Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled amine receptor activity

TAAR1 HTR1B HTR2A

1.22e-0441473GO:0008227
GeneOntologyMolecularFunctionchannel activity

CACNA1I GJB2 HTR1B TMEM120A NALCN TRPM3 TRPM2

2.11e-04525477GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1I GJB2 HTR1B TMEM120A NALCN TRPM3 TRPM2

2.13e-04526477GO:0022803
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1I HTR1B TRPM3 TRPM2

2.39e-04129474GO:0005262
GeneOntologyMolecularFunctionguanylate cyclase activity

GUCY2F GUCY2D

2.41e-0410472GO:0004383
GeneOntologyMolecularFunctionsodium channel activity

CACNA1I NALCN TRPM2

2.49e-0452473GO:0005272
GeneOntologyMolecularFunctionJUN kinase kinase kinase activity

MAP3K1 LRRK2

3.53e-0412472GO:0004706
GeneOntologyMolecularFunctionserotonin binding

HTR1B HTR2A

4.16e-0413472GO:0051378
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1I HTR1B TRPM3 TRPM2

4.35e-04151474GO:0015085
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1I HTR1B TMEM120A NALCN TRPM3 TRPM2

6.90e-04459476GO:0005216
GeneOntologyMolecularFunctionadenylate cyclase activity

GUCY2F GUCY2D

8.10e-0418472GO:0004016
GeneOntologyMolecularFunctionamine binding

HTR1B HTR2A

1.11e-0321472GO:0043176
GeneOntologyMolecularFunctionG protein-coupled serotonin receptor activity

HTR1B HTR2A

1.22e-0322472GO:0004993
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1I HTR1B NALCN TRPM3 TRPM2

1.23e-03343475GO:0005261
GeneOntologyMolecularFunctionsyntaxin-1 binding

PRRT2 LRRK2

1.45e-0324472GO:0017075
GeneOntologyMolecularFunctioncyclase activity

GUCY2F GUCY2D

1.45e-0324472GO:0009975
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF22 PRAMEF19 RPTOR

1.45e-0395473GO:0140767
GeneOntologyMolecularFunctionlyase activity

GUCY2F PAICS GUCY2D CA3

1.54e-03212474GO:0016829
GeneOntologyMolecularFunctionphosphorus-oxygen lyase activity

GUCY2F GUCY2D

1.57e-0325472GO:0016849
GeneOntologyMolecularFunctionneurotransmitter receptor activity

HTR1B DRD5 HTR2A

1.68e-03100473GO:0030594
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

CACNA1I NALCN

1.70e-0326472GO:0005248
GeneOntologyMolecularFunctionMAP kinase kinase kinase activity

MAP3K1 LRRK2

1.83e-0327472GO:0004709
GeneOntologyMolecularFunctionprotein kinase activity

HIPK4 KIT GUCY2F MAP3K1 GUCY2D LRRK2

2.71e-03600476GO:0004672
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1I HTR1B NALCN TRPM3 TRPM2

4.60e-03465475GO:0046873
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1I HTR1B

5.25e-0346472GO:0005245
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

HIPK4 KIT GUCY2F MAP3K1 GUCY2D CDS2 LRRK2

6.01e-03938477GO:0016772
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

HIPK4 KIT GUCY2F MAP3K1 GUCY2D LRRK2

6.10e-03709476GO:0016773
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF22 PRAMEF19

7.44e-0355472GO:0042974
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

CACNA1I NALCN TRPM2

7.59e-03171473GO:0015081
GeneOntologyMolecularFunctionkinase activity

HIPK4 KIT GUCY2F MAP3K1 GUCY2D LRRK2

8.68e-03764476GO:0016301
GeneOntologyMolecularFunctiontransporter activity

CACNA1I GJB2 HTR1B TMEM120A NALCN TRPM3 TRPM2 CFHR4

9.75e-031289478GO:0005215
GeneOntologyBiologicalProcessdetection of external stimulus

TMEM120A HTR2A KIT GUCY2F GUCY2D CDS2

2.26e-06173466GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

TMEM120A HTR2A KIT GUCY2F GUCY2D CDS2

2.42e-06175466GO:0009582
GeneOntologyBiologicalProcesscellular response to dopamine

TAAR1 DRD5 HTR2A LRRK2

1.25e-0564464GO:1903351
GeneOntologyBiologicalProcessresponse to dopamine

TAAR1 DRD5 HTR2A LRRK2

1.41e-0566464GO:1903350
GeneOntologyBiologicalProcesscellular response to monoamine stimulus

TAAR1 DRD5 HTR2A LRRK2

1.59e-0568464GO:0071868
GeneOntologyBiologicalProcesscellular response to catecholamine stimulus

TAAR1 DRD5 HTR2A LRRK2

1.59e-0568464GO:0071870
GeneOntologyBiologicalProcessresponse to catecholamine

TAAR1 DRD5 HTR2A LRRK2

2.11e-0573464GO:0071869
GeneOntologyBiologicalProcessresponse to monoamine

TAAR1 DRD5 HTR2A LRRK2

2.22e-0574464GO:0071867
GeneOntologyBiologicalProcessresponse to abiotic stimulus

IER5 HTR1B TMEM120A DRD5 HTR2A KIT GUCY2F RPAIN RPTOR GUCY2D CDS2 TRPM2

3.09e-0513614612GO:0009628
GeneOntologyBiologicalProcesssensitization

DRD5 HTR2A

4.85e-055462GO:0046960
GeneOntologyBiologicalProcesscellular response to temperature stimulus

HTR1B TRPM2

4.85e-055462GO:0071502
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

SPG11 HTR1B DRD5 HTR2A PRRT2 NALCN KIT LRRK2

9.68e-05663468GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

SPG11 HTR1B DRD5 HTR2A PRRT2 NALCN KIT LRRK2

9.78e-05664468GO:0099177
GeneOntologyBiologicalProcessG protein-coupled dopamine receptor signaling pathway

TAAR1 DRD5 LRRK2

1.29e-0444463GO:0007212
GeneOntologyBiologicalProcesspurine ribonucleotide metabolic process

HTR2A GUCY2F PAICS RPTOR GUCY2D CFHR4 LRRK2

1.29e-04512467GO:0009150
GeneOntologyBiologicalProcessribonucleotide metabolic process

HTR2A GUCY2F PAICS RPTOR GUCY2D CFHR4 LRRK2

1.65e-04533467GO:0009259
GeneOntologyBiologicalProcessribose phosphate metabolic process

HTR2A GUCY2F PAICS RPTOR GUCY2D CFHR4 LRRK2

1.79e-04540467GO:0019693
GeneOntologyBiologicalProcessresponse to light stimulus

DRD5 KIT GUCY2F RPAIN GUCY2D CDS2

1.94e-04382466GO:0009416
GeneOntologyBiologicalProcessregulation of opsin-mediated signaling pathway

GUCY2F GUCY2D

2.16e-0410462GO:0022400
GeneOntologyBiologicalProcessphototransduction

GUCY2F GUCY2D CDS2

2.25e-0453463GO:0007602
GeneOntologyBiologicalProcesscellular response to nitrogen compound

GJB2 TAAR1 HTR1B DRD5 HTR2A RPTOR TRPM2 LRRK2

2.30e-04752468GO:1901699
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

TMEM120A HTR2A KIT

2.79e-0457463GO:0050974
GeneOntologyBiologicalProcesscarbohydrate derivative metabolic process

NEU3 HTR2A KIT GUCY2F PAICS RPTOR PIGX GUCY2D CFHR4 LRRK2

3.03e-0412264610GO:1901135
GeneOntologyBiologicalProcesscGMP biosynthetic process

GUCY2F GUCY2D

3.17e-0412462GO:0006182
GeneOntologyBiologicalProcessreceptor guanylyl cyclase signaling pathway

GUCY2F GUCY2D

3.17e-0412462GO:0007168
GeneOntologyBiologicalProcessG protein-coupled opsin signaling pathway

GUCY2F GUCY2D

3.74e-0413462GO:0016056
GeneOntologyBiologicalProcessadenylate cyclase-activating dopamine receptor signaling pathway

TAAR1 DRD5

3.74e-0413462GO:0007191
GeneOntologyBiologicalProcessnegative regulation of synaptic transmission, glutamatergic

HTR1B HTR2A

3.74e-0413462GO:0051967
GeneOntologyBiologicalProcessnonassociative learning

DRD5 HTR2A

3.74e-0413462GO:0046958
GeneOntologyBiologicalProcessexocytosis

TRAPPC11 CACNA1I HTR1B PRRT2 KIT LRRK2

3.85e-04434466GO:0006887
GeneOntologyBiologicalProcessregulation of MAPK cascade

NLRP12 DRD5 HTR2A KIT PRAMEF22 PRAMEF19 MAP3K1 LRRK2

3.95e-04815468GO:0043408
GeneOntologyBiologicalProcesspurine nucleotide metabolic process

HTR2A GUCY2F PAICS RPTOR GUCY2D CFHR4 LRRK2

4.10e-04619467GO:0006163
GeneOntologyBiologicalProcessregulated exocytosis

CACNA1I HTR1B PRRT2 KIT LRRK2

4.61e-04291465GO:0045055
GeneOntologyBiologicalProcessneuromuscular junction development

KY SPG11 LRRK2

4.70e-0468463GO:0007528
GeneOntologyBiologicalProcesssecretion by cell

TRAPPC11 CACNA1I HTR1B HTR2A PRRT2 KIT RPTOR TRPM2 LRRK2

4.90e-041064469GO:0032940
GeneOntologyBiologicalProcessresponse to cocaine

HTR1B DRD5 HTR2A

5.34e-0471463GO:0042220
GeneOntologyBiologicalProcesspurine-containing compound metabolic process

HTR2A GUCY2F PAICS RPTOR GUCY2D CFHR4 LRRK2

5.59e-04652467GO:0072521
GeneOntologyBiologicalProcessdetection of mechanical stimulus

TMEM120A HTR2A KIT

6.26e-0475463GO:0050982
GeneOntologyBiologicalProcessdetection of light stimulus

GUCY2F GUCY2D CDS2

6.77e-0477463GO:0009583
GeneOntologyBiologicalProcessregulation of G protein-coupled receptor signaling pathway

HTR1B GUCY2F GUCY2D LRRK2

7.02e-04181464GO:0008277
GeneOntologyBiologicalProcessbehavior

SPG11 HTR1B DRD5 HTR2A KIT RPTOR PHF21A LRRK2

7.12e-04891468GO:0007610
GeneOntologyBiologicalProcessnucleotide metabolic process

HTR2A GUCY2F PAICS RPTOR GUCY2D CFHR4 LRRK2

7.43e-04684467GO:0009117
GeneOntologyBiologicalProcessnegative regulation of synaptic transmission

HTR1B DRD5 HTR2A

7.56e-0480463GO:0050805
GeneOntologyBiologicalProcessnucleoside phosphate metabolic process

HTR2A GUCY2F PAICS RPTOR GUCY2D CFHR4 LRRK2

7.88e-04691467GO:0006753
GeneOntologyBiologicalProcesscGMP metabolic process

GUCY2F GUCY2D

8.12e-0419462GO:0046068
GeneOntologyBiologicalProcessorganophosphate metabolic process

HTR2A GUCY2F PAICS RPTOR PIGX GUCY2D CDS2 CFHR4 LRRK2

8.15e-041142469GO:0019637
GeneOntologyBiologicalProcessresponse to radiation

DRD5 KIT GUCY2F RPAIN GUCY2D CDS2

8.36e-04503466GO:0009314
GeneOntologyBiologicalProcessexport from cell

TRAPPC11 CACNA1I HTR1B HTR2A PRRT2 KIT RPTOR TRPM2 LRRK2

8.73e-041153469GO:0140352
GeneOntologyBiologicalProcesscalcium ion transport

CACNA1I SPG11 HTR2A NALCN TRPM3 TRPM2

8.89e-04509466GO:0006816
GeneOntologyBiologicalProcessphototransduction, visible light

GUCY2F GUCY2D

9.01e-0420462GO:0007603
GeneOntologyBiologicalProcessMAPK cascade

NLRP12 DRD5 HTR2A KIT PRAMEF22 PRAMEF19 MAP3K1 LRRK2

9.41e-04930468GO:0000165
GeneOntologyBiologicalProcesscarbohydrate catabolic process

NEU3 HTR2A DHDH RPTOR

9.45e-04196464GO:0016052
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

SPG11 HTR1B DRD5 HTR2A PRRT2 NALCN KIT LRRK2

9.48e-04931468GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

SPG11 HTR1B DRD5 HTR2A PRRT2 NALCN KIT LRRK2

9.48e-04931468GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

SPG11 HTR1B DRD5 HTR2A PRRT2 NALCN KIT LRRK2

1.00e-03939468GO:0099537
GeneOntologyBiologicalProcessregulation of synaptic transmission, glutamatergic

HTR1B HTR2A LRRK2

1.13e-0392463GO:0051966
GeneOntologyBiologicalProcessresponse to temperature stimulus

IER5 HTR1B HTR2A TRPM2

1.18e-03208464GO:0009266
GeneOntologyBiologicalProcessG protein-coupled serotonin receptor signaling pathway

HTR1B HTR2A

1.19e-0323462GO:0098664
GeneOntologyBiologicalProcesscyclic nucleotide biosynthetic process

GUCY2F GUCY2D

1.19e-0323462GO:0009190
GeneOntologyBiologicalProcesssynaptic signaling

SPG11 HTR1B DRD5 HTR2A PRRT2 NALCN KIT LRRK2

1.28e-03976468GO:0099536
GeneOntologyBiologicalProcesssecretion

TRAPPC11 CACNA1I HTR1B HTR2A PRRT2 KIT RPTOR TRPM2 LRRK2

1.31e-031221469GO:0046903
GeneOntologyBiologicalProcessnucleobase-containing small molecule metabolic process

HTR2A GUCY2F PAICS RPTOR GUCY2D CFHR4 LRRK2

1.45e-03767467GO:0055086
GeneOntologyBiologicalProcesscellular response to chemical stress

GJB2 RPTOR GSR TRPM2 LRRK2

1.47e-03377465GO:0062197
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of pain

TMEM120A HTR2A

1.53e-0326462GO:0050966
GeneOntologyBiologicalProcessprotein autophosphorylation

NLRP12 HIPK4 KIT LRRK2

1.65e-03228464GO:0046777
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

CACNA1I HTR2A NALCN TRPM3 TRPM2

1.75e-03392465GO:0070588
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

KIT PRAMEF22 PRAMEF19

1.80e-03108463GO:0035019
GeneOntologyBiologicalProcessnegative regulation of transport

NEU3 HTR1B HTR2A PRRT2 RPTOR LRRK2

1.84e-03587466GO:0051051
GeneOntologyBiologicalProcesspositive regulation of glycolytic process

HTR2A RPTOR

1.90e-0329462GO:0045821
GeneOntologyBiologicalProcesspositive regulation of nucleotide catabolic process

HTR2A RPTOR

1.90e-0329462GO:0030813
GeneOntologyBiologicalProcesspositive regulation of purine nucleotide catabolic process

HTR2A RPTOR

1.90e-0329462GO:0033123
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

GJB2 TMEM120A HTR2A KIT

1.93e-03238464GO:0050954
GeneOntologyBiologicalProcesscellular response to organic cyclic compound

GJB2 TAAR1 DRD5 HTR2A TRPM2 LRRK2

2.15e-03605466GO:0071407
GeneOntologyBiologicalProcesspeptidyl-threonine phosphorylation

HIPK4 RPTOR LRRK2

2.15e-03115463GO:0018107
GeneOntologyBiologicalProcessglycolipid metabolic process

NEU3 KIT PIGX

2.37e-03119463GO:0006664
GeneOntologyBiologicalProcessregulation of anatomical structure size

HTR1B DRD5 HTR2A RPTOR MAP3K1 LRRK2

2.39e-03618466GO:0090066
GeneOntologyBiologicalProcessliposaccharide metabolic process

NEU3 KIT PIGX

2.43e-03120463GO:1903509
GeneOntologyBiologicalProcessvasoconstriction

HTR1B DRD5 HTR2A

2.49e-03121463GO:0042310
GeneOntologyBiologicalProcessregulation of dopamine secretion

HTR1B HTR2A

2.61e-0334462GO:0014059
GeneOntologyBiologicalProcesspeptidyl-threonine modification

HIPK4 RPTOR LRRK2

2.73e-03125463GO:0018210
GeneOntologyBiologicalProcesssynaptic vesicle exocytosis

HTR1B PRRT2 LRRK2

2.73e-03125463GO:0016079
GeneOntologyBiologicalProcessresponse to alkaloid

HTR1B DRD5 HTR2A

2.73e-03125463GO:0043279
GeneOntologyCellularComponentG protein-coupled serotonin receptor complex

HTR1B HTR2A

2.83e-054462GO:0098666
DomainHNOBA

GUCY2F GUCY2D

8.85e-056462PF07701
DomainHNOB_dom_associated

GUCY2F GUCY2D

8.85e-056462IPR011645
Domain7TM_GPCR_Srsx

TAAR1 HTR1B DRD5 HTR2A

1.65e-04112464SM01381
DomainIon_trans_dom

CACNA1I NALCN TRPM3 TRPM2

1.76e-04114464IPR005821
DomainIon_trans

CACNA1I NALCN TRPM3 TRPM2

1.76e-04114464PF00520
Domain5HT_rcpt

HTR1B HTR2A

2.11e-049462IPR002231
DomainZinc_finger_PHD-type_CS

TAF3 KDM5C PHF21A

5.49e-0465463IPR019786
Domain-

RNF223 TAF3 RNF166 KDM5C PHF21A MAP3K1

7.74e-044494663.30.40.10
DomainA/G_cyclase_CS

GUCY2F GUCY2D

7.88e-0417462IPR018297
DomainPHD

TAF3 KDM5C PHF21A

8.34e-0475463PF00628
DomainZnf_RING/FYVE/PHD

RNF223 TAF3 RNF166 KDM5C PHF21A MAP3K1

8.68e-04459466IPR013083
DomainNucleotide_cyclase

GUCY2F GUCY2D

8.85e-0418462IPR029787
Domain-

GUCY2F GUCY2D

8.85e-04184623.30.70.1230
DomainZnf_PHD-finger

TAF3 KDM5C PHF21A

9.70e-0479463IPR019787
DomainGUANYLATE_CYCLASE_2

GUCY2F GUCY2D

9.88e-0419462PS50125
DomainPRAME_family

PRAMEF22 PRAMEF19

9.88e-0419462IPR026271
DomainGUANYLATE_CYCLASE_1

GUCY2F GUCY2D

9.88e-0419462PS00452
DomainA/G_cyclase

GUCY2F GUCY2D

9.88e-0419462IPR001054
DomainCYCc

GUCY2F GUCY2D

9.88e-0419462SM00044
DomainGuanylate_cyc

GUCY2F GUCY2D

9.88e-0419462PF00211
DomainProt_kinase_dom

HIPK4 KIT GUCY2F MAP3K1 GUCY2D LRRK2

1.20e-03489466IPR000719
DomainPROTEIN_KINASE_DOM

HIPK4 KIT GUCY2F MAP3K1 GUCY2D LRRK2

1.26e-03493466PS50011
DomainPHD

TAF3 KDM5C PHF21A

1.37e-0389463SM00249
DomainZnf_PHD

TAF3 KDM5C PHF21A

1.46e-0391463IPR001965
DomainZF_PHD_2

TAF3 KDM5C PHF21A

1.65e-0395463PS50016
DomainZF_PHD_1

TAF3 KDM5C PHF21A

1.70e-0396463PS01359
DomainKinase-like_dom

HIPK4 KIT GUCY2F MAP3K1 GUCY2D LRRK2

2.03e-03542466IPR011009
DomainANF_receptor

GUCY2F GUCY2D

3.74e-0337462PF01094
DomainANF_lig-bd_rcpt

GUCY2F GUCY2D

3.74e-0337462IPR001828
DomainPkinase_Tyr

KIT GUCY2F GUCY2D

3.93e-03129463PF07714
DomainPeripla_BP_I

GUCY2F GUCY2D

4.15e-0339462IPR028082
DomainSer-Thr/Tyr_kinase_cat_dom

KIT GUCY2F GUCY2D

4.75e-03138463IPR001245
DomainZnf_FYVE_PHD

TAF3 KDM5C PHF21A

5.66e-03147463IPR011011
DomainRING

RNF223 RNF166 PHF21A MAP3K1

6.64e-03305464SM00184
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

TAAR1 HTR1B DRD5 HTR2A

4.19e-0642374M5868
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

TAAR1 HTR1B DRD5 HTR2A

4.19e-0642374MM14971
PathwayWP_MONOAMINE_GPCRS

HTR1B DRD5 HTR2A

8.60e-0533373M39585
PathwayWP_SEROTONIN_HTR1_GROUP_AND_FOS_PATHWAY

HTR1B HTR2A MAP3K1

1.22e-0437373M42558
PathwayREACTOME_SEROTONIN_RECEPTORS

HTR1B HTR2A

3.63e-0411372MM15008
PathwayREACTOME_SEROTONIN_RECEPTORS

HTR1B HTR2A

4.35e-0412372M6034
Pubmed

Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.

HTR1B DRD5 HTR2A

3.79e-071147318855532
Pubmed

Support for association between ADHD and two candidate genes: NET1 and DRD1.

HTR1B DRD5 HTR2A

3.79e-071147315717291
Pubmed

Endophenotypes and serotonergic polymorphisms associated with treatment response in obsessive-compulsive disorder.

HTR1B HTR2A

1.79e-06247222522758
Pubmed

Escitalopram reduces attentional performance in anxious older adults with high-expression genetic variants at serotonin 2A and 1B receptors.

HTR1B HTR2A

1.79e-06247222717018
Pubmed

Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.

GUCY2F GUCY2D

1.79e-0624727777544
Pubmed

[The role of genetic factors in the development of suicidal behavior in individuals with dependence on synthetic cathinones].

HTR1B HTR2A

1.79e-06247233244961
Pubmed

The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors.

GUCY2F GUCY2D

1.79e-06247217255100
Pubmed

Both 5-hydroxytryptamine 5-HT2A and 5-HT1B receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery.

HTR1B HTR2A

1.79e-06247218430065
Pubmed

Candidate gene studies of ADHD: a meta-analytic review.

HTR1B DRD5 HTR2A

1.86e-061847319506906
Pubmed

Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies.

HTR1B DRD5 HTR2A

3.02e-062147318270970
Pubmed

Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder.

HTR1B HTR2A

5.36e-06347216443280
Pubmed

Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample.

HTR1B HTR2A

5.36e-06347217093889
Pubmed

Prenatal activation of 5-HT2A receptor induces expression of 5-HT1B receptor in phrenic motoneurons and alters the organization of their premotor network in newborn mice.

HTR1B HTR2A

5.36e-06347218783379
Pubmed

Association study of serotonin system genes in childhood-onset mood disorder.

HTR1B HTR2A

5.36e-06347218349694
Pubmed

Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.

GUCY2F GUCY2D

5.36e-06347234537244
Pubmed

[Comparative Analysis of Polymorphisms of the Serotonin Receptor Genes HTR1A, HTR2A, and HTR1B in Hadza and Datoga Males].

HTR1B HTR2A

5.36e-06347226845861
Pubmed

Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial.

HTR1B HTR2A

5.36e-06347217503984
Pubmed

[Involvement of prefrontal serotonergic neurons in methamphetamine-induced behavioral sensitization].

HTR1B HTR2A

5.36e-06347218516987
Pubmed

Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.

HTR1B HTR2A

5.36e-06347214744462
Pubmed

Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.

HTR1B DRD5 HTR2A

7.40e-062847319352218
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

NLRP12 PRAMEF22 PRAMEF19

7.40e-062847325089626
Pubmed

RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells.

GUCY2F GUCY2D

1.07e-05447221078983
Pubmed

Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain.

HTR1B HTR2A

1.07e-05447228591153
Pubmed

An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population.

HTR1B HTR2A

1.07e-05447219897250
Pubmed

[Association of several polymorphic loci of serotoninergic genes with unipolar depression].

HTR1B HTR2A

1.07e-05447219639876
Pubmed

Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors.

GUCY2F GUCY2D

1.07e-05447222623665
Pubmed

Modulation of serotonergic receptor signaling and cross-talk by prion protein.

HTR1B HTR2A

1.07e-05447215590675
Pubmed

The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2.

GUCY2F GUCY2D

1.07e-0544729698373
Pubmed

Association study of seven polymorphisms in four serotonin receptor genes on suicide victims.

HTR1B HTR2A

1.07e-05447216856120
Pubmed

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.

HTR1B HTR2A

1.07e-05447228485378
Pubmed

Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy.

HTR1B HTR2A

1.78e-05547218253134
Pubmed

Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder.

HTR1B DRD5

1.78e-05547217501935
Pubmed

Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice.

GUCY2F GUCY2D

1.78e-05547223082185
Pubmed

No preferential transmission of paternal alleles at risk genes in attention-deficit hyperactivity disorder.

HTR1B DRD5

1.78e-05547217325714
Pubmed

An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors.

HTR1B HTR2A

1.78e-0554728833759
Pubmed

Duplication and positive selection among hominin-specific PRAME genes.

PRAMEF22 PRAMEF19

1.78e-05547216159394
Pubmed

Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice.

HTR1B HTR2A

1.78e-05547217250964
Pubmed

Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa.

HTR1B HTR2A

1.78e-05547220545463
Pubmed

Investigation of parent-of-origin effects in ADHD candidate genes.

HTR1B DRD5

1.78e-05547217427194
Pubmed

The Sensory Coding of Warm Perception.

TRPM3 TRPM2

1.78e-05547232208171
Pubmed

Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors.

GUCY2F GUCY2D

1.78e-05547221598940
Pubmed

Lack of association between five serotonin metabolism-related genes and medication overuse headache.

HTR1B HTR2A

1.78e-05547219936617
Pubmed

Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness.

GUCY2F GUCY2D

1.78e-05547231346032
Pubmed

Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.

GUCY2F GUCY2D

1.78e-05547227471269
Pubmed

Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice.

KIT RPTOR

1.78e-05547225438940
Pubmed

Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes.

HTR1B HTR2A

2.67e-05647216770336
Pubmed

Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.

HTR1B HTR2A

2.67e-05647228735749
Pubmed

Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch.

HTR2A KIT

2.67e-05647228807414
Pubmed

Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes.

HTR1B HTR2A

2.67e-05647212877392
Pubmed

A synaptic temperature sensor for body cooling.

TRPM3 TRPM2

2.67e-05647234672983
Pubmed

Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina.

GUCY2F GUCY2D

3.74e-0574728838319
Pubmed

Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms.

HTR1B HTR2A

3.74e-05747220071033
Pubmed

GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter.

KIT UPK1B CA3

3.83e-054847335905011
Pubmed

Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population.

HTR1B DRD5

4.98e-05847219673036
Pubmed

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.

HTR1B HTR2A

6.40e-05947219041748
Pubmed

Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice.

HTR1B DRD5

6.40e-0594728748389
Pubmed

Correlation of a set of gene variants, life events and personality features on adult ADHD severity.

DRD5 HTR2A

6.40e-05947220006992
Pubmed

A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.

HTR1B DRD5 HTR2A

6.77e-055847311140838
Pubmed

Neural basis of opioid-induced respiratory depression and its rescue.

DRD5 HTR2A

7.99e-051047234074761
Pubmed

Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study.

HTR1B HTR2A

7.99e-051047219032968
Pubmed

Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme.

KIT UPK1B CA3

8.68e-056347330916783
Pubmed

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.

TRPM3 TRPM2

1.17e-041247219850157
Pubmed

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

KIT KDM5C MAP3K1

1.24e-047147328319113
Pubmed

Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.

HTR1B HTR2A

1.38e-041347222569571
Pubmed

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.

TAF3 PHF21A

1.38e-041347220953165
Pubmed

Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning.

HTR1B HTR2A

1.38e-041347222640814
Pubmed

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.

TAAR1 HTR1B DRD5 HTR2A

1.56e-0420047418240029
Pubmed

Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5.

DRD5 KIT

1.61e-04144727919654
Pubmed

The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.

HTR1B HTR2A

1.61e-041447218937842
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF22 PRAMEF19

2.40e-041747223565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF22 PRAMEF19

2.40e-041747237781892
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF22 PRAMEF19

2.70e-041847223894331
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF22 PRAMEF19

2.70e-041847212890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF22 PRAMEF19

2.70e-041847229731491
Pubmed

Association study of the serotoninergic system in migraine in the Spanish population.

HTR1B HTR2A

2.70e-041847219455600
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF22 PRAMEF19

2.70e-041847214675769
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF22 PRAMEF19

2.70e-041847239181896
Pubmed

Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.

TRPM3 TRPM2

2.70e-041847231911949
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF22 PRAMEF19

3.01e-041947228604677
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

PAICS KDM5C MOV10 CDS2

3.22e-0424247434011540
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF22 PRAMEF19

3.34e-042047226694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF22 PRAMEF19

3.34e-042047216580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF22 PRAMEF19

3.34e-042047221425410
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF22 PRAMEF19

4.06e-042247231729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF22 PRAMEF19

4.44e-042347219480014
Pubmed

The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.

GUCY2F GUCY2D

4.44e-042347217954614
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM3 TRPM2

4.84e-042447233884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM3 TRPM2

5.26e-042547216382100
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF22 PRAMEF19

5.26e-042547237451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF22 PRAMEF19

5.26e-042547212620990
Pubmed

Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition.

GJB2 UPK1B

5.26e-042547217130451
Pubmed

Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.

HTR1B DRD5 HTR2A

5.54e-0411847319156168
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF22 PRAMEF19

5.69e-042647218500982
Pubmed

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.

KIT MOV10

5.69e-042647219898466
Pubmed

An introduction to TRP channels.

TRPM3 TRPM2

6.14e-042747216460286
Pubmed

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.

HTR1B HTR2A

6.14e-042747231806625
Pubmed

Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse.

GJB2 CA3

6.61e-042847220346939
Pubmed

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.

HTR1B HTR2A

6.61e-042847219737523
Pubmed

A common variant in DRD3 receptor is associated with autism spectrum disorder.

HTR1B DRD5 HTR2A

7.01e-0412847319058789
Pubmed

Genetical genomic determinants of alcohol consumption in rats and humans.

HTR1B DRD5 HTR2A

7.34e-0413047319874574
Cytoband1p36.21

PRAMEF22 PRAMEF19

1.93e-03634721p36.21
CytobandEnsembl 112 genes in cytogenetic band chr4q12

KIT PAICS

3.39e-0384472chr4q12
CytobandEnsembl 112 genes in cytogenetic band chr6q14

HTR1B UBE3D

4.49e-0397472chr6q14
GeneFamilyGuanylate cyclase receptors

GUCY2F GUCY2D

6.75e-057332343
GeneFamily5-hydroxytryptamine receptors, G protein-coupled

HTR1B HTR2A

2.49e-0413332170
GeneFamilyPHD finger proteins

TAF3 KDM5C PHF21A

5.84e-049033388
GeneFamilyPRAME family

PRAMEF22 PRAMEF19

8.70e-0424332686
GeneFamilyTransient receptor potential cation channels

TRPM3 TRPM2

1.19e-0328332249
CoexpressionAtlasstomach

RNF223 TAAR1 HTR1B DRD5 UPK1B

1.95e-05160445stomach
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 HTR1B HTR2A TRPM3 LRRK2

1.16e-0617647540993c41c1017b53039a337174fc56632b278609
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1I CDS2 GSR CA3

2.38e-05159474f7803f7b4e0379ae8256ec53110833bedee7db98
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1I CDS2 GSR CA3

2.38e-051594746e2d38e78d2ef7803e8bb154b5c788bf62a41045
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP12 MOV10 GSR TRPM2

2.50e-05161474e227f7b711475624cf80e77f235b1783d88d57b4
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP12 MOV10 GSR TRPM2

2.50e-051614748280a029026c272cae9649b27575831b0dd4e242
ToppCelldroplet-Lung-nan-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP12 MOV10 GSR TRPM2

2.69e-051644740e424a69999eee13d27c4ff4f4ba3df64d3c2bda
ToppCelldroplet-Lung-nan-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP12 MOV10 GSR TRPM2

2.69e-05164474fe9ecdd7a6cbaf910f42654eba75f79bea740a00
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTSL1 HTR2A KIT CA3

2.95e-05168474e40a3f85be7e9bb23bfbc1f9cb5e5fc54bb43863
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTSL1 HTR2A KIT CA3

2.95e-05168474b1d6c35a5ae69c8638afd68c2be5bc9ce6fd2659
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 HTR2A TRPM3 LRRK2

3.39e-05174474b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 HTR1B HTR2A LRRK2

3.39e-05174474ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 HTR1B HTR2A LRRK2

3.62e-05177474f902600c639087664316b3cf30cab243bc3d1c5c
ToppCellkidney_cells-Hypertensive_with+without-CKD|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 KIT MAP3K1 LRRK2

4.58e-0518847490188b60ff893754f7938fe8edab79758827168e
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 KIT TMEM116 COPRS

4.97e-051924744842a55650fc4687c9184d498a8c05c259d15186
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR1B HTR2A TRPM3 LRRK2

4.97e-0519247425460ca9ebd3d49f666394cf99ab77a5e8f77250
ComputationalGenes in the cancer module 65.

GUCY2F GUCY2D

2.31e-0410252MODULE_65
ComputationalGenes in the cancer module 445.

GUCY2F GUCY2D

5.35e-0415252MODULE_445
Drug1,2-dihydronaphthalene

DRD5 HTR2A DHDH

9.79e-0710473CID000009938
Drugspiroxatrine

HTR1B DRD5 HTR2A CA3

1.68e-0642474CID000005268
Drugergovaline

KY HTR1B DRD5

1.79e-0612473CID000104843
DrugUh 232

HTR1B DRD5 HTR2A

1.79e-0612473CID000123696
DrugErgot

TAAR1 HTR1B DRD5 HTR2A

2.90e-0648474CID000003250
DrugLisuride

HTR1B DRD5 HTR2A

2.95e-0614473DB00589
DrugPramipexole

HTR1B DRD5 HTR2A

2.95e-0614473DB00413
DrugRopinirole

HTR1B DRD5 HTR2A

2.95e-0614473DB00268
DrugCabergoline

HTR1B DRD5 HTR2A

3.69e-0615473DB00248
Drugelymoclavin

HTR1B DRD5 HTR2A

3.69e-0615473CID000011051
DrugApomorphine

HTR1B DRD5 HTR2A

3.69e-0615473DB00714
Drugphenoxybenzamine

HTR1B DRD5 HTR2A KDM5C GSR

3.90e-06115475CID000004768
DrugPergolide

HTR1B DRD5 HTR2A

5.49e-0617473DB01186
DrugBromocriptine

HTR1B DRD5 HTR2A

6.58e-0618473DB01200
Drugspermine NONOate

NLRP12 GUCY2F MAP3K1 CA3

7.63e-0661474CID000005259
Drugamisulpride

HTR1B DRD5 HTR2A

7.81e-0619473CID000002159
DrugVolkensin

HTR1B DRD5 HTR2A

7.81e-0619473CID006438338
DrugRP 62203

HTR1B DRD5 HTR2A

7.81e-0619473CID000060785
DrugSB 200646A

HTR1B DRD5 HTR2A

7.81e-0619473CID000126769
DrugSCH 39166

HTR1B DRD5 HTR2A

9.17e-0620473CID000107930
Drugsetoperone

HTR1B DRD5 HTR2A

1.24e-0522473CID000068604
DrugNSC662

NLRP12 GSR

1.25e-053472CID000022601
Drughydroxamates

CACNA1I DRD5 HTR2A

1.84e-0525473CID000033630
DrugOlanzapine

HTR1B DRD5 HTR2A

1.84e-0525473DB00334
DrugZiprasidone

HTR1B DRD5 HTR2A

1.84e-0525473DB00246
DrugAripiprazole

HTR1B DRD5 HTR2A

1.84e-0525473DB01238
Drugnitrofuran

NLRP12 PAICS GSR

1.84e-0525473CID000011865
DrugAC1L1H5B

HTR1B DRD5 HTR2A RPTOR

1.93e-0577474CID000003981
DrugQuetiapine

HTR1B DRD5 HTR2A

2.07e-0526473DB01224
DrugT15550

HTR1B DRD5 HTR2A

2.07e-0526473CID000005454
DrugAC1L1JND

TAAR1 HTR1B DRD5 HTR2A

2.14e-0579474CID000005118
Drugergolines

HTR1B DRD5 HTR2A

2.33e-0527473CID003083577
DrugNSC169490

HTR1B DRD5 HTR2A

2.33e-0527473CID004210613
DrugGR125743

HTR1B HTR2A

2.50e-054472CID005311130
DrugW50-30

HTR1B HTR2A

2.50e-054472CID000067500
DrugMetergoline

HTR1B HTR2A

2.50e-054472ctd:D008711
DrugSKF83959

DRD5 HTR2A

2.50e-054472CID000133538
DrugSKF 99101H

HTR1B HTR2A

2.50e-054472CID000182576
DrugL-741,626

HTR1B DRD5 HTR2A

2.60e-0528473CID000133633
Drugroxindole

HTR1B DRD5 HTR2A

2.60e-0528473CID000219050
DrugNSC407316

HTR1B DRD5 HTR2A

2.60e-0528473CID000003067
Drugprochlorperazine

HTR1B DRD5 HTR2A

2.90e-0529473CID000004917
Drugphenylethylamine

TAAR1 HTR1B DRD5 HTR2A

3.42e-0589474CID000001001
Drugmesulergine

HTR1B DRD5 HTR2A

3.56e-0531473CID000068848
DrugYM-09151-2

HTR1B DRD5 HTR2A

3.92e-0532473CID000004452
DrugGR 127935

HTR1B HTR2A

4.15e-055472ctd:C090701
DrugCP-135,807

HTR1B HTR2A

4.15e-055472CID005487088
Drugd-Isoboldine

HTR1B HTR2A

4.15e-055472CID000098369
DrugCP-132,484

HTR1B HTR2A

4.15e-055472CID000132564
Drugpirenperone

HTR1B DRD5 HTR2A

4.31e-0533473CID000004847
Drugmesoridazine

HTR1B DRD5 HTR2A

4.31e-0533473CID000004078
DrugCPPG

HTR1B HTR2A GSR

4.72e-0534473CID000002878
DrugCGS 12066B

HTR1B HTR2A MAP3K1

4.72e-0534473CID000002689
Drugtransdihydrolisuride

HTR1B DRD5 HTR2A

4.72e-0534473CID000005406
Drugfluspirilene

HTR1B DRD5 HTR2A

4.72e-0534473CID000003396
Drugpargyline

HTR1B DRD5 HTR2A PHF21A

4.80e-0597474CID000004688
DrugMetoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Up 200; 5.8uM; MCF7; HT_HG-U133A

NEU3 CACNA1I PAICS MAP3K1 GUCY2D

5.39e-051984756106_UP
DrugAC1L1CXF

HTR1B DRD5 HTR2A

5.61e-0536473CID000002104
Drugmolindone

HTR1B DRD5 HTR2A

5.61e-0536473CID000023897
DrugAC1MHW5N

HTR1B DRD5 HTR2A

5.61e-0536473CID003058747
Drugiloperidone

HTR1B DRD5 HTR2A

5.61e-0536473CID000071360
Drugbenzotropine mesylate

HTR1B DRD5 HTR2A

6.10e-0537473CID000002344
Drugpromazine

HTR1B DRD5 HTR2A

6.10e-0537473CID000004926
DrugZuclopenthixol

DRD5 HTR2A

6.22e-056472DB01624
DrugSch-38548

DRD5 HTR2A

6.22e-056472CID000130519
Drug(125i)gti

HTR1B HTR2A

6.22e-056472CID000131670
Drugcarpipramine

HTR2A GSR

6.22e-056472CID000002580
DrugAC1L1I8U

HTR1B DRD5

6.22e-056472CID000055036
DrugNDO 008

HTR1B HTR2A

6.22e-056472CID000131001
Drugpiperazine hydrobromide

HTR1B HTR2A

6.22e-056472CID003014804
DrugBrAcTFMPP

HTR1B HTR2A

6.22e-056472CID000146887
DrugMethiothepin

HTR1B HTR2A

6.22e-056472ctd:D008719
Drug5,6-ADTN

HTR1B DRD5

6.22e-056472CID000037630
DrugHW-165

HTR1B DRD5

6.22e-056472CID000125677
Drugpipamperone

HTR1B DRD5 HTR2A

6.61e-0538473CID000004830
Drug3-methoxytyramine

TAAR1 HTR1B DRD5

6.61e-0538473CID000001669
DrugRX821002

TAAR1 HTR1B HTR2A

7.72e-0540473CID000108094
DrugNSC95090

HTR1B DRD5 HTR2A

7.72e-0540473CID000003251
Drugcarbidine

HTR1B HTR2A GSR

7.72e-0540473CID000065684
DrugSaphris

HTR1B DRD5 HTR2A

8.32e-0541473CID000163091
DrugN,N-dipropyl-5,6-ADTN

HTR1B DRD5

8.70e-057472CID000122167
DrugUH 242

HTR1B DRD5

8.70e-057472CID000125884
DrugLY215840

CACNA1I HTR2A

8.70e-057472CID000132049
Drug7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine

DRD5 HTR2A

8.70e-057472ctd:C409874
Drugnisoxetine

HTR1B DRD5 HTR2A

8.94e-0542473CID000004500
DrugSerotonin

TAAR1 HTR1B HTR2A GSR

9.96e-05117474ctd:D012701
DrugUH232

HTR1B DRD5

1.16e-048472CID005311190
DrugL-745,870

DRD5 HTR2A

1.16e-048472CID005311200
DrugDP-8OH-3CA

HTR1B DRD5

1.16e-048472CID000086131
DrugAC1L5AAF

HTR1B HTR2A

1.16e-048472CID000173615
Drugmedifoxamine

HTR1B HTR2A

1.16e-048472CID000036109
Drug5-methoxy-1-methyl-2-(n-propylamino)tetralin

HTR1B DRD5

1.16e-048472CID000122334
Drugavitriptan

HTR1B HTR2A

1.16e-048472CID000133081
DrugBW 737C

HTR1B DRD5

1.16e-048472CID000132241
DrugSB 216641

HTR1B HTR2A

1.16e-048472CID003292447
DrugS 14489

HTR1B HTR2A

1.16e-048472CID000182595
Drug5-fluoro-alpha-methyltryptamine

HTR1B HTR2A

1.16e-048472CID000012834
Drugamoxapine

HTR1B DRD5 HTR2A

1.18e-0446473CID000002170
Drugloxapine

HTR1B DRD5 HTR2A

1.18e-0446473CID000003964
Drugnomifensine

HTR1B DRD5 HTR2A

1.18e-0446473CID000004528
DiseaseSchizophreniform Disorders

HTR1B DRD5 HTR2A

1.19e-0614453C0036358
DiseasePsychosis, Brief Reactive

HTR1B DRD5 HTR2A

1.19e-0614453C0033958
DiseaseSchizoaffective Disorder

HTR1B DRD5 HTR2A

1.18e-0529453C0036337
DiseasePsychotic Disorders

HTR1B DRD5 HTR2A TRPM2

1.73e-05101454C0033975
Diseasearachidonate 15-lipoxygenase B measurement

NLRP12 GUCY2D

4.75e-057452EFO_0801391
DiseaseManic Disorder

DRD5 HTR2A TRPM2

1.76e-0471453C0024713
DiseaseManic

DRD5 HTR2A TRPM2

2.33e-0478453C0338831
Diseaseschizophrenia (is_implicated_in)

CACNA1I HTR2A PAICS

2.33e-0478453DOID:5419 (is_implicated_in)
Diseaseschizophrenia (biomarker_via_orthology)

HTR2A KDM5C

2.36e-0415452DOID:5419 (biomarker_via_orthology)
DiseaseDepression, Bipolar

DRD5 HTR2A TRPM2

2.42e-0479453C0005587
Diseaseischemia (biomarker_via_orthology)

GJB2 HTR1B

3.43e-0418452DOID:326 (biomarker_via_orthology)
Diseaseattention deficit hyperactivity disorder (is_implicated_in)

HTR1B DRD5

4.25e-0420452DOID:1094 (is_implicated_in)
DiseaseAutosomal Dominant Parkinsonism

GSR LRRK2

8.38e-0428452C0752098
DiseaseAutosomal Dominant Juvenile Parkinson Disease

GSR LRRK2

8.38e-0428452C0752097
DiseaseParkinsonism, Experimental

GSR LRRK2

8.38e-0428452C0752101
DiseaseAutosomal Recessive Parkinsonism

GSR LRRK2

8.38e-0428452C0752100
DiseaseFamilial Juvenile Parkinsonism

GSR LRRK2

8.38e-0428452C0752104
DiseaseRamsay Hunt Paralysis Syndrome

GSR LRRK2

8.38e-0428452C0242423
DiseasePARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE

GSR LRRK2

8.38e-0428452C1868675
DiseaseParkinsonism, Juvenile

GSR LRRK2

9.63e-0430452C0752105
DiseaseParkinsonian Disorders

GSR LRRK2

9.63e-0430452C0242422
DiseasePapillary Renal Cell Carcinoma

NLRP12 KDM5C LRRK2

9.90e-04128453C1306837
DiseaseRenal Cell Carcinoma

NLRP12 KDM5C LRRK2

9.90e-04128453C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

NLRP12 KDM5C LRRK2

9.90e-04128453C1266043
DiseaseChromophobe Renal Cell Carcinoma

NLRP12 KDM5C LRRK2

9.90e-04128453C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

NLRP12 KDM5C LRRK2

9.90e-04128453C1266044
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

NLRP12 KDM5C LRRK2

1.50e-03148453C0279702

Protein segments in the cluster

PeptideGeneStartEntry
PCEECIVWLLLKEPM

CA3

201

P07451
CWLPFFIISLVMPIC

HTR1B

326

P28222
FIISLVMPICKDACW

HTR1B

331

P28222
TCVNVGCVPKKVMWN

GSR

101

P00390
WCPFFITNIMAVICK

HTR2A

336

P28223
GMIWFIVPISCVICN

CDS2

221

O95674
FSMQRLVKCNAWPCP

GJB2

161

P29033
VCCWLPFFILNCMVP

DRD5

306

P21918
VCCLQPRFWKEMSPF

IRF1-AS1

66

Q8N8D9
LPVKWMAPESIFNCV

KIT

831

P10721
APVECILLMKQCWAE

GUCY2D

776

Q02846
PFCEKVDVWSLGCVM

HIPK4

191

Q8NE63
VCCANTKVNWPMFPE

KY

556

Q8NBH2
MPIAQPCNIFDCPKW

ADAMTSL1

426

Q8N6G6
LKPWVCCAPQGDMIY

COPRS

141

Q9NQ92
TIPKGMWICPRCQDQ

PHF21A

521

Q96BD5
CAPWPMVEKLIKQCL

LRRK2

2101

Q5S007
GIQMVPISWCEMQCP

EXOSC1

161

Q9Y3B2
LAILSCFCPMWPVNI

PRRT2

271

Q7Z6L0
VCNPWFECVSMLVIL

CACNA1I

76

Q9P0X4
PPECLQLMKQCWAEA

GUCY2F

781

P51841
WSAQPICIKFCDMPV

CFHR4

386

Q92496
MVQLLNPCWCPTELV

DHDH

246

Q9UQ10
GCAIIEMACAKPPWN

MAP3K1

1436

Q13233
QICCDKPVLRDMNPW

IER5

306

Q5VY09
PPEEMQWFCPKCANK

TAF3

901

Q5VWG9
CWQKAGIVPMEFAEC

TIGD6

371

Q17RP2
MLAEWEANPLICPVC

RPAIN

126

Q86UA6
QCKEWQVLMCGFPFL

TMEM120A

301

Q9BXJ8
RMVPEDIKPCCNWDA

MOV10

586

Q9HCE1
DPNRVVCPICSAMPW

RNF166

176

Q96A37
SRCCEVLKVMVQAWP

PRAMEF19

46

Q5SWL8
CEVLKVMVQAWPFPC

PRAMEF22

51

A3QJZ6
RWFCMQKCVSLVPGV

RPTOR

276

Q8N122
TMNPCPVWEQKSGCV

NEU3

86

Q9UQ49
MLFCVALWPVQCALK

RNF223

206

E7ERA6
PVIPAMWLEDQVCFL

SPG11

1591

Q96JI7
FIAPQCEMIPIEWVC

PAICS

86

P22234
MSPTQWDFPVELCCR

TRAPPC11

1

Q7Z392
LLMFCDQEFPILKCW

PIGX

171

Q8TBF5
PCKTGAWIVPAIMAC

TRPM3

1106

Q9HCF6
VLMVDFQPVPSWCEC

TRPM2

816

O94759
LWQQRPELSPVEMCC

UBE3D

176

Q7Z6J8
FFCCWGPAVILMIIK

TMEM116

146

Q8NCL8
LICWCPFFICTVMDP

TAAR1

261

Q96RJ0
WPRQCCVMNNLKEPL

UPK1B

186

O75841
IPKGVWRCPKCVMAE

KDM5C

361

P41229
PLFTMCFVPLVCWVV

NLRP12

396

P59046
WNKIMHDCMVQPPFC

NALCN

1391

Q8IZF0