Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	exopeptidase activity	DPEP2 FOLH1B SCPEP1 MMP14 MMP15	8.50e-05	110	81	5	GO:0008238
GeneOntologyMolecularFunction	metalloexopeptidase activity	DPEP2 FOLH1B MMP14 MMP15	1.88e-04	70	81	4	GO:0008235
Domain	DUF3377	MMP14 MMP15	1.00e-04	4	77	2	PF11857
Domain	Pept_M10A_metallopeptidase_C	MMP14 MMP15	1.00e-04	4	77	2	IPR021805
Domain	Pept_M10A_Zn_BS	MMP14 MMP15	1.70e-03	15	77	2	IPR021158
Domain	Hemopexin_CS	MMP14 MMP15	2.19e-03	17	77	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP14 MMP15	2.46e-03	18	77	2	IPR016293
Domain	KAZAL_1	FSTL3 FSTL4	2.46e-03	18	77	2	PS00282
Domain	PG_binding_1	MMP14 MMP15	3.04e-03	20	77	2	PF01471
Domain	Peptidoglycan-bd-like	MMP14 MMP15	3.04e-03	20	77	2	IPR002477
Domain	Kazal_1	FSTL3 FSTL4	3.67e-03	22	77	2	PF00050
Domain	Quino_amine_DH_bsu	UTP4 FSTL4	3.67e-03	22	77	2	IPR011044
Domain	Hemopexin-like_dom	MMP14 MMP15	4.01e-03	23	77	2	IPR000585
Domain	Hemopexin-like_repeat	MMP14 MMP15	4.01e-03	23	77	2	IPR018487
Domain	M10A_MMP	MMP14 MMP15	4.01e-03	23	77	2	IPR033739
Domain	Hemopexin	MMP14 MMP15	4.01e-03	23	77	2	PF00045
Domain	HEMOPEXIN	MMP14 MMP15	4.01e-03	23	77	2	PS00024
Domain	-	MMP14 MMP15	4.01e-03	23	77	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP14 MMP15	4.01e-03	23	77	2	PS51642
Domain	HX	MMP14 MMP15	4.01e-03	23	77	2	SM00120
Domain	Pept_M10A	MMP14 MMP15	4.01e-03	23	77	2	IPR021190
Domain	Peptidase_M10	MMP14 MMP15	4.37e-03	24	77	2	PF00413
Domain	ZnMc	MMP14 MMP15	6.34e-03	29	77	2	SM00235
Domain	Peptidase_Metallo	MMP14 MMP15	6.34e-03	29	77	2	IPR006026
Domain	Ig_I-set	HMCN2 FSTL4 FGFR3 ROBO3	7.88e-03	190	77	4	IPR013098
Domain	I-set	HMCN2 FSTL4 FGFR3 ROBO3	7.88e-03	190	77	4	PF07679
Pubmed	cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment.	MMP14 MMP15	5.63e-06	2	83	2	7649159
Pubmed	Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis.	MUC16 MUC5AC	5.63e-06	2	83	2	18782111
Pubmed	ZNF674: a new kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation.	ZNF674 KRBOX4	5.63e-06	2	83	2	16385466
Pubmed	Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers.	MUC16 MUC5AC	5.63e-06	2	83	2	22220206
Pubmed	USP36 SUMOylates Las1L and Promotes Its Function in Pre-Ribosomal RNA ITS2 Processing.	USP36 LAS1L	5.63e-06	2	83	2	39356143
Pubmed	Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product.	MMP14 MMP15	5.63e-06	2	83	2	9037199
Pubmed	Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium.	MUC16 MMP14	5.63e-06	2	83	2	25205731
Pubmed	A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B.	ATG4B ULK1	5.63e-06	2	83	2	28821708
Pubmed	Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases.	MMP14 MMP15	5.63e-06	2	83	2	9461298
Pubmed	Tumour Suppressor Neuron Navigator 3 and Matrix Metalloproteinase 14 are Co-expressed in Most Melanomas but Downregulated in Thick Tumours.	NAV3 MMP14	5.63e-06	2	83	2	36883877
Pubmed	MMP-14 Exhibits Greater Expression, Content and Activity Compared to MMP-15 in Human Renal Carcinoma.	MMP14 MMP15	5.63e-06	2	83	2	39125675
Pubmed	Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer.	MUC16 MUC5AC	5.63e-06	2	83	2	24722639
Pubmed	Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjögren's syndrome-associated dry eyes.	MUC16 MUC5AC	1.69e-05	3	83	2	33232357
Pubmed	Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma.	SCPEP1 KHSRP	1.69e-05	3	83	2	21935400
Pubmed	An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution.	FSTL3 FSTL4	1.69e-05	3	83	2	15527507
Pubmed	Dominative role of MMP-14 over MMP-15 in human urinary bladder carcinoma on the basis of its enhanced specific activity.	MMP14 MMP15	1.69e-05	3	83	2	32049862
Pubmed	Prognostic value of membrane type 1 and 2 matrix metalloproteinase expression and gelatinase A activity in bladder cancer.	MMP14 MMP15	1.69e-05	3	83	2	20586027
Pubmed	A cancer cell metalloprotease triad regulates the basement membrane transmigration program.	MMP14 MMP15	1.69e-05	3	83	2	16983145
Pubmed	Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization.	MMP14 MMP15	1.69e-05	3	83	2	9119382
Pubmed	Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1.	MMP14 MMP15	1.69e-05	3	83	2	19915148
Pubmed	Ezh2 represses the basal cell lineage during lung endoderm development.	POU3F3 FUT4 MUC5AC	2.56e-05	24	83	3	25516972
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ATXN2 WDR33 POLR2A SRP72 PLEC LAS1L THOC3	3.02e-05	370	83	7	22922362
Pubmed	Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.	MMP14 MMP15	3.37e-05	4	83	2	27633994
Pubmed	Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice.	POLR2A FUT4	3.37e-05	4	83	2	17567665
Pubmed	Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland.	MMP14 MMP15	3.37e-05	4	83	2	15895410
Pubmed	Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).	MMP14 MMP15	3.37e-05	4	83	2	35062057
Pubmed	CircRNA circUSP36 impairs the stability of NEDD4L mRNA through recruiting PTBP1 to enhance ULK1-mediated autophagic granulosa cell death.	USP36 ULK1	3.37e-05	4	83	2	35964538
Pubmed	Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.	COL16A1 ITGA2	3.37e-05	4	83	2	16754661
Pubmed	mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.	MMP14 MMP15	5.60e-05	5	83	2	12661033
Pubmed	MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.	MMP14 MMP15	5.60e-05	5	83	2	29196321
Pubmed	Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.	ITGA2 MMP14 MMP15	6.18e-05	32	83	3	23154389
Pubmed	A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.	SETD1B ATXN2 DSTYK	7.43e-05	34	83	3	24026423
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC16 MUC5AC	8.39e-05	6	83	2	19110483
Pubmed	Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.	MMP14 MMP15	8.39e-05	6	83	2	30269950
Pubmed	The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.	MMP14 MMP15	8.39e-05	6	83	2	14645246
Pubmed	Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain.	EOMES FGFR3	8.39e-05	6	83	2	29132503
Pubmed	Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly.	EOMES FGFR3	8.39e-05	6	83	2	25916825
Pubmed	Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II.	POLR2A IFI6	8.39e-05	6	83	2	15502823
Pubmed	Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.	COL16A1 FGFR3 ITGA2	1.13e-04	39	83	3	25859222
Pubmed	Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.	EOMES POU3F3	1.17e-04	7	83	2	17959791
Pubmed	Membrane-type matrix metalloproteinases: Their functions and regulations.	MMP14 MMP15	1.17e-04	7	83	2	25794647
Pubmed	Fgfr3 regulates development of the caudal telencephalon.	EOMES FGFR3	1.56e-04	8	83	2	21491541
Pubmed	3' UTR-dependent, miR-92-mediated restriction of Tis21 expression maintains asymmetric neural stem cell division to ensure proper neocortex size.	EOMES POU3F3	1.56e-04	8	83	2	24726360
Pubmed	Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.	MMP14 MMP15	1.56e-04	8	83	2	31600777
Pubmed	POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex.	EOMES POU3F3	1.56e-04	8	83	2	22892427
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	ATXN2 WDR33 POLR2A BCL9 KHSRP	1.88e-04	220	83	5	24550385
Pubmed	Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.	ATG4B ULK1	2.00e-04	9	83	2	26649827
Pubmed	Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development.	MMP14 MMP15	2.00e-04	9	83	2	16113801
Pubmed	FGF Signaling Directs the Cell Fate Switch from Neurons to Astrocytes in the Developing Mouse Cerebral Cortex.	EOMES FGFR3	2.00e-04	9	83	2	31175212
Pubmed	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.	SETD1B POLR2A	2.50e-04	10	83	2	17998332
Pubmed	Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex.	EOMES FGFR3	2.50e-04	10	83	2	19192266
Pubmed	Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium.	EOMES FGFR3	2.50e-04	10	83	2	11739261
Pubmed	Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone.	EOMES POU3F3	2.50e-04	10	83	2	18033766
Pubmed	Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.	MMP14 MMP15	3.05e-04	11	83	2	10949161
Pubmed	USP9X-mediated deubiquitination of B-cell CLL/lymphoma 9 potentiates Wnt signaling and promotes breast carcinogenesis.	PLEC BCL9	3.05e-04	11	83	2	31073027
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	BCL2L12 SETD1B POLR2A ULK1 FUT4 MMP14 MMP15 KHSRP	3.58e-04	730	83	8	34857952
Pubmed	Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.	OAS3 PLEC	3.66e-04	12	83	2	35850054
Pubmed	The roles of FGF signaling in germ cell migration in the mouse.	FGFR3 FUT4	3.66e-04	12	83	2	16291796
Pubmed	Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.	EOMES POU3F3	3.66e-04	12	83	2	20823249
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	USP36 SMG8 ATG4B SETD1B UTP4 POLR2A OAS3 PLEC LAS1L MMP14 KHSRP	3.67e-04	1353	83	11	29467282
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	USP36 UTP4 POLR2A LAS1L KHSRP	3.99e-04	259	83	5	30404004
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	PASK VPS13D UTP4 NAV3 PLEC MUC5AC KHSRP	4.07e-04	564	83	7	21565611
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	RBMXL3 ATXN2 WDR33 SRP72 OAS3 CLINT1 PLEC LAS1L THOC3 MUC5AC KHSRP	4.10e-04	1371	83	11	36244648
Pubmed	The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway.	EOMES POU3F3	4.31e-04	13	83	2	25698753
Pubmed	Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function.	EOMES POU3F3	4.31e-04	13	83	2	18596172
Pubmed	Progenitor cell diversity in the developing mouse neocortex.	EOMES POU3F3	4.31e-04	13	83	2	33649223
Pubmed	Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.	EOMES POU3F3	4.31e-04	13	83	2	19403657
Pubmed	High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis.	EOMES FUT4	4.31e-04	13	83	2	31699896
Pubmed	Appropriate Bmp7 levels are required for the differentiation of midline guidepost cells involved in corpus callosum formation.	EOMES POU3F3	4.31e-04	13	83	2	21485009
Pubmed	Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.	EOMES POU3F3	4.31e-04	13	83	2	22645310
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	USP36 ATXN2 WDR33 POLR2A SRP72 CLINT1 LAS1L THOC3 KHSRP	4.53e-04	954	83	9	36373674
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	ATXN2 WDR33 UTP4 PLEC	4.93e-04	152	83	4	16009940
Pubmed	FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.	ATG4B ULK1	5.03e-04	14	83	2	25126726
Pubmed	Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors.	EOMES POU3F3	5.03e-04	14	83	2	20460369
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	MMP14 MMP15	5.03e-04	14	83	2	20858856
Pubmed	Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia.	TIE1 ACHE	5.03e-04	14	83	2	10981960
Pubmed	Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex.	EOMES POU3F3	5.79e-04	15	83	2	18940587
Pubmed	Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes.	EOMES POU3F3	5.79e-04	15	83	2	22723706
Pubmed	Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.	EOMES POU3F3	5.79e-04	15	83	2	28552558
Pubmed	COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.	EOMES FGFR3	5.79e-04	15	83	2	18165280
Pubmed	Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program.	SETD1B BCL9	5.79e-04	15	83	2	28619824
Pubmed	SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations.	POLR2A MUS81	5.79e-04	15	83	2	32398829
Pubmed	Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality.	EOMES FGFR3	5.79e-04	15	83	2	33116259
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	SETD1B HMCN2 ATXN2 POLR2A MUS81	5.96e-04	283	83	5	18854154
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP14 MMP15	6.61e-04	16	83	2	10949577
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP14 MMP15	6.61e-04	16	83	2	37701782
Pubmed	Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse.	FUT4 MMP14	6.61e-04	16	83	2	27435625
Pubmed	Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development.	POLR2A FGFR3	7.48e-04	17	83	2	21494559
Pubmed	miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex.	EOMES POU3F3	7.48e-04	17	83	2	18997113
Pubmed	mTOR regulates brain morphogenesis by mediating GSK3 signaling.	EOMES POU3F3	7.48e-04	17	83	2	25273085
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC16 MUC5AC	8.40e-04	18	83	2	18834073
Pubmed	Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells.	EOMES FUT4	8.40e-04	18	83	2	28728023
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	EOMES POLR2A LAS1L KHSRP	8.71e-04	177	83	4	26206133
Pubmed	Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits.	EOMES POU3F3	9.37e-04	19	83	2	20410112
Pubmed	Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.	XIRP1 GORASP1	9.37e-04	19	83	2	24564958
Pubmed	MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.	EOMES POU3F3	9.37e-04	19	83	2	19666823
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PASK ATG4B ATXN2 WDR33 DSTYK POLR2A ULK1 LAS1L QRICH2 KHSRP	9.58e-04	1284	83	10	17353931
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SETD1B ATXN2 POLR2A NAV3 SHISA7 KHSRP	9.78e-04	475	83	6	31040226
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	USP36 SRP72 CLINT1 PLEC KHSRP KIF1C	9.99e-04	477	83	6	31300519
Pubmed	A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus.	EOMES ACHE	1.04e-03	20	83	2	17916349
Interaction	ZNF721 interactions	TNIP2 PLEC ZNF467	5.36e-06	9	82	3	int:ZNF721
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HMCN2 FSTL4 FGFR3 ROBO3	9.40e-04	161	49	4	593
GeneFamily	CD molecules\|Mucins	MUC16 MUC5AC	1.46e-03	21	49	2	648
GeneFamily	Immunoglobulin like domain containing	HMCN2 TIE1 FSTL4 ROBO3	1.83e-03	193	49	4	594
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP14 MMP15	1.91e-03	24	49	2	891
GeneFamily	Autophagy related	ATG4B ULK1	3.60e-03	33	49	2	1022
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	TIE1 FGFR3	5.26e-03	40	49	2	321
Coexpression	GSE5099_UNSTIM_VS_MCSF_TREATED_MONOCYTE_DAY7_DN	USP36 BCL2L12 TNIP2 RNF112 POLR2A PLEC ABHD12	3.45e-06	200	83	7	M6585
Drug	copper(II) sulfate pentahydrate; Up 200; 100uM; PC3; HG-U133A	ATXN2 DSTYK SRP72 ULK1 BCL9 LRRC41 KIF1C	7.41e-06	198	82	7	459_UP
Drug	Norfloxacin [70458-96-7]; Up 200; 12.6uM; PC3; HT_HG-U133A	VPS13D SETD1B DSTYK DEPP1 ITGA2 ZNF467 MMP14	7.41e-06	198	82	7	2090_UP
Drug	Dimenhydrinate [523-87-5]; Up 200; 8.6uM; MCF7; HT_HG-U133A	VPS13D FSTL3 DSTYK OAS3 ULK1 FUT4 LRRC41	7.41e-06	198	82	7	7431_UP
Drug	(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; MCF7; HT_HG-U133A	PASK VPS13D WDR33 OAS3 FUT4 MMP14 LRRC41	7.66e-06	199	82	7	2855_DN
Drug	CID10417357	ACHE ITGA2	1.28e-05	2	82	2	CID010417357
Drug	D05540	TIE1 ITGA2	3.84e-05	3	82	2	CID000065431
Drug	NSC 36664	ACHE ITGA2	3.84e-05	3	82	2	CID000022645
Drug	nostocarboline	ACHE ITGA2	3.84e-05	3	82	2	CID005326150
Drug	NSC628058	ACHE ITGA2	3.84e-05	3	82	2	CID000431073
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	MBTPS1 SETD1B JADE2 NAV3 PLEC LRRC41	3.96e-05	174	82	6	5940_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	SETD1B FSTL3 JADE2 POLR2A MMP14 LRRC41	4.49e-05	178	82	6	4184_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	PASK FSTL3 POLR2A FGFR3 ULK1 BCL9	5.57e-05	185	82	6	5585_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	USP36 PASK FSTL3 FGFR3 ULK1 MMP15	7.04e-05	193	82	6	5566_DN
Drug	NS-398; Down 200; 10uM; PC3; HT_HG-U133A	VPS13D NAV3 PLEC FUT4 NACAD KHSRP	7.45e-05	195	82	6	6892_DN
Drug	Mefloquine hydrochloride [51773-92-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A	VPS13D DSTYK PLEC ROBO3 BCL9 LRRC41	7.67e-05	196	82	6	2210_DN
Drug	Lovastatin [75330-75-5]; Down 200; 9.8uM; MCF7; HT_HG-U133A	VPS13D DSTYK OAS3 ROBO3 MMP15 IFI6	7.67e-05	196	82	6	4978_DN
Drug	Solasodine [126-17-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	ZNF134 FSTL3 JADE2 OAS3 FUT4 IFI6	7.89e-05	197	82	6	3924_DN
Drug	Chlorthalidone [77-36-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	PASK VPS13D OAS3 FUT4 MMP14 KIF1C	8.11e-05	198	82	6	3198_DN
Drug	HA-1077 dihydrochloride; Down 200; 10uM; PC3; HG-U133A	PASK SETD1B ATXN2 DSTYK BCL9 MMP14	8.11e-05	198	82	6	436_DN
Drug	Flunixin meglumine [42461-84-7]; Down 200; 8.2uM; MCF7; HT_HG-U133A	WDR33 OAS3 FUT4 MMP15 IFI6 KIF1C	8.11e-05	198	82	6	4735_DN
Drug	Nifenazone [2139-47-1]; Down 200; 13uM; HL60; HG-U133A	VPS13D SETD1B POLR2A NAV3 ZNF467 MMP14	8.34e-05	199	82	6	1439_DN
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	USP36 PASK POLR2A FGFR3 FUT4 MMP15	8.34e-05	199	82	6	7439_UP
Drug	Papaverine hydrochloride [61-25-6]; Down 200; 10.6uM; PC3; HT_HG-U133A	PASK VPS13D WDR33 FUT4 MMP14 KHSRP	8.34e-05	199	82	6	5769_DN
Disease	keratoconjunctivitis (is_marker_for)	MUC16 MUC5AC	1.91e-05	3	75	2	DOID:9368 (is_marker_for)
Disease	dry eye syndrome (is_marker_for)	MUC16 MUC5AC	2.83e-04	10	75	2	DOID:10140 (is_marker_for)
Disease	Tremor	ACHE ABHD12	3.45e-04	11	75	2	C0040822
Disease	asthma, body mass index	USP36 COL16A1	5.69e-04	14	75	2	EFO_0004340, MONDO_0004979
Disease	Generalized hypotonia	POLR2A POU3F3	6.55e-04	15	75	2	C1858120
Disease	Sjogren's syndrome (is_marker_for)	MUC16 MUC5AC	1.70e-03	24	75	2	DOID:12894 (is_marker_for)
Disease	cortical thickness	VPS13D ATXN2 UTP4 NAV3 MUS81 POU3F3 FGFR3 PLEC ABHD12	2.02e-03	1113	75	9	EFO_0004840

Protein segments in the cluster

Peptide	Gene	Start	Entry
GAPNGPWATVGMGEA	ACHE	261	P22303
DPTFPAMAGWGGRGS	EOMES	566	O95936
FTWMDGPPHGGLGTR	LINC00242	81	Q5T6M2
FSGMPGAPGLWMGSS	COL16A1	886	Q07092
TGPSAGLWGPHRQMD	DEPP1	126	Q9NTK1
GGARSKWAAPDPMGG	AFDN-DT	61	Q9Y6Z5
AGSKWAALGPMGGTG	AFDN-DT	126	Q9Y6Z5
MSLPPGLLGNSWGEG	GSDMD	421	P57764
RWGPGPGASMAGSEE	BCL2L12	76	Q9HB09
IGGTGPTSDTGWGCM	ATG4B	61	Q9Y4P1
WEGIPESPRGSFMGS	MMP14	456	P50281
WPGMDQSGLAQPGRD	QRICH2	456	Q9H0J4
RGWGDSVGTPSERGM	ABHD12	206	Q8N2K0
EMTTSMGRGPGGVSW	MUC16	7661	Q8WXI7
NPSTLGGRGGWIMRS	OR1F12P	316	Q8NHA8
MGVSGPSGSDLWAGA	PASK	576	Q96RG2
ATNDDPWGPSGQLMG	CLINT1	31	Q14677
SPGESGAWDIPGGIM	MBTPS1	976	Q14703
MGWVTTQSPEGGDPS	GK3P	511	Q14409
MGAPWGSPTAAAGGR	FUT4	126	P22083
GEPQGSWGSMTGVIN	HMCN2	4391	Q8NDA2
WGSGRQNSPRMGQPG	ATXN2	506	Q99700
MGSDPSAPGRPGWTG	MMP15	1	P51511
TMLGEGSQPDWPGGS	JADE2	121	Q9NQC1
PGSRGPGWGRADTAM	PDZD7	356	Q9H5P4
TGSWRRGMSAQGGAP	NAV3	986	Q8IVL0
MGGSAPPDSSWRGSL	FOLH1B	1	Q9HBA9
QHRESWPGMGSGEAP	KIF1C	986	O43896
MSWESGAGPGLGSQG	LAS1L	1	Q9Y4W2
VPGSNSWAPPMGAGS	KREMEN1	371	Q96MU8
PWMDVSRPGRGTDSG	MUC5AC	1391	P98088
GSPWSGFPENRMGDV	ITGA2	66	P17301
MEGDGVPWGSEPVSG	DSTYK	1	Q6XUX3
PSNMWGGQGLLGASV	GORASP1	86	Q9BQQ3
SWKPGMGGDPRGVGA	PRR35	161	P0CG20
MGWVTSQSPEGGDPS	GK2	511	Q14410
SMGSGNPAPGGVCWL	FSTL3	26	O95633
WAPGGTEPFSDGINM	BCL9	526	O00512
LGWMDPGTSRGPDVG	FSTL4	21	Q6MZW2
MSWSAILNGGGVPAG	IFI6	76	P09912
MQPSGLEGPGTFGRW	DPEP2	1	Q9H4A9
GPGEESWMADGGTPV	KRBOX4	61	Q5JUW0
GGPMGPTVWVKDGTG	FGFR3	66	P22607
AEMPGQGPGSDWTER	FAM216A	16	Q8WUB2
PWSGSAVGMAGSPQQ	POU3F3	121	P20264
MGSPWNGSDGPEGAR	MLNR	1	O43193
MDSLWGPGAGSHPFG	POM121L1P	1	Q3SYA9
AGAGSMGSPGATTGW	P2RX6	6	O15547
RGMGDPVQSWKGPGL	OAS3	331	Q9Y6K5
PAAAGPLGPWGSMSS	MAPK1IP1L	136	Q8NDC0
GSMSSGPWAPGMGGQ	MAPK1IP1L	146	Q8NDC0
AWMGSESPGGSPTEG	SMG8	16	Q8ND04
GQGNWGPPGGEMTFS	KHSRP	416	Q92945
GGPIWSMAASPSGSQ	UTP4	101	Q969X6
SPSGGSGWGSPQRNG	SRRM3	301	A6NNA2
ILTMSAGFWQPGPGG	LRRC41	246	Q15345
VMWLQGGPGGSSTGF	SCPEP1	71	Q9HB40
GGDMGNWTSLPTTPF	SLC22A23	146	A1A5C7
PQPAWMSDAGGGGGT	SHISA7	486	A6NL88
SMELGGRPTFGWSPE	SETD1B	461	Q9UPS6
MASGGSGGVSVPALW	SRP72	1	O76094
MFESSPGGNLGWEPD	PI4KAP2	466	A4QPH2
AMPQARGCPGGTSWE	SPATA25	66	Q9BR10
MSRDPGSGGWEEAPR	TNIP2	1	Q8NFZ5
ATPPVWERGGAGGMQ	ZNF414	51	Q96IQ9
IGGSGMPGKAPAVWG	RBMXL3	216	Q8N7X1
GWMGRTGPGFTSPDE	RNF112	436	Q9ULX5
GPEAGSGWPGLLMSC	RNF208	6	Q9H0X6
EGGEGAWGPPTLMTT	TIE1	526	P35590
SAPGRTWQGNGEMTP	ROBO3	1226	Q96MS0
GGISPAMTPWNQGAT	POLR2A	1511	P24928
WSPSVGSGMTPGAAG	POLR2A	1531	P24928
SALGQSGPGSMAPWC	THOC3	11	Q96J01
SGPGSMAPWCSVSSG	THOC3	16	Q96J01
IPGGGSHGGSTMSLW	PLEC	3711	Q15149
MGQPWAAGSTDGAPA	ZDHHC24	1	Q6UX98
MASGAGGSWGRSPPQ	PRR29	1	P0C7W0
SNWGRGSNMNSGPPR	WDR33	1311	Q9C0J8
GPGDESWMADGGTPV	ZNF674	61	Q2M3X9
PGREEPGGCTQMAWG	XIRP1	1191	Q702N8
SSGMELSWGQSPGQP	TEX19	76	Q8NA77
GWSGTPSPQGAEMRG	ULK1	516	O75385
MTLVTAGGAWTGPGC	ZNF134	1	P52741
PGALSGLALSGWGPM	ZNF467	141	Q7Z7K2
PSANGWCPGDRMGLS	USP36	996	Q9P275
GIHPEGMPGWCQGFS	VPS13D	3341	Q5THJ4
DFPSGWGLSPQGSMV	NACAD	246	O15069
RPWGTPGNPESGAMT	MUS81	431	Q96NY9