Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

CDK9 NFAT5 CLOCK KMT2A LMX1A MAML2 EPC1 TAF4B THAP11

9.61e-061390239GO:0045944
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

CDK9 CLOCK GIGYF2 SYNE1

1.96e-04269234GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

CDK9 CLOCK GIGYF2 SYNE1

2.51e-04287234GO:0035770
GeneOntologyCellularComponentnuclear protein-containing complex

CDK9 CLOCK KMT2A SYNE1 TENT4B TAF4B THAP11

5.09e-041377237GO:0140513
Pubmed

First case of B ALL with KMT2A-MAML2 rearrangement: a case report.

KMT2A MAML2

4.18e-07223228535805
Pubmed

KMT2A-MAML2 rearrangement emerged and regressed during neuroblastoma therapy without leukemia after 12.8-year follow-up.

KMT2A MAML2

4.18e-07223234550633
Pubmed

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.

KMT2A EPC1

1.25e-06323224166297
Pubmed

The super elongation complex (SEC) family in transcriptional control.

CDK9 KMT2A

2.51e-06423222895430
Pubmed

An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.

CLOCK KMT2A

2.51e-06423223399917
Pubmed

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression.

CLOCK KMT2A

4.18e-06523221113167
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NFAT5 GIGYF2 ADCY2 SYNE1 SENP7

6.06e-0640723512693553
Pubmed

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.

CDK9 KMT2A

6.26e-06623221896721
Pubmed

SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation.

CDK9 KMT2A

8.77e-06723219818711
Pubmed

Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development.

LMX1A GIGYF2

1.17e-05823239117691
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

CDK9 ANKRD11 KMT2A GIGYF2 KCMF1 MAML2 EPC1

1.66e-05132723732694731
Pubmed

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.

CDK9 KMT2A

1.88e-051023220153263
Pubmed

CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis.

CDK9 KMT2A

1.88e-051023222094252
Pubmed

MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.

CDK9 KMT2A

3.79e-051423220854876
Pubmed

The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.

CDK9 KMT2A

6.36e-051823221030982
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

KMT2A EPC1 THAP11

9.36e-0513423325452129
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

CDK9 NFAT5 KMT2A GIGYF2 TENT4B

1.98e-0484723535850772
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CDK9 ANKRD11 KMT2A GIGYF2 CCDC88A

2.13e-0486123536931259
Pubmed

A census of human transcription factors: function, expression and evolution.

NFAT5 CLOCK KMT2A LMX1A THAP11

2.73e-0490823519274049
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

ANKRD11 KMT2A GIGYF2 KCMF1

2.94e-0449723436774506
Pubmed

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.

KMT2A EPC1

3.54e-044223235705031
Pubmed

Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.

CDK9 TAF4B

4.25e-04462328849451
Pubmed

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

CDK9 TAF4B

4.25e-044623225209997
Pubmed

Large-scale concatenation cDNA sequencing.

ADAM23 MBOAT2 ADCY2 KCMF1

4.87e-045682349110174
Pubmed

A "double adaptor" method for improved shotgun library construction.

ADAM23 MBOAT2 ADCY2 KCMF1

5.07e-045742348619474
Pubmed

New nomenclature for chromatin-modifying enzymes.

CLOCK KMT2A

6.53e-045723218022353
Cytoband16q22.1

NFAT5 THAP11

1.39e-0311023216q22.1
CytobandEnsembl 112 genes in cytogenetic band chr16q22

NFAT5 THAP11

3.78e-03183232chr16q22
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

ANKRD11 NFAT5 KMT2A SYNE1 KCMF1 CCDC88A SENP7 EPC1

2.46e-051492238M40023
CoexpressionGSE14350_TREG_VS_TEFF_UP

ANKRD11 CLOCK SYNE1 TENT4B

2.55e-05199234M3417
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NFAT5 ADAM23 IQUB MGAM2

2.56e-06190234078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAM23 ADCY2 LRFN5 SYNE1

3.02e-06198234c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAML2 TAF4B THAP11

7.01e-051572331e3a4a7193d95f09d71c2dfe704b8e626c6d9624
ToppCelldroplet-Marrow-nan-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIGYF2 CCDC88A MAML2

8.72e-051692335f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

KMT2A MBOAT2 SYNE1

1.00e-04177233e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-4|TCGA-Breast / Sample_Type by Project: Shred V9

KCMF1 MGAM2 TAF4B

1.02e-0417823344b5ba4e8788d3973749a1717e427647ac4c8579
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD11 KMT2A CCDC88A

1.12e-041842331154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ADAM23 SYNE1 SENP7

1.18e-04187233e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ANKRD11 NFAT5 KMT2A

1.20e-04188233ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM23 MBOAT2 IQUB

1.21e-041892333a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

NFAT5 SYNE1 MAML2

1.21e-04189233830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRFN5 SYNE1 MAML2

1.23e-04190233048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRFN5 SYNE1 MAML2

1.23e-041902331121eb607a984c59fbffe7220837fc178745aa55
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

ANKRD11 KMT2A CCDC88A

1.27e-041922339cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NFAT5 SYNE1 MAML2

1.29e-041932330f2167eef8203a5659c8c72e4e77646003d64797
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ANKRD11 NFAT5 MAML2

1.29e-04193233779276e775cb2492e8dd36436295a536084a6415
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADCY2 LRFN5 TAF4B

1.29e-04193233e5016959f24370579a8770787e96869f264cf7b3
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANKRD11 SYNE1 S100PBP

1.31e-041942336be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAM23 LRFN5 SYNE1

1.35e-04196233676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRFN5 SYNE1 MAML2

1.37e-04197233e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRFN5 SYNE1 MAML2

1.37e-0419723385a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANKRD11 KMT2A SYNE1

1.37e-0419723357ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRFN5 SYNE1 MAML2

1.37e-041972339b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAM23 LRFN5 SYNE1

1.39e-041982336d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAM23 LRFN5 SYNE1

1.39e-041982338ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

KMT2A CCDC88A EPC1

1.39e-04198233de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRFN5 SYNE1 MAML2

1.39e-04198233a860246bcea847249a78fd2e86ed8e04371060db
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAM23 LRFN5 SYNE1

1.39e-041982334ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ADAM23 LRFN5 SYNE1

1.44e-0420023348d801219bc771d6c7e151dc88ca4c179988de85
ToppCellCOVID-19|World / Disease, condition lineage and cell class

ANKRD11 KMT2A EPC1

1.44e-042002337dec470c379cd89f05a0f37c8628b21f136e52f0
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

ANKRD11 KMT2A SYNE1

2.47e-0549133GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
ComputationalNeighborhood of CASP2

KMT2A S100PBP

4.66e-0427132GCM_CASP2
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

ANKRD11 KMT2A

1.60e-0350132GAVISH_3CA_METAPROGRAM_B_CELLS_B_CELLS_1
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

NFAT5 SYNE1

1.60e-0350132GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
Diseaseanxiety disorder, stress-related disorder

GIGYF2 ADCY2

3.82e-0512232EFO_0006788, EFO_0010098
DiseaseNeurodevelopmental Disorders

ANKRD11 KMT2A GIGYF2

5.13e-0593233C1535926
Diseaseschizophrenia, intelligence, self reported educational attainment

KMT2A GIGYF2 MBOAT2 MAML2

1.38e-04346234EFO_0004337, EFO_0004784, MONDO_0005090
Diseaseunipolar depression, bipolar disorder

ADCY2 LRFN5 SYNE1

2.38e-04156233EFO_0003761, MONDO_0004985
Diseasewaist-hip ratio

NFAT5 CLOCK ADAM23 LMX1A IQUB EPC1

2.79e-041226236EFO_0004343
Diseasealcohol consumption measurement

ANKRD11 NFAT5 LMX1A MBOAT2 LRFN5 SENP7

2.99e-041242236EFO_0007878
Diseaseurate measurement, bone density

ANKRD11 SYNE1 MAML2 TAF4B

1.24e-03619234EFO_0003923, EFO_0004531
Diseasecongenital heart disease (implicated_via_orthology)

KMT2A ADCY2

1.32e-0369232DOID:1682 (implicated_via_orthology)
Diseasealcoholic liver disease

LRFN5 IQUB

1.86e-0382232EFO_0008573
Diseaseresponse to antineoplastic agent

NFAT5 ADCY2

2.69e-0399232GO_0097327
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

KMT2A SYNE1

2.80e-03101232EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Diseasebipolar I disorder

ADCY2 SYNE1

5.37e-03141232EFO_0009963
DiseaseBipolar Disorder

CLOCK ADCY2 SYNE1

5.85e-03477233C0005586
Diseasenasopharyngeal neoplasm

KMT2A EPC1

6.13e-03151232EFO_0004252
Diseasecreatinine measurement

ANKRD11 NFAT5 GIGYF2 ADCY2

6.82e-03995234EFO_0004518

Protein segments in the cluster

PeptideGeneStartEntry
IQQQQANSNSSTNTS

EPC1

606

Q9H2F5
STNTSQNLASNQQKS

EPC1

616

Q9H2F5
NTLQQNSSSNISYSN

ADAM23

91

O75077
RSTQQLQQQLNTSTQ

ANKRD11

2391

Q6UB99
TNVESQNTNRNNSTA

LRFN5

661

Q96NI6
TQTTNTSNSTNKSQH

TENT4B

501

Q8NDF8
NSFSTTNNVCNQNQE

MBOAT2

496

Q6ZWT7
QTNTTNASTSTNVAN

MGAM2

2146

Q2M2H8
NSTLNSQSTSLMNQN

CCDC88A

1111

Q3V6T2
QQDQQNTQRLSSAQT

LMX1A

261

Q8TE12
QSTSNSEQQAAFQQQ

NFAT5

1171

O94916
QSSISAQQQQQQQSS

MAML2

621

Q8IZL2
TANTTNTSFSASNNQ

ADCY2

711

Q08462
SVFQTNQSNNQQSNF

GIGYF2

1241

Q6Y7W6
NLQQTTNTTSTQMTN

IQUB

296

Q8NA54
IANTESSQQTLQNSQ

KCMF1

276

Q9P0J7
NNTSCQDSQSNNYQN

KMT2A

2576

Q03164
QQSTNQSRNPATTNQ

CDK9

351

P50750
QLSSSNNNFQQTVSD

S100PBP

211

Q96BU1
NSQSFIQQCVQQTSS

TAF4B

336

Q92750
QTVSQQSQAQQSQND

SENP7

881

Q9BQF6
SQQSNISSTQENLNS

SYNE1

2351

Q8NF91
QTLQSTSTQSQQNVL

CLOCK

626

O15516
FATQQQQSQTLSVTQ

CLOCK

741

O15516
QQQQQQQSSPSASTA

THAP11

126

Q96EK4