Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	abnormal retina photoreceptor morphology	FMR1 LMO7 ATOH7 WDR81 SLC24A1 AGTPBP1	2.78e-05	206	41	6	MP:0001004
MousePheno	abnormal retina photoreceptor layer morphology	FMR1 LMO7 ATOH7 WDR81 SLC24A1 AGTPBP1	3.54e-05	215	41	6	MP:0003728
MousePheno	abnormal sensory neuron morphology	FMR1 LMO7 ATOH7 WDR81 SLC24A1 SLC4A3 HES5 AGTPBP1	5.78e-05	473	41	8	MP:0000965
MousePheno	abnormal retina rod cell morphology	FMR1 ATOH7 SLC24A1 AGTPBP1	7.77e-05	78	41	4	MP:0001005
MousePheno	abnormal retina layer morphology	FMR1 LMO7 ATOH7 SOX30 WDR81 PRPF8 SLC24A1 AGTPBP1	9.03e-05	504	41	8	MP:0003727
MousePheno	abnormal somatic nervous system morphology	FMR1 MEGF8 LMO7 ATOH7 WDR81 TRIOBP SLC24A1 SLC4A3 HES5 CHRNB1 AGTPBP1	1.27e-04	1025	41	11	MP:0002752
MousePheno	abnormal retina morphology	FAM120A FMR1 LMO7 ATOH7 SOX30 WDR81 PRPF8 SLC24A1 PRDM16 SLC4A3 HES5 AGTPBP1	1.41e-04	1227	41	12	MP:0001325
MousePheno	abnormal somatic sensory system morphology	FMR1 LMO7 ATOH7 WDR81 TRIOBP SLC24A1 SLC4A3 HES5 AGTPBP1	1.59e-04	702	41	9	MP:0000959
MousePheno	abnormal ocular fundus morphology	FAM120A FMR1 LMO7 ATOH7 SOX30 WDR81 PRPF8 SLC24A1 PRDM16 SLC4A3 HES5 AGTPBP1	1.85e-04	1262	41	12	MP:0002864
MousePheno	abnormal retina neuronal layer morphology	FMR1 LMO7 ATOH7 SOX30 WDR81 SLC24A1 AGTPBP1	2.63e-04	441	41	7	MP:0006069
MousePheno	abnormal cochlear VIII nucleus morphology	IL17RD AGTPBP1	3.72e-04	10	41	2	MP:0012490
MousePheno	abnormal rod electrophysiology	RANBP2 ATOH7 SLC24A1 AGTPBP1	3.96e-04	119	41	4	MP:0004021
Domain	-	SUSD1 SVEP1	4.27e-04	11	53	2	2.40.155.10
Domain	GFP-like	SUSD1 SVEP1	4.27e-04	11	53	2	IPR023413
Domain	Sushi	SUSD1 SUSD2 SVEP1	4.32e-04	52	53	3	PF00084
Domain	CCP	SUSD1 SUSD2 SVEP1	4.83e-04	54	53	3	SM00032
Domain	SUSHI	SUSD1 SUSD2 SVEP1	5.38e-04	56	53	3	PS50923
Domain	Sushi_SCR_CCP_dom	SUSD1 SUSD2 SVEP1	5.67e-04	57	53	3	IPR000436
Domain	-	PIAS3 HNRNPUL2	1.60e-03	21	53	2	1.10.720.30
Domain	SAP	PIAS3 HNRNPUL2	1.76e-03	22	53	2	PF02037
Domain	EGF_CA	MEGF8 SUSD1 SVEP1	1.87e-03	86	53	3	PF07645
Domain	SAP	PIAS3 HNRNPUL2	1.92e-03	23	53	2	SM00513
Domain	SAP	PIAS3 HNRNPUL2	2.27e-03	25	53	2	PS50800
Domain	SAP_dom	PIAS3 HNRNPUL2	2.27e-03	25	53	2	IPR003034
Domain	EGF_Ca-bd_CS	MEGF8 SUSD1 SVEP1	2.64e-03	97	53	3	IPR018097
Domain	EGF_CA	MEGF8 SUSD1 SVEP1	2.79e-03	99	53	3	PS01187
Domain	ASX_HYDROXYL	MEGF8 SUSD1 SVEP1	2.87e-03	100	53	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	MEGF8 SUSD1 SVEP1	3.39e-03	106	53	3	IPR000152
Domain	EGF_CA	MEGF8 SUSD1 SVEP1	5.02e-03	122	53	3	SM00179
Domain	EGF-like_Ca-bd_dom	MEGF8 SUSD1 SVEP1	5.25e-03	124	53	3	IPR001881
Domain	SET	PRDM16 SMYD3	7.55e-03	46	53	2	SM00317
Pubmed	Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation.	ADCY10 ATOH7	2.46e-06	2	55	2	27679853
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	FAM120A FMR1 HNRNPUL2 LMO7 TRIOBP	3.70e-06	147	55	5	28977470
Pubmed	Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye.	ATOH7 HES5	7.36e-06	3	55	2	28675662
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	RANBP2 FAM120A FMR1 LMO7 ACLY TRIOBP PRPF8 AGTPBP1	1.74e-05	724	55	8	36232890
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	VPS18 FMR1 PIAS3 MEGF8 ACLY RALYL TRIOBP	2.81e-05	560	55	7	21653829
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF133 FAM120A PIAS3 LMO7 TRIOBP RNF216 PRPF8 SLC4A3 SMYD3 AGTPBP1	2.94e-05	1285	55	10	35914814
Pubmed	The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.	RANBP2 RAPGEF3	5.13e-05	7	55	2	20547757
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RANBP2 RAPGEF3	6.83e-05	8	55	2	21670213
Pubmed	LMO7 deficiency reveals the significance of the cuticular plate for hearing function.	LMO7 TRIOBP	6.83e-05	8	55	2	30850599
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RANBP2 FAM120A FMR1 HNRNPUL2 PTPRS WDR81 TRIOBP CNTN1	1.29e-04	963	55	8	28671696
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	MRPL4 RANBP2 VPS18 FAM120A FMR1 LMO7 ACLY PRPF8 NFU1	1.37e-04	1247	55	9	27684187
Pubmed	Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina.	ATOH7 HES5	2.21e-04	14	55	2	25100656
Pubmed	GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.	FAM120A ACLY	2.54e-04	15	55	2	31417184
Pubmed	Integral bHLH factor regulation of cell cycle exit and RGC differentiation.	ATOH7 HES5	2.54e-04	15	55	2	29770538
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	VPS18 FAM120A FMR1 HNRNPUL2 LMO7 PTPRS ACLY AGTPBP1 CNTN1	3.80e-04	1431	55	9	37142655
Pubmed	SOX2 is a dose-dependent regulator of retinal neural progenitor competence.	ATOH7 HES5	4.13e-04	19	55	2	16651659
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PRUNE2 LMO7 TRIOBP PRDM16	4.49e-04	225	55	4	12168954
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	MRPL4 FAM120A HNRNPUL2 TRIOBP	4.57e-04	226	55	4	25900982
Pubmed	Affinity purification strategies for proteomic analysis of transcription factor complexes.	CEBPE HNRNPUL2 PRPF8	4.97e-04	97	55	3	23937658
Pubmed	Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.	ATOH7 HES5	5.06e-04	21	55	2	17559664
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	SCAF1 FAM120A FMR1 HNRNPUL2 PRPF8	5.14e-04	417	55	5	36537216
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FMR1 ACLY PRPF8 PRDM16	5.20e-04	234	55	4	36243803
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	MRPL4 RANBP2 ACLY PRPF8	5.37e-04	236	55	4	36339263
Pubmed	Specification of SUMO1- and SUMO2-interacting motifs.	RANBP2 PIAS3	5.56e-04	22	55	2	16524884
Pubmed	Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.	PRDM16 HES5	5.56e-04	22	55	2	19050759
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	RANBP2 FAM120A FMR1 HNRNPUL2 PRPF8 SMYD3	5.78e-04	655	55	6	35819319
Pubmed	Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development.	ATOH7 HES5	6.08e-04	23	55	2	19191219
Pubmed	Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.	WDR81 PRPF8	6.63e-04	24	55	2	20705733
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	MRPL4 FAM120A FMR1 HNRNPUL2 LMO7 ACLY PRPF8	7.15e-04	949	55	7	36574265
Pubmed	Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.	ATOH7 HES5	7.20e-04	25	55	2	19389377
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	RANBP2 LMO7 ACLY PRPF8	7.28e-04	256	55	4	33397691
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	MEGF8 PTPRS SUSD2 CNTN1	7.39e-04	257	55	4	16335952
Pubmed	Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina.	ATOH7 HES5	7.79e-04	26	55	2	19828801
Pubmed	Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.	AGTPBP1 CNTN1	7.79e-04	26	55	2	35165395
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	FAM120A PIAS3 LMO7 RNF216	7.94e-04	262	55	4	36880596
Pubmed	Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.	ATOH7 HES5	8.40e-04	27	55	2	22323600
Pubmed	A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation.	IL17RD HES5	8.40e-04	27	55	2	22993445
Pubmed	Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.	ATOH7 HES5	8.40e-04	27	55	2	24148613
Pubmed	Notch pathway mutants do not equivalently perturb mouse embryonic retinal development.	ATOH7 HES5	9.04e-04	28	55	2	37751417
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	FAM120A FMR1 HNRNPUL2 ACLY PRPF8 SVEP1	9.04e-04	714	55	6	28302793
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	RANBP2 FAM120A ACLY PRPF8	9.12e-04	272	55	4	25315684
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	FAM120A FMR1 HNRNPUL2 LMO7	9.37e-04	274	55	4	34244482
Pubmed	Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina.	ATOH7 HES5	9.70e-04	29	55	2	19474320
Pubmed	Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation.	ATOH7 HES5	9.70e-04	29	55	2	25556712
Pubmed	Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation.	ACLY PRDM16	1.04e-03	30	55	2	31693883
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	SCAF1 RANBP2 RNF216 PRPF8	1.06e-03	283	55	4	18854154
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	FAM120A FMR1 HNRNPUL2 ACLY	1.08e-03	285	55	4	32838362
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 PWWP2A VPS18 FAM120A PRDM16	1.09e-03	493	55	5	15368895
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	RANBP2 FAM120A FMR1 WIPF1 AGTPBP1	1.13e-03	497	55	5	23414517
Pubmed	Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.	FAM120A HNRNPUL2 PRPF8	1.14e-03	129	55	3	28973437
Pubmed	Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.	PIAS3 SLC24A1	1.18e-03	32	55	2	19805139
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	CEBPE HNRNPUL2 PRPF8	1.19e-03	131	55	3	34551306
Pubmed	Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.	MRPL4 SCAF1 FMR1	1.27e-03	134	55	3	28695742
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SCAF1 FAM120A FMR1 LMO7 ACLY TRPM2 PRPF8 AGTPBP1	1.34e-03	1371	55	8	36244648
Pubmed	The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.	ATOH7 HES5	1.41e-03	35	55	2	28402857
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	HNRNPUL2 ACLY PRPF8	1.56e-03	144	55	3	35681168
Pubmed	The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation.	ACLY PRDM16	1.58e-03	37	55	2	35863637
Pubmed	The transcription factor XBP1 is selectively required for eosinophil differentiation.	CEBPE KLF2	1.58e-03	37	55	2	26147683
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SUSD1 SUSD2 SVEP1	2.14e-04	57	37	3	1179
Disease	platelet component distribution width	PRUNE2 PWWP2A VPS18 WIPF1 RAPGEF3 PRDM16 SVEP1	4.35e-04	755	54	7	EFO_0007984
Disease	retinitis pigmentosa (implicated_via_orthology)	PRPF8 AGTPBP1	1.12e-03	27	54	2	DOID:10584 (implicated_via_orthology)
Disease	Colorectal Carcinoma	VPS18 LMO7 PTPRS AGTPBP1 CNTN1 KLF2	1.74e-03	702	54	6	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
VFTEHPLLPFYPPEG	SLC4A3	846	P48751
PPPYVRTALHLFAGP	ADAD2	456	Q8NCV1
AFPHYLPPDPRPFAY	CEBPE	76	Q15744
RPFAYPPHTFGPDRK	CEBPE	86	Q15744
IPYNDFHVRGPPPVY	BPIFB4	61	P59827
PVRYPAENPRAHPDF	ARSI	501	Q5FYB1
IFLDATYHLPPPDPF	CHRNB1	486	P11230
PDLIVYGHFSPERPF	ADCY10	21	Q96PN6
VGSAAYLPDEPHPPF	DET1	156	Q7L5Y6
YLPDEPHPPFFEVYR	DET1	161	Q7L5Y6
YFGHIPPPFKEPILE	AGTPBP1	651	Q9UPW5
YNRLFDYHGRVPPPP	RALYL	136	Q86SE5
PEPGYFTKPPIAAHA	RANBP2	976	P49792
FVPFTPPEPYRFHPE	ITPRIP	211	Q8IWB1
EKQFVPFHPPPLRYR	IL17RD	561	Q8NFM7
VQRPLFPLPAAFYHP	NFU1	41	Q9UMS0
LPDLHPKGEYPPDLF	SLC24A1	431	O60721
LFHPPSDRPFIPYEL	JMJD7	196	P0C870
FLLYQHFRPTPEPPG	MAP3K6	481	O95382
RPDAPPEYNSHFLPG	PLSCR4	26	Q9NRQ2
FFPPPEEFVFIHAVP	HNRNPUL2	421	Q1KMD3
PPFVFQAPAPDYHLD	MEGF8	546	Q7Z7M0
VPLSGAPDRYHPVPF	LMO7	581	Q8WWI1
VPPPDFGTPTLHYFE	DSE	381	Q9UL01
SFHPPHYLAARPGPF	FAM120A	336	Q9NZB2
PDHGVPEYPTPFLAF	PTPRS	1556	Q13332
QIPFHDVRFPPPVGY	FMR1	41	Q06787
SFGYLDPFPPEERPE	CNTN1	131	Q12860
FGRDHYLPFPGAKLP	ATOH7	116	Q8N100
LDYGPPFQPPLHLEF	HHIPL2	46	Q6UWX4
DPPRGHKFFFEPVPE	CDH9	516	Q9ULB4
PPYGPHYPLFPLRDD	SPATA48	86	A4D263
YRPPRLASAFGDPHF	SUSD2	441	Q9UGT4
FHEGAPYPPPLFIRD	PWWP2A	266	Q96N64
ATRLENPGYFPHPDP	PRUNE2	1301	Q8WUY3
FSLPYSDFPRPLPHA	MRPL4	286	Q9BYD3
NEYFPSRPHPGSLPF	PRDM16	486	Q9HAZ2
LLFQHEFPGPAFPRP	RNF216	206	Q9NWF9
HPAFTPPYLFPIGDV	SVEP1	606	Q4LDE5
LYHFQRPPAAPAAPA	HES5	116	Q5TA89
EPYRIFFPGSHPVRG	SMYD3	356	Q9H7B4
RYLQHDPFPFFPEPR	TRIOBP	1031	Q9H2D6
TPPRFSFHHPYFLPG	SOX30	606	O94993
IEFPPPFGREAYPEE	ACLY	236	P53396
PPPFPGDPAHFLFRD	C11orf53	91	Q8IXP5
LRFFYSPPPGPEVVA	C11orf91	106	Q3C1V1
LPLHEYPPAFPLGAD	PIAS3	511	Q9Y6X2
RFSPIPFPPLSYKHD	PRPF8	821	Q6P2Q9
FYRFPGPEPEPVRTH	RAPGEF3	181	O95398
PAPRFDIYDPFHPTD	SCAF1	221	Q9H7N4
IEEYHGRPAAPPPFI	TRPM2	1071	O94759
YLPRNGPEPFHPTTD	SUSD1	156	Q6UWL2
GLFAAYTDHPPPFRE	VPS18	246	Q9P253
YTDHPPPFREFPSNL	VPS18	251	Q9P253
ESRFYFHPISDLPPP	WIPF1	451	O43516
EPELYLDPFCPPGFS	ZNF133	76	P52736
VPFPPYFPALHRFIL	WDR81	871	Q562E7
GYPPPEGEHDARVPF	ZSWIM4	86	Q9H7M6
LLQPPFFHPGYPRAV	KEL	556	P23276
YAPPAPPAFGLFDDA	KLF2	211	Q9Y5W3