Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 GRHL3 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	9.62e-07	1412	27	11	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 GRHL3 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	1.33e-06	1459	27	11	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 GRHL3 ZNF99 ZNF433 ZNF287 ZNF254	2.70e-06	1244	27	10	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 GRHL3 ZNF99 ZNF433 ZNF287 ZNF254	3.27e-06	1271	27	10	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF729 ZNF721 HIVEP1 ZNF99 ZNF433	6.19e-05	320	27	5	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF729 ZNF721 HIVEP1 ZNF99 ZNF433	6.76e-05	326	27	5	GO:0001217
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF729 ZNF814 ZNF721 GRHL3 ZNF99 ZNF433	8.48e-05	560	27	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF729 ZNF814 ZNF721 GRHL3 ZNF99 ZNF433	9.00e-05	566	27	6	GO:0001216
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	ZNF729 ZNF721 ZNF99 HDGFL2 BANK1 ZNF433 ARHGAP26	6.97e-04	1160	27	7	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	ZNF729 ZNF721 ZNF99 HDGFL2 BANK1 ZNF433 ARHGAP26	1.74e-03	1356	27	7	GO:0060090
GeneOntologyBiologicalProcess	transposable element silencing	ZNF729 ZNF721 ZNF99	2.60e-05	46	26	3	GO:0010526
GeneOntologyBiologicalProcess	retrotransposition	ZNF729 ZNF721 ZNF99	2.96e-05	48	26	3	GO:0032197
GeneOntologyBiologicalProcess	transposition	ZNF729 ZNF721 ZNF99	3.35e-05	50	26	3	GO:0032196
Domain	KRAB	ZNF729 ZNF814 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	1.09e-09	358	27	9	PS50805
Domain	KRAB	ZNF729 ZNF814 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	1.09e-09	358	27	9	PF01352
Domain	zf-C2H2	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	1.29e-09	693	27	11	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	1.31e-09	694	27	11	IPR013087
Domain	KRAB	ZNF729 ZNF814 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	1.42e-09	369	27	9	SM00349
Domain	KRAB	ZNF729 ZNF814 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	1.46e-09	370	27	9	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	4.15e-09	775	27	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	4.26e-09	777	27	11	PS00028
Domain	Znf_C2H2-like	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	5.49e-09	796	27	11	IPR015880
Domain	Znf_C2H2	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	6.17e-09	805	27	11	IPR007087
Domain	ZnF_C2H2	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	6.41e-09	808	27	11	SM00355
Domain	-	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF254	1.82e-08	679	27	10	3.30.160.60
Domain	zf-C2H2_6	ZNF729 ZNF814 ZNF721 ZNF30 ZNF99 ZNF582 ZNF433	2.36e-07	314	27	7	PF13912
Domain	HECT	AREL1 G2E3	6.91e-04	27	27	2	PF00632
Domain	HECTc	AREL1 G2E3	6.91e-04	27	27	2	SM00119
Domain	HECT_dom	AREL1 G2E3	6.91e-04	27	27	2	IPR000569
Domain	HECT	AREL1 G2E3	6.91e-04	27	27	2	PS50237
Domain	SH3_domain	MPP1 ZNF582 ARHGAP26	3.83e-03	220	27	3	IPR001452
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF729 ZNF721 ZNF30 GLS2 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	1.72e-06	1387	18	10	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF729 ZNF814 ZNF721 GLS2 ZNF99 ZNF433 ZNF254	2.60e-05	768	18	7	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF729 ZNF814 ZNF721 GLS2 ZNF99 ZNF433 ZNF254	1.61e-04	1022	18	7	MM15436
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF814 ZNF721 ZNF99 ZNF287	3.55e-10	49	27	5	9630514
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF721 ZNF99 ZNF254	3.91e-10	15	27	4	15885501
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF721 ZNF99 ZNF254	6.75e-09	29	27	4	14563677
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF721 ZNF99	4.99e-08	10	27	3	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF721 ZNF99	6.86e-08	11	27	3	15469996
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF721 ZNF99	1.19e-07	13	27	3	19850934
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MPP1 ZNF99 AP3M1 HDGFL2 DHX37	3.64e-05	497	27	5	36774506
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF814 ZNF254	1.09e-04	20	27	2	2542606
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF814 ZNF254	1.09e-04	20	27	2	7479878
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TMEM131L AREL1 G2E3 AP3M1 ARHGAP26 ZNF254	1.53e-04	1084	27	6	11544199
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF729 ZNF721 HIVEP1 ZNF99 ZNF254	3.53e-04	808	27	5	20412781
Cytoband	19p12	ZNF729 ZNF99 ZNF254	2.06e-05	90	27	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF99 ZNF254	5.11e-05	122	27	3	chr19p12
Cytoband	19q13.43	ZNF814 ZNF582	1.21e-03	87	27	2	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr14q22	CDKL1 FBXO34	1.41e-03	94	27	2	chr14q22
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF814 ZNF30 ZNF285 ZNF582	4.93e-03	1192	27	4	chr19q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZNF814 ZNF721 HIVEP1 ZNF30 ZNF285 ZNF99 ZNF582 ZNF433 ZNF287 ZNF254	8.81e-11	718	21	11	28
GeneFamily	Ankyrin repeat domain containing	GLS2 BANK1	3.17e-02	242	21	2	403
Coexpression	TERAO_AOX4_TARGETS_SKIN_DN	ZNF729 ZNF721 ZNF99	3.14e-06	28	27	3	MM925
Coexpression	DURAND_STROMA_NS_UP	ZNF729 ZNF721 ZNF99 ARHGAP26	4.47e-05	194	27	4	MM962
Disease	platelet measurement	TMEM131L BANK1 FBXO34	1.82e-03	315	23	3	EFO_0005036
Disease	eosinophil measurement	TMEM131L ITGB8	3.19e-03	108	23	2	EFO_0803540
Disease	lipoprotein A measurement	GLS2 SYTL3	3.43e-03	112	23	2	EFO_0006925

Protein segments in the cluster

Peptide	Gene	Start	Entry
KIKYYPTAKAKECLF	BANK1	276	Q8NDB2
PCKQCKKKYVKGDVS	FBXO34	631	Q9NWN3
GEKYKPFKGVKYVTK	AP3M1	396	Q9Y2T2
YYLKEKKCFPKGVDM	GLS2	326	Q9UI32
KDLFPYDKCKDKYGK	HDGFL2	56	Q7Z4V5
YDKCKDKYGKPNKRK	HDGFL2	61	Q7Z4V5
IKLGKVYGKYCEKDD	ITGB8	536	P26012
DDCPNKYGEKKTKEK	G2E3	21	Q7L622
PEENIYKVYKKCKRG	GRHL3	551	Q8TE85
LPALDNKKYYCDTKK	CDKL1	336	Q00532
KVKKPKKVYCYVSPK	AREL1	346	O15033
SCSPFGKKKKYKDKY	MPP1	241	Q00013
GIKYVVDCGKVKKRY	DHX37	631	Q8IY37
KNLAYGEEKKKKCNP	SYTL3	331	Q4VX76
GEEKKKKCNPYVKTY	SYTL3	336	Q4VX76
EGYYQKPEKKCVDKF	TMEM131L	1286	A2VDJ0
KKKYDKETEKYCGIL	ARHGAP26	131	Q9UNA1
VGEKPYKYEKCGKAF	ZNF30	171	P17039
DKPYKYKKCGKAFNI	ZNF99	226	A8MXY4
KPYKCNVCGKKFRKY	ZNF287	366	Q9HBT7
PKDLKSGKQKKYCFL	REXO5	631	Q96IC2
TGKKPYKCKQCGKVI	ZNF721	456	Q8TF20
EKPYKCKECGKAFKY	ZNF582	196	Q96NG8
EYGQKPYKCKYCKKP	ZNF433	136	Q8N7K0
KDQKPKKQGKYICEY	HIVEP1	396	P15822
YQKVSSGDKPYKCKE	ZNF285	306	Q96NJ3
KPYKCEEYNKSPKQL	ZNF254	236	O75437
KPYKCEKCGKLFNKK	ZNF814	826	B7Z6K7
TEDKPYKYKKCGNAF	ZNF729	231	A6NN14