Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionneutral L-amino acid:sodium symporter activity

SLC38A2 SLC38A4 SLC38A3

5.74e-068953GO:0005295
GeneOntologyMolecularFunctionalanine transmembrane transporter activity

SLC38A2 SLC38A4 SLC38A3

5.59e-0516953GO:0022858
GeneOntologyMolecularFunctioncarbon-sulfur lyase activity

CENPVL2 CENPVL3 CENPVL1

5.59e-0516953GO:0016846
GeneOntologyMolecularFunctionalanine:sodium symporter activity

SLC38A2 SLC38A4

1.34e-044952GO:0015655
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC38A2 SLC38A4 SLC38A3

1.72e-0423953GO:0005283
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC38A2 SLC38A4 SLC38A3

3.48e-0429953GO:0005416
GeneOntologyMolecularFunctionlyase activity

APIP CENPVL2 RNASE1 CENPVL3 GUCY1A1 CENPVL1

5.29e-04212956GO:0016829
GeneOntologyMolecularFunctionL-glutamine transmembrane transporter activity

SLC38A2 SLC38A3

7.89e-049952GO:0015186
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC38A2 SLC38A4 SLC38A3

9.75e-0441953GO:0015175
DomainActin

ACTL8 ACTBL2 ACTG2 ACTR2

1.50e-0531914IPR004000
DomainActin

ACTL8 ACTBL2 ACTG2 ACTR2

1.50e-0531914PF00022
DomainACTIN

ACTL8 ACTBL2 ACTG2 ACTR2

1.50e-0531914SM00268
DomainKinase-like_dom

TRPM6 MET PIK3C2B IKBKE SGK1 TESK2 SMARCC1 MACF1 KDR PRKDC EPHA1

6.45e-055429111IPR011009
DomainAa_trans

SLC38A2 SLC38A4 SLC38A3

7.24e-0517913PF01490
DomainAA_transpt_TM

SLC38A2 SLC38A4 SLC38A3

7.24e-0517913IPR013057
DomainActin/actin-like_CS

ACTBL2 ACTG2 ACTR2

8.66e-0518913IPR020902
DomainACTINS_ACT_LIKE

ACTBL2 ACTG2 ACTR2

1.02e-0419913PS01132
DomainACTINS_1

ACTBL2 ACTG2

6.45e-048912PS00406
DomainRecF/RecN/SMC_N

SMC5 SMC1B

6.45e-048912IPR003395
DomainSMC_N

SMC5 SMC1B

6.45e-048912PF02463
DomainVWF_dom

VWF PXDNL OTOG

1.12e-0342913IPR001007
DomainPROTEIN_KINASE_TYR

MET TESK2 KDR EPHA1

1.29e-0397914PS00109
DomainTyr_kinase_AS

MET TESK2 KDR EPHA1

1.29e-0397914IPR008266
DomainARM-type_fold

IPO7 PIK3C2B PRKDC WDFY3 HUWE1 PPP4R4 RYR3

1.34e-03339917IPR016024
DomainC8

VWF OTOG

1.50e-0312912PF08742
DomainTIL

VWF OTOG

1.50e-0312912PF01826
DomainUnchr_dom_Cys-rich

VWF OTOG

1.77e-0313912IPR014853
DomainC8

VWF OTOG

1.77e-0313912SM00832
DomainTIL_dom

VWF OTOG

2.06e-0314912IPR002919
DomainEF-hand_like

PLCB2 PLCL1

2.37e-0315912PF09279
DomainPI-PLC-Y

PLCB2 PLCL1

2.37e-0315912PF00387
DomainPLCYc

PLCB2 PLCL1

2.37e-0315912SM00149
DomainPI3/4_kinase_CS

PIK3C2B PRKDC

2.37e-0315912IPR018936
DomainPLipase_C_Pinositol-sp_Y

PLCB2 PLCL1

2.37e-0315912IPR001711
DomainPIPLC_Y_DOMAIN

PLCB2 PLCL1

2.37e-0315912PS50008
DomainPI-PLC_fam

PLCB2 PLCL1

2.37e-0315912IPR001192
DomainPLC_EF-hand-like

PLCB2 PLCL1

2.37e-0315912IPR015359
DomainVWF_type-D

VWF OTOG

2.70e-0316912IPR001846
Domain-

PIK3C2B PRKDC

2.70e-03169121.10.1070.11
DomainVWFD

VWF OTOG

2.70e-0316912PS51233
DomainPI3Kc

PIK3C2B PRKDC

2.70e-0316912SM00146
DomainVWD

VWF OTOG

2.70e-0316912SM00216
DomainActin_CS

ACTBL2 ACTG2

2.70e-0316912IPR004001
DomainVWD

VWF OTOG

2.70e-0316912PF00094
Domain-

IGFBP4 TG

3.04e-03179124.10.800.10
DomainThyroglobulin_1

IGFBP4 TG

3.04e-0317912IPR000716
DomainTHYROGLOBULIN_1_1

IGFBP4 TG

3.04e-0317912PS00484
DomainACTINS_2

ACTBL2 ACTG2

3.04e-0317912PS00432
DomainTY

IGFBP4 TG

3.04e-0317912SM00211
DomainTHYROGLOBULIN_1_2

IGFBP4 TG

3.04e-0317912PS51162
DomainThyroglobulin_1

IGFBP4 TG

3.04e-0317912PF00086
DomainPI3_PI4_kinase

PIK3C2B PRKDC

3.41e-0318912PF00454
DomainPI3_4_KINASE_1

PIK3C2B PRKDC

3.41e-0318912PS00915
DomainPI3_4_KINASE_2

PIK3C2B PRKDC

3.41e-0318912PS00916
DomainPI-PLC-X

PLCB2 PLCL1

3.41e-0318912PF00388
DomainPLCXc

PLCB2 PLCL1

3.41e-0318912SM00148
DomainPI3/4_kinase_cat_dom

PIK3C2B PRKDC

3.41e-0318912IPR000403
DomainPI3_4_KINASE_3

PIK3C2B PRKDC

3.41e-0318912PS50290
DomainPkinase_Tyr

MET TESK2 KDR EPHA1

3.65e-03129914PF07714
DomainVWC_out

VWF OTOG

3.80e-0319912SM00215
DomainPIPLC_X_DOMAIN

PLCB2 PLCL1

3.80e-0319912PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCB2 PLCL1

3.80e-0319912IPR000909
DomainSer-Thr/Tyr_kinase_cat_dom

MET TESK2 KDR EPHA1

4.64e-03138914IPR001245
DomainPH_dom-like

ANKS1B PLCB2 PLCL1 WDFY3 EPB41L3 SH2D5 MTMR9

4.78e-03426917IPR011993
PathwayKEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY

PLCB2 TSHB TG

2.95e-0512743M47628
Pubmed

Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.

CENPVL2 CENPVL3 CENPVL1

3.93e-07695327250503
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

IPO7 STRAP SMARCC1 BEND3 CHD3 NUP214 HUWE1 GTF3C3 ZFPM2

5.76e-0646995927634302
Pubmed

Anlotinib, a novel small molecular tyrosine kinase inhibitor, suppresses growth and metastasis via dual blockade of VEGFR2 and MET in osteosarcoma.

MET KDR

7.38e-06295230719715
Pubmed

Thrombin-mediated in vitro processing of pro-von Willebrand factor.

VWF F2

7.38e-06295211776313
Pubmed

The role of c-Met and VEGFR2 in glioblastoma resistance to bevacizumab.

MET KDR

7.38e-06295233727583
Pubmed

Epac1 regulates TLR4 signaling in the diabetic retinal vasculature.

RAPGEF3 TLR4

7.38e-06295234020266
Pubmed

Flow and delta-P dictate where thrombin, fibrin, and von Willebrand Factor will be found.

VWF F2

7.38e-06295227207416
Pubmed

Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB.

SGK1 SLC38A3

7.38e-06295212788082
Pubmed

The mechanism of melanoma-associated thrombin activity and von Willebrand factor release from endothelial cells.

VWF F2

7.38e-06295220505748
Pubmed

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis.

EFNB2 KDR

7.38e-06295220445540
Pubmed

Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's disease.

TLR4 F2

7.38e-06295226440368
Pubmed

An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury.

TLR4 KDR

7.38e-06295226655705
Pubmed

Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients.

MET KDR

7.38e-06295227789775
Pubmed

HMQ-T-B10 induces human liver cell apoptosis by competitively targeting EphrinB2 and regulating its pathway.

EFNB2 KDR

7.38e-06295230589500
Pubmed

Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta.

PRKDC F2

7.38e-06295227442243
Pubmed

Thrombin generation in the presence of platelets is sensitive to the activation status of von Willebrand factor.

VWF F2

7.38e-06295225274249
Pubmed

A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities.

MET KDR

7.38e-06295223548264
Pubmed

MASP-1 of the complement system promotes clotting via prothrombin activation.

MASP1 F2

7.38e-06295225745807
Pubmed

EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development.

EFNB2 KDR

7.38e-06295231868584
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ACTBL2 LPCAT4 MARF1 ANKS1B SMARCC1 ACTG2 BEND3 MACF1 KDR CHD3 PRKDC EPB41L3 ACTR2 PPP4R4 RING1

8.36e-061442951535575683
Pubmed

Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.

SLC38A2 SLC38A4 SLC38A3

8.77e-061595323506890
Pubmed

Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.

EFNB2 KDR ZFPM2

8.77e-061595323797856
Pubmed

Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis.

EFNB2 SGK1 KDR

8.77e-061595320568246
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

APEX2 PIK3C2B IKBKE UBA6 NUP214 EPB41L3 SMC5 F2 RYR3

9.16e-0649795936774506
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IPO7 SMARCC1 BEND3 MACF1 NUP214 PRKDC HUWE1 EPB41L3 ACTR2 GTF3C3

1.23e-05653951022586326
Pubmed

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

SMARCC1 BEND3 PRKDC GTF3C3 RING1

1.73e-0511695521549307
Pubmed

SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development.

EFNB2 SMARCC1 KDR

1.85e-051995318206867
Pubmed

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.

SLC38A2 IPO7 ACTBL2 PRKDC ACTR2

1.87e-0511895527377895
Pubmed

FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells.

VWF EFNB2 KDR

2.18e-052095325091710
Pubmed

Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model.

VWF F2

2.21e-05395217380206
Pubmed

Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2.

VWF TLR4

2.21e-05395228572286
Pubmed

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.

VWF KDR

2.21e-0539527681362
Pubmed

Effects of toll-like receptor-4 gene polymorphisms on soluble P-selectin and von Willebrand factor levels in hypercholesterolemic patients.

VWF TLR4

2.21e-05395217849054
Pubmed

Revisiting Libman-Sacks endocarditis: a historical review and update.

PLCB2 F2

2.21e-05395219089657
Pubmed

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

RAPGEF3 PRKDC

2.21e-05395218728186
Pubmed

Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth factor receptor MET.

MET TLR4

2.21e-05395224567328
Pubmed

Antenatal dexamethasone treatment in midgestation reduces system A-mediated transport in the late-gestation murine placenta.

SLC38A2 SLC38A4

2.21e-05395221733830
Pubmed

Cardiovascular ephrinB2 function is essential for embryonic angiogenesis.

EFNB2 KDR

2.21e-05395211880349
Pubmed

Co-localization of prothrombin fragment F1+2 and VEGF-R2-bound VEGF in human colon cancer.

KDR F2

2.21e-05395221498704
Pubmed

NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.

TLR4 PRKDC

2.21e-05395236801998
Pubmed

MET Suppresses Epithelial VEGFR2 via Intracrine VEGF-induced Endoplasmic Reticulum-associated Degradation.

MET KDR

2.21e-05395226137585
Pubmed

The c-MET receptor tyrosine kinase contributes to neutrophil-driven pathology in cutaneous leishmaniasis.

MET TLR4

2.21e-05395235041723
Pubmed

HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response.

PRKDC HUWE1

2.21e-05395232457294
Pubmed

Lymphangiogenesis in the developing lung promoted by VEGF-A.

EFNB2 KDR

2.21e-05395216806288
Pubmed

Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways.

VWF KDR

2.21e-05395219570985
Pubmed

Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors.

MET KDR

2.21e-05395227922668
Pubmed

A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis.

MET KDR

2.21e-05395219773544
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TRPM6 SLC38A2 IPO7 PITRM1 STRAP UBA6 SMARCC1 NUP214 PRKDC HUWE1 EPB41L3 F2 ACTR2 GTF3C3

3.23e-051425951430948266
Pubmed

Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium.

EFNB2 KDR ZFPM2

3.83e-052495325497097
Pubmed

Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.

MET KDR EPHA1

4.35e-052595315254900
Pubmed

Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development.

EFNB2 KDR HNF4A

4.35e-052595336046192
Pubmed

Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection.

TLR4 ALOX5

4.41e-05495219299700
Pubmed

The evolution of SMC proteins: phylogenetic analysis and structural implications.

SMC5 SMC1B

4.41e-05495214660695
Pubmed

Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes.

SLC38A2 SLC38A4

4.41e-05495217050538
Pubmed

Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer.

MET KDR

4.41e-05495228973887
Pubmed

VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex.

MET KDR

4.41e-05495222789536
Pubmed

A pilot study on prostate cancer risk and pro-inflammatory genotypes: pathophysiology and therapeutic implications.

TLR4 ALOX5

4.41e-05495220388081
Pubmed

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

MET KDR EPHA1

6.16e-052895318593464
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

STRAP NETO1 NISCH ANKS1B UBA6 SMARCC1 MACF1 PLCL1 WDFY3 HUWE1 EPB41L3

6.50e-05963951128671696
Pubmed

Differential expression of vascular endothelial growth factor and its receptor mRNAs in the mouse uterus around the time of implantation.

VWF KDR

7.34e-0559527490564
Pubmed

Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.

EFNB2 KDR

7.34e-05595225051267
Pubmed

Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.

VWF F2

7.34e-05595216824188
Pubmed

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.

TLR4 ALOX5

7.34e-05595224889202
Pubmed

Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden.

TLR4 PRKDC

7.34e-05595216428731
Pubmed

Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer.

F2 HNF4A

7.34e-05595212911579
Pubmed

Analysis of the effects of HIV-1 Tat on the survival and differentiation of vessel wall-derived mesenchymal stem cells.

VWF KDR

7.34e-05595222095559
Pubmed

Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.

SLC38A2 SLC38A4

7.34e-05595216365304
Pubmed

Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling.

MET KDR

7.34e-05595222897854
Pubmed

Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.

EFNB2 PRKDC

7.34e-05595238569552
Pubmed

NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function.

STRAP SGK1

7.34e-05595217916563
Pubmed

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.

TLR4 PRKDC

7.34e-05595236868208
Pubmed

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.

TLR4 PRKDC

7.34e-05595223223360
Pubmed

Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment.

SLC38A2 SLC38A4

7.34e-05595218703994
Pubmed

A role for APPL1 in TLR3/4-dependent TBK1 and IKKε activation in macrophages.

IKBKE TLR4

7.34e-05595225780039
Pubmed

Amino acid transport across mammalian intestinal and renal epithelia.

SLC38A2 SLC38A4 SLC38A3

8.40e-053195318195088
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

CACNA1D HUWE1 EPB41L3

1.01e-043395322357600
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

SGK1 DECR2 CHD3 HUWE1 OTOG

1.07e-0417095523314748
Pubmed

Dosage-sensitive requirement for mouse Dll4 in artery development.

EFNB2 KDR

1.10e-04695215466159
Pubmed

A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors.

IKBKE KDR

1.10e-04695224184958
Pubmed

Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors.

KDR ZFPM2

1.10e-04695211297508
Pubmed

Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.

TLR4 PRKDC

1.10e-04695222902233
Pubmed

Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling.

RAPGEF3 KDR

1.10e-04695223886837
Pubmed

Arteriovenous malformations in mice lacking activin receptor-like kinase-1.

EFNB2 KDR

1.10e-04695211062473
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

RNF123 UBA6 HUWE1 RING1

1.37e-049595429643511
Pubmed

Abnormal blood vessel development in mice lacking presenilin-1.

EFNB2 KDR

1.54e-04795212834865
Pubmed

Advancements and challenges in generating accurate animal models of gestational diabetes mellitus.

MET HNF4A

1.54e-04795224085033
Pubmed

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).

MET PRKDC

1.54e-04795224870234
Pubmed

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.

EFNB2 KDR

1.54e-0479529990854
Pubmed

TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kβ, SGK1, and FOXO transcription factors.

SGK1 TLR4

1.54e-04795228733463
Pubmed

Spatial regulation of VEGF receptor endocytosis in angiogenesis.

EFNB2 KDR

1.54e-04795223354168
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

MET RNF123 STRAP IKBKE SGK1 SMARCC1 BCAR3 RUNX1T1 EPB41L3 HNF4A ACTR2 GTF3C3

1.97e-041284951217353931
Pubmed

HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells.

VWF KDR

2.05e-04895221612582
Pubmed

Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice.

SLC38A2 SLC38A4

2.05e-04895231570606
Pubmed

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.

VWF EFNB2

2.05e-04895218245384
Pubmed

The identification of different endothelial cell populations within the mouse proepicardium.

KDR HNF4A

2.05e-04895221932312
Pubmed

Temporally compartmentalized expression of ephrin-B2 during renal glomerular development.

EFNB2 KDR

2.05e-04895211729236
Pubmed

Eph:ephrin-B1 forward signaling controls fasciculation of sensory and motor axons.

EFNB2 EPHA1

2.05e-04895224056079
Pubmed

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

ACTBL2 ACTG2 ACTR2

2.25e-044395320876399
Pubmed

Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling.

TLR4 ALOX5

2.62e-04995223112187
Pubmed

Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.

TLR4 PRKDC

2.62e-04995216239576
CytobandXp11.22

CENPVL2 CENPVL3 HUWE1 CENPVL1

5.03e-0654954Xp11.22
CytobandEnsembl 112 genes in cytogenetic band chr3p21

CACNA1D RNF123 NISCH SMARCC1 SLC38A3

5.23e-04316955chr3p21
GeneFamilyStructural maintenance of chromosomes proteins|Cohesin complex

SMC5 SMC1B

2.98e-047692761
CoexpressionWOOD_EBV_EBNA1_TARGETS_DN

IPO7 SGK1 MACF1 EPB41L3 ACTR2

7.25e-0748925M19460
CoexpressionBOQUEST_STEM_CELL_DN

MET RNASE1 VWF EFNB2 PIK3C2B LPCAT4 KDR BCAR3

1.03e-06218928M1578
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HENDO

SLC38A2 RNASE1 VWF EFNB2 PLA2G4C IGFBP4 STARD4 IKBKE RAPGEF3 SGK1 TLR4 KDR SLC38A3

1.34e-058889213M39049
CoexpressionMENON_FETAL_KIDNEY_9_ENDOTHELIAL_CELLS

RNASE1 EFNB2 IGFBP4 KDR ACTR2

3.04e-05102925M39259
CoexpressionAIZARANI_LIVER_C10_MVECS_1

RNASE1 VWF EFNB2 IGFBP4 SGK1 KDR RUNX1T1

4.62e-05269927M39114
CoexpressionGSE34156_TLR1_TLR2_LIGAND_VS_NOD2_AND_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_DN

GUCY1A1 IKBKE NISCH DECR2 LRRC14 PM20D2

4.91e-05185926M8680
CoexpressionAIZARANI_LIVER_C13_LSECS_2

RNASE1 EFNB2 IGFBP4 SGK1 NISCH TLR4 KDR

6.36e-05283927M39117
CoexpressionGSE25088_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_STAT6_KO_MACROPHAGE_UP

SLC38A2 CACNA1D IPO7 SMARCC1 PRKDC HUWE1

6.96e-05197926M8022
CoexpressionGSE15659_CD45RA_NEG_CD4_TCELL_VS_ACTIVATED_TREG_DN

TRPM6 STARD4 TLR4 UBA6 PLCB2 TGM6

7.16e-05198926M3557
CoexpressionGSE15659_CD45RA_NEG_CD4_TCELL_VS_NONSUPPRESSIVE_TCELL_DN

TRPM6 PXDNL TLR4 UBA6 PLCB2 TGM6

7.36e-05199926M3554
CoexpressionAIZARANI_LIVER_C32_MVECS_3

SLC38A2 RNASE1 VWF SGK1 TLR4

8.03e-05125925M39131
CoexpressionMIKKELSEN_MEF_LCP_WITH_H3K4ME3

MASP1 RNF123 IKBKE TLR4 ACTG2

8.99e-05128925M1966
ToppCellLPS_only-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 PLA2G4C RGS7BP PIK3C2B KDR BCAR3 ZFPM2

3.65e-1019495958f069efdefa0366033764446b9d6ffd4a17807e
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 PLA2G4C RGS7BP PIK3C2B KDR BCAR3 ZFPM2

3.65e-10194959bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP PIK3C2B MACF1 KDR ZFPM2

9.12e-091949580b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 PLA2G4C RGS7BP PIK3C2B KDR BCAR3

9.49e-0919595856efeb58df19f357d7d5ce87348d4f196a595421
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 SGK1 TLR4 KDR RUNX1T1

1.16e-08200958b1be27d134a8633e3e7862c6a0d7be2001d387f0
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 SGK1 TLR4 KDR RUNX1T1

1.16e-08200958ced14d83222dbebca85c40540e76824e683354f3
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF EFNB2 PLA2G4C RGS7BP PIK3C2B KDR BCAR3

1.44e-07185957808d5e880069aff8866cd2c733b9fe568a37701f
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF EFNB2 PLA2G4C RGS7BP PIK3C2B KDR BCAR3

1.55e-07187957dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP PIK3C2B KDR ZFPM2

1.93e-07193957af5108260783e69a7d67896c5bf64f862525926d
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

RNASE1 VWF EFNB2 IGFBP4 PIK3C2B RAPGEF3 KDR

2.06e-07195957a432d69b0172211ee4d53675936a1dc9ce1ae1f0
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 PIK3C2B RAPGEF3 KDR

2.14e-07196957ae46d4b00be92e64e46252dcc156161b171eded4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 PIK3C2B KDR RUNX1T1 ADARB1 RYR3

2.14e-071969578ad8efb631164b46f0c082572270188e5ead20bf
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 IGFBP4 PIK3C2B KDR RUNX1T1 RYR3

2.14e-0719695722767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 PIK3C2B KDR RUNX1T1 ADARB1 RYR3

2.14e-071969579606ea7e42f707e69ea891b3521037613b9675f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 IGFBP4 PIK3C2B KDR RUNX1T1 RYR3

2.14e-07196957adee900dcd16dbaba15c58bdcace09ba20214950
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 SGK1 KDR RUNX1T1 ADARB1 RYR3

2.21e-07197957cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 PIK3C2B SGK1 KDR RUNX1T1 RYR3

2.29e-0719895707701c73137947ed4a27e225975329235bbb8734
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 PIK3C2B KDR RUNX1T1

2.29e-07198957953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 PIK3C2B SGK1 KDR RUNX1T1 RYR3

2.29e-07198957fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 PIK3C2B KDR RUNX1T1

2.29e-071989578e45551224fbb30c0658ad47dd98335ecf165437
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 PIK3C2B RAPGEF3 KDR

2.37e-07199957b15304d3d3f6c254969b54a61bee3d9f368840b2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 SGK1 KDR RUNX1T1

2.37e-071999578b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 SGK1 KDR RUNX1T1

2.37e-07199957da5a88749d859d535daa030d0974485906cc0ba7
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RNASE1 VWF PLA2G4C RGS7BP PIK3C2B MACF1 KDR

2.45e-072009572d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

RNASE1 VWF PLA2G4C RGS7BP PIK3C2B MACF1 KDR

2.45e-0720095781e76508c9050d533853d5fd2f3097b27613d836
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 SGK1 KDR RUNX1T1

2.45e-07200957dba96cda5f3b780a3d4171b61bc8aaddc1f5d466
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 SGK1 KDR RUNX1T1

2.45e-072009577a69ad5b6c84f1aebacea5cacb9bc5c63dfd1dac
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

RNASE1 VWF PLA2G4C RGS7BP PIK3C2B MACF1 KDR

2.45e-072009574bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCellLPS-IL1RA-Endothelial-Epi-like-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 APEX2 ACTG2 EPB41L3 HNF4A EPHA1

5.18e-071389565f8ac8f67e34a7cf560099208e6884102532391e
ToppCelldroplet-Heart-nan-3m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFNB2 SGK1 UBA6 KDR NUP214 ADARB1

1.10e-06157956d85a2f56ae313baa9738e81d2756ce1fe1ba50db
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPM6 VWF RAPGEF3 LPCAT4 RUNX1T1 ZFPM2

1.58e-06167956d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 SGK1 KDR

1.64e-0616895637249f38f8f04ec5743097259de67b106ca2b02f
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D VWF IGFBP4 MACF1 KDR ADARB1

1.75e-061709567fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PXDNL ANKS1B ACTG2 PLCL1 ADARB1 ZFPM2

1.94e-06173956cb6389536195443633adb06e5f1b7483530773d1
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF IGFBP4 NETO1 KDR ADARB1

2.44e-0618095697e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPM6 MASP1 VWF RAPGEF3 RUNX1T1 ZFPM2

2.44e-0618095627e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 RAPGEF3 KDR

2.60e-061829560346f81bbb1f309f3e9d063b20547d548d09472c
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 RAPGEF3 KDR

2.77e-06184956842473fa415575441b595073a994b6d621169776
ToppCellP03|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D IGFBP4 NISCH MACF1 ADARB1 EPHA1

2.86e-06185956a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPM6 VWF RAPGEF3 LPCAT4 RUNX1T1 ZFPM2

3.04e-06187956e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 NETO1 KDR

3.04e-061879560ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 IGFBP4 SGK1 KDR

3.04e-06187956a555a4af7946dec14a6b176ace4a4c2ecfd7f59e
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 RAPGEF3 KDR

3.04e-0618795625efb82afe863a853ecdd781ad89026c993aaa67
ToppCellwk_08-11-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

VWF EFNB2 IGFBP4 PIK3C2B NETO1 KDR

3.04e-06187956a27aa97aa6508a3ffe92c2b6bb0511a95650a390
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

VWF EFNB2 IGFBP4 PIK3C2B RAPGEF3 KDR

3.14e-06188956366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

RGS7BP ANKS1B ACTG2 MACF1 ADARB1 RYR3

3.14e-0618895634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 RAPGEF3 KDR

3.14e-061889560026c9479b30fb39daa91cfa220a88f9c9e65fe7
ToppCellFibroblast-A|World / shred on cell class and cell subclass (v4)

CACNA1D IGFBP4 MACF1 RUNX1T1 ADARB1 PPP4R4

3.14e-061889566740bed5fb8f45b6eea17041894b804214c2a4ae
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 RAPGEF3 KDR

3.23e-06189956db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

RGS7BP ANKS1B ACTG2 MACF1 ADARB1 RYR3

3.23e-061899566b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP GUCY1A1 KDR

3.23e-06189956e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 EFNB2 PLA2G4C GUCY1A1 PIK3C2B KDR

3.33e-06190956474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 PIK3C2B RUNX1T1 ADARB1 RYR3

3.44e-06191956b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 PLA2G4C PIK3C2B KDR

3.44e-06191956a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF IGFBP4 RAPGEF3 LPCAT4 EPB41L3 RYR3

3.54e-06192956eafead22bba48ac5ee568faa8946c444445c1034
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-immature_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VWF IGFBP4 RAPGEF3 KDR SLC38A3 ZFPM2

3.54e-061929565af3b2b38495e925497c48f605d618bbf970965d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF IGFBP4 RGS7BP PIK3C2B RYR3

3.54e-061929561ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellLPS-IL1RA+antiTNF-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP PIK3C2B KDR

3.54e-0619295604f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF EFNB2 RGS7BP PIK3C2B KDR BCAR3

3.54e-061929560aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP PIK3C2B KDR

3.54e-06192956c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF IGFBP4 RGS7BP KDR RYR3

3.54e-0619295625cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

VWF EFNB2 PIK3C2B NETO1 RAPGEF3 KDR

3.54e-061929568a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D IGFBP4 NISCH MACF1 ADARB1 EPHA1

3.54e-061929560afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCellfacs-Brain_Non-Myeloid-Striatum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NETO1 NISCH ANKS1B EPB41L3 SH2D5 RYR3

3.65e-06193956d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCellLPS-antiTNF-Endothelial-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP PIK3C2B KDR

3.65e-0619395602f633b016ab19bfa65bfd0cf32f000549a62148
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D IGFBP4 NISCH MACF1 ADARB1 PPP4R4

3.65e-061939568d05805295c5d3aa93aeb38be5fbefa81e1be1f0
ToppCellLPS-antiTNF-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP PIK3C2B KDR

3.65e-061939565122b1ffba42de190061be34ecdc6176f84e56a3
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D IGFBP4 NISCH MACF1 ADARB1 PPP4R4

3.65e-061939561b2cc627b2aa002b442358bd1188d470e67ce7d9
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VWF EFNB2 IGFBP4 RGS7BP PIK3C2B RYR3

3.65e-06193956287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 PIK3C2B KDR RUNX1T1

3.76e-06194956f76808666fb875fc787751cbfd924d9be20a8192
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP PIK3C2B KDR

3.76e-0619495643f92b0533e26633dc94cce554045d641ef8fd76
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNASE1 VWF EFNB2 RGS7BP PIK3C2B KDR

3.76e-061949561d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 IGFBP4 RGS7BP PIK3C2B KDR RUNX1T1

3.76e-06194956b490fffc94f005dff9a34ce34d80ca776e3a1387
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 VWF EFNB2 PIK3C2B KDR RUNX1T1

3.76e-06194956f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCellControl-Endothelial|Control / Disease state, Lineage and Cell class

VWF EFNB2 IGFBP4 KDR RUNX1T1 ZFPM2

3.76e-06194956485fe5538fabec457b9a51feb641f2a91cbf4e18
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D IGFBP4 NISCH MACF1 ADARB1 PPP4R4

3.87e-06195956b616ee6f1d878935d293c8e0a8bbc5b4385301f0
ToppCellbackground-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

RNASE1 VWF IGFBP4 RGS7BP KDR RUNX1T1

3.87e-06195956c7d60dabfc7cb310e002cab10003dadfcc34fe33
ToppCellLV-09._Endothelium_I|World / Chamber and Cluster_Paper

VWF EFNB2 RAPGEF3 SGK1 KDR RUNX1T1

3.87e-0619595619e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D NISCH MACF1 HUWE1 ZCCHC7 EPB41L3

3.87e-061959563e519cffa6144a62b06124642a14c9ff39b76554
ToppCellChildren_(3_yrs)-Endothelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

VWF EFNB2 PLA2G4C KDR RUNX1T1 ZFPM2

3.87e-06195956094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D NISCH MACF1 HUWE1 ZCCHC7 EPB41L3

3.87e-061959567796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellPND07-Mesenchymal-Mesenchymal_structural|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D IGFBP4 NISCH MACF1 ADARB1 PPP4R4

3.87e-061959562f9a274b26fc528a85f50933ec2f4db1dc9da0ca
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 EFNB2 IGFBP4 SGK1 TLR4 KDR

3.99e-06196956d323f7dc41380446e5967c69832bea88351a9331
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNASE1 EFNB2 IGFBP4 SGK1 TLR4 KDR

3.99e-0619695665d882c6e7f6d5778b8a5fd4fdaf012e1b9f6100
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D IGFBP4 MACF1 RUNX1T1 ADARB1 PPP4R4

3.99e-061969562a885eed52f9b002c7995e11e450c7e8d7ae69e6
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D IGFBP4 MACF1 RUNX1T1 ADARB1 PPP4R4

3.99e-0619695614246f00c90741a5f8683f377e22e3a7c99661b9
ToppCellMatrixFB|World / shred on cell class and cell subclass (v4)

CACNA1D IGFBP4 GUCY1A1 ACTG2 MACF1 ADARB1

4.11e-06197956e325de44e32021a36fffb7b7e88167b46bb051c7
ToppCellPND03-Mesenchymal|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D IGFBP4 GUCY1A1 ACTG2 MACF1 ADARB1

4.11e-06197956e3053ef8f604b6892c21c03e12612b49d3d30f23
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

VWF EFNB2 IGFBP4 KDR RUNX1T1 ZFPM2

4.11e-06197956ebf9be068eaa658493fa7884fd19f34642922acb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF SGK1 KDR RUNX1T1 ADARB1 RYR3

4.11e-06197956412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 TLR4 KDR

4.11e-06197956b18f2c14d6720f6ae8520c0800356f4a57393ad3
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNASE1 VWF EFNB2 IGFBP4 PIK3C2B RUNX1T1

4.23e-061989561b9200e30f1d9b91bb0c6411c4f95208aedbe161
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 GUCY1A1 RAPGEF3

4.23e-061989568a55589b9244283e4b0b423a4a6d6202e8e0fec9
ToppCellILEUM-inflamed-(7)_CD36+_endothelial_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RNASE1 VWF EFNB2 IGFBP4 RAPGEF3 KDR

4.23e-0619895605d6558c7990ad2277db999025a073d29b273dfc
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 GUCY1A1 RAPGEF3

4.23e-06198956d1f54ed3ef5e05ebda7da999e172d168dc6802cd
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 RAPGEF3 KDR

4.23e-06198956e9e98c20ff7b3f3851db86381550ce7085e2db9e
ToppCell5'-Adult-Distal_Rectal-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 GUCY1A1 RAPGEF3

4.23e-061989568d6b0b9da7c1e64155cbcbb04ad38d129a29030c
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNASE1 VWF EFNB2 IGFBP4 PIK3C2B RUNX1T1

4.23e-061989567e2d6e21b2b3d5a4a9f786890ec6ba2688a506cc
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNASE1 VWF EFNB2 IGFBP4 PIK3C2B RUNX1T1

4.23e-0619895655378e15360f867c9500b03293814965562ae55d
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE1 VWF EFNB2 IGFBP4 RAPGEF3 KDR

4.23e-06198956f7a957e8f09d54a55a5dbecfaa9cdf01e6fd543d
DrugAC1OAGGW

ACTL8 PIK3C2B ACTBL2 ACTG2 PLCB2 EPB41L3 F2 TG

1.57e-06203918CID006857364
DrugAC1MU1S9

ACTL8 GUCY1A1 PIK3C2B NETO1 SGK1 ACTBL2 ACTG2 PLCB2 TSHB NUP214 F2 ALOX5

2.92e-065729112CID000003733
Drugwartmannin

SLC38A2 MET ACTL8 STRAP PIK3C2B RAPGEF3 SGK1 SLC38A4 ACTBL2 ACTG2 KDR PRKDC F2 TG

3.97e-068119114CID000005691
DrugAC1Q5THZ

VWF ACTL8 ACTBL2 TLR4 ACTG2 PLCB2 NUP214 F2 ALOX5 PADI1 TG

5.18e-065029111CID000001959
Druglithium aluminum hydride

SLC38A2 ACTL8 NETO1 SLC38A4 ACTG2 PLCB2 TSHB F2 TG

5.46e-06320919CID000028112
Drugquinacrine

CRYGA ACTL8 ACTBL2 ACTG2 TSHB PLCL1 F2 ALOX5

5.95e-06243918CID000000237
DrugAC1OAGFB

VWF PLA2G4C ACTL8 PIK3C2B RAPGEF3 ACTBL2 ACTG2 PLCB2 TSHB F2 TG

1.01e-055399111CID006857345
DrugAC1L1KC5

CACNA1D ACTL8 RAPGEF3 NISCH ACTBL2 ACTG2 PLCB2 F2 ALOX5 RYR3 TG

1.05e-055419111CID000005428
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A

MET IKBKE MARF1 OCA2 HUWE1 ADARB1 EPHA1

1.25e-051939176981_UP
DrugAC1OAGKW

ACTL8 PIK3C2B SGK1 ACTG2 PLCB2 PLCL1 F2

1.25e-05193917CID006857413
DrugLMWH

MET MASP1 VWF AOC1 IGFBP4 ACTL8 NETO1 SGK1 ACTG2 KDR F2 RYR3

1.30e-056639112CID000000772
Drughistamine

VWF AOC1 IGFBP4 ACTL8 ACTBL2 TLR4 ACTG2 KDR PLCB2 TSHB ALOX5

1.44e-055609111CID000000774
Drug3,5-diiodo-L-thyronine

IGFBP4 SLC38A4 TSHB TG

1.59e-0538914CID000092859
DrugH2O2

MET AOC1 ACTL8 APEX2 PIK3C2B NETO1 PXDNL ACTBL2 ACTG2 KDR PLCB2 TGM6 F2 ALOX5 RYR3 TG

1.67e-0511839116CID000000784
DrugU46619

CACNA1D VWF ACTL8 ACTBL2 PLCB2 F2 ALOX5 RYR3

1.89e-05285918CID000005618
Drugguanosine 3',5'-cyclic monophosphoric acid

TRPM6 CACNA1D ACTL8 GUCY1A1 RAPGEF3 ACTG2 PLCB2 F2 ALOX5 RYR3 RING1

1.91e-055779111CID000000295
Drugplakin

ACTL8 ACTBL2 ACTG2 MACF1 F2

1.95e-0582915CID000018752
Drugsodium

TRPM6 SLC38A2 CACNA1D MET ACTL8 SGK1 SLC38A4 ACTBL2 ACTG2 PLCB2 HUWE1 F2 SLC38A3 RYR3

2.20e-059449114CID000000923
DrugD-myo-inositol 1,4-bisphosphate

ACTL8 ACTBL2 ACTG2 PLCB2 F2

2.46e-0586915CID000000805
Druglithium chromate

SLC38A2 ACTL8 NETO1 SLC38A4 ACTBL2 TSHB SLC38A3 TG

2.48e-05296918CID000026627
Drug(2S,3R)-Sphingosine

PLA2G4C ACTL8 PIK3C2B ACTBL2 ACTG2 PLCB2 TSHB F2 RYR3

2.58e-05389919CID000001104
Drugmethylhydrazine

MET RUNX1T1 HNF4A

2.71e-0515913CID000006061
Druggenistein

CACNA1D MET EFNB2 IGFBP4 ACTL8 PIK3C2B ACTBL2 ACTG2 KDR PLCB2 SMC5 F2 ALOX5 ZFPM2 RYR3

3.45e-0511179115CID005280961
Drug2BrP

MET RNASE1 VWF F2 HNF4A

3.60e-0593915CID006540269
Drugmanidipine

CACNA1D ACTL8 ACTBL2 ACTG2 RYR3

3.98e-0595915CID000004008
DrugAC1Q6LQU

ACTL8 ACTBL2 ACTG2 F2

4.06e-0548914CID000072380
DrugAC1L1K7T

MET VWF IGFBP4 PIK3C2B NETO1 KDR PLCB2 NUP214 BCAR3 RUNX1T1 ALOX5

4.37e-056329111CID000005376
DrugSch 40120

ALOX5 TG

4.73e-053912CID003081026
Drugforskolin from Coleus forskohlii

SLC38A2 CACNA1D IGFBP4 ACTL8 PIK3C2B RAPGEF3 SLC38A4 ACTBL2 ACTG2 PLCB2 TSHB F2 RYR3 TG

4.76e-0510139114CID000003413
DrugNsc687160

ACTL8 ACTBL2 ACTG2

4.83e-0518913CID005459290
Drugarabinosyladenine

CACNA1D RNASE1 VWF ACTL8 GUCY1A1 PIK3C2B RAPGEF3 ACTBL2 ACTG2 F2 ADARB1 RYR3

5.07e-057629112CID000000191
Drugenantio-PAF-C16

VWF ACTL8 ACTBL2 ACTG2 PLCB2 F2 ALOX5

5.61e-05244917CID000002499
Drugdithiotreitol

RNASE1 PLAAT1 VWF ACTL8 ACTBL2 ACTG2 PADI1 RYR3 TG

5.61e-05430919CID000019001
Drugtolytoxin

ACTL8 ACTBL2 ACTG2

5.71e-0519913CID006440827
Drugprostacyclin sodium salt

VWF ACTL8 NETO1 ACTG2 TSHB F2 ALOX5

6.54e-05250917CID000000159
DrugPTK/ZK

MET VWF ACTL8 ACTBL2

7.48e-0556914CID000151193
DrugNSC312786

ACTL8 ACTBL2 ACTG2

7.80e-0521913CID000329495
DrugAC1L8NVR

ACTL8 ACTBL2 ACTG2

7.80e-0521913CID000384633
DrugO-Ir

VWF EFNB2 IGFBP4 KDR

8.02e-0557914CID000448249
DrugD-myo-inositol-1,4,5-triphosphate

CACNA1D ACTL8 RAPGEF3 ACTBL2 ACTG2 PLCB2 TSHB PLCL1 F2 RYR3

9.06e-055689110CID000000806
DrugAGEPC

VWF ACTL8 NETO1 ACTBL2 ACTG2 PLCB2 F2 ALOX5

9.08e-05356918CID000461545
DrugNCGC 00229600

TSHB TG

9.43e-054912ctd:C556685
DrugRdv peptide

VWF F2

9.43e-054912CID000196843
DrugNSC-65828

RNASE1 AOC1

9.43e-054912CID005351857
Drugpotassium perchlorate

TSHB TG

9.43e-054912ctd:C009006
DrugICI 182,780; Down 200; 0.01uM; MCF7; HT_HG-U133A

ALKBH4 RNF123 IGFBP4 ACTL8 SGK1 LPCAT4

9.98e-051859165235_DN
Drugaluminum fluoride

MASP1 IGFBP4 ACTL8 ACTBL2 PLCB2 WDFY3 TG

1.01e-04268917CID000002124
DrugAC1L8UHC

TLR4 SMC5 TG

1.03e-0423913CID000432954
Drugblebbistatin

EFNB2 ACTL8 ACTBL2 ACTG2 EPHA1

1.03e-04116915CID003476986
Drugtriphosphoinositide

TRPM6 PLA2G4C ACTL8 ACTG2 DECR2 PLCB2 F2

1.13e-04273917CID009543520
Drugglutamate

TRPM6 APIP SLC38A2 CACNA1D ACTL8 SGK1 SLC38A4 ACTBL2 ACTG2 PLCB2 ADARB1 SLC38A3 RYR3

1.14e-049629113CID000000611
Drugresveratrol; Up 200; 50uM; MCF7; HG-U133A

MET PLA2G4C MARF1 DECR2 TSHB RUNX1T1

1.16e-04190916595_UP
Drugmethyl ethyl ketone

MET MASP1 VWF ACTL8 RAPGEF3 NISCH ACTG2 KDR F2 SLC38A3

1.19e-045879110CID000006569
DrugGTP[S]

CACNA1D MASP1 ACTL8 NISCH ACTBL2 ACTG2 PLCB2 F2 RYR3 TG

1.25e-045919110CID000001764
DrugRapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A

SGK1 TESK2 WDFY3 BCAR3 ZNF688 ALOX5

1.26e-041939161148_UP
DrugFortress

RNASE1 VWF F2

1.33e-0425913CID000091655
DrugAC1L1UD1

RNASE1 VWF F2

1.33e-0425913CID000035754
DrugPantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; MCF7; HT_HG-U133A

RNF123 IKBKE ACTG2 CHD3 LRRC14 ADARB1

1.37e-041969163248_DN
DrugHeliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A

CACNA1D ACTL8 CHD3 LRRC14 WDFY3 EPHA1

1.37e-041969164739_DN
Drugtetraethylenepentamine pentahydrochloride; Down 200; 100uM; HL60; HG-U133A

MASP1 PLCB2 NUP214 SMC5 PADI1 TG

1.37e-04196916412_DN
Drug(+,-)-Octopamine hydrochloride [770-05-8]; Up 200; 21uM; HL60; HT_HG-U133A

MASP1 PLA2G4C CTC1 ACTG2 HNF4A PPP4R4

1.41e-041979163112_UP
DrugMefexamide hydrochloride [3413-64-7]; Up 200; 12.6uM; MCF7; HT_HG-U133A

IKBKE LPCAT4 WDFY3 HUWE1 RUNX1T1 EPHA1

1.41e-041979167478_UP
DrugPerphenazine [58-39-9]; Down 200; 10uM; MCF7; HT_HG-U133A

MET IKBKE LPCAT4 ACTG2 LRRC14 WDFY3

1.41e-041979161540_DN
Drug5666823; Up 200; 100uM; MCF7; HG-U133A

MET TSHB HUWE1 HNF4A ZNF688 PADI1

1.41e-04197916609_UP
Drugvinblastine sulfate; Down 200; 0.1uM; MCF7; HT_HG-U133A

LPCAT4 OCA2 WDFY3 HNF4A ZNF688 PADI1

1.45e-041989167517_DN
DrugBenoxinate hydrochloride [5987-82-6]; Down 200; 11.6uM; HL60; HG-U133A

RNF123 PIK3C2B IKBKE DECR2 RUNX1T1 MTMR9

1.45e-041989161976_DN
Drugnitrendipine; Up 200; 10uM; MCF7; HG-U133A

MASP1 GUCY1A1 RAPGEF3 TSHB OCA2 PADI1

1.45e-04198916336_UP
DrugPepstatin A [26305-03-3]; Down 200; 5.8uM; MCF7; HT_HG-U133A

CACNA1D MET RNF123 ACTL8 ADARB1 EPHA1

1.45e-041989163264_DN
DrugLisinopril [83915-83-7]; Up 200; 9uM; MCF7; HT_HG-U133A

MET IKBKE ZNF749 TSHB EPB41L3 EPHA1

1.49e-041999165504_UP
DrugTrolox [53188-07-1]; Down 200; 16uM; MCF7; HT_HG-U133A

MET LPCAT4 UBA6 CHD3 ADARB1 MTMR9

1.49e-041999162883_DN
DrugHydrocortisone base [50-23-7]; Down 200; 11uM; MCF7; HT_HG-U133A

IPO7 TESK2 LRRC14 NUP214 ADARB1 MTMR9

1.53e-042009165284_DN
DrugCID365768

RUNX1T1 ALOX5

1.57e-045912CID000365768
DrugAP10

TSHB TG

1.57e-045912CID000193748
Drugmethenamine silver

ACTL8 IKBKE NETO1 ACTG2 BCAR3 RUNX1T1

1.57e-04201916CID000004101
DrugCalcium

TRPM6 CACNA1D AOC1 RAPGEF3 KDR F2 HNF4A ALOX5 RYR3

1.58e-04493919ctd:D002118
DrugAC1L9K72

PLAAT1 PLA2G4C NETO1 PLCB2 F2 SLC38A3 ALOX5

1.64e-04290917CID000446872
Drugbeta-tocopherol

NETO1 F2 ALOX5

1.69e-0427913CID000008989
DrugAC1L1ERT

ACTL8 ACTBL2 ACTG2 F2

1.69e-0469914CID000002920
DrugNSC613009

ACTL8 RAPGEF3 ACTBL2 ACTG2 RYR3

1.76e-04130915CID000003800
Drugpyrene

ACTL8 APEX2 ACTBL2 ACTG2 ACTR2

1.83e-04131915CID000031423
DrugBarium

TRPM6 CACNA1D SGK1 F2

2.00e-0472914ctd:D001464
Drugammonia

SLC38A2 AOC1 ACTL8 ACTBL2 ACTG2 OCA2 TGM6 ADARB1 PADI1

2.01e-04509919CID000000222
DrugPOPC

PLA2G4C PIK3C2B NETO1 PLCB2 F2 SLC38A3 ALOX5

2.28e-04306917CID000065167
Drugazaspiracid

ACTL8 ACTBL2 ACTG2

2.32e-0430913CID006451158
DrugPF-00356231

VWF OCA2 F2

2.32e-0430913CID000448942
DrugAC1Q6T8I

RNASE1 NISCH PLCB2

2.32e-0430913CID000000343
Drug[(2R,3R,4R,5R,6R)-2-[[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-[(2S,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

NETO1 ALOX5

2.35e-046912CID010395325
Drugipodate

TSHB TG

2.35e-046912CID000005241
Drug8-bromoguanosine 3',5'-cyclic monophosphate

CACNA1D ACTL8 GUCY1A1 PIK3C2B ACTG2 F2 RYR3

2.37e-04308917CID000001915
DrugSB203580

SLC38A2 MET VWF ACTL8 RAPGEF3 ACTBL2 TLR4 ACTG2 TGM6 F2 ALOX5

2.52e-047719111CID000176155
Drugalpha-(methylamino)isobutyric acid

SLC38A2 SLC38A4 SLC38A3

2.56e-0431913CID000075725
Drugmu-I

NETO1 TSHB RUNX1T1 TG

2.72e-0478914CID011987863
DrugAC1L1HS4

ACTL8 ACTBL2 ACTG2

2.82e-0432913CID000004267
DrugNSC226080

SLC38A2 MET ACTL8 PIK3C2B SGK1 SLC38A4 ACTBL2 KDR NUP214 F2 RYR3

2.84e-047829111CID000005040
DrugAC1L9EF8

ACTL8 ACTBL2 ACTG2 TGM6

2.85e-0479914CID000443315
DrugML-9

EFNB2 ACTL8 ACTBL2 ACTG2 F2

3.12e-04147915CID000004217
Drugtrifluoperazine

ACTL8 ACTBL2 ACTG2 TSHB NUP214 F2 ALOX5

3.23e-04324917CID000005566
Drugammonium perchlorate

TSHB TG

3.27e-047912ctd:C053506
DrugO630

TSHB TG

3.27e-047912CID006327651
Drugamino perchlorate

TSHB TG

3.27e-047912CID006327670
Diseaselarge cell carcinoma (is_implicated_in)

MET STRAP

2.75e-053902DOID:4552 (is_implicated_in)
Diseasesarcoma (is_marker_for)

MET KDR

9.15e-055902DOID:1115 (is_marker_for)
Diseaseliver cirrhosis (is_marker_for)

TLR4 KDR F2 HNF4A

1.18e-0482904DOID:5082 (is_marker_for)
DiseaseReperfusion Injury

EFNB2 TLR4 KDR ALOX5

1.62e-0489904C0035126
DiseaseLeukemia, Myelocytic, Acute

MET CTC1 SGK1 NUP214 RUNX1T1

1.92e-04173905C0023467
Diseasevenous thromboembolism, factor VII measurement

VWF F2 ZFPM2

2.14e-0438903EFO_0004286, EFO_0004619
DiseaseMoyamoya disease (implicated_via_orthology)

ACTBL2 ACTG2

2.55e-048902DOID:13099 (implicated_via_orthology)
Diseaseautosomal dominant nonsyndromic deafness 20 (implicated_via_orthology)

ACTBL2 ACTG2

2.55e-048902DOID:0110550 (implicated_via_orthology)
DiseaseBaraitser-Winter syndrome 1 (implicated_via_orthology)

ACTBL2 ACTG2

2.55e-048902DOID:0081112 (implicated_via_orthology)
Diseasethoracic aortic aneurysm (implicated_via_orthology)

ACTBL2 ACTG2

2.55e-048902DOID:14004 (implicated_via_orthology)
Diseasevenous thromboembolism, von Willebrand factor measurement

VWF F2 ZFPM2

2.89e-0442903EFO_0004286, EFO_0004629
Diseasehepatocellular carcinoma (is_marker_for)

MET TLR4 SMARCC1 KDR F2 HNF4A

3.26e-04301906DOID:684 (is_marker_for)
DiseaseThrombus

VWF GUCY1A1 F2

3.79e-0446903C0087086
Diseaseintestinal atresia (implicated_via_orthology)

ACTBL2 ACTG2

4.07e-0410902DOID:10486 (implicated_via_orthology)
Diseasepatent ductus arteriosus (implicated_via_orthology)

ACTBL2 ACTG2

4.07e-0410902DOID:13832 (implicated_via_orthology)
DiseaseAdenocarcinoma of lung (disorder)

TRPM6 SMARCC1 KDR PRKDC ALOX5

4.29e-04206905C0152013
DiseaseCarcinoma, Granular Cell

MET SMARCC1 KDR ALOX5

4.47e-04116904C0205644
DiseaseAdenocarcinoma, Tubular

MET SMARCC1 KDR ALOX5

4.47e-04116904C0205645
DiseaseAdenocarcinoma, Oxyphilic

MET SMARCC1 KDR ALOX5

4.47e-04116904C0205642
DiseaseCarcinoma, Cribriform

MET SMARCC1 KDR ALOX5

4.47e-04116904C0205643
DiseaseAdenocarcinoma, Basal Cell

MET SMARCC1 KDR ALOX5

4.47e-04116904C0205641
DiseaseAdenocarcinoma

MET SMARCC1 KDR ALOX5

4.47e-04116904C0001418
DiseaseThrombosis

VWF GUCY1A1 F2

4.57e-0449903C0040053
Diseaseserum albumin measurement

FAM117A AOC1 SLC38A4 SMARCC1 BEND3 MACF1 HNF4A PPP4R4

4.59e-04592908EFO_0004535
Diseasecognitive inhibition measurement

TRPM6 PXDNL TGM6

4.85e-0450903EFO_0007969
Diseaseobesity (implicated_via_orthology)

TLR4 PLCB2 F2 HNF4A ADARB1

5.21e-04215905DOID:9970 (implicated_via_orthology)
Diseasesystemic scleroderma (is_marker_for)

VWF KDR F2

5.76e-0453903DOID:418 (is_marker_for)
DiseaseAcute Myeloid Leukemia, M1

MET SGK1 NUP214 RUNX1T1

5.92e-04125904C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

MET SGK1 NUP214 RUNX1T1

5.92e-04125904C1879321
DiseaseN-acetylputrescine measurement

AOC1 SLC38A3

5.95e-0412902EFO_0800127
Diseaseasthma (is_marker_for)

TLR4 KDR F2 ALOX5

6.10e-04126904DOID:2841 (is_marker_for)
Diseasehyperglycemia (is_marker_for)

TSHB F2

7.02e-0413902DOID:4195 (is_marker_for)
DiseaseCongenital Hypothyroidism

TSHB TG

7.02e-0413902C0010308
Diseasetype 2 diabetes mellitus (is_marker_for)

CACNA1D TLR4 KDR F2

8.12e-04136904DOID:9352 (is_marker_for)
DiseaseDiabetic Neuralgia

SGK1 TLR4

8.17e-0414902C0751074
DiseaseDiabetic Neuropathies

SGK1 TLR4

8.17e-0414902C0011882
DiseaseAsymmetric Diabetic Proximal Motor Neuropathy

SGK1 TLR4

8.17e-0414902C0271674
DiseaseSymmetric Diabetic Proximal Motor Neuropathy

SGK1 TLR4

8.17e-0414902C0271673
DiseaseDiabetic Mononeuropathy

SGK1 TLR4

8.17e-0414902C0271678
DiseaseDiabetic Autonomic Neuropathy

SGK1 TLR4

8.17e-0414902C0271686
DiseaseDiabetic Amyotrophy

SGK1 TLR4

8.17e-0414902C0271685
DiseaseDiabetic Polyneuropathies

SGK1 TLR4

8.17e-0414902C0271680
DiseaseDiabetic Asymmetric Polyneuropathy

SGK1 TLR4

8.17e-0414902C0393835
Diseaseresponse to olanzapine

ANKS1B ZFPM2

9.41e-0415902GO_0097333
Diseasevenous thromboembolism, fibrinogen measurement

VWF HNF4A ZFPM2

1.14e-0367903EFO_0004286, EFO_0004623
Diseaseallergic rhinitis (is_marker_for)

TLR4 F2

1.21e-0317902DOID:4481 (is_marker_for)
DiseaseUremia

SGK1 KDR

1.21e-0317902C0041948
Diseaseunipolar depression, bipolar disorder

PXDNL TLR4 PLCL1 ZCCHC7

1.35e-03156904EFO_0003761, MONDO_0004985
DiseaseSchizophrenia

SLC38A2 MET EFNB2 PLA2G4C TLR4 KDR F2 ADARB1 ACTR2

1.50e-03883909C0036341
Diseaseresponse to methotrexate, neurotoxicity

MACF1 PLCL1

1.52e-0319902EFO_0011057, GO_0031427
Diseaseresponse to angiotensin-converting enzyme inhibitor

TESK2 ANKS1B TG

1.77e-0378903EFO_0005325
DiseaseDeep Vein Thrombosis

KDR F2

1.86e-0321902C0149871
DiseaseVenous Thrombosis

KDR F2

1.86e-0321902C0042487
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

VWF ZFPM2

1.86e-0321902EFO_0004286, EFO_0004792
Diseasecolorectal carcinoma (is_implicated_in)

EFNB2 STRAP

2.04e-0322902DOID:0080199 (is_implicated_in)
Diseasevenous thromboembolism, tissue plasminogen activator measurement

VWF ZFPM2

2.23e-0323902EFO_0004286, EFO_0004791
Diseasehepatocellular carcinoma (is_implicated_in)

MET TLR4 KDR RYR3

2.32e-03181904DOID:684 (is_implicated_in)
Diseaseliver fibrosis measurement

VWF BCAR3 ZFPM2

2.34e-0386903EFO_0010576
Diseasealanine measurement

SLC38A4 LRRC14 ALOX5

2.34e-0386903EFO_0009765
Diseasehousehold income

RNF123 PIK3C2B SMARCC1 LRRC14 PLCL1

2.42e-03304905EFO_0009695
Diseasetrans fatty acid measurement, trans/trans-18:2 fatty acid measurement

CACNA1D RYR3

2.43e-0324902EFO_0006821, EFO_0006826
Diseaseprostate specific antigen measurement

APIP TLR4 CHD3 PLCL1

2.66e-03188904EFO_0004624
DiseaseHypertensive disease

VWF AOC1 GUCY1A1 TLR4

2.77e-03190904C0020538
Diseasesmoking status measurement

CACNA1D MET PXDNL TLR4 ANKS1B SMARCC1 CHD3 PLCL1 RUNX1T1 ADARB1

2.81e-0311609010EFO_0006527
DiseaseBradycardia

CACNA1D NISCH

2.85e-0326902C0428977

Protein segments in the cluster

PeptideGeneStartEntry
LDYCPERGSAIDPHL

ALKBH4

156

Q9NXW9
LYHIPEFIPEARGLE

CATSPERG

446

Q6ZRH7
LVPVGRCHCEPGYEE

EPHA1

256

P21709
ETAECEFPPHLDVYI

CTC1

936

Q2NKJ3
TVPLRCLEEHYGTSP

BCAR3

256

O75815
QEYDEAGPPIVHRKC

ACTBL2

361

Q562R1
DICHPDTFSYPIERG

ACTL8

56

Q9H568
NHSYIFKREPPEGCE

FAM117A

331

Q9C073
PEYDEAGPSIVHRKC

ACTG2

361

P63267
CVPELFRLPEIYSLH

CRYGA

111

P11844
PRVYGVAPHCLDEGT

CENPVL1

216

A0A0U1RR11
YCPHADPGRPERLVF

APEX2

156

Q9UBZ4
ADDPVHYPRALCLFE

AOC1

406

P19801
ICPVYEGFSLPHLTR

ACTR2

166

P61160
GPEDGEIHPEICRLY

RGS7BP

111

Q6MZT1
QEKGSRCIPVYHPEF

OCA2

106

Q04671
RCIPVYHPEFITAEE

OCA2

111

Q04671
EVFEPPHYELCTLRG

NETO1

386

Q8TDF5
EPLGLHCIFIDDYLS

PADI1

621

Q9ULC6
HVPGPECRDLTSYAI

BEND3

661

Q5T5X7
CESPENPFHLYGKRE

ANKS1B

616

Q7Z6G8
CSIVDVEFLPVYHPS

LPCAT4

261

Q643R3
EFLHRPASGYVPEEI

RUNX1T1

431

Q06455
VLHRPFYPAVEGTLC

MTMR9

16

Q96QG7
PTEGLGECYHPRCDI

ZFPM2

776

Q8WW38
GECYHPRCDIFPGIV

ZFPM2

781

Q8WW38
EYLFEGHLCVLEPSV

IKBKE

351

Q14164
GNDYIVPRHCPELAE

HNF4A

246

P41235
IPLRTADSVFCPHYE

EFNB2

291

P52799
GDISPYTIPEEDRHC

IPO7

76

O95373
PDVEGDDCLPAYRHL

DECR2

6

Q9NUI1
CPPFYESDHPVRVLD

NUP214

231

P35658
CGDARIFSPHEPILE

ADARB1

451

P78563
GCFHLLDELPDTVYR

HUWE1

1446

Q7Z6Z7
HGIVDPENCRIVPYS

MACF1

2621

Q9UPN3
ECDLVYTFFHPLPRD

PIK3C2B

1466

O00750
DYCRRHKIPFPQVEE

PLA2G4C

426

Q9UP65
RDHGIPPYVDFRVFC

PXDNL

1146

A1KZ92
PRVYGVAPHCLDEGT

CENPVL2

216

P0DPI3
YHLVCLDPELDRAPE

CHD3

401

Q12873
PRVYGVAPHCLDEGT

CENPVL3

216

A0A0U1RRI6
CSPIIFEELEYHEPV

MARF1

961

Q9Y4F3
IFDIEDHPEVPCPYD

MASP1

231

P48740
PTICREDPEIHGYFR

CACNA1D

1821

Q01668
EDPEIHGYFRDPHCL

CACNA1D

1826

Q01668
DCKLPGYEPSRAEHL

EPB41L3

536

Q9Y2J2
FRPHPLLVEKGEYCQ

RING1

266

Q06587
EALLRPPFDACHAYV

OTOG

351

Q6ZRI0
CGAQDKEHPRYLIPE

APIP

16

Q96GX9
VAEYKTGPVLEHPDC

MET

81

P08581
AFVCHPEVLPIYTEL

SLC38A3

296

Q99624
HDPEVPVRYTIAICF

PPP4R4

406

Q6NUP7
ITLKTPHGDYIEFPC

ALOX5

86

P09917
ECHDLTGRFPDYPDA

IQCA1L

306

A6NCM1
TILCDPETLFYESPH

PPP1R35

206

Q8TAP8
TFCGTPEYLAPEVLH

SGK1

256

O00141
GRYCLEHLPAEFPSL

SH2D5

351

Q6ZV89
VGECIRTVPYTDPDH

PITRM1

866

Q5JRX3
RTHEDLYIIPIPNCD

IGFBP4

191

P22692
FAFVCHPEVLPIYSE

SLC38A4

341

Q969I6
ERHIIVACEGSPYVP

RNASE1

131

P07998
ECILHFLRLPIEDPY

SMARCC1

656

Q92922
ATPRPLHLGFLCEYD

PM20D2

101

Q8IYS1
GPIHCVRFSPDGELY

STRAP

266

Q9Y3F4
RTHPDEPLYSFCIGL

GTF3C3

761

Q9Y5Q9
YNSHRDPPEEEIPFC

UBA6

611

A0AVT1
IDPYVCIEIHGIPAD

PLCL1

746

Q15111
VGDKVPYDICRPDHS

RAPGEF3

556

O95398
RCPYEPHLAELDPTF

ZNF653

136

Q96CK0
IEHQEILSRPTPYEC

ZNF749

286

O43361
CLYLFFDLPHVPEAV

WDFY3

156

Q8IZQ1
DPPFHTAGRLIYCID

TRPM6

931

Q9BX84
DISEPPLHDFYCSRL

VWF

1261

P04275
YPDSVFGRLFDLCHP

SMC1B

511

Q8NDV3
FSFVCHPAVLPIYEE

SLC38A2

301

Q96QD8
CPCPEEIREELYDFH

RYR3

1886

Q15413
CYPHSLRAVERIPEE

RNF123

931

Q5XPI4
FLLDEDCVHYPLPEF

NISCH

1381

Q9Y2I1
PERYHCIEKGFVPLN

USP49

476

Q70CQ1
CPRPEIDEIFTSYHA

PLCB2

216

Q00722
CPGDLIEVFRPGYQH

PLAAT1

16

Q9HDD0
DFIYRTVEIPGCPLH

TSHB

76

P01222
PLPEYHVRIAGFDER

PRKDC

3711

P78527
PPVLFRHYPDIFEEC

ZNF688

261

P0C7X2
YVPRPTNHVGLFLDC

TRIM49D1

401

C9J1S8
HECPEREVYDPSPVS

ZCCHC7

361

Q8N3Z6
DYIHPVCLPDRETAA

F2

476

P00734
DLVYSIIDHIRPGPC

STARD4

61

Q96DR4
LPLDEHCERLPYDAS

KDR

811

P35968
FPHCEDYVASLGRPV

VWA3B

61

Q502W6
PEFLHQEACPFVGRE

TESK2

461

Q96S53
FLTYDICEVSPGPHL

SMC5

61

Q8IY18
LEEGVPPFQLCLHYR

TLR4

696

O00206
LDCGSPDIEVHTYPF

TG

2046

P01266
EVGLRYLPHEELFCS

ZNF45

91

Q02386
HTQEYPCPELVVRRG

TGM6

21

O95932
FPSEIPGICHFLDAY

GUCY1A1

646

Q02108
AELRTVVHPFPVDCY

LRRC14

421

Q15048