Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

SLC37A1 GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 XKR9 SLC16A4 SLC12A9 ABCA6 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G ATP13A3 SLC5A12 SLC4A3 ABCA10 SLC2A1 RYR2 SLC4A2 GABRR3

5.44e-1312897025GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC37A1 GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SLC16A4 SLC12A9 ABCA6 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G ATP13A3 SLC5A12 SLC4A3 ABCA10 SLC2A1 RYR2 SLC4A2 GABRR3

6.66e-1311807024GO:0022857
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

ELOVL4 NPFFR2 GABRG3 GABRR1 GABRR2 OR5T1 OR5T3 CYSLTR2 TAS2R13 TAS2R14 OR2M2 OR10G3 OR2AT4 OR5B2 LPAR6 OR2G3 OR2Y1 OR4Q3 PTCH2 OR5T2 OR4D6 OR4F21 OR4K3 GABRR3 OR4F6

1.59e-1213537025GO:0004888
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC37A1 GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G SLC5A12 SLC4A3 RYR2 SLC4A2 GABRR3

8.36e-127587019GO:0015318
GeneOntologyMolecularFunctionG protein-coupled receptor activity

ELOVL4 NPFFR2 OR5T1 OR5T3 CYSLTR2 TAS2R13 TAS2R14 OR2M2 OR10G3 OR2AT4 OR5B2 LPAR6 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

1.34e-118847020GO:0004930
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G ATP13A3 SLC5A12 SLC4A3 RYR2 SLC4A2 GABRR3

1.82e-117937019GO:0015075
GeneOntologyMolecularFunctionolfactory receptor activity

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

2.48e-104317014GO:0004984
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2 GABRR3

6.09e-094597013GO:0005216
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC37A1 GABRG3 GABRR1 GABRR2 SLC12A9 SLC34A2 SLC4A3 SLC4A2 GABRR3

8.33e-09171709GO:0015103
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN11A SCN1A SCN2A SCN3A CACNA1G

2.84e-0826705GO:0005248
GeneOntologyMolecularFunctionchannel activity

GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2 GABRR3

2.99e-085257013GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2 GABRR3

3.05e-085267013GO:0022803
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G SLC5A12 RYR2

6.91e-084657012GO:0046873
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SLC34A2

1.35e-0714704GO:0031402
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

GABRG3 GABRR1 GABRR2 SLC12A9 SLC4A3 SLC4A2 GABRR3

2.75e-07125707GO:0015108
GeneOntologyMolecularFunctionGABA-gated chloride ion channel activity

GABRG3 GABRR1 GABRR2 GABRR3

4.08e-0718704GO:0022851
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G ATP13A3 SLC5A12 RYR2

4.49e-076647013GO:0008324
GeneOntologyMolecularFunctionGABA-A receptor activity

GABRG3 GABRR1 GABRR2 GABRR3

5.16e-0719704GO:0004890
GeneOntologyMolecularFunctionGABA receptor activity

GABRG3 GABRR1 GABRR2 GABRR3

9.66e-0722704GO:0016917
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GABRG3 GABRR1 GABRR2 SLC12A9 SLC4A3 SLC4A2 GABRR3

9.90e-07151707GO:0008509
GeneOntologyMolecularFunctionsodium channel activity

SCN11A SCN1A SCN2A SCN3A CACNA1G

1.05e-0652705GO:0005272
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G SLC5A12 RYR2

1.67e-066277012GO:0022890
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SLC34A2

1.95e-0626704GO:0031420
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN11A SCN1A SCN2A SCN3A SLC34A2 CACNA1G SLC5A12

2.27e-06171707GO:0015081
GeneOntologyMolecularFunctiongated channel activity

GABRG3 GABRR1 GABRR2 TMC1 SCN1A SCN2A CACNA1G RYR2 GABRR3

2.44e-06334709GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SCN11A TMC1 PKD2L2 SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2

3.03e-06343709GO:0005261
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC37A1 SLC16A4 SLC12A9 ABCA6 SLC34A2 ATP13A3 SLC5A12 SLC4A3 ABCA10 SLC4A2

6.06e-064777010GO:0022804
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GABRG3 GABRR1 GABRR2 GABRR3

2.82e-0550704GO:0099095
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC37A1 SLC16A4 SLC12A9 SLC34A2 SLC5A12 SLC4A3 SLC4A2

7.90e-05296707GO:0015291
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GABRG3 GABRR1 GABRR2 GABRR3

7.98e-0565704GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GABRG3 GABRR1 GABRR2 GABRR3

7.98e-0565704GO:0022824
GeneOntologyMolecularFunctioncalcium channel activity

TMC1 PKD2L2 TRPC1 CACNA1G RYR2

9.00e-05129705GO:0005262
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GABRG3 GABRR1 GABRR2 GABRR3

1.55e-0477704GO:0005230
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TMC1 PKD2L2 TRPC1 CACNA1G RYR2

1.89e-04151705GO:0015085
GeneOntologyMolecularFunctionsolute:inorganic anion antiporter activity

SLC37A1 SLC4A3 SLC4A2

1.90e-0432703GO:0005452
GeneOntologyMolecularFunctionchloride channel activity

GABRG3 GABRR1 GABRR2 GABRR3

2.37e-0486704GO:0005254
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GABRG3 GABRR1 GABRR2 GABRR3

4.21e-04100704GO:0030594
GeneOntologyMolecularFunctionmonoatomic anion channel activity

GABRG3 GABRR1 GABRR2 GABRR3

4.71e-04103704GO:0005253
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC37A1 SLC16A4 SLC5A12 SLC4A3 SLC2A1 SLC4A2

5.66e-04293706GO:0008514
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GABRG3 GABRR1 GABRR2 RYR2 GABRR3

5.83e-04193705GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GABRG3 GABRR1 GABRR2 RYR2 GABRR3

6.39e-04197705GO:0022834
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC12A9 SLC34A2 ATP13A3 SLC5A12 SLC4A3 SLC4A2

6.52e-04301706GO:0022853
GeneOntologyMolecularFunctionABC-type transporter activity

ABCA6 ATP13A3 ABCA10

6.77e-0449703GO:0140359
GeneOntologyMolecularFunctionchloride:bicarbonate antiporter activity

SLC4A3 SLC4A2

9.22e-0413702GO:0140900
GeneOntologyMolecularFunctionbicarbonate:monoatomic anion antiporter activity

SLC4A3 SLC4A2

9.22e-0413702GO:0140829
GeneOntologyMolecularFunctionodorant binding

OR5T1 OR5T3 OR5B2 OR5T2

1.03e-03127704GO:0005549
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A

1.59e-0317702GO:0099508
GeneOntologyMolecularFunctionsymporter activity

SLC16A4 SLC12A9 SLC34A2 SLC5A12

1.91e-03150704GO:0015293
GeneOntologyMolecularFunctionphosphate transmembrane transporter activity

SLC37A1 SLC34A2

3.18e-0324702GO:0005315
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

TMC1 SCN1A SCN2A CACNA1G

3.83e-03182704GO:0005244
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC16A4 SLC5A12 SLC2A1

3.90e-0390703GO:0008028
GeneOntologyMolecularFunctionvoltage-gated channel activity

TMC1 SCN1A SCN2A CACNA1G

3.99e-03184704GO:0022832
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R13 TAS2R14

4.02e-0327702GO:0033038
GeneOntologyMolecularFunctionlipid transporter activity

XKR9 ABCA6 ABCA10 SLC2A1

4.98e-03196704GO:0005319
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC4A3 SLC4A2

5.61e-0332702GO:0015106
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R13 TAS2R14

5.96e-0333702GO:0008527
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCA6 ATP13A3 ABCA10

6.64e-03109703GO:0042626
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A9 SLC34A2 SLC5A12

8.45e-03119703GO:0015294
GeneOntologyMolecularFunctioncalmodulin binding

WFS1 SCN2A SCN3A RYR2

8.69e-03230704GO:0005516
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

TMC1 CACNA1G

1.14e-0246702GO:0005245
GeneOntologyMolecularFunctionantiporter activity

SLC37A1 SLC4A3 SLC4A2

1.26e-02138703GO:0015297
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GABRG3 GABRR2

1.71e-0257702GO:1904315
GeneOntologyBiologicalProcessdetection of stimulus

ELOVL4 NPFFR2 OR5T1 OR5T3 SCN11A TAS2R13 TAS2R14 TMC1 OR2M2 PKD2L2 OR10G3 OR2AT4 OR5B2 SCN1A OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 RYR2 OR4F6

8.81e-177227023GO:0051606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5T1 OR5T3 SCN11A TAS2R13 TAS2R14 TMC1 OR2M2 OR10G3 OR2AT4 OR5B2 SCN1A OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

4.52e-145827019GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5T1 OR5T3 TAS2R13 TAS2R14 OR2M2 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 RYR2 OR4F6

1.34e-125247017GO:0009593
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5T1 OR5T3 TAS2R13 TAS2R14 OR2M2 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

5.28e-124857016GO:0050907
GeneOntologyBiologicalProcesssensory perception

GABRR2 OR5T1 OR5T3 SCN11A TAS2R13 TAS2R14 TMC1 OR2M2 OR10G3 OR2AT4 WFS1 OR5B2 SCN1A OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

2.99e-1110727021GO:0007600
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5T1 OR5T3 TAS2R13 TAS2R14 OR2M2 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

3.18e-115477016GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

1.68e-104327014GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

4.40e-104657014GO:0007608
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

NPFFR2 OR5T1 OR5T3 SCN11A CYSLTR2 TAS2R13 TAS2R14 OR2M2 OR10G3 OR2AT4 OR5B2 LPAR6 TRPC1 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

3.65e-0913957021GO:0007186
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC37A1 GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G SLC4A3 RYR2 SLC4A2 GABRR3

5.20e-0910177018GO:0098660
GeneOntologyBiologicalProcessinorganic anion transport

SLC37A1 GABRG3 GABRR1 GABRR2 SLC12A9 SLC34A2 SLC4A3 SLC4A2 GABRR3

9.89e-09180709GO:0015698
GeneOntologyBiologicalProcessmonoatomic ion transport

GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SLC12A9 WFS1 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G ATP13A3 SLC5A12 SLC4A3 RYR2 SLC4A2 GABRR3

1.68e-0813747020GO:0006811
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC37A1 GABRG3 GABRR1 GABRR2 SLC12A9 SLC4A3 SLC4A2 GABRR3

1.73e-08134708GO:0098661
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN11A SCN1A SCN2A SCN3A CACNA1G SLC4A3 RYR2

1.80e-0887707GO:0086001
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

GABRG3 GABRR1 GABRR2 SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G ATP13A3 SLC4A3 RYR2 SLC4A2 GABRR3

2.16e-0811157018GO:0034220
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN11A SCN1A SCN2A SCN3A CACNA1G RYR2

6.50e-0862706GO:0086002
GeneOntologyBiologicalProcesschloride transmembrane transport

GABRG3 GABRR1 GABRR2 SLC12A9 SLC4A3 SLC4A2 GABRR3

1.04e-07112707GO:1902476
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN11A SCN1A SCN2A SCN3A CACNA1G

1.35e-0736705GO:0086010
GeneOntologyBiologicalProcesschloride transport

GABRG3 GABRR1 GABRR2 SLC12A9 SLC4A3 SLC4A2 GABRR3

2.60e-07128707GO:0006821
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN11A SCN1A SCN2A SCN3A CACNA1G RYR2

7.42e-0793706GO:0086003
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

GABRG3 GABRR1 GABRR2 SLC12A9 SLC4A3 SLC4A2 GABRR3

8.73e-07153707GO:0098656
GeneOntologyBiologicalProcessneuronal action potential

SCN11A SCN1A SCN2A SCN3A CACNA1G

2.35e-0663705GO:0019228
GeneOntologyBiologicalProcessregulation of membrane potential

GABRG3 GABRR1 GABRR2 SCN11A SCN1A SCN2A SCN3A CACNA1G SLC4A3 RYR2 GABRR3

2.67e-065597011GO:0042391
GeneOntologyBiologicalProcessmonoatomic anion transport

GABRG3 GABRR1 GABRR2 SLC12A9 SLC4A3 SLC4A2 GABRR3

2.89e-06183707GO:0006820
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN11A SCN1A SCN2A SCN3A CACNA1G RYR2

4.60e-06127706GO:0070252
GeneOntologyBiologicalProcessaction potential

SCN11A SCN1A SCN2A SCN3A CACNA1G SLC4A3 RYR2

5.36e-06201707GO:0001508
GeneOntologyBiologicalProcessgamma-aminobutyric acid signaling pathway

GABRG3 GABRR1 GABRR2 GABRR3

5.88e-0635704GO:0007214
GeneOntologyBiologicalProcessheart contraction

SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G SLC4A3 RYR2

7.50e-06298708GO:0060047
GeneOntologyBiologicalProcessheart process

SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G SLC4A3 RYR2

9.77e-06309708GO:0003015
GeneOntologyBiologicalProcessactin filament-based movement

SCN11A SCN1A SCN2A SCN3A CACNA1G RYR2

1.34e-05153706GO:0030048
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN11A SCN1A SCN2A SCN3A CACNA1G RYR2

2.20e-05167706GO:0060048
GeneOntologyBiologicalProcessmetal ion transport

SCN11A TMC1 PKD2L2 SLC12A9 WFS1 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G SLC5A12 RYR2

2.74e-0510007013GO:0030001
GeneOntologyBiologicalProcessmonoatomic cation transport

SCN11A TMC1 PKD2L2 SLC12A9 WFS1 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G ATP13A3 SLC5A12 RYR2

2.85e-0511577014GO:0006812
GeneOntologyBiologicalProcessdetection of abiotic stimulus

ELOVL4 NPFFR2 SCN11A TMC1 PKD2L2 SCN1A

2.86e-05175706GO:0009582
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN11A SCN1A SCN2A SCN3A CACNA1G

3.94e-05112705GO:0019226
GeneOntologyBiologicalProcesssodium ion transport

SCN11A SCN1A SCN2A SCN3A SLC34A2 CACNA1G SLC5A12

4.06e-05275707GO:0006814
GeneOntologyBiologicalProcessmembrane depolarization

SCN11A SCN1A SCN2A SCN3A CACNA1G

5.71e-05121705GO:0051899
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G ATP13A3 RYR2

7.07e-059427012GO:0098655
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SCN11A SCN1A SCN2A SCN3A SLC34A2 CACNA1G

7.50e-05208706GO:0035725
GeneOntologyBiologicalProcessstriated muscle contraction

SCN11A SCN1A SCN2A SCN3A CACNA1G RYR2

9.47e-05217706GO:0006941
GeneOntologyBiologicalProcessdetection of mechanical stimulus

SCN11A TMC1 PKD2L2 SCN1A

1.23e-0475704GO:0050982
GeneOntologyBiologicalProcessmembrane lipid metabolic process

ELOVL4 PIGN ORMDL1 PIGA ITGB8 CERS4

1.27e-04229706GO:0006643
GeneOntologyBiologicalProcesscirculatory system process

SCN11A PLVAP SCN1A TRPC1 SCN2A SCN3A CACNA1G SLC4A3 SLC2A1 RYR2

1.74e-047337010GO:0003013
GeneOntologyBiologicalProcessresponse to mechanical stimulus

SCN11A TMC1 PKD2L2 SCN1A SLC2A1 RYR2

1.92e-04247706GO:0009612
GeneOntologyBiologicalProcessmembrane lipid biosynthetic process

ELOVL4 PIGN ORMDL1 PIGA CERS4

1.95e-04157705GO:0046467
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SCN11A TMC1 PKD2L2 SLC12A9 SCN1A TRPC1 SCN2A SCN3A SLC34A2 CACNA1G RYR2

2.59e-049227011GO:0098662
GeneOntologyBiologicalProcessdetection of external stimulus

ELOVL4 SCN11A TMC1 PKD2L2 SCN1A

3.05e-04173705GO:0009581
GeneOntologyBiologicalProcessblood circulation

SCN11A PLVAP SCN1A TRPC1 SCN2A SCN3A CACNA1G SLC4A3 RYR2

3.32e-04648709GO:0008015
GeneOntologyBiologicalProcesscardiac conduction

TRPC1 CACNA1G SLC4A3 RYR2

3.73e-04100704GO:0061337
GeneOntologyBiologicalProcessmuscle contraction

SCN11A SCN1A SCN2A SCN3A CACNA1G EMD RYR2

4.10e-04400707GO:0006936
GeneOntologyBiologicalProcessSA node cell to atrial cardiac muscle cell signaling

CACNA1G RYR2

5.02e-0410702GO:0086018
GeneOntologyBiologicalProcessSA node cell action potential

CACNA1G RYR2

5.02e-0410702GO:0086015
GeneOntologyBiologicalProcessSA node cell to atrial cardiac muscle cell communication

CACNA1G RYR2

6.12e-0411702GO:0086070
GeneOntologyBiologicalProcessERAD pathway

FAF2 RNF103 WFS1 MARCHF6

7.20e-04119704GO:0036503
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

CACNA1G RYR2

7.33e-0412702GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

CACNA1G RYR2

7.33e-0412702GO:0086016
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

SCN11A TMC1 SCN1A

9.61e-0457703GO:0050974
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

CACNA1G RYR2

1.16e-0315702GO:0086067
GeneOntologyBiologicalProcessrenal system process

SCN11A WFS1 KIRREL1 HAS2

1.66e-03149704GO:0003014
GeneOntologyBiologicalProcesscalcium ion transport

SCN11A TMC1 PKD2L2 WFS1 TRPC1 CACNA1G RYR2

1.68e-03509707GO:0006816
GeneOntologyBiologicalProcesstype B pancreatic cell apoptotic process

WFS1 RYR2

1.68e-0318702GO:0097050
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN11A SCN1A SCN2A SCN3A CACNA1G

2.52e-0917725GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN11A SCN1A SCN2A SCN3A CACNA1G

4.69e-0829725GO:0034706
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

ELOVL4 SLC37A1 PIGN OR5T3 ORMDL1 PIGA FAF2 OR2M2 RNF103 RPN1 WFS1 MARCHF6 TMEM39A EMD STARD3NL HAS2 SPPL2B CERS4 RYR2

5.19e-0812997219GO:0098827
GeneOntologyCellularComponentmonoatomic ion channel complex

GABRG3 GABRR1 GABRR2 SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2 GABRR3

6.58e-083787211GO:0034702
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

ELOVL4 SLC37A1 PIGN OR5T3 ORMDL1 PIGA FAF2 OR2M2 RNF103 RPN1 WFS1 MARCHF6 TMEM39A EMD STARD3NL HAS2 SPPL2B CERS4 RYR2

7.27e-0813277219GO:0042175
GeneOntologyCellularComponentendoplasmic reticulum membrane

ELOVL4 SLC37A1 PIGN OR5T3 ORMDL1 PIGA FAF2 OR2M2 RNF103 RPN1 WFS1 MARCHF6 TMEM39A STARD3NL HAS2 SPPL2B CERS4 RYR2

2.64e-0712937218GO:0005789
GeneOntologyCellularComponenttransporter complex

GABRG3 GABRR1 GABRR2 SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G SLC2A1 RYR2 GABRR3

3.57e-075507212GO:1990351
GeneOntologyCellularComponentGABA-A receptor complex

GABRG3 GABRR1 GABRR2 GABRR3

4.82e-0719724GO:1902711
GeneOntologyCellularComponentGABA receptor complex

GABRG3 GABRR1 GABRR2 GABRR3

7.41e-0721724GO:1902710
GeneOntologyCellularComponenttransmembrane transporter complex

GABRG3 GABRR1 GABRR2 SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2 GABRR3

1.65e-065237211GO:1902495
GeneOntologyCellularComponentcation channel complex

SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2

1.64e-05235727GO:0034703
GeneOntologyCellularComponentmembrane protein complex

GABRG3 GABRR1 GABRR2 SCN11A PIGA FAF2 RPN1 SCN1A TRPC1 SCN2A SCN3A MARCHF6 CACNA1G ITGB8 RYR2 GABRR3

3.96e-0514987216GO:0098796
GeneOntologyCellularComponentchloride channel complex

GABRG3 GABRR1 GABRR2 GABRR3

4.45e-0557724GO:0034707
GeneOntologyCellularComponentGABA-ergic synapse

GABRG3 GABRR1 GABRR2 LRRTM2 GABRR3

2.56e-04164725GO:0098982
GeneOntologyCellularComponentsynaptic membrane

GABRG3 GABRR1 GABRR2 SCN11A SCN1A SCN2A LRRTM2 GABRR3

8.70e-04583728GO:0097060
GeneOntologyCellularComponentendoplasmic reticulum protein-containing complex

PIGA FAF2 RPN1 MARCHF6

9.16e-04125724GO:0140534
GeneOntologyCellularComponentintercalated disc

SCN1A SCN2A SLC2A1

1.67e-0368723GO:0014704
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A

2.14e-0320722GO:0033268
GeneOntologyCellularComponentcell-cell contact zone

SCN1A SCN2A SLC2A1

4.20e-0394723GO:0044291
GeneOntologyCellularComponentsarcolemma

SCN1A SCN2A SLC2A1 RYR2

4.20e-03190724GO:0042383
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A

4.47e-0329722GO:0043194
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN3A SLC2A1

7.34e-0627254HP:0011171
HumanPhenoAortopulmonary collateral arteries

PIGA SCN1A SCN2A

4.57e-0515253HP:0031834
HumanPhenoFocal emotional seizure with laughing

PIGA SCN1A SCN2A

6.79e-0517253HP:0010821
HumanPhenoFocal emotional seizure

PIGA SCN1A SCN2A

8.12e-0518253HP:0025613
HumanPhenoTremor

ELOVL4 PIGN PIGA WFS1 SCN1A DNAJC30 SCN2A SCN3A MARCHF6 CACNA1G SLC2A1

9.38e-056392511HP:0001337
MousePhenodecreased Sertoli cell number

WFS1 CNOT7 SLC4A2

8.71e-0612493MP:0005250
MousePhenoabnormal nervous system electrophysiology

GABRR1 SCN11A SCN1A TRPC1 SCN2A CACNA1G SLC2A1 RYR2

1.68e-05329498MP:0002272
MousePhenoabnormal afterhyperpolarization

SCN11A CACNA1G RYR2

2.66e-0517493MP:0003412
MousePhenoabnormal response to novelty

ELOVL4 PKD2L2 WFS1 SCN1A DNAJC30 TRPC1 SCN2A MARCHF6 CACNA1G ATP13A3 NEMP2

6.83e-057874911MP:0003107
MousePhenodecreased paired-pulse ratio

SCN1A RYR2

7.19e-054492MP:0014253
MousePhenoabnormal action potential

SCN11A SCN1A SCN2A CACNA1G RYR2

9.85e-05133495MP:0005402
MousePhenodecreased heart right ventricle muscle contractility

EMD RYR2

1.79e-046492MP:0031634
MousePhenoabnormal channel response

SCN11A SCN2A CACNA1G

2.05e-0433493MP:0003484
MousePhenoabnormal single cell response

SCN11A TRPC1 CACNA1G

2.45e-0435493MP:0003463
MousePhenoabnormal paired-pulse ratio

SCN1A RYR2

2.50e-047492MP:0014252
MousePhenoventricular fibrillation

SCN1A RYR2

2.50e-047492MP:0006110
MousePhenoincreased locomotor activity

PKD2L2 WFS1 SCN1A SCN2A SLC2A1

3.83e-04178495MP:0031391
DomainOlfact_rcpt

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

2.09e-093937013IPR000725
DomainGPCR_Rhodpsn_7TM

NPFFR2 OR5T1 OR5T3 CYSLTR2 OR2M2 OR10G3 OR2AT4 OR5B2 LPAR6 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

2.57e-096707016IPR017452
Domain7tm_1

NPFFR2 OR5T1 OR5T3 CYSLTR2 OR2M2 OR10G3 OR2AT4 OR5B2 LPAR6 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

2.98e-096777016PF00001
DomainG_PROTEIN_RECEP_F1_1

NPFFR2 OR5T1 OR5T3 CYSLTR2 OR2M2 OR10G3 OR2AT4 OR5B2 LPAR6 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

3.53e-096857016PS00237
DomainG_PROTEIN_RECEP_F1_2

NPFFR2 OR5T1 OR5T3 CYSLTR2 OR2M2 OR10G3 OR2AT4 OR5B2 LPAR6 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

3.99e-096917016PS50262
DomainGPCR_Rhodpsn

NPFFR2 OR5T1 OR5T3 CYSLTR2 OR2M2 OR10G3 OR2AT4 OR5B2 LPAR6 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

4.08e-096927016IPR000276
DomainNa_channel_asu

SCN11A SCN1A SCN2A SCN3A

3.73e-0810704IPR001696
DomainNa_trans_assoc

SCN11A SCN1A SCN2A SCN3A

3.73e-0810704IPR010526
DomainNa_trans_assoc

SCN11A SCN1A SCN2A SCN3A

3.73e-0810704PF06512
DomainIon_trans_dom

SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2

2.29e-07114707IPR005821
DomainIon_trans

SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2

2.29e-07114707PF00520
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A

1.00e-066703PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A

1.00e-066703IPR024583
DomainGABAA/Glycine_rcpt

GABRG3 GABRR1 GABRR2 GABRR3

1.52e-0623704IPR006028
DomainChannel_four-helix_dom

SCN11A SCN1A SCN2A SCN3A CACNA1G

2.30e-0657705IPR027359
Domain-

SCN11A SCN1A SCN2A SCN3A CACNA1G

2.30e-06577051.20.120.350
DomainGABAAa_rho_rcpt

GABRR1 GABRR2

1.38e-052702IPR008057
DomainNeurotransmitter_ion_chnl_CS

GABRG3 GABRR1 GABRR2 GABRR3

2.40e-0545704IPR018000
DomainNeur_chan_memb

GABRG3 GABRR1 GABRR2 GABRR3

2.62e-0546704PF02932
DomainNeur_chan_LBD

GABRG3 GABRR1 GABRR2 GABRR3

2.86e-0547704PF02931
DomainNeur_channel

GABRG3 GABRR1 GABRR2 GABRR3

2.86e-0547704IPR006201
DomainNeur_chan_lig-bd

GABRG3 GABRR1 GABRR2 GABRR3

2.86e-0547704IPR006202
DomainNEUROTR_ION_CHANNEL

GABRG3 GABRR1 GABRR2 GABRR3

2.86e-0547704PS00236
DomainNeurotrans-gated_channel_TM

GABRG3 GABRR1 GABRR2 GABRR3

2.86e-0547704IPR006029
Domain-

GABRG3 GABRR1 GABRR2 GABRR3

2.86e-05477042.70.170.10
DomainAnion_exchange_CS

SLC4A3 SLC4A2

4.14e-053702IPR018241
DomainAnion_exchange

SLC4A3 SLC4A2

1.37e-045702IPR001717
DomainANION_EXCHANGER_2

SLC4A3 SLC4A2

2.87e-047702PS00220
DomainANION_EXCHANGER_1

SLC4A3 SLC4A2

2.87e-047702PS00219
DomainBand3_cytoplasmic_dom

SLC4A3 SLC4A2

4.90e-049702IPR013769
DomainBand_3_cyto

SLC4A3 SLC4A2

4.90e-049702PF07565
Domain-

SLC4A3 SLC4A2

4.90e-0497023.40.1100.10
DomainPTrfase/Anion_transptr

SLC4A3 SLC4A2

6.11e-0410702IPR016152
DomainHCO3_cotransp

SLC4A3 SLC4A2

6.11e-0410702PF00955
DomainHCO3_transpt_euk

SLC4A3 SLC4A2

6.11e-0410702IPR003020
DomainHCO3_transpt_C

SLC4A3 SLC4A2

6.11e-0410702IPR011531
DomainABC_A

ABCA6 ABCA10

8.92e-0412702IPR026082
DomainIQ

SCN1A SCN2A SCN3A

3.49e-0381703SM00015
DomainTAS2R

TAS2R13 TAS2R14

4.25e-0326702PF05296
DomainT2R

TAS2R13 TAS2R14

4.25e-0326702IPR007960
DomainIQ_motif_EF-hand-BS

SCN1A SCN2A SCN3A

4.69e-0390703IPR000048
DomainIQ

SCN1A SCN2A SCN3A

5.14e-0393703PS50096
PathwayREACTOME_SENSORY_PERCEPTION

OR5T1 OR5T3 TAS2R13 TAS2R14 TMC1 OR2M2 OR10G3 OR2AT4 OR5B2 SCN2A SCN3A OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

2.69e-116366419M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4K3 OR4F6

3.93e-094176414M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F6

1.23e-063896411M14091
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN11A SCN1A SCN2A SCN3A

1.11e-0531644M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN11A SCN1A SCN2A SCN3A

1.26e-0532644M27455
PathwayREACTOME_CARDIAC_CONDUCTION

SCN11A SCN1A TRPC1 SCN2A SCN3A RYR2

2.65e-05130646M27454
PathwayREACTOME_MUSCLE_CONTRACTION

SCN11A SCN1A TRPC1 SCN2A SCN3A CACNA1G RYR2

3.59e-05203647M5485
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TAS2R13 TAS2R14 SCN2A SCN3A

5.95e-0547644M42524
PathwayREACTOME_GABA_RECEPTOR_ACTIVATION

GABRG3 GABRR1 GABRR2 GABRR3

1.56e-0460644M976
PathwayREACTOME_GABA_RECEPTOR_ACTIVATION

GABRG3 GABRR1 GABRR2 GABRR3

1.56e-0460644MM15708
PathwayWP_DRAVET_SYNDROME

SCN1A SCN2A SCN3A

2.70e-0428643M45519
PathwayWP_GPCRS_ODORANT

OR5T1 TAS2R13 TAS2R14 OR2Y1 OR5T2

7.22e-04157645MM15872
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A3 SLC4A2

8.92e-0410642M27335
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A3 SLC4A2

8.92e-0410642MM15073
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

NPFFR2 GABRG3 GABRR1 GABRR2 CYSLTR2 LPAR6

1.43e-03272646M13380
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC34A2 SLC5A12 SLC4A3 SLC4A2

1.45e-03108644M823
PathwayWP_PRADERWILLI_AND_ANGELMAN_SYNDROME

GABRG3 GABRR1 GABRR2 GABRR3

1.50e-03109644M39542
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC34A2 SLC5A12 SLC4A3 SLC4A2

1.50e-03109644MM15074
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

TRPC1 RYR2

1.53e-0313642M39589
PathwayREACTOME_SENSORY_PERCEPTION

TAS2R13 TAS2R14 OR10G3 OR2AT4 OR4Q3

1.69e-03190645MM15687
PathwayREACTOME_L1CAM_INTERACTIONS

SCN11A SCN1A SCN2A SCN3A

2.21e-03121644M872
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

5.70e-12340721211875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

5.70e-12340721211802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

6.32e-12343721232295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5T1 OR5T3 OR2M2 OR10G3 OR2AT4 OR5B2 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4F21 OR4F6

6.99e-12346721214611657
Pubmed

The human olfactory receptor gene family.

OR5T1 OR5T3 OR10G3 OR2AT4 OR5B2 OR2G3 OR2Y1 OR4Q3 OR5T2 OR4D6 OR4K3 OR4F6

1.17e-09541721214983052
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN11A SCN1A SCN2A SCN3A

2.11e-09972416382098
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

8.51e-09372312610651
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

8.51e-09372323859570
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

8.51e-09372318784617
Pubmed

Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.

GABRR1 GABRR2 GABRR3

8.51e-09372310542332
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

8.51e-09372317544618
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

8.51e-09372314973256
Pubmed

GABAC receptors are functionally expressed in the intermediate zone and regulate radial migration in the embryonic mouse neocortex.

GABRR1 GABRR2 GABRR3

8.51e-09372320123002
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A

3.40e-08472317537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A

3.40e-08472335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A

3.40e-08472329578003
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

3.40e-08472335801810
Pubmed

Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.

GABRR1 GABRR2 GABRR3

3.40e-08472320820800
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

3.40e-0847238974318
Pubmed

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

GABRG3 GABRR1 GABRR2 GABRR3

5.05e-081872419078961
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

8.48e-0857231679748
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A

8.48e-0857238812438
Pubmed

ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.

GABRR1 GABRR2 GABRR3

8.48e-08572312431995
Pubmed

PNUTS forms a trimeric protein complex with GABA(C) receptors and protein phosphatase 1.

GABRR1 GABRR2 GABRR3

8.48e-08572318325784
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

8.48e-08572324337656
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A

1.69e-07672323652591
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A

7.08e-07972315746173
Pubmed

Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder.

GABRG3 GABRR1 GABRR2

1.01e-061072320583128
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

1.85e-06127238169823
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A

1.85e-061272330175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A

2.40e-061372315123669
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A

3.80e-06157239726281
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

4.23e-06272229649454
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

4.23e-06272220346423
Pubmed

The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.

GABRR1 GABRR2

4.23e-0627229153229
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

4.23e-06272210827969
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

4.23e-06272219694741
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

4.23e-06272211245985
Pubmed

Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.

SLC4A3 SLC4A2

4.23e-06272211248201
Pubmed

Elimination of the rho1 subunit abolishes GABA(C) receptor expression and alters visual processing in the mouse retina.

GABRR1 GABRR2

4.23e-06272212019334
Pubmed

Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.

GABRR1 GABRR2

4.23e-06272228660714
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

4.23e-0627221317301
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

4.23e-06272223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

4.23e-06272227153334
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

4.23e-06272233096315
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

4.23e-06272224990319
Pubmed

GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.

GABRR1 GABRR2

4.23e-06272219536785
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

4.23e-06272231439038
Pubmed

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.

SCN1A SCN2A

4.23e-06272226311622
Pubmed

The Brucella abortus Type IV Effector BspA Inhibits MARCH6-Dependent ERAD To Promote Intracellular Growth.

FAF2 MARCHF6

4.23e-06272237129527
Pubmed

Aberrant MCT4 and GLUT1 expression is correlated with early recurrence and poor prognosis of hepatocellular carcinoma after hepatectomy.

SLC16A4 SLC2A1

4.23e-06272230306706
Pubmed

Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome.

SCN1A CACNA1G

4.23e-06272228556246
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

4.23e-06272215249644
Pubmed

Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4.

SLC16A4 SLC2A1

4.23e-06272222153830
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

4.23e-06272227690330
Pubmed

The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.

SCN1A SCN2A

4.23e-06272221377452
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

4.23e-06272223965409
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

4.23e-06272230693367
Pubmed

cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger.

SLC4A3 SLC4A2

4.23e-0627222294114
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR2M2 OR10G3 OR5B2 OR2Y1 OR4D6 OR4K3

6.43e-0621972612213199
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

SCN11A SCN1A SCN3A CACNA1G RYR2

1.07e-0513972516985003
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A

1.27e-05372219284629
Pubmed

Expression and role of GLUT-1, MCT-1, and MCT-4 in malignant pleural mesothelioma.

SLC16A4 SLC2A1

1.27e-05372223187830
Pubmed

Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

SCN1A SCN2A

1.27e-05372228784306
Pubmed

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

SCN1A SCN2A

1.27e-05372232185219
Pubmed

Cloning and characterization of mouse GABA(C) receptor subunits.

GABRR1 GABRR2

1.27e-0537229507960
Pubmed

Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.

SCN1A SCN2A

1.27e-05372232005694
Pubmed

Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.

GABRR1 GABRR2

1.27e-0537229839716
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A

1.27e-05372233895391
Pubmed

Expression and function of bicarbonate/chloride exchangers in the preimplantation mouse embryo.

SLC4A3 SLC4A2

1.27e-0537227592657
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A

1.27e-05372232845893
Pubmed

Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex.

SLC4A3 SLC4A2

1.27e-05372211208611
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A

1.27e-05372228518218
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

1.27e-05372227816501
Pubmed

Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.

SCN1A SCN2A

1.27e-05372219270815
Pubmed

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

SCN2A SCN3A

1.27e-05372216052353
Pubmed

GABAC receptor sensitivity is modulated by interaction with MAP1B.

GABRR1 GABRR2

1.27e-05372211102469
Pubmed

Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.

SCN1A SCN2A

1.27e-05372225155934
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A

1.27e-05372217928448
Pubmed

GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions.

SLC16A4 SLC2A1

1.27e-05372235615882
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

SLC37A1 CYSLTR2 WFS1 DNAJC30 CD37 MARCHF6 STARD3NL SLC4A3 SLC2A1

1.37e-0569772928298427
Pubmed

Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.

SCN1A SCN2A SCN3A XDH

1.48e-05717248751373
Pubmed

Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.

GABRG3 GABRR1 GABRR2 GABRR3

2.49e-058172422723691
Pubmed

Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.

SLC4A3 SLC4A2

2.53e-05472211842009
Pubmed

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

SCN1A SCN2A

2.53e-05472226637798
Pubmed

Developmentally regulated expression of GABA receptor rho1 and rho2 subunits, L7 and cone-rod homeobox (CRX) genes in mouse retina.

GABRR1 GABRR2

2.53e-05472211520487
Pubmed

A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival.

ABCA6 ABCA10

2.53e-05472225294155
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A

2.53e-05472221156207
Pubmed

Glycolysis-related protein expression in thyroid cancer.

SLC16A4 SLC2A1

2.53e-05472228347233
Pubmed

Defining the membrane proteome of NK cells.

SLC37A1 PIGN PIGA RPN1 CD37 MARCHF6 CNOT7 ATP13A3 EMD STARD3NL SLC4A2

2.71e-051168721119946888
Pubmed

GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression.

SLC16A4 SLC2A1

4.21e-05572221870331
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN11A SCN3A

4.21e-05572222875929
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A

4.21e-05572217724025
Pubmed

Ameloblast Modulation and Transport of Cl⁻, Na⁺, and K⁺ during Amelogenesis.

SLC34A2 SLC4A2

6.31e-05672226403673
Pubmed

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

SCN11A SCN2A

6.31e-05672217513486
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN11A SCN3A

6.31e-05672223711479
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

TRPC1 CACNA1G RYR2

6.81e-053872330786075
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

LAPTM4A FAF2 WFS1 ATP13A3 EMD SLC2A1 SLC4A2

7.91e-0549972722810586
Pubmed

Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4.

GABRR1 GABRR2

8.82e-0577221315307
Pubmed

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells.

GABRR1 GABRR2

8.82e-0577228940147
InteractionTTYH1 interactions

PIGN ORMDL1 PIGA SLC12A9 DNAJC30 TMEM39A SPPL2B CERS4 SLC4A2

3.24e-07300629int:TTYH1
InteractionKRTCAP2 interactions

PIGN RPN1 MARCHF6 ATP13A3 SLC4A2

2.79e-0672625int:KRTCAP2
InteractionABCA6 interactions

ABCA6 DNAJC30 ABCA10

3.28e-0610623int:ABCA6
InteractionCCR6 interactions

ELOVL4 PIGN ATP13A3 SPPL2B SLC4A2

7.96e-0689625int:CCR6
InteractionVKORC1L1 interactions

PIGN RPN1 SERINC2 ATP13A3 SPPL2B

1.34e-0599625int:VKORC1L1
InteractionKDELR3 interactions

LPAR6 SPPL2B SLC2A1 SLC4A2

1.82e-0551624int:KDELR3
InteractionSTARD3NL interactions

WFS1 ATP13A3 STARD3NL SLC4A2

1.97e-0552624int:STARD3NL
InteractionSIGMAR1 interactions

PIGN SERINC2 SPPL2B SLC2A1 SLC4A2

3.01e-05117625int:SIGMAR1
InteractionGPR89A interactions

PIGN RPN1 ATP13A3 EMD SPPL2B

3.40e-05120625int:GPR89A
InteractionZDHHC12 interactions

ELOVL4 PIGA SLC12A9 ATP13A3 TMEM39A

3.82e-05123625int:ZDHHC12
InteractionBRI3BP interactions

PIGN RPN1 ATP13A3 EMD SPPL2B

3.98e-05124625int:BRI3BP
InteractionCACNA1D interactions

SCN11A SCN1A RYR2

5.36e-0524623int:CACNA1D
InteractionOR10H2 interactions

SLC12A9 ATP13A3 TMEM39A SLC4A2

7.14e-0572624int:OR10H2
InteractionGJD3 interactions

FAF2 RPN1 WFS1 KIRREL1 ATP13A3 EMD SLC2A1 SLC4A2

7.26e-05454628int:GJD3
InteractionDHCR24 interactions

WFS1 ATP13A3 SPPL2B SLC2A1 SLC4A2

8.65e-05146625int:DHCR24
InteractionTMEM63B interactions

ORMDL1 RPN1 SLC34A2 EMD SPPL2B

8.93e-05147625int:TMEM63B
InteractionGPR21 interactions

PIGN SLC12A9 MARCHF6 SLC4A2

1.13e-0481624int:GPR21
InteractionJAGN1 interactions

ELOVL4 RPN1 DNAJC30 SLC34A2 CERS4

1.29e-04159625int:JAGN1
InteractionGABRR2 interactions

GABRR1 GABRR2

1.39e-046622int:GABRR2
InteractionRABL3 interactions

PIGN RPN1 SERINC2 EMD CERS4

1.49e-04164625int:RABL3
InteractionPTH1R interactions

ORMDL1 SLC12A9 SPPL2B SLC4A2

1.56e-0488624int:PTH1R
InteractionGRAMD1A interactions

PKD2L2 RPN1 DNAJC30 ATP13A3 EMD

1.67e-04168625int:GRAMD1A
InteractionHSD3B7 interactions

ELOVL4 FAF2 RPN1 WFS1 ATP13A3 EMD SLC4A2

1.78e-04386627int:HSD3B7
InteractionSLC41A3 interactions

SLC12A9 RPN1 SLC4A2

1.84e-0436623int:SLC41A3
InteractionADGRG5 interactions

SLC12A9 ATP13A3 SPPL2B SLC4A2

1.93e-0493624int:ADGRG5
InteractionPXMP2 interactions

FAF2 RPN1 WFS1 LPAR6 ATP13A3 EMD

2.23e-04281626int:PXMP2
InteractionMS4A15 interactions

SLC12A9 MARCHF6 SLC4A2

2.34e-0439623int:MS4A15
InteractionABCA10 interactions

ABCA6 ABCA10

2.58e-048622int:ABCA10
InteractionSCN4B interactions

SCN1A SCN2A

2.58e-048622int:SCN4B
InteractionGPAT3 interactions

RPN1 EMD SPPL2B SLC2A1

2.75e-04102624int:GPAT3
InteractionVMP1 interactions

FAF2 RPN1 LPAR6 EMD SPPL2B

2.96e-04190625int:VMP1
InteractionPIGU interactions

PIGN RPN1 EMD SPPL2B

2.97e-04104624int:PIGU
InteractionCERS6 interactions

PIGN RPN1 SPPL2B CERS4

2.97e-04104624int:CERS6
InteractionC3orf52 interactions

PIGA SLC12A9 WFS1 DNAJC30 ATP13A3 TMEM39A

3.45e-04305626int:C3orf52
InteractionSLC7A1 interactions

ELOVL4 RPN1 SPPL2B SLC2A1 CERS4

3.49e-04197625int:SLC7A1
InteractionTRARG1 interactions

ELOVL4 NPFFR2 WFS1 SLC34A2

3.80e-04111624int:TRARG1
InteractionSQLE interactions

FAF2 MARCHF6 PTCH2

3.83e-0446623int:SQLE
InteractionATF6 interactions

RPN1 WFS1 EMD SPPL2B

4.64e-04117624int:ATF6
InteractionWFS1 interactions

RPN1 WFS1 EMD STARD3NL

4.79e-04118624int:WFS1
InteractionSCN10A interactions

SCN11A SCN1A

5.03e-0411622int:SCN10A
InteractionTMEM9 interactions

PIGN RPN1 WFS1 ATP13A3 EMD

6.53e-04226625int:TMEM9
InteractionPSEN1 interactions

FAF2 SCN1A CNOT7 SPPL2B RYR2

6.66e-04227625int:PSEN1
InteractionGPAT4 interactions

RPN1 EMD STARD3NL SPPL2B

6.71e-04129624int:GPAT4
InteractionTREX1 interactions

ELOVL4 RPN1 ITGB8

6.84e-0456623int:TREX1
InteractionSERF1B interactions

ELOVL4 CERS4

7.11e-0413622int:SERF1B
InteractionHAS3 interactions

HAS2 SPPL2B

7.11e-0413622int:HAS3
InteractionGPR35 interactions

SLC37A1 ATP13A3 STARD3NL SLC2A1

7.52e-04133624int:GPR35
InteractionTMEM42 interactions

ELOVL4 SLC34A2 SERINC2

7.58e-0458623int:TMEM42
InteractionAUP1 interactions

FAF2 RPN1 ATP13A3 EMD SLC2A1

7.64e-04234625int:AUP1
InteractionCLGN interactions

PIGN RPN1 WFS1 SPPL2B SLC4A2

7.78e-04235625int:CLGN
InteractionNALCN interactions

SCN11A SCN1A

8.27e-0414622int:NALCN
InteractionCMTM5 interactions

ELOVL4 PIGN WFS1 ATP13A3 SLC4A2

8.40e-04239625int:CMTM5
InteractionNPC1 interactions

FAF2 SLC12A9 RPN1 EMD SPPL2B SLC2A1

8.74e-04364626int:NPC1
InteractionCACNA1C interactions

SCN11A SCN1A RYR2

8.79e-0461623int:CACNA1C
InteractionSIDT2 interactions

PIGA SLC12A9 SPPL2B SLC4A2

9.11e-04140624int:SIDT2
InteractionATP6AP1 interactions

SLC34A2 SERINC2 SLC2A1 CERS4

9.11e-04140624int:ATP6AP1
InteractionSTK17B interactions

FAF2 LPAR6 SLC2A1

9.21e-0462623int:STK17B
InteractionITPR1 interactions

RPN1 TRPC1 EMD RYR2

9.35e-04141624int:ITPR1
InteractionSCN11A interactions

SCN11A SCN1A

9.53e-0415622int:SCN11A
InteractionLHFPL5 interactions

ELOVL4 CD37 SLC34A2 CERS4

9.60e-04142624int:LHFPL5
InteractionTXNDC15 interactions

PIGN MARCHF6 SPPL2B

1.01e-0364623int:TXNDC15
InteractionATP6V0D2 interactions

SLC34A2 SERINC2 SLC2A1

1.01e-0364623int:ATP6V0D2
InteractionGABRR1 interactions

GABRR1 GABRR2

1.09e-0316622int:GABRR1
InteractionGPR88 interactions

MARCHF6 ATP13A3

1.09e-0316622int:GPR88
Cytoband11q12.1

OR5T1 OR5T3 OR5B2 OR5T2 OR4D6

5.77e-0616172511q12.1
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5T1 OR5T3 OR5B2 OR5T2 OR4D6

2.16e-04345725chr11q12
Cytoband2q24.3

SCN1A SCN2A

2.87e-04167222q24.3
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN2A SCN3A

1.07e-03127723chr2q24
Cytoband6q15

GABRR1 GABRR2

1.10e-03317226q15
CytobandEnsembl 112 genes in cytogenetic band chr14q11

OR10G3 OR4Q3 OR4K3 LINC00596

1.88e-03332724chr14q11
Cytoband14q11.2

OR10G3 OR4Q3 OR4K3

2.90e-0318072314q11.2
CytobandEnsembl 112 genes in cytogenetic band chr6q15

GABRR1 GABRR2

2.94e-0351722chr6q15
GeneFamilySodium voltage-gated channel alpha subunits

SCN11A SCN1A SCN2A SCN3A

1.19e-0895841203
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRG3 GABRR1 GABRR2 GABRR3

3.56e-0719584563
GeneFamilySolute carriers

SLC37A1 SLC16A4 SLC12A9 SLC34A2 SLC5A12 SLC4A3 SLC2A1 SLC4A2

3.57e-05395588752
GeneFamilyOlfactory receptors, family 4

OR4Q3 OR4D6 OR4F21 OR4K3 OR4F6

5.79e-05129585151
GeneFamilyOlfactory receptors, family 5

OR5T1 OR5T3 OR5B2 OR5T2

4.58e-04112584152
GeneFamilyOlfactory receptors, family 2

OR2M2 OR2AT4 OR2G3 OR2Y1

4.73e-04113584149
GeneFamilyATP binding cassette subfamily A

ABCA6 ABCA10

8.98e-0414582805
GeneFamilyGlycosyl transferases group 1 domain containing|Phosphatidylinositol glycan anchor biosynthesis

PIGN PIGA

2.04e-0321582680
GeneFamilyTransient receptor potential cation channels

PKD2L2 TRPC1

3.62e-0328582249
GeneFamilyTaste 2 receptors

TAS2R13 TAS2R14

6.94e-03395821162
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

XKR9 SCN2A SCN3A XDH SERINC2

1.18e-0518372515d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN2A CD37 SLC4A3 RYR2

1.28e-051867257278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

NPFFR2 GABRG3 SCN2A SCN3A RYR2

1.42e-051907256e92c78799f34b31d098854503c796edb0dc7f80
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG3 SCN1A SCN2A SCN3A RYR2

1.73e-05198725c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG3 SCN1A SCN2A SCN3A RYR2

1.73e-051987256d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRG3 SCN1A SCN2A SCN3A RYR2

1.73e-051987254ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA6 ATP13A3 HAS2 ITGB8 RYR2

1.77e-051997258b86c69aaf60feff53aa782559cfece7342a23de
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA6 CACNA1G HAS2 ABCA10 ITGB8

1.81e-05200725fb53be20392a8309a7393774c774a1b1aec6e676
DrugZonisamide

SCN11A SCN1A SCN2A SCN3A CACNA1G

1.33e-0917695DB00909
Drugsodium

GABRG3 GABRR1 GABRR2 SLC12A9 TRPC1 SCN2A SCN3A SLC34A2 SLC5A12 EMD SLC4A3 SLC2A1 RYR2 SLC4A2

7.43e-079446914CID000000923
Druggabapentin

GABRG3 GABRR1 GABRR2 SCN3A CACNA1G RYR2

1.25e-05169696CID000003446
Drugriluzole

GABRG3 GABRR1 GABRR2 SCN3A CACNA1G RYR2

1.47e-05174696CID000005070
Drughydroxybutyrate

GABRG3 GABRR1 GABRR2 SCN2A SLC5A12

2.62e-05115695CID000010413
DrugBenfotiamine [22457-89-2]; Up 200; 8.6uM; PC3; HT_HG-U133A

GABRG3 PLVAP PKD2L2 SCN3A XDH CACNA1G

2.80e-051956964312_UP
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN11A SCN1A SCN2A SCN3A

5.36e-0910684DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN11A SCN1A SCN2A SCN3A

5.36e-0910684DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN11A SCN1A SCN2A SCN3A

1.26e-0812684DOID:0060170 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A

1.75e-0522683DOID:2030 (implicated_via_orthology)
DiseaseMultiple congenital anomalies-hypotonia-seizures syndrome

PIGN PIGA

3.13e-054682cv:C5191419
Diseasegene methylation measurement

GABRG3 ABCA6

7.80e-056682EFO_0006959
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

1.09e-047682C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

1.09e-047682C0751057
DiseaseN-acetylcarnosine measurement

GABRR1 GABRR2

1.45e-048682EFO_0022101
DiseaseAtaxias, Hereditary

WFS1 SLC2A1

1.45e-048682C0004138
DiseaseFebrile Convulsions

SCN1A SCN2A

1.86e-049682C0009952
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A

1.86e-049682C3502809
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GABRR1 GABRR2 GABRR3

2.00e-0449683DOID:0060037 (implicated_via_orthology)
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A

4.02e-0413682C0751122
DiseaseMMR-related febrile seizures

SCN1A SCN2A

5.39e-0415682EFO_0006519
Diseaseanemia (implicated_via_orthology)

SLC4A3 SLC4A2

5.39e-0415682DOID:2355 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SCN11A SCN1A SCN2A SCN3A

5.55e-04163684DOID:1826 (implicated_via_orthology)
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

6.15e-0416682C0393706
Diseasepartial epilepsy

ELOVL4 SCN1A

6.96e-0417682EFO_0004263
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

7.82e-0418682HP_0002373
Diseasecorneal hysteresis

ABCA6 ABCA10

9.68e-0420682EFO_0010066
DiseaseWest Syndrome

PIGA SCN2A

1.40e-0324682C0037769
DiseaseAutosomal dominant nonsyndromic hearing loss

TMC1 WFS1

2.04e-0329682cv:C5779548
Diseaselevel of Sphingomyelin (d38:1) in blood serum

NPFFR2 CERS4

2.18e-0330682OBA_2045180
Diseaseresponse to tenofovir, creatinine clearance measurement

OR5T1 OR5T3 RYR2

2.23e-03112683EFO_0007934, EFO_0009279

Protein segments in the cluster

PeptideGeneStartEntry
IFAFLISLIFIYETF

SLC4A2

826

P04920
IFAFLISLIFIYETF

SLC4A3

826

P48751
LIFSFVFFYTRLVLF

CERS4

266

Q9HA82
STVFCLFVYLFIFVF

LINC00596

36

Q86U02
ATFFILAFDTLFYLI

ABCA10

311

Q8WWZ4
FFVFSVIFLYIFILF

ATP13A3

1106

Q9H7F0
FIPYFQTLLFVFVLR

ABCA6

1201

Q8N139
VAAIFIISYFLIFFL

NPFFR2

146

Q9Y5X5
FFILLISYVFILFTV

OR4F21

211

O95013
LFSFFFIIFIVFISR

LRRTM2

431

O43300
IFTVLLVLFFIFTYF

SLC2A1

436

P11166
LIAYAISFIFLFLNF

ELOVL4

251

Q9GZR5
ISFIFLFLNFYIRTY

ELOVL4

256

Q9GZR5
LVFFALFIIFKAYLI

LAPTM4A

166

Q15012
RYFFLFVSLIQFLII

PLVAP

26

Q9BX97
FFFLISIFFYDVKIL

OR2M2

326

Q96R28
ILFVFIFIFYSLTLF

OR2Y1

26

Q8NGV0
RKIQLLLFLFFSVFY

OR4F6

21

Q8NGB9
LELQIFYFLFFSIVY

OR4K3

21

Q96R72
FLFLLFLFFYIAIVL

OR4Q3

26

Q8NH05
FFVLLVIFISYLFIF

OR5B2

206

Q96R09
LVFVAGVFLFFYART

NEMP2

156

A6NFY4
YVFYFASFILLLREV

MARCHF6

431

O60337
FVFTLPFRIFYFTTR

LPAR6

66

P43657
LRLRTLFFVFFFLIY

OR10G3

21

Q8NGC4
LFFVFFFLIYILTQL

OR10G3

26

Q8NGC4
RELEFFLFVVFFAVY

OR4D6

21

Q8NGJ1
FFTISPIILYFLASF

ORMDL1

101

Q9P0S3
SYLRIFFIIFIVTFL

ITGB8

681

P26012
QVFLFLLFLAIYLFT

OR5T1

36

Q8NG75
RAFIFILTFLLYASF

SLC37A1

21

P57057
FFEILRLFFPVIYDV

CNOT7

181

Q9UIV1
FVLRRHVFFFVLQTY

GABRR3

261

A8MPY1
LYINFTLRRHIFFFL

GABRR1

271

P24046
TLRRHIFFFLLQTYF

GABRR1

276

P24046
YFISFLLIVAFFVLN

CACNA1G

1516

O43497
RVFFPTSFLLFNLVY

GABRG3

446

Q99928
FILFDVVVFLFVYFL

C4orf3

51

Q8WVX3
FPFFLIATVIQLFYR

HAS2

386

Q92819
FFFIALVFFLYRRRK

KIRREL1

511

Q96J84
STIFYFRIFIFIFHS

CXorf1

51

O96002
LFLVFVIVLFFIYHF

EMD

231

P50402
AIFLIFSIFIIIGFY

DNAJC30

211

Q96LL9
FFLLLYFLVLFVLAR

RNF103

6

O00237
YFLVLFVLARFFEAI

RNF103

11

O00237
IYRIIFDITFFFFVI

RYR2

4841

Q92736
IKYFLFVFNLFFFVL

CD37

11

P11049
LYINFTLRRHIFFFL

GABRR2

251

P28476
TLRRHIFFFLLQTYF

GABRR2

256

P28476
FELQVFLFLLFFAIY

OR5T3

51

Q8NGG3
FLFLLFFAIYLFTLI

OR5T3

56

Q8NGG3
ETFFLPVFFIFLLFY

OR2AT4

26

A6NND4
PRLEAVLFVFVLFFY

OR2G3

21

Q8NGZ4
VLFVFVLFFYLLTLV

OR2G3

26

Q8NGZ4
FFILLISYVFILFTV

OR4F3;

211

Q6IEY1
LKIVISFLLFYASFF

TAS2R13

231

Q9NYV9
FFLLYAIFSLSFFIS

TAS2R14

236

Q9NYV8
FDFIVRYFFAALTVL

PTCH2

1081

Q9Y6C5
TYYTILDIFRFALRF

FAF2

106

Q96CS3
FYILFFTVIIYVRLD

RPN1

446

P04843
LYFVIFIIFGSFFTL

SCN3A

1446

Q9NY46
ELQTIFFFLFLAIYL

OR5T2

61

Q8NGG2
IFFVLVIFLGSFYLI

SCN1A

401

P35498
LYFVIFIIFGSFFTL

SCN1A

1461

P35498
IRFLRFLANFFVFLT

TMC1

361

Q8TDI8
FKREFFPIVYLIIFF

CYSLTR2

36

Q9NS75
FYLIIFFFLIPLTVF

SLC34A2

531

O95436
YIFALLAVFNFLFLI

PIGA

426

P37287
LFAFANVLSYLRLFF

TRPC1

501

P48995
FDISLFRNPFFYIFT

SLC16A4

291

O15374
YTTIFKLVFLFTLFF

SOGA3

931

Q5TF21
SYFDIFLLAVFRFKV

STARD3NL

96

O95772
EFLFFIYLLVALFIQ

TMEM39A

76

Q9NV64
VAYTFFVYVLLFFLS

SLC12A9

306

Q9BXP2
FLYDIFFVFITPFLT

SPPL2B

356

Q8TCT7
LYFVIFIIFGSFFTL

SCN2A

1451

Q99250
LTLSFFFKFYLTVLQ

XDH

511

P47989
LGPIYFITFIFFVFF

PKD2L2

466

Q9NZM6
RAFFLVFFLVTAFFG

PIGN

786

O95427
IYFVVFIIFGSFFTL

SCN11A

1286

Q9UI33
FLVFFIAYLFVILLT

SLC5A12

81

Q1EHB4
FFFTLLFYLLSIAAV

SERINC2

206

Q96SA4
FLYRIVVGFILIFTF

XKR9

261

Q5GH70
FAFFIPLVIFYLSFI

WFS1

341

O76024