Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PNT	ETV7 ETV6	4.77e-04	11	56	2	PS51433
Domain	Pointed_dom	ETV7 ETV6	4.77e-04	11	56	2	IPR003118
Domain	SAM_PNT	ETV7 ETV6	4.77e-04	11	56	2	PF02198
Domain	SAM_PNT	ETV7 ETV6	4.77e-04	11	56	2	SM00251
Domain	ETS_DOMAIN_1	ETV7 ETV6	3.17e-03	28	56	2	PS00345
Domain	ETS_DOMAIN_2	ETV7 ETV6	3.17e-03	28	56	2	PS00346
Domain	ETS	ETV7 ETV6	3.17e-03	28	56	2	SM00413
Domain	Ets_dom	ETV7 ETV6	3.17e-03	28	56	2	IPR000418
Domain	ETS_DOMAIN_3	ETV7 ETV6	3.17e-03	28	56	2	PS50061
Domain	Ets	ETV7 ETV6	3.17e-03	28	56	2	PF00178
Domain	Sulfotransferase_dom	CHST15 NDST2	5.21e-03	36	56	2	IPR000863
Domain	Sulfotransfer_1	CHST15 NDST2	5.21e-03	36	56	2	PF00685
Pubmed	Genome-wide analysis of gene transcription in the hypothalamus.	IMPACT CNGA1 ITIH3	1.12e-06	13	56	3	15870395
Pubmed	Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6.	ETV7 ETV6	2.55e-06	2	56	2	11108721
Pubmed	Molecular diagnosis of putative Stargardt disease by capture next generation sequencing.	PROM1 ABCA4	2.55e-06	2	56	2	24763286
Pubmed	The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).	ETV7 ETV6	7.63e-06	3	56	2	12588862
Pubmed	CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.	PTPN6 PLCG1	1.52e-05	4	56	2	8627166
Pubmed	Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.	PTPN6 PLCG1	1.52e-05	4	56	2	27221712
Pubmed	Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31.	PTPN6 PLCG1	2.54e-05	5	56	2	10350061
Pubmed	Identification of the phosphotyrosine proteome from thrombin activated platelets.	P2RX6 ACVR1B	2.54e-05	5	56	2	12112843
Pubmed	Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice.	PROM1 CNGA1	3.80e-05	6	56	2	18654668
Pubmed	Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.	CHST15 NDST2	3.80e-05	6	56	2	19915053
Pubmed	TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia.	PTPN6 CLTCL1 TUBGCP3	4.04e-05	41	56	3	19786618
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	POLE SYNE2 TUBGCP3 ALDH9A1 ADD2	5.32e-05	251	56	5	29778605
Pubmed	Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.	PTPN6 PLCG1	9.10e-05	9	56	2	9045636
Pubmed	Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy.	PROM1 LATS1	9.10e-05	9	56	2	36283963
Pubmed	Fine specificity and molecular competition in SLAM family receptor signalling.	PTPN6 PLCG1	1.14e-04	10	56	2	24642916
Pubmed	Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.	PTPN6 PLCG1	1.14e-04	10	56	2	9632636
Pubmed	Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.	CLTCL1 HGS	1.39e-04	11	56	2	29604273
Pubmed	Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci.	PROM1 APCS	1.66e-04	12	56	2	12805272
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	PROM1 PTPN6 RNH1 JADE2 HGS APCS ALDH9A1 ENPEP	2.12e-04	1016	56	8	19056867
Pubmed	Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons.	HGS ETV6	2.29e-04	14	56	2	20844136
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	PROM1 ABCA4 CNGA1	3.09e-04	81	56	3	20301590
Pubmed	Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.	PTPN6 PLCG1	4.75e-04	20	56	2	31591574
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	PROM1 PTPN6 ABCA4 SYNE2	5.49e-04	233	56	4	32290105
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PCYOX1L GRTP1 JADE2 SIGIRR CLK2 TMEM212 PAK3 GRIK1 PLCG1	5.81e-04	1489	56	9	28611215
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	DOCK4 HGS PLCG1	6.24e-04	103	56	3	21706016
Pubmed	ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways.	FAR2 ALOXE3	7.46e-04	25	56	2	37660780
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	JADE2 SYNE2	1.08e-03	30	56	2	30480076
Pubmed	A human MAP kinase interactome.	PROM1 LATS1 JADE2 HGS PAK3	1.11e-03	486	56	5	20936779
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	PROM1 CLTCL1 RNH1 APCS ALDH9A1 ENPEP ITIH3	1.60e-03	1070	56	7	23533145
Cytoband	1q21-q23	INSRR APCS	1.13e-04	13	56	2	1q21-q23
Cytoband	4p15.32	PROM1 FAM200B	1.73e-04	16	56	2	4p15.32
Cytoband	15q25.2	BNC1 WDR73	1.28e-03	43	56	2	15q25.2
Cytoband	13q34	GRTP1 TUBGCP3	2.01e-03	54	56	2	13q34
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLA2G4F PLCG1	6.45e-04	19	36	2	832
GeneFamily	ETS transcription factor family	ETV7 ETV6	1.41e-03	28	36	2	534
GeneFamily	Sulfotransferases, membrane bound	CHST15 NDST2	2.46e-03	37	36	2	763
GeneFamily	Phospholipases	PLA2G4F PLCG1	3.16e-03	42	36	2	467
Coexpression	GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP	PROM1 JADE2 HGS ETV6 WDR73 GRIK1	3.36e-06	195	55	6	M9527
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BNC1 ABCA4 P2RX6 SYNE2 GRIK1	2.59e-06	173	56	5	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BNC1 ABCA4 P2RX6 SYNE2 GRIK1	2.59e-06	173	56	5	3725525b99a6011eda2ff5459b4fd2e1eab1f090
Disease	Stargardt disease	PROM1 ABCA4	1.02e-05	3	55	2	cv:C0271093
Disease	STARGARDT DISEASE 1 (disorder)	PROM1 ABCA4	3.40e-05	5	55	2	C1855465
Disease	Stargardt's disease	PROM1 ABCA4	5.09e-05	6	55	2	C0271093
Disease	kidney cancer (implicated_via_orthology)	LATS1 POLE	1.86e-04	11	55	2	DOID:263 (implicated_via_orthology)
Disease	Retinitis pigmentosa	PROM1 ABCA4 CNGA1	3.62e-04	74	55	3	cv:C0035334
Disease	metabolite measurement	SLC24A5 CLTCL1 SYNE2 ALDH9A1 FAM200B ENPEP	6.00e-04	560	55	6	EFO_0004725
Disease	eye color	SLC24A5 ETV6 ENPEP	6.42e-04	90	55	3	EFO_0003949
Disease	Disorder of eye	SLC24A5 PROM1 ABCA4 CNGA1	6.63e-04	212	55	4	C0015397
Disease	Retinitis Pigmentosa	PROM1 ABCA4 CNGA1	9.77e-04	104	55	3	C0035334
Disease	diabetes mellitus (implicated_via_orthology)	PROM1 INSRR	1.08e-03	26	55	2	DOID:9351 (implicated_via_orthology)
Disease	Cone-Rod Dystrophy 2	PROM1 ABCA4	1.34e-03	29	55	2	C3489532
Disease	level of Sphingomyelin (d38:1) in blood serum	SYNE2 NLRP1	1.44e-03	30	55	2	OBA_2045180

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLVYVRYAWQDDFLE	FAM200B	241	P0CF97
ARLDIDISWQCLEYY	ALDH9A1	106	P49189
DAAVYGLLAWYLDQV	ABCA4	846	P78363
LIYHVGDWLQERYEI	CLK2	151	P49760
ADIYALGLVYWEIAR	ACVR1B	401	P36896
AISRAILDLVLYYNW	GRIK1	156	P39086
LDWTLQDYIRGYVLQ	BNC1	131	Q01954
FYIGREDGYIDIWDL	DNAI3	731	Q8IWG1
YLEDIINYRWELEEG	CECR2	81	Q9BXF3
GEINSILLDYYLWDY	C9orf64	306	Q5T6V5
ADCRLLWDYVYQLLS	ETV6	336	P41212
RQLNWLEYIENYVLG	FAR2	426	Q96K12
VNYLDSYLVGDELWV	PAK3	341	O75914
LYDWGLRGYIVIEDL	APOO	166	Q9BUR5
ILAEADNEWVVRLYY	LATS1	756	O95835
DRWLRDYCASGLYIL	ENTPD8	396	Q5MY95
TELERGNIFLADYWI	ALOXE3	316	Q9BYJ1
RYDLDEIDAYWLELI	JADE2	136	Q9NQC1
VALLAYNRWYQDLDK	PCYOX1L	466	Q8NBM8
YLVAQYGEQRAWDLA	NLRP1	56	Q9C000
VLSFLYRWIYDGELE	TUBGCP3	426	Q96CW5
NWGLITYRETNLLYD	ENPEP	361	Q07075
AILDWDYYIERLGSA	POLE	1126	Q07864
LWGLLVEYLLYQEEN	PLA2G4F	461	Q68DD2
EIYIQNIGESILYLW	IMPACT	91	Q9P2X3
CELLVWYGDEYGQEL	PRDM9	351	Q9NQV7
YDVELIALIRANYWL	FKBP11	136	Q9NYL4
YTLLLYDELLEWSDR	DOCK4	1221	Q8N1I0
ADCRLLWDYVYQLLL	ETV7	221	Q9Y603
LWDYVYQLLLDTRYE	ETV7	226	Q9Y603
WLLDALVGRILPDYY	GRTP1	176	Q5TC63
TYYLVLWQRLAEDGD	INSRR	636	P14616
YLDEQRAVKYLWLAA	DELE1	366	Q14154
DLLLLYVDREAHFYW	P2RX6	356	O15547
YLLYAQLEEEWGLAR	XAB2	596	Q9HCS7
YEDVAIAAYLLILWE	TRMT44	331	Q8IYL2
LYQGYLNLLLWDLEN	TCP11X2	196	Q5H9J9
DYYENLGRALALWDK	SYNE2	1636	Q8WXH0
GNYIERLWAYLTIEQ	ITIH3	551	Q06033
RVLDTPYLLNEDWEY	PROM1	526	O43490
VLLWYQDAYGEVEIN	SIGIRR	146	Q6IA17
WALYEDEGVIRCYLE	NCKIPSD	401	Q9NZQ3
YRLLDLYGWAQLSDT	ADD2	141	P35612
YRTDEYQKWLLLVGI	CLTCL1	156	P53675
RLQVGLYAVYLLDWL	CHST15	451	Q7LFX5
DELQSDYLEYWLILD	CNGA1	186	P29973
LLLAYREWTQRYLGE	TMEM212	61	A6NML5
LLAAAVASDYWYILE	TMEM235	21	A6NFC5
ILDWQALNYEIRGYV	APCS	201	P02743
DIDPELARYLNRNYW	HGS	321	O14964
YADLRYHQDVLIEWL	VWA2	691	Q5GFL6
YDNQVYWYEGALLLL	SLC24A5	191	Q71RS6
YVNLDAWSRELLDRY	NDST2	146	P52849
QFLLDYQGELWAVDR	PLCG1	256	P19174
GCLLEQLVLYDIYWS	RNH1	426	P13489
DNGDLIREIWHYQYL	PTPN6	401	P29350
LRSLLWYDETLYAEL	TEX15	1716	Q9BXT5
DWLVESLRLYQDFYA	WDR73	6	Q6P4I2