRA TNPO2 PBK	3.84e-03	144	130	4	C0032460
Disease	lung cancer (is_implicated_in)	ERCC6 RTEL1 ACE	4.31e-03	74	130	3	DOID:1324 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
APMDPLKGILLGFFT	ADCY8	206	P40145
TIRPSFFLMPLKQGE	ERV3-1	441	Q14264
MPLVGALSIFFLRKP	ESYT2	311	A0FGR8
FTDATAQFMPNPLLP	BDP1	2301	A6H8Y1
TEGPLMASFKAVFVP	CXCR5	41	P32302
QNKGISAFLVPMPTP	ACADS	206	P16219
MVVPFPDKPNLDVTS	ACE	296	P12821
LQFSTGLPPQPKDAM	ADGRV1	1706	Q8WXG9
LPSPTKMPGAVQQFT	ABCG8	386	Q9H221
DLPSVNLSMPKVSGP	AHNAK	5286	Q09666
KPVMQPLPAGAFLEE	CISH	31	Q9NSE2
PLEFPKSSEDLMVPN	BPTF	226	Q12830
EQLLMKSPTVPVPGS	CAMSAP1	1046	Q5T5Y3
KLGTLPVFMEQFSVP	ERCC6	696	Q03468
LLSPPIMVNKETQFP	IQCN	181	Q9H0B3
MDISPFLPEKGLPST	MTCL1	1396	Q9Y4B5
LSLGAAMTQPPPEKT	PTPN7	16	P35236
VPFSAVLPMVAPNDL	ISYNA1	121	Q9NPH2
FSKPVGIRPFLVSIM	ITPR2	2281	Q14571
INDNPPIFPMTVKTI	PCDHA2	126	Q9Y5H9
KEAPGPINFTVFLTM	MYL2	71	P10916
LLKNFSSPLPSPAGM	MAP4K2	636	Q12851
AILKLAFPPQFIGSM	SLC10A4	346	Q96EP9
PKDSLTLLPPVTNFM	ANKAR	1366	Q7Z5J8
TLLPPVTNFMGLFKA	ANKAR	1371	Q7Z5J8
SPFFVPKILVNMAAG	OXSM	176	Q9NWU1
KTDLMAFSPSLPQGP	PCDHA7	766	Q9UN72
VAQFKFTVLLMPNGP	PA2G4	316	Q9UQ80
LSDFMPLPVLQAISP	NUP210	1466	Q8TEM1
FKIVSQEPAGTPMFL	DSG3	196	P32926
PFTGPFMAVLFAKLE	FHIP1B	736	Q8N612
EGPPKTDLMAFSPSL	PCDHA11	761	Q9Y5I1
FPSLAPPIMLLVDGK	PTCRA	26	Q6ISU1
KLMFVNPPELPEQTT	KIDINS220	576	Q9ULH0
SLPPMPQKDLSSIFR	MAPK11	261	Q15759
MFNIAILPQTPEAPK	FRAS1	1451	Q86XX4
LLSPSMSPIFPAKVI	EYS	1486	Q5T1H1
PVIPMANKFSSPTLE	MAN2A1	1016	Q16706
SPFKQSMSLTPPLIE	DNAAF2	641	Q9NVR5
TFPLAKPPMNNELGD	CSRNP1	331	Q96S65
PPFNRMLLEVTFGKL	HERC2	1721	O95714
LDTALSFPPDKMPLF	DOP1B	2156	Q9Y3R5
PLEFKPALMLGTFSI	KIAA1109	2506	Q2LD37
LTRVPMDAFQVGKFP	TPO	701	P07202
FPCLPLGSLMKTPDL	PRAMEF18	61	Q5VWM3
VDQGIMPPLKSPAAF	MRTFB	56	Q9ULH7
MSTLLLNLDFGEPPP	ISG20L2	1	Q9H9L3
PGNPVFSCMLDPKTL	PIERCE2	31	H3BRN8
KEAPGPINFTVFLTM	MYL10	131	Q9BUA6
EALVPFKDFMQPPAS	MON2	1696	Q7Z3U7
EAPPKTDLMAFSPSL	PCDHA5	761	Q9Y5H7
MSFVPIPGTKKFLLL	PADI2	476	Q9Y2J8
PFSSKPFLLIPMSNT	PRNT	31	Q86SH4
LSKIPMPVNFNEPLS	OSBP	431	P22059
PSVAPKPDADGFIMV	PTPRS	1126	Q13332
GLPKADLMAFSPSLP	PCDHA10	761	Q9Y5I2
QVMEIFPLTFGEKPA	PODNL1	156	Q6PEZ8
SKFFSPLQKAMLPPN	DECR1	41	Q16698
MLPPNSFQGKVAFIT	DECR1	51	Q16698
NMPKLVIPSAATKFP	CABIN1	2131	Q9Y6J0
PKVTSMFELSGPFRQ	DOCK6	1091	Q96HP0
PINKPFMLPSLADVS	QRSL1	261	Q9H0R6
PETKGPRQMAVFSLP	FRMPD3	1491	Q5JV73
VSFGAPLVVLMEPTF	C3orf20	71	Q8ND61
SGFLRNIQEMPIPFK	ABCG5	546	Q9H222
DIFVFKVLPMLNPDG	AGBL2	491	Q5U5Z8
GFTPSLKVIILMDPF	ACSL5	201	Q9ULC5
LFPSIVKNMPTKPNG	MAK	371	P20794
ESSMEQVLFPKPGPL	IRF9	251	Q00978
PVTGQSSMLPAFLKP	KLF11	291	O14901
AFIMTKFRPVPGSAL	METTL13	206	Q8N6R0
LAFMLPVATPPNAIV	SLC13A2	511	Q13183
FSTPKGQTLPLGFMV	SAC3D1	311	A6NKF1
SSPIVKNPFMSPLLA	LIPE	961	Q05469
KMPSLLFGSEIFPVS	PRR14L	1706	Q5THK1
FLAKAGPPASIVPLM	PAK4	571	O96013
NVPKMVFPQPESTLS	PHF20L1	246	A8MW92
PMKAVPTVAGARFPL	NR4A3	176	Q92570
MPKIVLNGVTVDFPF	RTEL1	1	Q9NZ71
GEFFPVPESILTSMK	WARS2	201	Q9UGM6
PQPLFKVGAMAAAPL	HHLA1	441	C9JL84
GFPFQLTTKPMVTSA	SENP2	71	Q9HC62
MVPEFVVPDLTGFKL	MRPL41	56	Q8IXM3
FISMVGLFSKPGLLP	TRMT2B	16	Q96GJ1
FNKMNLPGEVTFLPL	SMC3	576	Q9UQE7
LVKVDMSPGPFFSIT	SLC29A2	116	Q14542
ESLPFQNLPMEKSPL	PRUNE2	736	Q8WUY3
FPVLSPAFLSPMKNT	SPATA31C2	361	B4DYI2
IPAMGKTSFRIIFLP	TMEM131L	146	A2VDJ0
FPCLPLGSLMKTPDL	PRAMEF19	61	Q5SWL8
EGSPAMLPVQPAKLT	PMS2P2	261	O95744
MAFLETEPGKPFVSV	GMCL2	316	Q8NEA9
CSKPGELEMPLTPLF	SHOC1	256	Q5VXU9
KPFMLPPVAASSLRN	KITLG	181	P21583
SFPVLSPAFLSPMKN	SPATA31C1	366	P0DKV0
PTPALKGMFDFVVVL	SSTR2	286	P30874
FKPLMKNGTLTSFVP	POM121L2	196	Q96KW2
FGSIDPLKTTPMIAP	POM121L2	581	Q96KW2
LGDKPLTFPSPNSAM	SLCO4A1	6	Q96BD0
SMIPVSLGQVSFPKF	AHNAK2	4851	Q8IVF2
APKIPRLVQATPAFM	CLEC4F	31	Q8N1N0
PEFTMLLGALPKTFQ	CLASP1	1056	Q7Z460
APLAQISTPMFLPSA	RNF214	626	Q8ND24
FELPMNFPGLFKIVA	THEMIS	76	Q8N1K5
PSDVPPTMAVKFLGA	UCP3	6	P55916
TFSLMVTFPDVPLGI	TMEM175	126	Q9BSA9
FIPTSIFVKPQGRLM	TRAPPC11	1111	Q7Z392
LEPPGPLTLAMSQFL	USP16	251	Q9Y5T5
NKMNLPTPFGPITAR	RNPC3	191	Q96LT9
PQLPKAMFSELSNPE	SEC16A	1071	O15027
EAMTKLGFNVTLPPF	SSX8P	56	Q7RTT4
FLEFKVPGIPSGMET	SULT1A2	81	P50226
MLPVFFGESIKVNPE	RFLNA	86	Q6ZTI6
IFQKALSQTPMPAPE	SPOCD1	816	Q6ZMY3
FMPILGTNLNPEFIS	TNPO2	706	O14787
FTPVPSLLFNGIMAL	SLC7A7	356	Q9UM01
FPFLEMKIPSLGSGL	SULT1C4	86	O75897
MGEPFTVNPALTPAK	ZNF609	711	O15014
IQALPGPFLSMDPSA	WDFY4	1196	Q6ZS81
PPGLSAKMLSPEQTV	VWA5A	476	O00534
TINIPASPFMQKLGF	PBK	26	Q96KB5
FGLLQTFPFIMLTSP	TEX261	81	Q6UWH6
PLMTSLIGVPFPLNS	PIGN	326	O95427
TPLKPMFGNSEIVSP	TSHZ3	571	Q63HK5
MSLPLNPKPFLNGLT	SNRPF	1	P62306
PFQGGSFTLPLDVMK	MAP2	316	P11137
TPPNFPDALAMFSKL	UBALD2	71	Q8IYN6
SMPPLFPTVGKKDVN	ZGRF1	156	Q86YA3
FQKMTVTLNFLGSPP	TMEM130	256	Q8N3G9
MLASPEPKGLVPFTK	SCN7A	1	Q01118
FAAALDPPLFMAKPN	SCN7A	1541	Q01118
NLLPMVIFSDKVSPP	PIEZO1	2416	Q92508
KSQAMTLPPFLEFGV	USP40	1001	Q9NVE5
FSSNPISLPVPALEM	TTC39A	446	Q5SRH9
MFTLTTNGDLPKPIF	USP6	821	P35125
GDTKFSAVLVEPPPM	TRIM28	801	Q13263
MDFENLFSKPPNPAL	ZC3H8	1	Q8N5P1
GKFPSLPILSPALMD	AGL	1051	P35573
EVPVAAGKLPFSRMP	SPINK4	21	O60575
MFPLIGKTIIFDNFP	MYO3A	1	Q8NEV4
QMPKFDLGPLLSEPL	MYOZ1	241	Q9NP98