Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

FGFR3 CLK2 CLK3 NRP1

4.11e-05145274GO:0004713
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

DGKD FGFR3 CLK2 CLK3 UHMK1 NRP1

3.07e-04709276GO:0016773
GeneOntologyMolecularFunctionkinase activity

DGKD FGFR3 CLK2 CLK3 UHMK1 NRP1

4.57e-04764276GO:0016301
GeneOntologyMolecularFunctionprotein kinase activity

FGFR3 CLK2 CLK3 UHMK1 NRP1

1.12e-03600275GO:0004672
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

DGKD FGFR3 CLK2 CLK3 UHMK1 NRP1

1.34e-03938276GO:0016772
GeneOntologyMolecularFunctionaminoacyl-tRNA ligase activity

TARS1 GARS1

1.47e-0342272GO:0004812
GeneOntologyMolecularFunctionligase activity, forming carbon-oxygen bonds

TARS1 GARS1

1.47e-0342272GO:0016875
GeneOntologyMolecularFunctionprotein serine/threonine/tyrosine kinase activity

CLK2 CLK3

1.83e-0347272GO:0004712
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

FGFR3 NRP1

3.47e-0365272GO:0004714
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

FGFR3 NRP1

5.87e-0385272GO:0019199
DomainHGTP_anticodon

TARS1 GARS1

7.20e-059272PF03129
Domainaa-tRNA-synt_IIb

TARS1 GARS1

1.10e-0411272IPR002314
DomaintRNA-synt_2b

TARS1 GARS1

1.10e-0411272PF00587
Domain-

TARS1 GARS1

1.10e-04112723.40.50.800
DomainAnticodon-bd

TARS1 GARS1

1.81e-0414272IPR004154
Domainaa-tRNA-synth_II

TARS1 GARS1

3.04e-0418272IPR006195
DomainAA_TRNA_LIGASE_II

TARS1 GARS1

3.04e-0418272PS50862
DomainWD40_repeat_dom

WDR91 WDR75 WDR33 UBR4

8.24e-04297274IPR017986
DomainCUB

TMPRSS7 NRP1

2.27e-0349272PF00431
DomainCUB

TMPRSS7 NRP1

2.36e-0350272SM00042
Domain-

TMPRSS7 NRP1

2.55e-03522722.60.120.290
DomainCUB

TMPRSS7 NRP1

2.65e-0353272PS01180
DomainCUB_dom

TMPRSS7 NRP1

3.06e-0357272IPR000859
DomainPROTEIN_KINASE_ATP

FGFR3 CLK2 CLK3 UHMK1

4.04e-03459274PS00107
DomainProt_kinase_dom

FGFR3 CLK2 CLK3 UHMK1

5.05e-03489274IPR000719
DomainPROTEIN_KINASE_DOM

FGFR3 CLK2 CLK3 UHMK1

5.20e-03493274PS50011
DomainWD40

WDR91 WDR75 WDR33

6.03e-03259273PF00400
DomainWD40

WDR91 WDR75 WDR33

6.62e-03268273SM00320
DomainWD40_repeat

WDR91 WDR75 WDR33

6.90e-03272273IPR001680
DomainKinase-like_dom

FGFR3 CLK2 CLK3 UHMK1

7.24e-03542274IPR011009
DomainWD_REPEATS_1

WDR91 WDR75 WDR33

7.33e-03278273PS00678
DomainWD_REPEATS_2

WDR91 WDR75 WDR33

7.40e-03279273PS50082
DomainWD_REPEATS_REGION

WDR91 WDR75 WDR33

7.40e-03279273PS50294
Domain-

WDR91 WDR75 WDR33

1.20e-023332732.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDR91 WDR75 WDR33

1.22e-02335273IPR015943
DomainSer/Thr_kinase_AS

CLK2 CLK3 UHMK1

1.44e-02357273IPR008271
DomainS_TKc

CLK2 CLK3 UHMK1

1.46e-02359273SM00220
DomainPROTEIN_KINASE_ST

CLK2 CLK3 UHMK1

1.50e-02362273PS00108
Pubmed

HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.

HDAC6 GARS1

7.19e-07230229415205
Pubmed

The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.

CLK2 CLK3

7.19e-0723029637771
Pubmed

Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy.

HDAC6 GARS1

7.19e-07230229520015
Pubmed

Lack of effect from genetic deletion of Hdac6 in a humanized mouse model of CMT2D.

HDAC6 GARS1

7.19e-07230238551018
Pubmed

HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia.

FGFR3 HDAC6

4.31e-06430227506979
Pubmed

Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

CLK2 CLK3

4.31e-0643027990150
Pubmed

Chromosomal mapping of three human LAMMER protein-kinase-encoding genes.

CLK2 CLK3

4.31e-0643029856501
Pubmed

Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.

CLK2 CLK3

4.31e-0643029307018
Pubmed

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

CLK2 CLK3

7.18e-06530219168442
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

XRN1 DGKD HDAC6 WDR75 TARS1 UBR4 GARS1 FERMT1

1.40e-05135330829467282
Pubmed

Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis.

GARS1 NRP1

5.58e-051330228835631
Pubmed

NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs.

XRN1 CNOT3

5.58e-051330220133598
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

SIAH2 FGFR3 WDR75 CLK2

6.86e-0525730430945288
Pubmed

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.

GARS1 NRP1

7.50e-051530226503042
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

WDR75 WDR33 UBR4 NRP1

1.47e-0431330438270169
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

FGFR3 HDAC6 CLK2 CLK3

2.45e-0435830432460013
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

WDR75 WDR33 CLK3 CNOT3

2.78e-0437030422922362
Pubmed

Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes.

HDAC6 UBR4

5.78e-044130232723828
Pubmed

High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.

XRN1 HDAC6 WDR33 GARS1

6.78e-0446930437314180
Pubmed

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

TARS1 GGCX GARS1

8.59e-0421730330619736
GeneFamilyCDC like kinases

CLK2 CLK3

8.47e-064222480
GeneFamilyAminoacyl tRNA synthetases, Class II

TARS1 GARS1

2.39e-0419222132
GeneFamilyWD repeat domain containing

WDR91 WDR75 WDR33

3.78e-03262223362
GeneFamilyT cell receptor beta locus at 7q34

TRBV6-8 TRBV6-1

4.97e-0387222372
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DGKD FERMT1

2.57e-02206222682
CoexpressionGRADE_COLON_AND_RECTAL_CANCER_UP

WDR75 TARS1 UBR4 GARS1 FERMT1

1.53e-05290295M16740
ComputationaltRNA synthesis.

TARS1 GARS1

1.89e-0415152MODULE_160
ComputationalGenes in the cancer module 133.

TARS1 GARS1

1.89e-0415152MODULE_133
ComputationalRTK signaling.

FGFR3 NRP1

1.82e-0346152MODULE_259
ComputationalGenes in the cancer module 85.

FGFR3 NRP1

2.23e-0351152MODULE_85
ComputationalNeighborhood of BUB1

TARS1 GARS1

2.32e-0352152MORF_BUB1
ComputationalNeighborhood of DEAF1

TARS1 GARS1

2.78e-0357152MORF_DEAF1
ComputationalGenes in the cancer module 199.

FGFR3 NRP1

2.78e-0357152MODULE_199
ComputationalNeighborhood of BUB1B

TARS1 GARS1

3.70e-0366152MORF_BUB1B
Diseaseurinary bladder carcinoma

FGFR3 CLK3

8.50e-0447272MONDO_0004986

Protein segments in the cluster

PeptideGeneStartEntry
DLFHYDSMNAVNWGM

ABLIM3

601

O94929
NMSHHWAGEYMSCFE

ADGRF3

301

Q8IZF5
SRLEGWMMDNNFSHH

LINC00596

11

Q86U02
HYWASPEGSMHFMRC

CCIN

161

Q13939
CVQMFDWFDYHGHMC

CLK2

226

P49760
DHENQYAQWMAACML

FERMT1

456

Q9BQL6
LCVLMSDWFNFHGHM

CLK3

366

P49761
MYEGHWLVLDNCHLM

DNHD1

4146

Q96M86
QLYQQAMEEAAWHHM

CNOT3

611

O75175
MHAFGMYNYLHCDSW

NUDCD1

56

Q96RS6
QNSAHCMTFWYHMSG

NRP1

716

O14786
SMDHFSGMHNWYACS

DGKD

156

Q16760
DQNMMNHCNLWDSHH

HDAC6

486

Q9UBN7
HDLYMIMRECWHAAP

FGFR3

721

P22607
GRHCEVHQMIGNYMW

ENPP6

81

Q6UWR7
AVYWHSSAHIMGEAM

TARS1

151

P26639
QHMENEMAHYACDCW

GARS1

431

P41250
VDWVMMQSCFGHHFM

SIAH2

216

O43255
CEWMGNMNYTAEVFH

SCFD2

141

Q8WU76
GYSWDMMVHSRSHQH

GGCX

396

P38435
WEINEHMYCGSYMDH

TMPRSS7

431

Q7RTY8
YTCLHWHHDMVMDLA

WDR75

241

Q8IWA0
ANEYHNVQSMDNMCW

XRN1

1416

Q8IZH2
QCAQDMNHNSMYWYR

TRBV6-1

41

A0A0K0K1D8
QCAQDMNHGYMSWYR

TRBV6-8

41

A0A0A6YYG3
RMMHECYQIWAQLEH

PIPOX

66

Q9P0Z9
HNDMWMLTADHGGYV

WDR33

171

Q9C0J8
FMNQHWYHCHTCKMV

UBR4

1671

Q5T4S7
MQQHECAMSWRAHYG

WDR91

591

A4D1P6
SHQGCSMWMIQHCAR

UHMK1

126

Q8TAS1