Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	neurotrophin p75 receptor binding	ZNF274 NTRK1	1.27e-04	5	72	2	GO:0005166
GeneOntologyMolecularFunction	neurotrophin receptor activity	NTRK1 NTRK3	1.27e-04	5	72	2	GO:0005030
GeneOntologyMolecularFunction	GPI-linked ephrin receptor activity	NTRK1 NTRK3	2.66e-04	7	72	2	GO:0005004
GeneOntologyBiologicalProcess	positive regulation of synaptic transmission, glutamatergic	RAB3GAP1 NTRK1 SHANK3 CCKBR	1.28e-05	43	69	4	GO:0051968
GeneOntologyBiologicalProcess	regulation of synaptic transmission, glutamatergic	RAB3GAP1 NTRK1 GRIK2 SHANK3 CCKBR	1.42e-05	92	69	5	GO:0051966
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RANBP2 SLF2	5.41e-05	21	74	3	GO:0106068
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RANBP2	3.41e-04	8	74	2	GO:1990723
Domain	SCAN	ZNF18 ZNF274 ZNF174 ZSCAN26 ZNF75D	2.42e-06	56	72	5	SM00431
Domain	SCAN_BOX	ZNF18 ZNF274 ZNF174 ZSCAN26 ZNF75D	2.89e-06	58	72	5	PS50804
Domain	SCAN	ZNF18 ZNF274 ZNF174 ZSCAN26 ZNF75D	2.89e-06	58	72	5	PF02023
Domain	SCAN_dom	ZNF18 ZNF274 ZNF174 ZSCAN26 ZNF75D	2.89e-06	58	72	5	IPR003309
Domain	Retrov_capsid_C	ZNF18 ZNF274 ZNF174 ZSCAN26 ZNF75D	3.15e-06	59	72	5	IPR008916
Domain	TPKR_C2	NTRK1 NTRK3	4.39e-05	3	72	2	PF16920
Domain	Tyr_kinase_NGF_rcpt	NTRK1 NTRK3	4.39e-05	3	72	2	IPR020777
Domain	NTRK_C2	NTRK1 NTRK3	4.39e-05	3	72	2	IPR031635
Domain	PrprotnconvertsP	PCSK7 PCSK4	3.04e-04	7	72	2	IPR002884
Domain	P_proprotein	PCSK7 PCSK4	3.04e-04	7	72	2	PF01483
Domain	S8_pro-domain	PCSK7 PCSK4	3.04e-04	7	72	2	IPR032815
Domain	-	PCSK7 PCSK4	3.04e-04	7	72	2	3.30.70.850
Domain	S8_pro-domain	PCSK7 PCSK4	3.04e-04	7	72	2	PF16470
Domain	DHC_N1	DNAH5 DNAH8	4.04e-04	8	72	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH5 DNAH8	4.04e-04	8	72	2	IPR013594
Domain	Peptidase_S8_His-AS	PCSK7 PCSK4	5.18e-04	9	72	2	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK7 PCSK4	5.18e-04	9	72	2	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK7 PCSK4	6.46e-04	10	72	2	IPR015500
Domain	SUBTILASE_ASP	PCSK7 PCSK4	6.46e-04	10	72	2	PS00136
Domain	SUBTILASE_HIS	PCSK7 PCSK4	6.46e-04	10	72	2	PS00137
Domain	SUBTILASE_SER	PCSK7 PCSK4	6.46e-04	10	72	2	PS00138
Domain	-	RGPD4 RANBP2 SBF2 MCF2L2 MTMR3 OSBPL11 PLEKHM1	7.64e-04	391	72	7	2.30.29.30
Domain	-	PCSK7 PCSK4	7.88e-04	11	72	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK7 PCSK4	7.88e-04	11	72	2	IPR000209
Domain	Peptidase_S8	PCSK7 PCSK4	7.88e-04	11	72	2	PF00082
Domain	Tyr_kinase_rcpt_2_CS	NTRK1 NTRK3	7.88e-04	11	72	2	IPR002011
Domain	Ran_BP1	RGPD4 RANBP2	9.43e-04	12	72	2	PF00638
Domain	RECEPTOR_TYR_KIN_II	NTRK1 NTRK3	9.43e-04	12	72	2	PS00239
Domain	RANBD1	RGPD4 RANBP2	9.43e-04	12	72	2	PS50196
Domain	DUF4599	SPATA31A7 SPATA31A5	9.43e-04	12	72	2	PF15371
Domain	DUF4599	SPATA31A7 SPATA31A5	9.43e-04	12	72	2	IPR027970
Domain	RanBD	RGPD4 RANBP2	1.11e-03	13	72	2	SM00160
Domain	Ran_bind_dom	RGPD4 RANBP2	1.11e-03	13	72	2	IPR000156
Domain	PH_dom-like	RGPD4 RANBP2 SBF2 MCF2L2 MTMR3 OSBPL11 PLEKHM1	1.26e-03	426	72	7	IPR011993
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH8	1.29e-03	14	72	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH8	1.29e-03	14	72	2	IPR024743
Domain	Myotubularin-like_Pase_dom	SBF2 MTMR3	1.29e-03	14	72	2	IPR010569
Domain	Dynein_heavy_dom-2	DNAH5 DNAH8	1.29e-03	14	72	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH8	1.29e-03	14	72	2	PF08393
Domain	MT	DNAH5 DNAH8	1.29e-03	14	72	2	PF12777
Domain	AAA_8	DNAH5 DNAH8	1.29e-03	14	72	2	PF12780
Domain	PPASE_MYOTUBULARIN	SBF2 MTMR3	1.29e-03	14	72	2	PS51339
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH8	1.29e-03	14	72	2	IPR011704
Domain	Myotubularin_fam	SBF2 MTMR3	1.29e-03	14	72	2	IPR030564
Domain	Myotub-related	SBF2 MTMR3	1.29e-03	14	72	2	PF06602
Domain	AAA_5	DNAH5 DNAH8	1.29e-03	14	72	2	PF07728
Domain	DHC_fam	DNAH5 DNAH8	1.49e-03	15	72	2	IPR026983
Domain	Dynein_heavy_dom	DNAH5 DNAH8	1.49e-03	15	72	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH8	1.49e-03	15	72	2	PF03028
Domain	Propept_inh	PCSK7 PCSK4	1.92e-03	17	72	2	IPR009020
Domain	-	PCSK7 CUL7 PCSK4	2.82e-03	73	72	3	2.60.120.260
Domain	Growth_fac_rcpt_	EYS SUSD1 CUBN PCSK4	3.10e-03	156	72	4	IPR009030
Domain	C2H2_Znf_fam	ZNF18 ZNF174	3.83e-03	24	72	2	IPR027775
Pubmed	Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage.	NTRK1 NTRK3 EZH2	4.48e-06	15	76	3	38167468
Pubmed	Infantile NTRK-associated Mesenchymal Tumors.	NTRK1 NTRK3	4.71e-06	2	76	2	28683589
Pubmed	S100 and Pan-Trk Staining to Report NTRK Fusion-Positive Uterine Sarcoma: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual Meeting.	NTRK1 NTRK3	4.71e-06	2	76	2	33290352
Pubmed	Cytomorphologic features of NTRK-rearranged thyroid carcinoma.	NTRK1 NTRK3	4.71e-06	2	76	2	33074583
Pubmed	Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.	NTRK1 NTRK3	4.71e-06	2	76	2	24603864
Pubmed	Nanoformulation of EPZ011989 Attenuates EZH2-c-Myb Epigenetic Interaction by Proteasomal Degradation in Acute Myeloid Leukemia.	EZH2 MYB	4.71e-06	2	76	2	31904978
Pubmed	PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.	PCSK7 APOB	4.71e-06	2	76	2	37967646
Pubmed	Identification of NTRK fusions in pediatric mesenchymal tumors.	NTRK1 NTRK3	4.71e-06	2	76	2	28097808
Pubmed	Fine-needle aspiration cytomorphology of papillary thyroid carcinoma with NTRK gene rearrangement from a case series with predominantly indeterminate cytology.	NTRK1 NTRK3	4.71e-06	2	76	2	32931153
Pubmed	Detection of NTRK1/3 Rearrangements in Papillary Thyroid Carcinoma Using Immunohistochemistry, Fluorescent In Situ Hybridization, and Next-Generation Sequencing.	NTRK1 NTRK3	4.71e-06	2	76	2	32880785
Pubmed	NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma.	NTRK1 NTRK3	4.71e-06	2	76	2	29553955
Pubmed	Testis developmental phenotypes in neurotropin receptor trkA and trkC null mutations: role in formation of seminiferous cords and germ cell survival.	NTRK1 NTRK3	4.71e-06	2	76	2	12021070
Pubmed	EZH2 regulates neuroblastoma cell differentiation via NTRK1 promoter epigenetic modifications.	NTRK1 EZH2	4.71e-06	2	76	2	29507419
Pubmed	Survival of inner ear sensory neurons in trk mutant mice.	NTRK1 NTRK3	1.41e-05	3	76	2	9232598
Pubmed	Gangliosides activate Trk receptors by inducing the release of neurotrophins.	NTRK1 NTRK3	1.41e-05	3	76	2	12388556
Pubmed	Dual innervation of neonatal Merkel cells in mouse touch domes.	NTRK1 NTRK3	1.41e-05	3	76	2	24637732
Pubmed	Dimerization of the Trk receptors in the plasma membrane: effects of their cognate ligands.	NTRK1 NTRK3	1.41e-05	3	76	2	30366959
Pubmed	TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations.	NTRK1 NTRK3	1.41e-05	3	76	2	31871300
Pubmed	The Effects of IGF-1 on Trk Expressing DRG Neurons with HIV-gp120- Induced Neurotoxicity.	NTRK1 NTRK3	1.41e-05	3	76	2	26652865
Pubmed	Deciphering autism heterogeneity: a molecular stratification approach in four mouse models.	SHANK3 OPRM1	1.41e-05	3	76	2	39366951
Pubmed	Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC.	NTRK1 NTRK3	1.41e-05	3	76	2	10674466
Pubmed	The development of myelinated nociceptors is dependent upon trks in the trigeminal ganglion.	NTRK1 NTRK3	1.41e-05	3	76	2	15530548
Pubmed	Gene expression of TRK neurotrophin receptors in advanced neuroblastomas in Singapore--a pilot study.	NTRK1 NTRK3	1.41e-05	3	76	2	21728718
Pubmed	Neurotrophin actions during the development of the peripheral nervous system.	NTRK1 NTRK3	1.41e-05	3	76	2	10383116
Pubmed	Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions.	NTRK1 NTRK3	1.41e-05	3	76	2	28719467
Pubmed	Developmental dependency of Merkel endings on trks in the palate.	NTRK1 NTRK3	1.41e-05	3	76	2	11295244
Pubmed	DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma.	NTRK1 NTRK3	1.41e-05	3	76	2	21295543
Pubmed	TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons.	NTRK1 NTRK3	1.41e-05	3	76	2	8918886
Pubmed	Trk receptor expression and inhibition in neuroblastomas.	NTRK1 NTRK3	1.41e-05	3	76	2	19417027
Pubmed	Prognostic value of tropomyosin-related kinases A, B, and C in gastric cancer.	NTRK1 NTRK3	1.41e-05	3	76	2	26459250
Pubmed	A chemical-genetic approach to studying neurotrophin signaling.	NTRK1 NTRK3	1.41e-05	3	76	2	15820690
Pubmed	The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas.	NTRK1 NTRK3	1.41e-05	3	76	2	16862449
Pubmed	Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.	NTRK1 NTRK3	1.41e-05	3	76	2	7823156
Pubmed	Crystal Structures of Neurotrophin Receptors Kinase Domain.	NTRK1 NTRK3	1.41e-05	3	76	2	28215291
Pubmed	Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons.	NTRK1 NTRK3	1.41e-05	3	76	2	8575307
Pubmed	ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research.	NTRK1 NTRK3	1.41e-05	3	76	2	31268127
Pubmed	NTRK fusion analysis reveals enrichment in Middle Eastern BRAF wild-type PTC.	NTRK1 NTRK3	1.41e-05	3	76	2	33524004
Pubmed	The trk family of tyrosine protein kinase receptors.	NTRK1 NTRK3	1.41e-05	3	76	2	1751544
Pubmed	An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells.	NTRK1 NTRK3	2.82e-05	4	76	2	14706643
Pubmed	Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos.	NTRK1 NTRK3	2.82e-05	4	76	2	9214629
Pubmed	Neurotrophin receptors: a window into neuronal differentiation.	NTRK1 NTRK3	2.82e-05	4	76	2	1327010
Pubmed	Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR.	NTRK1 NTRK3	2.82e-05	4	76	2	9927421
Pubmed	Dependence receptors: the trophic theory revisited.	NTRK1 NTRK3	2.82e-05	4	76	2	21139137
Pubmed	Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling.	NTRK1 NTRK3	2.82e-05	4	76	2	12471037
Pubmed	p75 and TrkC neurotrophin receptors demonstrate a different immunoreactivity profile in comparison to TrkA and TrkB receptors in human normal pituitary gland and adenomas.	NTRK1 NTRK3	2.82e-05	4	76	2	18319596
Pubmed	Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons.	NTRK1 NTRK3	2.82e-05	4	76	2	12532410
Pubmed	Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC.	NTRK1 NTRK3	2.82e-05	4	76	2	8621424
Pubmed	TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.	NTRK1 NTRK3	2.82e-05	4	76	2	8815902
Pubmed	N-acetylserotonin activates TrkB receptor in a circadian rhythm.	NTRK1 NTRK3	2.82e-05	4	76	2	20133677
Pubmed	Ubiquitin Regulation of Trk Receptor Trafficking and Degradation.	NTRK1 NTRK3	2.82e-05	4	76	2	29911254
Pubmed	ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.	OSBPL11 APOB	2.82e-05	4	76	2	22906437
Pubmed	The dependence receptor TrkC regulates the number of sensory neurons during DRG development.	NTRK1 NTRK3	2.82e-05	4	76	2	30071216
Pubmed	Differential expression of neurotrophin receptors during renal development.	NTRK1 NTRK3	2.82e-05	4	76	2	8306895
Pubmed	Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.	NTRK1 NTRK3	2.82e-05	4	76	2	7991545
Pubmed	Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.	NTRK1 NTRK3	2.82e-05	4	76	2	20811452
Pubmed	Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.	NTRK1 NTRK3	2.82e-05	4	76	2	16037097
Pubmed	Neurotrophin receptors expression and JNK pathway activation in human astrocytomas.	NTRK1 NTRK3	2.82e-05	4	76	2	17971243
Pubmed	TrkA mediates retrograde semaphorin 3A signaling through plexin A4 to regulate dendritic branching.	NTRK1 NTRK3	2.82e-05	4	76	2	26945060
Pubmed	Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia.	NTRK1 NTRK3	2.82e-05	4	76	2	8764654
Pubmed	Sensory integration in mouse insular cortex reflects GABA circuit maturation.	SHANK3 ITPR3	2.82e-05	4	76	2	25088363
Pubmed	A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching.	NTRK1 NTRK3	2.82e-05	4	76	2	23598414
Pubmed	The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes.	ZNF75D ZNF75CP	2.82e-05	4	76	2	8661144
Pubmed	Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.	NTRK1 NTRK3	4.69e-05	5	76	2	15247919
Pubmed	Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling.	NTRK1 NTRK3	4.69e-05	5	76	2	8898237
Pubmed	Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.	NTRK1 NTRK3	4.69e-05	5	76	2	21102451
Pubmed	A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein.	NTRK1 NTRK3	4.69e-05	5	76	2	15167895
Pubmed	Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA.	NTRK1 NTRK3	4.69e-05	5	76	2	15513915
Pubmed	Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC.	NTRK1 NTRK3	4.69e-05	5	76	2	10207144
Pubmed	Aberrant lipid accumulation in the mouse visceral yolk sac resulting from maternal diabetes and obesity.	APOB CUBN	4.69e-05	5	76	2	36936697
Pubmed	Expression of neurotrophin receptors by retinoinvasive uveal melanoma.	NTRK1 NTRK3	4.69e-05	5	76	2	22343487
Pubmed	Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis.	CSF2RA EZH2	4.69e-05	5	76	2	34533976
Pubmed	NCAPD3 promotes prostate cancer progression by up-regulating EZH2 and MALAT1 through STAT3 and E2F1.	NCAPD3 EZH2	4.69e-05	5	76	2	35085770
Pubmed	Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development.	NTRK1 NTRK3	4.69e-05	5	76	2	23701859
Pubmed	The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death.	NTRK1 NTRK3	4.69e-05	5	76	2	9472042
Pubmed	Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.	NTRK1 NTRK3 NKX2-2	4.75e-05	32	76	3	26758845
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A7 SPATA31A5	7.03e-05	6	76	2	20850414
Pubmed	Neurotrophins and neurotransmitters in human palatine tonsils: an immunohistochemical and RT-PCR analysis.	NTRK1 NTRK3	7.03e-05	6	76	2	16786155
Pubmed	Neph1 is required for neurite branching and is negatively regulated by the PRRXL1 homeodomain factor in the developing spinal cord dorsal horn.	NTRK1 NTRK3	7.03e-05	6	76	2	39049046
Pubmed	Neurotrophins are not required for normal embryonic development of olfactory neurons.	NTRK1 NTRK3	7.03e-05	6	76	2	11356021
Pubmed	IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life.	NTRK1 NTRK3	7.03e-05	6	76	2	9354331
Pubmed	Selective regulation of nerve growth factor expression in developing cutaneous tissue by early sensory innervation.	NTRK1 NTRK3	7.03e-05	6	76	2	21529369
Pubmed	Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis.	NTRK1 NTRK3	7.03e-05	6	76	2	23869086
Pubmed	Expression of neurotrophins and their receptors in peripheral lung cells of mice.	NTRK1 NTRK3	7.03e-05	6	76	2	12122447
Pubmed	Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System.	NTRK1 NTRK3	7.03e-05	6	76	2	28360836
Pubmed	Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC.	NTRK1 NTRK3	7.03e-05	6	76	2	12117822
Pubmed	POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression.	NTRK1 NTRK3	7.03e-05	6	76	2	10357931
Pubmed	A chemoattractant role for NT-3 in proprioceptive axon guidance.	NTRK1 NTRK3	7.03e-05	6	76	2	15550985
Pubmed	PtdIns5P regulation through evolution: roles in membrane trafficking?	SBF2 MTMR3	7.03e-05	6	76	2	18774718
Pubmed	Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS.	NTRK1 NTRK3	7.03e-05	6	76	2	15322547
Pubmed	Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice.	NTRK1 NTRK3	7.03e-05	6	76	2	9364058
Pubmed	Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo.	NTRK1 NTRK3	7.03e-05	6	76	2	9728914
Pubmed	ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.	NTRK1 NTRK3	7.03e-05	6	76	2	12006576
Pubmed	Control of patterns of corneal innervation by Pax6.	NTRK1 NTRK3	7.03e-05	6	76	2	19029029
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A7 SPATA31A5	7.03e-05	6	76	2	25930072
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RANBP2	9.83e-05	7	76	2	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RANBP2	9.83e-05	7	76	2	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RANBP2	9.83e-05	7	76	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RANBP2	9.83e-05	7	76	2	9037092
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RANBP2	9.83e-05	7	76	2	8603673
Pubmed	MafA transcription factor identifies the early ret-expressing sensory neurons.	NTRK1 NTRK3	9.83e-05	7	76	2	20213756
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	7.52e-05	8	76	2	chr9q12
Cytoband	2q12.3	RGPD4 RANBP2	3.62e-04	17	76	2	2q12.3
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK7 PCSK4	2.77e-04	9	51	2	973
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	SBF2 MTMR3	8.00e-04	15	51	2	903
GeneFamily	Dyneins, axonemal	DNAH5 DNAH8	1.03e-03	17	51	2	536
ToppCell	remission-HSPC\|World / disease stage, cell group and cell class	C9orf43 ZNF174 NTRK1 PTGDR2 MYB	9.62e-06	166	76	5	d269ee6f7adb55b05dcb5eaea96629ccb0b2d6e3
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 B3GNT4 CACNA1S CCKBR MYB	1.18e-05	173	76	5	a7cc63bb3ab41feb9e4072700d44dbbbc62c47c6
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 B3GNT4 CACNA1S CCKBR MYB	1.18e-05	173	76	5	e3e3a67a5a93ef4475224a256d45ae24526383cc
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NCAPD3 C9orf43 POLA1 ZGRF1 EZH2	1.21e-05	174	76	5	c988471207ba06195bc3e41056435e8c31c20bbe
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NCAPD3 POLA1 ZGRF1 EZH2 MYB	1.42e-05	180	76	5	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	COPD-Myeloid\|COPD / Disease state, Lineage and Cell class	DPYD CSF2RA CD163L1 SBF2 MCF2L2	1.99e-05	193	76	5	f58552e286aa27e592497ad78776f58f8ee09841
ToppCell	IPF-Myeloid\|IPF / Disease state, Lineage and Cell class	DPYD CSF2RA CD163L1 SBF2 MCF2L2	2.09e-05	195	76	5	fdeb958aeaa00f3fc25c4e59efbbc6f4a572c9ce
ToppCell	Control-Myeloid\|Control / Disease state, Lineage and Cell class	DPYD CSF2RA CD163L1 SBF2 MCF2L2	2.09e-05	195	76	5	46ce2e403ca5d757e5ba17349b6c7ce5cde1f195
ToppCell	Sigmoid-T_cell-Treg\|T_cell / Region, Cell class and subclass	CARD16 LINC02694 DNAH8 MYB OPRM1	2.25e-05	198	76	5	e2d2f9f209f77d0c48cfe3e9902c0ae0795511b2
Drug	AC1MHMZ2	RANBP2 NTRK3 PCSK7 PCSK4	6.95e-06	39	72	4	CID003007770
Drug	AC1NAX4S	PCSK7 PCSK4	9.86e-06	2	72	2	CID004459028
Drug	NVP-AUY922	NTRK1 NTRK3	9.86e-06	2	72	2	CID010096043
Disease	Manic	NTRK1 GRIK2 DNAH8 SHANK3	3.84e-05	78	71	4	C0338831
Disease	primary dental caries	SUSD1 CUBN SLC22A24	7.57e-05	34	71	3	EFO_0600095
Disease	cardiac hypertrophy	MKRN2 GRIK2 LINC02694	8.27e-05	35	71	3	EFO_0002503
Disease	pancreatic cancer (biomarker_via_orthology)	EZH2 CCKBR	1.19e-04	7	71	2	DOID:1793 (biomarker_via_orthology)
Disease	Schizophrenia	DPYD CSF2RA NTRK1 NTRK3 GRIK2 AKR1A1 LHX6 SHANK3 OPRM1	2.61e-04	883	71	9	C0036341
Disease	Semantic-Pragmatic Disorder	DPYD SHANK3	3.10e-04	11	71	2	C0454655
Disease	Auditory Processing Disorder, Central	DPYD SHANK3	3.10e-04	11	71	2	C0751257
Disease	Language Delay	DPYD SHANK3	3.10e-04	11	71	2	C0023012
Disease	Language Development Disorders	DPYD SHANK3	3.10e-04	11	71	2	C0023014
Disease	Speech Delay	DPYD SHANK3	3.10e-04	11	71	2	C0241210
Disease	Respiratory Depression	CACNA1S OPRM1	4.38e-04	13	71	2	C0235063
Disease	Respiratory Insufficiency	CACNA1S OPRM1	4.38e-04	13	71	2	C0035229
Disease	Respiratory Failure	CACNA1S OPRM1	4.38e-04	13	71	2	C1145670
Disease	Malignant Glioma	NTRK1 NTRK3 MYB	6.51e-04	70	71	3	C0555198
Disease	mixed gliomas	NTRK1 NTRK3 MYB	6.51e-04	70	71	3	C0259783
Disease	Neuralgia, Supraorbital	NTRK1 OPRM1	6.70e-04	16	71	2	C0038870
Disease	Neuralgia, Iliohypogastric Nerve	NTRK1 OPRM1	6.70e-04	16	71	2	C0423712
Disease	Neuralgia, Perineal	NTRK1 OPRM1	6.70e-04	16	71	2	C0423711
Disease	Neuralgia	NTRK1 OPRM1	6.70e-04	16	71	2	C0027796
Disease	Neuralgia, Atypical	NTRK1 OPRM1	6.70e-04	16	71	2	C0234247
Disease	Neuralgia, Stump	NTRK1 OPRM1	6.70e-04	16	71	2	C0234249
Disease	Paroxysmal Nerve Pain	NTRK1 OPRM1	6.70e-04	16	71	2	C0751373
Disease	Nerve Pain	NTRK1 OPRM1	6.70e-04	16	71	2	C0751372
Disease	Neuralgia, Ilioinguinal	NTRK1 OPRM1	6.70e-04	16	71	2	C0751371
Disease	Neuralgia, Vidian	NTRK1 OPRM1	6.70e-04	16	71	2	C0042656
Disease	Asthma	DNAH5 PTGDR2 MYB	9.60e-04	80	71	3	C0004096
Disease	liver fibrosis measurement	APOB MYB ITPR3	1.18e-03	86	71	3	EFO_0010576
Disease	Glioma	NTRK1 NTRK3 MYB	1.22e-03	87	71	3	C0017638
Disease	colorectal health	PCNX2 EYS NTRK3 GRIK2	1.42e-03	201	71	4	EFO_0008460
Disease	peptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease	DPYD CCKBR	1.52e-03	24	71	2	EFO_0003948, EFO_0009923, MONDO_0004247
Disease	gastroesophageal reflux disease	DPYD APOB CCKBR	1.88e-03	101	71	3	EFO_0003948
Disease	diffuse plaque measurement	EYS NTRK3 GRIK2 CUL7 LHX6 MYB OPRM1	2.30e-03	758	71	7	EFO_0010699

Protein segments in the cluster

Peptide	Gene	Start	Entry
VRNICRWVRQAVQIP	DPYD	691	Q12882
TWCRVQKQKHLPLRV	CD163L1	1381	Q9NR16
ICRPLQARVWQTRSH	CCKBR	156	P32239
QQHRRWRLHCLKLQP	MTHFD1L	341	Q6UB35
WNRQCTFILRQILPK	CC2D2B	1336	Q6DHV5
KIQCWFRHRRNQDKP	CERS5	121	Q8N5B7
IRQWRCAKQFENPII	MKRN2	271	Q9H000
RREQVLKVCANHWIT	RANBP2	2076	P49792
CQVPLFVQIHHKWRR	RAB3GAP1	161	Q15042
TRLLECPWLQQQHKG	ITPR3	1506	Q14573
RCPTLQHIWKVNQEG	PARP3	351	Q9Y6F1
KPQQVCWQRRLQGLQ	MBD3L1	61	Q8WWY6
RGCWQREPQQRHSIK	NTRK1	761	P04629
RTPRNAKIINVCNWI	OPRM1	181	P35372
GKTCRRQLVEEWHPQ	EYS	21	Q5T1H1
QLQEPITGWRKTVCH	LPCAT4	76	Q643R3
CWQREPQQRLNIKEI	NTRK3	806	Q16288
RHNRLPVVCWKNSRS	SBF2	1176	Q86WG5
HKNLPRARAIWQECQ	MCF2L2	716	Q86YR7
LNQEWKQRRIQPVHI	EZH2	56	Q15910
LEWIQHCARKRQEPS	PCNX2	1601	A6NKB5
WLPTQPQRKCAVRVQ	PCSK4	446	Q6UW60
QVRPCLTWRDVQHII	PCSK7	421	Q16549
FWPIIQIRIKRCQQG	CUL7	941	Q14999
VAHWGQQQIRPIKSV	DNAH8	921	Q96JB1
RVIQVWFQNCRARHK	LHX6	261	Q9UPM6
NQSWRKERILNVPLC	FOLR3	121	P41439
VTWCNQLRHPSCRLQ	NLRP4	656	Q96MN2
PNRTDVQCQHRWQKV	MYB	71	P10242
VQCQHRWQKVLNPEL	MYB	76	P10242
LQVVRPVWAQNHRTV	PTGDR2	131	Q9Y5Y4
VLLQRINVCKAPHWS	POLA1	646	P09884
TCRWTIHQPQSQVIL	CUBN	841	O60494
CNLVFQVQGRKRWHL	HSPBAP1	181	Q96EW2
HQRIQISLWPRKQKR	FAM157B	91	P0CG42
GQPQCSTHILQWLKR	APOB	386	P04114
KELHLQRWVVAACPQ	B3GNT4	196	Q9C0J1
TRPRLQKVASWQAHQ	DPH7	181	Q9BTV6
NKIRVLCHRIVNATW	CACNA1S	786	Q13698
LAVCQHPQCWATIRR	C9orf43	16	Q8TAL5
HNIVQNRSKIRRVLW	ASIC5	51	Q9NY37
WRRQISELHPICNKS	FSHR	281	P23945
LFAIVRQWVPQVQHK	CLIP3	81	Q96DZ5
ICNALGVPHIQTRWK	GRIK2	121	Q13002
PITVHNICRWNQKIR	CFAP47	61	Q6ZTR5
QRIWKQKLQRCHVQN	CARD16	121	Q5EG05
VRCNTTHCLVRWKQP	CSF2RA	226	P15509
KILWARQLFHRIQQP	DNAH5	626	Q8TE73
RNLSEVPQCVWRINV	LRRC40	46	Q9H9A6
QCQEWLKRLNNAIRP	MTMR3	106	Q13615
KERQHWVSRLQICTQ	OSBPL11	141	Q9BXB4
QPTKICEQHVRWGRF	GARIN3	91	Q8TC56
IIHNWDLTKRPICRQ	PLEKHM1	871	Q9Y4G2
KQLVEQQPIHTCRFW	RSPH6A	331	Q9H0K4
RREQVLKVCANHWIT	RGPD4	1101	Q7Z3J3
QKCQRFIHPQWQLLH	SLC22A24	86	Q8N4F4
GCQWRLVAPLNHIIQ	OVCH1	1006	Q7RTY7
IPVCVRRSWLAVNQA	SPATA31A7	746	Q8IWB4
RLTPTQVKIWFQNHR	NKX2-2	166	O95096
RIHGKWQEIIQNCRP	SLF2	1146	Q8IX21
RWQVQRKVICIPKSI	AKR1A1	251	P14550
PRCVQIQKAWLRGVV	NCAPD3	611	P42695
KLIQAPAHVFRQCWV	LINC02694	86	Q8NAA6
QLRQLCRQWLQPELH	ZNF174	66	Q15697
IPVCVRRSWLAVNQA	SPATA31A5	746	Q5VU36
PVWAAKQRVLCALNH	SHANK3	31	Q9BYB0
NPWNIMIKHRQVQRR	DNTTIP1	36	Q9H147
CVRWQINSRRINPKI	SUSD1	311	Q6UWL2
AINQLQKLCHQWLRP	ZNF75CP	66	Q92670
QLRELCHQWLQPKAR	ZNF274	181	Q96GC6
CHQWLQPKARSKEQI	ZNF274	186	Q96GC6
RLRELCQQWLQPETH	ZSCAN26	71	Q16670
TISQLQKLCHQWLRP	ZNF75D	66	P51815
ACLRKNQLWGRVIQH	ZGRF1	2041	Q86YA3
QLRKLCFQWLQPEVH	ZNF18	61	P17022
WTQHPLIQKNRRVVL	TMEM134	111	Q9H6X4
IQQERPLCHKGRDWQ	RPTN	666	Q6XPR3
WHAVNQQPIPTRVCK	MYOM3	746	Q5VTT5