Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionJUN kinase activity

MAPK8 MAPK10

3.84e-053722GO:0004705
GeneOntologyBiologicalProcessmitotic actomyosin contractile ring assembly

IQGAP3 IQGAP1

3.60e-053722GO:1903475
GeneOntologyBiologicalProcessmitotic actomyosin contractile ring assembly actin filament organization

IQGAP3 IQGAP1

3.60e-053722GO:1903479
GeneOntologyBiologicalProcessassembly of actomyosin apparatus involved in mitotic cytokinesis

IQGAP3 IQGAP1

3.60e-053722GO:1902407
GeneOntologyBiologicalProcessactomyosin contractile ring assembly actin filament organization

IQGAP3 IQGAP1

7.18e-054722GO:2000689
DomainCoronin

CORO1A CORO6 CORO1B

1.75e-067703IPR015505
DomainTrimer_CC

CORO1A CORO6 CORO1B

1.75e-067703IPR015049
DomainDUF1899

CORO1A CORO6 CORO1B

1.75e-067703IPR015048
DomainDUF1899

CORO1A CORO6 CORO1B

1.75e-067703SM01166
DomainTrimer_CC

CORO1A CORO6 CORO1B

1.75e-067703PF08954
DomainDUF1899

CORO1A CORO6 CORO1B

1.75e-067703PF08953
DomainRho_GTPase_activation_prot

ARHGAP42 GAPVD1 DEPDC1B IQGAP3 IQGAP1

1.97e-0588705IPR008936
DomainRasGAP

GAPVD1 IQGAP3 IQGAP1

2.22e-0515703PF00616
DomainRAS_GTPASE_ACTIV_1

GAPVD1 IQGAP3 IQGAP1

2.22e-0515703PS00509
DomainRAS_GTPASE_ACTIV_2

GAPVD1 IQGAP3 IQGAP1

2.22e-0515703PS50018
Domain-

GAPVD1 IQGAP3 IQGAP1

2.73e-05167031.10.506.10
DomainRasGAP_dom

GAPVD1 IQGAP3 IQGAP1

3.95e-0518703IPR001936
DomainRasGAP_C

IQGAP3 IQGAP1

4.14e-053702IPR000593
DomainRasGAP_C

IQGAP3 IQGAP1

4.14e-053702PF03836
DomainSUMO_chordates

SUMO3 SUMO2

4.14e-053702IPR027218
DomainSumo

SUMO3 SUMO2

8.27e-054702IPR033950
DomainRad60-SLD

SUMO3 SUMO2

1.37e-045702PF11976
DomainMAPK_JNK

MAPK8 MAPK10

1.37e-045702IPR008351
DomainRad60/SUMO-like_dom

SUMO3 SUMO2

1.37e-045702IPR022617
Domainubiquitin

SACS SUMO3 SUMO2

7.26e-0447703PF00240
DomainMAP_kinase_CS

MAPK8 MAPK10

8.92e-0412702IPR003527
DomainMAPK

MAPK8 MAPK10

8.92e-0412702PS01351
DomainUBIQUITIN_2

SACS SUMO3 SUMO2

1.09e-0354703PS50053
DomainRasGAP

IQGAP3 IQGAP1

1.22e-0314702SM00323
DomainRasGAP_CS

IQGAP3 IQGAP1

1.22e-0314702IPR023152
DomainUbiquitin_dom

SACS SUMO3 SUMO2

1.34e-0358703IPR000626
DomainCH

LMO7 IQGAP3 IQGAP1

1.86e-0365703SM00033
DomainCH

LMO7 IQGAP3 IQGAP1

2.31e-0370703PF00307
DomainIQ

PPEF1 IQGAP3 IQGAP1

2.40e-0371703PF00612
Domain-

LMO7 IQGAP3 IQGAP1

2.40e-03717031.10.418.10
DomainCH

LMO7 IQGAP3 IQGAP1

2.60e-0373703PS50021
DomainCH-domain

LMO7 IQGAP3 IQGAP1

2.81e-0375703IPR001715
DomainIQ

PPEF1 IQGAP3 IQGAP1

3.49e-0381703SM00015
DomainIQ_motif_EF-hand-BS

PPEF1 IQGAP3 IQGAP1

4.69e-0390703IPR000048
DomainIQ

PPEF1 IQGAP3 IQGAP1

5.14e-0393703PS50096
DomainZF_PHD_1

PHF20L1 ATRX PHF3

5.62e-0396703PS01359
DomainProt_kinase_dom

ERN1 TBCK PKDCC RET MAPK8 MAPK10

9.97e-03489706IPR000719
DomainPROTEIN_KINASE_DOM

ERN1 TBCK PKDCC RET MAPK8 MAPK10

1.04e-02493706PS50011
PathwayKEGG_MEDICUS_REFERENCE_IRE1A_JNK_SIGNALING_PATHWAY

ERN1 MAPK8 MAPK10

1.45e-067503M47697
PathwayREACTOME_VITAMIN_D_CALCIFEROL_METABOLISM

LGMN CYP2R1 SUMO2

9.03e-0612503M27088
PathwayKEGG_MEDICUS_PATHOGEN_HIV_VPR_TAT_TO_TNF_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

1.22e-045502M47570
PathwayKEGG_MEDICUS_ENV_FACTOR_PARAQUAT_TO_FAS_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

1.22e-045502M49021
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_TNF_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

1.22e-045502M49005
PathwayREACTOME_SUMO_IS_CONJUGATED_TO_E1_UBA2_SAE1

SUMO3 SUMO2

1.22e-045502M27223
PathwayBIOCARTA_SUMO_PATHWAY

SUMO3 SUMO2

1.83e-046502M22055
PathwayREACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED

SUMO3 SUMO2

1.83e-046502M27225
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TNF_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

1.83e-046502M47680
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_IRE1A_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

1.83e-046502M47698
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_DJ1_TO_FAS_JNK_SIGNALING_PATWHAY

MAPK8 MAPK10

1.83e-046502M47712
PathwayBIOCARTA_SUMO_PATHWAY

SUMO3 SUMO2

2.56e-047502MM1570
PathwayREACTOME_SUMO_IS_PROTEOLYTICALLY_PROCESSED

SUMO3 SUMO2

2.56e-047502MM14928
PathwayREACTOME_SUMO_IS_TRANSFERRED_FROM_E1_TO_E2_UBE2I_UBC9

SUMO3 SUMO2

2.56e-047502M27224
PathwayKEGG_MEDICUS_REFERENCE_FAS_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

2.56e-047502M47711
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

3.41e-048502M47814
PathwayWP_NONCLASSICAL_ROLE_OF_VITAMIN_D

CYP2R1 AGTR1

3.41e-048502M42566
PathwayREACTOME_VITAMIN_D_CALCIFEROL_METABOLISM

CYP2R1 SUMO2

3.41e-048502MM14766
PathwayREACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER

CUL4A SUMO3 SUMO2

4.69e-0443503M1005
PathwayREACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER

CUL4A SUMO3 SUMO2

5.36e-0445503MM15302
PathwayREACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS

MAPK8 MAPK10

5.45e-0410502MM15135
PathwayREACTOME_PROCESSING_AND_ACTIVATION_OF_SUMO

SUMO3 SUMO2

5.45e-0410502M27235
PathwayREACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS

MAPK8 MAPK10

5.45e-0410502M13962
PathwayWP_EXERCISEINDUCED_CIRCADIAN_REGULATION

KLF9 BTG1 SUMO3

6.49e-0448503M39444
PathwayREACTOME_PROCESSING_AND_ACTIVATION_OF_SUMO

SUMO3 SUMO2

6.64e-0411502MM14937
PathwayWP_EXERCISEINDUCED_CIRCADIAN_REGULATION

KLF9 BTG1 SUMO3

6.90e-0449503MM15870
PathwayKEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

7.95e-0412502M47929
PathwayPID_RAC1_PATHWAY

MAPK8 IQGAP3 IQGAP1

9.17e-0454503M278
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

9.38e-0413502M47594
PathwayREACTOME_RHOQ_GTPASE_CYCLE

DEPDC1B IQGAP3 IQGAP1

1.13e-0358503MM15602
PathwayREACTOME_RHOQ_GTPASE_CYCLE

DEPDC1B IQGAP3 IQGAP1

1.19e-0359503M41812
PathwayKEGG_MEDICUS_REFERENCE_TNF_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

1.43e-0316502M47569
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS

SUMO3 SUMO2

1.43e-0316502MM14938
PathwayREACTOME_RHOA_GTPASE_CYCLE

ARHGAP42 DEPDC1B IQGAP3 IQGAP1

1.59e-03142504MM15576
PathwayREACTOME_RHOA_GTPASE_CYCLE

ARHGAP42 DEPDC1B IQGAP3 IQGAP1

1.89e-03149504M41805
PathwayPID_CDC42_PATHWAY

MAPK8 IQGAP3 IQGAP1

1.94e-0370503M81
PathwayREACTOME_RHOC_GTPASE_CYCLE

DEPDC1B IQGAP3 IQGAP1

1.94e-0370503MM15597
PathwayKEGG_MEDICUS_REFERENCE_IL1_IL1R_JNK_SIGNALING_PATHWAY

MAPK8 MAPK10

2.03e-0319502M47471
PathwayREACTOME_CDC42_GTPASE_CYCLE

ARHGAP42 DEPDC1B IQGAP3 IQGAP1

2.19e-03155504M41808
PathwayWP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER

NTN1 MAPK8 MAPK10

2.19e-0373503M39758
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS

SUMO3 SUMO2

2.25e-0320502M27237
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PTP

MAPK8 MAPK10

2.25e-0320502M47928
PathwayREACTOME_RHOC_GTPASE_CYCLE

DEPDC1B IQGAP3 IQGAP1

2.28e-0374503M41807
PathwayWP_PEPTIDE_GPCRS

AGTR1 NTSR1 HCRTR2

2.37e-0375503M39696
PathwayWP_REGULATORY_CIRCUITS_OF_STAT3_SIGNALING

AGTR1 MAPK8 MAPK10

2.65e-0378503M39824
PathwayREACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1

MAPK8 MAPK10

2.72e-0322502M859
PathwayREACTOME_NPAS4_REGULATES_EXPRESSION_OF_TARGET_GENES

RET SYT10

2.72e-0322502M46437
PathwayREACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1

MAPK8 MAPK10

2.97e-0323502MM15134
PathwayWP_ROLES_OF_CERAMIDES_IN_DEVELOPMENT_OF_INSULIN_RESISTANCE

ERN1 MAPK8

2.97e-0323502M45533
PathwayPID_REG_GR_PATHWAY

SUMO2 MAPK8 MAPK10

3.05e-0382503M115
PathwayREACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER

CUL4A SUMO3 SUMO2

3.16e-0383503MM15305
PathwayREACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER

CUL4A SUMO3 SUMO2

3.27e-0384503M27594
PathwayREACTOME_RAC1_GTPASE_CYCLE

ARHGAP42 DEPDC1B IQGAP3 IQGAP1

3.39e-03175504MM15599
Pubmed

Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity.

SENP3 SUMO3 SUMO2

8.51e-09372328747609
Pubmed

SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress.

SENP3 SUMO3 SUMO2

3.40e-08472320181954
Pubmed

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3.

SENP3 SUMO3 SUMO2

1.69e-07672318948745
Pubmed

Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.

SENP3 SUMO3 SUMO2

4.73e-07872316608850
Pubmed

RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.

SENP3 SUMO3 SUMO2

1.01e-061072318946085
Pubmed

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.

ERN1 MAPK8 MAPK10

3.05e-061472319805353
Pubmed

Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.

ERN1 NTN1

4.23e-06272223473031
Pubmed

Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b.

CORO1A CORO1B

4.23e-06272221844203
Pubmed

Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy.

NTSR1 DBH

4.23e-06272215353215
Pubmed

Neuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms.

MAPK8 MAPK10

4.23e-06272228664455
Pubmed

SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner.

SUMO3 SUMO2

4.23e-06272221291420
Pubmed

c-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice.

MAPK8 MAPK10

4.23e-06272221824499
Pubmed

A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase.

SENP3 SUMO2

4.23e-06272211029585
Pubmed

Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.

SUMO3 SUMO2

4.23e-06272210692421
Pubmed

SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response.

SUMO3 SUMO2

4.23e-06272229891701
Pubmed

The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle.

SUMO3 SUMO2

4.23e-06272218565875
Pubmed

Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.

SUMO3 SUMO2

4.23e-06272225047847
Pubmed

SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis.

SUMO3 SUMO2

4.23e-06272222306003
Pubmed

SUMOylation of nuclear actin.

SUMO3 SUMO2

4.23e-06272219635839
Pubmed

SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development.

SENP3 SUMO3 SUMO2

4.67e-061672338925188
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

GAPVD1 ATRX LMO7 PHF3 SUMO2 NIBAN2 IQGAP1

5.87e-0633272732786267
Pubmed

JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy.

MAPK8 MAPK10

1.27e-05372230685843
Pubmed

JNK1 is required to preserve cardiac function in the early response to pressure overload.

MAPK8 MAPK10

1.27e-05372216579967
Pubmed

Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells.

ERN1 MAPK8

1.27e-05372227044747
Pubmed

Specific pathophysiological functions of JNK isoforms in the brain.

MAPK8 MAPK10

1.27e-05372215673436
Pubmed

Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men.

SUMO3 SUMO2

1.27e-05372218694876
Pubmed

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.

ERN1 MAPK8

1.27e-05372222128176
Pubmed

Small Ubiquitin-like Modifier Alters IFN Response.

SUMO3 SUMO2

1.27e-05372226223657
Pubmed

Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins.

SUMO3 SUMO2

1.27e-05372217077080
Pubmed

Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains.

SUMO3 SUMO2

1.27e-05372226223632
Pubmed

Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3.

SUMO3 SUMO2

1.27e-05372230761470
Pubmed

Retinoic acid modulates the subcellular localization of small ubiquitin-related modifier-2/3 (SUMO-2/3) in the testis.

SUMO3 SUMO2

1.27e-05372220075418
Pubmed

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin.

CORO1A CORO1B

1.27e-05372222364218
Pubmed

Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway.

ERN1 MAPK8

1.27e-05372228349059
Pubmed

Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.

SUMO3 SUMO2

1.27e-05372230926672
Pubmed

Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity.

MAPK8 MAPK10

1.27e-05372215246824
Pubmed

Human c-Jun N-terminal kinase expression and activation in the nervous system.

MAPK8 MAPK10

1.27e-05372210101227
Pubmed

Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells.

MAPK8 MAPK10

1.27e-05372223485395
Pubmed

SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.

SUMO3 SUMO2

1.27e-05372218374647
Pubmed

The biology of IQGAP proteins: beyond the cytoskeleton.

IQGAP3 IQGAP1

1.27e-05372225722290
Pubmed

SUMOylation of HSP27 by small ubiquitin-like modifier 2/3 promotes proliferation and invasion of hepatocellular carcinoma cells.

SUMO3 SUMO2

1.27e-05372228665748
Pubmed

A critical role of neural-specific JNK3 for ischemic apoptosis.

MAPK8 MAPK10

1.27e-05372214657393
Pubmed

SAPKgamma/JNK1 and SAPKalpha/JNK2 mRNA transcripts are expressed in early gestation human placenta and mouse eggs, preimplantation embryos, and trophoblast stem cells.

MAPK8 MAPK10

1.27e-05372215474087
Pubmed

Sumoylation dynamics during keratinocyte differentiation.

SUMO3 SUMO2

1.27e-05372217164289
Pubmed

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model.

MAPK8 MAPK10

1.27e-05372217056565
Pubmed

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.

IQGAP3 IQGAP1

1.27e-05372222493426
Pubmed

Opposing biological functions of the cytoplasm and nucleus DAXX modified by SUMO-2/3 in gastric cancer.

SUMO3 SUMO2

1.27e-05372232641734
Pubmed

SUMO paralogue-specific functions revealed through systematic analysis of human knockout cell lines and gene expression data.

SUMO3 SUMO2

1.27e-05372234232706
Pubmed

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases.

MAPK8 MAPK10

1.27e-05372234502556
Pubmed

Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules.

CORO1A CORO1B

1.27e-05372215800061
Pubmed

Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.

IQGAP3 IQGAP1

1.27e-05372225229330
Pubmed

Different SUMO paralogues determine the fate of wild-type and mutant CFTRs: biogenesis versus degradation.

SUMO3 SUMO2

1.27e-05372230403549
Pubmed

Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons.

SUMO3 SUMO2

1.27e-05372222945749
Pubmed

The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation.

SUMO3 SUMO2

1.27e-05372224267727
Pubmed

SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.

SUMO3 SUMO2

1.27e-0537229119407
Pubmed

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.

MAPK8 MAPK10

1.27e-05372214517246
Pubmed

Knockout of c-Jun N-terminal kinases 1, 2 or 3 isoforms induces behavioural changes.

MAPK8 MAPK10

1.27e-05372223428746
Pubmed

Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.

SUMO3 SUMO2

1.27e-05372223078246
Pubmed

Gene expression profile in JNK3 null mice: a novel specific activation of the PI3K/AKT pathway.

MAPK8 MAPK10

1.27e-05372221255018
Pubmed

SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80-K307.

SUMO3 SUMO2

1.27e-05372237338025
Pubmed

Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning.

MAPK8 MAPK10

1.27e-05372220926661
Pubmed

Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa.

SUMO3 SUMO2

1.27e-05372223077236
Pubmed

SUMO2/3 modification of activating transcription factor 5 (ATF5) controls its dynamic translocation at the centrosome.

SUMO3 SUMO2

1.27e-05372229326161
Pubmed

NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.

SUMO3 SUMO2

1.27e-05372234504059
Pubmed

SUMO2/3 conjugation is an endogenous neuroprotective mechanism.

SUMO3 SUMO2

1.27e-05372221863037
Pubmed

Distinct in vivo dynamics of vertebrate SUMO paralogues.

SUMO3 SUMO2

1.27e-05372215456902
Pubmed

JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis.

MAPK8 MAPK10

1.27e-05372219609503
Pubmed

A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.

ERN1 MAPK8

1.27e-05372224936061
Pubmed

Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma.

SUMO3 SUMO2

1.27e-05372226458400
Pubmed

The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.

NTN1 RET MEIS1

1.27e-052272322748019
Pubmed

Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.

SENP3 SUMO3 SUMO2

1.46e-052372330992372
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CUL4A CORO1A GAPVD1 ATRX LMO7 EXOC6B PYGL CORO1B NDUFA9 DEPDC1B IQGAP3 IQGAP1

1.60e-051321721227173435
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

GAPVD1 SACS LMO7 SENP3 SUMO2 CORO1B IQGAP3

1.96e-0540072735013556
Pubmed

Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death.

DBH RET MEIS1

2.14e-052672326857994
Pubmed

Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.

AGTR1 NTSR1

2.53e-05472211279203
Pubmed

Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.

SUMO3 SUMO2

2.53e-05472225406032
Pubmed

Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.

SUMO3 SUMO2

2.53e-05472218708356
Pubmed

Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.

SUMO3 SUMO2

2.53e-05472215487983
Pubmed

Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth.

SUMO3 SUMO2

2.53e-05472217428805
Pubmed

Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.

LGMN DBH

2.53e-05472231793911
Pubmed

MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity.

SUMO3 SUMO2

2.53e-05472221900752
Pubmed

Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3.

SUMO3 SUMO2

2.53e-05472212810706
Pubmed

A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.

SUMO3 SUMO2

2.53e-05472215296745
Pubmed

Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).

MAPK8 MAPK10

2.53e-05472215228592
Pubmed

Crystal structure of SUMO-3-modified thymine-DNA glycosylase.

SUMO3 SUMO2

2.53e-05472216626738
Pubmed

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis.

MAPK8 MAPK10

2.53e-05472212818176
Pubmed

JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.

MAPK8 MAPK10

2.53e-05472220525557
Pubmed

c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis.

MAPK8 MAPK10

2.53e-05472216824735
Pubmed

Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate.

MAPK8 MAPK10

2.53e-05472222372722
Pubmed

Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover.

SUMO3 SUMO2

2.53e-05472211889051
Pubmed

JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases.

MAPK8 MAPK10

2.53e-0547229393873
Pubmed

Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.

SUMO3 SUMO2

2.53e-05472224690371
Pubmed

The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers.

SUMO3 SUMO2

2.53e-05472226867680
Pubmed

Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein.

MAPK8 MAPK10

2.53e-05472215693750
Pubmed

A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1.

MAPK8 MAPK10

2.53e-05472210471813
Pubmed

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.

MAPK8 MAPK10

2.53e-05472217724133
Pubmed

c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.

MAPK8 MAPK10

2.53e-05472215528206
Pubmed

Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.

IQGAP3 IQGAP1

2.53e-05472228970065
Pubmed

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia.

SENP3 SUMO2

2.53e-05472223524851
Pubmed

Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model.

SUMO3 SUMO2

2.53e-05472221843595
GeneFamilyWD repeat domain containing|Coronins

CORO1A CORO6 CORO1B

6.10e-077483495
GeneFamilyMitogen-activated protein kinases

MAPK8 MAPK10

5.28e-0413482651
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP42 LMO7 AGTR1 RET MEIS1

1.12e-05181725a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP42 LMO7 AGTR1 RET MEIS1

1.12e-05181725526e858a848470b6d2d5248788004d9735ed3add
ToppCellE12.5-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SCRG1 DBH RET MAPK10 SVOP

1.38e-05189725620d30bb6211fff6adab0638d0d994f547167a29
ToppCell(1)_T_cells-(1)_T_CD4_naive|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

TRABD2A TUT4 ATRX LMO7 PHF3

1.61e-05195725d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CORO1A TUT4 ATRX PHF3 SUMO2

1.73e-051987254c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

ATRX LMO7 PHF3 KLF9 IQGAP1

1.77e-05199725fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

CORO6 NTN1 RET HCRTR2

9.98e-051497246e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SIDT2 PKDCC PYGL CORO1B

1.22e-041577244766f7d545bf2d775390589460677519cb92f4d5
ToppCellfacs-Lung-Endomucin-24m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A SIDT2 BTG1 PYGL

1.25e-041587240ed844ab625351a46b74edddf082279ed1bae5c6
ToppCellfacs-Lung-Endomucin-24m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A SIDT2 BTG1 PYGL

1.25e-04158724b3a810314e253b4fd0f578e759c36fdd21722934
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LGMN CYP2R1 DEPDC1B PDLIM4

1.38e-04162724ec29c6f1c31e41ddcb041a49c593910edaf0532c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO7 AGTR1 PYGL MEIS1

1.44e-04164724b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CORO1A SVOP DEPDC1B IQGAP3

1.44e-041647241642a67c66eeb77a218e7814e3cfe517d9822955
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CORO1A SVOP DEPDC1B IQGAP3

1.44e-0416472425758fb8112baf296264122d5d4121f1ebb3d0fa
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANO5 DBH RET SVOP

1.44e-04164724be49af6335f2505065cde2cb9800e4a5516811b1
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN CMIP SNX32 NTN1

1.55e-04167724a4a795751644b22af616335379e64ae95175180c
ToppCelldroplet-Marrow-BM-30m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A BTG1 PYGL SCRG1

1.55e-04167724f90cf0f29c14df4f211193326699e599ef955fa4
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP42 PRDM10 AGTR1 FOXF2

1.58e-041687241bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP42 PRDM10 AGTR1 FOXF2

1.58e-0416872469f534de0f9a293047bea03cb1b78551087a8df5
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 LMO7 TANC1 NIBAN2

1.66e-04170724a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC1 RET DEPDC1B IQGAP3

1.69e-04171724913bae728b5e653771a27c79a309eb023699f1d0
ToppCelldroplet-Marrow-nan-21m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A BTG1 PYGL SCRG1

1.69e-04171724d6ae456e88ec49a8609a5e5e3af9f51921e66744
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC1 RET DEPDC1B IQGAP3

1.69e-04171724f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP42 AGTR1 PYGL MEIS1

1.73e-0417272408a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP42 AGTR1 PYGL MEIS1

1.73e-04172724553701349444eb366df3c11f54bb093434f153c6
ToppCellAdult-Mesenchymal-pericyte_cell-D175|Adult / Lineage, Cell type, age group and donor

ARHGAP42 AGTR1 DEPDC1B FOXF2

1.77e-04173724fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCellCOVID-19-kidney-REN+Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGAP42 AGTR1 RET MEIS1

1.81e-041747248393f0b43c767839c1630bcb952d62b42efc788d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO7 AGTR1 RET MEIS1

1.85e-041757241b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NTSR1 DBH MAPK10 PPEF1

1.85e-041757242ce8bcf9926862e723219b4246388428d0c3fdee
ToppCelldroplet-Marrow-nan-21m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A BTG1 PYGL MEIS1

1.89e-04176724a5ec032fe39172be11ffdda5af515c8d38731d9a
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SACS PKDCC MAPK10 PDLIM4

1.89e-041767244ed73c73972334f6dc4229920205547823252fa0
ToppCelldroplet-Marrow-nan-21m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A BTG1 PYGL MEIS1

1.89e-04176724b1b921f96b6a3cbfbd156d7b74f06c82c4e199d0
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARHGAP42 AGTR1 DBH FOXF2

1.93e-04177724452ec2df36c6d656a7cdadc55be545ccdb146a29
ToppCellMild-Lymphoid-T-innate_T|Mild / Condition, Lineage, Cell class and cell subclass

OR2B11 CORO1A ERN1 BTG1

2.02e-04179724abc0fbe101a464a2c85755a974a3d5c2b968fe46
ToppCellfacs-Kidney-nan-18m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAPPC11 CORO1A CACNA1I MAPK8

2.02e-04179724f4fd214a9865c635d8a744ce5e0eff45174d3de4
ToppCellfacs-Kidney-nan-18m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAPPC11 CORO1A CACNA1I MAPK8

2.02e-0417972457d8d44a793314eec8f77030f4177bfe21d41652
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARHGAP42 AGTR1 CORO6 FOXF2

2.02e-04179724dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 NTN1 MEIS1 FOXF2

2.02e-0417972402c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellwk_15-18-Epithelial-PNS-KCNIP4+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DBH RET PPEF1 SVOP

2.02e-04179724e20bfdfb6d5af8556eb66b81a19fbe4e3e28334a
ToppCell(3)_Chondrocytes-(32)_Chondro-prehyper-2|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis

LGMN LMO7 BTG1 SCRG1

2.06e-04180724708a5c89b9337e281fce4f482892a1c1766c7812
ToppCellfacs-MAT-Fat-24m-Lymphocytic-B_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A BTG1 CACNA1I HCRTR2

2.06e-04180724711719219bcbafdd505790eda895e7a33f21bed2
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 NTN1 MEIS1 FOXF2

2.06e-0418072401f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCRG1 PPEF1 SYT10 PDLIM4

2.11e-04181724098dbb3e0ff531c9720a233123250c1e39a97d4c
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

TRABD2A CORO1A BTG1 CACNA1I

2.11e-041817249b155a74e68e485039a5195144a12833f2f75058
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

ARHGAP42 LMO7 NIBAN2 MAPK10

2.11e-04181724c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NTSR1 PYGL NIBAN2 PDLIM4

2.20e-041837244763df29c888d47c22076803b054f06b4cc29368
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NTSR1 PYGL NIBAN2 PDLIM4

2.20e-04183724fcb0f755382d88fb207fc2322cd224c09c6e2ea6
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CMIP MAPK10 SYT10 FOXF2

2.20e-04183724af8d86f15a549064530d94bd47081daf59d58ecd
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 TRABD2A AGTR1 FOXF2

2.24e-04184724689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCellCOPD-Stromal-Pericyte|COPD / Disease state, Lineage and Cell class

ARHGAP42 AGTR1 TANC1 FOXF2

2.24e-04184724a56264a22dfc2d3672b20134ab7c3c7c23da5ae1
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUT4 ATRX PHF3 IQGAP1

2.24e-041847241154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 LMO7 NIBAN2 MAPK10

2.24e-04184724102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 NTN1 SYT10 MEIS1

2.29e-04185724e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP42 NTN1 MEIS1 PDLIM4

2.29e-04185724e58a009aaf342be019a909747b1895d5987d4daf
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 NTN1 SYT10 MEIS1

2.34e-041867246add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCellwk_15-18-Epithelial-PNS-MFNG+_DBH+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DBH RET PPEF1 SVOP

2.34e-0418672472f7427d62d65e37bb0bf99229a1b75df081a128
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2A ERN1 BTG1 CACNA1I

2.34e-04186724bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A BTG1 CACNA1I IQGAP1

2.34e-04186724a8fcb440d88770f95678c5d28413fc4d847f42a8
ToppCelldroplet-Spleen-nan-3m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A TUT4 ATRX BTG1

2.34e-0418672426f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX SACS LMO7 TANC1

2.34e-041867240ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORO1A BTG1 CACNA1I IQGAP1

2.34e-041867246b2d15e2756d4d4d68ad600e4a6c074edc3488f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2A ERN1 BTG1 CACNA1I

2.34e-04186724924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO7 AGTR1 RET MEIS1

2.38e-04187724d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Activated_CD4_T|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERN1 BTG1 CACNA1I DBH

2.38e-041877246bdc55213e41346c5914a290b16172cd412ac71d
ToppCellPCW_05-06-Neuronal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SCRG1 NTN1 DBH RET

2.38e-0418772403a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCellPND03|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LMO7 BTG1 PYGL IQGAP1

2.38e-04187724b3fcb36d853adfdea7172c5591de06f027e50af3
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 AGTR1 MEIS1 FOXF2

2.38e-0418772486250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO7 AGTR1 RET MEIS1

2.38e-04187724d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO7 AGTR1 RET MEIS1

2.38e-04187724ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP42 NTN1 MEIS1 FOXF2

2.38e-04187724c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 NTN1 SYT10 MEIS1

2.43e-041887243177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DBH RET PPEF1 PDLIM4

2.43e-041887249fd262bbf6cdebfd945e39428a6059726fb55b3a
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 NTN1 SYT10 MEIS1

2.43e-04188724293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCelldroplet-Spleen-nan-3m-Lymphocytic-B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN CORO1A TUT4 BTG1

2.43e-041887248b1485e63cd4020ba5334a8d4b84725b164549bf
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DBH RET PPEF1 PDLIM4

2.43e-04188724459e3fd4335a6f25f982d011b38702f4fcfed1cd
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

TANC1 DEPDC1B MEIS1 IQGAP1

2.43e-04188724b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

ARHGAP42 NTN1 MEIS1 FOXF2

2.48e-0418972444e37f88137bb249933eb615235b2cf2ae7f3925
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DBH RET PPEF1 SVOP

2.48e-04189724de06ef69f3f97b3f21dc269eb6965da9b2f6e3f8
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP42 NTN1 SYT10 MEIS1

2.48e-041897247ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellIPF-Epithelial-Club|IPF / Disease state, Lineage and Cell class

ARHGAP42 LMO7 NTN1 TANC1

2.48e-04189724f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_Tregs|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

LGMN CORO1A SUMO2 CORO1B

2.53e-04190724f69a4733b5d1542ab4d0eb44856f2c5c34c18b9e
ToppCellMesenchymal-airway_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

ARHGAP42 NTN1 MEIS1 FOXF2

2.53e-04190724645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCellT_cells-Effector_memory_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

TRABD2A ERN1 BTG1 CACNA1I

2.53e-0419072413dc3a0aaa554f63eabac37726bd1f11b66fb3dd
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN TUT4 BTG1 IQGAP1

2.53e-04190724ee7b60cdf93c695ea2d59a170ca8cf4dc93e7eb2
ToppCellT_cells-Effector_memory_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

ERN1 KLF9 BTG1 CACNA1I

2.53e-041907241af91fe0ee2c924e12f4db93c793e7af475d8f80
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CMIP ATRX PHF3 IQGAP1

2.58e-0419172460c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

LMO7 EXOC6B NTN1 TANC1

2.58e-041917245d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ARHGAP42 LMO7 NTN1 MAPK10

2.58e-0419172423776c7302cead3881b39127398f3b3e0d27885e
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

GAPVD1 GLG1 TBCK IQGAP1

2.58e-041917249454f642c3621370fa23640b631301346b300950
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2A CORO1A ERN1 BTG1

2.58e-041917241a2d5fec2bea96da2154b0aed252f1bb35102f6e
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

ARHGAP42 LMO7 NTN1 TANC1

2.58e-041917243c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellsevere_COVID-19-CD4+_T_naive|World / disease group, cell group and cell class (v2)

TRABD2A LMO7 CACNA1I DBH

2.58e-0419172455a282478488efd1561ea57a6f0218f55f711bb0
ToppCellILEUM-non-inflamed-(1)_Tregs|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CORO1A BTG1 SUMO2 CORO1B

2.58e-04191724e065d16a1f88c91dec576d248a318534ceab1cb2
ToppCell(1)_Control_(PBS)|World / Stress and Cell class

LGMN LMO7 KLF9 BTG1

2.58e-04191724b346e13259cb2d506b923ad44b894c21a3eee4c3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2A CORO1A ERN1 BTG1

2.58e-04191724326b4541069efedc8ab409f85bb11f77346dda90
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CMIP ATRX PHF3 IQGAP1

2.58e-0419172409db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CMIP ATRX PHF3 IQGAP1

2.58e-04191724973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellCOPD-Epithelial|COPD / Disease state, Lineage and Cell class

ARHGAP42 LMO7 TANC1 MAPK10

2.64e-041927240644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CORO1A ERN1 BTG1 CORO1B

2.64e-041927241b0138fd0bfdee266325751f8b2d163d91a71bf5
ToppCellILEUM-inflamed-(1)_Tregs|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CORO1A BTG1 SUMO2 CORO1B

2.64e-041927241fe3417dfd1cf1758fd82c9ac13dbd88bdf0b548
Diseasesleep duration, circadian rhythm, excessive daytime sleepiness measurement, insomnia measurement

MEIS1 HCRTR2

1.58e-048712EFO_0004354, EFO_0005271, EFO_0007875, EFO_0007876
DiseaseAutosomal recessive limb-girdle muscular dystrophy

TRAPPC11 ANO5

5.10e-0414712cv:C2931907
DiseaseParkinson's disease (is_marker_for)

AGTR1 NTSR1 DBH

5.73e-0467713DOID:14330 (is_marker_for)
Diseaseunipolar depression, response to escitalopram, response to citalopram, mood disorder

CORO1B FOXF2

5.87e-0415712EFO_0003761, EFO_0004247, EFO_0006329, EFO_0007871
DiseasePheochromocytoma, Extra-Adrenal

DBH RET

6.70e-0416712C1257877
DiseaseTourette syndrome, schizophrenia

PHF3 CACNA1I

8.52e-0418712EFO_0004895, MONDO_0005090
DiseasePheochromocytoma

DBH RET

9.51e-0419712C0031511
Diseaseserum alanine aminotransferase measurement

OR2B11 ANO5 TOR1B SUMO3 SUMO2 KLHL8 RMC1 MAPK10

1.13e-03869718EFO_0004735
DiseaseLimb-girdle muscular dystrophy

TRAPPC11 ANO5

1.79e-0326712cv:C0686353
Diseaseanti-basement membrane glomerulonephritis (biomarker_via_orthology)

AGTR1 MAPK8

2.38e-0330712DOID:4780 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KKHLCLYLALKPRMD

CEP295NL

356

Q96MC4
KCKPHMNYDKLSRAL

ERFL

86

A0A1W2PQ73
LRPEFEAMCKHRKLN

ANO5

426

Q75V66
CLSIDRYLAIVHPMK

AGTR1

121

P30556
AEKHCPMARYVLKTD

B3GALT4

161

O96024
LKHNMDFGKCPRLRL

CMIP

271

Q8IY22
RFYKLHERKCEPIVM

CORO1B

336

Q9BR76
VELFRAKMPLRKHRC

DEPDC1B

21

Q8WUY9
AKMPLRKHRCRFKSY

DEPDC1B

26

Q8WUY9
RFYKLHERRCEPIAM

CORO1A

336

P31146
DRKNMPRCIYCIHAL

IQGAP1

141

P46940
CRKMYNRPHRAPITK

NTN1

181

O95631
KLSRLAYHPLKMQSC

NIBAN2

391

Q96TA1
PLCEKRFMRSDHLTK

KLF9

206

Q13886
HRYISCLKGKMPIDL

MEIS1

171

O00470
KAAYRRLCMLYHPDK

DNAJC11

31

Q9NVH1
KRAYRELVLMKCVNH

MAPK10

106

P53779
RYLAICHPFKAKTLM

NTSR1

166

P30989
AYKTPRDKVQCILRM

GAPVD1

1386

Q14C86
HKLVLACVIPYFRAM

KLHL8

81

Q9P2G9
HAKRAYRELVLMKCV

MAPK8

66

P45983
CRILVPSYRQKKDDM

LMO7

626

Q8WWI1
HYRFCKVMVDNIPKL

EXOC6B

176

Q9Y2D4
KAFCRPDKLRLHMLR

PRDM10

651

Q9NQV6
IIPYRCDKYDIMHLR

NDUFA9

81

Q16795
DKKNMPRVVYCIHAL

IQGAP3

131

Q86VI3
ICHPLRYAVLMNKKV

OR2AE1

126

Q8NHA4
AMALDRYVAICKPLH

OR2B11

121

Q5JQS5
KAFPLQRMLTRHLKC

OVOL3

101

O00110
ICHPLMFKSTAKRAR

HCRTR2

156

O43614
DYRLNPMLRKACKAD

GLG1

931

Q92896
KKRAHILYEMLAGCV

ATRX

1801

P46100
LRAMRNKKHHYRELP

ERN1

901

O75460
CKMPYTEAVLHEVLR

CYP2R1

356

Q6VVX0
HKVSPMLYKQLRQAC

CUL4A

96

Q13619
LCFRVRKMIDVYKPD

CACNA1I

1126

Q9P0X4
KMKPDRLNYCRHVLA

DBH

286

P09172
LYLCKRAELIPSHRM

ANKMY1

841

Q9P2S6
FYKLHERKCEPIIMT

CORO6

336

Q6QEF8
LYNCIHEDMKRLLPV

SACS

2981

Q9NZJ4
LKMLIRSHECKPEGY

PPEF1

396

O14829
YDGVIRCLKRMHIKA

PHF20L1

121

A8MW92
FRRKCQALKPMYHRV

FOXF2

196

Q12947
VCSKMVPRYDLNRHL

FAN1

46

Q9Y2M0
LYAEFLPMKARAKCI

SVOP

196

Q8N4V2
IAGLCMLKLYQKRHP

SIDT2

586

Q8NBJ9
RGCYRLAAHKLLKEM

PKDCC

186

Q504Y2
RLKLRPLYQFMSCKE

TADA2B

256

Q86TJ2
LRCLAEPLMTYKLHK

ARHGAP42

461

A6NI28
IVKARDKLYHPECFM

PDLIM4

266

P50479
FLIKRRDKTRMFCHP

TANC1

801

Q9C0D5
ETKLVTCYLRMRKPD

SPATA16

231

Q9BXB7
TCYLRMRKPDLALNH

SPATA16

236

Q9BXB7
MPANRLSCYRKILKD

SCRG1

21

O75711
GYRCIRINHKMDPLI

BTG1

66

P62324
HTPLSKLMKAYCERQ

SUMO3

36

P55854
MPKLRRQIYKELCHC

SENP3

556

Q9H4L4
ISHKRIHMELRPYKC

ZNF727

356

A8MUV8
LHPGEQLEKMLYVRC

TRAPPC11

831

Q7Z392
VVLYHLPREGACKKM

RMC1

241

Q96DM3
VIHFRMYCPPRLKAK

nan

51

Q8N8P6
CFLRHERIHMREKPY

ZNF799

546

Q96GE5
CMSLKPEYHKENRRC

PHF3

186

Q92576
RHTPLSKLMKAYCER

SUMO2

36

P61956
CRLKRHLEYVKLMMP

TRABD2A

121

Q86V40
HLVKMKYPRICILDG

TBCK

861

Q8TEA7
PYVKVSLMCEGRRLK

SYT10

401

Q6XYQ8
KALRRPKCAELHYMV

RET

471

P07949
KRKHSREKPYMCRQC

ZNF133

541

P52736
TKYRKRLDAAPHMRI

ZBED5

656

Q49AG3
VMRAHKCLADDYIPI

SNX32

231

Q86XE0
IGHYMKDCPKRKSLL

TUT4

1301

Q5TAX3
CLHVITMYNRIKKDP

PYGL

581

P06737
FLPLEYRHVKMCVRA

TOR1B

276

O14657
LCEKPYPLHRIKLSM

LGMN

411

Q99538