Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Pyrin domain binding	NLRP7 NLRP2	3.63e-05	3	70	2	GO:0032090
GeneOntologyMolecularFunction	gated channel activity	KCNC2 TTYH2 SCNN1A CACNA1H KCNK13 CHRNA3 RYR3	1.67e-04	334	70	7	GO:0022836
GeneOntologyMolecularFunction	calcium ion binding	CAPN12 DCHS2 FAT4 ANKEF1 TTYH2 FLG2 PCDHGC3 CEMIP2 CDH17 RYR3	2.69e-04	749	70	10	GO:0005509
GeneOntologyMolecularFunction	aspartic-type endopeptidase inhibitor activity	NLRP7 NLRP2	4.29e-04	9	70	2	GO:0019828
GeneOntologyMolecularFunction	interleukin-1 binding	NLRP7 NLRP2	7.82e-04	12	70	2	GO:0019966
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNC2 TTYH2 SCNN1A CACNA1H KCNK13 CHRNA3 RYR3	1.11e-03	459	70	7	GO:0005216
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNC2 SCNN1A CACNA1H KCNK13 CHRNA3 RYR3	1.28e-03	343	70	6	GO:0005261
GeneOntologyMolecularFunction	caspase binding	NLRP7 NLRP2	1.41e-03	16	70	2	GO:0089720
GeneOntologyCellularComponent	cornified envelope	TGM1 KRT78 EVPL FLG2	8.94e-05	69	71	4	GO:0001533
GeneOntologyCellularComponent	monoatomic ion channel complex	KCNC2 TTYH2 SCNN1A CACNA1H KCNK13 CHRNA3 RYR3	2.94e-04	378	71	7	GO:0034702
GeneOntologyCellularComponent	transmembrane transporter complex	KCNC2 TTYH2 SCNN1A CACNA1H KCNK13 CHRNA3 UQCRHL RYR3	3.88e-04	523	71	8	GO:1902495
GeneOntologyCellularComponent	transporter complex	KCNC2 TTYH2 SCNN1A CACNA1H KCNK13 CHRNA3 UQCRHL RYR3	5.42e-04	550	71	8	GO:1990351
Domain	Vps16_C	VIPAS39 VPS16	1.42e-05	2	71	2	PF04840
Domain	Vps16_C	VIPAS39 VPS16	1.42e-05	2	71	2	IPR006925
Domain	-	RC3H2 ZC3H13 RC3H1	4.70e-04	40	71	3	4.10.1000.10
Domain	Cadherin_CS	DCHS2 FAT4 PCDHGC3 CDH17	7.90e-04	109	71	4	IPR020894
Domain	ZnF_C3H1	RC3H2 ZC3H13 RC3H1	8.05e-04	48	71	3	SM00356
Domain	zf-CCCH	RC3H2 ZC3H13 RC3H1	8.56e-04	49	71	3	PF00642
Domain	CADHERIN_1	DCHS2 FAT4 PCDHGC3 CDH17	9.04e-04	113	71	4	PS00232
Domain	Cadherin	DCHS2 FAT4 PCDHGC3 CDH17	9.04e-04	113	71	4	PF00028
Domain	CADHERIN_2	DCHS2 FAT4 PCDHGC3 CDH17	9.34e-04	114	71	4	PS50268
Domain	-	DCHS2 FAT4 PCDHGC3 CDH17	9.34e-04	114	71	4	2.60.40.60
Domain	CA	DCHS2 FAT4 PCDHGC3 CDH17	9.65e-04	115	71	4	SM00112
Domain	Cadherin-like	DCHS2 FAT4 PCDHGC3 CDH17	9.96e-04	116	71	4	IPR015919
Domain	Cadherin	DCHS2 FAT4 PCDHGC3 CDH17	1.06e-03	118	71	4	IPR002126
Domain	Znf_CCCH	RC3H2 ZC3H13 RC3H1	1.40e-03	58	71	3	IPR000571
Domain	ZF_C3H1	RC3H2 ZC3H13 RC3H1	1.40e-03	58	71	3	PS50103
Domain	DAPIN	NLRP7 NLRP2	3.13e-03	22	71	2	PS50824
Domain	PYRIN	NLRP7 NLRP2	3.13e-03	22	71	2	PF02758
Domain	DAPIN	NLRP7 NLRP2	3.13e-03	22	71	2	IPR004020
Domain	PYRIN	NLRP7 NLRP2	3.13e-03	22	71	2	SM01289
Domain	NACHT	NLRP7 NLRP2	3.42e-03	23	71	2	PS50837
Domain	NACHT_NTPase	NLRP7 NLRP2	3.42e-03	23	71	2	IPR007111
Domain	Znf-RING_LisH	RC3H2 RC3H1	7.39e-03	34	71	2	IPR027370
Domain	zf-RING_UBOX	RC3H2 RC3H1	7.39e-03	34	71	2	PF13445
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	RC3H2 MIA3 VIPAS39 VPS16 NME3 CSPP1 TRIP11	9.27e-07	251	72	7	29778605
Pubmed	NLRP2 controls age-associated maternal fertility.	NLRP7 NLRP2	4.23e-06	2	72	2	27881734
Pubmed	NLRP2 is highly expressed in a mouse model of ischemic stroke.	NLRP7 NLRP2	4.23e-06	2	72	2	27693696
Pubmed	Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect.	NLRP7 NLRP2	4.23e-06	2	72	2	33090377
Pubmed	A genetic association study of NLRP2 and NLRP7 genes in idiopathic recurrent miscarriage.	NLRP7 NLRP2	4.23e-06	2	72	2	23360675
Pubmed	Identification of new human cadherin genes using a combination of protein motif search and gene finding methods.	DCHS2 FAT4	4.23e-06	2	72	2	15003449
Pubmed	Nlrp2, a maternal effect gene required for early embryonic development in the mouse.	NLRP7 NLRP2	4.23e-06	2	72	2	22295082
Pubmed	E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR.	PDGFD HUWE1	4.23e-06	2	72	2	35472332
Pubmed	Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress.	NLRP7 NLRP2	4.23e-06	2	72	2	30454891
Pubmed	NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity.	NLRP7 NLRP2	4.23e-06	2	72	2	31162334
Pubmed	Structure of human Roquin-2 and its complex with constitutive-decay element RNA.	RC3H2 RC3H1	4.23e-06	2	72	2	26249698
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DCHS2 PHLDB1 CENPE YTHDC2 SORBS1 MEI1 CSPP1 RYR3	8.83e-06	497	72	8	36774506
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	MIA3 VIPAS39 ARHGEF1 SORBS1 ABLIM3	1.23e-05	143	72	5	32560809
Pubmed	Mosaic moles and non-familial biparental moles are not caused by mutations in NLRP7, NLRP2 or C6orf221.	NLRP7 NLRP2	1.27e-05	3	72	2	22909446
Pubmed	Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B.	NLRP7 NLRP2	1.27e-05	3	72	2	36976514
Pubmed	Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke.	NLRP7 NLRP2	1.27e-05	3	72	2	30172704
Pubmed	Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring.	NLRP7 NLRP2	1.27e-05	3	72	2	29574422
Pubmed	HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis.	NLRP7 NLRP2	1.27e-05	3	72	2	39052836
Pubmed	Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.	RC3H2 RC3H1	1.27e-05	3	72	2	30232334
Pubmed	Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.	RC3H2 RC3H1	1.27e-05	3	72	2	23583642
Pubmed	Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets.	RC3H2 RC3H1	1.27e-05	3	72	2	28188245
Pubmed	Uncoupling of Pyrin-only protein 2 (POP2)-mediated dual regulation of NF-κB and the inflammasome.	NLRP7 NLRP2	1.27e-05	3	72	2	21976665
Pubmed	Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function.	NLRP7 NLRP2	1.27e-05	3	72	2	37499769
Pubmed	No evidence for mutations in NLRP7, NLRP2 or KHDC3L in women with unexplained recurrent pregnancy loss or infertility.	NLRP7 NLRP2	1.27e-05	3	72	2	25376457
Pubmed	Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.	RC3H2 RC3H1	1.27e-05	3	72	2	25026077
Pubmed	NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse.	NLRP7 NLRP2	1.27e-05	3	72	2	28630100
Pubmed	Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma.	NLRP7 NLRP2	1.27e-05	3	72	2	37273114
Pubmed	Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.	RC3H2 RC3H1	2.53e-05	4	72	2	25697406
Pubmed	Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses.	NLRP7 NLRP2	2.53e-05	4	72	2	22750073
Pubmed	A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.	RC3H2 RC3H1	2.53e-05	4	72	2	31636267
Pubmed	The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response.	NLRP7 NLRP2	2.53e-05	4	72	2	23964092
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	TGM1 KRT78 HUWE1 FLG2	2.87e-05	84	72	4	29563501
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	CACNA1H SORBS1 XPC CHRNA3 RYR3	2.90e-05	171	72	5	20201926
Pubmed	Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization.	VIPAS39 VPS16	4.21e-05	5	72	2	20190753
Pubmed	Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.	NLRP7 NLRP2	4.21e-05	5	72	2	17046979
Pubmed	Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.	RC3H2 RC3H1	4.21e-05	5	72	2	27010430
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RC3H2 MIA3 ZNHIT6 ARHGEF1 YTHDC2 PCDHGC3 PBXIP1 CEMIP2	5.96e-05	650	72	8	38777146
Pubmed	Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.	TRIP11 EPAS1	6.31e-05	6	72	2	21512126
Pubmed	Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.	RC3H2 RC3H1	6.31e-05	6	72	2	34471108
Pubmed	Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.	NLRP7 NLRP2	6.31e-05	6	72	2	12387869
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 TARS3 GEMIN8 YLPM1 SORBS1 XPC HUWE1 TRIP11 PBXIP1 FRMD4B RYR3	6.42e-05	1285	72	11	35914814
Pubmed	Sequential expression of the MAD family of transcriptional repressors during differentiation and development.	MXD3 MXD4	8.82e-05	7	72	2	9519870
Pubmed	Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.	RC3H2 RC3H1	8.82e-05	7	72	2	34811541
Pubmed	PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.	NLRP7 NLRP2	8.82e-05	7	72	2	15817483
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT4	8.82e-05	7	72	2	16059920
Pubmed	Structural, expression, and evolutionary analysis of mouse CIAS1.	NLRP7 NLRP2	8.82e-05	7	72	2	15302403
Pubmed	SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.	VIPAS39 VPS16	1.17e-04	8	72	2	19109425
Pubmed	Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.	RC3H2 RC3H1	1.17e-04	8	72	2	25282160
Pubmed	Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors.	MXD3 MXD4	1.17e-04	8	72	2	10593926
Pubmed	Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.	VIPAS39 VPS16	1.17e-04	8	72	2	25783203
Pubmed	PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.	NLRP7 NLRP2	1.17e-04	8	72	2	12019269
Pubmed	Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.	VIPAS39 VPS16	1.17e-04	8	72	2	23901104
Pubmed	Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.	NLRP7 NLRP2	1.17e-04	8	72	2	28317850
Pubmed	Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.	RC3H2 RC3H1	1.17e-04	8	72	2	29246441
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	MXD3 MXD4	1.17e-04	8	72	2	8617250
Pubmed	Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.	RC3H2 RC3H1	1.17e-04	8	72	2	29352114
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MIA3 VIPAS39 CENPE PRDX4 YLPM1 HUWE1 FRMD4B CEMIP2	1.37e-04	733	72	8	34672954
Pubmed	SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance.	PRDX4 XPC	1.51e-04	9	72	2	20157331
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TGM1 TARS3 PHLDB1 KRT78 ARHGEF1 YTHDC2 SORBS1 ABLIM3 TRIP11 PBXIP1 ITPKA	1.66e-04	1431	72	11	37142655
Pubmed	Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.	MXD3 MXD4	1.88e-04	10	72	2	10229200
Pubmed	Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.	VIPAS39 VPS16	1.88e-04	10	72	2	26463206
Pubmed	Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc.	MXD3 MXD4	1.88e-04	10	72	2	9528857
Pubmed	EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.	TGM1 KRT78 FLG2	1.96e-04	54	72	3	35474131
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ZC3H13 YLPM1 YTHDC2 XPC HUWE1 CDH17 MRTFA PPP4R3A	1.98e-04	774	72	8	15302935
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNC2 SCNN1A CACNA1H KCNK13	2.04e-04	139	72	4	16985003
Pubmed	Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.	RC3H2 RC3H1	2.30e-04	11	72	2	23583643
Pubmed	Identification of new high affinity targets for Roquin based on structural conservation.	RC3H2 RC3H1	2.30e-04	11	72	2	30295819
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	YTHDC2 HUWE1 CSPP1 RTN2 ITPKA	2.57e-04	272	72	5	18187620
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	KRT78 EVPL FLG2	2.95e-04	62	72	3	26644517
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MIA3 YLPM1 YTHDC2 HUWE1 THAP12 PPP4R3A	3.06e-04	440	72	6	34244565
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	FAT4 PHLDB1 DNAH2 XPC CSPP1 TRIP11 CDH17	3.55e-04	638	72	7	31182584
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP7 NLRP2	3.78e-04	14	72	2	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP7 NLRP2	3.78e-04	14	72	2	12563287
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	MXD3 ANKEF1 ABTB1 DIP2C PBXIP1 MXD4 EPAS1 MRTFA	4.56e-04	877	72	8	20211142
Pubmed	New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.	RC3H2 RC3H1	5.63e-04	17	72	2	26489670
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	PHLDB1 ARHGEF1 ZC3H13 CACNA1H	6.26e-04	187	72	4	26460568
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	MXD3 MXD4	6.33e-04	18	72	2	8521822
Pubmed	Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.	DCHS2 FAT4	6.33e-04	18	72	2	33108146
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	MXD3 TGM1 ARHGEF1 ABTB1 ABLIM3 RTN2 MRTFA PPP4R3A	6.47e-04	925	72	8	28986522
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FAT4 CENPE ZC3H13 DNAH2 EVPL HUWE1 POTEA	8.27e-04	736	72	7	29676528
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MIA3 CENPE YLPM1 SORBS1 HUWE1 ABLIM3 TRIP11 BEGAIN	8.40e-04	963	72	8	28671696
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	TGM1 KRT78 FLG2	9.07e-04	91	72	3	34445801
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	MIA3 ARHGEF1 EVPL TRIP11 PBXIP1	9.16e-04	360	72	5	33111431
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	PHLDB1 KRT78 CENPE ZC3H13 YTHDC2	9.28e-04	361	72	5	26167880
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	MIA3 VIPAS39 CENPE GEMIN8 YTHDC2 HUWE1 FLG2 NME3 TRIP11 GNL1	9.95e-04	1496	72	10	32877691
Pubmed	Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.	MXD3 MXD4 EPAS1	1.12e-03	98	72	3	18557763
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	EVPL SORBS1 ABLIM3 NLRP2 TRIP11 CEMIP2	1.13e-03	565	72	6	25468996
Pubmed	Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.	DCHS2 FAT4	1.13e-03	24	72	2	26116661
Pubmed	Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.	DCHS2 FAT4	1.33e-03	26	72	2	21303848
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CWF19L2 CENPE SORBS1 HUWE1 TRIP11 PPP4R3A	1.38e-03	588	72	6	38580884
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZNHIT6 YLPM1 ABTB1 XPC HUWE1 EPAS1	1.42e-03	591	72	6	15231748
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	GNL1 MRTFA	1.43e-03	27	72	2	17525332
Pubmed	Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.	TGM1 KRT78 FLG2	1.45e-03	107	72	3	32989256
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	HUWE1 HTT	1.54e-03	28	72	2	25752541
Pubmed	Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.	SCNN1A EPAS1	1.54e-03	28	72	2	28847650
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	NLRP7 NLRP2	1.54e-03	28	72	2	25089626
Pubmed	The DNA sequence and analysis of human chromosome 14.	VIPAS39 YLPM1 TRIP11	1.61e-03	111	72	3	12508121
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	FAT4 VIPAS39 HUWE1 RTN2	1.72e-03	246	72	4	15345747
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CWF19L2 KRT78 ZC3H13 PRDX4 YLPM1 XPC FLG2 PBXIP1	1.76e-03	1082	72	8	38697112
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	NLRP7 NLRP2	1.77e-03	30	72	2	38786026
GeneFamily	Zinc fingers CCCH-type	RC3H2 ZC3H13 RC3H1	9.53e-05	35	46	3	73
GeneFamily	Basic helix-loop-helix proteins\|MAX dimerization proteins	MXD3 MXD4	1.32e-04	7	46	2	637
GeneFamily	Cadherin related	DCHS2 FAT4	8.41e-04	17	46	2	24
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP7 NLRP2	1.83e-03	25	46	2	994
GeneFamily	NLR family	NLRP7 NLRP2	1.83e-03	25	46	2	666
GeneFamily	EF-hand domain containing	CAPN12 ANKEF1 FLG2 RYR3	2.29e-03	219	46	4	863
GeneFamily	Basic helix-loop-helix proteins	MXD3 MXD4 EPAS1	2.75e-03	110	46	3	420
GeneFamily	Ankyrin repeat domain containing	ANKEF1 ABTB1 POTEA	2.36e-02	242	46	3	403
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PHLDB1 LAMA2 SORBS1 ABLIM3 EPAS1 CEMIP2	8.76e-07	200	72	6	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PHLDB1 LAMA2 SORBS1 ABLIM3 EPAS1 CEMIP2	8.76e-07	200	72	6	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PHLDB1 LAMA2 SORBS1 ABLIM3 EPAS1 CEMIP2	8.76e-07	200	72	6	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PHLDB1 LAMA2 SORBS1 ABLIM3 EPAS1 CEMIP2	8.76e-07	200	72	6	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PHLDB1 LAMA2 SORBS1 ABLIM3 EPAS1 CEMIP2	8.76e-07	200	72	6	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PHLDB1 LAMA2 SORBS1 ABLIM3 EPAS1 CEMIP2	8.76e-07	200	72	6	7136936d05ab344a560cf159684c881063b5430d
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CACNA1H MRTFA RYR3 MAST3 ITPKA	7.82e-06	168	72	5	6db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGM1 EVPL MAP3K12 PCDHGC3 BEGAIN	9.79e-06	176	72	5	3766e0533b103ec92ac75eba3df02e287efc53fa
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGM1 EVPL MAP3K12 PCDHGC3 BEGAIN	9.79e-06	176	72	5	aa1bada2175d8370fc71939a607407155259d195
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 ALKBH7 MAP3K12 EPAS1 CEMIP2	1.01e-05	177	72	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DCHS2 PHLDB1 SORBS1 CSPP1 EPAS1	1.15e-05	182	72	5	a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PHLDB1 DIP2C SORBS1 MRTFA RYR3	1.25e-05	185	72	5	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGM1 KRT78 SCNN1A EVPL RTN2	1.28e-05	186	72	5	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 PHLDB1 SORBS1 CSPP1 EPAS1	1.42e-05	190	72	5	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DCHS2 PHLDB1 SORBS1 CSPP1 EPAS1	1.42e-05	190	72	5	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 PHLDB1 SORBS1 CSPP1 EPAS1	1.45e-05	191	72	5	f229abf69a1217194f74b0502486907e07dba989
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DCHS2 MIA3 CACNA1H RYR3	8.74e-05	144	72	4	08005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCell	COVID-19-Mast_cells-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	DIP2C CACNA1H RYR3 BEGAIN	1.19e-04	156	72	4	bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCell	COVID-19-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	DIP2C CACNA1H RYR3 BEGAIN	1.19e-04	156	72	4	159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MXD3 NLRP7 PCDHGC3 UQCRHL	1.25e-04	158	72	4	17a13c5719eb363f2eb8f1d4e171429c6a1ce1e9
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MXD3 NLRP7 PCDHGC3 UQCRHL	1.25e-04	158	72	4	1397078f909338fa5fa3b01748db891e5e3fc9e7
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	MXD3 NLRP7 PCDHGC3 UQCRHL	1.25e-04	158	72	4	e5451cfe67e882eb0c1eca287740f8ab75370abc
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MXD3 NLRP7 PCDHGC3 UQCRHL	1.28e-04	159	72	4	6ecc3cb2daa5887b59836842be414a00cdcdaeec
ToppCell	Bac-SEP-Lymphocyte-T_NK-MAIT\|Bac-SEP / Disease, Lineage and Cell Type	ANKEF1 LAMA2 PBXIP1 ITPKA	1.28e-04	159	72	4	e043c65f3febdfa7f75a67702e92fcdebe144a00
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MXD3 NLRP7 PCDHGC3 UQCRHL	1.28e-04	159	72	4	1827493fb464bbddb2ee23f99472cfbcaf57405b
ToppCell	Mild_COVID-19-B_cell-Plasmablast\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	MXD3 NLRP7 PCDHGC3 UQCRHL	1.38e-04	162	72	4	b67f6fb3d7f6093c8ef02398ff8fea4d0fb41a3b
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAPN12 MXD3 CENPE SORBS1	1.41e-04	163	72	4	7864e966c228282b4b63c43164dba3faba21026d
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KRT78 MUC15 ANKEF1 DNAH2	1.44e-04	164	72	4	e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DIP2C CACNA1H RYR3 BEGAIN	1.48e-04	165	72	4	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DIP2C CACNA1H RYR3 BEGAIN	1.48e-04	165	72	4	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DIP2C CACNA1H RYR3 BEGAIN	1.48e-04	165	72	4	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TARS3 NLRP7 PRDX4 MEI1	1.51e-04	166	72	4	a1009d25c5a500f470e8edb04097ac47d4d72f3c
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TARS3 NLRP7 PRDX4 MEI1	1.51e-04	166	72	4	5a6e3364d223829f66e8da7f3560d95fd8bb9b11
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TARS3 NLRP7 PRDX4 MEI1	1.51e-04	166	72	4	e25bcbb5b3ba453a6e2572637f2521a32223a3ad
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MXD3 CENPE SCNN1A EVPL	1.55e-04	167	72	4	a90f905ef38437752e2b0b71bd0322a184de1861
ToppCell	390C-Lymphocytic-ILC-ILC-2\|390C / Donor, Lineage, Cell class and subclass (all cells)	ANKEF1 NLRP2 CSPP1 GNL1	1.58e-04	168	72	4	2781dd6b369427a94c5059b44b4c8f023f5f2988
ToppCell	Dividing_Macrophages-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	MXD3 CENPE KCNK13 ITPKA	1.62e-04	169	72	4	eb0c993ef2eea73bc4881182520922ce9ae9368f
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	DIP2C CACNA1H RYR3 BEGAIN	1.62e-04	169	72	4	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	DIP2C CACNA1H RYR3 BEGAIN	1.66e-04	170	72	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCNN1A XPC PBXIP1 CEMIP2	1.69e-04	171	72	4	355a27ea88410a84210f7e4298c7c4f90cf2f8a9
ToppCell	390C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ANKEF1 NLRP2 CSPP1 EPAS1	1.73e-04	172	72	4	84d16cd7f618c94888920680bdc9e7130d73fd75
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PHLDB1 LAMA2 ITPKA	1.89e-04	176	72	4	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	facs-Lung-EPCAM-18m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNC2 SORBS1 EPAS1 CEMIP2	1.93e-04	177	72	4	2433924dcb085ebbe2545d476ebd7ee68e6092fb
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDGFD SORBS1 ABLIM3 EPAS1	1.98e-04	178	72	4	a3f95f0002f408b5b6c57e28b297b5b2737e919c
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 CACNA1H CEMIP2 RYR3	2.02e-04	179	72	4	7954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell	facs-GAT-Fat-18m-Endothelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 SORBS1 ABLIM3 EPAS1	2.02e-04	179	72	4	d56fa2a0b119d51a8d41b00fbbd7dfddefeb279c
ToppCell	facs-GAT-Fat-18m-Endothelial-endothelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 SORBS1 ABLIM3 EPAS1	2.02e-04	179	72	4	e0542694fa79d67f67be6f85b4fa6d18f7523253
ToppCell	facs-GAT-Fat-18m-Endothelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 SORBS1 ABLIM3 EPAS1	2.02e-04	179	72	4	83343b68977969c7978acd930a66fc7c44df6a15
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 ALKBH7 MAP3K12 CEMIP2	2.11e-04	181	72	4	4df7972f88117108698efd06b124b232f8588981
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PDGFD SORBS1 EPAS1 CEMIP2	2.11e-04	181	72	4	9cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 ALKBH7 MAP3K12 CEMIP2	2.11e-04	181	72	4	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 CEMIP2 MAST3 ITPKA	2.15e-04	182	72	4	cc6f9d606a4f8717dc44928ceec2a257636043fd
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MXD3 KRT78 CENPE TTYH2	2.15e-04	182	72	4	21dcab170ffeef89faa9fee5008568cb6e15c694
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MXD3 CENPE PROCA1 LAMA2	2.15e-04	182	72	4	904804813849b7f7f716ba1554d33b07bc0a701e
ToppCell	COPD-Myeloid-Mast\|World / Disease state, Lineage and Cell class	DIP2C CACNA1H SORBS1 RYR3	2.15e-04	182	72	4	68a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MXD3 CENPE PROCA1 LAMA2	2.15e-04	182	72	4	5d8b7fe18286e27f0f50c5d2d9be56850e2cb8f4
ToppCell	COVID-19-Epithelial_cells-ECM-high_epithelial\|COVID-19 / group, cell type (main and fine annotations)	KCNC2 SCNN1A LAMA2 SORBS1	2.20e-04	183	72	4	dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	DIP2C CACNA1H SORBS1 RYR3	2.34e-04	186	72	4	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	TGM1 KRT78 EVPL FLG2	2.38e-04	187	72	4	2ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCell	COPD-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	PHLDB1 SORBS1 CSPP1 EPAS1	2.43e-04	188	72	4	1aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D122\|Adult / Lineage, Cell type, age group and donor	PHLDB1 SORBS1 EPAS1 CEMIP2	2.43e-04	188	72	4	02a62888e9db29d20133eeca1686d302545a39c9
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PHLDB1 LAMA2 CACNA1H FRMD4B	2.43e-04	188	72	4	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHLDB1 TTYH2 KCNK13 TMEM151A	2.48e-04	189	72	4	bab0fe55643d3ee750355a32b1ff6634fa5cf88d
ToppCell	Hippocampus-Neuronal-Excitatory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RC3H2 RYR3 MAST3 ITPKA	2.48e-04	189	72	4	4b90d181eb0a42814eeb23bc82e52fd3a12392a7
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	LAMA2 SORBS1 EPAS1 CEMIP2	2.53e-04	190	72	4	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS1 ABLIM3 EPAS1 CEMIP2	2.53e-04	190	72	4	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	COPD-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	DIP2C CACNA1H SORBS1 RYR3	2.53e-04	190	72	4	379dbac19110b76079a7a53209569e060a852acb
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	TGM1 KRT78 EVPL FLG2	2.53e-04	190	72	4	3188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCell	TCGA-Skin-Primary_Tumor\|TCGA-Skin / Sample_Type by Project: Shred V9	TGM1 KRT78 EVPL FLG2	2.53e-04	190	72	4	e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	TGM1 KRT78 EVPL FLG2	2.53e-04	190	72	4	01fb45add4661bc86cd0a34fac35177907152dbb
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS1 ABLIM3 EPAS1 CEMIP2	2.53e-04	190	72	4	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS1 ABLIM3 EPAS1 CEMIP2	2.53e-04	190	72	4	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	Severe-Treg\|World / Disease group and Cell class	TGM1 PRDX4 PBXIP1 FRMD4B	2.58e-04	191	72	4	0a80b8c317e8da4d4722cfd13cdabc32b58021eb
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Fos_(Deep_layer_pyramidal_cells--layer_5_(IEG))\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DCHS2 ANKEF1 DNAH2	2.64e-04	77	72	3	4879a1a72b950dadb78bc0312be75f1a32b935d5
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PDGFD PCDHGC3 CEMIP2	2.69e-04	193	72	4	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM151A RYR3 MAST3 ITPKA	2.69e-04	193	72	4	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	CD8+_Memory_T_cell-CV-0\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ABTB1 PBXIP1 MXD4 MAST3	2.69e-04	193	72	4	995781d87a919c0380750878bafe584342bb83ad
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PDGFD PCDHGC3 CEMIP2	2.69e-04	193	72	4	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)\|Adult / Lineage, Cell type, age group and donor	PHLDB1 SORBS1 EPAS1 CEMIP2	2.69e-04	193	72	4	39c6c96a2a100b1b290a779d36cc6bc17245720b
ToppCell	facs-MAT-Fat-3m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS1 ABLIM3 EPAS1 CEMIP2	2.69e-04	193	72	4	b32533afeff1905e188becaa09079e9699722e4b
ToppCell	CF-Epithelial\|CF / Disease state, Lineage and Cell class	KRT78 SCNN1A EVPL ABLIM3	2.69e-04	193	72	4	518901c2e36a79c6189cd0d9e6d36dbd4f56a79c
ToppCell	facs-MAT-Fat-3m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS1 ABLIM3 EPAS1 CEMIP2	2.69e-04	193	72	4	2ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PDGFD PCDHGC3 CEMIP2	2.69e-04	193	72	4	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	facs-MAT-Fat-3m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS1 ABLIM3 EPAS1 CEMIP2	2.69e-04	193	72	4	e164f6403a8b541ced08a6feec915d2e855036ea
ToppCell	CF-Epithelial-Epithelial_cell\|CF / Disease state, Lineage and Cell class	KRT78 SCNN1A EVPL ABLIM3	2.69e-04	193	72	4	4e3dda27c71b7fdac90d081f0d8e9ca3a8ea7820
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	PHLDB1 PDGFD LAMA2 MRTFA	2.74e-04	194	72	4	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS1 TRIP11 EPAS1 CEMIP2	2.74e-04	194	72	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	CTRL-Epithelial-Epithelial_cell\|CTRL / Disease state, Lineage and Cell class	KRT78 SCNN1A EVPL ABLIM3	2.74e-04	194	72	4	2bc4deaf2a01a39809fc323962fce4286835209c
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 SORBS1 EPAS1 CEMIP2	2.74e-04	194	72	4	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	PHLDB1 PDGFD LAMA2 MRTFA	2.74e-04	194	72	4	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	CTRL-Epithelial\|CTRL / Disease state, Lineage and Cell class	KRT78 SCNN1A EVPL ABLIM3	2.74e-04	194	72	4	49dcb31427f370692308f939e23992925708abb7
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 PHLDB1 SORBS1 EPAS1	2.74e-04	194	72	4	40842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell	CV-Moderate-0\|CV / Virus stimulation, Condition and Cluster	ABTB1 PBXIP1 MXD4 MAST3	2.74e-04	194	72	4	9ff69139dae007fcc349daefcb5021defb0e0d2a
ToppCell	distal-Hematologic-Plasma-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NLRP7 PRDX4 MEI1 PBXIP1	2.80e-04	195	72	4	4280a5bc5ed9bb12e278b182e0be6cb88fa83d83
ToppCell	facs-Heart-RA-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS1 ABLIM3 EPAS1 CEMIP2	2.80e-04	195	72	4	f4fdcc0b851392086e9618e76ee6a0b540d5fb3c
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFD SORBS1 EPAS1 CEMIP2	2.80e-04	195	72	4	e5f14f6015ea5e6fa065f906ad22157e3de15c68
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	PHLDB1 PDGFD LAMA2 MRTFA	2.80e-04	195	72	4	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFD SORBS1 EPAS1 CEMIP2	2.80e-04	195	72	4	5b84fd5be31386eb1d6048bbf28626032361842e
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	PHLDB1 PDGFD LAMA2 MRTFA	2.80e-04	195	72	4	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	facs-Heart-RA-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFD SORBS1 ABLIM3 CEMIP2	2.80e-04	195	72	4	30c75761079fa1e1a3b84d23c88a222f459d5ce5
Drug	Methylergometrine maleate [113-42-8]; Up 200; 8.8uM; MCF7; HT_HG-U133A	MXD3 LAMA2 CSPP1 TRIP11 MAP3K12 PBXIP1 CHRNA3	2.45e-06	194	71	7	5303_UP
Drug	Nystatine [1400-61-9]; Up 200; 4.4uM; HL60; HT_HG-U133A	PHLDB1 ZC3H13 TRIP11 PBXIP1 MXD4 ITPKA BEGAIN	2.54e-06	195	71	7	2500_UP
Drug	Biotin [58-85-5]; Down 200; 16.4uM; HL60; HT_HG-U133A	RC3H2 PDGFD RTN2 PBXIP1 MXD4 EPAS1 MRTFA	2.81e-06	198	71	7	2428_DN
Drug	Alfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A	MXD3 PHLDB1 ABLIM3 CSPP1 FRMD4B MRTFA MAST3	2.81e-06	198	71	7	5242_DN
Drug	8-((4-chlorophenyl)thio)cyclic-3',5'-AMP	KCNC2 SCNN1A FRMD4B	1.58e-05	16	71	3	ctd:C015929
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA	MXD3 YLPM1 ABLIM3 RTN2 MXD4 PPP4R3A	2.17e-05	181	71	6	1077_UP
Drug	Helveticoside [630-64-8]; Down 200; 7.4uM; PC3; HT_HG-U133A	MXD3 PHLDB1 ARHGEF1 ANKEF1 MAP3K12 PBXIP1	2.45e-05	185	71	6	4327_DN
Drug	Dicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A	SCNN1A YTHDC2 HUWE1 PBXIP1 FRMD4B PPP4R3A	2.68e-05	188	71	6	4405_UP
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	MXD3 MIA3 GEMIN8 HUWE1 PBXIP1 MXD4	2.77e-05	189	71	6	5587_UP
Drug	LY294002; Up 200; 10uM; MCF7; HG-U133A	MXD3 RTN2 KIAA1614 CHRNA3 MXD4 MAST3	3.11e-05	193	71	6	318_UP
Drug	rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	MXD3 CACNA1H HUWE1 RTN2 PBXIP1 MXD4	3.11e-05	193	71	6	921_UP
Drug	Lynestrenol [52-76-6]; Down 200; 14uM; PC3; HT_HG-U133A	MXD3 RC3H2 CSPP1 PBXIP1 MRTFA PPP4R3A	3.20e-05	194	71	6	6756_DN
Drug	Serotonin hydrochloride [153-98-0]; Down 200; 18.8uM; MCF7; HT_HG-U133A	PHLDB1 MIA3 ZC3H13 EVPL TRIP11 RTN2	3.20e-05	194	71	6	5268_DN
Drug	Cyclopenthiazide [742-20-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A	ARHGEF1 CACNA1H SORBS1 TRIP11 RTN2 MXD4	3.30e-05	195	71	6	4813_UP
Drug	Amethopterin (R,S) [59-05-2]; Up 200; 8.8uM; MCF7; HT_HG-U133A	MIA3 GEMIN8 DNAH2 SORBS1 MXD4 MAST3	3.39e-05	196	71	6	5000_UP
Drug	Harpagoside [19210-12-9]; Down 200; 8uM; HL60; HT_HG-U133A	MXD3 PDGFD TMEM134 TRIP11 PBXIP1 MXD4	3.39e-05	196	71	6	2935_DN
Drug	Perhexiline maleate [6724-53-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	FAT4 YTHDC2 CSPP1 MAP3K12 PBXIP1 MAST3	3.39e-05	196	71	6	5081_DN
Drug	Probucol [23288-49-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	MXD3 MIA3 EVPL YTHDC2 RTN2 MXD4	3.39e-05	196	71	6	5261_DN
Drug	Levonordefrin [829-74-3]; Up 200; 21.8uM; MCF7; HT_HG-U133A	PHLDB1 YLPM1 SORBS1 RTN2 MRTFA BEGAIN	3.39e-05	196	71	6	7208_UP
Drug	Epiandrosterone [481-29-8]; Up 200; 13.8uM; HL60; HT_HG-U133A	YLPM1 SCNN1A DIP2C HUWE1 PBXIP1 CHRNA3	3.49e-05	197	71	6	2444_UP
Drug	Ketanserin tartrate hydrate [83846-83-7]; Up 200; 7uM; MCF7; HT_HG-U133A	MIA3 EVPL VPS16 CHRNA3 MXD4 EPAS1	3.49e-05	197	71	6	3209_UP
Drug	Doxepin hydrochloride [1229-29-4]; Up 200; 12.6uM; MCF7; HT_HG-U133A	ZC3H13 ANKEF1 YTHDC2 CACNA1H RTN2 MXD4	3.49e-05	197	71	6	7415_UP
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; MCF7; HT_HG-U133A	FAT4 ARHGEF1 MAP3K12 CHRNA3 MXD4 BEGAIN	3.49e-05	197	71	6	3622_DN
Drug	Levopropoxyphene napsylate [5714-90-9]; Down 200; 7.4uM; PC3; HT_HG-U133A	YLPM1 YTHDC2 CSPP1 MAP3K12 PBXIP1 MAST3	3.59e-05	198	71	6	5083_DN
Drug	estradiol, USP; Down 200; 0.01uM; HL60; HG-U133A	PHLDB1 ZC3H13 SCNN1A PBXIP1 MAST3 BEGAIN	3.59e-05	198	71	6	387_DN
Drug	Theophylline monohydrate [5967-84-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A	MXD3 PHLDB1 GEMIN8 CACNA1H CSPP1 MXD4	3.59e-05	198	71	6	3326_DN
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; HL60; HT_HG-U133A	PHLDB1 YLPM1 SCNN1A YTHDC2 TRIP11 BEGAIN	3.59e-05	198	71	6	2492_UP
Drug	Sotalol hydrochloride [959-24-0]; Up 200; 13uM; PC3; HT_HG-U133A	DCHS2 ZC3H13 LAMA2 VPS16 FRMD4B EPAS1	3.59e-05	198	71	6	4079_UP
Drug	THIP Hydrochloride; Down 200; 22.6uM; PC3; HT_HG-U133A	PHLDB1 ANKEF1 XPC PBXIP1 CEMIP2 HTT	3.59e-05	198	71	6	7266_DN
Drug	monastrol; Down 200; 20uM; MCF7; HG-U133A	EVPL SORBS1 NLRP2 TRIP11 MXD4 MAST3	3.59e-05	198	71	6	605_DN
Drug	Pergolide mesylate [66104-23-2]; Down 200; 9.8uM; PC3; HT_HG-U133A	MXD3 RC3H2 XPC NME3 MAP3K12 RTN2	3.69e-05	199	71	6	7271_DN
Drug	Rilmenidine hemifumarate [54187-04-1]; Up 200; 8.4uM; HL60; HT_HG-U133A	ZC3H13 YTHDC2 MAP3K12 PBXIP1 MXD4 ITPKA	3.69e-05	199	71	6	3133_UP
Drug	1 Ni	TGM1 KCNK13 XPC THAP12	9.89e-05	77	71	4	CID000447618
Drug	tetracaine	SCNN1A NME3 CHRNA3 RYR3	1.66e-04	88	71	4	CID000005411
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA	MXD3 XPC RTN2 PBXIP1 MXD4	2.08e-04	173	71	5	1016_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	SORBS1 RTN2 PBXIP1 EPAS1 MAST3	2.19e-04	175	71	5	2268_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	SORBS1 RTN2 PBXIP1 EPAS1 MAST3	2.43e-04	179	71	5	2794_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	SORBS1 RTN2 PBXIP1 FRMD4B MAST3	2.49e-04	180	71	5	6064_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	MAP3K12 RTN2 PBXIP1 EPAS1 MAST3	2.49e-04	180	71	5	7407_UP
Drug	Trifluoperazine dihydrochloride [440-17-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	MXD3 MAP3K12 RTN2 PBXIP1 MAST3	2.49e-04	180	71	5	7420_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	SORBS1 RTN2 PBXIP1 EPAS1 MAST3	2.56e-04	181	71	5	5987_UP
Drug	Terbutaline hemisulfate [23031-32-5]; Up 200; 7.2uM; PC3; HT_HG-U133A	HUWE1 FRMD4B EPAS1 PPP4R3A ITPKA	2.69e-04	183	71	5	5764_UP
Drug	Etoposide [33419-42-0]; Up 200; 6.8uM; MCF7; HT_HG-U133A	XPC MAP3K12 PBXIP1 CHRNA3 MXD4	2.69e-04	183	71	5	5027_UP
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA	MXD3 MIA3 RTN2 PBXIP1 MXD4	2.76e-04	184	71	5	1007_UP
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	MIA3 XPC RTN2 PBXIP1 MXD4	2.90e-04	186	71	5	1664_UP
Drug	rosiglitazone; Down 200; 10uM; PC3; HT_HG-U133A	MXD3 TRIP11 RTN2 PBXIP1 PPP4R3A	2.97e-04	187	71	5	4457_DN
Drug	Mometasone furoate [83919-23-7]; Down 200; 7.6uM; PC3; HT_HG-U133A	PHLDB1 EVPL YTHDC2 CSPP1 MAP3K12	3.05e-04	188	71	5	5116_DN
Drug	17-DMAG; Down 200; 0.1uM; PC3; HT_HG-U133A	DIP2C TRIP11 MAP3K12 CEMIP2 MRTFA	3.05e-04	188	71	5	1213_DN
Drug	wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A_EA	MXD3 PHLDB1 RTN2 PBXIP1 MXD4	3.05e-04	188	71	5	1023_UP
Drug	C768-0445; Up 200; 10uM; MCF7; HT_HG-U133A_EA	MXD3 MAP3K12 RTN2 PBXIP1 MXD4	3.12e-04	189	71	5	973_UP
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	MXD3 PHLDB1 SCNN1A PBXIP1 MXD4	3.20e-04	190	71	5	5602_UP
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	MXD3 YLPM1 PBXIP1 MXD4 MRTFA	3.20e-04	190	71	5	6956_UP
Drug	Isotretinoin [4759-48-2]; Down 200; 13.4uM; MCF7; HT_HG-U133A	MXD3 PHLDB1 ARHGEF1 EVPL XPC	3.28e-04	191	71	5	7438_DN
Drug	Resveratrol [501-36-0]; Down 200; 17.6uM; MCF7; HT_HG-U133A	CENPE YLPM1 CSPP1 MRTFA PPP4R3A	3.36e-04	192	71	5	5509_DN
Drug	Chlorhexidine [55-56-1]; Up 200; 8uM; MCF7; HT_HG-U133A	ARHGEF1 PDGFD RTN2 FRMD4B MRTFA	3.36e-04	192	71	5	1525_UP
Drug	Moxalactam disodium salt [64953-12-4]; Down 200; 7uM; HL60; HT_HG-U133A	RC3H2 CSPP1 TRIP11 PBXIP1 MXD4	3.44e-04	193	71	5	3028_DN
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	MXD3 CSPP1 MAP3K12 RTN2 PBXIP1	3.52e-04	194	71	5	7001_UP
Drug	Cyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A	PHLDB1 EVPL CACNA1H MXD4 MAST3	3.52e-04	194	71	5	4411_DN
Drug	Acemetacin [53164-05-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	YTHDC2 CACNA1H TRIP11 MAP3K12 MRTFA	3.52e-04	194	71	5	7442_UP
Drug	Fluphenazine dihydrochloride [146-56-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	MXD3 KCNK13 RTN2 MXD4 MRTFA	3.52e-04	194	71	5	5880_UP
Drug	Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	PHLDB1 TMEM134 EVPL RTN2 MXD4	3.52e-04	194	71	5	4804_DN
Drug	Fludrocortisone acetate [514-36-3]; Up 200; 9.4uM; PC3; HT_HG-U133A	DCHS2 ZC3H13 SCNN1A ABLIM3 MAP3K12	3.52e-04	194	71	5	3785_UP
Drug	Chloramphenicol [56-75-7]; Down 200; 12.4uM; PC3; HT_HG-U133A	EVPL MAP3K12 EPAS1 PPP4R3A HTT	3.52e-04	194	71	5	5047_DN
Drug	radicicol; Up 200; 0.1uM; PC3; HG-U133A	ZC3H13 PBXIP1 CHRNA3 MXD4 HTT	3.61e-04	195	71	5	449_UP
Drug	Glipizide [29094-61-9]; Up 200; 9uM; MCF7; HT_HG-U133A	ARHGEF1 EVPL HUWE1 MAP3K12 MRTFA	3.61e-04	195	71	5	4991_UP
Drug	Nefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A	PHLDB1 CACNA1H TRIP11 PBXIP1 MRTFA	3.61e-04	195	71	5	2317_DN
Drug	Bicuculline (+) [485-49-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	ZC3H13 CACNA1H TRIP11 CHRNA3 MRTFA	3.61e-04	195	71	5	2796_UP
Drug	Benzathine benzylpenicillin [5928-84-7]; Up 200; 4.2uM; MCF7; HT_HG-U133A	PDGFD CACNA1H TRIP11 MXD4 MAST3	3.61e-04	195	71	5	7359_UP
Drug	Finasteride [98319-26-7]; Down 200; 10.8uM; PC3; HT_HG-U133A	EVPL RTN2 MXD4 EPAS1 MRTFA	3.61e-04	195	71	5	4300_DN
Drug	Dihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; MCF7; HT_HG-U133A	RC3H2 ARHGEF1 TRIP11 MAP3K12 EPAS1	3.61e-04	195	71	5	7034_UP
Drug	Cyclopenthiazide [742-20-1]; Down 200; 10.6uM; PC3; HT_HG-U133A	RC3H2 CSPP1 TRIP11 RTN2 MAST3	3.61e-04	195	71	5	4229_DN
Drug	Telenzepine dihydrochloride [147416-96-4]; Down 200; 9uM; MCF7; HT_HG-U133A	MXD3 PHLDB1 TMEM134 EVPL ABLIM3	3.69e-04	196	71	5	7419_DN
Drug	Riluzole hydrochloride; Down 200; 14.8uM; MCF7; HT_HG-U133A	ANKEF1 CACNA1H TRIP11 PBXIP1 MAST3	3.69e-04	196	71	5	4689_DN
Drug	Amiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; MCF7; HT_HG-U133A	FAT4 GEMIN8 SCNN1A HUWE1 MXD4	3.69e-04	196	71	5	5253_UP
Drug	Finasteride [98319-26-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	MXD3 RTN2 PBXIP1 EPAS1 BEGAIN	3.69e-04	196	71	5	6062_UP
Drug	alpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A	ZC3H13 TMEM134 LAMA2 NME3 PPP4R3A	3.69e-04	196	71	5	1151_UP
Drug	Nialamide [51-12-7]; Down 200; 13.4uM; PC3; HT_HG-U133A	LAMA2 SORBS1 MAP3K12 MXD4 PPP4R3A	3.69e-04	196	71	5	3790_DN
Drug	Pregnenolone [145-13-1]; Down 200; 12.6uM; MCF7; HT_HG-U133A	MXD3 YTHDC2 TRIP11 MXD4 MAST3	3.69e-04	196	71	5	2856_DN
Drug	Oxalamine citrate salt [1949-20-8]; Up 200; 9.2uM; PC3; HT_HG-U133A	PHLDB1 ZC3H13 YTHDC2 RYR3 PPP4R3A	3.69e-04	196	71	5	6624_UP
Drug	Prednisolone [50-24-8]; Up 200; 11uM; MCF7; HT_HG-U133A	ANKEF1 CACNA1H TRIP11 MAP3K12 MAST3	3.69e-04	196	71	5	7424_UP
Drug	alpha-estradiol; Up 200; 0.01uM; ssMCF7; HG-U133A	GEMIN8 EVPL ABLIM3 CHRNA3 CEMIP2	3.69e-04	196	71	5	403_UP
Drug	Miconazole [22916-47-8]; Down 200; 9.6uM; PC3; HT_HG-U133A	MXD3 RC3H2 YLPM1 MXD4 MRTFA	3.69e-04	196	71	5	6615_DN
Drug	Epitiostanol [2363-58-8]; Down 200; 13uM; HL60; HT_HG-U133A	GEMIN8 TMEM134 MAP3K12 MXD4 MRTFA	3.69e-04	196	71	5	2922_DN
Drug	Methacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A	PHLDB1 GEMIN8 CACNA1H PBXIP1 MRTFA	3.69e-04	196	71	5	7321_UP
Drug	Sulfadimethoxine [122-11-2]; Up 200; 12.8uM; MCF7; HT_HG-U133A	PHLDB1 ZC3H13 YTHDC2 VPS16 PBXIP1	3.69e-04	196	71	5	4724_UP
Drug	Heliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MXD3 EVPL CACNA1H CHRNA3 MRTFA	3.69e-04	196	71	5	4739_DN
Drug	Tubocurarine chloride pentahydrate (+) [6989-98-6]; Up 200; 5.2uM; HL60; HG-U133A	RC3H2 ZC3H13 YLPM1 DIP2C MRTFA	3.69e-04	196	71	5	1738_UP
Drug	Sulfadoxine [2447-57-6]; Up 200; 12.8uM; PC3; HT_HG-U133A	MXD3 GEMIN8 CSPP1 RTN2 MXD4	3.69e-04	196	71	5	5852_UP
Drug	0173570-0000 [211245-44-2]; Up 200; 1uM; MCF7; HT_HG-U133A	PHLDB1 ARHGEF1 CSPP1 PBXIP1 MRTFA	3.78e-04	197	71	5	4715_UP
Drug	Benzethonium chloride [121-54-0]; Down 200; 9uM; MCF7; HT_HG-U133A	EVPL ABLIM3 CEMIP2 PPP4R3A MAST3	3.78e-04	197	71	5	7207_DN
Drug	Yohimbine hydrochloride [65-19-0]; Down 200; 10.2uM; PC3; HT_HG-U133A	YLPM1 EVPL NME3 CSPP1 MAP3K12	3.78e-04	197	71	5	7130_DN
Drug	Tracazolate hydrochloride [41094-88-6]; Up 200; 11.8uM; PC3; HT_HG-U133A	PHLDB1 ARHGEF1 SCNN1A SORBS1 FRMD4B	3.78e-04	197	71	5	6619_UP
Drug	Betahistine mesylate [54856-23-4]; Down 200; 17.2uM; PC3; HT_HG-U133A	MXD3 YLPM1 PBXIP1 MXD4 MRTFA	3.78e-04	197	71	5	6611_DN
Drug	Metrizamide [31112-62-6]; Up 200; 5uM; MCF7; HT_HG-U133A	TGM1 PHLDB1 CACNA1H PCDHGC3 CHRNA3	3.78e-04	197	71	5	4156_UP
Drug	5194442; Down 200; 20uM; PC3; HT_HG-U133A	MXD3 PHLDB1 RTN2 MXD4 MRTFA	3.78e-04	197	71	5	6594_DN
Drug	Ajmaline [4360-12-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	EVPL MAP3K12 CEMIP2 MAST3 BEGAIN	3.78e-04	197	71	5	7484_UP
Drug	Lansoprazole [103577-45-3]; Up 200; 10.8uM; HL60; HT_HG-U133A	MXD3 ARHGEF1 TMEM134 LAMA2 PBXIP1	3.78e-04	197	71	5	2967_UP
Drug	N-Acetyl-L-leucine [1188-21-2]; Down 200; 23uM; PC3; HT_HG-U133A	EVPL NME3 MAP3K12 MRTFA MAST3	3.78e-04	197	71	5	4622_DN
Drug	Promethazine hydrochloride [58-33-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	MXD3 PHLDB1 CSPP1 MAP3K12 EPAS1	3.78e-04	197	71	5	5317_UP
Drug	Disopyramide [3737-09-5]; Down 200; 11.8uM; PC3; HT_HG-U133A	PHLDB1 ANKEF1 EVPL MXD4 MRTFA	3.78e-04	197	71	5	7276_DN
Disease	Odontochondrodysplasia	MIA3 TRIP11	5.39e-06	2	69	2	cv:C2745953
Disease	gestational trophoblastic neoplasm (is_implicated_in)	NLRP7 MEI1	3.22e-05	4	69	2	DOID:3590 (is_implicated_in)
Disease	Complete hydatidiform mole	NLRP7 MEI1	3.22e-05	4	69	2	C0678213
Disease	dystonia (is_implicated_in)	VPS16 TMEM151A	4.82e-04	14	69	2	DOID:543 (is_implicated_in)
Disease	Autosome Abnormalities	XPC EPAS1	6.33e-04	16	69	2	C0004403
Disease	Chromosome Aberrations	XPC EPAS1	6.33e-04	16	69	2	C0008625
Disease	lower face morphology measurement	DCHS2 YTHDC2 EPAS1	2.15e-03	109	69	3	EFO_0010948
Disease	creatinine measurement	CAPN12 MXD3 LAMA2 DIP2C ABLIM3 KIAA1614 EPAS1 MRTFA	2.20e-03	995	69	8	EFO_0004518

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRSKETEVFYELAHE	EPAS1	26	Q99814
DRTRLERHLSQEEFY	ABLIM3	641	O94929
RDRASYEARERHVAE	ARHGEF1	181	Q92888
ASEAEHRLFERLFED	CHRNA3	31	P32297
EFDSTRHYLEIELRR	BEGAIN	31	Q9BUH8
EDTDRYRIRVSAHDS	FAT4	2836	Q6V0I7
LRRERFTHEVDFDDF	ANKEF1	741	Q9NU02
SAHYVERDRFIVTDL	RC3H2	961	Q9HBD1
EEFRTYEALRREHDS	RC3H1	271	Q5TC82
ARERLELYDEHVSSR	UQCRHL	46	A0A096LP55
HRYRRDARTLEDEEE	PPP4R3A	666	Q6IN85
LDRDHDRRLDFTEFL	FLG2	61	Q5D862
YRQHRDAEEALDIFE	KCNC2	156	Q96PR1
EFLERREREAEHGYA	MXD3	16	Q9BW11
EAAEYLERRDREAEH	MXD4	11	Q14582
LERRDREAEHGYASV	MXD4	16	Q14582
TDSFSHRRLYDDRNE	MUC15	266	Q8N387
EELRQYFAETERHRE	GEMIN8	141	Q9NWZ8
RFEDESAREAEFRHL	KIAA1614	451	Q5VZ46
DESNHLTDLYRRDET	PDGFD	41	Q9GZP0
THEERERVRYFHDDD	CWF19L2	581	Q2TBE0
DERFRYESDFDRRLS	CSPP1	331	Q1MSJ5
HVEDYRRFQEEADSV	EVPL	331	Q92817
YEEEAHRRATLENDF	KRT78	201	Q8N1N4
YRLHFERDSREEVER	GNL1	81	P36915
HRTVTREDFLDILYD	LAMA2	1321	P24043
LSRDELRGFLRHYEE	KCNK13	66	Q9HB14
EEDRRAYFLRHFGDE	NLRP2	361	Q9NX02
DYEDRREFELTAHIS	PCDHGC3	526	Q9UN70
VRRDHVFEDSYRELH	HUWE1	4021	Q7Z6Z7
RDTLEVSEFFRRHEV	ITPKA	381	P23677
REEEAALLFERAHYR	MEI1	16	Q5TIA1
IREETLREVRDSHFF	THAP12	246	O43422
LDRERRDHYSFVAAT	DCHS2	131	Q6V1P9
RDYSRSFHEDEVDRV	FRMD4B	851	Q9Y2L6
DEADFTLRVFSERRH	CAPN12	511	Q6ZSI9
TDFYRHQIEEELDRR	HTT	3096	P42858
SDYRFLEDVARTADH	ZNHIT6	276	Q9NWK9
GSRDERYRSDVHTEA	DIP2C	81	Q9Y2E4
ESERFDTHEYRNESR	CEMIP2	281	Q9UHN6
REELRHALDIREHYE	MAP3K12	416	Q12852
RSERYRHLGSEDDET	MAST3	671	O60307
SDFFLRIDSHREDAA	CACNA1H	1226	O95180
ARLSTRHTEFEEREY	CDH17	726	Q12864
VYRDLEFEEDQREHR	DNAH2	771	Q9P225
EALIEFHRSYRELFE	SCNN1A	46	P37088
FELTPEEEHVERFRY	PROCA1	131	Q8NCQ7
SFETERDHLRGYIRE	CENPE	1211	Q02224
SEELLREHYAELRER	NME3	61	Q13232
DSAFTEPRYHVRRED	POTEA	51	Q6S8J7
DSDFRELHTAREFSE	RTN2	31	O75298
TDFIREEYHKRDFTE	TARS3	436	A2RTX5
EERPRTREEECHFYA	PRDX4	41	Q13162
EEYERQEREHRLSAA	MIA3	1541	Q5JRA6
EEDRRAYFLRHFGDE	NLRP7	326	Q8WX94
HERADSRTARGEFDY	TMEM151A	181	Q8N4L1
HEQRRSLERARTEDY	MRTFA	11	Q969V6
YFRALLDDHFRESEE	ABTB1	296	Q969K4
ARYDFSHEILRDEES	ALKBH7	171	Q9BT30
HDRLRFRDFVDALED	PBXIP1	651	Q96AQ6
RYSHRDTDEEVREHL	RYR3	3396	Q15413
HFTTRNRDYDDIDDD	TTYH2	416	Q9BSA4
DYLESTEEFIRRRHD	SORBS1	721	Q9BX66
SFHIRASYAAEERIE	VPS16	631	Q9H269
FLDRTEELALSHYRE	VIPAS39	246	Q9H9C1
EISDNEDDLLEYHRR	PHLDB1	581	Q86UU1
ETEHAGQRDRYDRER	YLPM1	1676	P49750
DEVHERDRFSDFLLT	YTHDC2	316	Q9H6S0
SRRHREELSDYEERI	TRIP11	251	Q15643
RREHHTDEYEYDELI	TGM1	126	P22735
LHFERRARFEVADED	TMEM134	36	Q9H6X4
RFAIYSARDDEELVH	XPC	286	Q01831
TRDAHDYRDREGRDT	ZC3H13	501	Q5T200
HIDRVYRDDTFVGRS	KIAA1522	236	Q9P206