Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	PGA4 PGA5 PGA3	1.86e-04	37	60	3	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	PGA4 PGA5 PGA3	2.02e-04	38	60	3	GO:0070001
GeneOntologyCellularComponent	multivesicular body lumen	PGA4 PGA5 PGA3	7.41e-07	7	59	3	GO:0097486
GeneOntologyCellularComponent	late endosome lumen	PGA4 PGA5 PGA3	3.47e-06	11	59	3	GO:0031906
GeneOntologyCellularComponent	endosome lumen	PGA4 PGA5 PGA3	2.43e-04	43	59	3	GO:0031904
GeneOntologyCellularComponent	transferase complex	ERCC8 MEGF8 INSRR RBM15B POLR1B ACTL6B ACTL6A HCFC2 KLHL20 CBX8	3.31e-04	963	59	10	GO:1990234
GeneOntologyCellularComponent	GBAF complex	ACTL6B ACTL6A	6.97e-04	14	59	2	GO:0140288
GeneOntologyCellularComponent	brahma complex	ACTL6B ACTL6A	6.97e-04	14	59	2	GO:0035060
GeneOntologyCellularComponent	RSC-type complex	ACTL6B ACTL6A	8.03e-04	15	59	2	GO:0016586
Domain	Kelch_1	KLHL38 MEGF8 IPP HCFC2 KLHL20 KLHL26	1.05e-07	70	61	6	PF01344
Domain	Kelch_1	KLHL38 MEGF8 IPP HCFC2 KLHL20 KLHL26	1.05e-07	70	61	6	IPR006652
Domain	Aspartic_peptidase_N	PGA4 PGA5 PGA3	1.15e-06	7	61	3	IPR012848
Domain	A1_Propeptide	PGA4 PGA5 PGA3	1.15e-06	7	61	3	PF07966
Domain	Gal_Oxase/kelch_b-propeller	MEGF8 IPP HCFC2 KLHL20 KLHL26	1.37e-06	59	61	5	IPR011043
Domain	Aspartic_peptidase_A1	PGA4 PGA5 PGA3	3.91e-06	10	61	3	IPR001461
Domain	PEPTIDASE_A1	PGA4 PGA5 PGA3	3.91e-06	10	61	3	IPR033121
Domain	Asp	PGA4 PGA5 PGA3	3.91e-06	10	61	3	PF00026
Domain	PEPTIDASE_A1	PGA4 PGA5 PGA3	3.91e-06	10	61	3	PS51767
Domain	Gal_Oxidase_b-propeller	IPP HCFC2 KLHL20 KLHL26	4.44e-06	34	61	4	IPR015916
Domain	-	PGA4 PGA5 PGA3	7.14e-06	12	61	3	2.40.70.10
Domain	ASP_PROTEASE	PGA4 PGA5 PGA3	7.14e-06	12	61	3	PS00141
Domain	Aspartic_peptidase_AS	PGA4 PGA5 PGA3	9.26e-06	13	61	3	IPR001969
Domain	BTB-kelch_protein	KLHL38 IPP KLHL20 KLHL26	1.16e-05	43	61	4	IPR017096
Domain	-	KLHL38 MEGF8 IPP HCFC2	1.80e-05	48	61	4	2.120.10.80
Domain	Peptidase_aspartic_dom	PGA4 PGA5 PGA3	2.18e-05	17	61	3	IPR021109
Domain	Kelch-typ_b-propeller	KLHL38 MEGF8 IPP HCFC2	3.10e-05	55	61	4	IPR015915
Domain	Dsh_C	DVL2 DVL3	3.14e-05	3	61	2	PF12316
Domain	Dishevelled_C-dom	DVL2 DVL3	3.14e-05	3	61	2	IPR024580
Domain	Kelch	KLHL38 IPP KLHL20 KLHL26	3.83e-05	58	61	4	SM00612
Domain	BACK	KLHL38 IPP KLHL20 KLHL26	4.38e-05	60	61	4	SM00875
Domain	BACK	KLHL38 IPP KLHL20 KLHL26	4.68e-05	61	61	4	PF07707
Domain	BACK	KLHL38 IPP KLHL20 KLHL26	4.68e-05	61	61	4	IPR011705
Domain	Dsh/Dvl-rel	DVL2 DVL3	6.27e-05	4	61	2	IPR015506
Domain	Oxidoreductase_N	GFOD1 GFOD2	6.27e-05	4	61	2	IPR000683
Domain	GFO_IDH_MocA	GFOD1 GFOD2	6.27e-05	4	61	2	PF01408
Domain	Dishevelled_fam	DVL2 DVL3	6.27e-05	4	61	2	IPR008339
Domain	Dishevelled	DVL2 DVL3	6.27e-05	4	61	2	PF02377
Domain	Dishevelled_protein_dom	DVL2 DVL3	6.27e-05	4	61	2	IPR003351
Domain	BTB	KLHL38 IBTK IPP KLHL20 KLHL26	6.83e-05	131	61	5	PF00651
Domain	-	HCFC2 KLHL20 KLHL26	9.17e-05	27	61	3	2.130.10.80
Domain	PSI	MEGF8 PLXNA2 SEMA4G	1.54e-04	32	61	3	PF01437
Domain	Plexin_repeat	MEGF8 PLXNA2 SEMA4G	1.54e-04	32	61	3	IPR002165
Domain	BTB	KLHL38 IBTK IPP KLHL20 KLHL26	1.75e-04	160	61	5	PS50097
Domain	DIX	DVL2 DVL3	2.18e-04	7	61	2	PF00778
Domain	DIX	DVL2 DVL3	2.18e-04	7	61	2	IPR001158
Domain	DIX	DVL2 DVL3	2.18e-04	7	61	2	PS50841
Domain	DAX	DVL2 DVL3	2.18e-04	7	61	2	SM00021
Domain	BTB	KLHL38 IBTK IPP KLHL20 KLHL26	3.02e-04	180	61	5	SM00225
Domain	BTB/POZ_dom	KLHL38 IBTK IPP KLHL20 KLHL26	3.43e-04	185	61	5	IPR000210
Domain	SKP1/BTB/POZ	KLHL38 IBTK IPP KLHL20 KLHL26	3.78e-04	189	61	5	IPR011333
Domain	PSI	MEGF8 PLXNA2 SEMA4G	3.99e-04	44	61	3	IPR016201
Domain	PSI	MEGF8 PLXNA2 SEMA4G	4.55e-04	46	61	3	SM00423
Domain	Actin_CS	ACTL6B ACTL6A	1.22e-03	16	61	2	IPR004001
Domain	ACTINS_2	ACTL6B ACTL6A	1.38e-03	17	61	2	PS00432
Domain	fn3	PTPRC INSRR HCFC2 EPHA8	1.94e-03	162	61	4	PF00041
Domain	AA-permease/SLC12A_dom	SLC7A4 SLC12A8	2.32e-03	22	61	2	IPR004841
Domain	DEP	DVL2 DVL3	2.32e-03	22	61	2	PF00610
Domain	AA_permease	SLC7A4 SLC12A8	2.32e-03	22	61	2	PF00324
Domain	DEP	DVL2 DVL3	2.32e-03	22	61	2	PS50186
Domain	DEP	DVL2 DVL3	2.32e-03	22	61	2	SM00049
Domain	DEP_dom	DVL2 DVL3	2.54e-03	23	61	2	IPR000591
Domain	FN3	PTPRC INSRR HCFC2 EPHA8	3.13e-03	185	61	4	SM00060
Domain	FN3	PTPRC INSRR HCFC2 EPHA8	4.06e-03	199	61	4	PS50853
Domain	Sema	PLXNA2 SEMA4G	4.59e-03	31	61	2	SM00630
Domain	Semap_dom	PLXNA2 SEMA4G	4.59e-03	31	61	2	IPR001627
Domain	Sema	PLXNA2 SEMA4G	4.59e-03	31	61	2	PF01403
Domain	SEMA	PLXNA2 SEMA4G	4.59e-03	31	61	2	PS51004
Domain	Actin	ACTL6B ACTL6A	4.59e-03	31	61	2	IPR004000
Domain	Actin	ACTL6B ACTL6A	4.59e-03	31	61	2	PF00022
Domain	ACTIN	ACTL6B ACTL6A	4.59e-03	31	61	2	SM00268
Domain	FN3_dom	PTPRC INSRR HCFC2 EPHA8	4.83e-03	209	61	4	IPR003961
Domain	Ntn_hydrolases_N	PSMB9 GGT5	5.19e-03	33	61	2	IPR029055
Pathway	WP_GASTRIC_ACID_PRODUCTION	PGA4 PGA5 PGA3	6.00e-06	11	48	3	M39726
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_DVL_INTERACTING_PROTEINS	DVL2 DVL3	1.13e-04	5	48	2	M27447
Pathway	REACTOME_SURFACTANT_METABOLISM	PGA4 PGA5 PGA3	1.41e-04	30	48	3	M27566
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	ACTL6B ACTL6A CBX8	2.06e-04	34	48	3	MM15531
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	ACTL6B ACTL6A CBX8	2.65e-04	37	48	3	M27797
Pathway	REACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL	DVL2 DVL3	3.14e-04	8	48	2	M27100
Pathway	REACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL	DVL2 DVL3	4.03e-04	9	48	2	MM14792
Pubmed	Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2032552
Pubmed	Close linkage of human chromosomal pepsinogen A genes.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	3017318
Pubmed	Serum pepsinogen test for early detection of gastric cancer in a European country.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	21989121
Pubmed	Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	8053437
Pubmed	Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	9855083
Pubmed	Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	9797498
Pubmed	The glomerular sieving of pepsinogen A and C in man.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2478370
Pubmed	Analysis of the promoter of a human pepsinogen A gene.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	1812762
Pubmed	O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	7923573
Pubmed	Family and population studies on the human pepsinogen A multigene family.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2566575
Pubmed	Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	9061458
Pubmed	Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	12588289
Pubmed	Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	3815274
Pubmed	Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2229438
Pubmed	Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	25314140
Pubmed	Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	19890696
Pubmed	Pepsinogens: physiology, pharmacology pathophysiology and exercise.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	10675278
Pubmed	Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	23897256
Pubmed	An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	11566730
Pubmed	The effect of acute and chronic protein loading on urinary pepsinogen A excretion.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	1956484
Pubmed	The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	7926498
Pubmed	Transcription regulation of human and porcine pepsinogen A.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	8540382
Pubmed	Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	3780036
Pubmed	Crystal structure of human pepsinogen A.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	9561228
Pubmed	Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	8244094
Pubmed	The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	21455714
Pubmed	Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	21407214
Pubmed	Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	19800305
Pubmed	Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2901984
Pubmed	Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	22992016
Pubmed	The role of serum pepsinogen in the detection of gastric cancer.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	20981206
Pubmed	Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	3839486
Pubmed	Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	6774973
Pubmed	Gastric chief cell-specific transcription of the pepsinogen A gene.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	8504820
Pubmed	Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	21970995
Pubmed	Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	24170207
Pubmed	Primary structure of human pepsinogen gene.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	6300126
Pubmed	Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	22304859
Pubmed	Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	24004680
Pubmed	Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	8038355
Pubmed	Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	3467902
Pubmed	The pepsinogens of human gastric mucosa.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	4586732
Pubmed	Serum pepsinogens in gastric cancer screening.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	20428942
Pubmed	Relationships between the human pepsinogen DNA and protein polymorphisms.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	3014868
Pubmed	Human pepsinogen A isozymogen patterns in serum and gastric mucosa.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2227273
Pubmed	Genomic structure and evolution of the human pepsinogen A multigene family.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2892778
Pubmed	The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	24383519
Pubmed	The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	9525001
Pubmed	Gene structures of pepsinogens A and C.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	1455184
Pubmed	Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	7886402
Pubmed	Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2831884
Pubmed	Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	23034090
Pubmed	A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	24125879
Pubmed	Serum pepsinogen and gastric cancer screening.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	17379991
Pubmed	Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	8751234
Pubmed	Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	3554488
Pubmed	The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	2799289
Pubmed	CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	19872561
Pubmed	Human pepsinogen A (PGA): an informative gene complex located at 11q13.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	1968039
Pubmed	Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	21547904
Pubmed	Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.	PGA4 PGA5 PGA3	5.13e-09	3	61	3	23521833
Pubmed	Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.	PGA4 PGA5 PGA3	2.05e-08	4	61	3	23047493
Pubmed	Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.	PGA4 PGA5 PGA3	2.05e-08	4	61	3	8322031
Pubmed	Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.	PGA4 PGA5 PGA3	2.05e-08	4	61	3	17136346
Pubmed	Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.	PGA4 PGA5 PGA3	2.05e-08	4	61	3	12698190
Pubmed	Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.	PGA4 PGA5 PGA3	2.05e-08	4	61	3	11915945
Pubmed	Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.	PGA4 PGA5 PGA3	5.12e-08	5	61	3	22066020
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL38 IPP KLHL20 KLHL26	8.26e-07	41	61	4	23676014
Pubmed	Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.	PGA4 PGA5 PGA3 SLC27A4	8.26e-07	41	61	4	23676500
Pubmed	Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.	DVL2 DVL3 PLXNA2	1.12e-06	12	61	3	12421720
Pubmed	MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.	ACTL6B ACTL6A	3.03e-06	2	61	2	19561591
Pubmed	Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects.	DVL2 DVL3	3.03e-06	2	61	2	22892949
Pubmed	Crystal structure of human pepsin and its complex with pepstatin.	PGA4 PGA5	3.03e-06	2	61	2	7663352
Pubmed	Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.	ACTL6B ACTL6A	3.03e-06	2	61	2	10380635
Pubmed	RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes Wnt/β-Catenin Signaling in Endometrial Carcinoma.	MEX3A DVL3	3.03e-06	2	61	2	36614043
Pubmed	Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.	PGA4 PGA5	3.03e-06	2	61	2	2415509
Pubmed	Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.	PGA4 PGA5	3.03e-06	2	61	2	2714789
Pubmed	Planar polarization of node cells determines the rotational axis of node cilia.	DVL2 DVL3	3.03e-06	2	61	2	20098415
Pubmed	Activation of human pepsinogens.	PGA4 PGA5	3.03e-06	2	61	2	3197840
Pubmed	Immunomagnetic CD45 depletion does not improve cytokeratin 20 RT-PCR in colorectal cancer.	PTPRC KRT20	3.03e-06	2	61	2	17378731
Pubmed	Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma.	DVL2 DVL3	3.03e-06	2	61	2	23022960
Pubmed	Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.	PGA4 PGA5 PGA3	4.11e-06	18	61	3	36057966
Pubmed	Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.	DVL2 DVL3	9.07e-06	3	61	2	21092292
Pubmed	Dishevelled stability is positively regulated by PKCζ-mediated phosphorylation induced by Wnt agonists.	DVL2 DVL3	9.07e-06	3	61	2	28366812
Pubmed	BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens.	ACTL6B ACTL6A	9.07e-06	3	61	2	27226355
Pubmed	Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.	ACTL6B ACTL6A	9.07e-06	3	61	2	12437990
Pubmed	Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.	DVL2 DVL3	9.07e-06	3	61	2	18093802
Pubmed	Genomic organization of mouse Dishevelled genes.	DVL2 DVL3	9.07e-06	3	61	2	8973355
Pubmed	Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.	DVL2 DVL3	9.07e-06	3	61	2	18692936
Pubmed	DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.	DVL2 DVL3	9.07e-06	3	61	2	32900645
Pubmed	Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.	DVL2 DVL3	9.07e-06	3	61	2	27744318
Pubmed	Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.	DVL2 DVL3	9.07e-06	3	61	2	27086035
Pubmed	Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma.	DVL2 DVL3	9.07e-06	3	61	2	19137009
Pubmed	Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.	DVL2 DVL3	9.07e-06	3	61	2	23437169
Pubmed	A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.	PGA4 PGA5	9.07e-06	3	61	2	2515193
Pubmed	REST repression of neuronal genes requires components of the hSWI.SNF complex.	RCOR1 ACTL6B ACTL6A	1.63e-05	28	61	3	12192000
Pubmed	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.	DVL2 DVL3	1.81e-05	4	61	2	24643799
Pubmed	DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.	DVL2 DVL3	1.81e-05	4	61	2	25557784
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL2 DVL3	1.81e-05	4	61	2	8817329
Pubmed	Actin-related proteins.	ACTL6B ACTL6A	1.81e-05	4	61	2	10611965
GeneFamily	Kelch like\|BTB domain containing	KLHL38 IPP KLHL20 KLHL26	2.39e-06	42	41	4	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL38 IBTK IPP KLHL20 KLHL26	1.26e-05	134	41	5	861
GeneFamily	Dishevelled segment polarity proteins\|PDZ domain containing	DVL2 DVL3	3.00e-05	4	41	2	505
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GFOD1 NYAP1 KCNAB3 SEMA4G EPHA8	3.34e-06	167	61	5	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GFOD1 NYAP1 KCNAB3 SEMA4G EPHA8	3.34e-06	167	61	5	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ANKRD34A ACTL6B NYAP1 KCNAB3 RIT2	5.79e-06	187	61	5	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	wk_08-11-Hematologic-Myeloid-CX3CR1+_Mac\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PGA4 PTPRC CD163L1 PGA5 PGA3	6.75e-06	193	61	5	afc20433b5abc9b430751a2aa8d93b0fd136a888
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PGA4 PTPRC CD163L1 PGA5 PGA3	8.02e-06	200	61	5	a1ae299cf77580a6d1a728ee591888b6d70a19d6
Drug	Clemastine fumarate [14976-57-9]; Down 200; 8.6uM; HL60; HT_HG-U133A	ERCC8 FAM163A MEGF8 GFOD2 DVL2 ZNF747 KLHL26	9.59e-07	197	61	7	2412_DN
Disease	monocyte count	RCOR1 KIF3B PTPRC LTO1 PI4KA POLR1B NYAP1 CBX8 GGT5	1.17e-03	1320	59	9	EFO_0005091
Disease	smoking status measurement	ERCC8 FAM163A OR5A1 KCNAB3 PLXNA2 CBX8 DMAC1 RIT2	2.08e-03	1160	59	8	EFO_0006527
Disease	urinary bladder carcinoma	P3H2 PSD3	4.01e-03	47	59	2	MONDO_0004986
Disease	interferon gamma measurement	IBTK EPHA8	4.71e-03	51	59	2	EFO_0008165

Protein segments in the cluster

Peptide	Gene	Start	Entry
RVLSGLGLMGAGGYV	DMAC1	51	Q96GE9
MAAGGTGGLREEQRY	ELL2	1	O00472
RYTRGTGGRGTMLQG	A1CF	311	Q9NQ94
MSGGVYGGDEVGALV	ACTL6B	1	O94805
MSGGVYGGDEVGALV	ACTL6A	1	O96019
GVGGMVGSGLYVLTG	SLC7A4	46	O43246
IGMGLGNASTGYGKI	CD163L1	631	Q9NR16
RGDGGIYIGSIMKGG	DVL3	271	Q92997
SNERGDGGIYIGSIM	DVL2	286	O14641
EIQLQTAGGGGRGML	ANKRD34A	186	Q69YU3
MAAIYGGVEGGGTRS	NAGK	1	Q9UJ70
GGGGMRVGPQYQAVV	RCOR1	101	Q9UKL0
VGGSKGRDGTGMLYA	RBM15B	841	Q8NDT2
LGVTVLGGMVYAIGG	IPP	336	Q9Y573
SMTGILGYDTVQVGG	PGA5	141	P0DJD9
GTRILVFGGMVEYGR	HCFC2	81	Q9Y5Z7
REAVYTMGLNGGQLG	IBTK	301	Q9P2D0
GTMYGVIVRSEGEDG	PLXNA2	166	O75051
QGLCTRMVVGAYVGG	OR5A1	141	Q8NGJ0
TGGRYLSIGDGSVME	SLC10A3	61	P09131
AGRGAMYLLGGLTAG	MEGF8	1576	Q7Z7M0
MYLLGGLTAGGVTRD	MEGF8	1581	Q7Z7M0
GEVYGMIRFSGTTGQ	PI4KA	1151	P42356
YSMVVEGRDGGGLVA	PCDHGB5	311	Q9Y5G0
SVASGIMLVGDGYRG	P3H2	481	Q8IVL5
REGGQVYGTLGGMLT	PSMB9	126	P28065
MQRLGTTPSVYGGAG	KRT20	26	P35900
EYGGREMQDLGGGER	DSG1	636	Q02413
GRYMLSGGSDGVIVL	ERCC8	56	Q13216
SMTGILGYDTVQVGG	PGA3	141	P0DJD8
GMNYRRLGGGVGVIK	KLHL20	586	Q9Y2M5
HAMVGAGGRIYALGG	KLHL26	501	Q53HC5
SGGGLYRDMGAQGGR	CBX8	316	Q9HC52
LRGVGAGMRYLSDLG	EPHA8	741	P29322
GGGGLHTMGTYIVDL	GFOD2	171	Q3B7J2
MGLGGGVIFTIYNVT	GGT5	86	P36269
KGSYGNGGAMRVAGI	ADPRS	146	Q9NX46
GYEEGSSLGVMEGRQ	LTO1	26	Q8WV07
GQGSFGMVYEGLARG	INSRR	986	P14616
YIRTADMVPNGGGGE	FAM163A	106	Q96GL9
VYSMISSVLGGQTGG	SLC12A8	106	A0AV02
SMTGILGYDTVQVGG	PGA4	141	P0DJD7
YIEMVGDVFRGGGRS	NYAP1	216	Q6ZVC0
GALRESTGRGTGMKY	KCNAB3	66	O43448
LRGGAGVGSMTKIYG	RPS19	66	P39019
GSVAAGGRYDGLVGM	HARS2	356	P49590
DGVGQISGFYVGRLM	AIFM2	336	Q9BRQ8
DLMGGGGLHSVGTYI	GFOD1	166	Q9NXC2
GGSREYKVVMLGAGG	RIT2	16	Q99578
VLSGGYVLGGGALCM	UBE2Q2	291	Q8WVN8
MSYGSIARGGGLGSR	TSNARE1	1	Q96NA8
MGLSDGQGGYRVGVD	SEMA4G	601	Q9NTN9
VYGVEVPGTEGRAGM	SLC27A4	536	Q6P1M0
GQTGTGKTYTMEGIR	KIF3B	96	O15066
VSGIMERNGGFGELG	MEX3A	6	A1L020
MRETYGHLGALGVGG	ZNF747	66	Q9BV97
IGGRNVQGGIRFGEM	POLR1B	1026	Q9H9Y6
GVGRTGTYIGIDAML	PTPRC	856	P08575
GGIVMGYSSGVTNGL	PSD3	511	Q9NYI0
LGQGLGVACGMAYTG	TKTL1	96	P51854
SMRGGGGGNAREYKI	UFL1	431	O94874
FSIGGIGEGQELMGS	KLHL38	386	Q2WGJ6