Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	C2	MYOF RIMS1 CCDC33	1.31e-03	131	31	3	PF00168
Domain	Znf_FYVE-rel	RIMS1 HGS	1.45e-03	34	31	2	IPR017455
Domain	C2	MYOF RIMS1 CCDC33	1.49e-03	137	31	3	SM00239
Domain	C2	MYOF RIMS1 CCDC33	1.65e-03	142	31	3	PS50004
Domain	Znf_FYVE	RIMS1 HGS	1.81e-03	38	31	2	IPR000306
Domain	-	MYOF RIMS1 CCDC33	1.86e-03	148	31	3	2.60.40.150
Domain	ZF_FYVE	RIMS1 HGS	2.00e-03	40	31	2	PS50178
Domain	C2_dom	MYOF RIMS1 CCDC33	2.49e-03	164	31	3	IPR000008
Domain	Ank_2	TANC2 ANKRD50 ANKRD53	5.33e-03	215	31	3	PF12796
Domain	Ank	TANC2 ANKRD50 ANKRD53	6.27e-03	228	31	3	PF00023
Domain	-	TANC2 ANKRD50 ANKRD53	7.90e-03	248	31	3	1.25.40.20
Domain	ANK	TANC2 ANKRD50 ANKRD53	8.17e-03	251	31	3	SM00248
Domain	ANK_REPEAT	TANC2 ANKRD50 ANKRD53	8.35e-03	253	31	3	PS50088
Domain	Ankyrin_rpt-contain_dom	TANC2 ANKRD50 ANKRD53	8.44e-03	254	31	3	IPR020683
Domain	ANK_REP_REGION	TANC2 ANKRD50 ANKRD53	8.44e-03	254	31	3	PS50297
Domain	Ankyrin_rpt	TANC2 ANKRD50 ANKRD53	9.18e-03	262	31	3	IPR002110
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	MED15 KLF4 MED7 MED13	5.28e-06	84	20	4	M1008
Pathway	REACTOME_ADIPOGENESIS	MED15 KLF4 MED7 MED13	1.54e-05	110	20	4	M48259
Pubmed	A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.	MED15 MED7 MED13	2.21e-07	13	33	3	14657022
Pubmed	Structure, function, and activator-induced conformations of the CRSP coactivator.	MED15 MED7 MED13	2.81e-07	14	33	3	11834832
Pubmed	Composite co-activator ARC mediates chromatin-directed transcriptional activation.	MED15 MED7 MED13	1.36e-06	23	33	3	10235267
Pubmed	MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.	MED15 MED7 MED13	4.56e-06	34	33	3	15989967
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MED15 MED7 MED13	6.95e-06	39	33	3	38690566
Pubmed	A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.	MED15 MED7 MED13	1.23e-05	47	33	3	15175163
Pubmed	HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.	MED15 MED13	3.91e-05	10	33	2	23746844
Pubmed	Human mediator subunit MED26 functions as a docking site for transcription elongation factors.	MED15 MED7 MED13	4.63e-05	73	33	3	21729782
Pubmed	ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1.	MLKL TICAM2	4.78e-05	11	33	2	38548850
Pubmed	A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.	MED7 MED13	5.73e-05	12	33	2	23563140
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	MED15 CSTF3 KANSL2 MED7 MED13	6.44e-05	453	33	5	29656893
Pubmed	CDK8 is a positive regulator of transcriptional elongation within the serum response network.	MED15 MED13	6.77e-05	13	33	2	20098423
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DIP2B MYOF KANSL2 RIMS1 SF3B2 MED13	7.90e-05	774	33	6	15302935
Pubmed	Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.	MED15 MED13	9.10e-05	15	33	2	18418385
Pubmed	CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation.	SHC1 PSG6	9.10e-05	15	33	2	15467833
Pubmed	Shc and CEACAM1 interact to regulate the mitogenic action of insulin.	SHC1 PSG6	1.04e-04	16	33	2	11694516
Pubmed	The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.	MED7 MED13	1.04e-04	16	33	2	10882111
Pubmed	Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.	MED7 MED13	1.18e-04	17	33	2	10235266
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	MED15 MYOF MED7 SF3B2	1.46e-04	283	33	4	18854154
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	MED15 MED13	1.48e-04	19	33	2	16799563
Pubmed	Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.	MED7 MED13	1.64e-04	20	33	2	15340084
Pubmed	The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.	MED7 MED13	1.99e-04	22	33	2	11867769
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	SHC1 TANC2 CSTF3 MLKL SF3B2	2.08e-04	582	33	5	20467437
Pubmed	Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.	MED15 MED7	2.80e-04	26	33	2	24882805
Pubmed	Novel critical role of a human Mediator complex for basal RNA polymerase II transcription.	MED15 MED7	2.80e-04	26	33	2	11559591
Pubmed	Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.	MED15 MED13	2.80e-04	26	33	2	34506481
Pubmed	Mediator and cohesin connect gene expression and chromatin architecture.	MED15 MED7	3.25e-04	28	33	2	20720539
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DIP2B NOL9 ANKRD50 SF3B2 MYO19	3.46e-04	650	33	5	38777146
Pubmed	A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.	MED7 MED13	3.49e-04	29	33	2	14638676
Pubmed	The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.	MED15 MED13	3.99e-04	31	33	2	23322298
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	MED15 MED7 MED13	5.34e-04	167	33	3	20362541
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SHC1 TANC2 MYOF KLF4 ZNF341 MED13	5.39e-04	1105	33	6	35748872
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	ANKRD50 MED7 ZNF341 HGS CCDC33	6.31e-04	742	33	5	26871637
Pubmed	Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.	MED7 HGS	6.33e-04	39	33	2	22458338
Pubmed	Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration.	SHC1 MED15	7.69e-04	43	33	2	36878279
Pubmed	Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	RIMS1 NSG1	8.80e-04	46	33	2	37207277
Interaction	MED30 interactions	MED15 MED7 MED13 HGS	9.24e-06	84	32	4	int:MED30
Interaction	MED22 interactions	MED15 MED7 MED13 HGS	9.68e-06	85	32	4	int:MED22
Interaction	MED7 interactions	MED15 MED7 MED13 HGS	1.33e-05	92	32	4	int:MED7
Interaction	MED25 interactions	MED15 MED7 MED13 HGS	1.38e-05	93	32	4	int:MED25
Interaction	MED12L interactions	MED15 MED7 MED13	5.62e-05	47	32	3	int:MED12L
Interaction	MED21 interactions	MED15 MED7 MED13 HGS	1.13e-04	159	32	4	int:MED21
Cytoband	5q33.3	CCNJL MED7	3.11e-04	36	33	2	5q33.3
GeneFamily	Cyclins\|Mediator complex	MED15 MED7 MED13	1.09e-05	33	24	3	1061
GeneFamily	Ankyrin repeat domain containing	TANC2 ANKRD50 ANKRD53	3.89e-03	242	24	3	403
GeneFamily	Adenosine receptors\|V-set domain containing	HEPACAM2 PSG6	1.96e-02	163	24	2	590
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	DIP2B ANKRD50 CPLANE1 MED13	1.07e-05	193	32	4	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCNJL HEPACAM2 KLF4 CFAP65	1.14e-05	196	32	4	847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCNJL HEPACAM2 KLF4 CFAP65	1.16e-05	197	32	4	d624f3a105b19f19a0dd253ce8de3ed13adc1f01
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	DIP2B MED13	1.53e-04	17	32	2	DOID:0060307 (is_implicated_in)
Disease	Disorder of eye	RIMS1 CPLANE1 USH2A	1.56e-03	212	32	3	C0015397
Disease	Retinitis pigmentosa	USH2A SLC7A14	2.93e-03	74	32	2	cv:C0035334
Disease	Neurodevelopmental Disorders	TANC2 RIMS1	4.58e-03	93	32	2	C1535926
Disease	DNA methylation	RIMS1 ANKRD50 USH2A NSG1	5.31e-03	656	32	4	GO_0006306
Disease	Retinitis Pigmentosa	USH2A SLC7A14	5.70e-03	104	32	2	C0035334
Disease	Ciliopathies	CPLANE1 USH2A	6.35e-03	110	32	2	C4277690
Disease	macrophage inflammatory protein 1b measurement	NOL9 MYO19	9.55e-03	136	32	2	EFO_0008219
Disease	facial height measurement	MED13 CCDC33	1.04e-02	142	32	2	EFO_0007856

Protein segments in the cluster

Peptide	Gene	Start	Entry
IYPRPDQPRMNPKAQ	CCDC33	141	Q8N5R6
PYQPLQPLDMCPVPV	CCNJL	381	Q8IV13
PLLGMKPPQQSLYLL	ANKRD50	176	Q9ULJ7
PQPLLPAYILLMLPS	CECR9	76	P0C854
LQCIPQPTEMPKPIY	ANKRD53	361	Q8N9V6
SYLSQLQPPMPKPLS	NOL9	526	Q5SY16
FLPDQMQPQVPPLHY	KLF4	351	O43474
NPFKPVPQLYSPELM	MYO19	76	Q96H55
QKNSLYLMPILPVPS	CFAP65	1721	Q6ZU64
QVSALPPPPMQYIKE	MED7	6	O43513
YPKPDTQQMIPFQPR	CSTF3	581	Q12996
LPQLYKPPTPEMLAY	DIP2B	1141	Q9P265
AQALPGQMLYTQPPL	MED15	331	Q96RN5
PLMTPLDVNQLQFPP	NSG1	26	P42857
LRQYLPPKCMQEIPQ	MLKL	176	Q8NB16
MQPVPAAYPLPNQLT	FOXB1	191	Q99853
LARYPVKPPPEEQQM	RIMS1	361	Q86UR5
LLYLPLKPPNMFPST	CPLANE1	2361	Q9H799
LKPRLGMTLQPQPYL	CYP2R1	481	Q6VVX0
PLHFQLPPQMYKPEQ	KANSL2	361	Q9H9L4
LPPQMYKPEQVLSVP	KANSL2	366	Q9H9L4
MPPNASLLINPLQFP	HEPACAM2	101	A8MVW5
PLQKRMSPLNVYPPG	USH2A	5081	O75445
PKLPMPYITINNLNP	PSG6	236	Q00889
QRPYQMPQLPVAVPQ	TANC2	1586	Q9HCD6
KYNSVIPMRPLNNPL	TICAM2	166	Q86XR7
MFAPLKTLPSQYLPP	MED13	916	Q9UHV7
PAPNQYQMPLLLGPN	ODF3L1	156	Q8IXM7
LQQPENPKKLPYMAP	SLC7A14	616	Q8TBB6
MQRYGPPPSYPNLKI	SF3B2	636	Q13435
QALGMQPYPPLEVPN	ZNF341	236	Q9BYN7
MILDPQQKLRPVPPY	ZNF618	806	Q5T7W0
PAFPLPYAQLQAMPA	HGS	561	O14964
MDLLPPKPKYNPLRN	SHC1	1	P29353
ILPPQRAPNLYMVPQ	MYOF	1281	Q9NZM1