Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

5.81e-0934395GO:0008395
GeneOntologyMolecularFunctioncoumarin 7-hydroxylase activity

CYP2A6 CYP2A7 CYP2A13

6.89e-093393GO:0008389
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

3.90e-0849395GO:0016712
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.28e-0724394GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.11e-0727394GO:0008391
GeneOntologyMolecularFunctionaromatase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6

6.23e-0735394GO:0070330
GeneOntologyMolecularFunctionmonooxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.86e-06115395GO:0004497
GeneOntologyMolecularFunctiondolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity

ALG10B ALG10

3.72e-062392GO:0106073
GeneOntologyMolecularFunctionheme binding

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.19e-05154395GO:0020037
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.62e-05164395GO:0046906
GeneOntologyMolecularFunctioniron ion binding

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.71e-05166395GO:0005506
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

3.62e-05194395GO:0016705
GeneOntologyMolecularFunctionG protein-coupled opioid receptor activity

OPRL1 OPRM1

7.76e-057392GO:0004985
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

TMC2 TMC5

5.58e-0418392GO:0008381
GeneOntologyMolecularFunctionglucosyltransferase activity

ALG10B ALG10

8.38e-0422392GO:0046527
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor binding

LANCL1 SACS

2.00e-0334392GO:0050750
GeneOntologyMolecularFunctionneuropeptide binding

OPRL1 OPRM1

2.37e-0337392GO:0042923
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH2 MYH4

2.50e-0338392GO:0000146
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

LANCL1 SACS

2.63e-0339392GO:0070325
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

TMC2 OPRM1

3.64e-0346392GO:0005245
GeneOntologyMolecularFunctiongated channel activity

ANO5 TMC2 TMC5 OPRM1

3.99e-03334394GO:0022836
GeneOntologyMolecularFunctionlipid transporter activity

SLCO1B3 ANO5 SPNS2

6.56e-03196393GO:0005319
GeneOntologyMolecularFunctionHsp70 protein binding

CYP2B6 SACS

6.73e-0363392GO:0030544
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2A14 LANCL1 OR2A5 OR52L2P OPRL1 OPRM1

6.92e-03884396GO:0004930
GeneOntologyMolecularFunctionhexosyltransferase activity

B3GNT5 ALG10B ALG10

8.04e-03211393GO:0016758
GeneOntologyBiologicalProcessepoxygenase P450 pathway

CYP2A6 CYP2A7 CYP2A13 CYP2B6

7.79e-0822394GO:0019373
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

CYP2A6 CYP2A7 CYP2A13

7.43e-0710393GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

CYP2A6 CYP2A7 CYP2A13

7.43e-0710393GO:0009804
GeneOntologyBiologicalProcessxenobiotic metabolic process

SLCO1B3 CYP2A6 CYP2A7 CYP2A13 CYP2B6

6.64e-06141395GO:0006805
GeneOntologyBiologicalProcessarachidonate metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.15e-0668394GO:0019369
GeneOntologyBiologicalProcesscellular response to xenobiotic stimulus

SLCO1B3 CYP2A6 CYP2A7 CYP2A13 CYP2B6

5.90e-05222395GO:0071466
GeneOntologyBiologicalProcesslong-chain fatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.70e-05124394GO:0001676
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6

9.84e-05128394GO:0033559
GeneOntologyBiologicalProcesssensory perception

OR2A14 OR2A5 TMC2 OR52L2P SPNS2 ALG10B ALG10 OPRL1 OPRM1

1.38e-041072399GO:0007600
GeneOntologyBiologicalProcessheme metabolic process

SLCO1B3 CYP2A6 CYP2A13

1.45e-0454393GO:0042168
GeneOntologyBiologicalProcessicosanoid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.47e-04142394GO:0006690
GeneOntologyBiologicalProcessporphyrin-containing compound metabolic process

SLCO1B3 CYP2A6 CYP2A13

2.29e-0463393GO:0006778
GeneOntologyBiologicalProcessG protein-coupled opioid receptor signaling pathway

OPRL1 OPRM1

2.68e-0413392GO:0038003
GeneOntologyBiologicalProcesssecondary metabolic process

CYP2A6 CYP2A7 CYP2A13

2.75e-0467393GO:0019748
GeneOntologyBiologicalProcessnegative regulation of cAMP-mediated signaling

OPRL1 OPRM1

3.12e-0414392GO:0043951
GeneOntologyBiologicalProcesstetrapyrrole metabolic process

SLCO1B3 CYP2A6 CYP2A13

3.55e-0473393GO:0033013
GeneOntologyBiologicalProcessmuscle filament sliding

MYH2 MYH4

3.60e-0415392GO:0030049
GeneOntologyBiologicalProcessolefinic compound metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.63e-04180394GO:0120254
GeneOntologyBiologicalProcesssensory perception of sound

TMC2 SPNS2 ALG10B ALG10

5.21e-04198394GO:0007605
GeneOntologyBiologicalProcessnegative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

OPRL1 OPRM1

5.23e-0418392GO:0106072
GeneOntologyBiologicalProcessactin-myosin filament sliding

MYH2 MYH4

5.23e-0418392GO:0033275
GeneOntologyBiologicalProcesspigment metabolic process

SLCO1B3 CYP2A6 CYP2A13

7.44e-0494393GO:0042440
GeneOntologyBiologicalProcessdolichol-linked oligosaccharide biosynthetic process

ALG10B ALG10

7.86e-0422392GO:0006488
GeneOntologyBiologicalProcesssympathetic nervous system development

PLXNA4 NF1

9.37e-0424392GO:0048485
GeneOntologyBiologicalProcessdolichol metabolic process

ALG10B ALG10

9.37e-0424392GO:0019348
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

TMC2 SPNS2 ALG10B ALG10

1.04e-03238394GO:0050954
GeneOntologyBiologicalProcessregulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

OPRL1 OPRM1

1.10e-0326392GO:0106070
GeneOntologyCellularComponentendoplasmic reticulum membrane

KDELR2 CYP2A6 CYP2A7 ANO5 CYP2A13 CYP2B6 CYP39A1 ALG10B ALG10 HHATL

9.65e-0512933910GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

KDELR2 CYP2A6 CYP2A7 ANO5 CYP2A13 CYP2B6 CYP39A1 ALG10B ALG10 HHATL

1.00e-0412993910GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

KDELR2 CYP2A6 CYP2A7 ANO5 CYP2A13 CYP2B6 CYP39A1 ALG10B ALG10 HHATL

1.20e-0413273910GO:0042175
GeneOntologyCellularComponentmuscle myosin complex

MYH2 MYH4

4.00e-0416392GO:0005859
GeneOntologyCellularComponentmyosin filament

MYH2 MYH4

9.90e-0425392GO:0032982
GeneOntologyCellularComponentmyosin II complex

MYH2 MYH4

1.24e-0328392GO:0016460
GeneOntologyCellularComponentcytoplasmic microtubule

CYP2A6 CYP2A7 CYP2A13

1.95e-03133393GO:0005881
MousePhenodecreased intestinal cholesterol absorption

CYP2A6 CYP2A7 CYP2A13

9.55e-0617353MP:0002647
MousePhenoabnormal intestinal cholesterol absorption

CYP2A6 CYP2A7 CYP2A13

1.36e-0519353MP:0002645
MousePhenoabnormal xenobiotic pharmacokinetics

SLCO1B3 CYP2A6 CYP2A13

5.57e-0530353MP:0008875
MousePhenoabnormal intestinal lipid absorption

CYP2A6 CYP2A7 CYP2A13

6.16e-0531353MP:0005342
MousePhenoabnormal cochlear hair cell physiology

TMC2 ALG10B ALG10

1.33e-0440353MP:0004432
MousePhenoabnormal bile salt homeostasis

CYP2A6 CYP2A7 CYP2A13

2.16e-0447353MP:0005365
MousePhenoabnormal hair cell physiology

TMC2 ALG10B ALG10

2.45e-0449353MP:0003879
MousePhenoimpaired behavioral response to morphine

OPRL1 OPRM1

2.71e-0410352MP:0009757
MousePhenoabsent cochlear microphonics

ALG10B ALG10

2.71e-0410352MP:0004413
MousePhenoabnormal intestinal absorption

CYP2A6 CYP2A7 CYP2A13

4.25e-0459353MP:0001666
MousePhenobleb

ALG10B ALG10

4.67e-0413352MP:0008854
MousePhenoabnormal behavioral response to morphine

OPRL1 OPRM1

4.67e-0413352MP:0020159
DomainCyt_P450_E_grp-I_CYP2A-like

CYP2A6 CYP2A7 CYP2A13

3.10e-084383IPR008067
DomainCYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.03e-0757385PS00086
Domain-

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.12e-07583851.10.630.10
Domainp450

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.12e-0758385PF00067
DomainCyt_P450

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.34e-0760385IPR001128
DomainCyt_P450_E_grp-I

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.04e-0645384IPR002401
DomainCyt_P450_CS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.97e-0653384IPR017972
DomainAlg10

ALG10B ALG10

4.03e-062382IPR016900
DomainDIE2_ALG10

ALG10B ALG10

4.03e-062382PF04922
DomainOpioid_rcpt

OPRL1 OPRM1

2.41e-054382IPR001418
DomainTMC

TMC2 TMC5

1.12e-048382PF07810
DomainTMC

TMC2 TMC5

1.12e-048382IPR012496
DomainMyosin_N

MYH2 MYH4

4.16e-0415382IPR004009
DomainMyosin_N

MYH2 MYH4

4.16e-0415382PF02736
DomainMyosin_tail_1

MYH2 MYH4

6.04e-0418382PF01576
DomainMyosin_tail

MYH2 MYH4

6.04e-0418382IPR002928
DomainMyosin-like_IQ_dom

MYH2 MYH4

6.74e-0419382IPR027401
Domain-

MYH2 MYH4

6.74e-04193824.10.270.10
DomainMYOSIN_MOTOR

MYH2 MYH4

2.71e-0338382PS51456
DomainMyosin_head

MYH2 MYH4

2.71e-0338382PF00063
DomainMyosin_head_motor_dom

MYH2 MYH4

2.71e-0338382IPR001609
DomainMYSc

MYH2 MYH4

2.71e-0338382SM00242
DomainARM-type_fold

URB1 NF1 ARMH3 PI4KA

4.84e-03339384IPR016024
DomainIQ

MYH2 MYH4

9.17e-0371382PF00612
DomainIQ

MYH2 MYH4

1.18e-0281382SM00015
DomainRho_GTPase_activation_prot

PLXNA4 NF1

1.38e-0288382IPR008936
DomainIQ_motif_EF-hand-BS

MYH2 MYH4

1.44e-0290382IPR000048
DomainIQ

MYH2 MYH4

1.53e-0293382PS50096
DomainMFS

SLCO1B3 SPNS2

2.03e-02108382PS50850
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

5.44e-0911304M27130
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.15e-0912304MM14847
PathwayREACTOME_FATTY_ACIDS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

4.99e-0818304MM14841
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.43e-0723304M5372
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.83e-0762305M39653
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.04e-0725304MM14846
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.15e-0764305M5650
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.51e-0766305MM14839
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.44e-06104305M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.56e-06105305MM14842
PathwayREACTOME_FATTY_ACIDS

CYP2A7 CYP2A13 CYP2B6

3.89e-0615303M27126
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP2A6 CYP2A7 BPNT2 CYP2A13 CYP2B6 CYP39A1

5.71e-06219306MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

CYP2A6 CYP2A7 BPNT2 CYP2A13 CYP2B6 CYP39A1

5.86e-06220306M10320
PathwayKEGG_RETINOL_METABOLISM

CYP2A6 CYP2A7 CYP2A13 CYP2B6

9.69e-0664304M9488
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.55e-0572304M9257
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

3.82e-05183305M39588
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS

CYP2A6 CYP2A13

4.36e-055302M47808
PathwayWP_NICOTINE_METABOLISM_IN_LIVER_CELLS

CYP2A6 CYP2B6

6.53e-056302M39600
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

CYP2A6 CYP2A7 CYP2A13

1.69e-0451303M17726
PathwayKEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST

ALG10B ALG10

2.38e-0411302M47614
PathwayWP_VALPROIC_ACID_PATHWAY

CYP2A6 CYP2B6

2.85e-0412302M39371
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

CYP2A6 CYP2A13

1.38e-0326302MM15190
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

CYP2A6 CYP2B6

1.96e-0331302M39476
PathwayWP_PREGNANE_X_RECEPTOR_PATHWAY

CYP2A6 CYP2B6

2.09e-0332302M39567
PathwayWP_OPIOID_RECEPTOR_PATHWAYS

OPRL1 OPRM1

3.41e-0341302M48338
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

SLCO1B3 CYP39A1

3.92e-0344302M499
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

SLCO1B3 CYP39A1

4.09e-0345302MM14751
PathwayKEGG_N_GLYCAN_BIOSYNTHESIS

ALG10B ALG10

4.28e-0346302M11079
Pubmed

Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.50e-1244041970547
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

9.51e-121740527197076
Pubmed

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.25e-1164047668294
Pubmed

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.25e-1164048587134
Pubmed

Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

5.23e-11740414630516
Pubmed

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

CYP2A6 CYP2A7 CYP2A13

1.41e-09340331645370
Pubmed

Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.

CYP2A6 CYP2A13 CYP2B6

1.41e-0934033219345
Pubmed

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934033346244
Pubmed

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934032733794
Pubmed

A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934038297477
Pubmed

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934038188299
Pubmed

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934038484736
Pubmed

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934038250953
Pubmed

The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934032703500
Pubmed

Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934031417950
Pubmed

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

CYP2A6 CYP2A7 CYP2A13

1.41e-09340324045421
Pubmed

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

CYP2A6 CYP2A7 CYP2A13

1.41e-09340332987105
Pubmed

Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.

CYP2A6 CYP2A13 CYP2B6

1.41e-0934031973143
Pubmed

Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.

CYP2A6 CYP2A7 CYP2A13

1.41e-09340322217847
Pubmed

Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934032765478
Pubmed

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

CYP2A6 CYP2A7 CYP2A13

1.41e-0934032415518
Pubmed

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.

CYP2A6 CYP2A7 CYP2A13

1.41e-09340322890016
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.63e-094440512745259
Pubmed

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.03e-091540429968852
Pubmed

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.

CYP2A6 CYP2A7 CYP2A13

5.63e-0944039408084
Pubmed

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.

CYP2A6 CYP2A7 CYP2A13

5.63e-09440310490589
Pubmed

A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.

CYP2A6 CYP2A7 CYP2A13

5.63e-0944037565685
Pubmed

Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.

CYP2A6 CYP2A13 CYP2B6

5.63e-09440324494203
Pubmed

Molecular genetics of the human cytochrome P450 monooxygenase superfamily.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

7.17e-09204049890157
Pubmed

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.78e-087040515128046
Pubmed

Resveratrol improves health and survival of mice on a high-calorie diet.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.20e-082640417086191
Pubmed

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

CYP2A6 CYP2A7 CYP2A13

4.92e-0874039630227
Pubmed

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.

CYP2A6 CYP2A7 CYP2A13

1.18e-07940337838304
Pubmed

Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.

CYP2A6 CYP2A13 CYP2B6

5.08e-071440319290787
Pubmed

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

SLCO1B3 CYP2A6 CYP2A7 CYP2A13

5.67e-075740417208939
Pubmed

Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain.

OPRL1 OPRM1

1.29e-06240223652222
Pubmed

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

CYP2A6 CYP2A7

1.29e-06240212325023
Pubmed

Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.

CYP2A6 CYP2B6

1.29e-06240228931220
Pubmed

Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist.

OPRL1 OPRM1

1.29e-06240215748148
Pubmed

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

CYP2A6 CYP2A13

1.29e-06240222696418
Pubmed

Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.

CYP2A6 CYP2A13

1.29e-06240230876690
Pubmed

CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.

CYP2A6 CYP2A13

1.29e-06240221395539
Pubmed

Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.

CYP2A6 CYP2A13

1.29e-06240212162851
Pubmed

Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.

CYP2A6 CYP2A13

1.29e-0624021302041
Pubmed

Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.

CYP2A6 CYP2A13

1.29e-0624028395817
Pubmed

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.

CYP2A6 CYP2A13

1.29e-06240225804444
Pubmed

Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

CYP2A6 CYP2A13

1.29e-0624021520280
Pubmed

Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism.

CYP2A6 CYP2B6

1.29e-06240218004205
Pubmed

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.

CYP2A6 CYP2A13

1.29e-06240223917075
Pubmed

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.

CYP2A6 CYP2A13

1.29e-06240230222954
Pubmed

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

CYP2A6 CYP2A7

1.29e-06240216636685
Pubmed

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.

CYP2A6 CYP2A13

1.29e-0624027543189
Pubmed

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.

CYP2A6 CYP2A13

1.29e-06240227902773
Pubmed

Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin.

CYP2A6 CYP2B6

1.29e-06240228886044
Pubmed

Characterization and regulation of sex-specific mouse steroid hydroxylase genes.

CYP2A6 CYP2A13

1.29e-0624022372744
Pubmed

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

CYP2A6 CYP2A7

1.29e-0624022322567
Pubmed

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.

CYP2A6 CYP2A13

1.29e-06240221473878
Pubmed

The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.

CYP2A6 CYP2A13

1.29e-0624027581481
Pubmed

Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.

CYP2A6 CYP2A13

1.29e-06240230154104
Pubmed

Expression of CYP2A genes in human liver and extrahepatic tissues.

CYP2A7 CYP2A13

1.29e-06240210353262
Pubmed

Expression and alternative splicing of the cytochrome P-450 CYP2A7.

CYP2A6 CYP2A7

1.29e-0624027864805
Pubmed

Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.

CYP2A6 CYP2A13

1.29e-06240228298240
Pubmed

Implications of OPRM1 and CYP2B6 variants on treatment outcomes in methadone-maintained patients in Ontario: Exploring sex differences.

CYP2B6 OPRM1

1.29e-06240234910759
Pubmed

Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

CYP2A6 CYP2A13

1.29e-0624026309775
Pubmed

CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.

CYP2A6 CYP2B6

1.29e-06240219371316
Pubmed

Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.

CYP2A6 CYP2A13

1.29e-06240221418183
Pubmed

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

CYP2A6 CYP2A13

1.29e-06240222262919
Pubmed

Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease.

OPRL1 OPRM1

1.29e-06240230152845
Pubmed

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

CYP2A6 CYP2A13

1.29e-06240225635819
Pubmed

Genetic variation between mice in their metabolism of coumarin and its derivatives.

CYP2A6 CYP2A13

1.29e-062402566237
Pubmed

Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling.

MYH2 MYH4

1.29e-06240221102503
Pubmed

CYP2B6 and OPRM1 gene variations predict methadone-related deaths.

CYP2B6 OPRM1

1.29e-06240221158011
Pubmed

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.

CYP2A6 CYP2A13

1.29e-06240219923441
Pubmed

Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.

CYP2A6 CYP2A13

1.29e-06240212499123
Pubmed

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.

CYP2A6 CYP2A13

1.29e-0624028611142
Pubmed

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.

CYP2A6 CYP2A13

1.29e-06240222497566
Pubmed

Coumarin toxicity in different strains of mice.

CYP2A6 CYP2A13

1.29e-062402665441
Pubmed

Determinants of the rate of nicotine metabolism and effects on smoking behavior.

CYP2A6 CYP2B6

1.29e-06240217015050
Pubmed

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

CYP2A6 CYP2A13

1.29e-06240224104196
Pubmed

OPRM1 and CYP2B6 gene variants as risk factors in methadone-related deaths.

CYP2B6 OPRM1

1.29e-06240220668445
Pubmed

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.

CYP2A6 CYP2A13

1.29e-06240226363552
Pubmed

Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.

CYP2A6 CYP2A13

1.29e-0624022712571
Pubmed

Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.

CYP2A6 CYP2A13 CYP2B6

1.35e-061940312721789
Pubmed

Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.

MYH2 MYH4

3.87e-06340226059207
Pubmed

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

CYP2A6 CYP2A13

3.87e-06340218602936
Pubmed

Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.

CYP2A6 CYP2A13

3.87e-06340218068688
Pubmed

CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.

CYP2A6 CYP2A7

3.87e-06340211960914
Pubmed

Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.

CYP2A6 CYP2A13

3.87e-0634027849402
Pubmed

A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).

ALG10B ALG10

3.87e-06340224303013
Pubmed

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.

CYP2A6 CYP2A13

3.87e-06340220840855
Pubmed

Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.

CYP2A6 CYP2A13

3.87e-06340222552773
Pubmed

Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.

MYH2 MYH4

3.87e-0634028145163
Pubmed

Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.

CYP2A6 CYP2A13

3.87e-06340211106424
Pubmed

Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes.

CYP2A6 CYP2B6

3.87e-06340226648056
Pubmed

Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.

CYP2A6 CYP2A13

3.87e-06340217303623
Pubmed

ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression.

MYH2 MYH4

3.87e-06340223339872
Pubmed

CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients.

CYP2A6 CYP2B6

3.87e-06340219779319
Pubmed

A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.

CYP2A6 CYP2A13

3.87e-06340221252290
Pubmed

Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.

CYP2A6 CYP2A13

3.87e-06340225478736
Pubmed

The myosin alkali light chain proteins and their genes.

MYH2 MYH4

3.87e-0634023904738
InteractionCYP2A7 interactions

CYP2A6 CYP2A7 CYP2A13

5.23e-093363int:CYP2A7
InteractionCYP2A13 interactions

CYP2A7 CYP2A13

4.63e-056362int:CYP2A13
InteractionC3orf18 interactions

NF1 ARMH3 SACS PI4KA

5.15e-05115364int:C3orf18
InteractionCYP2A6 interactions

CYP2A6 CYP2A7

1.11e-049362int:CYP2A6
InteractionRAB39B interactions

BPNT2 CTLA4 OPRL1

1.36e-0456363int:RAB39B
InteractionSPPL3 interactions

MYH4 B3GNT5 CYP39A1 PI4KA SPNS2 HHATL OPRL1 OPRM1

1.37e-04886368int:SPPL3
Cytoband19q13.2

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.30e-0516440419q13.2
Cytoband7q35

OR2A14 OR2A5

1.07e-03554027q35
CytobandEnsembl 112 genes in cytogenetic band chr7q35

OR2A14 OR2A5

1.53e-0366402chr7q35
CytobandEnsembl 112 genes in cytogenetic band chr17p13

MYH2 MYH4 SPNS2

3.41e-03346403chr17p13
Cytoband17p13.1

MYH2 MYH4

4.79e-0311840217p13.1
GeneFamilyCytochrome P450 family 2

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.33e-07352841001
GeneFamilyAlpha-1,2-glucosyltransferases

ALG10B ALG10

2.31e-062282448
GeneFamilyOpioid receptors

OPRL1 OPRM1

1.39e-054282245
GeneFamilyTransmembrane channel likes

TMC2 TMC5

6.44e-0582821135
GeneFamilyMyosin heavy chains

MYH2 MYH4

2.40e-04152821098
GeneFamilyOlfactory receptors, family 2

OR2A14 OR2A5

1.32e-02113282149
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

TMEM225 SACS

3.18e-02181282694
CoexpressionWENG_POR_DOSAGE

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.24e-0730404MM1199
CoexpressionWENG_POR_TARGETS_LIVER_UP

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.29e-0653404MM1203
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP

CYP2A6 CYP2A7 CYP2A13 NF1 OPRM1

5.19e-05267405MM984
CoexpressionAtlasliver

SLCO1B3 CYP2A6 CYP2A7 CYP2B6 CYP39A1 KLKB1

4.80e-05419346liver
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

PLXNA4 CYP2A7 CYP2B6 TMC5 SPNS2

6.53e-07190395756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLCO1B3 CYP2A7 CYP2A13 CYP2B6 TMC5

6.70e-07191395e96184aee03175fd9f1da11fa2b89d95ba58b817
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A7 CYP2A13 CYP2B6 TMC5

7.05e-07193395605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Club|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CYP2A6 CYP2A7 CYP2A13 CYP2B6 TMC5

8.20e-07199395111cfd589ec6795075d8d88d7664bfb23eba5bf6
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CYP2A6 CYP2A7 CYP2A13 CYP2B6 TMC5

8.20e-07199395d583290a1d288b749ad17bc501c1487268c6551c
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CYP2A6 CYP2A7 CYP2A13 CYP2B6 TMC5

8.20e-071993952b17694cffbec28a2c8f165dfcff6bab94aa0f4c
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A13 CYP2B6 TMC5

1.07e-05157394c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 CYP2B6 TMC5

1.21e-051623945c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH2 MYH4 ANO5 HHATL

1.60e-051743944a6e04b4f12b87c15fa1409989cbe32c43736369
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.60e-0517439442f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCellAdult-Epithelial-club_cell-D175|Adult / Lineage, Cell type, age group and donor

PLXNA4 CYP2B6 TMC5 SPNS2

1.71e-05177394d652b7d84fe6aa38319d8d5adc72c70441bd0088
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 CYP2B6 SPNS2

1.75e-05178394f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 CYP2B6 SPNS2

1.75e-0517839435a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

CYP2A6 CYP2A7 CYP2B6 TMC5

1.87e-05181394c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellControl-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.03e-051853946814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCellControl-Epithelial-Club|World / Disease state, Lineage and Cell class

CYP2A6 CYP2A7 CYP2B6 TMC5

2.08e-051863949798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A13 CYP2B6 TMC5

2.30e-05191394cd709bbcd320373468ea7f058ee5fda8a067b5d0
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 CYP2B6 TMC5

2.30e-0519139423776c7302cead3881b39127398f3b3e0d27885e
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

CYP2A6 CYP2A7 CYP2B6 TMC5

2.30e-051913943c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellNS-critical-d_16-33-Epithelial-Secretory-diff|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CYP2A7 CYP2A13 CYP2B6 TMC5

2.35e-0519239402b11233b4da2d85b96498b3c6e22e3a31b3d049
ToppCellControl-Epithelial-Club|Control / Disease state, Lineage and Cell class

CYP2A6 CYP2A7 CYP2B6 TMC5

2.35e-05192394d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 CYP2B6 TMC5

2.40e-051933942bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellGoblet|World / shred by cell class for turbinate

KDELR2 CYP2A6 CYP2A13 CYP2B6

2.45e-0519439403b62e7cff5e7a6e7bd7d9dda273c74bf9c1f42e
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A6 CYP2A7 CYP2B6 TMC5

2.45e-05194394a58841b34efe673671a9a059238e044a7254b279
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A6 CYP2A7 CYP2B6 TMC5

2.45e-051943940cd4363627acd419e00d6d32f6dce10430aa6487
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 CYP2B6 SPNS2

2.50e-05195394dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CYP2A6 CYP2A7 CYP2B6 TMC5

2.50e-05195394b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCellnormal_Lung-Epithelial_cells-Club|normal_Lung / Location, Cell class and cell subclass

CYP2A6 CYP2A7 CYP2A13 TMC5

2.50e-05195394b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Club|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.55e-051963944e4c632db73b1340d80bf40a7657cb4821084d3c
ToppCellBronchial_Biopsy-Epithelial-Club|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

KDELR2 CYP2A13 CYP2B6 TMC5

2.55e-05196394057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCellBronchial_Biopsy-Epithelial-Club|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

KDELR2 CYP2A13 CYP2B6 TMC5

2.60e-051973943f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCellBiopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CYP2A6 CYP2A7 CYP2A13 TMC5

2.65e-05198394a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CYP2A6 CYP2A13 CYP2B6 TMC5

2.65e-051983945d57acbe0d245f8bd217eeea07af060092898fbd
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A13 CYP2B6 TMC5

2.71e-051993941e693d7bb481bf03a943b460a69787229625d7b1
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CYP2A6 CYP2A7 CYP2B6 TMC5

2.71e-05199394a8bfc0b93ad9968cf52a25be86995ffe436bd636
ToppCelldistal-1-Epithelial-Club|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP2A6 CYP2A7 CYP2A13 TMC5

2.71e-051993948f0a72a95d0310ef2324c6975495c294b5a47cc8
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Transitional_AT2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CYP2A6 CYP2A7 CYP2B6 TMC5

2.71e-05199394b44d74895846e2ac144438b73e0ca91e3949c16c
ToppCellBiopsy_IPF-Epithelial-SCGB3A2+_SCGB1A1+|Biopsy_IPF / Sample group, Lineage and Cell type

CYP2A6 CYP2A13 CYP2B6 TMC5

2.71e-05199394c6150f5fe2ce4466149a4d553acb907034a72efb
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Transitional_AT2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CYP2A6 CYP2A7 CYP2B6 TMC5

2.71e-051993944b374a5de82b4614d3d8a00202ea6cb8f1fd8104
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Transitional_AT2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CYP2A6 CYP2A7 CYP2B6 TMC5

2.71e-051993949e8231c9007d8d963805a4c99e0905538ceb9b60
ToppCelldistal-Epithelial-Club-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP2A6 CYP2A7 CYP2A13 TMC5

2.71e-05199394685cefbe6ff5db8b578e50b5849524ac2f347d0c
ToppCellControl-Endothelial-Endothelial-Activated_Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

B3GNT5 SPNS2 HDX

1.62e-04121393a5962d1c476e6966870832b72d511607e047248b
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYH4 ANO5 OPRM1

1.78e-04125393d05556ea185c15815a4f8643f1c01185badbeece
ToppCellTCGA-Bile_Duct-Solid_Tissue_Normal-Bile_duct_normal_tissue-Bile_duct_normal_tissue-4|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SLCO1B3 CYP2A7 CYP39A1

2.48e-04140393744bfab59601efb23450a9bc87bcf541f77ad6b2
ToppCellTCGA-Bile_Duct-Solid_Tissue_Normal-Bile_duct_normal_tissue|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SLCO1B3 CYP2A7 CYP39A1

2.48e-04140393bad9aa342bd5244263873936b55cbb95f69bdb5a
ToppCellTCGA-Bile_Duct-Solid_Tissue_Normal|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SLCO1B3 CYP2A7 CYP39A1

2.48e-041403932c35c7d8b7e1101d1b74d7ce3da2364c5602c846
ToppCellTCGA-Bile_Duct-Solid_Tissue_Normal-Bile_duct_normal_tissue-Bile_duct_normal_tissue|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SLCO1B3 CYP2A7 CYP39A1

2.48e-04140393deb9d97f1260fe1c4ad4ec3e1ecb111d79f13058
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYH4 ANO5 OPRM1

2.70e-0414439371107275767a0728541a3695715c44874b3e5efc
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Mucinous_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

CYP2A6 CYP2A7 CYP2A13

2.75e-041453931e52e3c615b49e7388cd58a04e74cafac9552447
ToppCelldroplet-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 ITGAD KLKB1

2.75e-04145393f142b86d4da5b71c189da46cbc4beebdc387ffee
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH2 URB1 TMEM121B

3.35e-04155393c58a5fb8d853f12204e961d633e83452eb12a659
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH2 URB1 TMEM121B

3.35e-041553939cb8c42c2e451b2d4dcd7154a4b1bfd21bbb7ea8
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 CYP2B6

3.47e-041573936ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 CYP39A1 KLKB1

3.67e-04160393c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYH4 ANO5 OPRM1

3.74e-04161393dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH2 TMC2 KLKB1

3.81e-04162393bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_3|343B / Donor, Lineage, Cell class and subclass (all cells)

B3GNT5 KLKB1 TMEM121B

3.81e-041623930acb8f7b51bf422d4f4f8e99bd10360163ae4eb7
ToppCellClub_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CYP2A6 CYP2A13 CYP2B6

3.95e-041643934e25e6362ef793b08de2f4d1dccb6b1fc9c072a5
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 ANO5 OPRM1

4.09e-04166393548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 ANO5 OPRM1

4.09e-0416639380e164a89d22098cabe4a99a78283ba69ea0561e
ToppCellClub_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

CYP2A6 CYP2A13 TMC5

4.16e-04167393dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 CYP39A1 KLKB1

4.23e-04168393b98af4043dfa5dfa4413e482879fad88de484675
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 CYP39A1 KLKB1

4.23e-04168393073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCelldroplet-Liver-HEPATOCYTES|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 CYP39A1 KLKB1

4.31e-04169393f195467438c589f87224bde7da720dea072d110c
ToppCelldroplet-Liver-HEPATOCYTES-1m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLCO1B3 CYP39A1 KLKB1

4.31e-041693937785cab967a33560830c394c918d6ce625103858
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA4 TMC5 KLKB1

4.31e-0416939312bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYH4 ANO5 OPRM1

4.38e-041703938ab67e2b6e30fdf9e9a2c02e31d4df34e751a3ed
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A7 CYP2A13 CYP2B6

4.46e-0417139325c1979e972c959e1ce4c57804f976f53a247ad7
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A7 CYP2A13 CYP2B6

4.46e-04171393fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CTLA4 NF1 B3GNT5

4.53e-04172393eee45759284baa3ed77da6a5fbcc4f8f6c553106
ToppCell3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CYP39A1 KLKB1 HDX

4.61e-0417339385083b9ce20351dd69aa2327ad087b848b4307ff
ToppCellCOVID-19-kidney-PCT-S3-2|kidney / Disease (COVID-19 only), tissue and cell type

SLCO1B3 CYP2A6 CYP2B6

4.69e-041743935aa2fb631505600f37d2b87b02def7be139dc262
ToppCellTCGA-Colorectal-Recurrent_Tumor|TCGA-Colorectal / Sample_Type by Project: Shred V9

CYP2A6 CYP2A7 KLKB1

4.77e-041753937f74961436f88c0e380819095e6104489914d765
ToppCellTCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

CYP2A6 CYP2A7 KLKB1

4.77e-04175393bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GPR137B CTLA4 ITGAD

4.93e-04177393945b2d0723a0a35c767604ae607d2c2d53bf0c82
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A7 URB1 TMC5

4.93e-04177393779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A7 URB1 TMC5

4.93e-041773930f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCellTCGA-Liver-Solid_Tissue_Normal|TCGA-Liver / Sample_Type by Project: Shred V9

SLCO1B3 CYP2B6 CYP39A1

5.09e-041793937046f0a426e45fe1b41a25721ee1e33f6fc7f9e3
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver|TCGA-Liver / Sample_Type by Project: Shred V9

SLCO1B3 CYP2B6 CYP39A1

5.09e-041793930e22e840f43ca81a7543dcf33ec17a741cdf7f37
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue|TCGA-Liver / Sample_Type by Project: Shred V9

SLCO1B3 CYP2B6 CYP39A1

5.09e-0417939317ba1eedb6ebf039d3b11d099351d0ac6363c8d1
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue-2|TCGA-Liver / Sample_Type by Project: Shred V9

SLCO1B3 CYP2B6 CYP39A1

5.09e-04179393a20bb3ace5be10c5aef330e9268c0ba55f8fee23
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-skeletal_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH2 MYH4 HHATL

5.18e-04180393cea62fc006d68c3815c88bf17ec2617d7e41c3d2
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLXNA4 CYP2B6 TMC5

5.18e-04180393b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CYP2B6 TMC5 SPNS2

5.35e-04182393215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

BPNT2 CTLA4 ARMH3

5.43e-04183393310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

BPNT2 CTLA4 ARMH3

5.43e-04183393fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCellCV-Healthy-7|Healthy / Virus stimulation, Condition and Cluster

URB1 ALG10B ALG10

5.61e-041853931979d189c204f4c2893e3170a514ee7d5523406c
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR137B ITGAD OPRM1

5.61e-0418539348de4d9fad55077732bf64eca4919103ecbc1512
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A7 CYP2B6

5.78e-04187393f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Proximal_secretory_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CYP2A6 CYP2A13 TMC5

5.87e-0418839307705bed928683470a52c8ccfa40ffb9a0971318
ToppCellIPF-Epithelial-Club|IPF / Disease state, Lineage and Cell class

CYP2A6 CYP2B6 TMC5

5.97e-04189393f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A13 TMC5

6.06e-041903932fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A13 CYP2B6 TMC5

6.15e-0419139314851529025cfc2b665f71ebad04150ec543da7a
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A13 CYP2B6 TMC5

6.15e-04191393e14b22e882ac92acf8c8b6ee997ef8e799c7a8d5
ToppCell18-Distal-Epithelial-Secretory_progenitor|Distal / Age, Tissue, Lineage and Cell class

CYP2A6 CYP2A7 CYP2A13

6.24e-041923939fae988ecd2ef1231bfd42a678a4903517694cbe
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Club|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CYP2A13 CYP2B6 TMC5

6.24e-04192393044c7ae56da17cacf2705efa8ac2c8aeba6cfeee
ToppCellcellseq-Epithelial-Epithelial_Glandular-Goblet|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A13 CYP2B6 TMC5

6.34e-0419339371bf8fb5314b79cb30f4eb9c8459b21f10cd6d35
ToppCellcellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A6 CYP2A7 TMC5

6.34e-04193393525e0de0f25f3308daf49e7d4c8774562f1f40ad
ToppCellcellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CYP2A6 CYP2A7 TMC5

6.34e-041933932d18f39615043dfbff120a00f6540ffa93082c83
ToppCellClub_cells|World / lung cells shred on cell class, cell subclass, sample id

CYP2A6 CYP2A7 TMC5

6.34e-041933939d3165dc5763a07a7d873f497624d9d6528fa2db
Drugpropoxyphene

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1 OPRL1 OPRM1

1.98e-1167397CID000010100
DrugNSC35549

CYP2A6 CYP2A7 CYP2A13 OPRL1 OPRM1

2.91e-1022395CID000411697
Drug2'-methoxyacetophenone

CYP2A6 CYP2A7 CYP2A13

4.65e-093393CID000068481
Drugpolybrominated biphenyl

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.17e-0844395CID000042948
Drug9-hydroxybenzo(a)pyrene

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

3.05e-0853395CID000028598
DrugBP-4,5-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

6.27e-0861395CID000037786
Drugchlorzoxazone

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

7.39e-0863395CID000002733
Drugpiperonyl butoxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.01e-0767395CID000005794
DrugC14845

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.25e-0727394CID011954064
DrugBP-9,10-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.25e-0727394CID000037456
DrugBrn 4136738

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.25e-0727394CID000050331
Drug4-bromophenol

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CTLA4

1.26e-0770395CID000007808
Drugcarteolol

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.45e-0772395CID000002583
Drug9-OH-BaP-4,5-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.46e-0728394CID000115064
Drug7-hydroxycoumarin

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.79e-0775395CID005281426
Drugdebrisoquine

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.79e-0775395CID000002965
Drug11-H-14,15-EETA

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.95e-0730394CID011954058
Drug19-hydroxytestosterone

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.95e-0730394CID000150968
Drugtrimipramine

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.47e-0780395CID000005584
DrugBP-7,8-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.55e-0732394CID000037455
Drugnorbuprenorphine

CYP2A6 CYP2B6 OPRL1 OPRM1

2.90e-0733394CID000114976
Drug12(13)-EpOME

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.28e-0734394CID000001416
DrugTCEO

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.28e-0734394CID000028167
DrugAC1O5XSP

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.28e-0734394CID006442739
Drugdiosmetin

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

3.35e-0785395CID005281612
DrugAC1L1CJI

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.70e-0735394CID000001929
Drugmephenytoin

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

3.99e-0788395CID000004060
Drug15-H-11,12-EETA

CYP2A6 CYP2A7 CYP2A13 CYP2B6

4.16e-0736394CID011954042
DrugAC1L3NGJ

CYP2A6 CYP2A7 CYP2A13 CYP2B6

4.16e-0736394CID000092121
DrugAC1L1ILY

MYH2 CYP2A6 OPRL1 OPRM1

5.20e-0738394CID000004635
Drugtienilic acid

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

5.26e-0793395CID000038409
Druglansoprazole

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

5.26e-0793395CID000003883
Drug11,14,15-THET

CYP2A6 CYP2A7 CYP2A13 CYP2B6

5.79e-0739394CID006439531
Drugbromobenzene

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

6.49e-0797395CID000007961
DrugPCB 77

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

6.83e-0798395CID000036187
DrugAC1L1KIN

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

7.56e-07100395CID000005516
DrugD-702

CYP2A6 CYP2A13 CYP2B6

7.59e-0711393CID000054077
Drug11,12,15-trihydroxyeicosatrienoic acid

CYP2A6 CYP2A7 CYP2A13 CYP2B6

7.85e-0742394CID006439610
DrugSparteinum

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

7.94e-07101395CID000003966
Drugnaphthalene-1,2-dihydrodiol

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.04e-0645394CID000000362
DrugC14802

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.24e-0647394CID011954053
Drugd 6-20

CYP2A6 CYP2A13 CYP2B6

1.31e-0613393CID000161569
DrugC14800

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.35e-0648394CID011954051
Drugnitro-L

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.35e-0648394CID000006849
Drugproadifen hydrochloride

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.45e-06114395CID000004910
Drug19-HETE

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.47e-0649394CID006439528
Drugbromobenzene-3,4-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.47e-0649394CID000108121
Drugbromobenzene-2,3-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.60e-0650394CID003036760
Drug6-hydroxymelatonin

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.60e-0650394CID000001864
Drug1,1-dichloroethylene epoxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.60e-0650394CID000119521
DrugAC1Q7AUJ

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.65e-06117395CID000003303
DrugN-nitrosomethylaniline

CYP2A6 CYP2A7 CYP2A13

1.67e-0614393CID000011957
DrugAC1Q7BBT

SLCO1B3 CYP2B6 CYP39A1

1.67e-0614393CID000086545
Drug8-MOP

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.72e-06118395CID000004114
Drugnaphthalene epoxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.73e-0651394CID000108063
Drugbenzphetamine

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.79e-06119395CID000002341
Drugnaphthalene

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.11e-06123395CID000000931
Drugdichloroacetaldehyde

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.19e-0654394CID000006576
Drugchloroacetyl chloride

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.35e-0655394CID000006577
Drughexobarbital

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.47e-06127395CID000003608
Drugchloral hydrate

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

2.66e-06129395CID000002707
Drug1,2-dihydroxynaphthalene

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.72e-0657394CID000011318
Drugnicotine imine

CYP2A6 CYP2A13

2.86e-062392ctd:C034629
Drugpropargyl ether

CYP2A6 CYP2A13

2.86e-062392ctd:C531209
Drugalpha-nicotyrine

CYP2A6 CYP2A13

2.86e-062392ctd:C008615
Drugverbenone

CYP2A6 CYP2B6

2.86e-062392ctd:C052875
DrugHempa

CYP2A6 CYP2A13

2.86e-062392ctd:D006492
DrugN-nitrosoguvacoline

CYP2A6 CYP2A13

2.86e-062392ctd:C036676
Drugbromoacetaldehyde

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.92e-0658394CID000105131
Drug1,1-dichloroethylene

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.34e-0660394CID000006366
Drugaminoglutethimide

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

3.58e-06137395CID000002145
DrugAC1L1QMT

CYP2A6 CYP2B6 OPRL1

3.72e-0618393CID000008270
DrugD 703

CYP2A6 CYP2A13 CYP2B6

3.72e-0618393CID000054088
Drugcoumarin

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

3.84e-06139395CID000000323
Druganiline

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

4.27e-06142395CID000006115
DrugD 617

CYP2A6 CYP2A13 CYP2B6

4.42e-0619393CID000093168
DrugNSC9700

MYH2 CYP2A6 CYP2A7 MYH4 CYP2A13 CYP2B6 CYP39A1 KLKB1

5.05e-06578398CID000005408
DrugNSC76436

CYP2A6 OPRL1 OPRM1

5.19e-0620393CID000002828
Drug5,6-epoxyeicosatrienoic acid

CYP2A6 CYP2A7 CYP2A13 CYP2B6

5.53e-0668394CID000001778
Drug8(9)-EET

CYP2A6 CYP2A7 CYP2A13 CYP2B6

5.86e-0669394CID000001901
Drugmethoxyresorufin

CYP2A6 CYP2A13 CYP2B6 CYP39A1

5.86e-0669394CID000119220
Drugnifedipine

MYH2 CYP2A6 CYP2A7 MYH4 CYP2A13 CYP2B6 CYP39A1

5.91e-06415397CID000004485
Drug1h1q

CYP2A6 CYP2A7 CYP2A13 CYP2B6

6.21e-0670394CID000001540
Drug1-aminobenzotriazole

CYP2A6 CYP2A13 CYP2B6 CYP39A1

6.57e-0671394CID000001367
Drug1,2-dibromoethane

CYP2A6 CYP2A7 CYP2A13 CYP2B6

6.57e-0671394CID000007839
Drug2,2,2-trichloroethanol

CYP2A6 CYP2A7 CYP2A13 CYP2B6

7.35e-0673394CID000008259
Drugchloral

CYP2A6 CYP2A7 CYP2A13 CYP2B6

7.35e-0673394CID000006407
Drug2-propyl-4-pentenoic acid

CYP2A6 CYP2B6

8.57e-063392ctd:C045022
Drug5-hydroxyvalproate

CYP2A6 CYP2B6

8.57e-063392ctd:C091208
Drug4-hydroxyvalproate

CYP2A6 CYP2B6

8.57e-063392ctd:C091207
Drughexafluoron

CYP2A6 CYP2B6

8.57e-063392ctd:C058039
Drugparaoxon

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

8.62e-06164395CID000009395
DrugC20H32O4

CYP2A6 CYP2A7 CYP2A13 CYP2B6

9.57e-0678394CID000001440
DrugBP-7,8-diol

CYP2A6 CYP2A7 CYP2A13 CYP2B6

9.57e-0678394CID000025892
Drugfelodipine

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

9.97e-06169395CID000003333
DrugTranylcypromine

CYP2A6 CYP2A13 CYP2B6

1.04e-0525393ctd:D014191
Drugaminopyrine

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.06e-05171395CID000006009
Drug4-nitrophenol

CYP2A6 CYP2A13 CYP2B6 SACS CYP39A1

1.25e-05177395CID000000980
Drugrifampicin

SLCO1B3 CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.26e-05306396CID005381226
Drugmetyrapone

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP39A1

1.32e-05179395CID000004174
Diseasenicotine metabolite ratio

CYP2A6 CYP2A7 CYP2B6

4.30e-0712383EFO_0007794
Diseasecaffeine metabolite measurement

CYP2A6 CYP2A7 CYP2B6

1.88e-0619383EFO_0007872
DiseaseLong Qt Syndrome 2

ALG10B ALG10

4.84e-063382C3150943
DiseaseCHGA cleavage product measurement

TMC2 KLKB1

1.61e-055382EFO_0007909
Diseasenonsyndromic deafness (implicated_via_orthology)

ALG10B ALG10

2.41e-056382DOID:0050563 (implicated_via_orthology)
DiseaseMorphine Abuse

OPRL1 OPRM1

3.38e-057382C0600272
DiseaseMorphine Dependence

OPRL1 OPRM1

3.38e-057382C0026552
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH2 MYH4

7.22e-0510382DOID:0110454 (implicated_via_orthology)
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH2 MYH4

7.22e-0510382DOID:0111269 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH2 MYH4

7.22e-0510382DOID:0080719 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH2 MYH4

7.22e-0510382DOID:0111602 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH2 MYH4

7.22e-0510382DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH2 MYH4

7.22e-0510382DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH2 MYH4

7.22e-0510382DOID:0080326 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH2 MYH4

7.22e-0510382DOID:0111596 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH2 MYH4

1.06e-0412382DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH2 MYH4

1.06e-0412382DOID:2106 (implicated_via_orthology)
DiseaseTOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)

CYP2A6 CYP2B6

1.06e-0412382C1861063
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH2 MYH4

1.25e-0413382DOID:397 (implicated_via_orthology)
DiseaseHepatitis C

CYP2A6 OPRM1

1.68e-0415382C0019196
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH2 MYH4

1.68e-0415382DOID:0050646 (implicated_via_orthology)
Diseaseacute myeloid leukemia (is_implicated_in)

CYP2B6 CTLA4 NF1

1.75e-0484383DOID:9119 (is_implicated_in)
Diseaselupus nephritis (is_implicated_in)

CTLA4 KLKB1

2.44e-0418382DOID:0080162 (is_implicated_in)
Diseasesciatic neuropathy (biomarker_via_orthology)

MYH4 NF1 OPRL1

2.84e-0499383DOID:11446 (biomarker_via_orthology)
DiseaseAlcoholic Intoxication, Chronic

CYP2A13 CYP2B6 OPRL1 OPRM1

3.85e-04268384C0001973
Diseasesmoking behavior

PLXNA4 CYP2A6 CYP2A7 CYP2B6

9.49e-04341384EFO_0004318
Diseasetestosterone measurement

SLCO1B3 MYH2 URB1 NF1 SPNS2 OPRL1 OPRM1

1.08e-031275387EFO_0004908

Protein segments in the cluster

PeptideGeneStartEntry
FMLSTYQTDFILVLK

CASTOR3

126

Q8NAP1
LKMLNLFYQTFSLIS

CYP2B6

196

P20813
EYESSLTLKMFLFQF

ANO5

551

Q75V66
FYLKNLVMTTLNLFI

CYP2A6

286

P11509
NLLITFLKYSSIVMQ

ARMH3

366

Q5T2E6
RKILQFLLAYSMSFK

ALG10B

231

Q5I7T1
FLLAYSMSFKNLSML

ALG10B

236

Q5I7T1
TLLTTLMFFNTKYFL

QRICH1

621

Q2TAL8
KVLSLFYSLFNPMLN

OR2A14

271

Q96R47
MKTATNIYIFNLALA

OPRM1

101

P35372
YFKLQTFVRSLILAM

HDX

626

Q7Z353
MYNLVSLNSLKFTEL

HHATL

441

Q9HCP6
AFLTLYNLTQDMKYL

LANCL1

331

O43813
FANILLYIQRTKSMF

EIF3L

336

Q9Y262
MSLIINTFYSNKEIF

HSP90AB4P

1

Q58FF6
SQLYYFMTLTLSDLK

PLXNA4

946

Q9HCM2
LYQKSAMKTLAQLFS

MYH2

611

Q9UKX2
LINKLDFAMSTYLLS

PI4KA

881

P42356
VLSNRKMFYLLKTAF

BPNT2

111

Q9NX62
QKVLSLFYSLFNPML

OR2A5

271

Q96R48
LFALMQYSNLLKIHF

ITGAD

186

Q13349
FVDSFYNLTLKLLMQ

B3GNT5

161

Q9BYG0
FYLKNLVMTTLNLFF

CYP2A13

286

Q16696
FYLKNLMMSTLNLFI

CYP2A7

286

P20853
MILFKQATYFISLFA

KLKB1

1

P03952
FYSFLLTAVSLSKML

CTLA4

176

P16410
LYPVTVNMLFNKSLF

CYP39A1

166

Q9NYL5
DLFMNTLYLKYSNIL

SACS

3186

Q9NZJ4
LFTSFISLYNTSMKV

KDELR2

51

P33947
KMKTATNIYIFNLAL

OPRL1

81

P41146
MNLDSFFSFLLKSLI

OR52L2P

1

Q8NGH6
FFSFLLKSLIMALSN

OR52L2P

6

Q8NGH6
LMNLYFTQVIFKAKS

GPR137B

131

O60478
SYQQPLSIFMLKNLF

TMEM121B

491

Q9BXQ6
LFTKNTRTLMLSVFY

SPNS2

221

Q8IVW8
LYQKSAMKTLAFLFS

MYH4

611

Q9Y623
TFLKMLLTAVQLLYS

URB1

1446

O60287
RKILQFLLAYSMSFK

ALG10

231

Q5BKT4
FLLAYSMSFKNLSML

ALG10

236

Q5BKT4
SFLTSMISFLFQLLY

SLCO1B3

411

Q9NPD5
QLFLKYFTLFMNLLN

NF1

1101

P21359
LSFLLNLILGMKFTY

TMEM225

76

Q6GV28
KLTFNQLLTRFSAYM

TMC5

606

Q6UXY8
LLMFLAIYYLNSVSK

TMC2

766

Q8TDI7