Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessaxon guidance

PCDHAC2 SEMA5A MYCBP2 NOTCH1 NOTCH3

1.33e-05285235GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

PCDHAC2 SEMA5A MYCBP2 NOTCH1 NOTCH3

1.36e-05286235GO:0097485
GeneOntologyBiologicalProcessaxonogenesis

PCDHAC2 SEMA5A MYCBP2 NOTCH1 WNT7A NOTCH3

2.82e-05566236GO:0007409
GeneOntologyBiologicalProcessaxon development

PCDHAC2 SEMA5A MYCBP2 NOTCH1 WNT7A NOTCH3

5.70e-05642236GO:0061564
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

PCDHAC2 SEMA5A MYCBP2 NOTCH1 WNT7A NOTCH3

1.33e-04748236GO:0048667
GeneOntologyBiologicalProcesssomatic stem cell division

NOTCH1 WNT7A

1.60e-0417232GO:0048103
GeneOntologyBiologicalProcessneuron projection morphogenesis

PCDHAC2 SEMA5A MYCBP2 NOTCH1 WNT7A NOTCH3

1.94e-04802236GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

PCDHAC2 SEMA5A MYCBP2 NOTCH1 WNT7A NOTCH3

2.17e-04819236GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

PCDHAC2 SEMA5A MYCBP2 NOTCH1 WNT7A NOTCH3

2.28e-04826236GO:0048858
GeneOntologyBiologicalProcessregulation of cell-cell adhesion mediated by cadherin

ADAM19 NOTCH1

2.47e-0421232GO:2000047
GeneOntologyBiologicalProcessregulation of endothelial cell chemotaxis

SEMA5A NOTCH1

3.80e-0426232GO:2001026
GeneOntologyBiologicalProcessblood vessel development

PCSK5 SEMA5A CHM NOTCH1 WNT7A NOTCH3

4.29e-04929236GO:0001568
GeneOntologyBiologicalProcessglomerulus vasculature development

NOTCH1 NOTCH3

5.08e-0430232GO:0072012
GeneOntologyBiologicalProcessvasculature development

PCSK5 SEMA5A CHM NOTCH1 WNT7A NOTCH3

5.37e-04969236GO:0001944
GeneOntologyBiologicalProcesskidney vasculature development

NOTCH1 NOTCH3

5.42e-0431232GO:0061440
GeneOntologyBiologicalProcessrenal system vasculature development

NOTCH1 NOTCH3

5.42e-0431232GO:0061437
GeneOntologyBiologicalProcessendothelial cell chemotaxis

SEMA5A NOTCH1

6.92e-0435232GO:0035767
GeneOntologyBiologicalProcessembryonic hindlimb morphogenesis

NOTCH1 WNT7A

6.92e-0435232GO:0035116
GeneOntologyBiologicalProcessskin development

KRT81 NOTCH1 WNT7A KRT86

7.10e-04373234GO:0043588
GeneOntologyBiologicalProcesscirculatory system development

PCSK5 SEMA5A ADAM19 CHM NOTCH1 WNT7A NOTCH3

7.28e-041442237GO:0072359
GeneOntologyBiologicalProcessnegative regulation of neurogenesis

SEMA5A NOTCH1 WNT7A

9.08e-04173233GO:0050768
GeneOntologyBiologicalProcessnegative regulation of nervous system development

SEMA5A NOTCH1 WNT7A

1.08e-03184233GO:0051961
GeneOntologyBiologicalProcesspositive regulation of nervous system development

SEMA5A NOTCH1 WNT7A NCAN

1.08e-03418234GO:0051962
GeneOntologyBiologicalProcesspositive regulation of neuroblast proliferation

NOTCH1 NCAN

1.09e-0344232GO:0002052
GeneOntologyBiologicalProcessappendage morphogenesis

PCSK5 NOTCH1 WNT7A

1.10e-03185233GO:0035107
GeneOntologyBiologicalProcesslimb morphogenesis

PCSK5 NOTCH1 WNT7A

1.10e-03185233GO:0035108
GeneOntologyBiologicalProcesskeratinocyte differentiation

KRT81 NOTCH1 KRT86

1.17e-03189233GO:0030216
GeneOntologyBiologicalProcesshindlimb morphogenesis

NOTCH1 WNT7A

1.35e-0349232GO:0035137
GeneOntologyBiologicalProcessstem cell division

NOTCH1 WNT7A

1.35e-0349232GO:0017145
GeneOntologyBiologicalProcesscell-cell adhesion mediated by cadherin

ADAM19 NOTCH1

1.41e-0350232GO:0044331
GeneOntologyCellularComponentGolgi lumen

PCSK5 WNT7A NCAN

3.29e-04109263GO:0005796
HumanPhenoPerifollicular hyperkeratosis

KRT81 KRT86

2.08e-054102HP:0007468
HumanPhenoAbnormal perifollicular morphology

KRT81 KRT86

5.18e-056102HP:0031285
HumanPhenoAbnormal enzyme activity in muscle tissue

AGL NADK2

9.65e-058102HP:0034526
DomainEGF-like_dom

PCSK5 ADAM30 ADAM19 NOTCH1 NOTCH3 NCAN

9.73e-07249266IPR000742
DomainDUF3454

NOTCH1 NOTCH3

5.59e-063262PF11936
DomainDUF3454_notch

NOTCH1 NOTCH3

5.59e-063262IPR024600
DomainDUF3454

NOTCH1 NOTCH3

5.59e-063262SM01334
DomainNOD

NOTCH1 NOTCH3

1.12e-054262PF06816
DomainNotch

NOTCH1 NOTCH3

1.12e-054262IPR008297
DomainNODP

NOTCH1 NOTCH3

1.12e-054262PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH3

1.12e-054262IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH3

1.12e-054262IPR010660
DomainNOD

NOTCH1 NOTCH3

1.12e-054262SM01338
DomainNODP

NOTCH1 NOTCH3

1.12e-054262SM01339
DomainEGF_3

ADAM30 ADAM19 NOTCH1 NOTCH3 NCAN

1.60e-05235265PS50026
DomainLNR

NOTCH1 NOTCH3

1.86e-055262PS50258
DomainEGF_1

ADAM30 ADAM19 NOTCH1 NOTCH3 NCAN

2.37e-05255265PS00022
DomainEGF-like_CS

ADAM30 ADAM19 NOTCH1 NOTCH3 NCAN

2.65e-05261265IPR013032
DomainEGF_2

ADAM30 ADAM19 NOTCH1 NOTCH3 NCAN

2.85e-05265265PS01186
DomainNotch_dom

NOTCH1 NOTCH3

3.90e-057262IPR000800
DomainNotch

NOTCH1 NOTCH3

3.90e-057262PF00066
DomainNL

NOTCH1 NOTCH3

3.90e-057262SM00004
DomainEGF_extracell

ADAM19 NOTCH1 NOTCH3

7.77e-0560263IPR013111
DomainEGF_2

ADAM19 NOTCH1 NOTCH3

7.77e-0560263PF07974
DomainDisintegrin_CS

ADAM30 ADAM19

2.21e-0416262IPR018358
DomainADAM_CR

ADAM30 ADAM19

2.81e-0418262PF08516
DomainEGF

PCSK5 NOTCH1 NOTCH3 NCAN

2.94e-04235264SM00181
DomainEGF_Ca-bd_CS

NOTCH1 NOTCH3 NCAN

3.24e-0497263IPR018097
DomainEGF_CA

NOTCH1 NOTCH3 NCAN

3.44e-0499263PS01187
Domain-

ADAM30 ADAM19

3.49e-04202624.10.70.10
DomainASX_HYDROXYL

NOTCH1 NOTCH3 NCAN

3.54e-04100263PS00010
DomainDISIN

ADAM30 ADAM19

3.85e-0421262SM00050
DomainDisintegrin

ADAM30 ADAM19

3.85e-0421262PF00200
DomainEGF-type_Asp/Asn_hydroxyl_site

NOTCH1 NOTCH3 NCAN

4.20e-04106263IPR000152
DomainKeratin_2_head

KRT81 KRT86

5.05e-0424262IPR032444
DomainKeratin_2_head

KRT81 KRT86

5.05e-0424262PF16208
DomainKeratin_II

KRT81 KRT86

5.93e-0426262IPR003054
DomainEGF_CA

NOTCH1 NOTCH3 NCAN

6.33e-04122263SM00179
DomainADAM_Cys-rich

ADAM30 ADAM19

6.40e-0427262IPR006586
DomainACR

ADAM30 ADAM19

6.40e-0427262SM00608
DomainEGF-like_Ca-bd_dom

NOTCH1 NOTCH3 NCAN

6.64e-04124263IPR001881
DomainhEGF

NOTCH1 NOTCH3

6.89e-0428262PF12661
DomainEGF

NOTCH1 NOTCH3 NCAN

6.96e-04126263PF00008
DomainGrowth_fac_rcpt_

PCSK5 NOTCH1 NOTCH3

1.29e-03156263IPR009030
DomainPeptidase_M12B_N

ADAM30 ADAM19

1.34e-0339262IPR002870
DomainPep_M12B_propep

ADAM30 ADAM19

1.34e-0339262PF01562
DomainDISINTEGRIN_1

ADAM30 ADAM19

1.41e-0340262PS00427
DomainADAM_MEPRO

ADAM30 ADAM19

1.41e-0340262PS50215
DomainDISINTEGRIN_2

ADAM30 ADAM19

1.41e-0340262PS50214
DomainReprolysin

ADAM30 ADAM19

1.41e-0340262PF01421
DomainPeptidase_M12B

ADAM30 ADAM19

1.41e-0340262IPR001590
DomainCYSTEINE_SWITCH

ADAM30 ADAM19

1.48e-0341262PS00546
DomainDisintegrin_dom

ADAM30 ADAM19

1.48e-0341262IPR001762
DomainPept_M10_metallopeptidase

ADAM30 ADAM19

1.62e-0343262IPR001818
DomainIntermediate_filament_CS

KRT81 KRT86

3.45e-0363262IPR018039
DomainFilament

KRT81 KRT86

4.37e-0371262SM01391
DomainIF

KRT81 KRT86

4.49e-0372262PS00226
Domain-

PCSK5 MYCBP2

4.61e-03732622.60.120.260
DomainFilament

KRT81 KRT86

4.61e-0373262PF00038
DomainIF

KRT81 KRT86

4.99e-0376262IPR001664
DomainMetalloPept_cat_dom

ADAM30 ADAM19

5.64e-0381262IPR024079
Domain-

ADAM30 ADAM19

5.64e-03812623.40.390.10
DomainEGF_CA

NOTCH1 NOTCH3

6.34e-0386262PF07645
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH3

1.91e-055202M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH3

1.91e-055202MM14733
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH3

2.86e-056202M27068
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH1 NOTCH3

4.00e-057202MM14734
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

SEMA5A NOTCH1 NOTCH3 NCAN

4.34e-05143204M27275
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH1 NOTCH3

1.04e-0411202M47865
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

SEMA5A NOTCH1 NOTCH3

1.15e-0468203M27303
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH1 NOTCH3

1.25e-0412202M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH1 NOTCH3

1.25e-0412202M47533
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH3

1.48e-0413202M47423
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH1 NOTCH3

1.48e-0413202M47534
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH3

2.89e-0418202M614
PathwayREACTOME_DISEASES_OF_METABOLISM

SEMA5A NOTCH1 NOTCH3 NCAN

3.74e-04250204M27554
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH1 NOTCH3

4.75e-0423202MM14954
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

NOTCH1 NOTCH3

5.18e-0424202M11190
PathwayREACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

NOTCH1 NOTCH3

5.63e-0425202M27880
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

NOTCH1 WNT7A NOTCH3

5.87e-04118203M39852
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

NOTCH1 NOTCH3

6.57e-0427202M39545
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH1 NOTCH3

7.07e-0428202M6177
PathwayWP_OSX_AND_MIRNAS_IN_TOOTH_DEVELOPMENT

NOTCH1 NOTCH3

1.04e-0334202M39390
PathwayWP_NEOVASCULARIZATION_PROCESSES

NOTCH1 NOTCH3

1.24e-0337202M39506
PathwayWP_BREAST_CANCER_PATHWAY

NOTCH1 WNT7A NOTCH3

1.27e-03154203M39739
PathwayREACTOME_SIGNALING_BY_NOTCH

NOTCH1 NOTCH3

1.37e-0339202MM14604
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

NOTCH1 WNT7A NOTCH3

1.45e-03161203M39770
PathwayWP_NOTCH_SIGNALING_WP268

NOTCH1 NOTCH3

1.83e-0345202M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH3

1.91e-0346202MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH3

1.99e-0347202M7946
PathwayREACTOME_SIGNALING_BY_NOTCH3

NOTCH1 NOTCH3

2.16e-0349202M618
PathwayPID_NOTCH_PATHWAY

NOTCH1 NOTCH3

3.12e-0359202M17
PathwayWP_NOTCH_SIGNALING_WP61

NOTCH1 NOTCH3

3.33e-0361202M39540
PathwayREACTOME_KERATINIZATION

KRT81 KRT86 KRTAP19-2

3.38e-03217203M27640
Pubmed

The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance.

NOTCH1 NOTCH3

5.37e-07226226634853
Pubmed

A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3.

NOTCH1 NOTCH3

5.37e-07226221191019
Pubmed

Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk.

NOTCH1 NOTCH3

5.37e-07226217881497
Pubmed

Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature.

NOTCH1 NOTCH3

5.37e-07226234878922
Pubmed

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

NOTCH1 NOTCH3

5.37e-07226229023469
Pubmed

Nuclear Notch3 expression is associated with tumor recurrence in patients with stage II and III colorectal cancer.

NOTCH1 NOTCH3

5.37e-07226224728738
Pubmed

Distinct roles for Notch1 and Notch3 in human adipose-derived stem/stromal cell adipogenesis.

NOTCH1 NOTCH3

5.37e-07226233021719
Pubmed

Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations.

NOTCH1 NOTCH3

5.37e-07226226563570
Pubmed

A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.

KRT81 KRT86

5.37e-0722629665406
Pubmed

Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation.

NOTCH1 NOTCH3

5.37e-07226214595837
Pubmed

Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis.

NOTCH1 NOTCH3

5.37e-07226221768299
Pubmed

Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway.

NOTCH1 NOTCH3

5.37e-07226225700162
Pubmed

Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis.

NOTCH1 NOTCH3

5.37e-07226218069660
Pubmed

Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.

NOTCH1 NOTCH3

5.37e-07226216507912
Pubmed

A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.

KRT81 KRT86

5.37e-0722629402962
Pubmed

Overlapping but distinct roles for NOTCH receptors in human cardiovascular disease.

NOTCH1 NOTCH3

1.61e-06326229767458
Pubmed

The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation.

NOTCH1 NOTCH3

1.61e-0632627698746
Pubmed

Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro.

NOTCH1 NOTCH3

1.61e-06326215987768
Pubmed

Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate.

NOTCH1 NOTCH3

1.61e-0632627615640
Pubmed

Notch receptor expression in human brain arteriovenous malformations.

NOTCH1 NOTCH3

1.61e-06326225846406
Pubmed

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.

NOTCH1 NOTCH3

1.61e-0632627918097
Pubmed

Complementary and combinatorial patterns of Notch gene family expression during early mouse development.

NOTCH1 NOTCH3

1.61e-0632628645602
Pubmed

Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression.

NOTCH1 NOTCH3

1.61e-06326231346528
Pubmed

PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study.

NOTCH1 NOTCH3

1.61e-06326234846251
Pubmed

Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study.

NOTCH1 NOTCH3

1.61e-06326221471519
Pubmed

Hepatitis B virus X protein and hypoxia‑inducible factor-1α stimulate Notch gene expression in liver cancer cells.

NOTCH1 NOTCH3

1.61e-06326227840976
Pubmed

Smooth muscle Notch1 mediates neointimal formation after vascular injury.

NOTCH1 NOTCH3

1.61e-06326219433762
Pubmed

Sequence data and chromosomal localization of human type I and type II hair keratin genes.

KRT81 KRT86

1.61e-0632627556444
Pubmed

Novel KRT83 and KRT86 mutations associated with monilethrix.

KRT81 KRT86

1.61e-06326225557232
Pubmed

Structure and site of expression of a murine type II hair keratin.

KRT81 KRT86

1.61e-0632621372089
Pubmed

Effect of notch1,2,3 genes silicing on NF-κB signaling pathway of macrophages in patients with atherosclerosis.

NOTCH1 NOTCH3

1.61e-06326227697639
Pubmed

NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.

NOTCH1 NOTCH3

1.61e-06326220801121
Pubmed

Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells.

NOTCH1 NOTCH3

1.61e-06326218483410
Pubmed

Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.

KRT81 KRT86

1.61e-0632621712823
Pubmed

Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells.

NOTCH1 NOTCH3

1.61e-06326233664344
Pubmed

KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.

NOTCH1 NOTCH3

1.61e-06326234854382
Pubmed

Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.

NOTCH1 NOTCH3

3.22e-06426211978185
Pubmed

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

NOTCH1 NOTCH3

3.22e-06426211459941
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH1 NOTCH3

3.22e-06426228061457
Pubmed

Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.

NOTCH1 NOTCH3

3.22e-06426221673954
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH1 NOTCH3

3.22e-06426224145721
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH1 NOTCH3

3.22e-06426220069356
Pubmed

Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle.

KRT81 KRT86

3.22e-0642629457912
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH1 NOTCH3

3.22e-06426219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH1 NOTCH3

3.22e-06426228669409
Pubmed

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods.

NOTCH1 NOTCH3

3.22e-06426210551863
Pubmed

p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro.

NOTCH1 NOTCH3

3.22e-06426212391150
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH1 NOTCH3

3.22e-06426211466531
Pubmed

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

NOTCH1 NOTCH3

3.22e-06426220829372
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH1 NOTCH3

3.22e-06426224151014
Pubmed

Activation of Notch signaling in human tongue carcinoma.

NOTCH1 NOTCH3

3.22e-06426220819128
Pubmed

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

NOTCH1 NOTCH3

3.22e-06426218184405
Pubmed

CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma.

NOTCH1 NOTCH3

3.22e-06426222705236
Pubmed

Keratins of the human hair follicle.

KRT81 KRT86

3.22e-06426215797458
Pubmed

Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.

NOTCH1 NOTCH3

3.22e-06426220040020
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH1 NOTCH3

3.22e-06426211401408
Pubmed

Notch signaling in the mammalian central nervous system: insights from mouse mutants.

NOTCH1 NOTCH3

3.22e-06426215917835
Pubmed

Novel MIR143-NOTCH fusions in benign and malignant glomus tumors.

NOTCH1 NOTCH3

3.22e-06426223999936
Pubmed

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

NOTCH1 NOTCH3

3.22e-06426229170450
Pubmed

Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

NOTCH1 NOTCH3

3.22e-06426210194420
Pubmed

NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells.

NOTCH1 NOTCH3

3.22e-06426218156632
Pubmed

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.

NOTCH1 NOTCH3

3.22e-06426223444212
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH1 NOTCH3

3.22e-0642628898100
Pubmed

Assignment of lysosomal alpha-D-mannosidase to mouse chromosome 8.

MAN2B1 NCAN

3.22e-0642628829553
Pubmed

Deregulated expression of Notch receptors in human hepatocellular carcinoma.

NOTCH1 NOTCH3

3.22e-06426217920003
Pubmed

Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos.

NOTCH1 NOTCH3

3.22e-06426211044625
Pubmed

Notch signaling in bulge stem cells is not required for selection of hair follicle fate.

NOTCH1 NOTCH3

5.37e-06526219211676
Pubmed

Notch expression in developing olfactory neuroepithelium.

NOTCH1 NOTCH3

5.37e-06526215076712
Pubmed

Notch3 drives development and progression of cholangiocarcinoma.

NOTCH1 NOTCH3

5.37e-06526227791012
Pubmed

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

NOTCH1 NOTCH3

5.37e-06526227040987
Pubmed

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.

NOTCH1 NOTCH3

5.37e-06526211006133
Pubmed

Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.

NOTCH1 NOTCH3

5.37e-06526221124806
Pubmed

Chimeric analysis of Notch2 function: a role for Notch2 in the development of the roof plate of the mouse brain.

NOTCH1 NOTCH3

5.37e-06526212242712
Pubmed

Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

NOTCH1 NOTCH3

5.37e-06526215882997
Pubmed

Deficiency of Notch signaling in pericytes results in arteriovenous malformations.

NOTCH1 NOTCH3

5.37e-06526233148887
Pubmed

Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells.

NOTCH1 NOTCH3

5.37e-06526215879553
Pubmed

Functional diversity of notch family genes in fetal lung development.

NOTCH1 NOTCH3

5.37e-06526215064243
Pubmed

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

NOTCH1 NOTCH3

5.37e-06526221562564
Pubmed

Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

NOTCH1 NOTCH3

5.37e-06526223675950
Pubmed

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

NOTCH1 NOTCH3

5.37e-06526211101851
Pubmed

Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1.

NOTCH1 NOTCH3

5.37e-06526220554499
Pubmed

RBP-L, a transcription factor related to RBP-Jkappa.

NOTCH1 NOTCH3

8.05e-0662629111338
Pubmed

Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression.

NOTCH1 NOTCH3

8.05e-06626211731257
Pubmed

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

NOTCH1 NOTCH3

8.05e-06626220870902
Pubmed

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.

NOTCH1 NOTCH3

8.05e-06626226062937
Pubmed

A study on Notch signaling in human breast cancer.

NOTCH1 NOTCH3

8.05e-06626217822320
Pubmed

The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity.

NOTCH1 NOTCH3

8.05e-06626211404076
Pubmed

Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura.

NOTCH1 NOTCH3

8.05e-06626219603167
Pubmed

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

NOTCH1 NOTCH3

8.05e-0662627835890
Pubmed

ALDH maintains the stemness of lung adenoma stem cells by suppressing the Notch/CDK2/CCNE pathway.

NOTCH1 NOTCH3

8.05e-06626224671051
Pubmed

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

NOTCH1 NOTCH3

8.05e-06626218299578
Pubmed

Characterization of Notch receptor expression in the developing mammalian heart and liver.

NOTCH1 NOTCH3

8.05e-06626212244553
Pubmed

Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary.

NOTCH1 NOTCH3

8.05e-06626222526456
Pubmed

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes.

NOTCH1 NOTCH3

8.05e-06626231249304
Pubmed

Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4.

NOTCH1 NOTCH3

8.05e-0662629108364
Pubmed

Loss of notch activity in the developing central nervous system leads to increased cell death.

NOTCH1 NOTCH3

8.05e-06626216508303
Pubmed

Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation.

NOTCH1 NOTCH3

8.05e-0662629882480
Pubmed

Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.

NOTCH1 NOTCH3

8.05e-06626215019995
Pubmed

Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.

NOTCH1 NOTCH3

8.05e-06626219503073
Pubmed

Notch controls the magnitude of T helper cell responses by promoting cellular longevity.

NOTCH1 NOTCH3

8.05e-06626222615412
InteractionIGFL3 interactions

PCSK5 MYCBP2 NOTCH1 NOTCH3

2.11e-0675254int:IGFL3
Cytoband12q13

KRT81 KRT86

7.48e-047126212q13
CytobandEnsembl 112 genes in cytogenetic band chr19p13

MAN2B1 ZNF491 NOTCH3 NCAN

9.94e-04797264chr19p13
GeneFamilyKeratins, type II

KRT81 KRT86

4.01e-0427202609
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM30 ADAM19

4.01e-042720247
GeneFamilyAnkyrin repeat domain containing

NOTCH1 NOTCH3

2.89e-02242202403
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

TC2N MAN2B1 LY6G6D KRT81 NOTCH1 KRT86

1.88e-05610256M3854
CoexpressionMARTINEZ_TP53_TARGETS_DN

TC2N MAN2B1 LY6G6D KRT81 NOTCH1 KRT86

1.97e-05615256M8673
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

TC2N MAN2B1 LY6G6D KRT81 NOTCH1 KRT86

2.69e-05650256MM1042
CoexpressionMARTINEZ_TP53_TARGETS_DN

TC2N MAN2B1 LY6G6D KRT81 NOTCH1 KRT86

2.91e-05659256MM1040
CoexpressionGSE22935_UNSTIM_VS_12H_MBOVIS_BCG_STIM_MYD88_KO_MACROPHAGE_UP

PCSK5 KRT81 NOTCH3 NCAN

3.67e-05200254M7758
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

NOTCH1 NOTCH3

1.04e-0416252M2207
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

NOTCH1 NOTCH3

1.04e-0416252MM1296
CoexpressionMOREIRA_RESPONSE_TO_TSA_DN

NOTCH1 WNT7A

1.32e-0418252M3506
CoexpressionMARTINEZ_RB1_TARGETS_DN

TC2N LY6G6D KRT81 NOTCH1 KRT86

1.76e-04569255M12701
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL2A

TC2N NOTCH1 NADK2 WNT7A NCAN

2.25e-04600255M39055
CoexpressionMARTINEZ_RB1_TARGETS_DN

TC2N LY6G6D KRT81 NOTCH1 KRT86

2.81e-04630255MM1038
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN

NOTCH1 WNT7A NOTCH3

2.83e-04135253M5825
CoexpressionNABA_MATRISOME

PCSK5 ADAM30 SEMA5A ADAM19 WNT7A NCAN

3.01e-041008256MM17056
ToppCell10x3'2.3-week_14-16-Lymphocytic_NK-T_NK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 WNT7A KRT86

4.28e-0619026467fa7472ec534179087963177351552cc3c335eb
ToppCell10x3'2.3-week_14-16-Lymphocytic_NK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 WNT7A KRT86

4.28e-06190264094efcde2b037ae509298abb8b2b1d52f9c86a45
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nxph3|Hippocampus / BrainAtlas - Mouse McCarroll V32

PCSK5 KRT81 KRT86

8.01e-0667263b80bdd122a0284611161c40ec7a9c893dc8de4de
ToppCellfacs-Trachea-nan-18m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM184A NKAIN2 KRT81

9.10e-051512635aa98ca9abe37edbc750fd970852a1cc903a5881
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TC2N ARSF MCOLN2

1.02e-04157263f2bc60ec0305b056d79f1b7fd6b5e3730d606916
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5A NOTCH1 NOTCH3

1.02e-04157263c779a53b2c67d566f5d417e753cd17196a6bfd1c
ToppCell367C-Lymphocytic-ILC|367C / Donor, Lineage, Cell class and subclass (all cells)

TC2N KRT81 KRT86

1.08e-04160263f70ec054b6d51c1565e4a257cbe3c9537c0eb09f
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

TC2N KRT81 KRT86

1.10e-04161263a1f10e04836848b1deaf295fae033f54d1572fcd
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TC2N ARSF MCOLN2

1.12e-041622634b9f80f701dcbb2508f497095cb8a7a2ca51cb5e
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCDHAC2 SEMA5A NOTCH3

1.16e-041642638d1d0424943d3e98c8b6399dbf702e0035d0db7b
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PCDHAC2 ARSF MYCBP2

1.16e-041642634d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCellICU-SEP-Lymphocyte-T_NK-MAIT|ICU-SEP / Disease, Lineage and Cell Type

TC2N TMEM184A KRT86

1.16e-04164263db863a44fc0dad5518c47fdbf64ea21d6f36f089
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D3|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ADAM19 KRT81 KRT86

1.25e-041682636501495b7ad252af330b18011696c43031541018
ToppCell367C-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CHM KRT81 KRT86

1.25e-0416826380233a13135fd159f5764336a1fe67fba237776b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 SEMA5A TC2N

1.25e-041682637abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCelldroplet-Thymus-nan-18m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TC2N TMEM184A KRT86

1.27e-041692634ac21e8199de4b6917eacadc56fffc6d886ee643
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_PENK|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 SEMA5A ARSF

1.27e-04169263eb3b8e473192c4b8688f2f8da400116dd6fe193d
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA5A KRT81 KRT86

1.29e-04170263ce79f5d0d475fcb6c5a61c94938c65210b3c59d9
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo|Lung / Manually curated celltypes from each tissue

TC2N KRT81 MCOLN2

1.32e-04171263dfd4a15ab68ef5a9a1954b1b1540ae04017885a6
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.32e-041712634fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA5A TC2N LY6G6D

1.41e-04175263c1a8a55af825d5913095f919fa860828df9c273e
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA5A TC2N LY6G6D

1.41e-0417526378b453e220218c84557f244ef7a760e4a1952761
ToppCellCOPD-Lymphoid-ILC_A|World / Disease state, Lineage and Cell class

TC2N KRT81 KRT86

1.41e-04175263e773e330de36f8a0aa9398a176ed7edb5599c582
ToppCellCOPD-Lymphoid-ILC_A|COPD / Disease state, Lineage and Cell class

TC2N KRT81 KRT86

1.43e-04176263484452cb38fe4604f0910a068361ed461b5b0c21
ToppCellmetastatic_Brain-Myeloid_cells-CD141+_DCs|metastatic_Brain / Location, Cell class and cell subclass

ADAM19 TAP2 MCOLN2

1.43e-04176263b9ba7026dee2272c0b483dc0cfa39f74b75f1634
ToppCellDendritic_Cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ADAM19 TAP2 MCOLN2

1.46e-04177263d2cd081bdda0eba9f6f6473c4d3939e4bee3440e
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.46e-04177263507f06d31ab773099c9431b6f433899dc97b5566
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 SEMA5A TC2N

1.46e-04177263bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.46e-041772638887ff6341eb070bdaa890cc2cd7745f0cf1b0af
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.51e-04179263c9f45cfea0ceb0cdc31bcfd123aeab69aeb35c35
ToppCell10x5'v1-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 KRT86

1.51e-04179263bc95c3e7edc5fc6fc913b09f087d221df64c6f48
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

ADAM19 TAP2 MCOLN2

1.53e-04180263a0b35067b6f2dbd8145da8bab760e9f650f045b0
ToppCell10x5'v1-week_14-16-Lymphocytic_NK-T_NK-ILC_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 KRT86

1.53e-04180263a999a6d219a8e58a8b63802ddf8c95ffaab9cfa0
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 ADAM19 ZNF491

1.58e-0418226352274af3136d4fd4a495f5882618444661421f0f
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 ADAM19 ZNF491

1.58e-04182263dfde2d9950f445c6c936ac828f7210de87bb45ec
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAM19 TC2N WNT7A

1.58e-041822639ba85f621a846531a2a7861e9df695d288c9e149
ToppCellIPF-Lymphoid-ILC_A|World / Disease state, Lineage and Cell class

TC2N KRT81 KRT86

1.58e-04182263f91bb45baaec76cb3bb26eedbcf0709b2492e93f
ToppCellDendritic_Cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

ADAM19 LY6G6D MCOLN2

1.61e-04183263499da89b4abe7b746e703cd1e5c56f9b1d97ac3c
ToppCellIPF-Lymphoid-ILC_A|IPF / Disease state, Lineage and Cell class

TC2N KRT81 KRT86

1.61e-0418326349bfeaae13eb236f61a5486ee75c39789936bb8a
ToppCellT_cells-Resident_memory_CD8+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

TC2N KRT81 KRT86

1.63e-04184263e04cabff33a8e36967622ec3e5b37b89afa7e148
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

ADAM19 MYCBP2 MCOLN2

1.66e-04185263a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-NK_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TC2N KRT81 KRT86

1.69e-04186263885aed2472cead81d60c9f3a28c0ff10eb449592
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.69e-041862630096a61b1841784c913752b4f3639200446cc02c
ToppCell10x3'2.3-week_14-16-Lymphocytic_NK-T_NK-CD56_bright_NK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 WNT7A

1.69e-04186263e0eeef2b9e06324354c5a11a4c6d4c98546f32af
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.69e-041862639e159ad7289dcae2ec7ce655df746f46801b81d3
ToppCellwk_08-11-Hematologic_Lymphocytic-NK-CD56bright_NK|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TC2N KRT81 KRT86

1.69e-041862637b67e588b3c95074367b2cf20d2fc72d1385ee28
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TC2N KRT81 KRT86

1.69e-04186263428b4cbee3d3ab666cab2fc2d9c815318359e458
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.69e-041862636345777847960c71a2ba3ce5a49c72c34ebd0e73
ToppCellsaliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TC2N TAP2 KRT86

1.71e-0418726343ef900b76f3c38bd8ce9858201124130c743d56
ToppCell368C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CHM KRT81 KRT86

1.71e-04187263c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PCSK5 SEMA5A ADAM19

1.71e-04187263387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCellsaliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TC2N TAP2 KRT86

1.71e-041872636e5c38425b6b1d4774f8dcea7e146f1eab785c3e
ToppCell368C-Lymphocytic-NK_cells-NK_cell_D3|368C / Donor, Lineage, Cell class and subclass (all cells)

CHM KRT81 KRT86

1.74e-04188263ecc2364d946f97ae0212fd6739960c9fc75e4919
ToppCelltumor_Lung-Myeloid_cells-CD141+_DCs|Myeloid_cells / Location, Cell class and cell subclass

ADAM19 TAP2 MCOLN2

1.74e-041882639874ba56bf6a0d509cccc89563dbf1395e17e84e
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA5A ADAM19 NOTCH3

1.77e-04189263f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 KRT86

1.77e-04189263723c57f278919e8251d56b3d19411f9088319450
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 KRT86

1.77e-04189263960374f5fb278659500a7c948c3068a95dd62eb0
ToppCellwk_20-22-Hematologic_Lymphocytic-NK-CD56bright_NK|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TC2N KRT81 KRT86

1.79e-04190263c8031df82c3662ce4140c850277987f7210e9bcd
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 TAP2 MCOLN2

1.82e-04191263f814dc20034bafa1c0e8dfe98e58370cf3f73bee
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 TAP2 MCOLN2

1.82e-041912631155c28407ff97d950d70d53256a9fb6307a2bac
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 TAP2 MCOLN2

1.82e-041912638947010e47218095c5032f24c41e245e7977a33d
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

ADAM19 MYCBP2 MCOLN2

1.82e-041912639454f642c3621370fa23640b631301346b300950
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAM19 TC2N WNT7A

1.82e-04191263b53b490a8796e819edd3eb4a5a42b4499077b2d3
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAM19 TC2N WNT7A

1.82e-041912639c747f8cc1cdce45e839b661d782e1e8cfb79578
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-NK|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT81 KRT86 MCOLN2

1.85e-04192263930319cbd82b9e54864147ffcdc8bd0ea7b937be
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT81 KRT86 MCOLN2

1.85e-04192263c7bcebcb88a25b2c97d798120efa9d5958e7f798
ToppCellHealthy_donor-CD4+_Tcm|World / disease group, cell group and cell class (v2)

SEMA5A TC2N WNT7A

1.85e-041922631603903454ba6bf65c8e13ede620e0b1e8fbd7ec
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADAM19 MAN2B1 MCOLN2

1.88e-041932635a4accf3af236ff285942163c45277a80263f421
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SEMA5A ADAM19 NOTCH3

1.88e-04193263000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCellHealthy/Control-CD4+_Tcm|Healthy/Control / Disease group and Cell class

SEMA5A TC2N WNT7A

1.91e-0419426308b25c41566d071e079e492cb2c33015b80da72d
ToppCell10x5'v1-week_12-13-Lymphocytic_NK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 KRT86

1.91e-041942635afe7f48d3383f3dac18765f97999c8b6936dc1b
ToppCellHealthy/Control-CD4+_Tcm|World / Disease group and Cell class

SEMA5A TC2N WNT7A

1.91e-04194263cbdd1786305108cbeddea07a21120067d78c59a0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SEMA5A ADAM19 NOTCH3

1.91e-0419426367f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell10x5'v1-week_12-13-Lymphocytic_NK-T_NK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TC2N KRT81 KRT86

1.91e-04194263ec7e0ca6c9a2f63938e06ee771da09eff14fc3b5
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADAM19 MAN2B1 MCOLN2

1.94e-04195263de60fa0c69c835f0b1d6d2dba1a1acd73246b001
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TC2N KRT81 KRT86

1.94e-04195263d81ac3a8f2b7b767bdd03641ab6329917273cd75
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.97e-04196263787088ce800d7148bad7265a971797da597b029a
ToppCellControl-Lymphocyte-T_NK-NK_CD56bright|Control / Disease, Lineage and Cell Type

TC2N KRT81 KRT86

1.97e-04196263c0ebef067aa333c7a18c697031b0417b3335b75c
ToppCell5'-Airway_Nasal-Immune_Myeloid|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

1.97e-041962639c942bf9fc78caa173d2c7de5fe4c17f076c623b
ToppCell367C-Lymphocytic-NK_cells|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 KRT81 KRT86

1.97e-04196263c6fac4ead13834483e780188de7d417e5cf37611
ToppCellCOVID-19-kidney-T-cells-1|kidney / Disease (COVID-19 only), tissue and cell type

ADAM19 TC2N MCOLN2

2.00e-041972639bb7faf4ef63cca4d06c60e6c05a9616fdb6b98e
ToppCellBiopsy_Control_(H.)-Immune-B_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ADAM30 ADAM19 MCOLN2

2.00e-04197263c78e0cf394b9a4e10ebba61f6392d9b5a23db9d8
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK-ILC|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

KRT81 KRT86 MCOLN2

2.00e-041972639791923feefbd78810242113ad2a08ce4c2bb4f2
ToppCellVE-NK|VE / Condition, Cell_class and T cell subcluster

KRT81 NOTCH1 KRT86

2.00e-04197263cae6ff8763501e7a5897b50188ac2640d65a47c0
ToppCellmLN-T_cell-Th1|T_cell / Region, Cell class and subclass

TMEM184A KRT86 NOTCH3

2.00e-041972635e39a49dddef04469ff2b615d755ddf6a926e58e
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial|6_mon / Sample Type, Dataset, Time_group, and Cell type.

SEMA5A NOTCH1 NCAN

2.00e-04197263965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia|6_mon / Sample Type, Dataset, Time_group, and Cell type.

SEMA5A NOTCH1 NCAN

2.00e-041972633f088eb29197bc575400d6dafd8083e69e4a149f
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

2.00e-04197263515a2d0ee2bd3fc0a5a0c315e2b0c752e6af7406
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

2.00e-041972634fccdc69ab4b966de6465f06677435e6f6e6abcd
ToppCellVE-NK-|VE / Condition, Cell_class and T cell subcluster

KRT81 NOTCH1 KRT86

2.00e-04197263ee89b8521fb4faaed9e4d39f7171e45eccf38b00
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM19 MAN2B1 MCOLN2

2.00e-04197263bfa04e5f4156a01df4217b1f59676edb0a7563e1
ToppCellBronchial-10x5prime-Immune_Lymphocytic-T-T_CD8-gdT|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KRT81 KRT86 MCOLN2

2.03e-041982639dc91a1101eef649a301f0147ecd5c028a9c2b12
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA5A NOTCH1 NOTCH3

2.03e-0419826319d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAM19 TC2N WNT7A

2.03e-04198263d24e3c9bafd6df52eefcca5e8dcd493f72c2583a
ToppCell390C-Lymphocytic-NK_cells|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 KRT81 KRT86

2.03e-04198263623e5ada1a54cd42c32a1519b84dbe782384ee0c
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Teffector/EM_CD4|Lung / Manually curated celltypes from each tissue

ADAM19 TC2N WNT7A

2.06e-0419926354b6a43e23826d507b8f1db578e589711d49bbfd
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC1|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADAM19 TAP2 MCOLN2

2.06e-04199263c6da5c517dbcfa621fa6dda9e0c1985ba2f3bbdb
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SEMA5A MYCBP2 MCOLN2

2.06e-04199263a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC1-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADAM19 TAP2 MCOLN2

2.06e-04199263b9613e88c4b752529d6ae20857744418207b0830
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-MAIT|ICU-SEP / Disease, condition lineage and cell class

TC2N TMEM184A KRT86

2.06e-041992632f10622319c6146dfed8cfe3844180c1e1d56e94
Diseasehair disease (is_implicated_in)

KRT81 KRT86

5.81e-072232DOID:421 (is_implicated_in)
DiseaseMONILETHRIX

KRT81 KRT86

1.74e-063232158000
Diseasemonilethrix (is_implicated_in)

KRT81 KRT86

1.74e-063232DOID:0050472 (is_implicated_in)
DiseaseBeaded hair

KRT81 KRT86

1.74e-063232cv:C0546966
DiseaseMonilethrix

KRT81 KRT86

3.48e-064232C0546966
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH1 NOTCH3

1.22e-057232DOID:3620 (implicated_via_orthology)
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH1 NOTCH3

1.22e-057232DOID:299 (implicated_via_orthology)
DiseaseCarcinoma, Pancreatic Ductal

NOTCH1 NOTCH3

1.59e-0424232C0887833
Diseasebrain cancer (implicated_via_orthology)

NOTCH1 NOTCH3

1.87e-0426232DOID:1319 (implicated_via_orthology)
Diseasecolorectal cancer (implicated_via_orthology)

NOTCH1 NOTCH3

2.49e-0430232DOID:9256 (implicated_via_orthology)
Diseaseintestinal cancer (implicated_via_orthology)

NOTCH1 NOTCH3

2.84e-0432232DOID:10155 (implicated_via_orthology)
Diseaseinflammatory bowel disease

PCSK5 ADAM30 TC2N NOTCH1

3.72e-04449234EFO_0003767
Diseaseclinical treatment

MYCBP2 TAP2

4.68e-0441232EFO_0007056
DiseaseSkin Neoplasms

NOTCH1 NOTCH3

9.68e-0459232C0037286
DiseaseMalignant neoplasm of skin

NOTCH1 NOTCH3

9.68e-0459232C0007114
DiseaseGlioblastoma

NOTCH1 NOTCH3

1.73e-0379232C0017636
DiseaseParkinson disease

SEMA5A NKAIN2 MYCBP2

1.92e-03321233MONDO_0005180
DiseaseGiant Cell Glioblastoma

NOTCH1 NOTCH3

1.95e-0384232C0334588

Protein segments in the cluster

PeptideGeneStartEntry
ASGGCYVTSLCRCFG

ARSF

481

P54793
CEGGQAYCYNGMCLT

ADAM19

506

Q9H013
CFCRMCAVFGGIYCL

CHM

386

P24386
MCYGYGCGCGSFCRL

KRTAP19-2

1

Q3LHN2
GTCKDMTSGYVCTCR

NOTCH1

766

P46531
MTSGYVCTCREGFSG

NOTCH1

771

P46531
MTCYRGFLLGSCCRV

NADK2

1

Q4G0N4
MTCGSYCGGRAFSCI

KRT86

1

O43790
CFGSHGDQCMSCKYG

PCSK5

696

Q92824
MGYCSGRCTLIFICG

NKAIN2

1

Q5VXU1
GQFTCICMAGFTGTY

NOTCH3

451

Q9UM47
AYGTACCGGFCGVRE

PCDHAC2

736

Q9Y5I4
CIMGSGRTGFSNCSY

ADAM30

361

Q9UKF2
MGAYARASGVCARGC

MAN2B1

1

O00754
AMGSAYGSCTCLGAQ

C3orf56

36

Q8N813
CACAGMIYLGYTFCG

MCOLN2

421

Q8IZK6
RMRCYNCGGSPSSSC

LY6G6D

21

O95868
MATEFIKSCCGGCFY

TC2N

1

Q8N9U0
SCLYGTCCLRGMTYS

TMEM184A

161

Q6ZMB5
GTCNANGTMYGCSCD

NCAN

1021

O14594
SAGCRGGCFTYTMSR

TAP2

206

Q03519
CMVCTVCGDCTGYGA

MYCBP2

766

O75592
TKCSATCGGGHYMRT

SEMA5A

851

Q13591
ASGCDLMCCGRGYNT

WNT7A

301

O00755
SCESGTCGEIFMGYS

ZNF491

36

Q8N8L2
LVCLCSGLGASFCYM

TMEM41B

151

Q5BJD5
IVSMACCASGSTRGY

AGL

646

P35573
MTCGSGFGGRAFSCI

KRT81

1

Q14533