Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Cezanne-2	OTUD7A OTUD7B	1.90e-05	2	82	2	IPR033477
Domain	GLYCOSYL_HYDROL_F31_2	GANAB MYORG	1.89e-04	5	82	2	PS00707
Domain	Znf_A20	OTUD7A OTUD7B	3.94e-04	7	82	2	IPR002653
Domain	Glyco_hydro_31	GANAB MYORG	3.94e-04	7	82	2	IPR000322
Domain	ZF_A20	OTUD7A OTUD7B	3.94e-04	7	82	2	PS51036
Domain	zf-A20	OTUD7A OTUD7B	3.94e-04	7	82	2	PF01754
Domain	Glyco_hydro_31	GANAB MYORG	3.94e-04	7	82	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	GANAB MYORG	3.94e-04	7	82	2	PS00129
Domain	ZnF_A20	OTUD7A OTUD7B	3.94e-04	7	82	2	SM00259
Domain	Glyco_trans_14	GCNT1 GCNT2	5.24e-04	8	82	2	IPR003406
Domain	Branch	GCNT1 GCNT2	5.24e-04	8	82	2	PF02485
Domain	-	RABEPK FBXO42 KLHL34	1.22e-03	48	82	3	2.120.10.80
Domain	Kelch_2	RABEPK FBXO42	1.44e-03	13	82	2	IPR011498
Domain	OTU	OTUD7A OTUD7B	1.44e-03	13	82	2	PF02338
Domain	Kelch_2	RABEPK FBXO42	1.44e-03	13	82	2	PF07646
Domain	Kelch-typ_b-propeller	RABEPK FBXO42 KLHL34	1.82e-03	55	82	3	IPR015915
Domain	OTU	OTUD7A OTUD7B	1.93e-03	15	82	2	PS50802
Domain	OTU_dom	OTUD7A OTUD7B	1.93e-03	15	82	2	IPR003323
Domain	Kelch_1	RABEPK FBXO42 KLHL34	3.61e-03	70	82	3	PF01344
Domain	Kelch_1	RABEPK FBXO42 KLHL34	3.61e-03	70	82	3	IPR006652
Domain	JmjC	KDM6A UTY	4.94e-03	24	82	2	PF02373
Pubmed	SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements.	SAFB SRSF1 SRSF9	7.82e-07	8	85	3	9671816
Pubmed	Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity.	GCNT1 GCNT2	5.90e-06	2	85	2	12954635
Pubmed	Abnormalities caused by carbohydrate alterations in Ibeta6-N-acetylglucosaminyltransferase-deficient mice.	GCNT1 GCNT2	5.90e-06	2	85	2	16107727
Pubmed	Differential requirements for core2 glucosaminyltransferase for endothelial L-selectin ligand function in vivo.	GCNT1 GCNT2	5.90e-06	2	85	2	11490014
Pubmed	Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family.	GCNT1 GCNT2	5.90e-06	2	85	2	7579796
Pubmed	An H-YDb epitope is encoded by a novel mouse Y chromosome gene.	KDM6A UTY	5.90e-06	2	85	2	8944031
Pubmed	Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.	KDM6A UTY	5.90e-06	2	85	2	18434530
Pubmed	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.	KDM6A UTY	5.90e-06	2	85	2	27533081
Pubmed	Positive and negative selection on mammalian Y chromosomes.	KDM6A UTY	5.90e-06	2	85	2	15758204
Pubmed	Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.	KDM6A UTY	5.90e-06	2	85	2	31097364
Pubmed	An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.	GCNT1 GCNT2	5.90e-06	2	85	2	15882971
Pubmed	Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.	GCNT1 GCNT2	5.90e-06	2	85	2	8449405
Pubmed	SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis.	SRSF1 SRSF9	5.90e-06	2	85	2	23592547
Pubmed	Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.	FZD4 PTCH1	1.77e-05	3	85	2	27823583
Pubmed	Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.	GCNT1 GCNT2	1.77e-05	3	85	2	9915862
Pubmed	The UTX gene escapes X inactivation in mice and humans.	KDM6A UTY	1.77e-05	3	85	2	9499428
Pubmed	GlcNAc-transferase V and core 2 GlcNAc-transferase expression in the developing mouse embryo.	GCNT1 GCNT2	1.77e-05	3	85	2	8720078
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	S100A9 GANAB SRSF1 SPTBN1 PAFAH1B3 AP1M1 BUB3 ECPAS SRSF9	1.79e-05	607	85	9	39147351
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	PSORS1C1 TTLL4 PAN2 PTCH1 STAT2	2.17e-05	136	85	5	25429064
Pubmed	SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma.	SALL4 PTCH1	3.53e-05	4	85	2	38062245
Pubmed	Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.	KDM6A UTY	3.53e-05	4	85	2	9854018
Pubmed	Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma.	SALL4 HDAC2	3.53e-05	4	85	2	28411180
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM6A UTY	3.53e-05	4	85	2	32732223
Pubmed	A BEN-domain-containing protein associates with heterochromatin and represses transcription.	SALL4 HDAC2	3.53e-05	4	85	2	21914818
Pubmed	Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer.	SALL4 KDM6A	3.53e-05	4	85	2	36877334
Pubmed	The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation.	SRSF1 SRSF9	3.53e-05	4	85	2	10022843
Pubmed	Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.	KDM6A UTY	3.53e-05	4	85	2	10767340
Pubmed	The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes.	ZNF75A ZNF75CP	3.53e-05	4	85	2	8661144
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	BLMH S100A9 SAFB GANAB SRSF1 IPO8 SPTBN1 AP1M1 URB2 BUB3 ECPAS SRSF9 PCMT1	4.12e-05	1425	85	13	30948266
Pubmed	Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes.	SALL4 HDAC2	5.87e-05	5	85	2	21103394
Pubmed	Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease.	LRIG1 PTCH1	5.87e-05	5	85	2	35508126
Pubmed	A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription.	PTCH1 HDAC2	5.87e-05	5	85	2	21177534
Pubmed	A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs.	SRSF1 SRSF9	5.87e-05	5	85	2	2030943
Pubmed	Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation.	FZD4 PTCH1	5.87e-05	5	85	2	37774709
Pubmed	Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.	STAT2 HDAC2	5.87e-05	5	85	2	25812002
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	BLMH S100A9 SAFB SRSF1 SPG7 SPTBN1 BUB3 SRSF9 HDAC2	7.56e-05	731	85	9	29298432
Pubmed	Functional association of human Ki-1/57 with pre-mRNA splicing events.	SRSF1 SRSF9	8.80e-05	6	85	2	19523114
Pubmed	Pentoxifylline administration changes protein expression profile of coronary artery disease patients.	S100A9 PCMT1	8.80e-05	6	85	2	21839816
Pubmed	Autoimmunity to isomerized histone H2B in systemic lupus erythematosus.	TLR9 PCMT1	8.80e-05	6	85	2	22967069
Pubmed	OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.	HDAC2 OTUD7B	8.80e-05	6	85	2	34050636
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	BLMH GANAB SRSF1 PHF20 IPO8 PAFAH1B3 FAAP100 TOP3A PCMT1 USP47 HDAC2	1.17e-04	1155	85	11	20360068
Pubmed	UTX Affects Neural Stem Cell Proliferation and Differentiation through PTEN Signaling.	KDM6A UTY	1.23e-04	7	85	2	29551674
Pubmed	Tumor Architecture and Notch Signaling Modulate Drug Response in Basal Cell Carcinoma.	LRIG1 PTCH1	1.23e-04	7	85	2	29395868
Pubmed	The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.	SAFB SRSF9	1.23e-04	7	85	2	11118435
Pubmed	Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.	OTUD7A OTUD7B	1.23e-04	7	85	2	18281465
Pubmed	Polymorphisms in innate immunity genes and risk of childhood leukemia.	ATG9B CCR3 TLR9 STAT2 SECTM1	1.55e-04	206	85	5	20438785
Pubmed	Risk of meningioma and common variation in genes related to innate immunity.	ATG9B CCR3 TLR9 STAT2 SECTM1	1.59e-04	207	85	5	20406964
Pubmed	Common variation in genes related to innate immunity and risk of adult glioma.	ATG9B CCR3 TLR9 STAT2 SECTM1	1.62e-04	208	85	5	19423540
Pubmed	FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA.	SRSF1 SRSF9	1.64e-04	8	85	2	35194031
Pubmed	TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways.	TLR9 STAT2	1.64e-04	8	85	2	24598055
Pubmed	WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase.	BUB3 HDAC2	1.64e-04	8	85	2	15388328
Pubmed	UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death.	KDM6A UTY	1.64e-04	8	85	2	36412518
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	SRSF1 IPO8 SPTBN1 AP1M1 BUB3 ECPAS SRSF9 HDAC2	1.71e-04	638	85	8	33239621
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	SAFB GANAB SRSF1 MORN1 AP1M1 BUB3 ECPAS SRSF9	2.00e-04	653	85	8	33742100
Pubmed	Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.	LRIG1 PTCH1	2.10e-04	9	85	2	25842978
Pubmed	UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.	KDM6A UTY	2.10e-04	9	85	2	23028370
Pubmed	Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice.	ITGA7 PTCH1	2.10e-04	9	85	2	21602886
Pubmed	The SR protein family.	SRSF1 SRSF9	2.10e-04	9	85	2	19857271
Pubmed	UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.	KDM6A UTY	2.10e-04	9	85	2	22949634
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SRSF1 ECPAS KDM6A SRSF9 HDAC2	2.10e-04	220	85	5	35785414
Pubmed	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	AMT BHMT2 PCMT1	2.39e-04	49	85	3	19161160
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KDM6A UTY PCMT1	2.54e-04	50	85	3	37974198
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	S100A9 SAFB GANAB SRSF1 SPTBN1 PAN2 BUB3 SRSF9 PCMT1 HDAC2	3.09e-04	1082	85	10	38697112
Pubmed	Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.	SALL4 HDAC2	3.20e-04	11	85	2	29263092
Pubmed	Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development.	FZD4 PTCH1	3.20e-04	11	85	2	18948417
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	BLMH SAFB SRSF1 SRSF9 PCMT1	3.39e-04	244	85	5	29884807
Pubmed	Regulation of alternative splicing by SRrp86 and its interacting proteins.	SAFB SRSF1 SRSF9	3.75e-04	57	85	3	14559993
Pubmed	A novel ubiquitin ligase is deficient in Fanconi anemia.	FAAP100 TOP3A	3.83e-04	12	85	2	12973351
Pubmed	A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.	FAAP100 TOP3A	3.83e-04	12	85	2	16116422
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM6A UTY	4.52e-04	13	85	2	14660691
Pubmed	UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.	KDM6A UTY	4.52e-04	13	85	2	22192413
Pubmed	A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).	SRSF1 SRSF9	4.52e-04	13	85	2	20516191
Pubmed	MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.	FAAP100 TOP3A	5.27e-04	14	85	2	20347429
Pubmed	Genome-wide association study in Han Chinese identifies three novel loci for human height.	TMEM132C STAT2	5.27e-04	14	85	2	23456168
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	SALL4 KDM6A HDAC2	5.52e-04	65	85	3	22496869
Pubmed	The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.	S100A9 SAFB SPTBN1	5.52e-04	65	85	3	32521226
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	S100A9 RFTN1 SRSF1 SYT3 SPTBN1 BUB3 PCMT1	5.56e-04	580	85	7	35676659
Pubmed	Common body mass index-associated variants confer risk of extreme obesity.	RFTN1 FTO	6.07e-04	15	85	2	19553259
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SAFB SPTBN1 BUB3 ECPAS KDM6A SRSF9 USP47 OTUD7B	6.18e-04	774	85	8	15302935
Pubmed	Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.	GANAB SRSF1 SPTBN1 PCMT1	6.39e-04	159	85	4	34537242
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	S100A9 SAFB SRSF1 AGO3 SRSF9 HDAC2	6.62e-04	430	85	6	38172120
Pubmed	KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.	KDM6A UTY	6.93e-04	16	85	2	35212626
Pubmed	SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.	USP47 OTUD7B	6.93e-04	16	85	2	29891922
Pubmed	Role of topoisomerase IIbeta in the expression of developmentally regulated genes.	TENM3 HDAC2	6.93e-04	16	85	2	16923961
Pubmed	Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation.	CRYBA4 BFSP2	6.93e-04	16	85	2	15593327
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	S100A9 RFTN1 SAFB SRSF1 URB2 BUB3 SRSF9 PCMT1 HDAC2	6.99e-04	989	85	9	36424410
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	GANAB MAN1C1	7.84e-04	17	85	2	2355006
Pubmed	Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC.	S100A9 ANXA10 PCMT1	8.06e-04	74	85	3	31436131
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	GANAB SRSF1 SPTBN1 BUB3 ECPAS SRSF9 PCMT1 HDAC2	8.24e-04	809	85	8	32129710
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	BLMH EPHX2 S100A9 MELTF GANAB SPTBN1 BHMT2 AP1M1 SECTM1	8.46e-04	1016	85	9	19056867
Pubmed	Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.	SPTBN1 BHMT2 PCMT1	8.71e-04	76	85	3	8288233
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM6A UTY	8.80e-04	18	85	2	12023983
Pubmed	FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.	FAAP100 TOP3A	8.80e-04	18	85	2	22343915
Pubmed	Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning.	BHMT2 SALL4	8.80e-04	18	85	2	30559277
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	BLMH SAFB GANAB SRSF1 PAFAH1B3 URB2 SRSF9 PCMT1 HDAC2	8.93e-04	1024	85	9	24711643
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	URB2 CSMD2 KDM6A UTY ADCY2 RYR2 USP47	9.70e-04	638	85	7	31182584
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	OTUD7A OTUD7B	9.83e-04	19	85	2	23827681
Pubmed	Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3.	CRYBA4 BFSP2	9.83e-04	19	85	2	31847788
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SRSF1 AGO3 TTLL4 AP1M1 BUB3 SOWAHC STAT2 USP47 SAMD4A	9.83e-04	1038	85	9	26673895
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	BLMH GANAB IPO8 SPTBN1 SRSF9 PCMT1 HDAC2	1.05e-03	647	85	7	26618866
GeneFamily	Glucosaminyl (N-acetyl) transferases/xylosyltransferases	GCNT1 GCNT2	2.51e-04	8	55	2	441
GeneFamily	RNA binding motif containing\|Serine and arginine rich splicing factors	SRSF1 SRSF9	5.88e-04	12	55	2	737
GeneFamily	OTU domain containing	OTUD7A OTUD7B	1.20e-03	17	55	2	669
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6A UTY	2.40e-03	24	55	2	485
ToppCell	(1)_T_cells-(1)_T_CD4_naive\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	EPHX2 LINS1 ATG9B CCDC66 SPTBN1 CA6	2.02e-06	195	85	6	d3fa551bc6f5ee5890af1040415e61ecd5d46201
Computational	Neighborhood of XRCC5	SAFB GANAB SRSF1 BUB3 SRSF9 PCMT1 HDAC2	8.58e-05	235	49	7	MORF_XRCC5
Computational	Neighborhood of DEK	SAFB GANAB SRSF1 BUB3 SRSF9 PCMT1 HDAC2	1.77e-04	264	49	7	MORF_DEK
Computational	Neighborhood of MAP2K2	GANAB BUB3 SRSF9 PCMT1 HDAC2	3.20e-04	132	49	5	MORF_MAP2K2
Computational	Neighborhood of EIF3S2	SAFB GANAB BUB3 SRSF9 PCMT1 HDAC2	8.29e-04	246	49	6	MORF_EIF3S2
Computational	Neighborhood of PPP1CC	SAFB SRSF1 BUB3 SRSF9 HDAC2	9.11e-04	166	49	5	MORF_PPP1CC
Computational	Neighborhood of RAD23A	SAFB GANAB SRSF1 BUB3 SRSF9 PCMT1 HDAC2	9.34e-04	348	49	7	MORF_RAD23A
Drug	Triamcinolone [124-94-7]; Down 200; 10.2uM; PC3; HT_HG-U133A	FZD4 SAFB SPTBN1 FBXO42 ANXA10 PTCH1 FAAP100 TOP3A	7.03e-07	198	84	8	5835_DN
Drug	2-propylpentanoic acid; Up 200; 500uM; MCF7; HT_HG-U133A	OLFML2A ITPKC TENM3 SPTBN1 FBXO42 PTCH1 KDM6A	7.88e-06	195	84	7	6999_UP
Drug	Famprofazone [22881-35-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A	S100A9 OLFML2A IPO8 MAN1C1 SPTBN1 C8orf44 KDM6A	7.88e-06	195	84	7	3834_DN
Drug	Tranylcypromine hydrochloride [1986-47-6]; Down 200; 23.6uM; MCF7; HT_HG-U133A	EPHX2 S100A9 AMT PHF20 LRIG1 KDM6A TOP3A	7.88e-06	195	84	7	2264_DN
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Up 200; 12.2uM; PC3; HT_HG-U133A	SRSF1 PKD2L2 TTLL4 GCNT1 ITGA7 STAT2 SAMD4A	7.88e-06	195	84	7	4016_UP
Drug	Clopamide [636-54-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	EPHX2 S100A9 OLFML2A TTLL4 TOP3A RYR2 SAMD4A	8.42e-06	197	84	7	5402_DN
Drug	CGX 0596987; Up 200; 20uM; MCF7; HT_HG-U133A	OLFML2A MORN1 BHMT2 ITGA7 PTCH1 RYR2 SECTM1	8.42e-06	197	84	7	6412_UP
Drug	0179445-0000 [211246-22-9]; Down 200; 1uM; PC3; HT_HG-U133A	MELTF ANXA10 ITGA7 PTCH1 FAAP100 STAT2 SAMD4A	8.70e-06	198	84	7	3736_DN
Drug	Pentetic acid [67-43-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A	RFTN1 TENM3 TTLL4 SPTBN1 GCNT1 UTY SECTM1	9.29e-06	200	84	7	5264_DN
Drug	Securinine [5610-40-2]; Down 200; 18.4uM; HL60; HT_HG-U133A	AMT IPO8 TRIM9 MAN1C1 PTCH1 UTY	6.77e-05	187	84	6	2729_DN
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; PC3; HT_HG-U133A	OLFML2A SPTBN1 ANXA10 ADCY2 STAT2 RYR2	7.61e-05	191	84	6	3803_DN
Drug	Propoxycaine hydrochloride [550-83-4]; Down 200; 12uM; PC3; HT_HG-U133A	IPO8 SPTBN1 FBXO42 ANXA10 KDM6A UTY	7.83e-05	192	84	6	7155_DN
Drug	Doxycycline hydrochloride [10592-13-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A	RFTN1 SPTBN1 GCNT2 SOWAHC UTY TOP3A	8.06e-05	193	84	6	3479_DN
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	S100A9 OLFML2A ECPAS KDM6A UTY RYR2	8.29e-05	194	84	6	4727_DN
Drug	Oxyphenbutazone [129-20-4]; Down 200; 12.4uM; HL60; HT_HG-U133A	AMT PHF20 TRIM9 URB2 TOP3A STAT2	8.29e-05	194	84	6	6160_DN
Drug	radicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A	FZD4 SAFB PAN2 URB2 SOWAHC TOP3A	8.53e-05	195	84	6	6938_DN
Drug	Sulfamerazine [127-79-7]; Down 200; 15.2uM; PC3; HT_HG-U133A	AMT TRIM9 GCNT1 UTY STAT2 RYR2	8.53e-05	195	84	6	3718_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; PC3; HT_HG-U133A	MELTF TENM3 TRIM9 GCNT1 ITGA7 RYR2	8.77e-05	196	84	6	3742_DN
Drug	rapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; MCF7; HT_HG-U133A	EPHX2 AMT PHF20 IPO8 TTLL4 KDM6A	8.77e-05	196	84	6	5975_UP
Drug	Moricizine hydrochloride [31883-05-3]; Down 200; 8.6uM; PC3; HT_HG-U133A	S100A9 SRSF1 ANXA10 PAN2 GCNT2 KDM6A	8.77e-05	196	84	6	7297_DN
Drug	Isopropamide iodide [71-81-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A	MELTF AMT SRSF1 SPTBN1 ECPAS SAMD4A	8.77e-05	196	84	6	3461_UP
Drug	Triamterene [396-01-0]; Down 200; 15.8uM; MCF7; HT_HG-U133A	LINS1 AMT PHF20 FBXO42 SOWAHC UTY	9.02e-05	197	84	6	6010_DN
Drug	Lomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A	OLFML2A AMT MORN1 SPTBN1 GCNT2 TOP3A	9.02e-05	197	84	6	3620_DN
Drug	Heptaminol hydrochloride [543-15-7]; Up 200; 22uM; MCF7; HT_HG-U133A	EPHX2 S100A9 RFTN1 SPTBN1 BHMT2 KDM6A	9.02e-05	197	84	6	6015_UP
Drug	Lysergol [602-85-7]; Down 200; 15.8uM; MCF7; HT_HG-U133A	AMT TTLL4 SPTBN1 SMPD2 SOWAHC TOP3A	9.02e-05	197	84	6	4966_DN
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A	PHF20 MORN1 MAN1C1 TTLL4 SPTBN1 BFSP2	9.02e-05	197	84	6	5411_UP
Drug	Urosiol [128-13-2]; Up 200; 10.2uM; PC3; HT_HG-U133A	RABEPK SAFB IPO8 TENM3 ANXA10 TOP3A	9.28e-05	198	84	6	7243_UP
Drug	Dexamethasone acetate [1177-87-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A	RFTN1 SRSF1 AGO3 LRIG1 TOP3A SECTM1	9.28e-05	198	84	6	6271_DN
Drug	Hydrastine hydrochloride [5936-28-7]; Up 200; 9.6uM; HL60; HG-U133A	FZD4 PAFAH1B3 GCNT1 ITGA7 FAAP100 STAT2	9.28e-05	198	84	6	1740_UP
Drug	Iocetamic acid [16034-77-8]; Down 200; 6.6uM; MCF7; HT_HG-U133A	AGO3 TENM3 SPTBN1 FBXO42 URB2 GCNT2	9.28e-05	198	84	6	3361_DN
Drug	Ketoconazole [65277-42-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A	LINS1 ITPKC IPO8 TTLL4 SPTBN1 TOP3A	9.28e-05	198	84	6	2640_DN
Drug	Procaine hydrochloride [51-05-8]; Down 200; 14.6uM; HL60; HT_HG-U133A	SPG7 TTLL4 SPTBN1 ITGA7 KDM6A STAT2	9.28e-05	198	84	6	1838_DN
Drug	Serotonin hydrochloride [153-98-0]; Down 200; 18.8uM; MCF7; HT_HG-U133A	LRIG1 FBXO42 GCNT1 PTCH1 TOP3A RYR2	9.28e-05	198	84	6	3311_DN
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; MCF7; HT_HG-U133A	S100A9 AMT MORN1 MAN1C1 SPTBN1 STAT2	9.28e-05	198	84	6	3550_UP
Drug	Ethosuximide [77-67-8]; Up 200; 28.4uM; HL60; HG-U133A	ITPKC GANAB PHF20 TTLL4 FAAP100 CA6	9.54e-05	199	84	6	1433_UP
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	SRSF1 LRIG1 TTLL4 FBXO42 KDM6A TOP3A	9.54e-05	199	84	6	3403_DN
Drug	Levamisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A	S100A9 SPTBN1 GCNT1 PTCH1 FAAP100 TOP3A	9.54e-05	199	84	6	2257_DN
Drug	Mephenesin [59-47-2]; Up 200; 22uM; PC3; HT_HG-U133A	MORN1 MAN1C1 SPTBN1 ANXA10 ITGA7 RYR2	9.54e-05	199	84	6	3675_UP
Drug	Cortisone [53-06-5]; Up 200; 11uM; MCF7; HT_HG-U133A	MORN1 MAN1C1 URB2 KDM6A TOP3A SECTM1	9.54e-05	199	84	6	7416_UP
Drug	5149715; Up 200; 10uM; MCF7; HT_HG-U133A_EA	EPHX2 TENM3 ECPAS SOWAHC SAMD4A SECTM1	9.54e-05	199	84	6	890_UP
Drug	Loperamide hydrochloride [34552-83-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	MAN1C1 TTLL4 SPTBN1 SMPD2 GCNT1 RYR2	9.81e-05	200	84	6	5632_DN
Disease	Kabuki syndrome (implicated_via_orthology)	KDM6A UTY	2.34e-05	3	83	2	DOID:0060473 (implicated_via_orthology)
Disease	HIV Coinfection	SRSF1 CCR3 PTCH1 SRSF9	2.08e-04	103	83	4	C4505456
Disease	HIV Infections	SRSF1 CCR3 PTCH1 SRSF9	2.08e-04	103	83	4	C0019693
Disease	hepatocellular carcinoma (is_marker_for)	S100A9 ANXA10 BHMT2 TLR9 PTCH1 HDAC2	2.09e-04	301	83	6	DOID:684 (is_marker_for)
Disease	Cleft palate, isolated	FZD4 BHMT2 PTCH1	2.28e-04	42	83	3	C1837218
Disease	cervix uteri carcinoma in situ (is_marker_for)	SRSF1 TLR9 HDAC2	2.28e-04	42	83	3	DOID:8991 (is_marker_for)
Disease	susceptibility to mononucleosis measurement	PSORS1C1 ADCY2 RYR2	9.84e-04	69	83	3	EFO_0008403
Disease	stomach cancer (is_implicated_in)	PTCH1 KDM6A HDAC2	1.11e-03	72	83	3	DOID:10534 (is_implicated_in)
Disease	Cleft palate, cleft lip	SLC39A12 GFRAL SALL4 PTCH1 SAMD4A	1.16e-03	279	83	5	EFO_0003959, HP_0000175
Disease	sphingosine 1-phosphate measurement	FTO KDM6A	1.16e-03	18	83	2	EFO_0800185
Disease	kidney volume	FTO PTCH1	1.16e-03	18	83	2	EFO_0600044
Disease	COVID-19, mortality	TENM3 CCR3 FTO MYORG	1.37e-03	170	83	4	EFO_0004352, MONDO_0100096
Disease	Cleft Palate	FZD4 BHMT2 PTCH1	1.56e-03	81	83	3	C0008925
Disease	cardiovascular system disease (is_implicated_in)	TLR9 FTO	1.59e-03	21	83	2	DOID:1287 (is_implicated_in)
Disease	alcohol use disorder (implicated_via_orthology)	KDM6A UTY RYR2 HDAC2	2.26e-03	195	83	4	DOID:1574 (implicated_via_orthology)
Disease	cataract (is_implicated_in)	GCNT2 BFSP2	2.43e-03	26	83	2	DOID:83 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HMVVGHWENRFAKAG	URB2	846	Q14146
SLMGGCREHFENHWK	C8orf44	21	Q96CB5
HELWHAMKGVGTDEN	ANXA10	96	Q9UJ72
MNKFKDDHWALDGHV	CSMD2	3346	Q7Z408
AHGGVRFMWIKHNNL	AP1M1	51	Q9BXS5
WSGGLDHQLKMHDLN	BUB3	71	O43684
PSHGVWDMRGKQFHT	AGO3	431	Q9H9G7
DAKHWHDMELQNLGA	BFSP2	351	Q13515
IAQQMHFHWGGASSE	CA6	106	P23280
SFSDVHTMDLGKHQW	RABEPK	61	Q7Z6M1
ANWLEHMSDHFRKGG	RFTN1	316	Q14699
HDHTGLAKVWMIDFG	ITPKC	626	Q96DU7
GRWMSLHHRFVADSK	PAFAH1B3	21	Q15102
QWHSDVFSGLGSMAH	MORN1	181	Q5T089
LHAASLGMWGFHDRD	OTUD7B	196	Q6GQQ9
NALFKDAWLLHMHSG	FBXO42	306	Q6P3S6
FDLHEEMLWVGSHGG	PAN2	81	Q504Q3
HHGGSWKRMFFERHL	TCTE1	146	Q5JU00
WSKKAPMGTARFGHH	KLHL34	506	Q8N239
GKEMWDHHTHENGYN	LINS1	476	Q8NG48
TDGAFWGLSKMHVLH	LRIG1	251	Q96JA1
FGMGKMAVSWHHDEN	FTO	221	Q9C0B1
IKWSDMEDRHGGCHG	GCNT2	326	Q8N0V5
QLDHGHAAAWMDLGT	KDM6A	346	O15550
HHAMWNSRKGAAFGF	ECPAS	1091	Q5VYK3
QNFLFWHMKDHGSGE	MFSD6L	386	Q8IWD5
WHMKDHGSGELVMGF	MFSD6L	391	Q8IWD5
KHWHRGLGTAMLRDF	FAM169B	86	Q8N8A8
LLHAASLGMWGFHDR	OTUD7A	211	Q8TE49
GHHGRMLAIKASWDE	FAAP100	316	Q0VG06
TVGFHSHMKDDAQWS	KIAA1328	446	Q86T90
MIHHGDWFSGKAVGL	SMPD2	106	O60906
AGLKWGHEAIEMHSS	FZD4	331	Q9ULV1
WSHDVTLANHMEAGG	ADCY2	406	Q08462
RGHIEDCGHWTQMDK	EPHX2	516	P34913
SEKHGSWGSGLDMHT	BHMT2	316	Q9H2M3
GHNWVFGHGMCKLLS	CCR3	96	P51677
NLTTRSHHGFKGMWS	GFRAL	116	Q6UXV0
SHHGFKGMWSCLEVA	GFRAL	121	Q6UXV0
KGEEHDRWAMHFDSL	CCDC66	356	A2RUB6
AMGWEGNEVGSFHVH	CRYBA4	131	P53673
SFALMDVKRHGHPQW	ATG9B	671	Q674R7
NSWGEDHGHKGYLCM	BLMH	396	Q13867
SWHLFGMGNEIDIHS	HEPHL1	291	Q6MZM0
IAEWRGGILDHKMGH	MAN1C1	436	Q9NR34
WLKHQHDRVCGDAMF	ITGA7	606	Q13683
FGDHKARMNWVHVHN	SDR42E2	236	A6NKP2
MALSLGWKAHRNHCG	ETFBKMT	1	Q8IXQ9
FHLAHGGKMVAFAGW	AMT	41	P48728
GDLNWMLRKHHLFAN	GCNT1	386	Q02742
DMAVNWAGGLHHAKK	HDAC2	131	Q92769
MWASHALHSSGAGAD	SALL4	241	Q9UJQ4
GHFHESKGHIWKLMG	SLC39A12	436	Q504Y0
EHSHDKWSMDKLANG	RYR2	2726	Q92736
VRHHSYGRHEGAWMK	OLFML2A	406	Q68BL7
YDKEWLSRGHMHGLA	PHF20	711	Q9BVI0
WMNDTDCFLGHHDRK	IPO8	821	O15397
AGMILGWKFFDHAAH	PARL	321	Q9H300
AADPHGREHWAEMLA	SYT3	541	Q9BQG1
HGHAAAWMDLGTLYE	UTY	346	O14607
MAWKSGGASHSELIH	PCMT1	1	P22061
FHKAAQGGHMEGTLW	SEL1L3	826	Q68CR1
LTWASHEKMHEGDEG	S100A9	86	P06702
SGSWQDLKDHMREAG	SRSF9	121	Q13242
DHLKDLWNDGRIMGF	STAT2	566	P52630
EAWLGHEYLHAMKGL	MELTF	341	P08582
FHIMGRDWDDHGAGE	TMEM132C	151	Q8N3T6
MLKDAQHYGGWEHRD	GANAB	556	Q14697
GCHGLSRKYMHWQEE	PTCH1	326	Q13635
LHWAAKHGRQELLAM	SOWAHC	306	Q53LP3
VAFHESGHALVGWML	SPG7	571	Q9UQ90
SGHALVGWMLEHTEA	SPG7	576	Q9UQ90
HKRWQGGERSMSGHS	SAFB	846	Q15424
SWRDGMAFNALIHKH	SPTBN1	201	Q01082
GARDSHAGLYMWHLV	SECTM1	106	Q8WVN6
RALDFSGNALGHMWA	TLR9	601	Q9NR96
LGQKVLFRDHHMSGW	PPM1M	291	Q96MI6
WSSGLNKHFMTHQGI	ZNF75CP	331	Q92670
WHAGDLQAMISKEFH	PSORS1C1	56	Q9UIG5
ADEGSGEGHKWLMVH	USP47	1041	Q96K76
LDASNMGGWTLDKHH	TENM3	1106	Q9P273
MAEASRWHRGGASKH	PKD2L2	1	Q9NZM6
GHLLAHDFQMQFRKW	TOP3A	91	Q13472
GKHSSHEVKALGAMW	TRIM9	256	Q9C026
SGSWQDLKDHMREAG	SRSF1	131	Q07955
AGKENHFDMHRVGKW	ZNF75A	111	Q96N20
SKRNDDWLGCWGHHM	TTLL4	631	Q14679
LGHGWMSHEDLRARG	SAMD4A	266	Q9UPU9
AVEHAMFLGDAAAHW	MYORG	171	Q6NSJ0