Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type endopeptidase activator activity	NLRP1 CARD8 NLRP3	5.47e-06	5	165	3	GO:0140608
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	3.92e-05	9	165	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	1.65e-04	14	165	3	GO:0072379
GeneOntologyCellularComponent	Z disc	FLNB FLNC ANK1 STUB1 SPTAN1 OBSCN NOS1AP	2.00e-04	151	165	7	GO:0030018
GeneOntologyCellularComponent	I band	FLNB FLNC ANK1 STUB1 SPTAN1 OBSCN NOS1AP	3.57e-04	166	165	7	GO:0031674
GeneOntologyCellularComponent	canonical inflammasome complex	NLRP1 CARD8 NLRP3	3.61e-04	18	165	3	GO:0061702
GeneOntologyCellularComponent	axolemma	ANK1 CNTNAP2 ROBO1	5.79e-04	21	165	3	GO:0030673
GeneOntologyCellularComponent	main axon	ANK1 SPTAN1 CNTNAP2 ROBO1 LRRC7	7.01e-04	89	165	5	GO:0044304
Domain	Ig-like_fold	FLNB COL6A3 FLNC COL7A1 OBSCN LINGO2 PTPRU TGM6 KIRREL2 NOMO1 PTPRK NOMO2 PLXNA4 PKHD1 ROBO1 RIMBP3C ZPBP2 KIR2DS5 KIR3DL1 NOMO3 EPHA4	1.14e-06	706	165	21	IPR013783
Domain	-	FLNB COL6A3 FLNC COL7A1 OBSCN LINGO2 PTPRU TGM6 KIRREL2 NOMO1 PTPRK NOMO2 PLXNA4 PKHD1 ROBO1 RIMBP3C ZPBP2 KIR3DL1 NOMO3 EPHA4	1.70e-06	663	165	20	2.60.40.10
Domain	DUF2012	NOMO1 NOMO2 NOMO3	2.69e-06	4	165	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	2.69e-06	4	165	3	IPR019008
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	3.67e-05	8	165	3	IPR013784
Domain	FN3	COL6A3 FLNC COL7A1 OBSCN PTPRU PTPRK ROBO1 RIMBP3C EPHA4	4.01e-05	185	165	9	SM00060
Domain	FIIND	NLRP1 CARD8	7.76e-05	2	165	2	PF13553
Domain	FIIND_dom	NLRP1 CARD8	7.76e-05	2	165	2	IPR025307
Domain	FN3_dom	COL6A3 FLNC COL7A1 OBSCN PTPRU PTPRK ROBO1 RIMBP3C EPHA4	1.03e-04	209	165	9	IPR003961
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	1.81e-04	13	165	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	1.81e-04	13	165	3	2.60.40.1120
Domain	FN3	COL6A3 COL7A1 OBSCN PTPRU PTPRK ROBO1 RIMBP3C EPHA4	3.98e-04	199	165	8	PS50853
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	4.20e-04	17	165	3	IPR008969
Domain	DUF1908	MAST1 MAST3	4.60e-04	4	165	2	PF08926
Domain	MA_Ser/Thr_Kinase_dom	MAST1 MAST3	4.60e-04	4	165	2	IPR015022
Domain	MAST_pre-PK_dom	MAST1 MAST3	4.60e-04	4	165	2	IPR023142
Domain	-	MAST1 MAST3	4.60e-04	4	165	2	1.20.1480.20
Domain	Pkinase_C	RPS6KA5 STK38 MAST1 MAST3	5.06e-04	42	165	4	PF00433
Domain	ConA-like_dom	FAT4 PTPRU LMAN1L PTPRK CNTNAP2 SEL1L3 TRIM47 NEURL4	7.47e-04	219	165	8	IPR013320
Domain	HEAT	MROH1 NCAPD2 GCN1 HTT	8.44e-04	48	165	4	PF02985
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA6C ENGASE FLNC CRYBG2 KMT2B SZT2 ARHGAP26 INTS1 OBSCN LAMC3 SLC10A3 MROH1 KLHL36 PIK3CD NCAPD2 HELZ2 USP7 OGDHL PYGB PC GCN1 HTT	2.11e-08	1105	168	22	35748872
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	1.11e-07	3	168	3	36011023
Pubmed	Genetic variation in the inflammasome and atopic dermatitis susceptibility.	NLRP1 CARD8 NLRP3	1.11e-07	3	168	3	23563199
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	1.11e-07	3	168	3	25576386
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	COL6A3 FLNC STUB1 SPTAN1 EVI5 PTPN11 NCAPD2 USP7 GCN1 SLC39A7	2.07e-07	231	168	10	36597993
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SHANK1 SNAPIN FLNB FGFR1OP2 ACTR8 STUB1 SPTAN1 PSMD7 ZNFX1 LRP1B TRAPPC1 STAB1 PTPRK NOMO2 TPP1 VPS35L USP7 MAST1 ROBO1 PC TOP1 EXOC4	2.87e-07	1285	168	22	35914814
Pubmed	Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.	DYNC2H1 OBSCN RNF213	4.41e-07	4	168	3	26147384
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	4.41e-07	4	168	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	4.41e-07	4	168	3	9267806
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNB DNAJC13 PDE4D ZNFX1 NCAPD2 CNTNAP2 ANKRD17 GCN1 NEURL4	6.71e-07	202	168	9	33005030
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	FLNB FLNC SPTAN1 NOMO1 PTPN11 NOMO2 HELZ2 USP7 GCN1 NOMO3 HTT	1.03e-06	344	168	11	30333137
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SHANK1 TPP2 FLNB FLNC DNAJC13 PDE4D ARHGAP26 SPTAN1 ZNFX1 TRAPPC1 HSPA12A PLXNA4 USP7 MAST1 OGDHL PYGB LRRC7 FH PC TOP1 SLC39A7 EXOC4	1.71e-06	1431	168	22	37142655
Pubmed	Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection.	NLRP1 CARD8 NLRP3	2.19e-06	6	168	3	22227487
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	SHANK1 FLNB FGFR1OP2 LETMD1 SPTAN1 PSMD7 ZNFX1 TRIM29 LRP1B HSPA12A VIPAS39 CNTNAP2 USP7 PYGB LRRC7 PC GCN1 SLC39A7 NOS1AP	2.88e-06	1139	168	19	36417873
Pubmed	Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.	NLRP1 ATP10A CARD8 NLRP3	2.95e-06	21	168	4	36332009
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FLNB SIN3B FAT4 APPBP2 KMT2B ANK1 CENPE INTS1 OBSCN PIDD1 RNF213 ARHGAP9 PLXNA4 PKHD1 LRRC7	3.22e-06	736	168	15	29676528
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TPP2 DNAJC13 SPTAN1 RNF213 PSMD7 SIX4 PTPRU RBM20 HSPA12A PTPN11 VIPAS39 PTPRK USP7 ROBO1 PC GCN1 NEURL4 NOS1AP	3.63e-06	1049	168	18	27880917
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	FLNB FLNC PDE4D SPTAN1 OBSCN PTPN11 MROH1 CNTNAP2 ANKRD17 FH GCN1 NEURL4 EXOC4	4.02e-06	564	168	13	21565611
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	FLNB FLNC SPTAN1 PSMD7 NOMO1 FGD5 FH NOMO3	4.49e-06	191	168	8	33762435
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	6.09e-06	8	168	3	15257293
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO1 NOMO2 NOMO3	9.10e-06	9	168	3	36261522
Pubmed	Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.	DNAAF3 DNAI1 DNAH9	1.78e-05	11	168	3	24421334
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO1 NOMO2 NOMO3	1.78e-05	11	168	3	32820719
Pubmed	Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.	RNF213 NLRP3 TRIM47	1.78e-05	11	168	3	31999304
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPP2 FLNB FLNC SPTAN1 INTS1 NCAPD2 HELZ2 USP7 ANKRD17 PYGB FH GCN1 TOP1	1.90e-05	653	168	13	22586326
Pubmed	Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres.	ANK1 OBSCN	2.32e-05	2	168	2	19002483
Pubmed	CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.	NLRP1 CARD8	2.32e-05	2	168	2	22087307
Pubmed	Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population.	NLRP1 NLRP3	2.32e-05	2	168	2	29850521
Pubmed	The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.	NLRP1 NLRP3	2.32e-05	2	168	2	26939933
Pubmed	Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.	NLRP1 NLRP3	2.32e-05	2	168	2	17164409
Pubmed	Polymorphisms in CARD8 and NLRP3 are associated with extrapulmonary TB and poor clinical outcome in active TB in Ethiopia.	CARD8 NLRP3	2.32e-05	2	168	2	30816317
Pubmed	Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil.	NLRP1 NLRP3	2.32e-05	2	168	2	20370570
Pubmed	Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome.	CARD8 NLRP3	2.32e-05	2	168	2	24098386
Pubmed	Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.	RPS6KA5 HTT	2.32e-05	2	168	2	18029446
Pubmed	NLRP1 and NLRP3 inflammasomes mediate LPS/ATP‑induced pyroptosis in knee osteoarthritis.	NLRP1 NLRP3	2.32e-05	2	168	2	29393464
Pubmed	Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms.	CARD8 NLRP3	2.32e-05	2	168	2	21621776
Pubmed	Tripping the wire: sensing of viral protease activity by CARD8 and NLRP1 inflammasomes.	NLRP1 CARD8	2.32e-05	2	168	2	37311351
Pubmed	Obscurin is a ligand for small ankyrin 1 in skeletal muscle.	ANK1 OBSCN	2.32e-05	2	168	2	12631729
Pubmed	PI3K regulates the activation of NLRP3 inflammasome in atherosclerosis through part-dependent AKT signaling pathway.	NLRP3 PIK3CD	2.32e-05	2	168	2	34162771
Pubmed	A 3'UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection.	NLRP1 NLRP3	2.32e-05	2	168	2	20502346
Pubmed	Caspase-1 inflammasomes in infection and inflammation.	NLRP1 NLRP3	2.32e-05	2	168	2	17442855
Pubmed	A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.	FLNB FLNC	2.32e-05	2	168	2	9694715
Pubmed	Inflammasomes: guardians of cytosolic sanctity.	NLRP1 NLRP3	2.32e-05	2	168	2	19120479
Pubmed	Associations of NLRP3 and CARD8 gene polymorphisms with alcohol dependence and commonly related psychiatric disorders: a preliminary study.	CARD8 NLRP3	2.32e-05	2	168	2	34587665
Pubmed	NLRP3 p.Q705K and CARD8 p.C10X single nucleotide polymorphisms are not associated with susceptibility to rheumatoid arthritis: a meta-analysis.	CARD8 NLRP3	2.32e-05	2	168	2	28185410
Pubmed	Screening and clinical significance of lymph node metastasis-related genes within esophagogastric junction adenocarcinoma.	LRP1B CDK6	2.32e-05	2	168	2	34152098
Pubmed	Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project).	CARD8 NLRP3	2.32e-05	2	168	2	18263599
Pubmed	Mapping the binding site on small ankyrin 1 for obscurin.	ANK1 OBSCN	2.32e-05	2	168	2	17720975
Pubmed	The NLRP1 and CARD8 inflammasomes detect reductive stress.	NLRP1 CARD8	2.32e-05	2	168	2	36649710
Pubmed	Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.	NLRP1 CARD8	2.32e-05	2	168	2	36649711
Pubmed	Sensing pathogens and danger signals by the inflammasome.	NLRP1 NLRP3	2.32e-05	2	168	2	19223160
Pubmed	CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction.	CARD8 NLRP3	2.32e-05	2	168	2	24517500
Pubmed	Inflammasome: Its role in traumatic brain and spinal cord injury.	NLRP1 NLRP3	2.32e-05	2	168	2	29150951
Pubmed	The role of NLRP1 and NLRP3 inflammasomes in the etiopathogeneses of pityriasis lichenoides chronica and mycosis fungoides: an immunohistochemical study.	NLRP1 NLRP3	2.32e-05	2	168	2	35776169
Pubmed	Neuroinflammation in Alzheimer's Disease: Focus on NLRP1 and NLRP3 Inflammasomes.	NLRP1 NLRP3	2.32e-05	2	168	2	34530705
Pubmed	A novel FLNC frameshift and an OBSCN variant in a family with distal muscular dystrophy.	FLNC OBSCN	2.32e-05	2	168	2	29073160
Pubmed	CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.	CENPB CENPE	2.32e-05	2	168	2	2022189
Pubmed	Conformational Changes in the Cytoplasmic Region of KIR3DL1 upon Interaction with SHP-2.	PTPN11 KIR3DL1	2.32e-05	2	168	2	30773397
Pubmed	The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease.	NLRP1 NLRP3	2.32e-05	2	168	2	21245836
Pubmed	Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes.	KIRREL2 LRRC7	2.32e-05	2	168	2	16741999
Pubmed	Different Actions of Intracellular Zinc Transporters ZIP7 and ZIP13 Are Essential for Dermal Development.	SLC39A13 SLC39A7	2.32e-05	2	168	2	31412620
Pubmed	The limits of promiscuity: isoform-specific dimerization of filamins.	FLNB FLNC	2.32e-05	2	168	2	12525170
Pubmed	Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients.	CARD8 NLRP3	2.32e-05	2	168	2	29230505
Pubmed	Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.	USP7 HTT	2.32e-05	2	168	2	33170804
Pubmed	Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.	NLRP1 CARD8	2.32e-05	2	168	2	33420028
Pubmed	Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.	NLRP1 CARD8	2.32e-05	2	168	2	33420033
Pubmed	Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease.	CARD8 NLRP3	2.32e-05	2	168	2	20182451
Pubmed	Combined polymorphisms in genes encoding the inflammasome components NLRP3 and CARD8 confer risk of ischemic stroke in men.	CARD8 NLRP3	2.32e-05	2	168	2	32689633
Pubmed	The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.	NLRP1 NLRP3	2.32e-05	2	168	2	25681332
Pubmed	Deregulated NLRP3 and NLRP1 inflammasomes and their correlations with disease activity in systemic lupus erythematosus.	NLRP1 NLRP3	2.32e-05	2	168	2	24334646
Pubmed	Phosphorylation of ankyrin down-regulates its cooperative interaction with spectrin and protein 3.	ANK1 SPTAN1	2.32e-05	2	168	2	2970468
Pubmed	Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii.	NLRP1 NLRP3	2.32e-05	2	168	2	24549849
Pubmed	Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease.	CARD8 NLRP3	2.32e-05	2	168	2	29408806
Pubmed	Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations.	CARD8 NLRP3	2.32e-05	2	168	2	22128899
Pubmed	Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease.	NLRP1 NLRP3	2.32e-05	2	168	2	29528779
Pubmed	Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke.	NLRP1 NLRP3	2.32e-05	2	168	2	24008734
Pubmed	Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis.	NLRP1 CARD8	2.32e-05	2	168	2	23053059
Pubmed	Association of NLRP3 and CARD8 Inflammasome Polymorphisms With Aseptic Loosening After Primary Total Hip Arthroplasty.	CARD8 NLRP3	2.32e-05	2	168	2	31529732
Pubmed	Association between NLRP3 rs10754558 and CARD8 rs2043211 Variants and Susceptibility to Chronic Kidney Disease.	CARD8 NLRP3	2.32e-05	2	168	2	36835594
Pubmed	Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma.	NLRP1 NLRP3	2.32e-05	2	168	2	22524199
Pubmed	Association of CARD8 Activating Polymorphism With Bone Erosion in Cholesteatoma Patients.	CARD8 NLRP3	2.32e-05	2	168	2	32396255
Pubmed	The role of NLRP3 and CARD8 polymorphisms in the risk of rheumatoid arthritis: A meta-analysis of genetic association studies.	CARD8 NLRP3	2.32e-05	2	168	2	37712526
Pubmed	Nod-like receptor protein 3 and nod-like receptor protein 1 inflammasome activation in the hippocampal region of postmortem methamphetamine chronic user.	NLRP1 NLRP3	2.32e-05	2	168	2	31663353
Pubmed	An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.	TPP2 FLNB FLNC PDE4D SPTAN1 NOMO1 USP7 FH GCN1 TOP1	2.55e-05	397	168	10	21319273
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SIN3B ARHGEF28 DYNC2H1 RNF213 ZNF623 ATP10A HELZ2 DDHD2 NEURL4 MAST3 EXOC4	3.05e-05	493	168	11	15368895
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	FLNB SIN3B SPTAN1 STK38 ANKRD17 ROBO1 GCN1 CDK6	3.73e-05	256	168	8	33397691
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	FLNB SIN3B DNAJC13 KMT2B RBM20 ANKRD17 PC GCN1 SLC39A7 EXOC4	3.94e-05	418	168	10	34709266
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	DNAJC13 STUB1 SZT2 DYNC2H1 PSMD7 PARS2 NOMO1 NOMO2 NCAPD2 TIMM29 PC NOMO3	4.22e-05	606	168	12	36538041
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	DNAJC13 GALC PDE4D ARHGAP26 CAPG PSMD7 TRIM29 ZNF71 MRPS2 HELZ2 USP7 ANKRD17 GCN1	6.13e-05	732	168	13	34732716
Pubmed	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.	ARHGEF28 RPS6KA5 LINGO2 CNTNAP2	6.13e-05	44	168	4	20200978
Pubmed	Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease.	TOP1 HTT	6.94e-05	3	168	2	28007908
Pubmed	Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin.	SHANK1 SPTAN1	6.94e-05	3	168	2	11509555
Pubmed	Language development and disorders: Possible genes and environment interactions.	CNTNAP2 ROBO1	6.94e-05	3	168	2	30077386
Pubmed	The corticofugal neuron-associated genes ROBO1, SRGAP1, and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development.	SRGAP1 ROBO1	6.94e-05	3	168	2	21060114
Pubmed	Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.	FLNB FLNC	6.94e-05	3	168	2	12393796
Pubmed	Expression of inflammasomes NLRP1, NLRP3 and AIM2 in different pathologic classification of lupus nephritis.	NLRP1 NLRP3	6.94e-05	3	168	2	31694740
Pubmed	Pathogenic variants of DYNC2H1, KIAA0556, and PTPN11 associated with hypothalamic hamartoma.	DYNC2H1 PTPN11	6.94e-05	3	168	2	31197031
Pubmed	PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.	PTPN11 PIK3CD	6.94e-05	3	168	2	24553178
Pubmed	Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.	CARD8 NLRP3	6.94e-05	3	168	2	19319132
Pubmed	Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.	FLNB FLNC	6.94e-05	3	168	2	11153914
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	STARD13 ARHGAP26 ARHGAP9 SRGAP1	2.95e-04	50	116	4	721
GeneFamily	Fibronectin type III domain containing	COL7A1 OBSCN PTPRU PTPRK ROBO1 EPHA4	5.82e-04	160	116	6	555
Coexpression	ZHONG_PFC_C3_ASTROCYTE	SEMA6C SIN3B TMEM151B OBSCN PTPRU PLXNA4 USP7 MAST1 ZFTA LRRC7 GCN1 UNC79 MAST3	1.29e-06	389	166	13	M39102
Coexpression	GSE22886_IGG_IGA_MEMORY_BCELL_VS_BLOOD_PLASMA_CELL_UP	FLNB COL6A3 PDE4D DYNC2H1 SPTAN1 CAPG NLRP3 PIK3CD PCDH9	5.30e-06	199	166	9	M4444
Coexpression	IBRAHIM_NRF2_DOWN	SEMA6C ENGASE TRIB2 PIDD1 PIGQ PHKG2 OGDHL ROBO1	1.23e-05	168	166	8	M42513
Coexpression	ZHONG_PFC_C1_NEUROD1_POS_EXCITATORY_NEURON	ARL4D PTPRK CNTNAP2 PCDH9	2.08e-05	26	166	4	M39088
Coexpression	MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP	PIDD1 NOMO1 DNAI1 NOMO2 SLC39A7 NOMO3 EXOC4 CDK6	2.47e-05	185	166	8	MM1115
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBGABA	PDE4D ANK1 LRP1B ADCY2 PTPRK PIK3CD CNTNAP2 PLXNA4 MAST1 OGDHL ROBO1 LRRC7 UNC79 PCDH9 CCDC144A	4.37e-05	703	166	15	M39070
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 FAT4 ANK1 LAMC3 HIF3A PREX2 ARSF CNTNAP2 ROBO1 FGD5	4.64e-09	200	167	10	7e51715525fdb001b7042b2bfcb9de81ecb5e4ee
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FAT4 ANK1 LAMC3 HIF3A PREX2 ARSF CNTNAP2 ROBO1 FGD5	6.91e-08	200	167	9	75649534a98bc738fca62d071de0978dc61eb24f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 ANK1 OBSCN LRP1B PKHD1 ROBO1 DNAH9 UNC79	4.89e-07	184	167	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 ANK1 OBSCN LRP1B PKHD1 ROBO1 DNAH9 UNC79	4.89e-07	184	167	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 ANK1 OBSCN LRP1B PKHD1 ROBO1 DNAH9 UNC79	4.89e-07	184	167	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	FLNB FAT4 PDE4D ARHGEF28 PREX2 FGD5 NOS1AP EPHA4	5.52e-07	187	167	8	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE4D DYNC2H1 GRB14 LRP1B SLC12A3 PKHD1 OGDHL NOS1AP	5.75e-07	188	167	8	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLNB PDE4D DYNC2H1 GRB14 LRP1B SLC12A3 PKHD1 NOS1AP	5.99e-07	189	167	8	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 FAT4 LAMC3 ATP10A PREX2 SRGAP1 ROBO1 PCDH9	8.18e-07	197	167	8	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 FAT4 LAMC3 ARL4D PTPRK ROBO1 PCDH9 EPHA4	8.83e-07	199	167	8	a95aa72387c9558e0316898eaa9df4de8932af1b
ToppCell	facs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALC DYNC2H1 PKDREJ STAB1 DNAI1 HSPA12A NOS1AP	3.29e-06	167	167	7	961e722442d786ab15d1e490941d2be265a9057a
ToppCell	facs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALC DYNC2H1 PKDREJ STAB1 DNAI1 HSPA12A NOS1AP	3.29e-06	167	167	7	3760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 RPS6KA5 OR14I1 LRP1B PTPRK CDH9 NOS1AP	4.65e-06	176	167	7	0710689e66deba179b0a8038cdd56b4834984f12
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 RPS6KA5 OR14I1 LRP1B PTPRK CDH9 NOS1AP	5.01e-06	178	167	7	6f61490d79cd1727ed2d5cc673823dd4efdafac1
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 LAMC3 PREX2 ARSF ROBO1 FGD5 CDH9	5.20e-06	179	167	7	97ba67a856680f24846244c0b92c886cc0e79537
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 ANK1 GRB14 LAMC3 SCML4 ARSF SRGAP1	5.39e-06	180	167	7	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB TTPA STAB1 PLXNA4 FGD5 TRIM47 EPHA4	5.59e-06	181	167	7	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CA9 FAT4 ANK1 LAMC3 TTPA SEL1L3 ROBO1	5.59e-06	181	167	7	7846c7b33d1b89364c5a704edaa86520db731c89
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 RPS6KA5 OR14I1 LRP1B PTPRK PLXNA4 MAST3	5.80e-06	182	167	7	35b2a5625323bf0917214d3b82fafc4a8f5e75ff
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 RPS6KA5 OR14I1 LRP1B PTPRK PLXNA4 MAST3	6.23e-06	184	167	7	9a185e6ea86bbfbb48bfe88650a8c05ceba78d7f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 KCP PIK3CD CNTNAP2 PKHD1 ROBO1 CDH9	6.92e-06	187	167	7	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 PDE4D ANK1 TMEM151B ADCY2 CNTNAP2 UNC79	6.92e-06	187	167	7	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE4D ARHGEF28 GRB14 LRP1B PKHD1 OGDHL CDH9	6.92e-06	187	167	7	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLNB DYNC2H1 GRB14 LRP1B SLC12A3 PKHD1 NOS1AP	6.92e-06	187	167	7	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 LAMC3 ATP10A PREX2 FGD5 PCDH9 EPHA4	7.95e-06	191	167	7	b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 ANK1 LAMC3 PREX2 ARSF ROBO1 FGD5	8.22e-06	192	167	7	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D ARHGEF28 HIF3A PTPRK TBCK ROBO1 CDK6	8.22e-06	192	167	7	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	Control-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	RPS6KA5 LRP1B PREX2 NOMO1 NOMO2 NOMO3 EPHA4	8.22e-06	192	167	7	7e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 KCP PTPRU PIK3CD CNTNAP2 ROBO1 CDH9	8.50e-06	193	167	7	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1-L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 FAT4 LAMC3 TTPA CNTNAP2 SEL1L3 ROBO1	1.07e-05	200	167	7	2086024ce808b8796ed508a229b098eb02f8828a
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 FAT4 LAMC3 TTPA CNTNAP2 SEL1L3 ROBO1	1.07e-05	200	167	7	35951db6a4f442ac9e13f1b8cc5b4a33481f92c8
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CCDC184-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 FAT4 ANK1 HIF3A SCML4 CNTNAP2 FGD5	1.07e-05	200	167	7	140aff451cd58e1d544ee668e49e37e577f6f068
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CCDC184\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 FAT4 ANK1 HIF3A SCML4 CNTNAP2 FGD5	1.07e-05	200	167	7	85bfa7f4dd07a4d4a88330e88f5886fd1ecfdeeb
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CPNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	SPTAN1 SRGAP1 PLXNA4 LRRC7 KIF3C EPHA4 EXOC4	1.07e-05	200	167	7	71cbefbef4ae5bbb5f6e419914f4b3b3b5a5f9e3
ToppCell	LA-15._Ventricular_Cardiomyocyte_III\|LA / Chamber and Cluster_Paper	FLNB CRYBG2 KCP RBM20 DNAAF3 KIF3C	1.96e-05	147	167	6	8970eb6b82589f39439c61a57d999661ec8342de
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCP LRP1B ADCY2 CNTNAP2 PKHD1 DNAH9	3.16e-05	160	167	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCP LRP1B ADCY2 CNTNAP2 PKHD1 DNAH9	3.16e-05	160	167	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	356C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	FLNB PDE4D ZNF155 SLC12A3 SEL1L3 PCDH9	3.51e-05	163	167	6	ae9c5eb19657ea94b7f2357cbc8679acd697b8fe
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Cajal-Retzius\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	CRYBG2 PIDD1 LINGO2 TRIM29 CNTNAP2 FGD5	3.51e-05	163	167	6	c1484e4de8b10e2f5fb14a7c02b2a015ffe0305e
ToppCell	356C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FLNB ZNF155 SLC12A3 SEL1L3 LRRC7 PCDH9	3.63e-05	164	167	6	fed26f4ac36a2b0722bc7b9f91659c5e0cf4d53a
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SHANK1 SEMA6C TMEM151B SIX4 MAST1 UNC79	4.02e-05	167	167	6	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SHANK1 SEMA6C TMEM151B SIX4 MAST1 UNC79	4.02e-05	167	167	6	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	DNAAF3 PHKG2 NCAPD2 SCNN1D PRXL2C CDK6	4.29e-05	169	167	6	29db25e7c5f31d98a08a35d7ec5ade203242bc50
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related-Oligodendrocyte/OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	DNAAF3 PHKG2 NCAPD2 SCNN1D PRXL2C CDK6	4.29e-05	169	167	6	b1611e61f635f8f9b87250e026ad30999cbee041
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1B CNTNAP2 PLXNA4 PKHD1 DNAH9 UNC79	4.29e-05	169	167	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	NS-critical-LOC-Lymphoid-NK\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PDE4D LINGO2 ATP10A PLXNA4 KIR3DL1 EPHA4	4.58e-05	171	167	6	adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRB14 OR14I1 PTPRK CDH9 MAST3 EPHA4	5.05e-05	174	167	6	9cc7251661ea2b1565eef1dfb8cf6dec3ade13d4
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	ZNF155 RNF213 ARHGAP9 IFI35 ATP10A HELZ2	5.21e-05	175	167	6	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D175\|Adult / Lineage, Cell type, age group and donor	HIF3A LRP1B PREX2 NOMO2 PLXNA4 FGD5	5.21e-05	175	167	6	0a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	ZNF155 RNF213 ARHGAP9 IFI35 ATP10A HELZ2	5.21e-05	175	167	6	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	SIN3B DNAJC13 RNF213 TBCK HTT CDK6	5.55e-05	177	167	6	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	RNF213 ZNFX1 IFI35 HELZ2 DNAH9 TOP1	5.91e-05	179	167	6	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 RPS6KA5 PTPRK PLXNA4 CCDC144A NOS1AP	5.91e-05	179	167	6	747a32460b257fffca30527b56a74720eb9c12e4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 RPS6KA5 LRP1B PTPRK CDH9 CCDC144A	5.91e-05	179	167	6	1ac79c82c52fa95bb4e170ab20fec0f648db2134
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 OR14I1 LRP1B PTPRK CDH9 CCDC144A	5.91e-05	179	167	6	065a50952e8703fa07767beb6b73a090bf378ca6
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DYNC2H1 TMEM151B OBSCN ADCY2 PREX2 DNAI1	5.91e-05	179	167	6	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 RPS6KA5 LRP1B PTPRK CDH9 CCDC144A	6.28e-05	181	167	6	9de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 RPS6KA5 OR14I1 LRP1B PTPRK MAST3	6.48e-05	182	167	6	cc6f9d606a4f8717dc44928ceec2a257636043fd
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 LAMC3 PREX2 SCML4 FGD5 CDH9	6.48e-05	182	167	6	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPE B3GNT3 TRIM29 DNAAF3 HSPA12A NCAPD2	6.48e-05	182	167	6	39f9b3eb22293cc27c6e175702c77d1eeb24fdc9
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	FLNC OBSCN KCP RBM20 LCLAT1 PCDH9	6.48e-05	182	167	6	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 LAMC3 PREX2 ARSF ROBO1 FGD5	6.48e-05	182	167	6	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 LAMC3 PREX2 SCML4 ARSF FGD5	7.09e-05	185	167	6	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB RPS6KA5 HEXD STAB1 PIGQ EPHA4	7.09e-05	185	167	6	87151ab95530e70d61328b336518df58db584acb
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 ANK1 PREX2 SCML4 ARSF FGD5	7.09e-05	185	167	6	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 ANK1 LAMC3 ARSF ROBO1 FGD5	7.09e-05	185	167	6	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RFX6 LRP1B STAB1 SRGAP1 PKHD1 KDM7A	7.30e-05	186	167	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LINGO2 LRP1B CNTNAP2 ROBO1 PCDH9 CDH9	7.30e-05	186	167	6	8915436d09775f2828a7678af203b1082b36e21c
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SHANK1 CNTNAP2 MAST1 LRRC7 UNC79 NOS1AP	7.30e-05	186	167	6	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4D ANK1 TMEM151B ADCY2 CNTNAP2 UNC79	7.30e-05	186	167	6	d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK1 EFCAB5 KCP LAMC3 RBM20	7.33e-05	115	167	5	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK1 EFCAB5 KCP LAMC3 RBM20	7.33e-05	115	167	5	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHANK1 EFCAB5 KCP LAMC3 RBM20	7.33e-05	115	167	5	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FLNB ARHGEF28 ARHGAP26 PTPRK TBCK PKHD1	7.52e-05	187	167	6	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PREX2 PLXNA4 FGD5 PCDH9 CDH9 EPHA4	7.52e-05	187	167	6	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	RNF213 ZNFX1 IFI35 ATP10A HELZ2 TOP1	7.75e-05	188	167	6	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	DYNC2H1 GRB14 LRP1B SLC12A3 PKHD1 NOS1AP	7.75e-05	188	167	6	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	ASK454-Endothelial-Lymphatic\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	DPAGT1 DNAJC13 NLRP1 VPS35L CCT6B CDK6	7.98e-05	189	167	6	316c857dec9383823e09f966bca62d52d933b141
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DYNC2H1 GRB14 LRP1B SLC12A3 PKHD1 NOS1AP	7.98e-05	189	167	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D KCP LRP1B PKHD1 KDM7A NOS1AP	8.45e-05	191	167	6	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	GRB14 PREX2 NOMO1 NOMO2 NOMO3 EPHA4	8.45e-05	191	167	6	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EFCAB5 COL7A1 KCP PKHD1 PCDH9 NOS1AP	8.45e-05	191	167	6	9032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB FAT4 RPS6KA5 PREX2 FGD5 EPHA4	8.45e-05	191	167	6	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EFCAB5 COL7A1 KCP PKHD1 PCDH9 NOS1AP	8.45e-05	191	167	6	5717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ARHGEF28 CENPE GRB14 RFX6 SEL1L3 PKHD1	8.70e-05	192	167	6	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE4D GRB14 LRP1B PKHD1 OGDHL NOS1AP	8.70e-05	192	167	6	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 ANK1 LAMC3 PREX2 ROBO1 FGD5	8.70e-05	192	167	6	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D PTPRK PKHD1 ANKRD17 VPS13B EXOC4	8.70e-05	192	167	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PREX2 STAB1 HSPA12A SRGAP1 FGD5	8.95e-05	193	167	6	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 KCP PIK3CD CNTNAP2 ROBO1 CDH9	8.95e-05	193	167	6	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 KCP PIK3CD CNTNAP2 ROBO1 CDH9	8.95e-05	193	167	6	010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PREX2 STAB1 HSPA12A SRGAP1 FGD5	8.95e-05	193	167	6	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 PREX2 STAB1 HSPA12A SRGAP1 FGD5	8.95e-05	193	167	6	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CRYBG2 ARHGEF28 GRB14 RFX6 SEL1L3 PKHD1	8.95e-05	193	167	6	5f0eba7b1440beb891d94a288f7f18a4e13c3a88
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA6C COL6A3 FLNC TRIB2 LRP1B ADCY2	8.95e-05	193	167	6	e5016959f24370579a8770787e96869f264cf7b3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NLRP1 HIF3A PREX2 PLXNA4 FGD5 EPHA4	8.95e-05	193	167	6	0b328f725f6feba263783eaca60c142e80df90f3
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D ARHGEF28 HIF3A TBCK ROBO1 CDK6	8.95e-05	193	167	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	COL6A3 FAT4 HIF3A SRGAP1 CNTNAP2 ROBO1	8.95e-05	193	167	6	acad568621ed677031797b8c2e34dafea798d681
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANK1 KCP PTPRU ADCY2 CNTNAP2 ROBO1	8.95e-05	193	167	6	658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	RNF213 ZNFX1 IFI35 ATP10A SCML4 HELZ2	9.47e-05	195	167	6	b64d9e1a8834401b4dc501566546647754ae21fc
Drug	trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT_HG-U133A	COL7A1 CRYBG2 ARHGAP26 SPTAN1 NLRP1 ARL4D PHKG2 PIK3CD CNTNAP2 PCDH9 NOS1AP ZNF574	9.88e-09	182	166	12	7503_UP
Disease	myofibrillar myopathy 5 (implicated_via_orthology)	FLNB FLNC	8.95e-05	3	162	2	DOID:0080096 (implicated_via_orthology)
Disease	distal muscular dystrophy 4 (implicated_via_orthology)	FLNB FLNC	8.95e-05	3	162	2	DOID:0111190 (implicated_via_orthology)
Disease	waist circumference	TRIB2 ARHGAP26 GRB14 LINGO2 SLC39A13 DNAAF3 PTPRK KLHL36 CNTNAP2 PKHD1	1.38e-04	429	162	10	EFO_0004342
Disease	JUVENILE MYELOMONOCYTIC LEUKEMIA	ARHGAP26 PTPN11	1.78e-04	4	162	2	607785
Disease	Juvenile myelomonocytic leukemia	ARHGAP26 PTPN11	1.78e-04	4	162	2	cv:C0349639
Disease	Metastatic melanoma	STK38 MAST1 EPHA4 CDK6	2.24e-04	54	162	4	C0278883
Disease	Malignant neoplasm of breast	DPAGT1 FLNB COL7A1 ANK1 DYNC2H1 SPTAN1 OBSCN SIX4 TRIM29 PKDREJ ROBO1 LRRC7 FGD5 DNAH9 TOP1 VPS13B	2.95e-04	1074	162	16	C0006142
Disease	Myelomonocytic leukemia	ARHGAP26 PTPN11	2.96e-04	5	162	2	C0027019
Disease	hypertension	COL6A3 ANK1 SZT2 KCP RNF213 LRRC7 FGD5 DDHD2	3.10e-04	307	162	8	EFO_0000537
Disease	cognitive function measurement	EFCAB5 PDE4D CYP2D7 SZT2 ARHGAP9 LAMC3 RFX6 LINGO2 LRP1B ADCY2 STAB1 SRGAP1 PLXNA4 PKHD1 MAST1 LRRC7 KIF3C CDH9 EXOC4	3.48e-04	1434	162	19	EFO_0008354
Disease	neutropenia, response to metamizole, Drug-induced agranulocytosis	STARD13 PTPRU	4.43e-04	6	162	2	EFO_0010971, HP_0012235, MONDO_0001475
Disease	alcohol consumption measurement	RPS6KA5 TNFSF13 LAMC3 RFX6 LINGO2 DPP3 GDF1 AK8 SLC39A13 PIGQ PHKG2 PTPRK PLXNA4 PKHD1 HTT EPHA4 ZNF574	5.03e-04	1242	162	17	EFO_0007878
Disease	juvenile myelomonocytic leukemia (is_implicated_in)	ARHGAP26 PTPN11	6.18e-04	7	162	2	DOID:0050458 (is_implicated_in)
Disease	cesarean section, Self-injurious behavior	DNAAF3 CDH9 EXOC4	7.17e-04	32	162	3	EFO_0009636, HP_0100716
Disease	stem Cell Growth Factor beta measurement	SHANK1 DNAAF3 CNTNAP2 PCDH9	7.86e-04	75	162	4	EFO_0008292
Disease	melanoma (implicated_via_orthology)	GALC TRAPPC1	8.21e-04	8	162	2	DOID:1909 (implicated_via_orthology)
Disease	Ataxias, Hereditary	TTPA TPP1	8.21e-04	8	162	2	C0004138
Disease	Disproportionate short stature	FLNB DYNC2H1 SLC39A13 PTPN11	8.68e-04	77	162	4	C0878659
Disease	Kartagener Syndrome	DNAAF3 DNAI1 DNAH9	9.34e-04	35	162	3	C0022521
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	DNAAF3 DNAI1 DNAH9	9.34e-04	35	162	3	C4551906
Disease	Polynesian Bronchiectasis	DNAAF3 DNAI1 DNAH9	9.34e-04	35	162	3	C4317124
Disease	choroid plexus volume measurement	CNTNAP2 PLXNA4	1.05e-03	9	162	2	EFO_0010293
Disease	lymphocyte count	DPAGT1 FLNB TRIB2 PDE4D ANK1 GRB14 HIF3A PREX2 ZNF71 SCML4 LMAN1L PIK3CD USP7 ZPBP2 DDHD2 NEURL4 HTT CDK6	1.18e-03	1464	162	18	EFO_0004587
Disease	neurodegenerative disease (implicated_via_orthology)	FAT4 PSMD7 SCNN1D OGDHL HTT	1.26e-03	145	162	5	DOID:1289 (implicated_via_orthology)
Disease	promotilin measurement	RFX6 EPHA4	1.31e-03	10	162	2	EFO_0801930
Disease	telomere length	ARHGEF28 ZNF596 USP7 SCNN1D PYGB ROBO1 CDH9	1.78e-03	313	162	7	EFO_0004505
Disease	Colorectal Carcinoma	SHANK1 DPAGT1 FLNC COL7A1 ZNF155 TNFSF13 OBSCN PTPRU PREX2 PKHD1 EXOC4	1.79e-03	702	162	11	C0009402
Disease	left ventricular systolic function measurement	FLNC OBSCN LRP1B	1.82e-03	44	162	3	EFO_0008206
Disease	diffusing capacity of the lung for carbon monoxide	TRIB2 LINGO2 LRP1B EPHA4	1.96e-03	96	162	4	EFO_0009369
Disease	Primary Ciliary Dyskinesia	DNAAF3 DNAI1 DNAH9	2.21e-03	47	162	3	C4551720
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	KMT2B ARHGAP26 TMEM151B KCP CDK6	2.53e-03	170	162	5	EFO_0000685, EFO_0007791, EFO_0007837
Disease	Kartagener syndrome (implicated_via_orthology)	DNAAF3 DNAI1	2.61e-03	14	162	2	DOID:0050144 (implicated_via_orthology)
Disease	lysophosphatidylcholine 15:0 measurement	LRP1B PKHD1	2.61e-03	14	162	2	EFO_0020941
Disease	trauma exposure measurement	ARHGEF28 LINGO2 LRP1B SCML4 SRGAP1	2.66e-03	172	162	5	EFO_0010703
Disease	Oral ulcer	PDE4D KCP NLRP3 ZPBP2	2.91e-03	107	162	4	HP_0000155
Disease	level of C-X-C motif chemokine 3 in blood serum	SEMA6C NOS1AP	3.00e-03	15	162	2	OBA_2041208
Disease	Situs ambiguus	GDF1 DNAH9	3.00e-03	15	162	2	C0266642
Disease	African Burkitt's lymphoma	CCT6B PC	3.00e-03	15	162	2	C0343640
Disease	Autosomal recessive primary microcephaly	CENPE CDK6	3.00e-03	15	162	2	cv:C3711387
Disease	RASopathy	ARHGAP26 PTPN11	3.00e-03	15	162	2	cv:C5555857
Disease	Burkitt Leukemia	CCT6B PC	3.00e-03	15	162	2	C4721444
Disease	Ciliopathies	DYNC2H1 GDF1 DNAAF3 PKHD1	3.22e-03	110	162	4	C4277690
Disease	asthma, response to diisocyanate	TRIB2 DYNC2H1 LRP1B PIK3CD PYGB EPHA4	3.28e-03	261	162	6	EFO_0006995, MONDO_0004979
Disease	p-cresol sulfate measurement	STARD13 EPHA4	3.42e-03	16	162	2	EFO_0010998
Disease	optic cup area measurement	FLNB TRIB2 HSPA12A	3.64e-03	56	162	3	EFO_0006940
Disease	cancer (implicated_via_orthology)	SIN3B HIF3A TRAPPC1 PIK3CD TOP1 CDK6	3.73e-03	268	162	6	DOID:162 (implicated_via_orthology)
Disease	response to radiation, Urinary retention	COL6A3 LRP1B	3.86e-03	17	162	2	GO_0009314, HP_0000016
Disease	plasma beta-amyloid 1-40 measurement	STARD13 DNAAF3	3.86e-03	17	162	2	EFO_0005659
Disease	Dystonia, Limb	COL6A3 KMT2B	3.86e-03	17	162	2	C0751093
Disease	Dystonia, Diurnal	COL6A3 KMT2B	3.86e-03	17	162	2	C0393610
Disease	urate measurement	COL7A1 DNAJC13 TRIM29 STAB1 PTPN11 PKHD1 PYGB DDHD2 PC TOP1 MAST3 EPHA4	4.00e-03	895	162	12	EFO_0004531
Disease	neuroticism measurement, cognitive function measurement	PTPRU LRP1B ADCY2 STAB1 PTPRK PCDH9 CDH9 MAST3 EXOC4	4.19e-03	566	162	9	EFO_0007660, EFO_0008354
Disease	Dystonia, Paroxysmal	COL6A3 KMT2B	4.33e-03	18	162	2	C0393588
Disease	response to mepolizumab, Glucocorticoid use measurement	HIF3A EPHA4	4.33e-03	18	162	2	EFO_0008459, EFO_0009942
Disease	aspartate aminotransferase measurement	FLNB DNAJC13 OBSCN RNF213 ARHGAP9 NLRP3 HSPA12A PTPN11 CNTNAP2 ROBO1 GCN1 CDK6	4.33e-03	904	162	12	EFO_0004736
Disease	amino acid measurement	FAT4 PDE4D ARHGEF28 ZNF596 GRB14 ARHGAP9 LINGO2 TGM6 KIF3C HTT	4.39e-03	678	162	10	EFO_0005134
Disease	Juvenile Myelomonocytic Leukemia	ARHGAP26 PTPN11	4.82e-03	19	162	2	C0349639

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLLQGNVRHSEHEFL	ARSF	431	P54793
LPHFQALHVVVIGLD	ARL4D	16	P49703
DISGLQDHEFQIRHP	ACTR8	356	Q9H981
PLHIAAREGHVETVL	ANK1	506	P16157
EPILQRRGHVESHDF	FAT4	4116	Q6V0I7
FAVLHGHIPVVQLLL	BTBD11	656	A6QL63
HAERAIGIITHILPE	APPBP2	356	Q92624
EVAVLRHLETFEHPN	CDK6	61	Q00534
RHLETFEHPNVVRLF	CDK6	66	Q00534
QPQHDVRLEDLGELH	CCDC144CP	71	Q8IYA2
HPIIIVGDDRGHIIS	DNAI1	641	Q9UI46
HVIILGDLNTAHRPI	APEX2	191	Q9UBZ4
HLAVVELLLAHGADP	ANKRD17	676	O75179
ERLHDQVSVELPHLG	ATP10A	716	O60312
VEGHRFPAEIHVVHL	CA9	241	Q16790
VRPLQAHELNDFHGV	RBM20	391	Q5T481
IERALPHHRVIEVGN	NOMO3	1026	P69849
HLAQIARPALFDQHV	RFX6	391	Q8HWS3
HLPSVAHLEDFQGLI	RIMBP3C	1536	A6NJZ7
LSGFEDVHLEPHLLI	ARHGEF28	1246	Q8N1W1
IERALPHHRVIEVGN	NOMO2	1026	Q5JPE7
PLEVEHVVGQGVLHR	OGFOD2	271	Q6N063
AHARQVLENIHFPLI	KLHL36	226	Q8N4N3
HAFEIPDNVRPGHLI	KDM7A	451	Q6ZMT4
SKQGLLHPHRIDIFE	LRP1B	4111	Q9NZR2
IQRGTHPAIHDILAL	LETMD1	221	Q6P1Q0
IPHFCGVQLDQRHLV	IL17REL	96	Q6ZVW7
ELLQPHVFRSEHQGA	INTS1	1916	Q8N201
IVGVPLELEQSTHRH	LRRC7	816	Q96NW7
PVGIEHHFLELDHIL	LMAN1L	416	Q9HAT1
RIFILAHFPHQVLAG	G6PC3	161	Q9BUM1
HVEELGVAGNIVRHI	GDF1	91	P27539
HLLQGDFPREIHFHV	LCLAT1	271	Q6UWP7
QFDHPNIIHLEGVVT	EPHA4	676	P54764
IHIPIFHGRIFQESF	KIR3DL1	66	P43629
LRGVIPNAFEHIFTH	KIF3C	116	O14782
PHHEFVALIGALLAI	DPAGT1	91	Q9H3H5
HIGISFIPREVGEHL	FLNB	1961	O75369
VLHGVPRDLDQAHLL	AK8	351	Q96MA6
PRIITENGDHHVVQL	PLXNA4	621	Q9HCM2
ILDGPELHDVLEIHF	IFI35	241	P80217
IRGHHVAQLDPLGIL	OGDHL	126	Q9ULD0
GLAPLHIQLVDAHEA	SLC10A3	141	P09131
HHVIQELPLDNTFVG	PCDH9	961	Q9HC56
IHDVDHPGVSNQFLI	PDE4D	501	Q08499
VEAVHLPHFVALQGG	NLRP1	1161	Q9C000
PFDGIHIVNHLIGDD	EVI5	721	O60447
IARIAQHLEHIDPTA	FAM214A	486	Q32MH5
GEGVFQSDLLLPHIH	FGD5	186	Q6ZNL6
IRFIPHENGVHSIDV	FLNC	2466	Q14315
IERALPHHRVIEVGN	NOMO1	1026	Q15155
LQIDHLVFVVHGIGP	DDHD2	211	O94830
DQVLELHPGAQRLHI	HEXD	131	Q8WVB3
HGQHLERLARELFPD	KDM4E	216	B2RXH2
PSFDVQVGLHELLGH	DPP3	441	Q9NY33
ELHIVGAQLRTIEPH	LINGO2	301	Q7L985
IPFLQQEVHEGTLVH	GCN1	391	Q92616
GIHHDAVIFLAEQLP	KMT2B	2466	Q9UMN6
HDVGVVHRDLKPENL	RPS6KA5	536	O75582
VDLTVHQIRLPEGHL	HSPA12A	321	O43301
NILPFDHTRVVLHDG	PTPN11	281	Q06124
LEHLRVSALVPFHNL	MROH1	951	Q8NDA8
LRQVAGHPHIITLID	PHKG2	81	P15735
PLADGVLSFIHHQII	MAST1	211	Q9Y2H9
FNHTLRLIGEHIDGV	KIR2DS5	66	Q14953
HTGQLHPAVRVADLL	PTPRU	866	Q92729
PAHFIGRLRHQESIE	OBSCN	3361	Q5VST9
LDASRHILEAPQHGL	FGFR1OP2	146	Q9NVK5
HVLERIHPLETEQAG	DYNC2H1	3101	Q8NCM8
DPHEINIFLPHEIRF	EFCAB5	1126	A4FU69
HPLLRFIQEIEHALG	EXOC4	501	Q96A65
LENVLPAHVAEHFLA	ADCY2	856	Q08462
FPIDDRVQSHILHLE	CENPB	561	P07199
VVIHLLGDEDPRVRH	HTT	911	P42858
KLHDRGAQVIHPQEF	DNAAF3	216	Q8N9W5
DIEEHLQRVGHFDPV	STUB1	256	Q9UNE7
HIAAAIEVHEVLLPG	FH	196	P07954
VGLEHLRVNHFVPEA	COL6A3	1721	P12111
LQPVLQVGEHDLHFV	CRYBG2	1341	Q8N1P7
AEIHLPHFISLQAGE	CARD8	246	Q9Y2G2
QPQHDVRLEDLGELH	CCDC144B	71	Q3MJ40
DHDPGRHLFVGQLIQ	B3GNT3	226	Q9Y2A9
QELALSEGALPRHLH	DNAJC13	601	O75165
LADGVLGFIHHQIVE	MAST3	206	O60307
AANGQHDLHIRPVEL	KIRREL2	81	Q6UWL6
LFEHLPHIGVERTIE	GRB14	151	Q14449
AVHLNTLLGERPVQH	CAPG	81	P40121
AAILHVADHVFLPQL	COL7A1	121	Q02388
NSDGVVRHELQHPII	CNTNAP2	141	Q9UHC6
HLSAQEIQPLFGEHR	ENGASE	426	Q8NFI3
AALAEAQDIHVHLIP	DNAH9	301	Q9NYC9
QPQHDVRLEDLGELH	CCDC144A	71	A2RUR9
LRIPLHNEDAFQHGI	NOS1AP	16	O75052
PVIFGHVQGHERSLL	HELZ2	2466	Q9BYK8
EDPGEHHFTLRQVLN	GALC	521	P54803
DSQQFHLVPVHLDRV	RNASE7	141	Q9H1E1
HGVGLVLRVEQQPHL	SCNN1D	466	P51172
LHEIPHEVGDFAILL	SLC39A13	256	Q96H72
HIPVFIRILDINDHA	CDH9	471	Q9ULB4
DHLGVIPRAIHDIFQ	CENPE	101	Q02224
LRPHATDDFNHGVVL	NEURL4	541	Q96JN8
LLSHVLELQPHGVAF	PIDD1	376	Q9HB75
GQLHPAIRVADLLQH	PTPRK	861	Q15262
VIHQFFRDIPHVLAL	OR14I1	171	A6ND48
LLDHPRHVEILGFSE	NLRP3	361	Q96P20
VPQLHGEVLLDDRTH	PARS2	401	Q7L3T8
PVGQVDRHIQLLVHG	SZT2	2151	Q5T011
EFLRPAVQQLDSHVH	SNAPIN	31	O95295
DLFPHLDDILQHVNG	STARD13	481	Q9Y3M8
DSIHQLGFIHRDIKP	STK38	201	Q15208
PHLEGAAFRDHQLLE	TRIM29	201	Q14134
AQEHRGHELVPLEQE	TRIM47	206	Q96LD4
LIQGLVLDHGARHPD	CCT6B	206	Q92526
EGTIIPHHILDFLEI	SEL1L3	996	Q68CR1
SGDPVFHIRLEERHQ	SRGAP1	196	Q7Z6B7
DDEFLHLPAHLRVVG	TIMM29	186	Q9BSF4
FPVLIVHRQEGCLGH	TMEM151B	536	Q8IW70
VHPLVLLSVVDHFNR	PSMD7	11	P51665
VELRGHTVILHAQPG	KCP	1306	Q6ZWJ8
DQHLRGHVIVLPDND	PKDREJ	1211	Q9NTG1
QLELIGHSIFDFIHP	HIF3A	121	Q9Y2N7
RIGHLADALVPVADH	PIGQ	301	Q9BRB3
HPNLHLLFDRPEEAV	ARHGAP26	736	Q9UNA1
PAVHQDFVQEHRLVL	SIX4	701	Q9UIU6
VSQLFHEHPDLIVGF	SIN3B	86	O75182
LAVRHLSLHIEPEEG	PKHD1	16	P08F94
LHTLNNIFEPHVAVR	MRPS2	196	Q9Y399
RAQFLDHEIDGSHLP	SHANK1	2116	Q9Y566
ILHHFRSIDPGLKED	NCAPD2	66	Q15021
EGHLILPTFNHLVIR	C15orf32	111	Q32M92
AVIHEVQHFGDIVPL	CYP2D7	376	A0A087X1C5
ILGPGNNIHFIHRDR	PRXL2C	181	Q7RTV5
DEFHRDLSHILGIPQ	RNF213	656	Q63HN8
TDLGVGPIRDVLHHI	TRAPPC1	86	Q9Y5R8
LRQHQRIHAGEKPFE	ZNF383	381	Q8NA42
REVGIKHQEIPFIQH	ZNF596	76	Q8TC21
VPDHPEHGVLFLVRE	VPS35L	786	Q7Z3J2
LLHEVPHEVGDFAIL	SLC39A7	356	Q92504
VLPEHHEAFNRLLGD	SPDYE4	101	A6NLX3
LLEPLEGDHVFRAVH	TRIB2	66	Q92519
HQALQAEIAGHEPRI	SPTAN1	826	Q13813
LLEVHQLVVHAGRQP	ZNF574	621	Q6ZN55
HLDHVAALFPGDVDR	PYGB	411	P11216
DVHFKPGQIRRHFIE	TPP2	651	P29144
HEVQEHFPEALARLL	PIK3CD	536	O00329
FRLGFHEVHILPDIN	SLC12A3	886	P55017
LREPHFVQALEHGDH	SEMA6C	221	Q9H3T2
ELLQHHGLVPQIEAA	STAB1	1146	Q9NY15
NVLHIRTIPGHEFLL	ARHGAP9	401	Q9BRR9
HRPEEGVHLGQALLE	PREX2	426	Q70Z35
RELGNAVLHLHNPTV	ROBO1	671	Q9Y6N7
GFHRVVEILHKNNAP	VIPAS39	406	Q9H9C1
GIVHRALSPHNILLD	TBCK	111	Q8TEA7
VRGIHLINEPVIFHA	TTPA	191	P49638
IDPVLHNLTELRHLG	TAS1R2	306	Q8TE23
HLILIGDHQQLRPSA	ZNFX1	1026	Q9P2E3
IEPDLVHHLTFQARE	VPS13B	2886	Q7Z7G8
GVRHPHIVHVFEFIE	TSSK6	66	Q9BXA6
FNLDLHQRVHTGERP	ZNF155	441	Q12901
LIEHQRIHTGERPFE	ZNF623	306	O75123
PFLLRIHQGEHFREV	USP7	1006	Q93009
LIQHQRFHIGVKPFE	ZNF71	341	Q9NQZ8
HAQIHVAEGRSLPDL	PC	346	P11498
SLRVEHINLHPELDG	TOP1	506	P11387
QALGPHVELFRKHEI	SCML4	361	Q8N228
ILHESHAVRLGPQEE	TGM6	546	O95932
VFHLHQGDILSVIIP	TNFSF13	216	O75888
SVEIPEHGLIHELFI	ZPBP2	191	Q6X784
HLDDIRAHVLEVHPG	ZFTA	296	C9JLR9
HVADHLIVILIGFPE	UNC79	2446	Q9P2D8
IRQAELLLPGAEFHH	TPP1	126	O14773
DAGHPREVELRFHLQ	LAMC3	596	Q9Y6N6