Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A6 SLC12A3 SLC12A4 SLC12A7	9.44e-07	9	189	4	GO:0015379
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC5A6 SLC12A6 SLC17A4 SLC6A2 SLC17A5 SLC12A3 SLC12A4 SLC2A13 SLC12A7	1.99e-06	119	189	9	GO:0015294
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC12A6 SLC6A2 SLC12A3 SLC12A4 SLC12A7	2.11e-06	23	189	5	GO:0015377
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC12A6 SLC6A2 SLC12A3 SLC12A4 SLC12A7	4.03e-06	26	189	5	GO:0015296
GeneOntologyMolecularFunction	symporter activity	SLC5A6 SLC12A6 SLC17A4 SLC6A2 SLC17A5 SLC12A3 SLC12A4 SLC2A13 SLC12A7	1.33e-05	150	189	9	GO:0015293
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	CLCA1 SLC5A6 VDAC2 SLC12A6 SLC6A2 SLC12A3 SLC12A4 LRRC8B SLC12A7	1.40e-05	151	189	9	GO:0008509
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	CLCA1 SLC5A6 SLC12A6 SLC17A4 ABCC6 SLC6A2 SLC12A3 SLC12A4 SLC12A7	3.76e-05	171	189	9	GO:0015103
GeneOntologyMolecularFunction	enzyme regulator activity	PABIR1 A2M ERCC5 MYCBP2 ARHGEF38 CD55 BIRC6 SERPINI2 FGD5 HERC2 PZP GCN1 AGAP4 PREX1 ARHGAP21 AGAP1 RICTOR RGS12 PREX2 VAC14 IGF1 SIPA1L1 MAP3K13 LTF AGAP9 AGAP7P AGAP6 ELP4	1.69e-04	1418	189	28	GO:0030234
GeneOntologyMolecularFunction	ammonium channel activity	SLC12A6 SLC12A4 SLC12A7	1.72e-04	12	189	3	GO:0008519
GeneOntologyMolecularFunction	enzyme activator activity	ERCC5 GCN1 AGAP4 PREX1 ARHGAP21 AGAP1 RICTOR RGS12 PREX2 VAC14 IGF1 SIPA1L1 MAP3K13 LTF AGAP9 AGAP7P AGAP6	1.74e-04	656	189	17	GO:0008047
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CLCA1 KCNH1 SLC5A6 PKD1 VDAC2 SLC12A6 CACNA1C SLC17A4 GRID2 GRIK1 SLC6A2 KCNV1 SLC17A5 SLC12A3 SLC12A4 P2RX2 LRRC8B SLC2A13 SLC12A7	1.97e-04	793	189	19	GO:0015075
GeneOntologyMolecularFunction	GTPase activator activity	AGAP4 PREX1 ARHGAP21 AGAP1 RGS12 PREX2 SIPA1L1 AGAP9 AGAP7P AGAP6	3.39e-04	279	189	10	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	MYCBP2 ARHGEF38 FGD5 HERC2 AGAP4 PREX1 ARHGAP21 AGAP1 RGS12 PREX2 SIPA1L1 AGAP9 AGAP7P AGAP6	3.50e-04	507	189	14	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	MYCBP2 ARHGEF38 FGD5 HERC2 AGAP4 PREX1 ARHGAP21 AGAP1 RGS12 PREX2 SIPA1L1 AGAP9 AGAP7P AGAP6	3.50e-04	507	189	14	GO:0030695
GeneOntologyMolecularFunction	channel activity	CLCA1 KCNH1 PKD1 GJA10 VDAC2 SLC12A6 CACNA1C GRID2 GRIK1 KCNV1 SLC12A4 P2RX2 LRRC8B SLC12A7	4.95e-04	525	189	14	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CLCA1 KCNH1 PKD1 GJA10 VDAC2 SLC12A6 CACNA1C GRID2 GRIK1 KCNV1 SLC12A4 P2RX2 LRRC8B SLC12A7	5.04e-04	526	189	14	GO:0022803
GeneOntologyMolecularFunction	transporter activity	C2CD2L CLCA1 KCNH1 SLC5A6 PKD1 GJA10 VDAC2 SLC12A6 CACNA1C SLC17A4 GRID2 GRIK1 ATP10A ABCC6 SLC6A2 KCNV1 SLC17A5 SLC12A3 SLC12A4 P2RX2 LRP2 DISP2 LRRC8B SLC2A13 SLC12A7	5.06e-04	1289	189	25	GO:0005215
GeneOntologyMolecularFunction	phospholipid binding	AMER1 C2CD2L KCNH1 AGAP4 PREX1 VDAC2 AGAP1 TECPR1 SGIP1 ZFYVE28 P2RX2 AGAP9 AGAP7P AGAP6	7.52e-04	548	189	14	GO:0005543
GeneOntologyMolecularFunction	protein serine/threonine kinase activator activity	GCN1 RICTOR IGF1 MAP3K13 LTF	8.70e-04	78	189	5	GO:0043539
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	KCNH1 SLC12A6 GRIK1 KCNV1 SLC12A3 SLC12A4 SLC12A7	1.08e-03	167	189	7	GO:0015079
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	CLCA1 SLC12A6 SLC6A2 SLC12A3 SLC12A4 SLC12A7	1.23e-03	125	189	6	GO:0015108
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNH1 SLC5A6 PKD1 SLC12A6 CACNA1C SLC17A4 GRIK1 SLC6A2 KCNV1 SLC12A3 SLC12A4 SLC12A7	1.64e-03	465	189	12	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	KCNH1 SLC5A6 PKD1 SLC12A6 CACNA1C SLC17A4 GRIK1 SLC6A2 KCNV1 SLC17A5 SLC12A3 SLC12A4 P2RX2 SLC2A13 SLC12A7	1.68e-03	664	189	15	GO:0008324
GeneOntologyMolecularFunction	transmembrane transporter activity	CLCA1 KCNH1 SLC5A6 PKD1 GJA10 VDAC2 SLC12A6 CACNA1C SLC17A4 GRID2 GRIK1 ABCC6 SLC6A2 KCNV1 SLC17A5 SLC12A3 SLC12A4 P2RX2 DISP2 LRRC8B SLC2A13 SLC12A7	1.84e-03	1180	189	22	GO:0022857
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC5A6 SLC12A6 SLC17A4 SLC6A2 SLC17A5 SLC12A3 SLC12A4 SLC2A13 SLC12A7	2.10e-03	296	189	9	GO:0015291
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC5A6 SLC12A6 SLC17A4 SLC6A2 SLC17A5 SLC12A3 SLC12A4 SLC2A13 SLC12A7	2.35e-03	301	189	9	GO:0022853
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CLCA1 KCNH1 SLC5A6 PKD1 SLC12A6 CACNA1C SLC17A4 GRIK1 ABCC6 SLC6A2 KCNV1 SLC17A5 SLC12A3 SLC12A4 SLC2A13 SLC12A7	2.35e-03	758	189	16	GO:0015318
GeneOntologyMolecularFunction	diacylglycerol O-acyltransferase activity	AWAT2 MOGAT2	2.40e-03	8	189	2	GO:0004144
GeneOntologyMolecularFunction	2-acylglycerol O-acyltransferase activity	AWAT2 MOGAT2	2.40e-03	8	189	2	GO:0003846
GeneOntologyBiologicalProcess	monoatomic anion transport	CLCA1 SLC5A6 VDAC2 SLC12A6 SLC17A4 ABCC6 SLC17A5 SLC12A3 SLC12A4 LRRC8B SLC12A7	1.21e-06	183	192	11	GO:0006820
GeneOntologyBiologicalProcess	ammonium import across plasma membrane	SLC12A6 SLC12A4 SLC12A7	3.15e-06	4	192	3	GO:0140157
GeneOntologyBiologicalProcess	monoatomic anion transmembrane transport	CLCA1 SLC5A6 VDAC2 SLC12A6 ABCC6 SLC12A3 SLC12A4 LRRC8B SLC12A7	1.37e-05	153	192	9	GO:0098656
GeneOntologyBiologicalProcess	organelle fission	SPIRE2 STRA8 MEIOB CUL7 USP44 NEUROG1 BRCA2 ANLN NFIX RAD51B CEP85 OBSL1 COX10 CEP192 FANCM IGF1 TMCC1	2.62e-05	571	192	17	GO:0048285
GeneOntologyBiologicalProcess	regulation of cell cycle process	PABIR1 STRA8 BARD1 CUL7 BIRC6 USP44 NEUROG1 BRCA2 ANLN PKD1 MBD4 DYNC1H1 CUL4B RAD51B CEP85 OBSL1 CEP192 KIF20A IGF1 SUSD2 SENP2	4.25e-05	845	192	21	GO:0010564
GeneOntologyBiologicalProcess	regulation of GTPase activity	MKKS FGD5 MAP4K4 AGAP4 PREX1 AGAP1 RICTOR PREX2 SIPA1L1 AGAP9 AGAP7P AGAP6	7.51e-05	335	192	12	GO:0043087
GeneOntologyBiologicalProcess	chloride ion homeostasis	SLC12A6 SLC12A3 SLC12A4 SLC12A7	7.90e-05	25	192	4	GO:0055064
GeneOntologyBiologicalProcess	Wnt receptor catabolic process	RNF43 ZNRF3	8.62e-05	2	192	2	GO:0038018
GeneOntologyBiologicalProcess	nuclear division	SPIRE2 STRA8 MEIOB CUL7 USP44 NEUROG1 BRCA2 ANLN NFIX RAD51B CEP85 OBSL1 CEP192 FANCM IGF1	9.47e-05	512	192	15	GO:0000280
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	NEDD4 CLCA1 KCNH1 SLC5A6 PKD1 VDAC2 SLC12A6 CACNA1C SLC17A4 GRID2 GRIK1 ATP10A ABCC6 CEMIP SLC6A2 KCNV1 SLC17A5 SLC12A3 SLC12A4 P2RX2 ISCU LRRC8B SLC12A7 NNT	1.14e-04	1115	192	24	GO:0034220
GeneOntologyBiologicalProcess	monoatomic anion homeostasis	SLC12A6 SLC12A3 SLC12A4 SLC12A7	1.25e-04	28	192	4	GO:0055081
GeneOntologyBiologicalProcess	regulation of mitotic cell cycle	PABIR1 BARD1 CUL7 USP44 NEUROG1 BRCA2 ANLN PKD1 MBD4 CUL4B RAD51B OBSL1 CEP192 GMNN IGF1 SENP2	1.46e-04	594	192	16	GO:0007346
GeneOntologyBiologicalProcess	monoatomic ion transport	NEDD4 CLCA1 KCNH1 SLC5A6 PKD1 VDAC2 SLC12A6 CACNA1C SLC17A4 GRID2 GRIK1 ATP10A ABCC6 CEMIP SLC6A2 KCNV1 SLC17A5 IGF1 SLC12A3 SLC12A4 P2RX2 ISCU LRP2 LRRC8B LTF SLC12A7 NNT	1.86e-04	1374	192	27	GO:0006811
GeneOntologyBiologicalProcess	ammonium transmembrane transport	SLC12A6 SLC12A4 SLC12A7	2.12e-04	13	192	3	GO:0072488
GeneOntologyBiologicalProcess	protein ubiquitination	AMER1 MYCBP2 RNF19B BARD1 CUL7 BIRC6 RNF43 NEDD4 USP44 ZNRF3 USP4 HERC2 CUL4B PHRF1 FANCM TRIM7 KLHL15 SENP2 WDSUB1	2.14e-04	811	192	19	GO:0016567
MousePheno	absent pinna reflex	MKKS AGAP4 AGAP1 LRBA AGAP9 AGAP7P SLC12A7 AGAP6	4.25e-06	89	147	8	MP:0006358
MousePheno	fused cornea and lens	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	4.35e-06	24	147	5	MP:0001307
MousePheno	abnormal pinna reflex	MKKS AGAP4 AGAP1 LRBA AGAP9 AGAP7P SLC12A7 AGAP6	1.09e-05	101	147	8	MP:0001485
MousePheno	abnormal lens development	ZNRF3 NHS AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	1.74e-05	78	147	7	MP:0005545
MousePheno	cornea opacity	RNF19B AWAT2 AGAP4 AGAP1 LMX1B VWA5A AGAP9 AGAP7P AGAP6	4.59e-05	159	147	9	MP:0001314
Domain	SLC12A_fam	SLC12A6 SLC12A3 SLC12A4 SLC12A7	3.26e-07	7	186	4	IPR004842
Domain	SLC12_C	SLC12A6 SLC12A3 SLC12A4 SLC12A7	6.46e-07	8	186	4	IPR018491
Domain	SLC12	SLC12A6 SLC12A3 SLC12A4 SLC12A7	6.46e-07	8	186	4	PF03522
Domain	KCL_cotranspt	SLC12A6 SLC12A4 SLC12A7	3.86e-06	4	186	3	IPR000076
Domain	ArfGap	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	9.08e-06	29	186	5	SM00105
Domain	ARFGAP	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	9.08e-06	29	186	5	PS50115
Domain	ArfGap	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	9.08e-06	29	186	5	PF01412
Domain	ArfGAP	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	9.08e-06	29	186	5	IPR001164
Domain	APC_su10/DOC_dom	MYCBP2 CUL7 HERC2	3.30e-05	7	186	3	IPR004939
Domain	DOC	MYCBP2 CUL7 HERC2	3.30e-05	7	186	3	PS51284
Domain	ANAPC10	MYCBP2 CUL7 HERC2	3.30e-05	7	186	3	PF03256
Domain	APC10	MYCBP2 CUL7 HERC2	3.30e-05	7	186	3	SM01337
Domain	AA-permease/SLC12A_dom	SLC12A6 SLC12A3 SLC12A4 SLC12A7	6.05e-05	22	186	4	IPR004841
Domain	AA_permease	SLC12A6 SLC12A3 SLC12A4 SLC12A7	6.05e-05	22	186	4	PF00324
Domain	KCC1	SLC12A6 SLC12A4	9.86e-05	2	186	2	IPR000622
Domain	PH	ANLN FGD5 AGAP4 PREX1 ARHGAP21 AGAP1 TECPR1 PREX2 AGAP9 AGAP7P AGAP6	1.12e-04	278	186	11	SM00233
Domain	PH_DOMAIN	ANLN FGD5 AGAP4 PREX1 ARHGAP21 AGAP1 TECPR1 PREX2 AGAP9 AGAP7P AGAP6	1.15e-04	279	186	11	PS50003
Domain	PH_domain	ANLN FGD5 AGAP4 PREX1 ARHGAP21 AGAP1 TECPR1 PREX2 AGAP9 AGAP7P AGAP6	1.19e-04	280	186	11	IPR001849
Domain	-	BRPF3 SPIRE2 MYCBP2 RNF19B BARD1 RNF43 USP44 TRIM66 ZNRF3 FGD5 PHRF1 TRIM7 ZFYVE28 WDSUB1	1.69e-04	449	186	14	3.30.40.10
Domain	Znf_RING/FYVE/PHD	BRPF3 SPIRE2 MYCBP2 RNF19B BARD1 RNF43 USP44 TRIM66 ZNRF3 FGD5 PHRF1 TRIM7 ZFYVE28 WDSUB1	2.12e-04	459	186	14	IPR013083
Domain	Cul7	CUL7 HERC2	2.94e-04	3	186	2	PF11515
Domain	TECPR	HERC2 TECPR1	2.94e-04	3	186	2	SM00706
Domain	CPH_domain	CUL7 HERC2	2.94e-04	3	186	2	IPR021097
Domain	Beta-propeller_rpt_TECPR	HERC2 TECPR1	2.94e-04	3	186	2	IPR006624
Domain	PH_dom-like	ANLN FGD5 AGAP4 PREX1 ARHGAP21 AGAP1 TECPR1 RGS12 PREX2 LRBA AGAP9 AGAP7P AGAP6	3.55e-04	426	186	13	IPR011993
Domain	-	IFT140 BIRC6 BRWD3 SEMA6D SEMA3B SEC13 KIF21A WDR87 SMU1 LRBA WDSUB1	5.26e-04	333	186	11	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	IFT140 BIRC6 BRWD3 SEMA6D SEMA3B SEC13 KIF21A WDR87 SMU1 LRBA WDSUB1	5.53e-04	335	186	11	IPR015943
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A6 SLC12A3 SLC12A4 SLC12A7	3.47e-07	7	143	4	M27339
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A6 SLC12A3 SLC12A4 SLC12A7	3.47e-07	7	143	4	MM15081
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SYNRG SPIRE2 PCNX3 MYCBP2 PRAG1 BIRC6 RNF43 C2CD2L ZGPAT ZNRF3 RRP12 BANP PKD1 HERC2 GCN1 PREX1 ARHGAP21 CRAMP1 DYNC1H1 LRFN1 KHNYN CEP192 POM121C C2CD2 TRIM7 VAC14 SLC12A4 LMX1B TTLL4 NINL DISP2 SENP2 LRBA PRRT4	6.18e-16	1105	195	34	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRO GPATCH8 RUSC2 NEDD4 C2CD2L SEMA6D RRP12 BOD1L1 ARHGAP21 DYNC1H1 KHNYN OBSL1 CEP192 SIPA1L1 MACF1 PPIP5K1 DISP2 SENP2 CIPC	2.14e-12	407	195	19	12693553
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	6.51e-10	9	195	5	12640130
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	1.30e-09	10	195	5	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	2.37e-09	11	195	5	15381706
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PABIR1 TET2 SYNRG SPIRE2 AMER1 MYCBP2 PRAG1 RUSC2 NEDD4 ANLN NHS BOD1L1 MAP4K4 ARHGAP21 PAK5 RICTOR CEP192 RGS12 SIPA1L1 ISCU MACF1 TMCC1	3.89e-09	861	195	22	36931259
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SMG1 MYCBP2 BIRC6 C2CD2L ZNRF3 GCN1 PREX1 CUL4B OBSL1 SIPA1L1 MACF1 SENP2	6.33e-09	225	195	12	12168954
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	6.53e-09	13	195	5	27713690
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TET2 SMG1 IFT140 BRPF3 MAP4K4 AGAP4 CRAMP1 AGAP1 KIF21A PHRF1 FNBP4 ZFYVE28 TTLL4 NINL AGAP9 AGAP7P AGAP6	9.38e-09	529	195	17	14621295
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	1.01e-08	14	195	5	22453919
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	PRAG1 MAP4K4 AGAP4 VDAC2 AGAP1 CEP85 SIPA1L1 SMU1 AGAP9 AGAP7P AGAP6	4.85e-08	218	195	11	33378226
Pubmed	Similar effects of all WNK3 variants on SLC12 cotransporters.	SLC12A6 SLC12A3 SLC12A4 SLC12A7	6.59e-08	8	195	4	21613606
Pubmed	Cation-chloride cotransporters and neuronal function.	SLC12A6 SLC12A3 SLC12A4 SLC12A7	1.18e-07	9	195	4	19323993
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	SMG1 BIRC6 NEDD4 ADRA1B HERC2 MAP4K4 ARHGAP21 RICTOR CEP192 TRAPPC8 C2CD2 RGS12 SLC12A4 CDK5RAP1 TMF1 MACF1 LRBA SLC12A7	1.48e-07	719	195	18	35337019
Pubmed	A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.	SLC12A6 SLC12A4 SLC12A7	1.74e-07	3	195	3	11551954
Pubmed	Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.	SLC12A6 SLC12A4 SLC12A7	1.74e-07	3	195	3	15262997
Pubmed	K-Cl cotransporter gene expression during human and murine erythroid differentiation.	SLC12A6 SLC12A4 SLC12A7	1.74e-07	3	195	3	21733850
Pubmed	IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.	SLC12A6 IGF1 SLC12A7	1.74e-07	3	195	3	17133354
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	ADAMTS9 BOD1L1 HEATR5B ZNF471 PREX1 ARHGAP21 CRAMP1 TECPR1 SENP2	2.26e-07	153	195	9	10718198
Pubmed	Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.	SLC12A6 SLC12A4 SLC12A7	6.91e-07	4	195	3	12637262
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TET2 IFT140 CUL7 RRP12 FNBP4 CEMIP SIPA1L1 MACF1	7.66e-07	130	195	8	12421765
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 MYCBP2 BRWD3 TRIM66 ADAMTS9 PKD1 HERC2 MBD4 MAP4K4 PREX1 ARHGAP21 DYNC1H1 AGAP1 CNTN4 CEP85 KIF21A OBSL1 GRIK1 SIPA1L1 LRP2 MACF1 CIPC LRBA	1.02e-06	1285	195	23	35914814
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	AMER1 MYCBP2 ARHGEF38 BARD1 ALX4 BRWD3 NFIX BANP SEMA3B BOD1L1 CRAMP1 AGAP1 RAD51B SLC12A6 CACNA1C FNBP4 GRIK1 CEP192 ATP10A C2CD2 IGF1 CDK5RAP1 MACF1 LRBA TMCC1	1.06e-06	1489	195	25	28611215
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	RNF43 NHS MAP4K4 GCN1 ARHGAP21 KHNYN POM121C MACF1 SENP2 LRBA	2.62e-06	263	195	10	34702444
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PRAG1 NEDD4 AGAP4 DYNC1H1 AGAP1 SIPA1L1 MACF1 AGAP9 AGAP7P AGAP6	4.71e-06	281	195	10	28706196
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CUL7 BIRC6 TRIM66 ADAMTS9 PREX1 CNTN4 RICTOR TRAPPC8 FANCM POM121C ATP10A MACF1 TMCC1	4.84e-06	493	195	13	15368895
Pubmed	P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.	PREX1 RICTOR PREX2	5.98e-06	7	195	3	17565979
Pubmed	Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.	MYCBP2 HERC2 RGS12	5.98e-06	7	195	3	36700049
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	SLC12A6 SLC12A3 SLC12A4 SLC12A7	6.48e-06	22	195	4	18391953
Pubmed	Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.	SLC12A6 SLC12A4 SLC12A7	9.52e-06	8	195	3	11395011
Pubmed	The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.	SLC12A6 SLC12A4 SLC12A7	9.52e-06	8	195	3	24393035
Pubmed	Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).	SLC12A6 SLC12A4 SLC12A7	9.52e-06	8	195	3	12386165
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	CWF19L2 BRCA2 DYNC1H1 CACNA1C CAMK1D TLR5 CDK5RAP1 PAX7	1.44e-05	193	195	8	20677014
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SYNRG MYCBP2 ANLN BOD1L1 MAP4K4 GCN1 DYNC1H1 VDAC2 CEP85 FNBP4 SMU1 LRBA ELP4	1.52e-05	549	195	13	38280479
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYCBP2 CUL7 BIRC6 RRP12 HERC2 GCN1 DYNC1H1 SEC13 CUL4B PHRF1 SMU1 MACF1 LTF NNT	2.14e-05	653	195	14	22586326
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	MYCBP2 PRAG1 ARHGAP21 RICTOR SIPA1L1 ISCU	2.48e-05	102	195	6	15778465
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	BRPF3 WWC3 BIRC6 PAK5 CEMIP MACF1	2.62e-05	103	195	6	10574462
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	RUSC2 TRIM66 HERC2 DYNC1H1 KHNYN PPIP5K1	2.77e-05	104	195	6	9205841
Pubmed	RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.	RNF43 ZNRF3	3.13e-05	2	195	2	27661107
Pubmed	Mapping of TLR5 and TLR7 in central and distal human airways and identification of reduced TLR expression in severe asthma.	TLR7 TLR5	3.13e-05	2	195	2	24447081
Pubmed	Natural history of facial and skeletal features from neonatal period to adulthood in a 3M syndrome cohort with biallelic CUL7 or OBSL1 variants.	CUL7 OBSL1	3.13e-05	2	195	2	34597859
Pubmed	Identification and characterization of TMEM24 family genes in silico.	C2CD2L C2CD2	3.13e-05	2	195	2	15289880
Pubmed	Comprehensive comparison between 222 CTLA-4 haploinsufficiency and 212 LRBA deficiency patients: a systematic review.	CTLA4 LRBA	3.13e-05	2	195	2	33788257
Pubmed	Pediatric-onset Evans syndrome: Heterogeneous presentation and high frequency of monogenic disorders including LRBA and CTLA4 mutations.	CTLA4 LRBA	3.13e-05	2	195	2	29330115
Pubmed	ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.	RNF43 ZNRF3	3.13e-05	2	195	2	34129813
Pubmed	Further expanding the mutational spectrum and investigation of genotype-phenotype correlation in 3M syndrome.	CUL7 OBSL1	3.13e-05	2	195	2	30980518
Pubmed	Evaluation of Expression of LRBA and CTLA-4 Proteins in Common Variable Immunodeficiency Patients.	CTLA4 LRBA	3.13e-05	2	195	2	33191838
Pubmed	Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.	SLC12A6 SLC12A4	3.13e-05	2	195	2	31835175
Pubmed	Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice.	RICTOR SLC6A2	3.13e-05	2	195	2	20543991
Pubmed	P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.	PREX1 PREX2	3.13e-05	2	195	2	18334636
Pubmed	E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors.	RNF43 ZNRF3	3.13e-05	2	195	2	38969364
Pubmed	14-3-3 proteins regulate cullin 7-mediated Eag1 degradation.	CUL7 KCNH1	3.13e-05	2	195	2	36717938
Pubmed	Hyperproliferation of PKD1 cystic cells is induced by insulin-like growth factor-1 activation of the Ras/Raf signalling system.	PKD1 IGF1	3.13e-05	2	195	2	17396115
Pubmed	The Prognostic Value of Toll-Like Receptors in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.	TLR7 TLR5	3.13e-05	2	195	2	33008143
Pubmed	P-Rex1 and P-Rex2 RacGEFs and cancer.	PREX1 PREX2	3.13e-05	2	195	2	28710285
Pubmed	Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability.	PKD1 CACNA1C	3.13e-05	2	195	2	25888683
Pubmed	A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts.	C2CD2L C2CD2	3.13e-05	2	195	2	39158698
Pubmed	Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients.	TLR7 TLR5	3.13e-05	2	195	2	28856441
Pubmed	Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.	SLC12A6 SLC12A7	3.13e-05	2	195	2	10347194
Pubmed	Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations.	CUL7 CUL4B	3.13e-05	2	195	2	20005570
Pubmed	Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels.	NEDD4 CACNA1C	3.13e-05	2	195	2	21220429
Pubmed	Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.	SLC12A6 SLC12A4	3.13e-05	2	195	2	34031912
Pubmed	AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.	CTLA4 LRBA	3.13e-05	2	195	2	26206937
Pubmed	A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD.	ADRA1B SLC6A2	3.13e-05	2	195	2	23052569
Pubmed	A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.	A2M PZP	3.13e-05	2	195	2	1692292
Pubmed	Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.	PREX1 PREX2	3.13e-05	2	195	2	20694145
Pubmed	SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.	SLC12A6 SLC12A7	3.13e-05	2	195	2	31393094
Pubmed	The BARD1 Cys557Ser variant and breast cancer risk in Iceland.	BARD1 BRCA2	3.13e-05	2	195	2	16768547
Pubmed	Molecular cloning of two partial serotonin 5-HT1D receptor sequences in mouse and one in guinea pig.	HTR1D PAX7	3.13e-05	2	195	2	1521164
Pubmed	How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes.	PKD1 ABCC6	3.13e-05	2	195	2	18791038
Pubmed	Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth.	PECAM1 COX10	3.13e-05	2	195	2	32694534
Pubmed	Comparing the levels of CTLA-4-dependent biological defects in patients with LRBA deficiency and CTLA-4 insufficiency.	CTLA4 LRBA	3.13e-05	2	195	2	35491430
Pubmed	ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma.	BANP ZNF471	3.13e-05	2	195	2	38169650
Pubmed	Differential binding properties of human pregnancy zone protein- and alpha2-macroglobulin-proteinase complexes to low-density lipoprotein receptor-related protein.	A2M PZP	3.13e-05	2	195	2	11811950
Pubmed	Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.	KRT14 RICTOR	3.13e-05	2	195	2	28211872
Pubmed	Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.	CTLA4 LRBA	3.13e-05	2	195	2	28159733
Pubmed	Pulmonary manifestations of immune dysregulation in CTLA-4 haploinsufficiency and LRBA deficiency.	CTLA4 LRBA	3.13e-05	2	195	2	33710794
Pubmed	Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.	SLC12A6 SLC12A4	3.13e-05	2	195	2	17510708
Pubmed	RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.	RNF43 ZNRF3	3.13e-05	2	195	2	35039505
Pubmed	Toll-like receptor 5 and 7 expression in adenoid cystic carcinoma of major salivary glands.	TLR7 TLR5	3.13e-05	2	195	2	26888781
Pubmed	CTLA-4 Expression in CD4+ T Cells From Patients With LRBA Deficiency and Common Variable Immunodeficiency With No Known Monogenic Disease.	CTLA4 LRBA	3.13e-05	2	195	2	30530390
Pubmed	Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus.	TLR7 TLR5	3.13e-05	2	195	2	19473567
Pubmed	Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation.	CTLA4 LRBA	3.13e-05	2	195	2	28601686
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	HERC2 AGAP4 ARHGAP21 AGAP1 SGIP1 SIPA1L1 MACF1 MAP3K13 AGAP9 AGAP7P AGAP6	3.47e-05	430	195	11	32581705
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PCNX3 CD55 GPATCH8 C2CD2L ZGPAT ANLN SLC5A6 RRP12 HERC2 HEATR5B MBD4 PREX1 VDAC2 AGAP1 SEC13 PHRF1 RICTOR SIPA1L1 SMU1 TMF1 MACF1 TMCC1	3.83e-05	1497	195	22	31527615
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AMER1 ERCC5 CD55 GPATCH8 ANLN KCNH1 BOD1L1 ARHGAP21 KRT84 RICTOR CEP192 GLB1L2 SLC6A2 SIPA1L1 TTLL4 LRP2 MACF1 CIPC	4.35e-05	1084	195	18	11544199
Pubmed	Reconstructing human brown fat developmental trajectory in vitro.	PECAM1 KRT14 PAX7	4.76e-05	13	195	3	37647896
Pubmed	A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.	CNTN4 HTR1D LRP2	4.76e-05	13	195	3	21079607
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TET2 NEDD4 MAP4K4 AGAP4 AGAP1 CEP85 FNBP4 SIPA1L1 TTLL4 AGAP9 AGAP7P AGAP6	5.56e-05	536	195	12	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TET2 NEDD4 MAP4K4 AGAP4 AGAP1 CEP85 FNBP4 SIPA1L1 TTLL4 AGAP9 AGAP7P AGAP6	5.76e-05	538	195	12	10512203
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	IFT140 BRPF3 CUL7 RNF43 BRWD3 C2CD2L TRIM66 ZNRF3 CUL4B PHRF1 OBSL1 RICTOR POM121C KIF20A SIPA1L1 LRP2 MACF1 LRRC8B	6.30e-05	1116	195	18	31753913
Pubmed	A protein interaction landscape of breast cancer.	BARD1 GPATCH8 CUL7 BRCA2 MBD4 ARHGAP21 CUL4B RAD51B IGHA1 SMU1 MACF1 LTF NNT	6.65e-05	634	195	13	34591612
Pubmed	ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.	STRA8 RNF43 ZNRF3	7.51e-05	15	195	3	29735715
Pubmed	Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia.	ALX4 LMX1B PAX7	9.21e-05	16	195	3	35127681
Pubmed	Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.	NEDD4 SLC12A3	9.35e-05	3	195	2	21852580
Pubmed	Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.	BRCA2 IGF1	9.35e-05	3	195	2	18045956
Pubmed	Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion.	IGF1 SLC12A7	9.35e-05	3	195	2	19887603
Pubmed	Nedd4 controls animal growth by regulating IGF-1 signaling.	NEDD4 IGF1	9.35e-05	3	195	2	18812566
Pubmed	Frequent incidence of BARD1-truncating mutations in germline DNA from triple-negative breast cancer patients.	BARD1 BRCA2	9.35e-05	3	195	2	26010302
Pubmed	Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma.	IGF1 SLC12A7	9.35e-05	3	195	2	31034883
Interaction	TOP3B interactions	SYNRG SPIRE2 PCNX3 MYCBP2 PRAG1 BIRC6 RNF43 C2CD2L ZGPAT ZNRF3 RRP12 BANP PKD1 HERC2 GCN1 PREX1 ARHGAP21 CRAMP1 DYNC1H1 VDAC2 LRFN1 KHNYN CEP192 POM121C C2CD2 TRIM7 VAC14 SLC12A4 LMX1B TTLL4 NINL DISP2 SENP2 LRBA PRRT4	3.18e-07	1470	190	35	int:TOP3B
Interaction	KRT8 interactions	SMG1 KRT26 BIRC6 ANLN PKD1 USP4 FGD5 ARHGAP21 KRT14 CEP85 KRT84 OBSL1 RICTOR CEP192 ADAM12 SIPA1L1 NINL	1.02e-06	441	190	17	int:KRT8
Interaction	YWHAG interactions	PABIR1 TET2 SYNRG SPIRE2 AMER1 MYCBP2 CUL7 PRAG1 RUSC2 NEDD4 C2CD2L ANLN NHS BOD1L1 MAP4K4 ARHGAP21 DYNC1H1 AGAP1 PAK5 RICTOR CEP192 RGS12 SIPA1L1 ISCU NINL MACF1 PPIP5K1 LRBA TMCC1	6.09e-06	1248	190	29	int:YWHAG
Interaction	SFN interactions	PABIR1 TET2 SYNRG SPIRE2 MYCBP2 RUSC2 ANLN BANP NHS USP4 MAP4K4 ARHGAP21 RICTOR CEP192 RGS12 SIPA1L1 ISCU NINL MACF1 TMCC1	9.15e-06	692	190	20	int:SFN
Interaction	YWHAH interactions	PABIR1 TET2 SYNRG SPIRE2 AMER1 MYCBP2 PRAG1 RUSC2 NEDD4 ANLN NHS USP4 BOD1L1 MAP4K4 ARHGAP21 AGAP1 PAK5 RICTOR CEP192 RGS12 SIPA1L1 ISCU NINL MACF1 LRBA TMCC1	1.50e-05	1102	190	26	int:YWHAH
Interaction	SWSAP1 interactions	A2M CUL7 BANP RAD51B PPIP5K1	1.57e-05	34	190	5	int:SWSAP1
Interaction	FER1L4 interactions	ANLN CEMIP KIF20A	1.62e-05	6	190	3	int:FER1L4
Interaction	FN3KRP interactions	MAP4K4 CUL4B KIF20A IGHA1 SMU1 LTF	1.75e-05	58	190	6	int:FN3KRP
Interaction	MACF1 interactions	MYCBP2 CUL7 RNF43 BRWD3 ANLN FGD5 HERC2 OBSL1 KIF20A MACF1 LRBA	2.37e-05	247	190	11	int:MACF1
Interaction	KIFC3 interactions	KRT26 CWF19L2 BARD1 NEDD4 ZGPAT ANLN NHS HERC2 KRT14 FANCM KIF20A	2.85e-05	252	190	11	int:KIFC3
Interaction	LZTS2 interactions	CWF19L2 BRPF3 BIRC6 RNF43 TRIM66 ZGPAT BRCA2 ANLN AGAP1 CEP85 PAK5 CEP192 SIPA1L1 TTLL4 KLHL15 NINL	2.96e-05	512	190	16	int:LZTS2
Interaction	YWHAB interactions	PABIR1 TET2 SYNRG SPIRE2 MYCBP2 CUL7 RNF43 RUSC2 NEDD4 ANLN NHS USP4 ARHGAP21 DYNC1H1 AGAP1 PAK5 RICTOR CEP192 TRAPPC8 RGS12 SIPA1L1 NINL MACF1 TMCC1	3.12e-05	1014	190	24	int:YWHAB
Interaction	GIGYF1 interactions	BRPF3 RNF43 TRIM66 ANLN AGAP1 LRFN1 CEP85 SIPA1L1 NINL	4.77e-05	177	190	9	int:GIGYF1
Interaction	YWHAQ interactions	PABIR1 TET2 SYNRG SPIRE2 MYCBP2 CUL7 RNF43 RUSC2 NEDD4 ANLN NHS FGD5 GCN1 ARHGAP21 DYNC1H1 AGAP1 PAK5 OBSL1 RICTOR CEP192 RGS12 SIPA1L1 MACF1 LRBA TMCC1	5.35e-05	1118	190	25	int:YWHAQ
Interaction	FAM83H interactions	TRIM66 ANLN BOD1L1 HERC2 SEC13 KIF20A NINL FAM199X	5.86e-05	141	190	8	int:FAM83H
Interaction	PLEC interactions	TET2 CUL7 BRCA2 ANLN USP4 FGD5 HERC2 KRT14 PAK5 OBSL1 RICTOR FANCM KIF20A MACF1	6.10e-05	430	190	14	int:PLEC
Interaction	PHLDB2 interactions	BRPF3 CUL7 ANLN AGAP1 LRFN1 OBSL1 KIF20A SIPA1L1	6.47e-05	143	190	8	int:PHLDB2
Interaction	KRT6C interactions	KRT26 CUL7 KRT14 KRT84 RICTOR TRIM7	8.20e-05	76	190	6	int:KRT6C
Interaction	PRPF19 interactions	CWF19L2 ERCC5 CUL7 ANLN USP4 GCN1 DYNC1H1 SEC13 PHRF1 FNBP4 OBSL1 CEP192 KIF20A NINL	9.88e-05	450	190	14	int:PRPF19
Interaction	YWHAZ interactions	PABIR1 TET2 SYNRG SPIRE2 MYCBP2 BARD1 CUL7 RUSC2 NEDD4 ANLN NHS HERC2 ARHGAP21 DYNC1H1 VDAC2 AGAP1 PAK5 OBSL1 RICTOR CEP192 RGS12 TRIM7 SIPA1L1 ISCU LPIN2 MACF1 TMCC1	1.17e-04	1319	190	27	int:YWHAZ
Interaction	DES interactions	CWF19L2 RTN1 ANLN PKD1 KRT14 KRT84 TRIM7 KIF20A	1.30e-04	158	190	8	int:DES
Interaction	YWHAE interactions	PABIR1 TET2 SYNRG SPIRE2 MYCBP2 CUL7 PRAG1 RNF43 RUSC2 NEDD4 ANLN NHS FGD5 ARHGAP21 DYNC1H1 AGAP1 PAK5 OBSL1 RICTOR RGS12 SIPA1L1 ISCU LPIN2 MACF1 LRBA TMCC1	1.32e-04	1256	190	26	int:YWHAE
GeneFamily	ArfGAPs	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	4.99e-06	33	139	5	395
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP1 AGAP9 AGAP6	7.37e-06	17	139	4	1291
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ANLN FGD5 AGAP4 PREX1 ARHGAP21 AGAP1 AGAP9 AGAP7P AGAP6	3.10e-05	206	139	9	682
GeneFamily	WD repeat domain containing	IFT140 BRWD3 SEC13 KIF21A WDR87 SMU1 LRBA WDSUB1	9.61e-04	262	139	8	362
GeneFamily	Diacylglycerol O-acyltransferase 2 family	AWAT2 MOGAT2	1.59e-03	8	139	2	1235
GeneFamily	Cullins	CUL7 CUL4B	1.59e-03	8	139	2	1032
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF38 FGD5 PREX1 PREX2	1.67e-03	66	139	4	722
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	A2M PZP	2.04e-03	9	139	2	1234
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP8 SP9	2.04e-03	9	139	2	755
GeneFamily	CD molecules\|Toll like receptors	TLR7 TLR5	2.54e-03	10	139	2	948
GeneFamily	Solute carriers	SLC5A6 SLC12A6 SLC17A4 SLC6A2 SLC17A5 SLC12A3 SLC12A4 SLC2A13 SLC12A7	3.51e-03	395	139	9	752
Coexpression	GSE16385_UNTREATED_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN	MKKS CWF19L2 MYCBP2 GPR135 ADAMTS9 GMNN PREX2 P2RX2 TLR5 CIPC ELP4	3.00e-07	200	193	11	M7913
Coexpression	THEODOROU_MAMMARY_TUMORIGENESIS	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	7.40e-06	37	193	5	MM1121
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	TET2 SMG1 BARD1 BIRC6 MAP4K4 CAMK1D SIPA1L1 TTLL4 MACF1	7.98e-06	180	193	9	M8239
Coexpression	GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_6H_ACT_CD4_TCELL_DN	NEDD4 ZNRF3 C4BPA KRT84 ATP10A CEMIP KLHL15 TLR5 MAP3K13	1.58e-05	196	193	9	M4218
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	1.77e-05	44	193	5	MM485
Coexpression	GSE21670_UNTREATED_VS_TGFB_TREATED_STAT3_KO_CD4_TCELL_UP	IFT140 SPIRE2 AMER1 RUSC2 CEP85 RICTOR C2CD2 RGS12 TMCC1	1.78e-05	199	193	9	M7474
Coexpression	BILD_CTNNB1_ONCOGENIC_SIGNATURE	SMG1 BOD1L1 DYNC1H1 KHNYN LRBA TMCC1	2.62e-05	79	193	6	M7102
Coexpression	GSE7509_UNSTIM_VS_FCGRIIB_STIM_MONOCYTE_DN	TET2 IFT140 BRPF3 BRWD3 BOD1L1 SGIP1 TTLL4 MACF1	3.34e-05	166	193	8	M6826
Coexpression	GSE7568_CTRL_VS_3H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_DN	PABIR1 PKD1 USP4 TECPR1 RICTOR C2CD2 MACF1 WDSUB1	3.49e-05	167	193	8	M361
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT26 CFAP65 GPC5 SGIP1 GRID2 ABCC6 CEMIP SLC6A2 KCNV1	9.96e-09	137	195	9	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT26 CFAP65 GPC5 SGIP1 GRID2 ABCC6 CEMIP SLC6A2 KCNV1	9.96e-09	137	195	9	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1B NHS FGD5 GRIK1 RGS12 PREX2 IGF1 NINL PRRT4	1.34e-07	185	195	9	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B NHS FGD5 GRIK1 RGS12 PREX2 IGF1 NINL	1.83e-07	192	195	9	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SP8 ADRA1B NHS GRIK1 IGF1 SP9 SLC2A13 PRRT4	8.29e-07	169	195	8	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B NHS FGD5 GRIK1 RGS12 PREX2 IGF1	1.17e-06	177	195	8	fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1B NHS FGD5 GRIK1 RGS12 PREX2 IGF1 PRRT4	1.28e-06	179	195	8	97ba67a856680f24846244c0b92c886cc0e79537
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1B NHS FGD5 GRIK1 RGS12 PREX2 IGF1 NINL	1.45e-06	182	195	8	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 SEMA6D FGD5 VWA5B1 GRID2 RGS12 SLC6A2 IGF1	1.45e-06	182	195	8	724c33ad2fb525cbcfa5efa3362675eb42a5636d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B NHS FGD5 RGS12 PREX2 IGF1 NINL	1.45e-06	182	195	8	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1B ADAMTS9 NHS GRIK1 RGS12 PREX2 IGF1 NINL	1.51e-06	183	195	8	5e361be3ae3fe05098968e58427630127bd12675
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1B NHS GRIK1 RGS12 PREX2 IGF1 NINL PRRT4	1.51e-06	183	195	8	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	STRA8 ARHGEF38 SEMA6D NHS GPC5 SGIP1 NINL LRBA	1.57e-06	184	195	8	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1B NHS FGD5 GRIK1 RGS12 PREX2 IGF1 NINL	1.64e-06	185	195	8	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	ARHGEF38 USP44 ADRA1B GPC5 AGAP1 CNTN4 MAP3K13 LRBA	1.77e-06	187	195	8	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NHS AGAP1 CNTN4 KIF21A SLC17A4 ABCC6 LRP2 MAP3K13	1.77e-06	187	195	8	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1B SEMA6D NHS GRIK1 RGS12 PREX2 IGF1 NINL	1.77e-06	187	195	8	02105c82a9ba79d2f19e002188377fc3440770c2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NHS AGAP1 CNTN4 KIF21A SLC17A4 ABCC6 LRP2 MAP3K13	2.00e-06	190	195	8	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PECAM1 BRWD3 CD163 ADAM12 C2CD2 SLC17A5 IGF1 TLR5	2.00e-06	190	195	8	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B NHS FGD5 RGS12 PREX2 IGF1 SLC12A7	2.16e-06	192	195	8	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Serpinf1-Serpinf1_Aqp5_Vip\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ARID5A IGSF10 SP8 CNTN4 GLB1L2 IGF1 SP9	2.35e-06	136	195	7	8f5682422ba0b477c1e0700212948457f106cb10
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	BARD1 SP8 ADRA1B GLB1L2 RGS12 IGF1 SLC2A13	2.72e-06	139	195	7	408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	MYCBP2 RTN1 KCNH1 PKD1 CACNA1C CNTN4 PAK5 SLC2A13	2.92e-06	200	195	8	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NEDD4 ZGPAT NFIX TRIM7 IGF1 TTLL4 LTF	3.76e-06	146	195	7	1bf67a9416f52198931b912a31be4bab09fefd19
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADRA1B GRIK1 ADAM12 RGS12 IGF1 SLC2A13 KRTAP11-1	4.30e-06	149	195	7	10ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SP8 ADRA1B NHS GLB1L2 RGS12 IGF1 SP9	5.58e-06	155	195	7	105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-7\|TCGA-Liver / Sample_Type by Project: Shred V9	AMER1 RNF43 ZNRF3 NFIX SLC5A6 SLC6A2 TMCC1	6.60e-06	159	195	7	70288df54adab167c0f50675128619299077db11
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BARD1 SP8 ADRA1B CNTN4 RGS12 IGF1 SP9	1.06e-05	171	195	7	f9ae7964a3740f559431125c17c660549798cccc
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 FGD5 VWA5B1 GRID2 RGS12 SLC6A2 IGF1	1.10e-05	172	195	7	8b396d1e9173da104d467e42286379fe07cee257
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PECAM1 NEDD4 FGD5 PREX1 CAMK1D PREX2 PAX7	1.14e-05	173	195	7	afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCell	severe_influenza-Plasmablast\|World / disease group, cell group and cell class (v2)	ANLN IGKV1D-8 IGKV1-8 KIF20A IGF1 IGHA1 LTF	1.23e-05	175	195	7	e6d6c44510d5dc4eb0bae820125e42366f7a4e74
ToppCell	Influenza_Severe-Plasmablast\|World / Disease group and Cell class	ANLN IGKV1D-8 IGKV1-8 KIF20A IGF1 IGHA1 LTF	1.23e-05	175	195	7	14df8fc6f6beae1be7b7bd5837546d1ac1239a6f
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPIRE2 ARHGEF38 ADRA1B GPC5 CNTN4 ABCC6 LRBA	1.43e-05	179	195	7	815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CD163 ZGPAT NHS HEATR5B GRID2 CEMIP TLR5	1.43e-05	179	195	7	87f608b137aae34572b150492a83a3a127cff40b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BARD1 SP8 SEMA6D FGD5 RGS12 SLC6A2 IGF1	1.48e-05	180	195	7	c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1B NHS GRIK1 RGS12 PREX2 IGF1 PRRT4	1.53e-05	181	195	7	2f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	ARHGEF38 CD55 GPC5 AGAP1 RAD51B CNTN4 CAMK1D	1.53e-05	181	195	7	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADRA1B SLC5A6 NHS GRIK1 IGF1 SP9 SLC2A13	1.59e-05	182	195	7	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGEF38 USP44 ADRA1B GPC5 AGAP1 CNTN4 MAP3K13	1.77e-05	185	195	7	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B NHS FGD5 RGS12 PREX2 IGF1	1.77e-05	185	195	7	4c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B SEMA6D FGD5 RGS12 SLC6A2 IGF1	1.77e-05	185	195	7	3189e91fe26df59bd605d2b6223ceb1779daf0b8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B NHS FGD5 GRIK1 RGS12 IGF1	1.77e-05	185	195	7	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M ARID5A SGIP1 CAMK1D GRID2 ATP10A C2CD2	1.77e-05	185	195	7	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 SEMA6D NHS FGD5 GRIK1 RGS12 IGF1	1.77e-05	185	195	7	79cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
ToppCell	COVID-19-Fibroblasts-Pericytes\|COVID-19 / group, cell type (main and fine annotations)	SEMA6D ADAMTS9 AGAP1 CACNA1C CNTN4 SGIP1 PREX2	1.77e-05	185	195	7	4905adaeeffd353e089578e5ea614437dbe794e6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M ARID5A SGIP1 CAMK1D GRID2 ATP10A C2CD2	1.77e-05	185	195	7	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD4 NHS CNTN4 KIF21A ABCC6 LRP2 MAP3K13	1.83e-05	186	195	7	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ACADSB RNF43 CAMK1D ABCC6 MAP3K13 LRBA AGAP9	1.89e-05	187	195	7	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNF43 TRIM66 RICTOR TTLL4 TLR5 LRP2 PPIP5K1	1.89e-05	187	195	7	f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IFT140 PECAM1 RTN1 NEDD4 FGD5 PREX1 PREX2	2.03e-05	189	195	7	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	SEMA6D ADAMTS9 AGAP1 CACNA1C CNTN4 SGIP1 PREX2	2.03e-05	189	195	7	d7ed96add29f219183c802895fbff519b627f635
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SEMA6D ADAMTS9 AGAP1 CACNA1C CNTN4 SGIP1 PREX2	2.10e-05	190	195	7	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SEMA6D ADAMTS9 AGAP1 CACNA1C CNTN4 SGIP1 PREX2	2.10e-05	190	195	7	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NHS AGAP1 CNTN4 ABCC6 LRP2 NINL MAP3K13	2.17e-05	191	195	7	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NHS AGAP1 CNTN4 ABCC6 LRP2 NINL MAP3K13	2.17e-05	191	195	7	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	ARHGEF38 ZNRF3 C4BPA GPC5 ABCC6 LRP2 MAP3K13	2.17e-05	191	195	7	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NHS GRIK1 RGS12 PREX2 IGF1 NINL PRRT4	2.24e-05	192	195	7	bf1943715085c4124b1675888b0615c9500ec888
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B NHS FGD5 VWA5B1 RGS12 IGF1	2.24e-05	192	195	7	025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS9 NHS GRIK1 PREX2 IGF1 SP9 PRRT4	2.24e-05	192	195	7	67d6230e32d446dcb12047fae2c3f1faa80dd720
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	RTN1 CD163 BRCA2 ANLN PREX1 CAMK1D SIPA1L1	2.32e-05	193	195	7	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Pax6\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SP8 ADAMTS9 NHS GRIK1 RGS12 IGF1	2.34e-05	130	195	6	60e28d452d0e2af768459ba8dbe998117c94a251
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RTN1 KCNH1 PKD1 CACNA1C CNTN4 PAK5 SLC2A13	2.56e-05	196	195	7	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Influenza-Influenza_Severe-Lymphocyte-B-Plasmablast\|Influenza_Severe / Disease, condition lineage and cell class	IGSF10 ANLN IGKV1-8 KIF20A IGF1 IGHA1 LTF	2.64e-05	197	195	7	9108edafbf5744ed65f556bcbbf819a9b71176a9
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	A2M NHS CACNA1C SGIP1 ADAM12 CEMIP IGF1	2.64e-05	197	195	7	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 NHS GRIK1 RGS12 PREX2 IGF1 NINL	2.91e-05	200	195	7	d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 SMG1 MYCBP2 BIRC6 BOD1L1 DYNC1H1 MACF1	2.91e-05	200	195	7	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 NHS GRIK1 RGS12 PREX2 IGF1 NINL	2.91e-05	200	195	7	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-QPCT\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 SEMA6D FGD5 VWA5B1 RGS12 SLC6A2 IGF1	2.91e-05	200	195	7	85e1b598c9f3976215b20eeda077d8aab621cce6
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 ADRA1B FGD5 RGS12 PREX2 IGF1 LPIN2	2.91e-05	200	195	7	1d67c5d2c617749b521e70879950dea2c9d076d6
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADRA1B SEMA6D NHS GRIK1 RGS12 PREX2 NINL	2.91e-05	200	195	7	53d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-QPCT-L2-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 SEMA6D FGD5 VWA5B1 RGS12 SLC6A2 IGF1	2.91e-05	200	195	7	2f2c5331511a924fa0bb1689f4c81641d754c9b9
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 ADRA1B FGD5 RGS12 PREX2 IGF1 LPIN2	2.91e-05	200	195	7	26c7f2b0afe9e50f2a5c43918ad8e91d7553b72c
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NHS GRIK1 RGS12 PREX2 IGF1 NINL PRRT4	2.91e-05	200	195	7	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-OPRM1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 ADRA1B FGD5 RGS12 PREX2 SLC6A2 IGF1	2.91e-05	200	195	7	559cf4001a3f985c8357f0102b34fab2e34d2a04
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-OPRM1-L1-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 ADRA1B FGD5 RGS12 PREX2 SLC6A2 IGF1	2.91e-05	200	195	7	cc0d639d38eb99414ba8b54d3000701962394465
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SP8 ADRA1B NHS FGD5 RGS12 PREX2 IGF1	2.91e-05	200	195	7	75649534a98bc738fca62d071de0978dc61eb24f
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Serpinf1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ARID5A IGSF10 SP8 CNTN4 IGF1 SP9	5.04e-05	149	195	6	5293c50b3fb41b1edaf9a97354899bd13770078c
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122\|Adult / Lineage, Cell type, age group and donor	ARHGEF38 USP44 ZGPAT ADRA1B AGAP1 OBSL1	6.74e-05	157	195	6	31d1bd9138c60e8485664ec4144f987226e3eef9
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SP8 ADRA1B NHS RGS12 IGF1 SLC2A13	7.22e-05	159	195	6	7f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	ADAMTS9 NHS CACNA1C ATP10A IGHA1 SUSD2	7.48e-05	160	195	6	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	ADAMTS9 NHS CACNA1C CNTN4 SGIP1 ATP10A	7.74e-05	161	195	6	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC5A6 NHS FGD5 GRIK1 SP9 SLC2A13	7.74e-05	161	195	6	b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	A2M ARID5A SP8 IGF1 VWA5A SP9	8.29e-05	163	195	6	bba830a302919c8b33f914a8839877fc21dd28a0
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PECAM1 BARD1 AWAT2 CLCA1 ANLN PREX2	8.29e-05	163	195	6	7864e966c228282b4b63c43164dba3faba21026d
ToppCell	Frontal_cortex\|World / BrainAtlas - Mouse McCarroll V32	ERFE ADRA1B KCNH1 ADAM12 KCNV1 SIPA1L1	8.57e-05	164	195	6	e09291711abf8680e78170328313719092b0142f
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ARID5A SP8 NFIX GRIK1 IGF1 SP9	8.57e-05	164	195	6	08819970174a3eb4eee8e1e675075828665b845e
ToppCell	RSV-Healthy-6\|Healthy / Virus stimulation, Condition and Cluster	PCNX3 LINC01547 NHS KHNYN POM121C C2CD2	8.57e-05	164	195	6	1b9c5a6dc4e09b90f92e98b81a5ee620f8479cc7
ToppCell	RSV-Healthy-6\|RSV / Virus stimulation, Condition and Cluster	PCNX3 LINC01547 NHS KHNYN POM121C C2CD2	8.57e-05	164	195	6	ab312b8c2f828ea7331f2a340c4df81587a23b5c
ToppCell	mild_COVID-19_(asymptomatic)-Plasmablast\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	IGKV1D-8 IGHV2-5 GMNN KIF20A IGF1 IGHA1	9.16e-05	166	195	6	0cc3b9681bc000a1b00d3b60f79f16eea1c2e2e1
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PCNX3 RNF43 SLC5A6 HEATR5B TTLL4 FAM199X	9.47e-05	167	195	6	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	mild_COVID-19_(asymptomatic)-Plasmablast\|World / disease group, cell group and cell class (v2)	IGKV1D-8 IGHV2-5 GMNN KIF20A IGF1 IGHA1	9.47e-05	167	195	6	f26ae4de4804a3486502e3df37eabf3dfca688f5
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SP8 NHS GRIK1 IGF1 SP9 PRRT4	9.47e-05	167	195	6	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	ARHGEF38 USP44 ADRA1B GPC5 AGAP1 MAP3K13	1.04e-04	170	195	6	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CD55 TLR7 C4BPA AGAP1 CNTN4 LPIN2	1.04e-04	170	195	6	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	A2M KRT26 ACADSB ADRA1B IGF1 MACF1	1.04e-04	170	195	6	e20568c8f3f17d94de78229617eb2f7e4c5af2bc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SP8 ADRA1B FGD5 RGS12 SLC6A2 IGF1	1.04e-04	170	195	6	28e22f9ef58423acc0fb8de1aff958b116dd33e9
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	SEMA6D ADAMTS9 CACNA1C CNTN4 SGIP1 PREX2	1.08e-04	171	195	6	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	A2M ADAMTS9 NHS CACNA1C CNTN4 ATP10A	1.08e-04	171	195	6	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-Unfolded_protein_responsible_cell\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ERCC5 PRAG1 USP44 METTL4 C2CD2	1.08e-04	107	195	5	7fee0193ee02e9cc62f506660ea7ec23fb4d0c84
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF38 PRAG1 ADAMTS9 NHS KCNV1 LTF	1.11e-04	172	195	6	eeed177a03c116e9815a8e086d24efc9643b16a4
Disease	cerebral palsy (implicated_via_orthology)	AGAP4 AGAP1 AGAP9 AGAP7P AGAP6	2.44e-09	10	188	5	DOID:1969 (implicated_via_orthology)
Disease	Autistic Disorder	ACADSB PECAM1 CUL7 MBD4 AGAP1 CACNA1C CNTN4 HTR1D ATP10A IGF1	7.41e-06	261	188	10	C0004352
Disease	hair color	TET2 SPIRE2 ALX4 SEMA6D KCNH1 BANP HERC2 RAD51B CNTN4 CDK5RAP1	3.35e-05	311	188	10	EFO_0003924
Disease	Malignant neoplasm of breast	ARHGEF38 BARD1 NEDD4 BRCA2 KCNH1 NHS BOD1L1 OXSM FGD5 HERC2 RAD51B KRT14 TRAPPC8 ADAM12 IGF1 SIPA1L1 MACF1 MAP3K13 LRBA	6.12e-05	1074	188	19	C0006142
Disease	epilepsy (implicated_via_orthology)	KCNH1 MAP4K4 DYNC1H1 SLC12A6 SLC12A3 SLC12A4 SLC12A7	8.79e-05	163	188	7	DOID:1826 (implicated_via_orthology)
Disease	Osteopenia	SLC5A6 IGF1 LRP2	1.09e-04	15	188	3	C0029453
Disease	3-M syndrome	CUL7 OBSL1	1.21e-04	3	188	2	cv:C1848862
Disease	3-M syndrome (is_implicated_in)	CUL7 OBSL1	1.21e-04	3	188	2	DOID:0060241 (is_implicated_in)
Disease	cortical surface area measurement	TET2 SPIRE2 PCNX3 MYCBP2 GPR135 TTC34 ALX4 SP8 ADAMTS9 NFIX PKD1 MAP4K4 ARHGAP21 AGAP1 RAD51B HTR1D KHNYN ADAM12 IGF1 MACF1 PAX7	1.45e-04	1345	188	21	EFO_0010736
Disease	esophagus squamous cell carcinoma (is_implicated_in)	TET2 BRCA2 MBD4 RICTOR	1.94e-04	45	188	4	DOID:3748 (is_implicated_in)
Disease	uveal melanoma (is_implicated_in)	BRCA2 MBD4	2.40e-04	4	188	2	DOID:6039 (is_implicated_in)
Disease	Bipolar Disorder	NEDD4 SP8 BRCA2 NFIX SLC12A6 CACNA1C CNTN4 GRIK1 SLC6A2 IGF1 CTLA4	2.61e-04	477	188	11	C0005586
Disease	unipolar depression, memory performance, cognitive function measurement	GPC5 CNTN4 TRAPPC8	2.68e-04	20	188	3	EFO_0003761, EFO_0004874, EFO_0008354
Disease	COVID-19 (is_implicated_in)	A2M TLR7 C4BPA	3.11e-04	21	188	3	DOID:0080600 (is_implicated_in)
Disease	lung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma	TET2 BRCA2 KCNH1 RAD51B	3.40e-04	52	188	4	EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Disease	Libman-Sacks Disease	PCNX3 PHRF1 TLR5 CTLA4	5.18e-04	58	188	4	C0242380
Disease	mitochondrial myopathy (implicated_via_orthology)	COX10 ISCU	5.96e-04	6	188	2	DOID:699 (implicated_via_orthology)
Disease	age at diagnosis, substance-related disorder	BIRC6 SEMA6D	5.96e-04	6	188	2	EFO_0004918, MONDO_0002494
Disease	malaria (is_marker_for)	CD163 CTLA4	5.96e-04	6	188	2	DOID:12365 (is_marker_for)
Disease	cortical thickness	A2M SPIRE2 GALK2 MYCBP2 TTC34 ALX4 SP8 ADAMTS9 NFIX PKD1 ARHGAP21 AGAP1 RAD51B HTR1D ADAM12 MACF1 PAX7	8.08e-04	1113	188	17	EFO_0004840
Disease	waist-hip ratio	TET2 MYCBP2 BIRC6 CFAP65 TRIM66 SP8 ZNRF3 ADAMTS9 NFIX SEMA3B PKD1 ARHGAP21 RAD51B SLC17A4 CEP192 TRIM7 CEMIP IGF1	8.93e-04	1226	188	18	EFO_0004343
Disease	alpha-2-macroglobulin measurement	A2M TET2	1.10e-03	8	188	2	EFO_0020138
Disease	Lupus Erythematosus, Systemic	PCNX3 PHRF1 TLR5 CTLA4	1.11e-03	71	188	4	C0024141
Disease	disease recurrence, unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement	TTC34 PAK5 ADAM12	1.21e-03	33	188	3	EFO_0003761, EFO_0004952, EFO_0008343, MONDO_0004985, MONDO_0005090
Disease	melanoma (is_implicated_in)	ERCC5 BRCA2 CTLA4	1.32e-03	34	188	3	DOID:1909 (is_implicated_in)
Disease	Abnormality of refraction	SMG1 BIRC6 NEDD4 ZGPAT ADAMTS9 NFIX PZP PHRF1 COX10 GRIK1 IGF1 ISCU	1.34e-03	673	188	12	HP_0000539
Disease	influenza A severity measurement	PRAG1 ZFYVE28	1.41e-03	9	188	2	EFO_0007743
Disease	Gastrointestinal Hemorrhage	SLC5A6 LTF	1.41e-03	9	188	2	C0017181
Disease	interleukin 1 receptor-like 2 measurement	MAP4K4 IGKV1-8	1.41e-03	9	188	2	EFO_0008169
Disease	neuroimaging measurement	SPIRE2 TTC34 ALX4 SP8 ZNRF3 NFIX PKD1 AGAP1 RAD51B HTR1D PAK5 METTL4 POM121C NINL MACF1 PAX7	1.42e-03	1069	188	16	EFO_0004346
Disease	Inherited focal segmental glomerulosclerosis	ANLN LMX1B	1.76e-03	10	188	2	cv:CN327126
Disease	Focal segmental glomerulosclerosis	ANLN LMX1B	1.76e-03	10	188	2	cv:C0017668
Disease	urate measurement	PCNX3 BIRC6 GJA10 HEATR5B TECPR1 SLC17A4 GRIK1 CEMIP SMU1 LRP2 NINL TMF1 SENP2 PAX7	1.87e-03	895	188	14	EFO_0004531
Disease	cigarettes per day measurement	SPIRE2 MEIOB SEMA6D USP4 POM121C RGS12 PREX2 SIPA1L1 LRBA	2.08e-03	438	188	9	EFO_0006525
Disease	Systemic lupus erythematosus	TLR5 CTLA4	2.14e-03	11	188	2	cv:C0024141
Disease	Hereditary Nephrotic Syndromes, Autosomal Dominant	ANLN LMX1B	2.14e-03	11	188	2	cv:CN043612
Disease	X-18913 measurement	SP8 KRTAP11-1	2.14e-03	11	188	2	EFO_0800795
Disease	Neoplasm of uncertain or unknown behavior of breast	BRCA2 HERC2 MAP3K13	2.27e-03	41	188	3	C0496956
Disease	Breast adenocarcinoma	BRCA2 HERC2 MAP3K13	2.27e-03	41	188	3	C0858252
Disease	Kidney Diseases	ADRA1B IGF1 SLC12A3 LRP2	2.45e-03	88	188	4	C0022658
Disease	autoimmune thyroiditis (is_implicated_in)	LRP2 CTLA4	2.56e-03	12	188	2	DOID:7188 (is_implicated_in)
Disease	polycystic ovary syndrome (is_marker_for)	PECAM1 IGF1	2.56e-03	12	188	2	DOID:11612 (is_marker_for)
Disease	N-acetyl-2-aminooctanoate measurement	SP8 KRTAP11-1	2.56e-03	12	188	2	EFO_0800567
Disease	Seizures	ADRA1B SLC5A6 CUL4B GRIK1 SLC6A2 MACF1	2.82e-03	218	188	6	C0036572
Disease	Familial idiopathic steroid-resistant nephrotic syndrome	ANLN LMX1B	3.01e-03	13	188	2	cv:C4273714
Disease	Benign tumor of pancreas	RNF43 BRCA2	3.01e-03	13	188	2	C0347284
Disease	Graves ophthalmopathy (is_marker_for)	IGF1 CTLA4	3.01e-03	13	188	2	DOID:0081120 (is_marker_for)
Disease	body weight	TET2 ARHGEF38 TRIM66 SP8 ZGPAT SEMA6D ANLN PKD1 AGAP1 CACNA1C PAK5 GRID2 CEP192 POM121C CRB1 LMX1B SP9	3.02e-03	1261	188	17	EFO_0004338
Disease	colorectal cancer (is_marker_for)	TET2 AMER1 BRCA2 MAP4K4 RICTOR	3.40e-03	157	188	5	DOID:9256 (is_marker_for)
Disease	alcohol use disorder measurement, alcohol consumption measurement	TRIM66 SP8 SEMA6D CACNA1C	3.49e-03	97	188	4	EFO_0007878, EFO_0009458
Disease	upper face morphology measurement	TTC34 ALX4 LMX1B MACF1	3.49e-03	97	188	4	EFO_0010949
Disease	Metabolic Bone Disorder	IGF1 LRP2	3.49e-03	14	188	2	C0005944
Disease	membranous glomerulonephritis (biomarker_via_orthology)	A2M LRP2	3.49e-03	14	188	2	DOID:10976 (biomarker_via_orthology)
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BARD1 BRCA2	3.49e-03	14	188	2	C0677776
Disease	neuroticism measurement, cognitive function measurement	TET2 BIRC6 SEMA6D NFIX USP4 AGAP1 CACNA1C HTR1D VAC14 SIPA1L1	3.56e-03	566	188	10	EFO_0007660, EFO_0008354
Disease	schizophrenia, anorexia nervosa	SEMA6D CACNA1C CNTN4	3.57e-03	48	188	3	MONDO_0005090, MONDO_0005351
Disease	lung adenocarcinoma (is_implicated_in)	RNF43 ALX4 MAP4K4	3.78e-03	49	188	3	DOID:3910 (is_implicated_in)
Disease	reading and spelling ability	GALK2 SEMA6D KCNH1 GPC5 SLC12A3	4.31e-03	166	188	5	EFO_0005301
Disease	suntan	SPIRE2 HERC2 SGIP1 CRB1	4.32e-03	103	188	4	EFO_0004279
Disease	Seizures, Focal	ADRA1B DYNC1H1 GRIK1 SLC6A2	4.47e-03	104	188	4	C0751495
Disease	C-reactive protein measurement	CWF19L2 PRAG1 USP44 ZGPAT SLC5A6 PKD1 MAP4K4 GCN1 ARHGAP21 SGIP1 RICTOR CEP192 LMX1B SP9 MACF1 KRTAP11-1	4.64e-03	1206	188	16	EFO_0004458
Disease	PR interval	PCNX3 MYCBP2 METTL4 SIPA1L1 LPIN2 MACF1 SENP2 KRTAP11-1 SLC12A7	4.65e-03	495	188	9	EFO_0004462
Disease	monoclonal gammopathy	PREX1 RAD51B CNTN4	4.72e-03	53	188	3	EFO_0000203
Disease	Hypotension	ADRA1B HTR1D LTF	4.72e-03	53	188	3	C0020649
Disease	prostate carcinoma	TET2 IFT140 GPATCH8 RNF43 NEDD4 SP8 ZGPAT ANLN GPC5 CRAMP1 RAD51B LRRC8B AGAP7P	4.85e-03	891	188	13	EFO_0001663
Disease	Peripheral Nervous System Diseases	SLC12A6 IGF1 CTLA4	4.97e-03	54	188	3	C4721453
Disease	glycochenodeoxycholate measurement	ADAM12 CEMIP	5.16e-03	17	188	2	EFO_0010490
Disease	Hypogammaglobulinemia	CD55 CTLA4	5.16e-03	17	188	2	C0086438
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR7 TLR5	5.16e-03	17	188	2	DOID:8677 (biomarker_via_orthology)
Disease	Epilepsy	KCNH1 SLC5A6 VDAC2 P2RX2	5.28e-03	109	188	4	C0014544
Disease	aspartate aminotransferase measurement	WWC3 STRA8 PRAG1 BIRC6 CD163 ZGPAT ADAMTS9 GCN1 AGAP1 POM121C SLC17A5 CTLA4 LRBA	5.46e-03	904	188	13	EFO_0004736
Disease	intraocular pressure measurement	NEDD4 ZNRF3 BOD1L1 HERC2 RAD51B ADAM12 IGF1 LMX1B ISCU	5.56e-03	509	188	9	EFO_0004695
Disease	Bone marrow hypocellularity	BRCA2 FANCM	5.78e-03	18	188	2	C1855710
Disease	peritonsillar abscess	TET2 PRAG1	5.78e-03	18	188	2	EFO_0007429
Disease	response to tenofovir, creatinine clearance measurement	FGD5 PZP PREX1 GRID2	5.81e-03	112	188	4	EFO_0007934, EFO_0009279
Disease	response to efavirenz, virologic response measurement	ALX4 IGSF10 CAMK1D	6.07e-03	58	188	3	EFO_0006904, EFO_0006906
Disease	hepatocellular carcinoma (is_implicated_in)	TET2 RNF43 ALX4 MAP4K4 CTLA4	6.19e-03	181	188	5	DOID:684 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEASDSVSSCGQAGS	BANP	181	Q8N9N5
SGASSVTDFLSVSGA	ALX4	341	Q9H161
TGLGDSICFSPSISS	AGAP4	346	Q96P64
SEGFFLIGSTTSRCE	C4BPA	141	P04003
SSTDSASSCFKGGRE	LINC01547	176	P58512
LASGSSVSFVGASGC	ARID5A	221	Q03989
AISSDTGLGDSVCSS	AGAP1	491	Q9UPQ3
LGDSICFSPGISSTT	AGAP9	416	Q5VTM2
NGKVSSCTAAEGSFT	BIRC6	1541	Q9NR09
SCTAAEGSFTSLTGL	BIRC6	1546	Q9NR09
LASGSLTESECFGSL	BARD1	261	Q99728
IGDSSSSLSGTCGKF	ARHGEF38	686	Q9NXL2
SSLSGTCGKFETNGT	ARHGEF38	691	Q9NXL2
DSGSSGSRNSSCLDF	GJA10	446	Q969M2
NSTSGTTLSTDLECG	GRIK1	886	P39086
TCIATNHFGTASSTG	CNTN4	476	Q8IWV2
LTSVGTGLASCAANS	COX10	191	Q12887
TESGSDSECSLGLSG	BRPF3	1006	Q9ULD4
ISCSSFSSGGMFITT	BRWD3	321	Q6RI45
SGELGSSLSSESTCG	BRWD3	1606	Q6RI45
VGSFCLSEAGAGSDS	ACADSB	171	P45954
VTSLKSFDSLTGCGD	AMER1	316	Q5JTC6
RGYSDSAVSLSTCSG	ADAM12	126	O43184
SLDDSGSCLSGSQRT	ADRA1B	406	P35368
TLTCFPGATSTVAAG	CEMIP	21	Q8WUJ3
GFCSSASTLEGLSVS	DISP2	1281	A7MBM2
SCLTSGCSSIGSLAA	ATP10A	616	O60312
CLSEDAGLGISSTAS	A2M	771	P01023
TGLGDSICFSPSISS	AGAP6	346	Q5VW22
SLSEGTSGSSCVIAA	RAD51B	281	O15315
FCLSEDAGLGISSTA	PZP	776	P20742
KTFGCGSAIASSSLA	ISCU	91	Q9H1K1
SGAVSCSSSFGSVEE	ODF4	216	Q2M2E3
GGLDSATSISASCSQ	PAX7	411	P23759
SSFSCTLEGISSGGS	KRT26	41	Q7Z3Y9
EGTDGASLAGTSSCS	ZFYVE28	466	Q9HCC9
TGTLHSCSLTGSVAE	MEIOB	386	Q8N635
LGLADSGCVSFTADS	OBSL1	1601	O75147
GTSGCSKESLAYSES	PAK5	241	Q9P286
STACTTGAHAVGDSF	OXSM	206	Q9NWU1
SGTTVTSVVGFSCDG	MAP4K4	871	O95819
VALFCTTLSGDTSDT	MKKS	241	Q9NPJ1
GVTFSGSSSVCATSG	KRT84	511	Q9NSB2
GSSSVCATSGVLASC	KRT84	516	Q9NSB2
SGKLDFCSALSSQGS	NFIX	326	Q14938
ICSGSLSNFSTSDNG	NEDD4	146	P46934
DLDCASSSGSDLSGF	NEUROG1	11	Q92886
STLDTTGAGCAVATE	GPC5	541	P78333
CGSSHSAALTSSGEL	HERC2	3106	O95714
SVSSSRFSSGGACGL	KRT14	51	P02533
GTFTCIASNAAGEAT	LRFN1	366	Q9P244
GTACLSKFSSASGAS	ANLN	231	Q9NQW6
VNSGGSCLSASTVAI	CFAP65	86	Q6ZU64
DGSALEDSSTSGASC	FANCM	1781	Q8IYD8
GSGSGTDFTLTISCL	IGKV1D-8	86	A0A087WSZ0
LFGSTSSFCLISGSS	CD55	196	P08174
TTSGTTRLLSGHTCF	CD55	351	P08174
GSLTSLDSSVFCSEG	KCNV1	16	Q6PIU1
SCGTSVASSEGSEEL	FAM199X	71	Q6PEV8
NFSCASTSGVSGASA	FAM199X	266	Q6PEV8
TGATASCGLGSEFST	GPATCH8	241	Q9UKJ3
SIGCTSAGSLQSLAD	GRID2	96	O43424
GSSDSCFSGTDRETL	PCNX3	296	Q9H6A9
ASKSDSGTYICTAGI	PECAM1	376	P16284
SSSALVAQGSLCSGF	CWF19L2	391	Q2TBE0
LVSSLGKGSACSSTD	CUL7	1606	Q14999
GCSLTVRSGSHFSAV	ERFE	336	Q4G0M1
DNLSLSCVIGSSGSF	FGD5	581	Q6ZNL6
SSGLSSSSALVCCAG	GALK2	141	Q01415
GASCSTFFGSEERTV	PHRF1	946	Q9P1Y6
AGESVDSLCFVVSGS	KCNH1	611	O95259
EIGLCSSTSVQAASG	LRBA	946	P50851
EFGLVTTCGTGSSDF	LMLN2	441	A0A1B0GTW7
TTCGTGSSDFFCTGS	LMLN2	446	A0A1B0GTW7
DTLTTLCASSSGDDG	GCN1	1061	Q92616
GSSFIEGSTTECDAA	LRP2	4356	P98164
GVCVSSDTLDGNSSS	PABIR1	236	Q96E09
CSDGVSQEGSASSTK	RICTOR	1576	Q6R327
CTFSGFSLSTSGVGV	IGHV2-5	41	P01817
SSSGCSADIDSGKQS	LRRC8B	191	Q6P9F7
QSACSDTSESSAAGG	MACF1	7341	Q9UPN3
SAADFSGFGSTLATS	POM121C	891	A8CG34
GGLAFSDACTSTSIT	OR5AC2	66	Q9NZP5
FSGCRSESSLGTSHL	MAP3K13	781	O43283
GAFANLCTESTGFSS	MOGAT2	116	Q3SYC2
ATALTSVGVGSFLCD	P2RX2	346	Q9UBL9
CTGSEDSSEGFAISS	BOD1L1	1806	Q8NFC6
RSCSISEDSGLSTAF	ADAMTS9	416	Q9P2N4
DRGTYECIATSSTGS	IGSF10	1911	Q6WRI0
STGFTCSESTEAAAI	HEATR5B	1541	Q9P2D3
GGTSSAATAAVLSFS	GPR135	31	Q8IZ08
EGFCSSIHDTSVSAG	KLHL15	6	Q96M94
STGACSVSRSSIDFL	AWAT2	156	Q6E213
SFTLTSGSACGSSVL	C2CD2	361	Q9Y426
SGSACGSSVLGSVTA	C2CD2	366	Q9Y426
SNSTEGETPCGSSFA	CACNA1C	1486	Q13936
SANTCGIFSTASGKS	BRCA2	1971	P51587
SSSCGDTELLGQATL	C2CD2L	356	O14523
SVADSGDTAIGTSCS	CEP85	51	Q6P2H3
CSFSILSNSSVTGRG	CRAMP1	906	Q96RY5
TCTLTGLRDASGVTF	IGHA1	146	P01876
TAHLITGSAGSSLCS	HTR1D	241	P28221
TGLGDSICFSPSISS	AGAP7P	346	Q5VUJ5
SDAGACGETLSVTSE	MBD4	291	O95243
GTSSSGCALESFGSA	CEP192	1001	Q8TEP8
TTSQGATLDACSFGV	DYNC1H1	4546	Q14204
SSGASQCTGVLRDFS	KHNYN	151	O15037
GSGTDFTLTISCLQS	IGKV1-8	86	A0A0C4DH67
VTTTSTTDADCLGGI	KRTAP11-1	26	Q8IUC1
TFLDDSICTGTSSGN	CTLA4	96	P16410
TFTSSATAGPETLCG	IGF1	41	P05019
FLGSLSISSTPCDTF	GLB1L2	551	Q8IW92
TCGSVAASTGSAVAT	ELP4	6	Q96EB1
TGSLCEIATTLSFEG	CRB1	476	P82279
SACFVTSSLGGTDKE	CD163	36	Q86VB7
SFFSTCGAGLQSLTG	SLC12A6	576	Q9UHW9
SFFSTCGAGLQSLTG	SLC12A7	511	Q9Y666
LSSAISSFCESGALV	SLC17A4	401	Q9Y2C5
LTISTTLGGFCSSGF	SLC17A5	396	Q9NRA2
GIASLRCSSSGSTIS	IFT140	571	Q96RY7
PSTSSFCLGVSVAAS	CUL4B	96	Q13620
DSVSSSGVCAAFIAS	METTL4	51	Q8N3J2
SGVCAAFIASDSSTK	METTL4	56	Q8N3J2
RVHTCSAAGGFSTSD	PKD1	3766	P98161
VSIFCSGDSSISFSA	OR52I1	86	Q8NGK6
IGTCAEGTVSSSTDA	GMNN	191	O75496
AGECSLLAAAESSTS	SLC2A13	36	Q96QE2
FTTGITCLGSVSALS	NNT	801	Q13423
DSSCNSSDGVLVTFS	RUSC2	271	Q8N2Y8
TSKDGEGSCYTSLIS	RTN1	96	Q16799
ACGSSDGAISLLTYT	SEC13	121	P55735
TSSINCITSFVSGFA	SLC6A2	346	P23975
GEVFSNSSSCELTGS	SENP2	96	Q9HC62
SCDSSFSSGISVFTA	VAC14	371	Q08AM6
FDVAATGSLSTGTAT	SUSD2	691	Q9UGT4
SLAGAETSTCQADGT	SUSD2	756	Q9UGT4
SETASFAALSGGTLS	RNF19B	511	Q6ZMZ0
LLFLAVSSLGSCSTG	PRSS29P	41	A6NIE9
SGLSEGSVTCSSAST	LTF	381	P02788
GCVSGTTTAEAENTS	SYNRG	251	Q9UMZ2
ETSTGSLCKESFSGQ	FNBP4	666	Q8N3X1
SGSCDISSNSDTFGS	NHS	591	Q6T4R5
DSSSSGSAAGKDCIT	ABCC6	616	O95255
IACLFSGSLSTISSA	SLC5A6	356	Q9Y289
ASQSETSVCSGSLDG	TAF1B	181	Q53T94
CGTFSKTLSGSSSLE	SMG1	3036	Q96Q15
GFLGETCLSESSDGS	ERCC5	1086	P28715
TSGGSCDASLAEEAS	PREX1	1111	Q8TCU6
SLQGVHGSSSTFCSS	RNF43	486	Q68DV7
LSKSNSGSFSGCESA	SIPA1L1	431	O43166
SGSFSGCESASFEST	SIPA1L1	436	O43166
LASSASGAESSFTLA	SPATA31D4	156	Q6ZUB0
SRSGTELSAVGSVCS	MYCBP2	4361	O75592
CSSLRLFSSIDDGSG	NINL	306	Q9Y2I6
STLCSFISSSSGVSG	CAMK1D	351	Q8IU85
SCNLGSSLSGFAVAT	SP9	56	P0CG40
GSGAANSAFCLASTS	SP9	81	P0CG40
SFFSTCGAGLQSLTG	SLC12A4	511	Q9UP95
SSGTFLSGLSDCTNV	RRP12	91	Q5JTH9
SASCNVVGSSLSSFG	SP8	41	Q8IXZ3
DSGVDSQGASCSLVS	STRA8	226	Q7Z7C7
TDLLSSSLGTSGVDC	ARNTL	21	O00327
DSGFSDGSSECLSSA	CIPC	41	Q9C0C6
VCFSRTSSGGSFVAS	CLCA1	726	A8K7I4
VSLSSDFIAGFCGET	CDK5RAP1	436	Q96SZ6
LASSASGAESSFTLA	SPATA31D3	156	P0C874
SLCVSGETLAAGTSS	TMF1	156	P82094
SASLIANGDSTSTCG	USP4	256	Q13107
DTNTRVLASCGFSSG	TRIM7	381	Q9C029
EGESSSLNCSYTVSG	TRAV20	36	A0A0B4J274
GSVSSAGSLDLSEAC	RGS12	936	O14924
TECSNTFKSLGSTAG	SMU1	381	Q2TAY7
SANFGGTLSTSICFD	TRO	946	Q12816
GTLSTSICFDGSPST	TRO	951	Q12816
SADFGGTLSTSVCFG	TRO	996	Q12816
GAVSTSACFSGAPIT	TRO	1081	Q12816
TSSGQVTLGDACSAS	KIF21A	1426	Q7Z4S6
SFDSGIAGLSSISQC	KIF20A	256	O95235
FTSEGSTLSGCDIEL	SGIP1	791	Q9BQI5
VFSTSSSIFQGSAVC	SEMA3B	326	Q13214
TSCINLSVTDAGGSA	SPIRE2	386	Q8WWL2
SGSSSSLLSAGCFFG	TECPR1	386	Q7Z6L1
ETSTGCLFAGSSLGK	RTCA	251	O00442
SCSGVEFSTSGSSNT	VDAC2	46	P45880
VSSGSFCGLSRDSSS	PRRT4	801	C9JH25
GDATLCSGRFTISTL	SLC12A3	11	P55017
EDCSSATSGSVGANS	TMCC1	421	O94876
FSGGCDLSGITDSSE	SERPINI2	311	O75830
CFSFGIGEGTSTSLI	VWA5A	416	O00534
TACSASGVGLLSVSS	PREX2	1501	Q70Z35
TSEAAISSDGLSCGS	PRAG1	331	Q86YV5
SGDSSEVGFCSNART	TLR7	436	Q9NYK1
GVCGKTFSSGSSRTV	ZNF471	406	Q9BX82
EGSCGALDTLSSSST	ZNRF3	276	Q9ULT6
VCTALISSASSVDFG	TRAPPC8	991	Q9Y2L5
GSFFVTGSSCGDLTV	WDSUB1	151	Q8N9V3
FSGVSLFSLSTEGCD	TLR5	616	O60602
SCTDSSGSFAKLNGL	SEMA6D	706	Q8NFY4
GSFLLIIECGTESSS	TRIM66	891	O15016
TLCSSGTTAVIAGHS	TTLL4	86	Q14679
GSELSCTEGSLTSSL	ARHGAP21	1671	Q5T5U3
LASGEEFCSGSSSNL	TET2	346	Q6N021
GYCSLSVLASGSSAC	TTC34	411	A8MYJ7
CLSLSLFVTGSADGS	WDR87	576	Q6ZQQ6
VVGSDAVDSGTCSSA	ZGPAT	311	Q8N5A5
STESLISSLGLGAFC	TMEM267	16	Q0VDI3
DTGFVCSRQSSLSSG	USP44	341	Q9H0E7
SQCTGLFSTTVLGGS	PPIP5K1	1021	Q6PFW1
LCASTLTVSSGSSRG	WWC3	356	Q9ULE0
TASDVTSCVSGYALG	VWA5B1	16	Q5TIE3
SDTSLTSLSDCFLGS	LMX1B	361	O60663
TSLSDCFLGSSDVGS	LMX1B	366	O60663
SVGSAAADSGTECLS	LPIN2	446	Q92539