Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium channel activity	CACNA1I CACNA1H GRIK1 GRIK2	1.39e-06	52	32	4	GO:0005272
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H	7.46e-06	3	32	2	GO:0008332
GeneOntologyMolecularFunction	scaffold protein binding	CACNA1H GRIK1 GRIK2 KARS1	1.43e-05	93	32	4	GO:0097110
GeneOntologyMolecularFunction	integrin binding involved in cell-matrix adhesion	ITGB1 SVEP1	2.48e-05	5	32	2	GO:0098640
GeneOntologyMolecularFunction	kainate selective glutamate receptor activity	GRIK1 GRIK2	3.72e-05	6	32	2	GO:0015277
GeneOntologyMolecularFunction	extracellularly glutamate-gated ion channel activity	GRIK1 GRIK2	5.20e-05	7	32	2	GO:0005234
GeneOntologyMolecularFunction	cell-matrix adhesion mediator activity	ITGB1 SVEP1	8.89e-05	9	32	2	GO:0098634
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	CACNA1I CACNA1H GRIK1 GRIK2	1.55e-04	171	32	4	GO:0015081
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1I CACNA1H	2.24e-04	14	32	2	GO:0008331
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIK1 GRIK2	3.33e-04	17	32	2	GO:0004970
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	GRIK1 GRIK2	3.75e-04	18	32	2	GO:0015280
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK1 GRIK2	6.72e-04	24	32	2	GO:0099507
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	CACNA1I CACNA1H	7.89e-04	26	32	2	GO:0005248
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK1 GRIK2	8.52e-04	27	32	2	GO:0008066
GeneOntologyMolecularFunction	calcium channel activity	CACNA1I CACNA1H GRIK1	1.14e-03	129	32	3	GO:0005262
GeneOntologyMolecularFunction	chemokine binding	CXCR6 ITGB1	1.27e-03	33	32	2	GO:0019956
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1I CACNA1H GRIK1	1.79e-03	151	32	3	GO:0015085
GeneOntologyMolecularFunction	gated channel activity	CACNA1I CACNA1H GRIK1 GRIK2	1.91e-03	334	32	4	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1I CACNA1H GRIK1 GRIK2	2.10e-03	343	32	4	GO:0005261
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	GRIK1 GRIK2	2.16e-03	43	32	2	GO:0005231
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1I CACNA1H	2.46e-03	46	32	2	GO:0005245
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRIK1 GRIK2	3.76e-03	57	32	2	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRIK1 GRIK2	4.16e-03	60	32	2	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRIK1 GRIK2	4.86e-03	65	32	2	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRIK1 GRIK2	4.86e-03	65	32	2	GO:0022824
GeneOntologyMolecularFunction	coreceptor activity	CXCR6 ITGB1	5.93e-03	72	32	2	GO:0015026
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1I CACNA1H GRIK1 GRIK2	5.95e-03	459	32	4	GO:0005216
GeneOntologyMolecularFunction	chromatin binding	GLI2 SVEP1 TLE4 NR5A2 CDC45	6.02e-03	739	32	5	GO:0003682
GeneOntologyMolecularFunction	amino acid binding	GRIK1 KARS1	6.09e-03	73	32	2	GO:0016597
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1I CACNA1H GRIK1 GRIK2	6.23e-03	465	32	4	GO:0046873
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIK1 GRIK2	6.42e-03	75	32	2	GO:0098960
GeneOntologyMolecularFunction	cell adhesion mediator activity	ITGB1 SVEP1	6.59e-03	76	32	2	GO:0098631
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GRIK1 GRIK2	6.75e-03	77	32	2	GO:0005230
GeneOntologyMolecularFunction	channel activity	CACNA1I CACNA1H GRIK1 GRIK2	9.48e-03	525	32	4	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1I CACNA1H GRIK1 GRIK2	9.54e-03	526	32	4	GO:0022803
GeneOntologyCellularComponent	sodium channel complex	CACNA1I CACNA1H GRIK1 GRIK2	9.16e-08	29	31	4	GO:0034706
GeneOntologyCellularComponent	cation channel complex	CACNA1I CACNA1H GRIK1 GRIK2 PDE4B	2.30e-05	235	31	5	GO:0034703
GeneOntologyCellularComponent	dendrite	PRKCG CACNA1H GRIK1 GRIK2 PDE4B KIF1A ITGB1 SIPA1L1	2.65e-05	858	31	8	GO:0030425
GeneOntologyCellularComponent	dendritic tree	PRKCG CACNA1H GRIK1 GRIK2 PDE4B KIF1A ITGB1 SIPA1L1	2.70e-05	860	31	8	GO:0097447
GeneOntologyCellularComponent	kainate selective glutamate receptor complex	GRIK1 GRIK2	3.18e-05	6	31	2	GO:0032983
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1I CACNA1H PDE4B	4.29e-05	46	31	3	GO:0005891
GeneOntologyCellularComponent	asymmetric synapse	PRKCG GRIK1 GRIK2 PDE4B ITGB1 SIPA1L1	6.20e-05	477	31	6	GO:0032279
GeneOntologyCellularComponent	postsynapse	PRKCG CACNA1H GRIK1 GRIK2 PDE4B KIF1A ITGB1 SIPA1L1	8.91e-05	1018	31	8	GO:0098794
GeneOntologyCellularComponent	neuron to neuron synapse	PRKCG GRIK1 GRIK2 PDE4B ITGB1 SIPA1L1	1.03e-04	523	31	6	GO:0098984
GeneOntologyCellularComponent	calcium channel complex	CACNA1I CACNA1H PDE4B	1.71e-04	73	31	3	GO:0034704
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1I CACNA1H GRIK1 GRIK2 PDE4B	2.17e-04	378	31	5	GO:0034702
GeneOntologyCellularComponent	voltage-gated sodium channel complex	CACNA1I CACNA1H	2.85e-04	17	31	2	GO:0001518
GeneOntologyCellularComponent	somatodendritic compartment	PRKCG CACNA1H GRIK1 GRIK2 PDE4B KIF1A ITGB1 SIPA1L1	3.25e-04	1228	31	8	GO:0036477
GeneOntologyCellularComponent	postsynaptic density	PRKCG GRIK1 GRIK2 PDE4B SIPA1L1	4.89e-04	451	31	5	GO:0014069
GeneOntologyCellularComponent	postsynaptic specialization	PRKCG GRIK1 GRIK2 PDE4B SIPA1L1	8.01e-04	503	31	5	GO:0099572
GeneOntologyCellularComponent	plasma membrane protein complex	CACNA1I CACNA1H GRIK1 GRIK2 PDE4B ITGB1	9.06e-04	785	31	6	GO:0098797
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1I CACNA1H GRIK1 GRIK2 PDE4B	9.54e-04	523	31	5	GO:1902495
GeneOntologyCellularComponent	transporter complex	CACNA1I CACNA1H GRIK1 GRIK2 PDE4B	1.19e-03	550	31	5	GO:1990351
GeneOntologyCellularComponent	synaptic membrane	PRKCG CACNA1H GRIK1 GRIK2 ITGB1	1.55e-03	583	31	5	GO:0097060
GeneOntologyCellularComponent	presynapse	PRKCG CACNA1H GRIK1 GRIK2 PDE4B KIF1A	1.69e-03	886	31	6	GO:0098793
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	GRIK1 GRIK2	2.03e-03	45	31	2	GO:0008328
GeneOntologyCellularComponent	neurotransmitter receptor complex	GRIK1 GRIK2	2.49e-03	50	31	2	GO:0098878
GeneOntologyCellularComponent	postsynaptic membrane	CACNA1H GRIK1 GRIK2 ITGB1	2.89e-03	405	31	4	GO:0045211
GeneOntologyCellularComponent	axon terminus	PRKCG GRIK1 GRIK2	3.65e-03	210	31	3	GO:0043679
GeneOntologyCellularComponent	neuron projection terminus	PRKCG GRIK1 GRIK2	4.88e-03	233	31	3	GO:0044306
GeneOntologyCellularComponent	dendritic spine	PDE4B ITGB1 SIPA1L1	5.42e-03	242	31	3	GO:0043197
GeneOntologyCellularComponent	neuron spine	PDE4B ITGB1 SIPA1L1	5.74e-03	247	31	3	GO:0044309
GeneOntologyCellularComponent	glutamatergic synapse	CACNA1H GRIK1 GRIK2 ITGB1 SIPA1L1	6.58e-03	817	31	5	GO:0098978
GeneOntologyCellularComponent	neuronal cell body	CACNA1H GRIK1 GRIK2 KIF1A SIPA1L1	7.20e-03	835	31	5	GO:0043025
GeneOntologyCellularComponent	presynaptic membrane	CACNA1H GRIK1 GRIK2	7.87e-03	277	31	3	GO:0042734
GeneOntologyCellularComponent	terminal bouton	GRIK1 GRIK2	8.90e-03	96	31	2	GO:0043195
GeneOntologyCellularComponent	potassium channel complex	GRIK1 GRIK2	1.04e-02	104	31	2	GO:0034705
GeneOntologyCellularComponent	cell-cell junction	PRKCG ITGB1 CDC42BPB SIPA1L3	1.09e-02	591	31	4	GO:0005911
GeneOntologyCellularComponent	excitatory synapse	PDE4B ITGB1	1.10e-02	107	31	2	GO:0060076
GeneOntologyCellularComponent	cell body	CACNA1H GRIK1 GRIK2 KIF1A SIPA1L1	1.11e-02	929	31	5	GO:0044297
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	GRIK2 KIF1A GLI2	1.13e-02	317	31	3	GO:0032838
GeneOntologyCellularComponent	neuron projection cytoplasm	GRIK2 KIF1A	1.16e-02	110	31	2	GO:0120111
GeneOntologyCellularComponent	actomyosin	CDC42BPB SIPA1L3	1.30e-02	117	31	2	GO:0042641
GeneOntologyCellularComponent	plasma membrane signaling receptor complex	GRIK1 GRIK2 ITGB1	1.48e-02	350	31	3	GO:0098802
GeneOntologyCellularComponent	cytoplasmic region	GRIK2 KIF1A GLI2	1.59e-02	360	31	3	GO:0099568
Domain	SPAR_C	SIPA1L1 SIPA1L3	8.52e-06	3	32	2	PF11881
Domain	SIPA1L_C	SIPA1L1 SIPA1L3	8.52e-06	3	32	2	IPR021818
Domain	VDCC_T_a1	CACNA1I CACNA1H	8.52e-06	3	32	2	IPR005445
Domain	Rap_GAP	SIPA1L1 SIPA1L3	1.27e-04	10	32	2	PF02145
Domain	VDCCAlpha1	CACNA1I CACNA1H	1.27e-04	10	32	2	IPR002077
Domain	Rap_GAP_dom	SIPA1L1 SIPA1L3	1.55e-04	11	32	2	IPR000331
Domain	RAPGAP	SIPA1L1 SIPA1L3	1.55e-04	11	32	2	PS50085
Domain	Iontro_rcpt	GRIK1 GRIK2	4.28e-04	18	32	2	IPR001320
Domain	Lig_chan	GRIK1 GRIK2	4.28e-04	18	32	2	PF00060
Domain	Lig_chan-Glu_bd	GRIK1 GRIK2	4.28e-04	18	32	2	PF10613
Domain	PBPe	GRIK1 GRIK2	4.28e-04	18	32	2	SM00079
Domain	Iono_rcpt_met	GRIK1 GRIK2	4.28e-04	18	32	2	IPR001508
Domain	Glu/Gly-bd	GRIK1 GRIK2	4.28e-04	18	32	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIK1 GRIK2	4.28e-04	18	32	2	SM00918
Domain	DAG/PE-bd	PRKCG CDC42BPB	5.85e-04	21	32	2	IPR020454
Domain	Pkinase_C	PRKCG CDC42BPB	1.82e-03	37	32	2	IPR017892
Domain	ANF_receptor	GRIK1 GRIK2	1.82e-03	37	32	2	PF01094
Domain	ANF_lig-bd_rcpt	GRIK1 GRIK2	1.82e-03	37	32	2	IPR001828
Domain	Peripla_BP_I	GRIK1 GRIK2	2.03e-03	39	32	2	IPR028082
Domain	Pkinase_C	PRKCG CDC42BPB	2.35e-03	42	32	2	PF00433
Domain	AGC-kinase_C	PRKCG CDC42BPB	4.13e-03	56	32	2	IPR000961
Domain	AGC_KINASE_CTER	PRKCG CDC42BPB	4.13e-03	56	32	2	PS51285
Domain	S_TK_X	PRKCG CDC42BPB	4.13e-03	56	32	2	SM00133
Domain	Channel_four-helix_dom	CACNA1I CACNA1H	4.28e-03	57	32	2	IPR027359
Domain	-	CACNA1I CACNA1H	4.28e-03	57	32	2	1.20.120.350
Domain	C1_1	PRKCG CDC42BPB	4.28e-03	57	32	2	PF00130
Domain	EGF_extracell	ITGB1 SVEP1	4.73e-03	60	32	2	IPR013111
Domain	EGF_2	ITGB1 SVEP1	4.73e-03	60	32	2	PF07974
Domain	ZF_DAG_PE_1	PRKCG CDC42BPB	5.37e-03	64	32	2	PS00479
Domain	ZF_DAG_PE_2	PRKCG CDC42BPB	5.37e-03	64	32	2	PS50081
Domain	C1	PRKCG CDC42BPB	5.53e-03	65	32	2	SM00109
Domain	PE/DAG-bd	PRKCG CDC42BPB	5.70e-03	66	32	2	IPR002219
Domain	-	ITGB1 SVEP1	7.11e-03	74	32	2	3.40.50.410
Domain	VWFA	ITGB1 SVEP1	8.67e-03	82	32	2	PS50234
Domain	VWA	ITGB1 SVEP1	9.08e-03	84	32	2	SM00327
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK1 GRIK2	1.14e-04	10	23	2	M10272
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK1 GRIK2	1.66e-04	12	23	2	MM15142
Pubmed	Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.	GRIK1 GRIK2	8.20e-07	2	32	2	12947409
Pubmed	Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.	GRIK1 GRIK2	8.20e-07	2	32	2	15537878
Pubmed	Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.	GRIK1 GRIK2	8.20e-07	2	32	2	15673679
Pubmed	Subunit composition of kainate receptors in hippocampal interneurons.	GRIK1 GRIK2	8.20e-07	2	32	2	11144357
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	8.20e-07	2	32	2	12808460
Pubmed	Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.	GRIK1 GRIK2	8.20e-07	2	32	2	25043179
Pubmed	Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus.	GRIK1 GRIK2	8.20e-07	2	32	2	11182092
Pubmed	Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.	GRIK1 GRIK2	8.20e-07	2	32	2	15928066
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	8.20e-07	2	32	2	25071191
Pubmed	Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.	GRIK1 GRIK2	8.20e-07	2	32	2	15358807
Pubmed	Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit.	GRIK1 GRIK2	8.20e-07	2	32	2	14724198
Pubmed	Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.	GRIK1 GRIK2	8.20e-07	2	32	2	8700852
Pubmed	The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones.	GRIK1 GRIK2	8.20e-07	2	32	2	15539395
Pubmed	Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.	GRIK1 GRIK2	8.20e-07	2	32	2	24760837
Pubmed	Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.	SIPA1L1 SIPA1L3	8.20e-07	2	32	2	26364583
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	8.20e-07	2	32	2	36786913
Pubmed	A mosaic of functional kainate receptors in hippocampal interneurons.	GRIK1 GRIK2	8.20e-07	2	32	2	15483117
Pubmed	Functional characterization of kainate receptors in the mouse nucleus accumbens.	GRIK1 GRIK2	8.20e-07	2	32	2	11985817
Pubmed	RNA editing of human kainate receptor subunits.	GRIK1 GRIK2	8.20e-07	2	32	2	7696618
Pubmed	Q/R site editing controls kainate receptor inhibition by membrane fatty acids.	GRIK1 GRIK2	8.20e-07	2	32	2	16221857
Pubmed	Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice.	GRIK1 GRIK2	8.20e-07	2	32	2	16219388
Pubmed	Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.	GRIK1 GRIK2	8.20e-07	2	32	2	8260617
Pubmed	Subunit composition and alternative splicing regulate membrane delivery of kainate receptors.	GRIK1 GRIK2	8.20e-07	2	32	2	15014126
Pubmed	Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus.	GRIK1 GRIK2	8.20e-07	2	32	2	11069933
Pubmed	The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.	GRIK1 GRIK2	2.46e-06	3	32	2	31513786
Pubmed	Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations.	GRIK1 GRIK2	2.46e-06	3	32	2	15509753
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1H	2.46e-06	3	32	2	23488970
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1H	2.46e-06	3	32	2	26488564
Pubmed	Differential trafficking of GluR7 kainate receptor subunit splice variants.	GRIK1 GRIK2	2.46e-06	3	32	2	15805114
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1H	2.46e-06	3	32	2	18591418
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1H	2.46e-06	3	32	2	11230107
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1H	2.46e-06	3	32	2	11897840
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1H	2.46e-06	3	32	2	28846697
Pubmed	Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.	GRIK1 GRIK2	2.46e-06	3	32	2	27346345
Pubmed	Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel.	GRIK1 GRIK2	2.46e-06	3	32	2	1379666
Pubmed	Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.	GRIK1 GRIK2	2.46e-06	3	32	2	8730589
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1H	2.46e-06	3	32	2	33547341
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1H	2.46e-06	3	32	2	28972185
Pubmed	RapGAPs in brain: multipurpose players in neuronal Rap signalling.	SIPA1L1 SIPA1L3	2.46e-06	3	32	2	20576033
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1H	2.46e-06	3	32	2	11927664
Pubmed	RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.	GRIK1 GRIK2	2.46e-06	3	32	2	7523595
Pubmed	Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice.	GRIK1 GRIK2	2.46e-06	3	32	2	9880586
Pubmed	Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons.	GRIK1 GRIK2	4.92e-06	4	32	2	17650106
Pubmed	The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.	GRIK1 GRIK2	4.92e-06	4	32	2	26277340
Pubmed	Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.	GRIK1 GRIK2	4.92e-06	4	32	2	15513934
Pubmed	Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses.	GRIK1 GRIK2	4.92e-06	4	32	2	20081851
Pubmed	Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.	GRIK1 GRIK2	4.92e-06	4	32	2	30241548
Pubmed	Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses.	GRIK1 GRIK2	4.92e-06	4	32	2	16354929
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1H	4.92e-06	4	32	2	28165634
Pubmed	Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.	GRIK1 GRIK2	4.92e-06	4	32	2	19369569
Pubmed	Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain.	GRIK1 GRIK2	4.92e-06	4	32	2	25556835
Pubmed	The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1.	ITGB1 SVEP1	4.92e-06	4	32	2	35802072
Pubmed	Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17.	GRIK1 GRIK2	4.92e-06	4	32	2	17174564
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CACNA1H ANKMY1 GRIK1 GRIK2 KIF1A ITGB1 CDC42BPB GLI2 SIPA1L3	5.41e-06	1489	32	9	28611215
Pubmed	Developmental expression patterns of kainate receptors in the mouse spinal cord.	GRIK1 GRIK2	8.19e-06	5	32	2	23076118
Pubmed	Kainate receptors: pharmacology, function and therapeutic potential.	GRIK1 GRIK2	8.19e-06	5	32	2	18793656
Pubmed	Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.	GRIK1 GRIK2	8.19e-06	5	32	2	28228252
Pubmed	Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.	GRIK1 GRIK2	8.19e-06	5	32	2	12223554
Pubmed	RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.	GRIK1 GRIK2	8.19e-06	5	32	2	1717158
Pubmed	Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.	GRIK1 GRIK2	8.19e-06	5	32	2	28854365
Pubmed	Polydom/SVEP1 is a ligand for integrin α9β1.	ITGB1 SVEP1	8.19e-06	5	32	2	22654117
Pubmed	Molecular determinants of kainate receptor trafficking.	GRIK1 GRIK2	8.19e-06	5	32	2	18358623
Pubmed	Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.	GRIK1 GRIK2	8.19e-06	5	32	2	9593973
Pubmed	Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.	GRIK1 GRIK2	8.19e-06	5	32	2	29058671
Pubmed	Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.	GRIK1 GRIK2	1.23e-05	6	32	2	12597860
Pubmed	N-glycan content modulates kainate receptor functional properties.	GRIK1 GRIK2	1.23e-05	6	32	2	28714086
Pubmed	Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5.	PRKCG GRIK1	1.23e-05	6	32	2	20359526
Pubmed	Delayed cortical development in mice with a neural specific deletion of β1 integrin.	ITGB1 TLE4	1.23e-05	6	32	2	37250402
Pubmed	Neto1 is an auxiliary subunit of native synaptic kainate receptors.	GRIK1 GRIK2	1.23e-05	6	32	2	21734292
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	KIF1A ITGB1 CDC42BPB CDC45	1.40e-05	160	32	4	31678930
Pubmed	Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.	GRIK1 GRIK2	1.72e-05	7	32	2	17428973
Pubmed	Glutamate receptors in cortical plasticity: molecular and cellular biology.	GRIK1 GRIK2	1.72e-05	7	32	2	9016303
Pubmed	Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.	GRIK1 GRIK2	1.72e-05	7	32	2	19342380
Pubmed	Glutamate receptors: brain function and signal transduction.	GRIK1 GRIK2	1.72e-05	7	32	2	9651535
Pubmed	Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.	GRIK1 GRIK2	1.72e-05	7	32	2	1310861
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	CACNA1H GRIK1 PDE4B GLI2	1.82e-05	171	32	4	20201926
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1I CACNA1H	2.29e-05	8	32	2	28330839
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1I CACNA1H	2.29e-05	8	32	2	34478646
Pubmed	Transmembrane topology of the glutamate receptor subunit GluR6.	GRIK1 GRIK2	2.29e-05	8	32	2	8163463
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1I CACNA1H	2.29e-05	8	32	2	12761855
Pubmed	Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.	GRIK1 GRIK2	2.94e-05	9	32	2	34100982
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1I CACNA1H	2.94e-05	9	32	2	16382099
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIK1 GRIK2	2.94e-05	9	32	2	9051806
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1I CACNA1H	3.67e-05	10	32	2	24778262
Pubmed	The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.	GRIK1 GRIK2	5.38e-05	12	32	2	11891216
Pubmed	Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.	PRKCG GRIK2	6.36e-05	13	32	2	18641643
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GRIK1 GRIK2	6.36e-05	13	32	2	20859245
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	ITGB1 GLI2	7.41e-05	14	32	2	19783738
Pubmed	DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.	GRIK2 TLE4	8.55e-05	15	32	2	25556833
Pubmed	MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development.	ITGB1 GLI2	9.76e-05	16	32	2	30250269
Pubmed	Cooperative activity of noggin and gremlin 1 in axial skeleton development.	PRKCG GLI2	1.39e-04	19	32	2	21303853
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	KARS1 ITGB1 SIPA1L3	1.76e-04	118	32	3	27377895
Pubmed	Identification of Modifier Genes in a Mouse Model of Gaucher Disease.	GRIK2 MAMDC2	1.87e-04	22	32	2	27568557
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	CNOT2 SIPA1L1 SIPA1L3	1.94e-04	122	32	3	30773093
Pubmed	Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.	GRIK1 GRIK2	2.05e-04	23	32	2	8464923
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PRKCG GRIK2 PDE4B CDC42BPB SIPA1L1 SIPA1L3	2.17e-04	963	32	6	28671696
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIK1 GRIK2	2.24e-04	24	32	2	35746896
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	GRIK1 GRIK2	2.24e-04	24	32	2	22534482
Pubmed	Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis.	GLI2 TLE4	2.63e-04	26	32	2	26387942
Pubmed	Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.	CXCR6 ITGB1	3.28e-04	29	32	2	23708969
Cytoband	2q37.3	ANKMY1 KIF1A	1.33e-03	77	32	2	2q37.3
GeneFamily	Glutamate ionotropic receptor kainate type subunits	GRIK1 GRIK2	1.54e-05	5	23	2	1199
GeneFamily	Calcium voltage-gated channel subunits	CACNA1I CACNA1H	4.94e-04	26	23	2	253
GeneFamily	PDZ domain containing	SIPA1L1 SIPA1L3	1.58e-02	152	23	2	1220
Coexpression	GSE6681_DELETED_FOXP3_VS_WT_TREG_UP	TMEM45B RNF17 CXCR6 MAMDC2 CDC45	4.09e-06	199	32	5	M6777
Coexpression	GSE40274_CTRL_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_UP	HACD4 CXCR6 ITGB1 CNOT2	4.21e-05	160	32	4	M9111
Coexpression	GSE22886_NEUTROPHIL_VS_MONOCYTE_UP	GRIK2 ADGRG3 RNF17 NR5A2	9.44e-05	197	32	4	M4466
Coexpression	GSE22886_NEUTROPHIL_VS_DC_UP	GRIK1 ADGRG3 PDE4B NR5A2	9.81e-05	199	32	4	M4464
Coexpression	GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_UP	ADGRG3 PDE4B TLE4 SIPA1L1	9.81e-05	199	32	4	M5357
Coexpression	GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN	ADGRG3 RNF17 ABTB2 SIPA1L1	1.00e-04	200	32	4	M9496
Coexpression	GSE14769_20MIN_VS_360MIN_LPS_BMDM_DN	PRKCG KARS1 SFSWAP SIPA1L1	1.00e-04	200	32	4	M3513
Coexpression	BOYLAN_MULTIPLE_MYELOMA_PCA3_UP	GRIK1 CDC42BPB ABTB2	1.37e-04	82	32	3	M18227
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HACD4 MAMDC2 GLI2 ABTB2 SVEP1	2.40e-07	191	32	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ELOVL3 MAMDC2 GLI2 SVEP1	4.76e-06	157	32	4	f147e24f2ece82e1c54750868954d09b3c461804
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2_(Retrosplenial_cortex_(RSG)/Subiculum/Parasubiculum)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ELOVL3 ANKMY1 CXCR6	5.53e-06	48	32	3	e96a608c2239f2ceb07d0a492289b24fabf190a1
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2_(Retrosplenial_cortex_(RSG)/Subiculum/Parasubiculum)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ELOVL3 ANKMY1 CXCR6	5.53e-06	48	32	3	17cb229b199c49ec74d2230b1f8dbb0195b1bf01
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2_(Retrosplenial_cortex_(RSG)/Subiculum/Parasubiculum)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ELOVL3 ANKMY1 CXCR6	5.53e-06	48	32	3	c030dfb7c3289df7f34e91f31be6e9b47ca045f5
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRKCG GRIK1 GRIK2 KIF1A	6.36e-06	169	32	4	96a2aec9acf8a6f966973c035e5ade456cf47772
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))--\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADGRG3 GAPDHS MEIOC	9.32e-06	57	32	3	9614fe2acc6ee039383504f94bbe6d35aac27f25
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADGRG3 GAPDHS MEIOC	9.32e-06	57	32	3	3c55a5598a7ea789500f2fbd35c79d2b97a3fc7d
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))\|Thalamus / BrainAtlas - Mouse McCarroll V32	ADGRG3 GAPDHS MEIOC	9.32e-06	57	32	3	309b3d48bfe215d7b581722c06d444b5b2ef6a30
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	MAMDC2 GLI2 ABTB2 SVEP1	9.49e-06	187	32	4	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	15-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	GRIK1 PDE4B MAMDC2 ABTB2	1.03e-05	191	32	4	409e12d2bb26b6d2ed025304ca6ace07df16638a
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	ELOVL3 PDE4B MEIOC NR5A2	1.19e-05	198	32	4	3c3a5d2555f6af4aa33f9ea778808315d0e39d86
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 PDE4B ABTB2	1.24e-05	200	32	4	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 PDE4B ABTB2	1.24e-05	200	32	4	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIK1 GRIK2 PDE4B ABTB2	1.24e-05	200	32	4	9719fabddc34051949468a7520289e3c750de4f8
ToppCell	Control-Endothelial-Endothelial-Activated_Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ELOVL3 MEIOC NR5A2	8.89e-05	121	32	3	a5962d1c476e6966870832b72d511607e047248b
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAMDC2 GLI2 SVEP1	9.79e-05	125	32	3	b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK2 CXCR6 SVEP1	1.10e-04	130	32	3	e5acaa9aaa22b10d11410e2c01647b31354c21ed
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK2 CXCR6 SVEP1	1.31e-04	138	32	3	d5342383c5e52b92c39d7afe76560501be3ea5cd
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK2 CXCR6 SVEP1	1.31e-04	138	32	3	e2659949944bdf39b23c7275e380a7a937e2726c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCG GLI2 SVEP1	1.52e-04	145	32	3	051d964ff6bdc12ba3f0459d3e6ab16fa9507b0b
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PRKCG CACNA1I CACNA1H	1.58e-04	147	32	3	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	Adult-Mesenchymal-chondrocyte-D122\|Adult / Lineage, Cell type, age group and donor	MAMDC2 GLI2 SVEP1	1.61e-04	148	32	3	81a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCell	Lymphoid-Lymphoid-NK_cells\|Lymphoid / shred on cell class and cell subclass (v4)	ADGRG3 CXCR6 ITGB1	1.61e-04	148	32	3	d51a4b654a88d58dcdf29c2bc362c0cc1c40723a
ToppCell	368C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ANKMY1 BNIPL CDC45	1.68e-04	150	32	3	c3ad5fa41eb636a5d691c0268c0f1c32cd0de658
ToppCell	368C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ANKMY1 BNIPL CDC45	1.68e-04	150	32	3	78b8029e71d26f336a46274c8afef3435bf536b9
ToppCell	droplet-Lung-nan-3m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF17 KIF1A CDC45	1.74e-04	152	32	3	77b319f594d5e4df29034bbf69c7490076f89dd3
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HACD4 MEIOC CXCR6	1.74e-04	152	32	3	5adcdf93fd3ca066402aaaf308c363e4648f871d
ToppCell	PND07-28-samps-Lymphocyte-T_cells\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ADGRG3 CXCR6 CDC45	1.92e-04	157	32	3	f3b4cde52423246ae6fc4924cd1ee502cf6c009c
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ELOVL3 MAMDC2 SVEP1	1.96e-04	158	32	3	e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCell	COPD-Epithelial-PNEC\|COPD / Disease state, Lineage and Cell class	CACNA1H GRIK2 KIF1A	1.99e-04	159	32	3	6018124980c55190928409f3bf41d846a118954a
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	MAMDC2 GLI2 SVEP1	1.99e-04	159	32	3	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	COPD-Epithelial-PNEC\|World / Disease state, Lineage and Cell class	CACNA1H GRIK2 KIF1A	2.03e-04	160	32	3	cdea93317b0ebb801ddbe73bca6149ce2c727f16
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-Cajal-Retzius\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PDE4B ABTB2 SVEP1	2.10e-04	162	32	3	1f589a763f3fd4e1e612809ef3903879d47dc1d8
ToppCell	368C-Fibroblasts-Fibroblast-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	MAMDC2 SVEP1 CDC45	2.10e-04	162	32	3	e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell	368C-Fibroblasts-Fibroblast-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	MAMDC2 SVEP1 CDC45	2.10e-04	162	32	3	ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Cajal-Retzius\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	PDE4B ABTB2 SVEP1	2.14e-04	163	32	3	c1484e4de8b10e2f5fb14a7c02b2a015ffe0305e
ToppCell	-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	PDE4B MAMDC2 SVEP1	2.18e-04	164	32	3	2d65f025f921a5327bfd8d260815baaed00ef3fa
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I GRIK1 BNIPL	2.26e-04	166	32	3	6a948aefd283a2572da37b59dbc142b6e686b024
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I GRIK1 BNIPL	2.26e-04	166	32	3	8d0c4eb90a2c006f96ae61d3d94c96fb64bc0c4d
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1H GRIK2 KIF1A	2.30e-04	167	32	3	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	facs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOVL3 GRIK2 SVEP1	2.30e-04	167	32	3	3e3d8f6df2feefafad5b44ba0ebf5b5a0fe4ed58
ToppCell	facs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOVL3 GRIK2 SVEP1	2.30e-04	167	32	3	3ad9f3122dbe96580f640388ef920ea209fc2349
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_NK-NK_CD56bright_CD16-\|GI_small-bowel / Manually curated celltypes from each tissue	ADGRG3 GAPDHS ITGB1	2.30e-04	167	32	3	7ff186b2bed3b0de93addb3b0ae5a2c6e44ddfb2
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1H CXCR6 CDC45	2.30e-04	167	32	3	859dfe0764cb69de27e79e1c1aa65f9d538f79ea
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GRIK2 PDE4B KIF1A	2.38e-04	169	32	3	d9c3b22f62b882b8a2ea6fd9cf7afbe6d1775745
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-6\|TCGA-Liver / Sample_Type by Project: Shred V9	HACD4 MAMDC2 SVEP1	2.38e-04	169	32	3	e992530776cab922d0360b275fb9cb8bd0017b06
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1H GLI2 SVEP1	2.38e-04	169	32	3	c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GRIK1 ITGB1 SVEP1	2.38e-04	169	32	3	01a24a8817628125bd004b2be68ffa62c7111f6e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GAPDHS GLI2 SVEP1	2.47e-04	171	32	3	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GAPDHS GLI2 SVEP1	2.47e-04	171	32	3	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1H GLI2 SVEP1	2.47e-04	171	32	3	20ac3de9c164b409b70a30a8b6544ea491ef7c0e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIK2 GLI2 SVEP1	2.60e-04	174	32	3	9c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIK2 GLI2 SVEP1	2.60e-04	174	32	3	bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	GRIK2 GAPDHS KIF1A	2.64e-04	175	32	3	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PRKCG CACNA1H CXCR6	2.64e-04	175	32	3	6374ab186d7ccf7f6dfb858267edba8962789e15
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma-4\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	CACNA1I CNOT2 SVEP1	2.64e-04	175	32	3	16849ea8f0985108baa2085f34c3de14a4f9f28b
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	GRIK2 GAPDHS KIF1A	2.64e-04	175	32	3	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-progenitor-Germ\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ELOVL3 CACNA1I RNF17	2.69e-04	176	32	3	eea554ea75580f8dd5fefb57e7f33441ab86b884
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-progenitor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ELOVL3 CACNA1I RNF17	2.69e-04	176	32	3	d5cee483d2a60f82fdc67ad447b589d022fe8c97
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GRIK2 PDE4B KIF1A	2.78e-04	178	32	3	38ffbd01230c99f52274424ee6c172381daffc73
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MAMDC2 GLI2 SVEP1	2.78e-04	178	32	3	e32f5ed7a492edfa7073416008b1fcfae6b854ad
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GRIK2 PDE4B KIF1A	2.82e-04	179	32	3	df6d2cdc4e204ce1a4628dc71dfbc5e6c6309b2a
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1H GRIK2 KIF1A	2.82e-04	179	32	3	f93e81a3fd94adedb24a9db4ac1d53e275bbf8b5
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1H GRIK2 KIF1A	2.82e-04	179	32	3	878b15ea62e3405682a538f79f58d74b9cd3f398
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HACD4 MAMDC2 GLI2	2.82e-04	179	32	3	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	390C-Fibroblasts-Fibroblast-G\|390C / Donor, Lineage, Cell class and subclass (all cells)	MAMDC2 GLI2 SVEP1	2.87e-04	180	32	3	137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAMDC2 GLI2 SVEP1	2.87e-04	180	32	3	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAMDC2 GLI2 SVEP1	2.87e-04	180	32	3	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	390C-Fibroblasts-Fibroblast-G-\|390C / Donor, Lineage, Cell class and subclass (all cells)	MAMDC2 GLI2 SVEP1	2.87e-04	180	32	3	cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAMDC2 GLI2 SVEP1	2.91e-04	181	32	3	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	18-Airway-Epithelial-Submucosal_gland_basal\|Airway / Age, Tissue, Lineage and Cell class	GRIK1 PDE4B ABTB2	2.91e-04	181	32	3	33938e6521712058312879f84f4ae381c2bfc379
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GRIK2 PDE4B KIF1A	2.96e-04	182	32	3	b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	GRIK1 GRIK2 KIF1A	3.01e-04	183	32	3	8820cfed27b292bc0bc9cde4005219ed41900552
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GRIK2 PDE4B KIF1A	3.01e-04	183	32	3	f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAMDC2 GLI2 ABTB2	3.01e-04	183	32	3	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	lymphoid-NK_cell-TNFRSF18+IL7R-_NK_cell\|lymphoid / Lineage, cell class and subclass	ADGRG3 CXCR6 ITGB1	3.06e-04	184	32	3	62a3918705a3fcf3ef25c9ceb80f575a2e56ef76
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIK1 ADGRG3 PDE4B	3.06e-04	184	32	3	30ca56d64c961127e26122613e35aa2b46fde2df
ToppCell	Control-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	ADGRG3 CNOT2 SIPA1L1	3.11e-04	185	32	3	520795866d44def5be3910ce8e728045c716a24d
ToppCell	Control-Lymphoid-ILC_A\|World / Disease state, Lineage and Cell class	ADGRG3 CXCR6 CNOT2	3.16e-04	186	32	3	7bc939bf4e71bb4c6409b862c1f6c547d775e089
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK1 GRIK2 MAMDC2	3.16e-04	186	32	3	ea936e66ae4b7b40564711fad60ac0137327995f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK1 GRIK2 MAMDC2	3.16e-04	186	32	3	d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 PDE4B CXCR6	3.21e-04	187	32	3	42b20d7f0a4f9195b3d71dc0e089b5e0914ebcbb
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIK2 PDE4B KIF1A	3.21e-04	187	32	3	dfc2b95d70daf533bc0cc4ce78af9f65dd75a25b
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CACNA1I ABTB2 TLE4	3.21e-04	187	32	3	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI2 SVEP1 CDC45	3.21e-04	187	32	3	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK1 GRIK2 MAMDC2	3.21e-04	187	32	3	a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCell	PCW_05-06-Neuronal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GRIK2 PDE4B KIF1A	3.21e-04	187	32	3	03a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GLI2 SVEP1 CDC45	3.21e-04	187	32	3	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 GRIK2 SVEP1	3.21e-04	187	32	3	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK1 GRIK2 MAMDC2	3.21e-04	187	32	3	f2af79a20438108c814a73f9e24cd986d537237f
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE4B TLE4 SIPA1L1	3.26e-04	188	32	3	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGB1 GLI2 ABTB2	3.26e-04	188	32	3	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-chondrocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GRIK2 GLI2 SVEP1	3.26e-04	188	32	3	c9270517e6940e9793586f67f02431210552f278
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HACD4 GLI2 ABTB2	3.31e-04	189	32	3	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	T_cells-Effector_memory_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CACNA1I PDE4B CXCR6	3.36e-04	190	32	3	13dc3a0aaa554f63eabac37726bd1f11b66fb3dd
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK1 GRIK2 MAMDC2	3.36e-04	190	32	3	ff3dec5b45c6ea9b5319fb51a0198c6773b7be26
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CXCR6 ITGB1 NR5A2	3.36e-04	190	32	3	ce049630ed69d31f00acbc1b5b0896efc592121f
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE4B MAMDC2 SIPA1L1	3.36e-04	190	32	3	2d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	MAMDC2 GLI2 SVEP1	3.36e-04	190	32	3	3a42a9b98d954685d38a741f44545898d0e3e9ce
Drug	5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime	GRIK1 GRIK2	1.91e-06	2	32	2	ctd:C084273
Drug	LY382884	GRIK1 GRIK2 KARS1	2.41e-06	19	32	3	CID000656723
Drug	NS 102	GRIK1 GRIK2 KARS1	3.81e-06	22	32	3	CID005282252
Drug	compound 30	CACNA1I CACNA1H PDE4B	3.81e-06	22	32	3	CID005492232
Drug	SureCN2398996	CACNA1I CACNA1H	5.74e-06	3	32	2	CID010220069
Drug	N-desmethylmethsuximide	CACNA1I CACNA1H	5.74e-06	3	32	2	CID000092154
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1I CACNA1H	5.74e-06	3	32	2	CID010679219
Drug	Trimethobenzamide hydrochloride [554-92-7]; Down 200; 9.4uM; PC3; HT_HG-U133A	CACNA1I GLI2 SVEP1 TLE4 NR5A2	7.49e-06	196	32	5	4100_DN
Drug	Methylergometrine maleate [113-42-8]; Up 200; 8.8uM; MCF7; HT_HG-U133A	CACNA1I ANKMY1 CXCR6 TLE4 SIPA1L1	8.26e-06	200	32	5	3222_UP
Drug	LY293558	GRIK1 GRIK2 KARS1	9.98e-06	30	32	3	CID000127894
Drug	caffeine	CACNA1I CACNA1H GRIK1 GRIK2 PDE4B CNOT2 CDC45	1.06e-05	562	32	7	CID000002519
Drug	4-methylglutamic acid	GRIK1 GRIK2 KARS1	1.10e-05	31	32	3	CID000005365
Drug	methsuximide	CACNA1I CACNA1H	1.15e-05	4	32	2	CID000006476
Drug	AC1O7G5C	CACNA1I CACNA1H	1.91e-05	5	32	2	CID006603942
Drug	phensuximide	CACNA1I CACNA1H	1.91e-05	5	32	2	CID000006839
Drug	Flunarizine	CACNA1I CACNA1H	1.91e-05	5	32	2	DB04841
Drug	AC1MQ5W8	CACNA1I CACNA1H	2.86e-05	6	32	2	CID003396482
Drug	cerebrocrast	CACNA1I CACNA1H	2.86e-05	6	32	2	CID000159556
Drug	3,4-dihydroquinazoline	CACNA1I CACNA1H	2.86e-05	6	32	2	CID000583065
Drug	philanthotoxin	GRIK1 GRIK2 KARS1	3.44e-05	45	32	3	CID000115201
Drug	LY215840	CACNA1I CACNA1H	4.00e-05	7	32	2	CID000132049
Drug	losigamone	CACNA1I CACNA1H	4.00e-05	7	32	2	CID000060572
Drug	AC1L1B65	GRIK1 KARS1	5.33e-05	8	32	2	CID000001300
Drug	Cinnarizine	CACNA1I CACNA1H	6.85e-05	9	32	2	DB00568
Drug	1m5b	GRIK1 GRIK2	6.85e-05	9	32	2	CID000447081
Drug	LY339434	GRIK1 GRIK2	6.85e-05	9	32	2	CID006324635
Drug	NS3763	GRIK1 KARS1	6.85e-05	9	32	2	CID004359312
Drug	Landel	CACNA1I CACNA1H	6.85e-05	9	32	2	CID000163838
Drug	Colforsin	CACNA1I CACNA1H PDE4B ITGB1 NR5A2	7.28e-05	315	32	5	ctd:D005576
Drug	GYKI 52466	GRIK1 GRIK2 KARS1	7.38e-05	58	32	3	CID000003538
Drug	Dinoprost trometamol [38362-01-5]; Up 200; 8.4uM; HL60; HT_HG-U133A	CACNA1I ADGRG3 PDE4B SIPA1L1	8.36e-05	166	32	4	2446_UP
Drug	ZD7288	CACNA1I CACNA1H	8.55e-05	10	32	2	CID000123983
Drug	Benzoates	GRIK1 GRIK2	8.55e-05	10	32	2	ctd:D001565
Drug	riluzole	CACNA1I CACNA1H GRIK1 GRIK2	1.00e-04	174	32	4	CID000005070
Drug	Mibefradil	CACNA1I CACNA1H	1.04e-04	11	32	2	DB01388
Drug	EBNs	CACNA1I CACNA1H	1.04e-04	11	32	2	CID000150695
Drug	arachidonoylglycine	CACNA1I CACNA1H	1.04e-04	11	32	2	CID000004345
Drug	AC1L2VU3	CACNA1I CACNA1H	1.25e-04	12	32	2	CID000129572
Drug	themisone	CACNA1I CACNA1H	1.25e-04	12	32	2	CID000016235
Drug	guanosine 3',5'-cyclic monophosphoric acid	PRKCG CACNA1I CACNA1H GRIK1 PDE4B RNF17	1.33e-04	577	32	6	CID000000295
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A	CACNA1H ANKMY1 SVEP1 TLE4	1.44e-04	191	32	4	7417_UP
Drug	tetralol	CACNA1I CACNA1H	1.48e-04	13	32	2	CID000010747
Drug	Mibefradil	CACNA1I CACNA1H	1.48e-04	13	32	2	ctd:D020748
Drug	Altretamine [654-05-6]; Down 200; 19uM; MCF7; HT_HG-U133A	PDE4B ITGB1 SIPA1L1 SIPA1L3	1.52e-04	194	32	4	6467_DN
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	CACNA1H ANKMY1 TLE4 SIPA1L3	1.52e-04	194	32	4	3316_DN
Drug	Dichlorphenamide [120-97-8]; Up 200; 13.2uM; MCF7; HT_HG-U133A	PDE4B RNF17 CXCR6 SVEP1	1.55e-04	195	32	4	3366_UP
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; PC3; HT_HG-U133A	CACNA1I KIF1A TLE4 NR5A2	1.55e-04	195	32	4	4312_UP
Drug	Progesterone [57-83-0]; Up 200; 12.8uM; HL60; HT_HG-U133A	CACNA1I ADGRG3 KIF1A SVEP1	1.55e-04	195	32	4	2426_UP
Drug	Dimethadione [695-53-4]; Up 200; 31uM; HL60; HT_HG-U133A	ANKMY1 GRIK1 CXCR6 ABTB2	1.59e-04	196	32	4	3029_UP
Drug	Dipivefrin hydrochloride [64019-93-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	SFSWAP ITGB1 CDC42BPB SIPA1L3	1.59e-04	196	32	4	7124_DN
Drug	Bicuculline (+) [485-49-4]; Down 200; 10.8uM; PC3; HT_HG-U133A	GRIK2 KIF1A ITGB1 SIPA1L3	1.59e-04	196	32	4	4574_DN
Drug	Terconazole [67915-31-5]; Up 200; 7.6uM; MCF7; HT_HG-U133A	CACNA1I CACNA1H RNF17 SVEP1	1.59e-04	196	32	4	4407_UP
Drug	Flurandrenolide [1524-88-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A	CACNA1H KIF1A ABTB2 SIPA1L3	1.62e-04	197	32	4	4702_DN
Drug	Salbutamol [18559-94-9]; Down 200; 16.8uM; MCF7; HT_HG-U133A	CACNA1H ANKMY1 ITGB1 SIPA1L3	1.62e-04	197	32	4	2306_DN
Drug	Orlistat; Up 200; 10uM; MCF7; HT_HG-U133A	CACNA1H RNF17 ITGB1 NR5A2	1.62e-04	197	32	4	6383_UP
Drug	Sulfameter [651-06-9]; Up 200; 14.2uM; HL60; HT_HG-U133A	KIF1A ABTB2 SIPA1L3 NR5A2	1.62e-04	197	32	4	2712_UP
Drug	aspirin, USP; Up 200; 100uM; PC3; HT_HG-U133A	GRIK2 RNF17 KIF1A GLI2	1.65e-04	198	32	4	4428_UP
Drug	Demecarium bromide [56-94-0]; Up 200; 5.6uM; PC3; HT_HG-U133A	KIF1A CXCR6 SVEP1 NR5A2	1.68e-04	199	32	4	5795_UP
Drug	Carbetapentane citrate [23142-01-0]; Up 200; 7.6uM; PC3; HT_HG-U133A	KIF1A CXCR6 GLI2 NR5A2	1.68e-04	199	32	4	4649_UP
Drug	Yohimbinic acid monohydrate [27801-27-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	CACNA1I GRIK2 SVEP1 TLE4	1.71e-04	200	32	4	4082_DN
Drug	Eucatropine hydrochloride [536-93-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	CACNA1I ANKMY1 PDE4B SVEP1	1.71e-04	200	32	4	3935_UP
Drug	Tobramycin [32986-56-4]; Up 200; 8.6uM; HL60; HT_HG-U133A	CACNA1I KIF1A CXCR6 SIPA1L1	1.71e-04	200	32	4	2481_UP
Drug	butamben	CACNA1I CACNA1H	1.99e-04	15	32	2	CID000002482
Drug	pentasulfane	CACNA1I CACNA1H	2.27e-04	16	32	2	CID000448216
Drug	decahydroisoquinoline	GRIK1 GRIK2	2.27e-04	16	32	2	CID000097812
Drug	efonidipine	CACNA1I CACNA1H	2.57e-04	17	32	2	CID000119170
Drug	Zonisamide	CACNA1I CACNA1H	2.57e-04	17	32	2	DB00909
Drug	N-methyl-DL-aspartic acid	PRKCG CACNA1I CACNA1H GRIK1 GRIK2 KARS1	2.65e-04	655	32	6	CID000004376
Drug	1xa5	GRIK1 GRIK2 KARS1	3.00e-04	93	32	3	CID000157684
Drug	tetradotoxin	PRKCG CACNA1I CACNA1H GRIK1 GRIK2	3.04e-04	428	32	5	CID000020382
Drug	glutamate	PRKCG CACNA1I CACNA1H GRIK1 GRIK2 KARS1 GAPDHS	3.13e-04	962	32	7	CID000000611
Drug	cyclopropanecarboxylic acid	CACNA1I CACNA1H	3.22e-04	19	32	2	CID000015655
Drug	nitrendipine	CACNA1I CACNA1H GRIK1	3.50e-04	98	32	3	CID000004507
Drug	AC1N8N2J	GRIK1 KARS1	3.58e-04	20	32	2	CID004346372
Drug	R1C	CACNA1I CACNA1H	3.58e-04	20	32	2	CID009961424
Drug	HCNs	CACNA1I CACNA1H	3.58e-04	20	32	2	CID006857665
Drug	loperamide	PRKCG CACNA1I CACNA1H	4.29e-04	105	32	3	CID000003954
Drug	pyraclofos	PRKCG CACNA1I CACNA1H	4.41e-04	106	32	3	CID000093460
Drug	gamma-aminobutyric acid	CACNA1I CACNA1H GRIK1 GRIK2 KIF1A	4.85e-04	474	32	5	CID000000119
Drug	hydroxamates	CACNA1I CACNA1H	5.63e-04	25	32	2	CID000033630
Drug	lamotrigine	CACNA1I CACNA1H GRIK1	5.74e-04	116	32	3	CID000003878
Drug	arabinosyladenine	PRKCG GRIK1 GRIK2 PDE4B KARS1 GAPDHS	5.93e-04	762	32	6	CID000000191
Drug	Pilocarpine	PRKCG GRIK1 GRIK2 ITGB1	6.56e-04	285	32	4	ctd:D010862
Drug	rufinamide	CACNA1I CACNA1H	7.59e-04	29	32	2	CID000129228
Drug	Linuron	CACNA1I GRIK1 GRIK2	7.64e-04	128	32	3	ctd:D008044
Drug	methyl cellosolve	PRKCG ITGB1 TLE4 NR5A2	7.65e-04	297	32	4	ctd:C005219
Drug	enzacamene	CACNA1I CACNA1H GRIK2	7.82e-04	129	32	3	ctd:C038939
Drug	AC1L1DXE	PRKCG CACNA1I CACNA1H GRIK1	7.84e-04	299	32	4	CID000002548
Drug	aniracetam	GRIK1 GRIK2 CDC45	7.99e-04	130	32	3	CID000002196
Drug	anacardic acid	CACNA1I CACNA1H	8.12e-04	30	32	2	CID000167551
Drug	oxcarbazepine	CACNA1I CACNA1H	8.12e-04	30	32	2	CID000034312
Drug	GYKI 53655	GRIK1 KARS1	8.12e-04	30	32	2	CID000126757
Drug	pyrachlostrobin	PRKCG HACD4 GRIK1 ITGB1 GLI2 SVEP1	8.22e-04	811	32	6	ctd:C513428
Drug	Barium permanganate	PRKCG CACNA1I CACNA1H	8.54e-04	133	32	3	CID000024587
Drug	S-nitroso-N-acetyl-D,L-penicillamine	GRIK1 GAPDHS RNF17	8.73e-04	134	32	3	CID000005231
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	PRKCG CACNA1I CACNA1H GRIK1	8.76e-04	308	32	4	CID000001915
Drug	SQ22536	PRKCG CACNA1I CACNA1H	8.92e-04	135	32	3	CID000005270
Drug	willardine	GRIK1 GRIK2	9.25e-04	32	32	2	CID000005123
Drug	halothane	PRKCG CACNA1I CACNA1H GRIK1	9.41e-04	314	32	4	CID000003562
Drug	octylmethoxycinnamate	CACNA1I CACNA1H GRIK2	9.70e-04	139	32	3	ctd:C118580
Disease	childhood absence epilepsy (is_implicated_in)	CACNA1H GRIK1	3.18e-05	8	32	2	DOID:1825 (is_implicated_in)
Disease	sciatic neuropathy (biomarker_via_orthology)	CACNA1I CACNA1H KARS1	1.69e-04	99	32	3	DOID:11446 (biomarker_via_orthology)
Disease	Autistic Disorder	CACNA1H GRIK2 PDE4B KIF1A	1.77e-04	261	32	4	C0004352
Disease	Manic Disorder	GRIK2 PDE4B	2.70e-03	71	32	2	C0024713
Disease	Alcoholic Intoxication, Chronic	GRIK1 PDE4B GLI2	3.02e-03	268	32	3	C0001973
Disease	Manic	GRIK2 PDE4B	3.25e-03	78	32	2	C0338831
Disease	Depression, Bipolar	GRIK2 PDE4B	3.33e-03	79	32	2	C0005587
Disease	Mechanical Allodynia	PRKCG CACNA1H	3.76e-03	84	32	2	C2936719
Disease	Hyperalgesia	PRKCG CACNA1H	3.76e-03	84	32	2	C0020429
Disease	Allodynia	PRKCG CACNA1H	3.76e-03	84	32	2	C0458247
Disease	Hyperalgesia, Secondary	PRKCG CACNA1H	3.76e-03	84	32	2	C0751212
Disease	Hyperalgesia, Primary	PRKCG CACNA1H	3.76e-03	84	32	2	C0751211
Disease	Hyperalgesia, Thermal	PRKCG CACNA1H	3.76e-03	84	32	2	C0751214
Disease	Tactile Allodynia	PRKCG CACNA1H	3.76e-03	84	32	2	C0751213

Protein segments in the cluster

Peptide	Gene	Start	Entry
YAMTSFHYTIMVTEA	CXCR6	261	O00574
MGMMTEYYHYFFTTL	GRIK1	246	P39086
TTMYALYITVHGYFL	ADGRG3	426	Q86Y34
NMYTMSHYYDYPSIA	ITGB1	306	P05556
YTLEHMHAFGMYNYL	NUDCD1	51	Q96RS6
GYYMYIEASHMVYGQ	MAMDC2	551	Q7Z304
MMLFIGMYFTYSHLY	HACD4	201	Q5VWC8
YTYVMEHLFRYMVGT	BNIPL	231	Q7Z465
YMMTLEDHYHSDVAY	PDE4B	391	Q07343
DHSMLYYYGQIHMYE	GLI2	1441	P10070
YFVMEYVTGGDLMYH	PRKCG	431	P05129
MYEMLYGETPFYAES	CDC42BPB	271	Q9Y5S2
YEYHGTSSAMVMFEL	CDC45	191	O75419
VTMNFGVHAIMYTYY	ELOVL3	171	Q9HB03
EIMYYVMDAHSFYNF	CACNA1I	361	Q9P0X4
TFYLSHREGYGTMYM	ANKMY1	51	Q9P2S6
GMMTEYYHYIFTTLD	GRIK2	246	Q13002
PEYMVYMFKYDSTHG	GAPDHS	111	O14556
VDIMYYVMDAHSFYN	CACNA1H	381	O95180
DNMSYSVEVSYMEIY	KIF1A	136	Q12756
PESIMGYSYMDSYQT	NR5A2	281	O00482
SYDDLSHLYPYFNMM	MEIOC	711	A2RUB1
STVAAMYYSYYMLPD	SFSWAP	361	Q12872
YMAYADYHDLMEITE	KARS1	341	Q15046
HSLYTTYKDYEIMFH	SIPA1L1	671	O43166
GTHSLYTMYQDYEIM	SIPA1L3	681	O60292
YTMYQDYEIMFHVST	SIPA1L3	686	O60292
DMITYSCYSGYMLEG	SVEP1	3436	Q4LDE5
MYYSAEHGYVDITME	ABTB2	721	Q8N961
DYHDENMYYSQSSMF	CNOT2	36	Q9NZN8
SIHLYFDGMSLSYFM	RNF17	1336	Q9BXT8
MAVAVFMEGFLFYYH	TMEM45B	121	Q96B21
HYVMYYEMSYGLNIE	TLE4	66	Q04727