Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	fatty acid amide hydrolase activity	FAAH FAAH2	2.24e-04	4	123	2	GO:0017064
GeneOntologyMolecularFunction	transcription factor binding	CDKN2A FLT3 NACA SALL4 STAT6 MED24 GFI1B NCOR1 ARNT WIZ NFYA TAL1 TAF1L FOXP3	2.25e-04	753	123	14	GO:0008134
GeneOntologyCellularComponent	transcription regulator complex	XBP1 SALL4 RFX5 STAT6 MED24 GFI1B NCOR1 ARNT SKOR2 NFYA SIX5 TAL1 TAF1L	4.62e-05	596	122	13	GO:0005667
GeneOntologyCellularComponent	nascent polypeptide-associated complex	NACA NACAD	3.34e-04	5	122	2	GO:0005854
Domain	Amidase_CS	FAAH FAAH2	4.16e-05	2	121	2	IPR020556
Domain	TMEM191C	TMEM191C TMEM191B	4.16e-05	2	121	2	PF15194
Domain	TMEM191B/C	TMEM191C TMEM191B	4.16e-05	2	121	2	IPR028186
Domain	Amidase	FAAH FAAH2	1.24e-04	3	121	2	IPR000120
Domain	-	FAAH FAAH2	1.24e-04	3	121	2	3.90.1300.10
Domain	AMIDASES	FAAH FAAH2	1.24e-04	3	121	2	PS00571
Domain	Amidase_dom	FAAH FAAH2	1.24e-04	3	121	2	IPR023631
Domain	Amidase	FAAH FAAH2	1.24e-04	3	121	2	PF01425
Domain	EGD2/NACA	NACA NACAD	1.24e-04	3	121	2	IPR016641
Domain	NUT	NUTM2A NUTM2B	4.11e-04	5	121	2	IPR024310
Domain	NAC	NACA NACAD	4.11e-04	5	121	2	SM01407
Domain	NUT_N	NUTM2A NUTM2B	4.11e-04	5	121	2	IPR024309
Domain	NUT	NUTM2A NUTM2B	4.11e-04	5	121	2	PF12881
Domain	Nas_poly-pep-assoc_cplx_dom	NACA NACAD	6.14e-04	6	121	2	IPR002715
Domain	NAC	NACA NACAD	6.14e-04	6	121	2	PF01849
Domain	NAC_AB	NACA NACAD	6.14e-04	6	121	2	PS51151
Pubmed	A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.	IL12A STAT6 ANKRD17 TAL1	6.30e-07	19	127	4	34360789
Pubmed	A census of human transcription factors: function, expression and evolution.	KLF11 HIVEP1 XBP1 RFX5 THAP1 STAT6 GFI1B ARNT SKOR2 TOX3 NFYA ZFHX2 SIX5 TAL1 FOXP3	1.23e-06	908	127	15	19274049
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	CDKN2A DIP2B LYRM9 XBP1 SIK3 NACAD SLC52A3 NUTM2E INTS2 NUTM2B USP42 NFYA MROH7 TRAPPC10 FBXO33 FHIP1A CRB2	2.95e-06	1242	127	17	30973865
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	HIVEP1 NBEA SIK3 ABCC6 USP6 NCOR1 INTS13 NFKBIB ANKRD17 ARHGAP45 LRRC41 RAVER1	4.14e-06	638	127	12	31182584
Pubmed	The plasticity of regulatory T cell function.	IL12A TNFRSF10A FOXP3	5.60e-06	10	127	3	22013112
Pubmed	IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.	IL12A STAT6 FOXP3	5.60e-06	10	127	3	21364747
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	HIVEP1 RNF40 RFX5 MED24 NCOR1 WIZ INTS13 RAVER1	6.81e-06	268	127	8	33640491
Pubmed	Mechanisms underlying antigen-specific tolerance of stable and convertible Th17 cells during suppression of autoimmune diabetes.	IL12A FOXP3	1.32e-05	2	127	2	22751698
Pubmed	The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development.	XBP1 ERN2	1.32e-05	2	127	2	35727638
Pubmed	Promoter methylation of p16 and EDNRB gene in leukemia patients in Taiwan.	CDKN2A EDNRB	1.32e-05	2	127	2	18551992
Pubmed	The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.	STAT6 NCOR1	1.32e-05	2	127	2	29343442
Pubmed	p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice.	CDKN2A TAL1	1.32e-05	2	127	2	16407836
Pubmed	Lineage-restricted regulation of the murine SCL/TAL-1 promoter.	EDNRB TAL1	1.32e-05	2	127	2	7632958
Pubmed	Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.	CDKN2A SALL4	1.32e-05	2	127	2	34417458
Pubmed	Polystyrene nanoplastics aggravates lipopolysaccharide-induced apoptosis in mouse kidney cells by regulating IRE1/XBP1 endoplasmic reticulum stress pathway via oxidative stress.	XBP1 ERN2	1.32e-05	2	127	2	36370432
Pubmed	Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming.	STAT6 FOXP3	1.32e-05	2	127	2	26895644
Pubmed	Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.	FAAH FAAH2	1.32e-05	2	127	2	19095868
Pubmed	IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2.	STAT6 FOXP3	1.32e-05	2	127	2	23960232
Pubmed	Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns.	GFI1B TAL1	1.32e-05	2	127	2	24395799
Pubmed	Mouse hepatitis virus infection activates the Ire1/XBP1 pathway of the unfolded protein response.	XBP1 ERN2	1.32e-05	2	127	2	17037520
Pubmed	Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity.	XBP1 ERN2	1.32e-05	2	127	2	35105890
Pubmed	Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.	XBP1 STAT6	1.32e-05	2	127	2	12612580
Pubmed	Integrated Genomic and Immunophenotypic Classification of Pancreatic Cancer Reveals Three Distinct Subtypes with Prognostic/Predictive Significance.	CDKN2A FOXP3	1.32e-05	2	127	2	29661773
Pubmed	Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children.	STAT6 FOXP3	1.32e-05	2	127	2	23297791
Pubmed	Role of misfolded N-CoR mediated transcriptional deregulation of Flt3 in acute monocytic leukemia (AML)-M5 subtype.	FLT3 NCOR1	1.32e-05	2	127	2	22514634
Pubmed	XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.	XBP1 ERN2	1.32e-05	2	127	2	30973754
Pubmed	N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.	MALT1 N4BP1	1.32e-05	2	127	2	31133753
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	KLF11 HIVEP1 THAP1 GFI1B USP6 NCOR1 RNF220 CLEC4F NUTM2B DZIP3 SIX5	1.52e-05	608	127	11	16713569
Pubmed	Human transcription factor protein interaction networks.	CDKN2A HIVEP1 NACA RFX5 MED24 NCOR1 ARNT WIZ NFKBIB NFYA ANKRD17 SIX5 N4BP1 TAL1 TAF1L SFN RAVER1	1.84e-05	1429	127	17	35140242
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DIP2B FNDC3B NRDC NACA SIK3 SMC2 ARNT ANKRD17 PLCB3 LRRC41 RAVER1	2.80e-05	650	127	11	38777146
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	DIP2B HIVEP1 XBP1 TNFRSF10A RFX5 STAT6 USP6 MALT1 RNF220 SLC12A4 INTS13 TRAPPC10 LRRC41	3.58e-05	925	127	13	28986522
Pubmed	Circulating Levels of IL-35 and Gene Expression of FoxP3 in Coronary Artery Disease: Is There Any Interplay Between Them and 25-Hydroxyvitamin D3?	IL12A FOXP3	3.96e-05	3	127	2	29739077
Pubmed	Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.	XBP1 ERN2	3.96e-05	3	127	2	29511123
Pubmed	Flt3 ligand expands CD4+ FoxP3+ regulatory T cells in human subjects.	FLT3 FOXP3	3.96e-05	3	127	2	23124877
Pubmed	FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.	TAL1 FOXP3	3.96e-05	3	127	2	26686090
Pubmed	The inhibitory cytokine IL-35 contributes to regulatory T-cell function.	IL12A FOXP3	3.96e-05	3	127	2	18033300
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	3.96e-05	3	127	2	26542179
Pubmed	In vivo analysis of dendritic cell development and homeostasis.	FLT3 FOXP3	3.96e-05	3	127	2	19286519
Pubmed	Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF.	CDKN2A SFN	3.96e-05	3	127	2	18806827
Pubmed	Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.	CDKN2A FOXP3	3.96e-05	3	127	2	26378075
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2A NUTM2B	3.96e-05	3	127	2	22456610
Pubmed	Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.	CDKN2A FOXP3	3.96e-05	3	127	2	27183622
Pubmed	Clinicopathologic Characteristics of Breast Cancer According to the Infiltrating Immune Cell Subtypes.	STAT6 FOXP3	3.96e-05	3	127	2	32580398
Pubmed	Promoter-associated DNA methylation & expression profiling of genes (FLT 3, EPB41L3 & SFN) in patients with oral squamous cell carcinoma in the Khasi & Jaintia population of Meghalaya, India.	FLT3 SFN	3.96e-05	3	127	2	32048621
Pubmed	Lack of XBP-1 impedes murine cytomegalovirus gene expression.	XBP1 ERN2	3.96e-05	3	127	2	25333725
Pubmed	Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells.	CD74 FOXP3	3.96e-05	3	127	2	17869133
Pubmed	Type-1 immunity drives early lethality in scurfy mice.	STAT6 FOXP3	3.96e-05	3	127	2	22740092
Pubmed	IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts.	XBP1 ERN2	3.96e-05	3	127	2	31888027
Pubmed	MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression.	IL12A STAT6	3.96e-05	3	127	2	19342679
Pubmed	Diminished circulating concentration of interleukin-35 in Helicobacter pylori-infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients.	IL12A FOXP3	3.96e-05	3	127	2	29938865
Pubmed	STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.	STAT6 FOXP3	3.96e-05	3	127	2	18400747
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	KLF11 HIVEP1 XBP1 SALL4 RFX5 GFI1B NCOR1 PRR14 ARNT WIZ TOX3 NFYA	4.28e-05	808	127	12	20412781
Pubmed	Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells.	SLC16A1 FOXP3	7.90e-05	4	127	2	38417442
Pubmed	An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo.	STAT6 FOXP3	7.90e-05	4	127	2	20944002
Pubmed	Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.	FLT3 FOXP3	7.90e-05	4	127	2	19667061
Pubmed	Translocation t(8;14)(q24;q11) with concurrent PTEN alterations and deletions of STIL/TAL1 and CDKN2A/B in a pediatric case of acute T-lymphoblastic leukemia: A genetic profile associated with adverse prognosis.	CDKN2A TAL1	7.90e-05	4	127	2	27759908
Pubmed	Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP.	XBP1 FOXP3	7.90e-05	4	127	2	21085187
Pubmed	CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.	MALT1 FOXP3	7.90e-05	4	127	2	19454668
Pubmed	Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells.	XBP1 ERN2	7.90e-05	4	127	2	24242955
Pubmed	Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.	STAT6 FOXP3	7.90e-05	4	127	2	24038092
Pubmed	Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice.	CD74 FOXP3	7.90e-05	4	127	2	31653839
Pubmed	Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs.	IL12A FOXP3	7.90e-05	4	127	2	21220560
Pubmed	Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation.	STAT6 FOXP3	7.90e-05	4	127	2	24190658
Pubmed	p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.	CDKN2A TAL1	7.90e-05	4	127	2	17507663
Pubmed	Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival.	XBP1 ERN2	7.90e-05	4	127	2	28459443
Pubmed	Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.	CDKN2A FLT3	7.90e-05	4	127	2	18485879
Pubmed	Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.	XBP1 ERN2	7.90e-05	4	127	2	28082357
Pubmed	Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner.	IL12A FOXP3	7.90e-05	4	127	2	19414764
Pubmed	Affinity for self antigen selects Treg cells with distinct functional properties.	CD74 FOXP3	7.90e-05	4	127	2	27478940
Pubmed	Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.	IL12A FOXP3	7.90e-05	4	127	2	23704211
Pubmed	Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.	CDKN2A TNFRSF10A SFN	7.98e-05	23	127	3	30858352
Pubmed	Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.	IL12A FOXP3	1.31e-04	5	127	2	26745371
Pubmed	Normalization of obesity-associated insulin resistance through immunotherapy.	STAT6 FOXP3	1.31e-04	5	127	2	19633657
Pubmed	CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.	IL12A FOXP3	1.31e-04	5	127	2	21867928
Pubmed	Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.	FLT3 FOXP3	1.31e-04	5	127	2	26903243
Pubmed	Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.	MALT1 FOXP3	1.31e-04	5	127	2	31138793
Pubmed	Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.	CDKN2A NCOR1	1.31e-04	5	127	2	15729358
Pubmed	Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis.	USP6 NFKBIB	1.31e-04	5	127	2	22081069
Pubmed	Interleukin-27-Producing CD4(+) T Cells Regulate Protective Immunity during Malaria Parasite Infection.	IL12A FOXP3	1.31e-04	5	127	2	26968425
Pubmed	Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice.	IL12A ARNT	1.31e-04	5	127	2	11937300
Pubmed	The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis.	STAT6 GFI1B	1.31e-04	5	127	2	31980480
Pubmed	IL-35-mediated induction of a potent regulatory T cell population.	IL12A FOXP3	1.31e-04	5	127	2	20953201
Pubmed	Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.	IL12A STAT6 NFKBIB	1.62e-04	29	127	3	20716621
Pubmed	Control of developmentally primed erythroid genes by combinatorial co-repressor actions.	GFI1B NCOR1 TAL1	1.80e-04	30	127	3	26593974
Pubmed	Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells.	FLT3 FOXP3	1.97e-04	6	127	2	27166946
Pubmed	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.	XBP1 ERN2	1.97e-04	6	127	2	28743992
Pubmed	IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.	XBP1 ERN2	1.97e-04	6	127	2	26106220
Pubmed	TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.	STAT6 FOXP3	1.97e-04	6	127	2	22544395
Pubmed	14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF).	CDKN2A SFN	1.97e-04	6	127	2	19166854
Pubmed	Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.	ARNT FOXP3	1.97e-04	6	127	2	19286559
Pubmed	Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.	STAT6 GFI1B	1.97e-04	6	127	2	26847546
Pubmed	Interleukin-35 Limits Anti-Tumor Immunity.	IL12A FOXP3	1.97e-04	6	127	2	26872697
Pubmed	Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates.	IL12A FOXP3	1.97e-04	6	127	2	21723158
Pubmed	Stage-specific expression patterns of ER stress-related molecules in mice molars: Implications for tooth development.	XBP1 ERN2	1.97e-04	6	127	2	32758541
Pubmed	Imaging the emergence and natural progression of spontaneous autoimmune diabetes.	FLT3 FOXP3	1.97e-04	6	127	2	28839093
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MAN2A2 SZT2 NBL1 TMEM187 RNF40 SLC52A3 NCOR1 WIZ SLC12A4 TULP4 MCM3AP ENTPD2 HELZ2	2.10e-04	1105	127	13	35748872
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	HIVEP1 NACAD STAT6 NCOR1 SIX5 PRDM14	2.23e-04	233	127	6	37704626
Pubmed	Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells.	NLRP6 FOXP3	2.75e-04	7	127	2	29069606
Pubmed	Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4.	CDKN2A TAL1	2.75e-04	7	127	2	11813303
Pubmed	Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.	CDKN2A FLT3	2.75e-04	7	127	2	19144660
Interaction	RGS12 interactions	NBEA WIZ KIF14 PLCB3 SFN	6.67e-06	45	119	5	int:RGS12
Coexpression	GSE9037_CTRL_VS_LPS_1H_STIM_BMDM_DN	TENT4A ERN2 TTLL8 RFX5 SLC30A6 HHAT HELZ2 RAVER1	6.16e-06	200	127	8	M5801
Coexpression	HOEBEKE_LYMPHOID_STEM_CELL_UP	PGGHG TENT4A NACA MCM3AP SCN3A ARHGAP45	7.92e-06	97	127	6	M14698
Computational	Genes in the cancer module 277.	TENT4A SLC16A1 NFYA ANKRD17 RAVER1	2.74e-05	55	70	5	MODULE_277
Disease	L2 Acute Lymphoblastic Leukemia	CDKN2A FLT3 ARNT TAL1 PRDM14	2.03e-06	50	122	5	C0023453
Disease	Childhood Acute Lymphoblastic Leukemia	CDKN2A FLT3 ARNT TAL1 PRDM14	2.48e-06	52	122	5	C0023452
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	CDKN2A FLT3 ARNT TAL1 PRDM14	5.50e-06	61	122	5	C1961102
Disease	eosinophil count	CDKN2A DIP2B HIVEP1 TENT4A SIK3 ERN2 NACAD FAAH STAT6 MED24 GFI1B MALT1 HELZ2 PLCB3 N4BP1 ARHGAP45 TRIM48	1.36e-04	1488	122	17	EFO_0004842
Disease	Malignant neoplasm of breast	BOC CDKN2A FNDC3B RCCD1 XBP1 CFP SIK3 FAAH EDNRB NCOR1 TOX3 MROH7 CD74 FOXP3	1.46e-04	1074	122	14	C0006142
Disease	Endometrial Stromal Sarcoma	NUTM2A NUTM2B	1.68e-04	5	122	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	2.52e-04	6	122	2	C0334488
Disease	obsolete_Fms-related tyrosine kinase 3 ligand measurement	FLT3 NLRP6	3.51e-04	7	122	2	EFO_0010594
Disease	duodenal ulcer	FLT3 FSCN3 TTLL8	4.46e-04	36	122	3	EFO_0004607
Disease	LEUKEMIA, ACUTE LYMPHOBLASTIC	FLT3 TAL1	4.67e-04	8	122	2	613065
Disease	Acute lymphoid leukemia	FLT3 TAL1	4.67e-04	8	122	2	cv:C0023449
Disease	Squamous cell carcinoma of esophagus	CDKN2A SALL4 SLC52A3 SFN	6.62e-04	95	122	4	C0279626
Disease	Colorectal Carcinoma	BOC GALNS F5 ABCC6 CAPN10 GFI1B ARNT INTS13 MCM3AP NPAP1	6.88e-04	702	122	10	C0009402
Disease	Hypermetropia	TULP4 SLC16A1 HHAT KIF14	8.97e-04	103	122	4	HP_0000540
Disease	Hirschsprung's disease (implicated_via_orthology)	EDNRB MED24	1.09e-03	12	122	2	DOID:10487 (implicated_via_orthology)
Disease	acute myeloid leukemia (is_marker_for)	CDKN2A FLT3 GFI1B	1.11e-03	49	122	3	DOID:9119 (is_marker_for)
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	CDKN2A FLT3 TAL1	1.39e-03	53	122	3	C1961099
Disease	Diffuse Large B-Cell Lymphoma	CDKN2A STAT6 MALT1	1.55e-03	55	122	3	C0079744
Disease	acute lymphoblastic leukemia (is_implicated_in)	CDKN2A FLT3 TAL1	1.55e-03	55	122	3	DOID:9952 (is_implicated_in)
Disease	head and neck squamous cell carcinoma (is_implicated_in)	CDKN2A TNFRSF10A	1.72e-03	15	122	2	DOID:5520 (is_implicated_in)
Disease	asthma (biomarker_via_orthology)	EDNRB STAT6 FOXP3	1.89e-03	59	122	3	DOID:2841 (biomarker_via_orthology)
Disease	HbA1c measurement	CDKN2A DIP2B FNDC3B GALNS NLRP6 GFI1B PLCB3 FLRT1 ARHGAP45	2.01e-03	675	122	9	EFO_0004541
Disease	Dystonia, Limb	COL6A3 THAP1	2.21e-03	17	122	2	C0751093
Disease	Dystonia, Diurnal	COL6A3 THAP1	2.21e-03	17	122	2	C0393610
Disease	Dystonia, Paroxysmal	COL6A3 THAP1	2.48e-03	18	122	2	C0393588
Disease	neutrophil percentage of granulocytes	STAT6 GFI1B N4BP1 ARHGAP45 SFN	2.63e-03	228	122	5	EFO_0007994
Disease	Benign Neoplasm	CDKN2A TNFRSF10A ARHGAP45	2.84e-03	68	122	3	C0086692
Disease	Neoplasms	CDKN2A TNFRSF10A ARHGAP45	2.84e-03	68	122	3	C0027651
Disease	Malignant neoplasm of liver	CDKN2A IL12A NCOR1 TOX3	2.91e-03	142	122	4	C0345904
Disease	Liver neoplasms	CDKN2A IL12A NCOR1 TOX3	2.91e-03	142	122	4	C0023903
Disease	lymphocyte count	CDKN2A LYRM9 FLT3 HIVEP1 DNER XBP1 NBL1 TMEM187 NCOR1 PRR14 MCM3AP DZIP3 ARHGAP45 TRIM48	2.95e-03	1464	122	14	EFO_0004587
Disease	renal cell carcinoma (is_implicated_in)	CDKN2A TNFRSF10A ARNT	2.96e-03	69	122	3	DOID:4450 (is_implicated_in)
Disease	Malignant Glioma	CDKN2A IL12A XBP1	3.09e-03	70	122	3	C0555198
Disease	chemokine (C-C motif) ligand 27 measurement	F5 POM121L12 TAF1L	3.09e-03	70	122	3	EFO_0008082
Disease	mixed gliomas	CDKN2A IL12A XBP1	3.09e-03	70	122	3	C0259783
Disease	basophil count, eosinophil count	SIK3 STAT6 GFI1B N4BP1 ARHGAP45	3.33e-03	241	122	5	EFO_0004842, EFO_0005090
Disease	osteoarthritis (biomarker_via_orthology)	CDKN2A TNFRSF10A	3.38e-03	21	122	2	DOID:8398 (biomarker_via_orthology)
Disease	Precursor B-cell lymphoblastic leukemia	CDKN2A FLT3	3.38e-03	21	122	2	C1292769
Disease	in situ carcinoma (is_marker_for)	CDKN2A SFN	3.38e-03	21	122	2	DOID:8719 (is_marker_for)
Disease	free cholesterol to total lipids in large LDL percentage	TENT4A SIK3 FLRT1	3.61e-03	74	122	3	EFO_0022280
Disease	anxiety disorder (implicated_via_orthology)	NCOR1 SCN3A	3.71e-03	22	122	2	DOID:2030 (implicated_via_orthology)
Disease	transitional cell carcinoma (is_implicated_in)	CDKN2A SFN	3.71e-03	22	122	2	DOID:2671 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPQLGPTANLPLEMG	ARNT	481	P27540
LMQLRPPLSEPALAF	RNF40	151	O75150
SLLLLARPAQPCPMG	CPN2	11	P22792
EMPPTNPIRLGLALN	SFN	161	P31947
PPGVALPLESNLAFM	IBA57	236	Q5T440
APGAPAAVALVLMLL	CDKN2A	36	Q8N726
MQPPPSLCGRALVAL	EDNRB	1	P24530
RVNLPRVLSMPPVAG	CAPN10	431	Q9HC96
LAMPQALPLAAGPLP	ANKRD17	956	O75179
MLNLLPSPGLALVPD	MROH7	46	Q68CQ1
AVQPFPALLDLPMGS	RCCD1	286	A6NED2
PAMPLLNGPALSTAL	RAVER1	366	Q8IY67
AGAPPAAVPIINMIL	RFX5	371	P48382
LMAALAAVGPPNPRA	INTS13	101	Q9NVM9
PVLLGPPLLGRLNDM	SLC16A1	401	P53985
ADMPLTPNPVGRLAL	KIF14	76	Q15058
AAASIMPLGLLAAPP	GPR62	61	Q9BZJ7
NNVLQAPLPPMRLRG	ARHGAP45	1106	Q92619
LPTLPLVMVAPSGAR	FOXP3	71	Q9BZS1
MSLLGDPLQALPPSA	MALT1	1	Q9UDY8
MALARPGTPDPQALA	CRB2	1	Q5IJ48
NLARMAPAPEGPIVL	GFI1B	71	Q5VTD9
DLVGAMLSPLPQPRP	ERN2	756	Q76MJ5
LGFQLPQMDLPPLGA	MCM3AP	1666	O60318
MLLFLSVPQPRPPGA	FBXO33	1	Q7Z6M2
MFPGPLRGPAAQVLE	EXOC3-AS1	91	Q8N2X6
MLNLTNLIPADPPGL	ENTPD2	441	Q9Y5L3
TPLGSAMLRPNPILA	NFKBIB	276	Q15653
PLMFLLDTPGVLAPR	MTG1	196	Q9BT17
PEQPGVIPRALMDLL	KIF22	141	Q14807
LLQLMTSRPPATPAG	INTS2	411	Q9H0H0
VPGAPLPGRAILSMN	DIP2B	686	Q9P265
LARNLPVATPDPGMF	IL12A	21	P29459
AMLPSPLNVRLEAPA	PGGHG	56	Q32M88
MITEGAQAPRLLLPP	CFP	1	P27918
LVGAVLPAMLLAAPP	NBL1	6	P41271
PLLQGPDALAAPMSR	POM121L12	21	Q8N7R1
PAPPQGFIALSQVLM	GPR151	281	Q8TDV0
PSPEILMQQFLGRPL	DZIP3	956	Q86Y13
SLQAPAPLMAGLPTA	TENT4A	616	Q5XG87
VPALLMRLDGLTPPA	HHAT	306	Q5VTY9
VIPPALNPLACALRM	OR56B4	286	Q8NH76
VPLPSPQDLMGRILV	PLCB3	451	Q01970
MPALARDGGQLPLLV	FLT3	1	P36888
GAPQPPNILLLLMDD	GALNS	26	P34059
QQESRLAMGPPPLGL	LINC00482	151	Q8N8I6
LPLPVRNPMLAAALF	FHIP1A	996	Q05DH4
LVMGPLDNPNPILRC	HEATR5B	856	Q9P2D3
GNPEQMLRGQPALPR	BOC	436	Q9BWV1
LGNIPQMPSAPRLVR	FNDC3B	471	Q53EP0
GPAPRLSLQPDPMLV	CACNA1I	931	Q9P0X4
APLQGMLPGLLAPLR	COL6A3	611	P12111
APNSLLMANVILPGP	FSCN3	361	Q9NQT6
LPPQRLMALREPAAQ	IGHD	256	P01880
PRPVTEPLLLLSGMQ	FAAH2	41	Q6GMR7
LELTANAEGPPAMLP	MAN2A2	76	P49641
APALALPVARMQLPG	MAN2A2	1021	P49641
LPVARMQLPGPGLRS	MAN2A2	1026	P49641
MAPLPGAELVRRPLQ	LYRM9	1	A8MSI8
QGAVMLVLPQGALPP	KLF11	336	O14901
LTPMLAPALDLNAPG	FAAH	471	O00519
NNEQLPMLGRRPGAP	CD74	26	P04233
IRGPGLQMLPINPYR	FLRT1	586	Q9NZU1
LQTPALNMLFAPPGA	HELZ2	376	Q9BYK8
MQPRRAQAPGAQLLP	DNER	1	Q8NFT8
VMSRLPSALLPQAPG	SALL4	326	Q9UJQ4
GAPVPQMLAQPQRLL	NLRP6	261	P59044
MAAAALPPRPLLLLP	OLFML2A	1	Q68BL7
ALVFALGPAPTPEMR	INSL3	16	P51460
VPAIQRIPLPGAEML	NFYA	246	P23511
PLLLAAAPVVPVMAA	NUTM2A	246	Q8IVF1
PLLLAAAPVVPVMAA	NUTM2B	246	A6NNL0
PLLLAAAPVVPVMAA	NUTM2E	246	B1AL46
ALPMAPAPPLLAAAL	NRN1L	141	Q496H8
PLFPPLAAEVGMARA	SZT2	3246	Q5T011
MPQPLNLALRAGPIT	TRIM48	201	Q8IWZ4
VPRALVSALPGMEAP	SLC52A3	191	Q9NQ40
FRMAPPLLSPGLGLQ	PRDM14	71	Q9GZV8
MCRATLGLPLPPIVI	TMEM191B	1	P0C7N4
MCRATLGLPLPPIVI	TMEM191C	1	A6NGB0
NLSPALGQMPLSPDL	F5	1266	P12259
QLEMGFPRGAQPAPL	LRRC41	591	Q15345
PQDPILFPGSLRMNL	ABCC6	1346	O95255
GRMVQLSPPALAAPA	TAL1	116	P17542
DAQAMPRLLEPPVLA	TAF1L	506	Q8IZX4
PQGLAFAMLAAVPPI	SLC26A5	96	P58743
LPAGMINPSVPIRNI	NBEA	56	Q8NFP9
AQLRIMPLPAGGPSI	NCOR1	1791	O75376
QLNLTPMGLPRPIRL	PRR14	456	Q9BWN1
LLEQAMIGPSPNPLI	MED24	46	O75448
MLVSQVLPPAPGLAL	SIX5	571	Q8N196
ALPSMPRALAFQAPV	SIK3	396	Q9Y2K2
ELGLAPAPNPRRVMS	SHISA7	371	A6NL88
PAGQALPLMVPAQRG	XBP1	31	P17861
LPLMVPAQRGASPEA	XBP1	36	P17861
KLGPQVMAAARVPPR	WIZ	641	O95785
MAQALLVPPGPESFR	SCN3A	1	Q9NY46
LPNPLASPALMVLAS	RNF220	16	Q5VTB9
MLTALAPPALPGIPR	PROB1	1	E7EW31
GLAIRKTPMLPARNP	NPAP1	91	Q9NZP6
ARLVLLNMPGPPRNS	SLC12A4	1036	Q9UP95
AMAPAAPKIPRLVQA	CLEC4F	26	Q8N1N0
VEMGRIIQNPPPLSL	TULP4	761	Q9NRJ4
ANGLPGKLMPAPLLS	USP42	696	Q9H9J4
RQLLASELPMGPGLP	TTLL8	786	A6PVC2
LLMGRPESPASAPLQ	ZFR2	566	Q9UPR6
MAAARLLPVPAGPQP	ZNF250	1	P15622
PRMLLVDRLPGLQGA	ZSWIM9	226	Q86XI8
PMIPQTLIGLLPNAL	ZFHX2	2386	Q9C0A1
PGRPARLDQLLDMPA	SPSB4	31	Q96A44
FLGAPAKPPLVRADM	STAT6	301	P42226
IGLLMPPLQTPVNLS	THAP1	116	Q9NVV9
AARPFPILAMPGRNK	NRDC	41	O43847
DPALGMPDVLLPFQA	TOX3	76	O15405
PAFLLGAGMSPPQRI	MARS2	321	Q96GW9
STLLPGANAMLAPPE	SMC2	1046	O95347
MAPPPARVHLGAFLA	TNFRSF10A	1	O00220
MASSPLPGPNDILLA	SKOR2	1	Q2VWA4
MDPRVSGILVQLPLP	MTHFD2L	136	Q9H903
IIPGLSSIFLPRMNP	SLC30A6	186	Q6NXT4
AEAPVAGLPAFLAMP	TMEM187	41	Q14656
ELLALQNDPPPGMTL	UBE2W	11	Q96B02
LPMPRLQALPAGQVF	TRAPPC10	1221	P48553
EKALLLPGQMRPPLA	HIVEP1	726	P15822
PQENRPSLFGMPLIV	USP6	891	P35125
QNMGPPTFLARPGLL	ZAR1L	36	A6NP61
MPGTVATLRFQLLPP	TMEM198	1	Q66K66
ANDPMIPAALLPFQG	NACAD	301	O15069
ISPAALALASPMIAP	NACA	111	E9PAV3
QPLLSALPNVGMFDP	N4BP1	781	O75113