Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3T6 kinase activity	PRKCA PRKCB	1.76e-06	2	27	2	GO:0035403
GeneOntologyMolecularFunction	histone H3 kinase activity	PRKCA PRKCB	1.15e-04	12	27	2	GO:0140996
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKCA PRKCB	2.09e-04	16	27	2	GO:0004697
GeneOntologyMolecularFunction	histone modifying activity	PRKCA PRKCB USP51 RNF20	2.40e-04	229	27	4	GO:0140993
GeneOntologyMolecularFunction	histone kinase activity	PRKCA PRKCB	6.51e-04	28	27	2	GO:0035173
GeneOntologyMolecularFunction	histone binding	PRKCB USP51 RNF20	5.34e-03	265	27	3	GO:0042393
GeneOntologyCellularComponent	HULC complex	RNF40 RNF20	9.62e-06	4	27	2	GO:0033503
GeneOntologyCellularComponent	ubiquitin conjugating enzyme complex	RNF40 RNF20	5.75e-05	9	27	2	GO:0031371
GeneOntologyCellularComponent	calyx of Held	PRKCA PRKCB	9.85e-04	36	27	2	GO:0044305
GeneOntologyCellularComponent	presynaptic cytosol	PRKCA PRKCB	1.82e-03	49	27	2	GO:0099523
HumanPheno	Abnormal sclera morphology	DPAGT1 SALL1 GDF11 WNT5A	3.61e-05	141	8	4	HP:0000591
MousePheno	abnormal anal canal morphology	SALL1 GDF11 WNT5A	9.66e-06	27	22	3	MP:0009053
MousePheno	abnormal anus morphology	GDF11 WNT5A	1.82e-04	13	22	2	MP:0005034
MousePheno	abnormal digestive system development	PXN GDF11 WNT5A	2.12e-04	75	22	3	MP:0003119
MousePheno	anal atresia	SALL1 WNT5A	2.45e-04	15	22	2	MP:0003130
Domain	Protein_kinase_C_a/b/g	PRKCA PRKCB	5.59e-06	3	26	2	IPR014375
Domain	DAG/PE-bd	PRKCA PRKCB	3.85e-04	21	26	2	IPR020454
Domain	ZINC_FINGER_C2H2_2	ZNF131 SALL1 CHAMP1 ZNF280C ZBTB21 ZNF558	5.65e-04	775	26	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF131 SALL1 CHAMP1 ZNF280C ZBTB21 ZNF558	5.73e-04	777	26	6	PS00028
Domain	Znf_C2H2-like	ZNF131 SALL1 CHAMP1 ZNF280C ZBTB21 ZNF558	6.51e-04	796	26	6	IPR015880
Domain	Znf_C2H2	ZNF131 SALL1 CHAMP1 ZNF280C ZBTB21 ZNF558	6.91e-04	805	26	6	IPR007087
Domain	ZnF_C2H2	ZNF131 SALL1 CHAMP1 ZNF280C ZBTB21 ZNF558	7.04e-04	808	26	6	SM00355
Domain	Pkinase_C	PRKCA PRKCB	1.20e-03	37	26	2	IPR017892
Domain	Pkinase_C	PRKCA PRKCB	1.55e-03	42	26	2	PF00433
Domain	-	ZNF131 SALL1 CHAMP1 ZBTB21 ZNF558	2.18e-03	679	26	5	3.30.160.60
Domain	zf-C2H2	ZNF131 SALL1 CHAMP1 ZBTB21 ZNF558	2.38e-03	693	26	5	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF131 SALL1 CHAMP1 ZBTB21 ZNF558	2.40e-03	694	26	5	IPR013087
Domain	AGC-kinase_C	PRKCA PRKCB	2.74e-03	56	26	2	IPR000961
Domain	AGC_KINASE_CTER	PRKCA PRKCB	2.74e-03	56	26	2	PS51285
Domain	S_TK_X	PRKCA PRKCB	2.74e-03	56	26	2	SM00133
Domain	C1_1	PRKCA PRKCB	2.84e-03	57	26	2	PF00130
Domain	-	RNF32 RNF40 USP51 RNF20	3.24e-03	449	26	4	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF32 RNF40 USP51 RNF20	3.50e-03	459	26	4	IPR013083
Domain	ZF_DAG_PE_1	PRKCA PRKCB	3.56e-03	64	26	2	PS00479
Domain	ZF_DAG_PE_2	PRKCA PRKCB	3.56e-03	64	26	2	PS50081
Domain	zf-C3HC4	RNF32 RNF40 RNF20	3.57e-03	223	26	3	PF00097
Domain	C1	PRKCA PRKCB	3.67e-03	65	26	2	SM00109
Domain	PE/DAG-bd	PRKCA PRKCB	3.78e-03	66	26	2	IPR002219
Domain	LIM	PXN ABLIM1	4.13e-03	69	26	2	PF00412
Domain	-	PXN ABLIM1	4.25e-03	70	26	2	2.10.110.10
Domain	LIM_DOMAIN_2	PXN ABLIM1	4.37e-03	71	26	2	PS50023
Domain	Znf_LIM	PXN ABLIM1	4.37e-03	71	26	2	IPR001781
Domain	LIM_DOMAIN_1	PXN ABLIM1	4.37e-03	71	26	2	PS00478
Domain	LIM	PXN ABLIM1	4.37e-03	71	26	2	SM00132
Domain	ZF_RING_1	RNF32 RNF40 RNF20	7.47e-03	291	26	3	PS00518
Domain	ZF_RING_2	RNF32 RNF40 RNF20	7.97e-03	298	26	3	PS50089
Domain	RING	RNF32 RNF40 RNF20	8.49e-03	305	26	3	SM00184
Domain	Znf_RING	RNF32 RNF40 RNF20	1.02e-02	326	26	3	IPR001841
Domain	C2	PRKCA PRKCB	1.42e-02	131	26	2	PF00168
Domain	BTB	ZNF131 ZBTB21	1.42e-02	131	26	2	PF00651
Domain	C2	PRKCA PRKCB	1.55e-02	137	26	2	SM00239
Domain	C2	PRKCA PRKCB	1.66e-02	142	26	2	PS50004
Domain	-	PRKCA PRKCB	1.79e-02	148	26	2	2.60.40.150
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US27_TO_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	PXN PRKCA PRKCB	1.36e-07	8	20	3	M47555
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	PRKCA PRKCB WNT5A	1.10e-06	15	20	3	M27413
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	PXN PRKCA PRKCB	1.07e-05	31	20	3	M47554
Pathway	WP_WNT_SIGNALING_PATHWAY	PRKCA PRKCB SALL1 WNT5A	1.54e-05	110	20	4	MM15977
Pathway	BIOCARTA_ION_PATHWAY	PRKCA PRKCB	1.91e-05	5	20	2	MM1574
Pathway	BIOCARTA_PLCD_PATHWAY	PRKCA PRKCB	1.91e-05	5	20	2	MM1587
Pathway	BIOCARTA_ION_PATHWAY	PRKCA PRKCB	1.91e-05	5	20	2	M22059
Pathway	BIOCARTA_PLCD_PATHWAY	PRKCA PRKCB	1.91e-05	5	20	2	M22080
Pathway	REACTOME_DISINHIBITION_OF_SNARE_FORMATION	PRKCA PRKCB	1.91e-05	5	20	2	M26920
Pathway	BIOCARTA_ERBB4_PATHWAY	PRKCA PRKCB	4.00e-05	7	20	2	MM1563
Pathway	BIOCARTA_PKC_PATHWAY	PRKCA PRKCB	4.00e-05	7	20	2	MM1572
Pathway	BIOCARTA_ERBB4_PATHWAY	PRKCA PRKCB	4.00e-05	7	20	2	M22043
Pathway	BIOCARTA_PKC_PATHWAY	PRKCA PRKCB	4.00e-05	7	20	2	M22057
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_PLCG_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	5.33e-05	8	20	2	M47479
Pathway	BIOCARTA_PLC_PATHWAY	PRKCA PRKCB	6.84e-05	9	20	2	M22029
Pathway	BIOCARTA_PLC_PATHWAY	PRKCA PRKCB	6.84e-05	9	20	2	MM1551
Pathway	WP_WNT_SIGNALING	PRKCA PRKCB WNT5A	8.34e-05	61	20	3	MM15893
Pathway	BIOCARTA_SRCRPTP_PATHWAY	PRKCA PRKCB	8.55e-05	10	20	2	MM1341
Pathway	BIOCARTA_AGPCR_PATHWAY	PRKCA PRKCB	8.55e-05	10	20	2	MM1352
Pathway	KEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	8.55e-05	10	20	2	M47644
Pathway	WP_ONCOSTATIN_M_SIGNALING	PXN PRKCA PRKCB	1.01e-04	65	20	3	M39562
Pathway	BIOCARTA_CBL_PATHWAY	PRKCA PRKCB	1.04e-04	11	20	2	MM1360
Pathway	BIOCARTA_AGPCR_PATHWAY	PRKCA PRKCB	1.04e-04	11	20	2	M19829
Pathway	KEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	1.04e-04	11	20	2	M47637
Pathway	BIOCARTA_SRCRPTP_PATHWAY	PRKCA PRKCB	1.04e-04	11	20	2	M10994
Pathway	BIOCARTA_MYOSIN_PATHWAY	PRKCA PRKCB	1.04e-04	11	20	2	M7014
Pathway	PID_VEGFR1_2_PATHWAY	PXN PRKCA PRKCB	1.21e-04	69	20	3	M237
Pathway	BIOCARTA_CBL_PATHWAY	PRKCA PRKCB	1.25e-04	12	20	2	M16973
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	1.25e-04	12	20	2	M47597
Pathway	KEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	1.25e-04	12	20	2	M47649
Pathway	KEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY	PRKCA PRKCB	1.25e-04	12	20	2	M47628
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	PRKCA PRKCB	1.48e-04	13	20	2	M47656
Pathway	KEGG_VEGF_SIGNALING_PATHWAY	PXN PRKCA PRKCB	1.61e-04	76	20	3	M1749
Pathway	PID_TCR_RAS_PATHWAY	PRKCA PRKCB	1.72e-04	14	20	2	M134
Pathway	REACTOME_WNT5A_DEPENDENT_INTERNALIZATION_OF_FZD4	PRKCB WNT5A	1.72e-04	14	20	2	MM15161
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	1.72e-04	14	20	2	M47383
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	1.72e-04	14	20	2	M47384
Pathway	BIOCARTA_TRKA_PATHWAY	PRKCA PRKCB	1.72e-04	14	20	2	M9134
Pathway	BIOCARTA_CDMAC_PATHWAY	PRKCA PRKCB	1.99e-04	15	20	2	MM1358
Pathway	BIOCARTA_TRKA_PATHWAY	PRKCA PRKCB	1.99e-04	15	20	2	MM1523
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY	PRKCA PRKCB	1.99e-04	15	20	2	M47382
Pathway	REACTOME_DEPOLYMERIZATION_OF_THE_NUCLEAR_LAMINA	PRKCA PRKCB	1.99e-04	15	20	2	M27360
Pathway	BIOCARTA_MEF2D_PATHWAY	PRKCA PRKCB	2.27e-04	16	20	2	MM1483
Pathway	BIOCARTA_SPPA_PATHWAY	PRKCA PRKCB	2.27e-04	16	20	2	M8731
Pathway	BIOCARTA_CDMAC_PATHWAY	PRKCA PRKCB	2.27e-04	16	20	2	M4388
Pathway	BIOCARTA_CCR5_PATHWAY	PRKCA PRKCB	2.57e-04	17	20	2	M2349
Pathway	REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS	PRKCA PRKCB	2.57e-04	17	20	2	M5488
Pathway	REACTOME_PCP_CE_PATHWAY	PRKCA PRKCB WNT5A	2.83e-04	92	20	3	M27322
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PRKCA PRKCB	2.89e-04	18	20	2	M3430
Pathway	BIOCARTA_CHEMICAL_PATHWAY	PRKCA PRKCB	2.89e-04	18	20	2	MM1350
Pathway	BIOCARTA_CARDIACEGF_PATHWAY	PRKCA PRKCB	2.89e-04	18	20	2	MM1479
Pathway	BIOCARTA_CARDIACEGF_PATHWAY	PRKCA PRKCB	2.89e-04	18	20	2	M7552
Pathway	BIOCARTA_MEF2D_PATHWAY	PRKCA PRKCB	2.89e-04	18	20	2	M5290
Pathway	BIOCARTA_CHEMICAL_PATHWAY	PRKCA PRKCB	2.89e-04	18	20	2	M3873
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	PRKCA PRKCB	2.89e-04	18	20	2	MM1385
Pathway	BIOCARTA_CCR5_PATHWAY	PRKCA PRKCB	3.22e-04	19	20	2	MM1453
Pathway	BIOCARTA_CCR3_PATHWAY	PRKCA PRKCB	3.22e-04	19	20	2	MM1361
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	PRKCA PRKCB	3.22e-04	19	20	2	M27423
Pathway	KEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY	PRKCA PRKCB	3.22e-04	19	20	2	M47596
Pathway	BIOCARTA_PAR1_PATHWAY	PRKCA PRKCB	3.22e-04	19	20	2	MM1514
Pathway	BIOCARTA_PAR1_PATHWAY	PRKCA PRKCB	3.22e-04	19	20	2	M3494
Pathway	BIOCARTA_CXCR4_PATHWAY	PRKCA PRKCB	3.22e-04	19	20	2	MM1375
Pathway	BIOCARTA_CXCR4_PATHWAY	PRKCA PRKCB	3.22e-04	19	20	2	M882
Pathway	BIOCARTA_CCR3_PATHWAY	PRKCA PRKCB	3.22e-04	19	20	2	M9152
Pathway	BIOCARTA_NOS1_PATHWAY	PRKCA PRKCB	3.58e-04	20	20	2	MM1445
Pathway	BIOCARTA_EDG1_PATHWAY	PRKCA PRKCB	3.58e-04	20	20	2	MM1456
Pathway	BIOCARTA_CREB_PATHWAY	PRKCA PRKCB	3.58e-04	20	20	2	MM1520
Pathway	BIOCARTA_ARENRF2_PATHWAY	PRKCA PRKCB	3.58e-04	20	20	2	M14339
Pathway	WP_IL3_SIGNALING_PATHWAY	PXN PRKCA PRKCB	3.62e-04	100	20	3	MM15879
Pathway	KEGG_MELANOGENESIS	PRKCA PRKCB WNT5A	3.72e-04	101	20	3	M7761
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	PRKCA PRKCB WNT5A	3.72e-04	101	20	3	MM15829
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	PRKCA PRKCB WNT5A	3.72e-04	101	20	3	M39387
Pathway	KEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	3.95e-04	21	20	2	M47638
Pathway	BIOCARTA_NOS1_PATHWAY	PRKCA PRKCB	3.95e-04	21	20	2	M11650
Pathway	REACTOME_SIGNALING_BY_VEGF	PXN PRKCA PRKCB	4.29e-04	106	20	3	M27077
Pathway	BIOCARTA_ARENRF2_PATHWAY	PRKCA PRKCB	4.34e-04	22	20	2	MM1449
Pathway	BIOCARTA_EDG1_PATHWAY	PRKCA PRKCB	4.34e-04	22	20	2	M10579
Pathway	BIOCARTA_CREB_PATHWAY	PRKCA PRKCB	4.34e-04	22	20	2	M9070
Pathway	BIOCARTA_EIF4_PATHWAY	PRKCA PRKCB	4.75e-04	23	20	2	MM1470
Pathway	WP_WNT_SIGNALING_WP428	PRKCA PRKCB WNT5A	5.18e-04	113	20	3	M39669
Pathway	BIOCARTA_EIF4_PATHWAY	PRKCA PRKCB	5.18e-04	24	20	2	M4791
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	PRKCA PRKCB	5.18e-04	24	20	2	M27553
Pathway	BIOCARTA_TPO_PATHWAY	PRKCA PRKCB	5.18e-04	24	20	2	M11520
Pathway	KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	PXN PRKCA PRKCB	5.59e-04	116	20	3	M2164
Pathway	BIOCARTA_TPO_PATHWAY	PRKCA PRKCB	5.63e-04	25	20	2	MM1519
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	PRKCA PRKCB WNT5A	5.87e-04	118	20	3	M39852
Pathway	BIOCARTA_AT1R_PATHWAY	PRKCA PRKCB	6.09e-04	26	20	2	MM1346
Pathway	PID_VEGFR1_PATHWAY	PRKCA PRKCB	6.09e-04	26	20	2	M226
Pathway	BIOCARTA_PYK2_PATHWAY	PRKCA PRKCB	6.09e-04	26	20	2	MM1431
Pathway	KEGG_MEDICUS_REFERENCE_CCR5_GNB_G_PLCB_G_PKC_SIGNALING_PATHWAY	PRKCA PRKCB	6.09e-04	26	20	2	M47557
Pathway	BIOCARTA_AT1R_PATHWAY	PRKCA PRKCB	6.57e-04	27	20	2	M14899
Pathway	BIOCARTA_PYK2_PATHWAY	PRKCA PRKCB	6.57e-04	27	20	2	M7739
Pathway	BIOCARTA_EGF_PATHWAY	PRKCA PRKCB	6.57e-04	27	20	2	M1909
Pathway	BIOCARTA_VEGF_PATHWAY	PRKCA PRKCB	6.57e-04	27	20	2	M12975
Pathway	BIOCARTA_GH_PATHWAY	PRKCA PRKCB	6.57e-04	27	20	2	M9043
Pathway	WP_SPHINGOLIPID_METABOLISM_IN_SENESCENCE	PRKCA PRKCB	7.07e-04	28	20	2	M42536
Pathway	PID_IL8_CXCR1_PATHWAY	PRKCA PRKCB	7.07e-04	28	20	2	M252
Pathway	BIOCARTA_EGF_PATHWAY	PRKCA PRKCB	7.07e-04	28	20	2	MM1386
Pathway	BIOCARTA_PDGF_PATHWAY	PRKCA PRKCB	7.07e-04	28	20	2	M2529
Pathway	BIOCARTA_PDGF_PATHWAY	PRKCA PRKCB	7.59e-04	29	20	2	MM1452
Pubmed	Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.	PRKCA PRKCB WNT5A	1.46e-08	7	27	3	12958364
Pubmed	Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose.	PRKCA PRKCB	5.80e-07	2	27	2	26660275
Pubmed	Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes.	PRKCA PRKCB	5.80e-07	2	27	2	25616575
Pubmed	PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.	PRKCA PRKCB	5.80e-07	2	27	2	23439007
Pubmed	E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair.	RNF40 RNF20	5.80e-07	2	27	2	30692271
Pubmed	Insulin inhibits phagocytosis in normal human neutrophils via PKCalpha/beta-dependent priming of F-actin assembly.	PRKCA PRKCB	5.80e-07	2	27	2	16673150
Pubmed	Heterogeneity of cellular proliferation within transitional cell carcinoma: correlation of protein kinase C alpha/betaI expression and activity.	PRKCA PRKCB	5.80e-07	2	27	2	16517978
Pubmed	Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.	RNF40 RNF20	5.80e-07	2	27	2	22354749
Pubmed	Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2.	PRKCA PRKCB	5.80e-07	2	27	2	25693686
Pubmed	RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease.	RNF40 RNF20	5.80e-07	2	27	2	34088983
Pubmed	All-trans retinoic acid and protein kinase C α/β1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression.	PRKCA PRKCB	5.80e-07	2	27	2	33723318
Pubmed	Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKC.	PRKCA PRKCB	5.80e-07	2	27	2	22993418
Pubmed	Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held.	PRKCA PRKCB	5.80e-07	2	27	2	21658591
Pubmed	Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling.	PRKCA PRKCB	5.80e-07	2	27	2	24151077
Pubmed	The essentiality of PKCalpha and PKCbetaI translocation for CD14+monocyte differentiation towards macrophages and dendritic cells, respectively.	PRKCA PRKCB	5.80e-07	2	27	2	17455194
Pubmed	Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.	PRKCA PRKCB	5.80e-07	2	27	2	27657532
Pubmed	Wnt5a promotes vasculogenic mimicry and epithelial-mesenchymal transition via protein kinase Cα in epithelial ovarian cancer.	PRKCA WNT5A	5.80e-07	2	27	2	24898696
Pubmed	Epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells induced by urinary proteins requires the activation of PKC-α and βI isozymes.	PRKCA PRKCB	5.80e-07	2	27	2	21323641
Pubmed	Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held.	PRKCA PRKCB	5.80e-07	2	27	2	23035091
Pubmed	RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo.	RNF40 RNF20	5.80e-07	2	27	2	37422774
Pubmed	Distinct functions of protein kinase Calpha and protein kinase Cbeta during retinoic acid-induced differentiation of F9 cells.	PRKCA PRKCB	5.80e-07	2	27	2	9486851
Pubmed	Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.	RNF40 RNF20	5.80e-07	2	27	2	20738173
Pubmed	Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.	PRKCA PRKCB	5.80e-07	2	27	2	29307535
Pubmed	Genes encoding catalytic subunits of protein kinase A and risk of spina bifida.	PRKCA PRKCB	5.80e-07	2	27	2	16080189
Pubmed	Receptor-specific regulation of atrial GIRK channel activity by different Ca2+-dependent PKC isoforms.	PRKCA PRKCB	5.80e-07	2	27	2	31525436
Pubmed	Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways.	PRKCA PRKCB	5.80e-07	2	27	2	16430878
Pubmed	Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells.	PRKCA PRKCB	5.80e-07	2	27	2	28415683
Pubmed	Inhibition of the calcium release-activated calcium (CRAC) current in Jurkat T cells by the HIV-1 envelope protein gp160.	PRKCA PRKCB	5.80e-07	2	27	2	11744714
Pubmed	The roles of Wnt5a, JNK and paxillin in the occurrence of metastasis of pancreatic adenocarcinoma.	PXN WNT5A	5.80e-07	2	27	2	24395444
Pubmed	cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes.	PRKCA PRKCB	5.80e-07	2	27	2	14527960
Pubmed	Unravelling the different functions of protein kinase C isoforms in platelets.	PRKCA PRKCB	5.80e-07	2	27	2	21596041
Pubmed	Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.	RNF40 RNF20	5.80e-07	2	27	2	34290256
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PXN ZNF131 RNF40 SALL1 CHAMP1 ZBTB21	6.95e-07	418	27	6	34709266
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	PXN ZNF131 ABLIM1 SUGP2 CHAMP1 ZNF280C	1.41e-06	472	27	6	38943005
Pubmed	Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.	PRKCA PRKCB	1.74e-06	3	27	2	1714454
Pubmed	Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.	PRKCA PRKCB	1.74e-06	3	27	2	32367578
Pubmed	Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy.	PRKCA PRKCB	1.74e-06	3	27	2	23434935
Pubmed	Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.	PRKCA PRKCB	1.74e-06	3	27	2	1324914
Pubmed	The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination.	RNF40 RNF20	1.74e-06	3	27	2	22021426
Pubmed	RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.	RNF40 RNF20	1.74e-06	3	27	2	21827756
Pubmed	A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells.	PRKCA PRKCB	1.74e-06	3	27	2	24316392
Pubmed	Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.	PRKCA PRKCB	1.74e-06	3	27	2	9814702
Pubmed	Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation.	PRKCA PRKCB	1.74e-06	3	27	2	19895572
Pubmed	Spatiotemporal regulation of PKC via interactions with AKAP7 isoforms.	PRKCA PRKCB	1.74e-06	3	27	2	22670899
Pubmed	Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.	PRKCA PRKCB	1.74e-06	3	27	2	19556521
Pubmed	Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans.	PRKCA PRKCB	1.74e-06	3	27	2	16775601
Pubmed	Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation.	PRKCA PRKCB	1.74e-06	3	27	2	17936705
Pubmed	The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.	RNF40 RNF20	1.74e-06	3	27	2	27798111
Pubmed	Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.	RNF40 RNF20	1.74e-06	3	27	2	22155569
Pubmed	Expression of protein kinase C isoenzymes alpha, betaI, and delta in subtypes of intercalated cells of mouse kidney.	PRKCA PRKCB	1.74e-06	3	27	2	16735462
Pubmed	Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.	PRKCA PRKCB	1.74e-06	3	27	2	30904392
Pubmed	Specific protein kinase C isoforms α and βI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption.	PRKCA PRKCB	1.74e-06	3	27	2	23028752
Pubmed	PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport.	PRKCA PRKCB	1.74e-06	3	27	2	23977398
Pubmed	Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice.	PRKCA PRKCB	1.74e-06	3	27	2	7760054
Pubmed	Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling.	PRKCA PRKCB	1.74e-06	3	27	2	20237998
Pubmed	S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells.	PRKCA PRKCB	1.74e-06	3	27	2	18162471
Pubmed	Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts.	PRKCA PRKCB	1.74e-06	3	27	2	19066285
Pubmed	The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.	PRKCA PRKCB	1.74e-06	3	27	2	12080070
Pubmed	Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfates.	PRKCA PRKCB	1.74e-06	3	27	2	18313852
Pubmed	Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.	PRKCA PRKCB	1.74e-06	3	27	2	22819675
Pubmed	Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.	PRKCA PRKCB	1.74e-06	3	27	2	3755548
Pubmed	Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse.	PRKCA PRKCB	1.74e-06	3	27	2	27307229
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	PXN ZNF131 ABLIM1 SALL1 ZNF280C PARP12 ZBTB21	2.11e-06	808	27	7	20412781
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZNF131 CHAMP1 ZNF280C ZBTB21	2.62e-06	125	27	4	32891193
Pubmed	Nanomolar amyloid beta protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells.	PRKCA PRKCB	3.48e-06	4	27	2	11930178
Pubmed	Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.	PRKCA PRKCB	3.48e-06	4	27	2	9244383
Pubmed	Phosphorylation of p300 at serine 89 by protein kinase C.	PRKCA PRKCB	3.48e-06	4	27	2	11020388
Pubmed	STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.	PRKCA PRKCB	3.48e-06	4	27	2	24493668
Pubmed	Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes.	PRKCA PRKCB	3.48e-06	4	27	2	26404773
Pubmed	Ring finger 20/ring finger 40/WW domain-containing adaptor with coiled-coil complex interacts with p53 to regulate gene transcription in DNA damage response.	RNF40 RNF20	3.48e-06	4	27	2	33868474
Pubmed	Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets.	PRKCA PRKCB	3.48e-06	4	27	2	10856305
Pubmed	Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase.	PRKCA PRKCB	3.48e-06	4	27	2	19681907
Pubmed	Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization.	PRKCA PRKCB	3.48e-06	4	27	2	15367584
Pubmed	Effects of the antiandrogen flutamide on the expression of protein kinase C isoenzymes in LNCaP and PC3 human prostate cancer cells.	PRKCA PRKCB	3.48e-06	4	27	2	15499829
Pubmed	Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B mono-ubiquitination.	RNF40 RNF20	3.48e-06	4	27	2	28453857
Pubmed	Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.	PRKCA PRKCB	3.48e-06	4	27	2	10871288
Pubmed	PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.	PRKCA PRKCB	3.48e-06	4	27	2	8557118
Pubmed	Physiological regulation of Munc18/nSec1 phosphorylation on serine-313.	PRKCA PRKCB	3.48e-06	4	27	2	12950453
Pubmed	Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin.	PRKCA PRKCB	3.48e-06	4	27	2	8631738
Pubmed	TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.	RNF40 RNF20	3.48e-06	4	27	2	26781088
Pubmed	Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes.	PRKCA PRKCB	3.48e-06	4	27	2	22318721
Pubmed	Triggering Ras signalling by intracellular Francisella tularensis through recruitment of PKCα and βI to the SOS2/GrB2 complex is essential for bacterial proliferation in the cytosol.	PRKCA PRKCB	3.48e-06	4	27	2	20618341
Pubmed	Cell cycle phase-specific phosphorylation of human topoisomerase II alpha. Evidence of a role for protein kinase C.	PRKCA PRKCB	3.48e-06	4	27	2	7499337
Pubmed	Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.	PRKCA PRKCB	3.48e-06	4	27	2	9694886
Pubmed	Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.	RNF40 RNF20	3.48e-06	4	27	2	21362549
Pubmed	Presynaptic Short-Term Plasticity Persists in the Absence of PKC Phosphorylation of Munc18-1.	PRKCA PRKCB	3.48e-06	4	27	2	34290081
Pubmed	Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.	RNF40 RNF20	3.48e-06	4	27	2	38517892
Pubmed	Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.	PRKCA PRKCB	3.48e-06	4	27	2	8662663
Pubmed	Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition.	PRKCA PRKCB	3.48e-06	4	27	2	24401212
Pubmed	Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase Calpha.	PRKCA WNT5A	3.48e-06	4	27	2	19096028
Pubmed	Cloning of a mouse protein kinase A catalytic subunit pseudogene and chromosomal mapping of C subunit isoforms.	PRKCA PRKCB	3.48e-06	4	27	2	7873880
Pubmed	Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.	RNF40 RNF20	3.48e-06	4	27	2	32672815
Pubmed	Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.	PRKCA PRKCB	3.48e-06	4	27	2	11063746
Pubmed	Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain.	PRKCA PRKCB	3.48e-06	4	27	2	8080473
Pubmed	SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.	RNF40 RNF20	3.48e-06	4	27	2	24441044
Pubmed	Regulation of ARNO nucleotide exchange by a PH domain electrostatic switch.	PRKCA PRKCB	3.48e-06	4	27	2	10531036
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZNF131 ABLIM1 SUGP2 CHAMP1 ZNF280C PARP12 ZBTB21	5.47e-06	934	27	7	33916271
Pubmed	A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.	PRKCA PRKCB	5.80e-06	5	27	2	7513693
Pubmed	Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst.	PRKCA PRKCB	5.80e-06	5	27	2	11145703
Pubmed	Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.	PRKCA PRKCB	5.80e-06	5	27	2	12569090
Interaction	NRGN interactions	PRKCA ZNF131 PRKCB	1.82e-06	19	26	3	int:NRGN
Interaction	TERF2IP interactions	ZNF131 RNF40 SUGP2 CHAMP1 ZNF280C ZBTB21 RNF20	4.66e-06	552	26	7	int:TERF2IP
Interaction	DSN1 interactions	RNF40 SALL1 CHAMP1 RNF20	6.95e-06	97	26	4	int:DSN1
Interaction	FBXO7 interactions	PRKCA PRKCB RNF40 CMTR2 KMO RNF20	9.23e-05	598	26	6	int:FBXO7
Interaction	PPIA interactions	PXN ZNF131 ABLIM1 SUGP2 CHAMP1 ZNF280C RNF20	9.92e-05	888	26	7	int:PPIA
Interaction	TIAM1 interactions	PRKCA PRKCB ZBTB21 ZNF558	1.30e-04	205	26	4	int:TIAM1
Interaction	MAGEA9 interactions	RNF40 SALL1 HERC2 SUGP2	1.38e-04	208	26	4	int:MAGEA9
Interaction	H2BC3 interactions	PRKCB RNF40 USP51 CHAMP1 RNF20	1.50e-04	406	26	5	int:H2BC3
Interaction	OLFML3 interactions	DPAGT1 KMO	1.66e-04	15	26	2	int:OLFML3
Interaction	CDK8 interactions	ZNF131 HERC2 SUGP2 RNF20	1.77e-04	222	26	4	int:CDK8
Interaction	NAA40 interactions	ZNF131 ABLIM1 SUGP2 CHAMP1 ZNF280C PARP12 ZBTB21	1.81e-04	978	26	7	int:NAA40
Interaction	AR interactions	PXN RNF40 SUGP2 CHAMP1 PARP12 ZBTB21 RNF20	1.98e-04	992	26	7	int:AR
Interaction	SAMD3 interactions	HERC2 SUGP2	2.15e-04	17	26	2	int:SAMD3
Interaction	CHAT interactions	PRKCA PRKCB	2.42e-04	18	26	2	int:CHAT
Interaction	RRAD interactions	PRKCA PRKCB	3.00e-04	20	26	2	int:RRAD
Interaction	IL36A interactions	RNF40 RNF20	3.31e-04	21	26	2	int:IL36A
Interaction	G0S2 interactions	RNF40 RNF20	3.31e-04	21	26	2	int:G0S2
Interaction	KIF11 interactions	PRKCA RNF40 HERC2 RNF20	3.58e-04	267	26	4	int:KIF11
Interaction	CASR interactions	PRKCA PRKCB	3.64e-04	22	26	2	int:CASR
Interaction	GSTA1 interactions	USP51 ZBTB21	3.64e-04	22	26	2	int:GSTA1
Interaction	ZMYM2 interactions	ZNF131 CHAMP1 ZNF280C ZBTB21	3.79e-04	271	26	4	int:ZMYM2
GeneFamily	C2 domain containing protein kinases	PRKCA PRKCB	5.75e-05	10	21	2	835
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF131 SALL1 CHAMP1 ZBTB21 ZNF558	1.17e-03	718	21	5	28
GeneFamily	LIM domain containing	PXN ABLIM1	2.11e-03	59	21	2	1218
GeneFamily	Ring finger proteins	RNF32 RNF40 RNF20	3.78e-03	275	21	3	58
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZNF131 ZBTB21	1.04e-02	134	21	2	861
Coexpression	GSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP	PRKCA PRKCB HERC2 USP51	4.06e-05	197	26	4	M7403
Coexpression	GSE20366_EX_VIVO_VS_DEC205_CONVERSION_NAIVE_CD4_TCELL_DN	PRKCA GPR176 WNT5A ZBTB21	4.23e-05	199	26	4	M4328
Coexpression	GSE18893_CTRL_VS_TNF_TREATED_TCONV_2H_DN	DPAGT1 EXTL3 HERC2 ZNF280C	4.31e-05	200	26	4	M7302
Coexpression	GSE17721_CTRL_VS_GARDIQUIMOD_0.5H_BMDC_UP	PXN GDF11 PARP12 RNF20	4.31e-05	200	26	4	M3774
CoexpressionAtlas	EB blastocyst_vs_EB BM CD34+-Confounder_removed-fold2.0_adjp0.05	SALL1 ZNF558	3.02e-05	7	26	2	PCBC_ratio_EB blastocyst_vs_EB BM CD34+_cfr-2X-p05
ToppCell	droplet-Bladder-nan-3m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPAGT1 PRKCB RNF40	5.04e-05	119	27	3	018162114bc22a9780fded5887f1f78211851700
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SALL1 GPR176 WNT5A	8.88e-05	144	27	3	0322fef818a963be00535d5f141f028d43de5c6a
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SALL1 GPR176 WNT5A	8.88e-05	144	27	3	04f9054895be2275eecda687a6eeb02fa5ec69b9
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SALL1 GPR176 WNT5A	9.06e-05	145	27	3	590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SALL1 GPR176 WNT5A	1.13e-04	156	27	3	896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SALL1 GPR176 WNT5A	1.24e-04	161	27	3	be77e99faf653480c166305df3a4e93db76f0dcb
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	PRKCA PRKCB EXTL3	1.43e-04	169	27	3	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	PRKCA PRKCB EXTL3	1.45e-04	170	27	3	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SALL1 WNT5A PARP12	1.50e-04	172	27	3	8b396d1e9173da104d467e42286379fe07cee257
ToppCell	BAL-Mild-cDC_3\|Mild / Compartment, Disease Groups and Clusters	PRKCA CHAMP1 WNT5A	1.61e-04	176	27	3	f9b0c3ced391e7ebe6b242d3f12ba14741f88d22
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PRKCB ZNF280C ZNF558	1.63e-04	177	27	3	eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM1 USP51 CHAMP1	1.63e-04	177	27	3	b8de0fc92691a6d6759c743195b11edd2d63f265
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PXN PRKCB GDF11	1.69e-04	179	27	3	063c05753ef1b4a18bc1ebbcae62c8cd25d11070
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PXN PRKCB GDF11	1.69e-04	179	27	3	42f3c040f504a91cc69292d39d22b5715c12526f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SALL1 WNT5A PARP12	1.69e-04	179	27	3	5bf191bdc0c32bce83ab5c38f0616e209e420e55
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRKCB ABLIM1 KMO	1.74e-04	181	27	3	477c572c5c1efceee49732cc9e8b1dad68a7e6e5
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRKCB ABLIM1 KMO	1.74e-04	181	27	3	909280b44085d8e96fcd3cbcba6bff94badd41e8
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB ABLIM1 KMO	1.74e-04	181	27	3	ce0e39114bf3bcbcce0fd4c0d70bedadd0853e1d
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB ABLIM1 KMO	1.86e-04	185	27	3	eb338fcda0b237c2e0b9b4b0daf51febbfe1d79c
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB ABLIM1 KMO	1.86e-04	185	27	3	c31bb53852caf36964b83b28bcaee07b679da779
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|bone_marrow / Manually curated celltypes from each tissue	PRKCA ABLIM1 USP51	1.89e-04	186	27	3	5108d9b7a081876ca34594b110d58df56063f542
ToppCell	343B-Lymphocytic-ILC-ILC-1\|343B / Donor, Lineage, Cell class and subclass (all cells)	EXTL3 PARP12 ZBTB21	1.95e-04	188	27	3	8f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCA PRKCB WNT5A	1.98e-04	189	27	3	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCA PRKCB WNT5A	2.01e-04	190	27	3	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCA PRKCB WNT5A	2.01e-04	190	27	3	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCA PRKCB WNT5A	2.04e-04	191	27	3	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	facs-Marrow-B-cells\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB ABLIM1 KMO	2.04e-04	191	27	3	f84cd55e6fb112d271d35db11ad7648e03186e46
ToppCell	facs-Marrow-B-cells-18m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB ABLIM1 KMO	2.04e-04	191	27	3	e53290441a25d6245a96540445186db22026801c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCA PRKCB WNT5A	2.04e-04	191	27	3	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCA PRKCB WNT5A	2.04e-04	191	27	3	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	Healthy_Control-Lymphoid-T-CCR7+_T\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PXN PRKCB ABLIM1	2.08e-04	192	27	3	5b197f65a87c315e4f50c77a7fdec3b342a863ad
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EXTL3 PARP12 ZBTB21	2.08e-04	192	27	3	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	facs-Marrow-B-cells-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB ABLIM1 KMO	2.11e-04	193	27	3	24c34c6635eb7fc2878282803c421b64320e77d8
ToppCell	Control-Myeloid-MoAM4\|Myeloid / Condition, Lineage and Cell class	PXN PRKCA PRKCB	2.14e-04	194	27	3	7ab808dd1876b0eec2831caa16d04fd859b1dc50
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCA PRKCB WNT5A	2.14e-04	194	27	3	ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRKCA PRKCB WNT5A	2.14e-04	194	27	3	240d122dcb9dd1ab2867503ad85869853adcacae
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PXN PRKCA ABLIM1	2.14e-04	194	27	3	a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB ABLIM1 KMO	2.17e-04	195	27	3	f5bf4797972185afa76638293166abd536e5472f
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRKCB ABLIM1 KMO	2.17e-04	195	27	3	d77423d0ec64b397c6d1eec181c5fc0acaa92d63
ToppCell	mLN-(1)_T_cell-(14)_Tcm\|mLN / shred on region, Cell_type, and subtype	PXN PRKCA ABLIM1	2.31e-04	199	27	3	3222454da504e119c78e666b90cc669ff0335b1a
ToppCell	mLN-T_cell-Tcm\|mLN / Region, Cell class and subclass	PXN PRKCA ABLIM1	2.31e-04	199	27	3	b1237c8d1acad6737d8cb425dc4eb50724e2302c
Drug	12-hydroxydaphnetoxin	PRKCA PRKCB	1.35e-06	2	27	2	CID000099841
Drug	octahydromezerein	PRKCA PRKCB	4.06e-06	3	27	2	CID000164152
Drug	daphnetoxin	PRKCA PRKCB	8.11e-06	4	27	2	CID000119454
Drug	deca	PRKCA PRKCB RNF40	1.32e-05	39	27	3	CID000002993
Drug	12-deoxyphorbolphenylacetate-20-acetate	PRKCA PRKCB	1.35e-05	5	27	2	ctd:C029705
Drug	thymeleatoxin	PRKCA PRKCB	2.03e-05	6	27	2	ctd:C080287
Drug	ruboxistaurin	PRKCA PRKCB	2.03e-05	6	27	2	ctd:C099154
Drug	benzathine	EXTL3 ZBTB21	4.85e-05	9	27	2	CID000008793
Drug	Ro-31-8425	PRKCA PRKCB WNT5A	4.86e-05	60	27	3	CID000002404
Drug	sn-glycero-3-phosphoserine	PRKCA PRKCB	6.06e-05	10	27	2	CID000444182
Drug	Vitamin E	PRKCA PRKCB	6.06e-05	10	27	2	DB00163
Drug	Phosphatidylserines	PRKCA PRKCB	7.40e-05	11	27	2	ctd:D010718
Drug	D gap	PRKCA RNF40	7.40e-05	11	27	2	CID000126100
Drug	SB 202190; Down 200; 1uM; PC3; HT_HG-U133A	PXN PRKCA GDF11 KMO	7.85e-05	195	27	4	7058_DN
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	PRKCB EXTL3 GPR176 KMO	8.00e-05	196	27	4	3837_UP
Drug	radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; HL60; HT_HG-U133A	PXN PRKCA EXTL3 KMO	8.32e-05	198	27	4	6178_UP
Drug	bryostatin 1	PRKCA PRKCB	8.87e-05	12	27	2	ctd:C046785
Drug	NSC35770	PRKCA PRKCB HERC2	1.15e-04	80	27	3	CID000002800
Drug	RK-1409B	PRKCA PRKCB	1.41e-04	15	27	2	CID003036125
Drug	dansyl-DAG	PRKCA PRKCB	1.41e-04	15	27	2	CID000129493
Drug	1-stearoyl-2-arachidonylglycerol	PRKCA PRKCB	1.41e-04	15	27	2	CID006443869
Drug	1uu9	PRKCA PRKCB	1.61e-04	16	27	2	CID000002398
Drug	tert-Butyl Alcohol	PRKCA PRKCB	1.61e-04	16	27	2	ctd:D020002
Drug	AC1O517G	PRKCA PRKCB	1.61e-04	16	27	2	CID006450188
Drug	aurothioglucose	PRKCA PRKCB EXTL3	1.63e-04	90	27	3	CID000006104
Drug	Ct-15	PRKCA PRKCB	1.82e-04	17	27	2	CID003034917
Drug	daphnoretin	PRKCA PRKCB	1.82e-04	17	27	2	CID005281406
Drug	AC1L1JQC	PRKCA PRKCB	1.82e-04	17	27	2	CID000005157
Drug	AT-8	PRKCA PRKCB	1.82e-04	17	27	2	CID000025566
Drug	dipalmitin	PRKCA PRKCB	2.05e-04	18	27	2	CID000068149
Drug	Cgp-42700	PRKCA PRKCB	2.05e-04	18	27	2	CID000188390
Drug	Lop	SALL1 CLPX	2.05e-04	18	27	2	CID009547934
Drug	dihydrosterculic acid	PRKCA PRKCB	2.05e-04	18	27	2	CID000160788
Drug	TAPP-Br	PRKCA PRKCB	2.29e-04	19	27	2	CID000160326
Drug	sapintoxin A	PRKCA PRKCB	2.29e-04	19	27	2	CID000108085
Drug	SR121463	PRKCA PRKCB	2.29e-04	19	27	2	CID000158348
Drug	PM H	DPAGT1 EXTL3	2.54e-04	20	27	2	CID000445008
Drug	KS-619-1	PRKCA PRKCB	2.80e-04	21	27	2	CID000128369
Drug	K-259-2	PRKCA PRKCB	2.80e-04	21	27	2	CID006438946
Drug	debromoaplysiatoxin	PRKCA PRKCB	2.80e-04	21	27	2	CID000002967
Drug	broussochalcone A	PRKCA PRKCB	2.80e-04	21	27	2	CID006438825
Drug	ALT-711	PRKCA PRKCB	2.80e-04	21	27	2	CID000216304
Drug	C12E10	DPAGT1 EXTL3	2.80e-04	21	27	2	CID002724258
Drug	MDL 27,032	PRKCA PRKCB	2.80e-04	21	27	2	CID000163812
Drug	amphetamine	PRKCA PRKCB RNF40 ZBTB21	3.32e-04	284	27	4	CID000003007
Drug	L-656,224	PRKCA PRKCB	3.37e-04	23	27	2	CID000128132
Drug	AC1L4NFY	PRKCA PRKCB	3.37e-04	23	27	2	CID000160335
Drug	S)-bromoenol lactone	PRKCA PRKCB SALL1	3.72e-04	119	27	3	CID000002445
Drug	teleocidin B	DPAGT1 PRKCA PRKCB	4.09e-04	123	27	3	CID000072425
Drug	thiram	PRKCA PRKCB	4.67e-04	27	27	2	CID000005455
Drug	beta-tocopherol	PRKCA PRKCB	4.67e-04	27	27	2	CID000008989
Drug	IBDU	PRKCA PRKCB	4.67e-04	27	27	2	CID000022478
Drug	ilmofosine	PRKCA PRKCB	4.67e-04	27	27	2	CID000055008
Drug	pseudohypericin	PRKCA PRKCB	4.67e-04	27	27	2	CID005281751
Drug	C15720	PRKCA PRKCB	4.67e-04	27	27	2	CID000003979
Drug	bisindolylmaleimide II	PRKCA PRKCB	5.02e-04	28	27	2	CID000002397
Drug	bisindolylmaleimide V	PRKCA PRKCB	5.02e-04	28	27	2	CID000002400
Drug	aplysiatoxin	PRKCA PRKCB	5.02e-04	28	27	2	CID000040465
Drug	HBDDE	PRKCA PRKCB	5.02e-04	28	27	2	CID000003568
Drug	SC-10	PRKCA PRKCB	5.02e-04	28	27	2	CID000005175
Drug	NCDC	PRKCA PRKCB	5.02e-04	28	27	2	CID000001583
Drug	LiCl	PRKCA GDF11 WNT5A	5.26e-04	134	27	3	CID000433294
Drug	SQ22536	DPAGT1 PRKCA PRKCB	5.37e-04	135	27	3	CID000005270
Drug	AC1Q6DXY	PRKCA PRKCB	5.39e-04	29	27	2	CID000003719
Drug	Polychlorinated biphenyls	PRKCA PRKCB	5.39e-04	29	27	2	CID000006636
Drug	AC1L1B58	PRKCA PRKCB	5.39e-04	29	27	2	CID000001288
Drug	Anilino	PRKCA EXTL3	5.39e-04	29	27	2	CID000137550
Drug	chloroform	DPAGT1 PRKCA PRKCB	5.73e-04	138	27	3	CID000006212
Drug	Gf 109	PRKCA PRKCB	5.77e-04	30	27	2	CID000196144
Drug	mezerein	PRKCA PRKCB	5.77e-04	30	27	2	ctd:C011309
Drug	mevalonolactone	DPAGT1 EXTL3	5.77e-04	30	27	2	CID000010428
Drug	AC1L3G0K	PRKCA PRKCB	5.77e-04	30	27	2	CID000114822
Drug	12-deoxyphorbol 13-phenylacetate	PRKCA PRKCB	5.77e-04	30	27	2	CID000105100
Drug	cisplatin	PRKCA PRKCB HERC2	5.85e-04	139	27	3	CID000002767
Drug	Ro 31	PRKCA PRKCB WNT5A	6.10e-04	141	27	3	CID000214797
Drug	N,n,n-tms	PRKCA PRKCB	6.17e-04	31	27	2	CID006439410
Drug	CAS 68-19-9	PRKCA PRKCB RNF40	6.62e-04	145	27	3	CID000002891
Drug	CGS 9343B	PRKCA PRKCB	6.99e-04	33	27	2	CID000065909
Drug	naphthalenesulfonamide	PRKCA PRKCB	6.99e-04	33	27	2	CID000163571
Drug	AC1L1FGW	PRKCA PRKCB	6.99e-04	33	27	2	CID000003231
Drug	4-O-methyl-TPA	PRKCA PRKCB	7.42e-04	34	27	2	CID000072292
Drug	AC1NSKHR	PRKCA PRKCB	7.42e-04	34	27	2	CID005311362
Drug	h x mg	PRKCA PRKCB	7.42e-04	34	27	2	CID000001380
Drug	dihydrochloride	PRKCA PRKCB ZBTB21	8.64e-04	159	27	3	CID000070978
Drug	norathyriol	PRKCA PRKCB	8.79e-04	37	27	2	CID005281656
Drug	Fim 1	PRKCA PRKCB	8.79e-04	37	27	2	CID000132906
Drug	HOE 694	PRKCA PRKCB	8.79e-04	37	27	2	CID000123840
Drug	iso-H7	PRKCA PRKCB	8.79e-04	37	27	2	CID000001352
Drug	I5B1	PRKCA PRKCB	8.79e-04	37	27	2	CID005487705
Drug	lysosphingomyelin	PRKCA PRKCB GPR176	8.80e-04	160	27	3	CID000005263
Drug	CID5147932	PRKCA PRKCB	9.27e-04	38	27	2	CID005147932
Drug	Jmv 180	PRKCA PRKCB	9.27e-04	38	27	2	CID003035023
Drug	Ro 31-7549	PRKCA PRKCB	9.77e-04	39	27	2	CID000002403
Drug	12-deoxyphorbol 13-isobutyrate	PRKCA PRKCB	9.77e-04	39	27	2	CID000107855
Drug	C09179	PRKCA PRKCB	9.77e-04	39	27	2	CID000442082
Drug	Helveticoside [630-64-8]; Up 200; 7.4uM; PC3; HT_HG-U133A	PRKCA PRKCB KMO	9.79e-04	166	27	3	4327_UP
Drug	AC1L1KEH	PRKCA PRKCB	1.03e-03	40	27	2	CID000005462
Drug	digoxigenine	PRKCA PRKCB	1.03e-03	40	27	2	CID000015478
Drug	Go6983	PRKCA PRKCB	1.03e-03	40	27	2	CID000003499
Drug	1-stearoyl-2-arachidonoyl-sn-glycerol	PRKCA PRKCB	1.03e-03	40	27	2	CID000001398
Disease	Asthma, Occupational	PRKCA HERC2	3.61e-05	10	27	2	C0264423
Disease	endometrial carcinoma (is_marker_for)	PRKCA WNT5A	4.44e-04	34	27	2	DOID:2871 (is_marker_for)
Disease	dilated cardiomyopathy (is_implicated_in)	PRKCA PRKCB	7.11e-04	43	27	2	DOID:12930 (is_implicated_in)
Disease	congenital heart disease (implicated_via_orthology)	RNF40 RNF20	1.82e-03	69	27	2	DOID:1682 (implicated_via_orthology)
Disease	daytime rest measurement	PRKCA PRKCB KMO	2.42e-03	295	27	3	EFO_0007828
Disease	Cardiac Hypertrophy	PRKCA PRKCB	2.56e-03	82	27	2	C1383860
Disease	Cardiomegaly	PRKCA PRKCB	2.56e-03	82	27	2	C0018800
Disease	Adenocarcinoma of large intestine	PRKCA PRKCB	3.49e-03	96	27	2	C1319315
Disease	Vitiligo	HERC2 PARP12	3.85e-03	101	27	2	EFO_0004208
Disease	congestive heart failure (biomarker_via_orthology)	PRKCA PRKCB	4.31e-03	107	27	2	DOID:6000 (biomarker_via_orthology)
Disease	Glioblastoma Multiforme	PRKCA PRKCB	4.63e-03	111	27	2	C1621958
Disease	hypertension (implicated_via_orthology)	PRKCA PRKCB	6.10e-03	128	27	2	DOID:10763 (implicated_via_orthology)
Disease	bone mineral content measurement	PRKCB HERC2	6.29e-03	130	27	2	EFO_0007621
Disease	Neoplastic Cell Transformation	PXN WNT5A	7.16e-03	139	27	2	C0007621
Disease	severe acute respiratory syndrome, COVID-19	PXN PRKCA ABLIM1	7.71e-03	447	27	3	EFO_0000694, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
KDAVLTKCFHVFCFE	RNF40	956	O75150
KCFHVFCFECVKTRY	RNF20	936	Q5VTR2
STRFVKCEKCHHFFV	CLPX	121	O76031
KCEKCHHFFVVLSEA	CLPX	126	O76031
LRVQTKHFHIKCFTC	ABLIM1	111	O14639
FLKRHEECCVFFHKY	CMTR2	356	Q8IYT2
FCKVVKFLHKVFCSV	GPR176	116	Q14439
FCETCFKTKKHNTRH	HERC2	2731	O95714
CFVKEQCKAFPHHEF	DPAGT1	81	Q9H3H5
CFVVHKRCHEFVTFS	PRKCB	71	P05771
RKSCSFQDKCHRVHF	PARP12	281	Q9H0J9
AKKFHPEHFVCAFCL	PXN	551	P49023
ISVKCSSFHFKSHCV	KMO	286	O15229
QKSAKLFHCHKCFFT	CHAMP1	56	Q96JM3
SHFHERHKCINFFVK	EXTL3	871	O43909
CCHFHFSPKVMFTKV	GDF11	161	O95390
TSDEAFFKHKCRFCA	SALL1	441	Q9NSC2
RLSFCASHIIKHFFC	OR1L4	166	Q8NGR5
CFVVHKRCHEFVTFS	PRKCA	71	P17252
HVFHKACLQAFEKFT	RNF32	146	Q9H0A6
RETVSKFHVHFCRKC	CCDC110	326	Q8TBZ0
SCVFFGCFTEKHIHK	USP51	251	Q70EK9
ACDICHKRFHTNFKV	ZBTB21	576	Q9ULJ3
CFHVFRTSCNLKSHK	ZNF558	241	Q96NG5
EHRDFCFFTIKFLKH	SUGP2	376	Q8IX01
QFKTVQTERCHCKFH	WNT5A	346	P41221
CIECHSKIKDFASHF	ZNF280C	621	Q8ND82
HVKDLFHCEKCNRSF	ZNF131	256	P52739