Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of basement membrane organization

LAMB2 PHLDB1

7.09e-0511242GO:0110011
GeneOntologyBiologicalProcessbasement membrane assembly

LAMB2 PHLDB1

8.50e-0512242GO:0070831
MousePhenoabnormal amacrine cell morphology

STK38 STK38L LAMB2

1.28e-0531213MP:0005240
MousePhenoincreased retina apoptosis

STK38 STK38L LAMB2

3.98e-0545213MP:0030005
MousePhenoabnormal retina apoptosis

STK38 STK38L LAMB2

1.04e-0462213MP:0006072
DomainPkinase_C

STK38 STK38L

1.03e-0337242IPR017892
DomainPkinase_C

STK38 STK38L

1.32e-0342242PF00433
DomainAGC-kinase_C

STK38 STK38L

2.34e-0356242IPR000961
DomainAGC_KINASE_CTER

STK38 STK38L

2.34e-0356242PS51285
DomainS_TK_X

STK38 STK38L

2.34e-0356242SM00133
DomainPH

ARHGAP10 PHLDB1 MPRIP

3.04e-03229243PF00169
DomainPH

ARHGAP10 PHLDB1 MPRIP

5.24e-03278243SM00233
DomainPH_DOMAIN

ARHGAP10 PHLDB1 MPRIP

5.29e-03279243PS50003
DomainPH_domain

ARHGAP10 PHLDB1 MPRIP

5.34e-03280243IPR001849
Domain-

ARHGAP10 PHLDB1 MPRIP

1.33e-023912432.30.29.30
DomainPH_dom-like

ARHGAP10 PHLDB1 MPRIP

1.67e-02426243IPR011993
Pubmed

NDR functions as a physiological YAP1 kinase in the intestinal epithelium.

STK38 STK38L

4.56e-07224225601544
Pubmed

Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein.

STK38 STK38L

4.56e-07224215037617
Pubmed

Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4.

STK38 STK38L

1.37e-06324223897809
Pubmed

Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.

STK38 STK38L

1.37e-06324221262772
Pubmed

HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.

STK38 STK38L

1.37e-06324215582665
Pubmed

NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.

STK38 STK38L

2.74e-06424219062280
Pubmed

Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.

STK38 STK38L

2.74e-06424215197186
Pubmed

Ndr kinases regulate retinal interneuron proliferation and homeostasis.

STK38 STK38L

4.56e-06524230135513
Pubmed

Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.

STK38 STK38L

4.56e-06524215067004
Pubmed

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.

TYRP1 TBX21

4.56e-06524231924474
Pubmed

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.

STK38 STK38L

6.83e-06624236446521
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

STK38 DYNC2H1 PHLDB1 ZFC3H1

7.91e-0618724426460568
Pubmed

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

STK38 STK38L

6.94e-051824220064376
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

RBM12B LAMB2 MPRIP

7.31e-0511824321078624
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

STK38 RBM12B DYNC2H1 KIFC2 PHLDB1

1.43e-0475424535906200
Pubmed

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.

STK38 STK38L TYRP1

1.67e-0415624326170170
Pubmed

SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation.

STK38 STK38L

4.64e-044624229969578
Pubmed

MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24.

STK38 STK38L

5.48e-045024224980433
Pubmed

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.

STK38 ARHGAP10

5.93e-045224230655611
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PHLDB1 MPRIP

1.40e-02206162682
CoexpressionGSE5455_HEALTHY_VS_TUMOR_BEARING_MOUSE_SPLEEN_MONOCYTE_DN

STK38 STK38L TBX21 ZFC3H1

3.04e-05199244M6576
Diseasechildhood onset asthma

TYRP1 EXD3 TBX21 ITPKA

8.29e-05334214MONDO_0005405
Diseaseglioma

STK38L PHLDB1

1.10e-0422212EFO_0005543
Diseasehearing loss

IL4I1 PHLDB1

1.04e-0367212EFO_0004238
Diseaserespiratory system disease

TBX21 ITPKA

4.74e-03145212EFO_0000684
DiseaseQT interval

LAMB2 ARHGAP10 ITPKA

6.15e-03534213EFO_0004682
DiseaseDisorder of eye

TYRP1 IMPG2

9.86e-03212212C0015397

Protein segments in the cluster

PeptideGeneStartEntry
DFRRPSEEDFRRPWE

RBM12B

586

Q8IXT5
FRHPREEDWRRPLEE

RBM12B

611

Q8IXT5
PFWEASRRALERDDF

KCNJ9

256

Q92806
PWFRERIRAHEAELE

ARHGAP10

16

A1A4S6
REGRSKTFDWAEFRP

MPRIP

536

Q6WCQ1
PLEFEFLWGSRAHRE

MAGEE2

246

Q8TD90
FEAPDSRNRWDRPLF

KTI12

216

Q96EK9
FRDRFPEAQWRERPD

COG8

31

Q96MW5
DFYRDLPWRPAEDGH

LAMB2

326

P55268
HRRPWEEGNREDGYL

ITPKA

431

P23677
RGEHLSPDHWLDLFR

DYNC2H1

1201

Q8NCM8
RYEHGRFWPFLRESD

HDAC10

196

Q969S8
DRLLFFWSDRRNPHE

EGLN1

361

Q9GZT9
GRHRRFRLDWVFPPD

KIFC2

441

Q96AC6
FLSFRRPFWREEHIE

IL4I1

356

Q96RQ9
PRRGEAHFDQDERWS

MMP28

211

Q9H239
RACRRPHAEPYEDFW

RTP5

531

Q14D33
FFEGVDWEHIRERPA

STK38

381

Q15208
PFFEGVDWEHIRERP

STK38L

381

Q9Y2H1
FRTFWDRLPGREEYH

IMPG2

121

Q9BZV3
HDGRDDREVWPLRFF

TYRP1

81

P17643
RPRRWAAHGASPEDF

PHLDB1

491

Q86UU1
PSFWERSHLALDRFR

ZFC3H1

131

O60293
WLGAPRDHSYEAEFR

TBX21

386

Q9UL17
LREEAWRGFAALDDP

EXD3

41

Q8N9H8