Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXND1 PLXNB1 NRP2

1.71e-0512873GO:0017154
GeneOntologyMolecularFunctionmicrotubule motor activity

DNHD1 KIF1A STARD9 KIF18B

2.48e-0470874GO:0003777
GeneOntologyMolecularFunctionprotein kinase activity

AMHR2 CAD TRIB3 COQ8B MAP3K10 PKN2 PLK1 TESK1 NRP2 SBK3

2.79e-046008710GO:0004672
GeneOntologyMolecularFunctiontubulin binding

MAP1A KIF1A ARHGEF7 STARD9 DLEC1 KIF18B PLK1 CCDC88B

5.56e-04428878GO:0015631
GeneOntologyCellularComponentsemaphorin receptor complex

PLXND1 PLXNB1 NRP2

2.21e-0513913GO:0002116
MousePhenoabnormal snout morphology

HIC1 MEGF8 OSTM1 DVL3 OS9 PLXND1 EXOC3L2 NIPBL AHDC1

5.10e-06257709MP:0000443
MousePhenoshort snout

HIC1 MEGF8 OSTM1 DVL3 PLXND1 AHDC1

5.97e-05136706MP:0000445
MousePhenosmall snout

HIC1 MEGF8 OSTM1 DVL3 PLXND1 AHDC1

8.21e-05144706MP:0030190
DomainSH3_2

MYO15B ARHGEF7 MAP3K10 BAIAP2L2 ARHGEF6

5.34e-0586885IPR011511
DomainSH3_2

MYO15B ARHGEF7 MAP3K10 BAIAP2L2 ARHGEF6

5.34e-0586885PF07653
DomainFAM47

FAM47C FAM47B

1.31e-044882PF14642
DomainFAM47

FAM47C FAM47B

1.31e-044882IPR032743
DomainPH_DOMAIN

IRS4 KIF1A PHLDA1 ARHGEF7 DOK3 ARHGEF6 PHLPP2

3.48e-04279887PS50003
DomainPSI

MEGF8 PLXND1 PLXNB1

4.54e-0432883PF01437
DomainPlexin_repeat

MEGF8 PLXND1 PLXNB1

4.54e-0432883IPR002165
DomainPlexin_cytopl

PLXND1 PLXNB1

7.73e-049882PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXND1 PLXNB1

7.73e-049882IPR013548
DomainPlexin

PLXND1 PLXNB1

7.73e-049882IPR031148
DomainKinesin_motor_CS

KIF1A STARD9 KIF18B

9.47e-0441883IPR019821
DomainVDCCAlpha1

CACNA1S CACNA1H

9.64e-0410882IPR002077
DomainKINESIN_MOTOR_1

KIF1A STARD9 KIF18B

1.16e-0344883PS00411
Domain-

KIF1A STARD9 KIF18B

1.16e-03448833.40.850.10
DomainKinesin_motor_dom

KIF1A STARD9 KIF18B

1.16e-0344883IPR001752
DomainKinesin

KIF1A STARD9 KIF18B

1.16e-0344883PF00225
DomainKINESIN_MOTOR_2

KIF1A STARD9 KIF18B

1.16e-0344883PS50067
DomainPSI

MEGF8 PLXND1 PLXNB1

1.16e-0344883IPR016201
DomainKISc

KIF1A STARD9 KIF18B

1.16e-0344883SM00129
DomainPTBI

IRS4 DOK3

1.17e-0311882SM00310
DomainPSI

MEGF8 PLXND1 PLXNB1

1.33e-0346883SM00423
DomainIRS_PTB

IRS4 DOK3

1.40e-0312882PS51064
DomainSMAD_FHA_domain

KIF1A STARD9 IRF8

1.89e-0352883IPR008984
DomainIRS_PTB

IRS4 DOK3

1.93e-0314882IPR002404
DomainIRS

IRS4 DOK3

1.93e-0314882PF02174
DomainPH

IRS4 KIF1A PHLDA1 ARHGEF7 DOK3 ARHGEF6

2.01e-03278886SM00233
DomainIon_trans_dom

CACNA1S KCNH2 CACNA1H MCOLN1

2.07e-03114884IPR005821
DomainIon_trans

CACNA1S KCNH2 CACNA1H MCOLN1

2.07e-03114884PF00520
DomainPH_domain

IRS4 KIF1A PHLDA1 ARHGEF7 DOK3 ARHGEF6

2.09e-03280886IPR001849
DomainPkinase

AMHR2 TRIB3 MAP3K10 PKN2 PLK1 TESK1 SBK3

2.14e-03381887PF00069
DomainPROTEIN_KINASE_DOM

AMHR2 TRIB3 COQ8B MAP3K10 PKN2 PLK1 TESK1 SBK3

2.26e-03493888PS50011
Domain-

IRS4 KIF1A PHLDA1 ARHGEF7 DOK3 ARHGEF6 PHLPP2

2.48e-033918872.30.29.30
DomainPost-SET_dom

EHMT2 NSD1

2.52e-0316882IPR003616
DomainPostSET

EHMT2 NSD1

2.52e-0316882SM00508
DomainPOST_SET

EHMT2 NSD1

2.52e-0316882PS50868
DomainSH3

MYO15B ARHGEF7 MAP3K10 BAIAP2L2 ARHGEF6

3.56e-03216885SM00326
DomainSH3

MYO15B ARHGEF7 MAP3K10 BAIAP2L2 ARHGEF6

3.56e-03216885PS50002
DomainSH3_domain

MYO15B ARHGEF7 MAP3K10 BAIAP2L2 ARHGEF6

3.85e-03220885IPR001452
DomainPH_dom-like

IRS4 KIF1A PHLDA1 ARHGEF7 DOK3 ARHGEF6 PHLPP2

3.97e-03426887IPR011993
DomainKinase-like_dom

AMHR2 TRIB3 COQ8B MAP3K10 PKN2 PLK1 TESK1 SBK3

4.02e-03542888IPR011009
DomainSH3_9

MAP3K10 BAIAP2L2 ARHGEF6

5.96e-0378883PF14604
DomainIPT

PLXND1 PLXNB1

7.14e-0327882SM00429
DomainAT_hook

SRCAP AHDC1

7.14e-0327882SM00384
DomainAT_hook_DNA-bd_motif

SRCAP AHDC1

7.14e-0327882IPR017956
DomainFHA

KIF1A STARD9

7.66e-0328882SM00240
DomainProt_kinase_dom

AMHR2 TRIB3 MAP3K10 PKN2 PLK1 TESK1 SBK3

8.29e-03489887IPR000719
DomainTIG

PLXND1 PLXNB1

9.34e-0331882PF01833
DomainSema

PLXND1 PLXNB1

9.34e-0331882SM00630
DomainSemap_dom

PLXND1 PLXNB1

9.34e-0331882IPR001627
DomainSema

PLXND1 PLXNB1

9.34e-0331882PF01403
DomainSEMA

PLXND1 PLXNB1

9.34e-0331882PS51004
DomainFHA

KIF1A STARD9

9.34e-0331882PF00498
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

FARSA GTF3C1 EHMT2 BACH1 KIF18B EEF1A1

3.69e-0615095630154076
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXND1 PLXNB1 NRP2

4.27e-061295321270798
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXND1 PLXNB1 NRP2

5.54e-061395310520995
Pubmed

C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population.

C2CD4B C2CD4A

7.38e-06295235212842
Pubmed

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.

C2CD4B C2CD4A

7.38e-06295233492421
Pubmed

Polo-like kinase1 is required for recruitment of dynein to kinetochores during mitosis.

DNHD1 PLK1

7.38e-06295221507953
Pubmed

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.

C2CD4B C2CD4A

7.38e-06295229625024
Pubmed

A unique insertion in STARD9's motor domain regulates its stability.

STARD9 PLK1

7.38e-06295225501367
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

EHMT2 JMJD8 NSD1 KDM2A

1.01e-054995434368113
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXND1 PLXNB1 NRP2

1.31e-051795317626059
Pubmed

The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.

ARHGEF7 ARHGEF6 EEF1A1

1.56e-051895319961560
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

CAD IRS4 GTF3C1 LIMD1 NSD1 KDM2A PKN2 SRCAP PLK1

2.01e-0554995938280479
Pubmed

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.

C2CD4B C2CD4A

2.21e-05395220818381
Pubmed

Nuclear receptor binding SET domain protein 1 promotes epithelial-mesenchymal transition in paclitaxel-resistant breast cancer cells via regulating nuclear factor kappa B and F-box and leucine-rich repeat protein 11.

NSD1 KDM2A

2.21e-05395234905470
Pubmed

A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.

C2CD4B C2CD4A

2.21e-05395221799836
Pubmed

Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.

C2CD4B C2CD4A

2.21e-05395227329800
Pubmed

Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.

NSD1 KDM2A

2.21e-05395237311054
Pubmed

Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.

NSD1 KDM2A

2.21e-05395220080798
Pubmed

A novel gene family induced by acute inflammation in endothelial cells.

C2CD4B C2CD4A

2.21e-05395215527968
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NBPF19 CACNA1S PRR14 IRS4 MAP1A AP5B1 NBPF20 GAREM1

2.43e-0543095835044719
Pubmed

Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.

FARSA CAD IRS4 EEF1A1 EEF1A1P5

2.48e-0512595536030824
Pubmed

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.

ARHGEF7 ARHGEF6

4.41e-0549529659915
Pubmed

Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix.

ARHGEF7 ARHGEF6

4.41e-05495215306850
Pubmed

A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins.

ARHGEF7 ARHGEF6

4.41e-05495210428811
Pubmed

The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.

ARHGEF7 ARHGEF6

4.41e-05495215649357
Pubmed

Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels.

CACNA1H ZP4

4.41e-05495220394732
Pubmed

Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.

ARHGEF7 ARHGEF6

4.41e-05495227182061
Pubmed

Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.

ARHGEF7 ARHGEF6

4.41e-05495212499396
Pubmed

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.

ARHGEF6 PLXNB1

4.41e-05495211937491
Pubmed

NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.

NSD1 KDM2A

4.41e-05495235537449
Pubmed

The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.

ARHGEF7 ARHGEF6

4.41e-05495212935897
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

GRAMD2A TRIB3 MEGF8 KCNH2 NSD1 CACNA1H PLXND1 SRCAP TESK1 AHDC1 RASSF7 GAREM1

4.82e-051105951235748872
Pubmed

A human MAP kinase interactome.

MAP1A ARHGEF7 ERRFI1 MAP3K10 OS9 KDM2A CCDC88B GAREM1

5.76e-0548695820936779
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

GTF3C1 EHMT2 KDM2A SRCAP NIPBL

5.92e-0515095528242625
Pubmed

Microglia activation in Niemann-Pick disease, type C1 is amendable to therapeutic intervention.

IRF8 MCOLN1

7.34e-05595229617956
Pubmed

Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway.

ARHGEF7 ARHGEF6

7.34e-05595212006652
Pubmed

The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.

ARHGEF7 ARHGEF6

7.34e-05595211864573
Pubmed

Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

PRR14 EHMT2 NIPBL AHDC1

8.14e-058395420562864
Pubmed

Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases.

EHMT2 NSD1

1.10e-04695224019522
Pubmed

Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development.

AMHR2 PLXND1

1.10e-04695237685880
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

IRS4 LIMD1 MEGF8 STARD9 BACH1 MAP3K10 PLK1 TESK1 RASSF7 EEF1A1

1.24e-04861951036931259
Pubmed

Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.

AMHR2 IRS4 PKN2

1.32e-043695315717329
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

FARSA CAD GTF3C1 MAP1A EHMT2 NOL6 FNDC3A PLK1 NIPBL

1.35e-0470495929955894
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

MYT1L HIC1 ZNF219 GTF3C1 KLF7 LIMD1 KIF1A BACH1 ZNF692

1.43e-0470995922988430
Pubmed

All kinesin superfamily protein, KIF, genes in mouse and human.

KIF1A STARD9 KIF18B

1.43e-043795311416179
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1S CACNA1H

1.54e-04795212900400
Pubmed

The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation.

ARHGEF7 ARHGEF6

1.54e-04795216983070
Pubmed

The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.

ARHGEF7 ARHGEF6

1.54e-04795210896954
Pubmed

N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity.

ARHGEF7 ARHGEF6

1.54e-04795221295525
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

FARSA CAD GTF3C1 MAP1A ARHGEF7 SRCAP NIPBL AHDC1 ARHGEF6 PLXNB1 EEF1A1

1.81e-041082951138697112
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

IRS4 ARHGEF7 ERRFI1 GAREM1

1.88e-0410395421706016
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

FARSA CAD IRS4 GTF3C1 EHMT2 NOL6 PLK1 EEF1A1

2.01e-0458395829844126
Pubmed

Affixin activates Rac1 via betaPIX in C2C12 myoblast.

ARHGEF7 ARHGEF6

2.05e-04895218325335
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1S CACNA1H

2.05e-04895228330839
Pubmed

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

CAD NOL6 EEF1A1

2.41e-044495326471122
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

FAT2 MEGF8

2.62e-0499529693030
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1S CACNA1H

2.62e-04995216382099
Pubmed

The role of neuropilins in cell signalling.

PLXNB1 NRP2

2.62e-04995219909241
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

AMHR2 CAD TRIB3 CFAP77 EHMT2 ARHGEF7 MTBP KDM2A EXOC3L2 PLK1 NIPBL PTGDR2

2.67e-041327951232694731
Pubmed

TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.

PLXND1 PLXNB1 NRP2

2.93e-044795335462405
Pubmed

Identification of DeltaNp63alpha protein interactions by mass spectrometry.

CAD MAP1A EEF1A1

3.12e-044895320085233
Pubmed

Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.

BCL2L12 IRF8

3.28e-041095219798431
Pubmed

Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.

PLXND1 NRP2

3.28e-041095215550623
Pubmed

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.

PLXND1 PLXNB1 NRP2

3.96e-045295326633812
Pubmed

Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.

BCL2L12 IRF8

4.00e-041195220975040
Pubmed

Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.

PLXNB1 NRP2

4.00e-041195225315821
Pubmed

Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function.

MAP1A KIF1A

4.00e-041195217360631
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

CAD GTF3C1 EHMT2 BACH1 PKN2 NIPBL ARHGEF6

4.69e-0450395716964243
Pubmed

New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.

PLXND1 NRP2

4.79e-041295229358640
Pubmed

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.

PLXND1 NRP2

4.79e-041295225839327
Pubmed

A balance of noncanonical Semaphorin signaling from the cerebrospinal fluid regulates apical cell dynamics during corticogenesis.

PLXNB1 NRP2

4.79e-041295236399562
Pubmed

The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections.

PLXND1 NRP2

4.79e-041295225007825
Pubmed

Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.

C2CD4B C2CD4A

4.79e-041295227349930
Pubmed

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

C2CD4B C2CD4A

4.79e-041295221873549
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 FARSA CAD IRS4 GTF3C1 KIF1A STARD9 NOL6 KPRP TESK1 NIPBL EEF1A1

5.06e-041425951230948266
Pubmed

New nomenclature for chromatin-modifying enzymes.

EHMT2 NSD1 KDM2A

5.19e-045795318022353
Pubmed

Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.

IRS4 EEF1A1

5.65e-041395229285303
Pubmed

Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.

FARSA EEF1A1

5.65e-041395211829477
Pubmed

Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation.

PLXND1 NRP2

5.65e-041395226053665
Pubmed

Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.

PLXND1 NRP2

5.65e-041395227880905
Pubmed

Alternative splice variants encoding unstable protein domains exist in the human brain.

FAT2 ARHGEF7

5.65e-041395215491607
Pubmed

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.

PLXNB1 NRP2

6.58e-041495222955271
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

CAD IRS4 ARHGEF7 ARHGEF6 EEF1A1

6.90e-0425595515324660
Pubmed

Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3.

EEF1A1 EEF1A1P5

7.57e-04159528812466
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF219 GTF3C1 EHMT2 BACH1 NSD1 KDM2A KIF18B SRCAP NIPBL AHDC1 EEF1A1P5

8.12e-041294951130804502
Pubmed

A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene.

MAP1A STARD9

8.64e-04169527633422
Pubmed

Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu.

PKN2 PLK1

8.64e-041695223047923
Pubmed

Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.

PLXND1 NRP2

8.64e-041695218489001
Pubmed

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.

PHLDA1 KDM2A EEF1A1

9.08e-046995332238831
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

CAD GTF3C1 KPRP NIPBL EEF1A1

9.21e-0427295531010829
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

SRCAP PLK1 NIPBL AHDC1

9.25e-0415795430686591
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

ZNF219 IRS4 GTF3C1 EHMT2 PLK1 EEF1A1P5

9.42e-0441195635182466
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

PLXND1 PLXNB1

9.78e-041795211683995
Pubmed

Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals.

NEURL3 NRP2

9.78e-041795235079138
Pubmed

Proteome-wide Identification of HtrA2/Omi Substrates.

CAD EEF1A1

9.78e-041795217266347
Pubmed

SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study.

CAD EEF1A1

1.10e-031895236877072
Pubmed

Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.

MYT1L NIPBL

1.10e-031895233323119
Pubmed

Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.

ARHGEF7 ARHGEF6

1.10e-031895212799088
Pubmed

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

KDM2A PLK1

1.10e-031895215070733
Pubmed

Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.

IRS4 KPRP SRCAP

1.20e-037695336560452
GeneFamilyPlexins

PLXND1 PLXNB1

2.77e-049512683
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF1A STARD9 KIF18B

2.95e-0446513622
GeneFamilyNeuroblastoma breakpoint family

NBPF19 NBPF20

1.90e-0323512662
GeneFamilyCalcium voltage-gated channel subunits

CACNA1S CACNA1H

2.43e-0326512253
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

KIF1A ARHGEF7 ARHGEF6 PHLPP2

2.69e-03206514682
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

EHMT2 NSD1

4.13e-0334512487
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

C2CD4B C2CD4A

4.62e-0336512823
CoexpressionGSE17301_CTRL_VS_48H_IFNA2_STIM_CD8_TCELL_DN

PRR14 KLF7 ARHGEF7 TESK1 PTGDR2 PLXNB1 GAREM1

6.94e-06196947M8034
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL

AMHR2 ZNF219 OSTM1 JMJD8 ERRFI1 COQ8B DVL3 CACNA1H AHDC1 RASSF7 PLXNB1 NBPF20 PHLPP2

3.61e-059559413M45680
CoexpressionPRC2_EED_DN.V1_DN

HIC1 CAD EHMT2 PLK1 MCOLN1 PLXNB1

7.01e-05193946M2734
CoexpressionGSE360_CTRL_VS_M_TUBERCULOSIS_MAC_DN

AMHR2 DVL3 PKN2 DLEC1 PLK1 MUC6

8.08e-05198946M5171
CoexpressionGSE360_L_MAJOR_VS_B_MALAYI_HIGH_DOSE_MAC_DN

MYT1L AMHR2 FARSA DLEC1 PLXND1 MUC6

8.30e-05199946M5249
CoexpressionGSE18281_CORTICAL_VS_MEDULLARY_THYMOCYTE_UP

FARSA KLF7 TRIB3 PHLDA1 RNF19B PLXND1

8.30e-05199946M7252
CoexpressionGSE360_CTRL_VS_B_MALAYI_LOW_DOSE_DC_DN

AMHR2 FAT2 KLF7 IRF8 DLEC1 MUC6

8.54e-05200946M5153
CoexpressionGSE360_DC_VS_MAC_L_DONOVANI_DN

AMHR2 ARHGEF7 CACNA1H DLEC1 PLXND1 MUC6

8.54e-05200946M5176
CoexpressionGSE17721_CTRL_VS_PAM3CSK4_2H_BMDC_DN

AMHR2 LIMD1 RNF19B NOL6 RTL8C PTGDR2

8.54e-05200946M3734
ToppCellwk_15-18-Hematologic-Myeloid-Mast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

AMHR2 KCNH2 ENPP3 DOK3 ARHGEF6 PTGDR2

1.76e-06172946a7146c255031207e64682ef767884b11c96e0d59
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CAD ZNF219 OSTM1 EHMT2 NPIPB11 GAREM1

2.15e-061789469d575902d3dbe33437c9d4200df093a741269803
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

AMHR2 KCNH2 ENPP3 SLC22A17 PTGDR2 EEF1A1

3.04e-06189946b46adb47768a7b6d801c457d7ba65508edfc36a5
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-NK|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NBPF19 HIC1 DVL3 CACNA1H PTGDR2 PLXNB1

3.33e-06192946930319cbd82b9e54864147ffcdc8bd0ea7b937be
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NBPF19 HIC1 DVL3 CACNA1H PTGDR2 PLXNB1

3.33e-06192946c7bcebcb88a25b2c97d798120efa9d5958e7f798
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NBPF19 HIC1 DVL3 CACNA1H PTGDR2 PLXNB1

3.53e-061949463211d89440a6f4a9b3d4cfb755890816944242ec
ToppCelldistal-Hematologic-Basophil/Mast_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AMHR2 MAP1A KCNH2 ENPP3 ARHGEF6 EEF1A1

3.64e-061959464f83449fce3717518e2acbba1a4b3bea765c0bdb
ToppCellTCGA-Colorectal-Primary_Tumor|TCGA-Colorectal / Sample_Type by Project: Shred V9

CAD TRIB3 PHLDA1 NOL6 KIF18B ZNF692

4.09e-06199946c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

CAD TRIB3 PHLDA1 NOL6 KIF18B ZNF692

4.09e-0619994685b3b1ad01368dae4adbc9da7efc148e49992f69
ToppCell356C-Myeloid-Mast_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

1.56e-051489451668d8a9e680da335362744f36b05446c499347e
ToppCell356C-Myeloid-Mast_cell-|356C / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

1.56e-0514894518511ba10765eda937c5a710626361f7e6b9b321
ToppCell343B-Myeloid-Mast_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

2.27e-05160945133ecae0a894d9a0d49d58859623359096b6f030
ToppCell343B-Myeloid-Mast_cell-|343B / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

2.27e-05160945a2f09b5955602819c8978f4372130c8ef915cd07
ToppCellcritical-Myeloid-Mast_cell|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

AMHR2 KCNH2 ENPP3 CACNA1H ARHGEF6

2.63e-0516594534a1cc6ccd46c059354e8fbde1ac69f202695a4e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C2CD4B MTBP EXOC3L2 PLK1 EEF1A1

2.95e-05169945db71386408053171363fa8411f5a36c2192487e0
ToppCellfacs-GAT-Fat-24m-Epithelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRAMD2A C2CD4B C2CD4A MTFR2 RASSF7

3.30e-05173945815ba48a9222ea09ba8005e2d2f7c5addf118ad1
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S NEURL3 CFAP77 IRF8 CCDC88B

3.30e-051739457c5e4809205ce1a0a301c15442af00a2e2b9b301
ToppCellfacs-GAT-Fat-24m-Epithelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRAMD2A C2CD4B C2CD4A MTFR2 RASSF7

3.30e-0517394598e464d9e6d6b69421e9e4041b638b6825247f60
ToppCellfacs-GAT-Fat-24m-Epithelial-epithelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRAMD2A C2CD4B C2CD4A MTFR2 RASSF7

3.30e-051739453e6f0a08eddfd61871f7a85acccf6d539af6ebda
ToppCellmoderate-Myeloid-Mast_cell|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

C19orf81 AMHR2 KCNH2 ARHGEF6 PTGDR2

3.49e-05175945bbd2971bc6d69e507f90a637834d0936c205c590
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYO15B MEGF8 RNF19B AHDC1 PHLPP2

3.49e-0517594587e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S JMJD8 ERRFI1 MAP3K10 CACNA1H

3.58e-051769452e9073166da4d9fae70ba4f3fdcad35523caf7cd
ToppCellPSB-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AMHR2 KCNH2 DOK3 ARHGEF6 PTGDR2

3.78e-0517894545bdbb96094c97756e1b6eebd80eadd8472143f2
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF1A KCNH2 NPIPB11 EXOC3L2 KIF18B

4.10e-05181945fe2f8b4bd8b09be8ba933529a16e1dca08740dab
ToppCellcritical-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

AMHR2 KCNH2 ENPP3 CACNA1H ARHGEF6

4.10e-05181945f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells-RBC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF1A KCNH2 NPIPB11 EXOC3L2 KIF18B

4.10e-05181945a16079b1c832456b974d9d06dd1a3eda63ac1bce
ToppCellIPF-Myeloid-Mast|World / Disease state, Lineage and Cell class

AMHR2 KCNH2 ENPP3 CACNA1H ARHGEF6

4.43e-051849457aefa182acad5a53c730945fec85329d7168606a
ToppCellIPF-Myeloid-Mast|IPF / Disease state, Lineage and Cell class

AMHR2 KCNH2 ENPP3 CACNA1H ARHGEF6

4.43e-05184945c3baf21f10b45cf91ac99997a59f353bcf3de8b7
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 C2CD4B RASSF7 BAIAP2L2 PLXNB1

4.66e-0518694537b93ebd64ebbd08193a746e5bc9b350c2570733
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

4.66e-05186945f690e26b2ed024bd8ede494b8e9a00976fdc9734
ToppCellfacs-Trachea-nan-24m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C2CD4B DLEC1 RASSF7 BAIAP2L2 PLXNB1

4.66e-051869456c06163d7315f1c71b15fe76f2e696bf3fa73b67
ToppCellfacs-Trachea-nan-24m-Epithelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C2CD4B DLEC1 RASSF7 BAIAP2L2 PLXNB1

4.66e-0518694578e3b00eb347d1aa197671e31be9b0c6e4235760
ToppCellMast_cells|World / lung cells shred on cell class, cell subclass, sample id

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

4.91e-05188945229d24b87e945c4d543d11ac70761e45175ba0e5
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 C2CD4B RASSF7 BAIAP2L2 PLXNB1

4.91e-051889458ffb5394f7b00ea483a5fe4df894d22fda935e5c
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FAT2 C2CD4B RASSF7 BAIAP2L2 PLXNB1

4.91e-05188945137ed9958044fab7a13648affb469585d1c48cf6
ToppCellMesenchymal_cells-Osteoblasts|World / Lineage and Cell class

AMHR2 KCNH2 BAIAP2L2 PLXNB1 NRP2

4.91e-0518894589f7f5a51be7e046a63e2413f86c521ae4b6718f
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

KLF7 ARHGEF7 ENPP3 ERRFI1 FNDC3A

5.03e-05189945a48df46274d51e84ffb40264646de7346104efb9
ToppCell21-Trachea-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

AMHR2 C2CD4B PLXND1 EXOC3L2 NRP2

5.16e-05190945bce09634acbc2cfd53666328e8aed8bf8835f845
ToppCell21-Trachea-Endothelial-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

AMHR2 C2CD4B PLXND1 EXOC3L2 NRP2

5.16e-0519094508437396a98ca9526f69c3a74bbf2929f3c68b8e
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

AMHR2 KCNH2 ENPP3 ARHGEF6 EEF1A1

5.29e-05191945781f6005673fc3504a85801a68af3e16ca84952f
ToppCellmedial-2-Hematologic-Basophil/Mast_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AMHR2 KCNH2 ENPP3 ARHGEF6 EEF1A1

5.69e-0519494554d33508ce35b3d214214e4efbbb62f358667105
ToppCellmedial-Hematologic-Basophil/Mast_1-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AMHR2 KCNH2 ENPP3 ARHGEF6 EEF1A1

5.69e-05194945a89a03d4adebb9f644c27e199bff267180d8ef18
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

5.69e-051949459d7f232ef5f27c28f325edfa6614f479013acbba
ToppCellmedial-Hematologic-Basophil/Mast_1|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AMHR2 KCNH2 ENPP3 ARHGEF6 EEF1A1

5.69e-05194945ccfc142fe10b4ba16f3036f3f352983ee3e9c8ec
ToppCellPBMC-Control-cDC_11|Control / Compartment, Disease Groups and Clusters

GRAMD2A ENPP3 IRF8 PLK1 PLXNB1

5.83e-0519594574d560ff0f47512441c305885c5c16272f711b8e
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

5.83e-05195945f1f48e2e57b2282572959b152aad4bee05143f03
ToppCelldistal-2-Hematologic-Basophil/Mast_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AMHR2 KCNH2 ENPP3 ARHGEF6 EEF1A1

5.98e-05196945ad21706a281f0b105eb3979e3e47fe0cec6c527f
ToppCelldistal-Hematologic-Basophil/Mast_1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

AMHR2 KCNH2 ENPP3 ARHGEF6 EEF1A1

5.98e-051969453df0f8fce94bd573f9f9dfeb06d5f68202627740
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

5.98e-05196945e08f90f7a923c2846cac859519b8dc7c0ac7cd03
ToppCell10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

AMHR2 ENPP3 ARHGEF6 PTGDR2 EEF1A1

5.98e-05196945ef481eb306350311207f7a29fdfa1ae3feaba4d7
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF19B BACH1 ERRFI1 GAREM1 EEF1A1

5.98e-0519694597ac47daf5bb07fa5dda3976e1ae402750f959b5
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4-POLYDENDROCYTE_(Rostral-�migratory_stream-�(RMS)_(Tuba1c))|Striatum / BrainAtlas - Mouse McCarroll V32

ENPP3 MTFR2 KIF18B PLK1

6.25e-051019440b32e6071f05dbe808e51e18c3a3f8221f438f83
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BCL2L12 PHLDA1 C2CD4A KIF18B PLK1

6.27e-051989451fa213e79d828bff6465bde116536dd1b80d94e0
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MAP1A KIF1A PRR18 SLC22A17 PLXNB1

6.42e-051999455d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MAP1A KIF1A PRR18 SLC22A17 PLXNB1

6.42e-051999459dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MAP1A KIF1A PRR18 SLC22A17 PLXNB1

6.42e-051999456fb5f931e6217142de38c1fffc011e63bda4772b
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MAP1A KIF1A PRR18 SLC22A17 PLXNB1

6.42e-051999451bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCellLung_Parenchyma-Severe-Myeloid-Mast_cell-Mast_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

6.58e-052009454090f2ab8529a530043f3917472f2d9ca7c9b1df
ToppCellLung_Parenchyma-Severe-Myeloid-Mast_cell|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

6.58e-05200945cc78aa3e29f6c0a44c373dde7785c0e61978cf2d
ToppCellBiopsy_IPF-Immune-Mast_cells|Biopsy_IPF / Sample group, Lineage and Cell type

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

6.58e-0520094544d07a3fa768ccdcd2a0483a41483d5c11c9111e
ToppCellLung_Parenchyma-Severe-Myeloid-Mast_cell-Mast_cells|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

6.58e-05200945c3150b4bb621534b0094306b29534dbbe4ef7357
ToppCellParenchyma_COVID-19-Immune-TX-Mast_cells|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

6.58e-0520094556e2284df161e8ca32ce3e358369611345f4414e
ToppCellParenchymal-10x5prime-Immune_Myeloid-Mast_cell-Mast_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

6.58e-052009458943278190f42016ee914e584d1b6b9aeaf7c73f
ToppCellBiopsy_Control_(H.)-Immune-Mast_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

6.58e-0520094564bf125e0e5652a5a638a6bb32eb109cb0d5e232
ToppCellParenchymal-10x5prime-Immune_Myeloid-Mast_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AMHR2 KCNH2 ENPP3 ARHGEF6 PTGDR2

6.58e-05200945ea52df18400550b65de142d03b3b0963436e03d9
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

NEURL3 IRF8 GAL3ST4 CCDC88B

1.52e-041279440750743574c2fca8df07e11d73e8b94579209609
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gabrg1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KIRREL3 PHLDA1 STARD9 BAIAP2L2

2.20e-041409442c44e8cc5190226049be7ebc465d685393e701c4
ToppCellControl-Classical_Monocyte-cMono_3|Control / Disease condition and Cell class

PHLDA1 RNF19B BACH1 NRP2

2.39e-041439449d1cee36e32aefb6af5c65b3281b31a45d5cd17e
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-NP-L6_NP_ALM_Trh|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

AMHR2 KIRREL3 CCDC88B NRP2

2.80e-04149944fe9dff31a30dabd212d53d1295f9f13ff32cb217
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PHLDA1 KCNH2 STARD9 ARHGEF6

2.80e-041499441e77f03d2b32f366018fec3462d1b75f6e7febb9
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NRSN2 MTFR2 KIF18B PLK1

2.80e-041499442624ad3926efc9f0f169daae263cef16861f132b
ToppCell368C-Myeloid-Mast_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 ENPP3 ARHGEF6

3.02e-04152944faf30245a1690aaa27c7be0832797c340e4af4d7
ToppCell368C-Myeloid-Mast_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 ENPP3 ARHGEF6

3.02e-04152944519c9ed05fdaf420e42147ffae1dc05a7f86fdd4
ToppCellBronchial_Biopsy-Epithelial-Goblet_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

IZUMO4 AP5B1 DOK3 BAIAP2L2

3.09e-04153944e9d6b4e895ddb8d6e6c8b043da591ec11365e124
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NRSN2 MAP1A DLEC1 CFAP65

3.17e-041549449ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NRSN2 MAP1A DLEC1 CFAP65

3.17e-0415494458072ce422d09f2de602580325eaac6c4ec6c136
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

MAP1A IRF8 NBPF20 PHLPP2

3.33e-0415694419472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

KCNH2 ENPP3 CACNA1H ARHGEF6

3.33e-04156944bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCellNS-moderate-d_07-13-Myeloid-Mast_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

C19orf81 AMHR2 KCNH2 ARHGEF6

3.33e-0415694417c38d3b03fc38cb125cf0d165b2fd694cd88edd
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

KCNH2 ENPP3 CACNA1H ARHGEF6

3.33e-04156944159504d43421ee83b9ab484816333ae549c9c2fd
ToppCellfacs-Trachea-nan-18m-Myeloid-lymphocyte_of_B_lineage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S DOK3 KDM2A CACNA1H

3.66e-041609445c9281706009558c8361bfa76169f43ffc0f7947
ToppCellCOPD-Epithelial-PNEC|World / Disease state, Lineage and Cell class

MYT1L KIF1A KCNH2 CACNA1H

3.66e-04160944cdea93317b0ebb801ddbe73bca6149ce2c727f16
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S IRF8 CCDC88B ARHGEF6

3.75e-0416194416f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S IRF8 CCDC88B ARHGEF6

3.75e-04161944f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S IRF8 CCDC88B ARHGEF6

3.75e-0416194458a32a1033f379579697bda1bbf047a088e4a34f
ToppCellhuman_hepatoblastoma-Tumor_cells-T7|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

MAP1A PLK1 MUC6 GAREM1

3.84e-04162944c6ace47daf32495b25793d39b72382978349597d
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-B_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1S DOK3 KDM2A CACNA1H

4.02e-041649444274a4f225cabf61f0fe27d8ea162b4eba612f87
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-B_cell-B_cell_of_the_trachea|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1S DOK3 KDM2A CACNA1H

4.02e-04164944d62143450f59097ad4b34603a6257f897a769ead
ToppCell356C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 SLC22A17 PTGDR2

4.02e-04164944b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCellNS-moderate-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AMHR2 KCNH2 ARHGEF6 PTGDR2

4.02e-0416494435c673380f75cb4bfe080089bc723c4373bcc7a5
ToppCell356C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 SLC22A17 PTGDR2

4.02e-04164944f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1S CACNA1H PLK1 PHLPP2

4.02e-04164944b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCellfacs-MAT-Fat-3m-Myeloid-macrophage|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BACH1 PLXND1 CCDC88B ARHGEF6

4.02e-04164944b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1S CACNA1H PLK1 PHLPP2

4.02e-04164944a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STARD9 RNF19B NOL6 IRF8

4.11e-0416594476abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1L C19orf81 NRSN2 IRS4

4.11e-041659446d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCelldroplet-Thymus-nan-21m-Myeloid-Plasma_cells_and_B_cells|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S FNDC3A CACNA1H DLEC1

4.11e-0416594421a82a975f550080b6674750b06212205cd16742
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1L C19orf81 NRSN2 IRS4

4.11e-0416594402cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCell343B-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

AMHR2 KCNH2 ENPP3 PTGDR2

4.21e-041669444e47e7f3019fb2dcbc35b4e9b47ee265a97cec5c
ToppCellLAM-Myeloid-Mast|LAM / Condition, Lineage and Cell class

AMHR2 KCNH2 ENPP3 ARHGEF6

4.21e-04166944e0ce973cc2a091b832c67b3b32dc153379daa2ef
DrugLY 294002; Down 200; 10uM; HL60; HT_HG-U133A

FARSA NOL6 IRF8 PLXND1 RTL8C ZNF692 RASSF7

1.13e-051889271177_DN
DrugLY 294002; Down 200; 10uM; HL60; HT_HG-U133A

GTF3C1 PHLDA1 RNF19B NOL6 PLXND1 ZNF692 RASSF7

1.17e-051899271168_DN
Drugscriptaid; Down 200; 10uM; PC3; HT_HG-U133A

FARSA CAD TRIB3 PHLDA1 DVL3 NSD1 PLK1

1.30e-051929276919_DN
DrugFamprofazone [22881-35-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A

MEGF8 PHLDA1 KCNH2 CACNA1H SRCAP SLC22A17 ARHGEF6

1.44e-051959273834_UP
DrugMeclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; HL60; HT_HG-U133A

ZNF219 DOK3 KDM2A SRCAP TESK1 MCOLN1 RASSF7

1.49e-051969272424_DN
Drug(+/-)-thalidomide; Up 200; 100uM; MCF7; HG-U133A

GTF3C1 PHLDA1 FNDC3A DLEC1 PLXND1 TESK1 RASSF7

1.59e-05198927266_UP
DrugLY-171,883; Up 200; 1uM; MCF7; HG-U133A

PHLDA1 BACH1 FNDC3A DLEC1 MCOLN1 SLC22A17 PLXNB1

1.64e-05199927222_UP
Diseasedevelopmental and epileptic encephalopathy 33 (implicated_via_orthology)

EEF1A1 EEF1A1P5

2.69e-053892DOID:0080463 (implicated_via_orthology)
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

PLXND1 SRCAP PLXNB1

4.42e-0449893DOID:0060037 (implicated_via_orthology)
DiseaseCooley's anemia

CAD CACNA1H

5.82e-0412892C0002875
DiseaseThalassemia Minor

CAD CACNA1H

5.82e-0412892C0085578
DiseaseThalassemia Intermedia

CAD CACNA1H

5.82e-0412892C0271979
Diseasebeta Thalassemia

CAD CACNA1H

5.82e-0412892C0005283
DiseaseHemoglobin F Disease

CAD CACNA1H

9.21e-0415892C0019025
Diseasesex interaction measurement, ulcerative colitis

EHMT2 OS9

1.19e-0317892EFO_0000729, EFO_0008343
Diseasesensory peripheral neuropathy, remission

DLEC1 PRR18

2.18e-0323892EFO_0009785, MONDO_0002321
Diseasesmoking behavior, BMI-adjusted waist-hip ratio

EHMT2 NSD1 PLXND1

2.27e-0386893EFO_0004318, EFO_0007788
Diseasenephrotic syndrome (implicated_via_orthology)

KIRREL3 COQ8B

2.38e-0324892DOID:1184 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

MYT1L SRCAP PLXNB1

2.83e-0393893C1535926
Diseasefactor VIII measurement, von Willebrand factor measurement

KIRREL3 C2CD4B

3.01e-0327892EFO_0004629, EFO_0004630

Protein segments in the cluster

PeptideGeneStartEntry
ADIPVPRPSFCLSLP

EXOC3L2

361

Q2M3D2
SLSDRPPAVLPPCAR

BACH1

671

O14867
LSCLRPAPPLRPSAA

ARHGEF6

591

Q15052
FLSTLPTRPEPELPC

ANKRD18A

936

Q8IVF6
SQVCPPPRRPLTVAD

CFAP77

26

Q6ZQR2
PLCLRPEAPSRAPAE

CCDC88B

236

A6NC98
LPRASCRLGEEPPPL

C19orf48

56

Q6RUI8
AAPSESPRPCSLPIR

BCL2L12

146

Q9HB09
PRRPPCDPLADTIDS

EHMT2

591

Q96KQ7
SLSCLRPAPPLRPSA

ARHGEF7

651

Q14155
LERELVSGPLPCRLP

DNHD1

1861

Q96M86
ELRPPPTKLAACEPL

AHDC1

1411

Q5TGY3
TLPRSEPIRPIDPAA

DVL3

346

Q92997
IPAPTILPCRPQRSA

AMHR2

536

Q16671
VTCPNRPLVPRPLLT

CECR9

41

P0C854
PPPERCLIRASLPVK

RASSF7

101

Q02833
PLLPERPLERTDSRP

NSD1

2276

Q96L73
APPTPPEEEDLRRRL

MCOLN1

31

Q9GZU1
LCPEPPETRVSHLRP

FAM47C

606

Q5HY64
LELPCPDPSTPGRRL

MUC6

2406

Q6W4X9
LDRELPCIRKFPTPP

C19orf81

61

C9J6K1
TLPIPSTCPEPFARL

MAP3K10

321

Q02779
SRPDTLLSPEQPVCP

MAP1A

2401

P78559
SPSSPRVRLPCQPLV

LIMD1

421

Q9UGP4
ERPLAERELPPRPDS

HIC1

256

Q14526
PRVIALPPFCVPRSL

CFAP65

1886

Q6ZU64
LPPFCVPRSLTPDTL

CFAP65

1891

Q6ZU64
ELPRCPAPTPSLLNI

KCNH2

1011

Q12809
GRLTPTCLDMPPRPL

BAIAP2L2

246

Q6UXY1
PPRLPAPCTLESPIR

C2CD4B

36

A6NLJ0
RCETSPRPTPATLPV

PLXNB1

1216

O43157
DCPRTLLSPLAPVPT

PLXND1

751

Q9Y4D7
PPSPRERLVAPCLNE

FAT2

4256

Q9NYQ8
RSPSPPEACRSQLLP

IRF8

161

Q02556
ECRLLNAPPVPPRSA

GAREM1

526

Q9H706
ESCPRPPETPVSRLR

FAM47B

186

Q8NA70
SLPCSSPRDVPPDIL

NIPBL

301

Q6KC79
RLISPPVHLPRSPVC

NRP2

701

O60462
ERLVTVRLHPCPPPD

NOL6

246

Q9H6R4
TLPPDPCRLLSSPEA

MEGF8

1871

Q7Z7M0
RERLPELTRPQPCPL

DOK3

311

Q7L591
ELTRPQPCPLPRATS

DOK3

316

Q7L591
QPCPLPRATSLPSLD

DOK3

321

Q7L591
PPPCIEESFRRLDPL

KLF7

66

O75840
LPLQPRCPAPARLDV

AP5B1

726

Q2VPB7
LSDDPEGPPVLCPRR

NRSN2

41

Q9GZP1
LSLPPDLPDLDPECR

OSTM1

71

Q86WC4
LRPALPSCPPRQRLV

GAL3ST4

56

Q96RP7
LPELPLSPLCPSNRR

KIF18B

816

Q86Y91
LCSRPEEPRGPARLL

PTGDR2

356

Q9Y5Y4
PLECLLTPLPPSADD

NPIPB11

266

E5RHQ5
SITECLPPEVPARPS

MYO15B

451

Q96JP2
VLRPLRSCDEPLTPP

KDM2A

701

Q9Y2K7
PEILPRPPRALFCLT

CACNA1S

21

Q13698
PLPPTVPDCLRADVR

ENPP3

656

O14638
TLSCEPDIPNPPRIA

FNDC3A

366

Q9Y2H6
ALDCILPPTRPTDKP

EEF1A1

231

P68104
PVLLRHRLCPPPEET

COQ8B

471

Q96D53
ALDCILPPTRPTDKP

EEF1A1P5

231

Q5VTE0
SRPARLTVLVPPDDP

KIRREL3

136

Q8IZU9
VEPLPPRCLSQPSER

KIAA1210

1046

Q9ULL0
SCPELRPHVEPRPLP

KPRP

366

Q5T749
PRLRPEPCISLEPRP

KPRP

406

Q5T749
EPCISLEPRPRPLPR

KPRP

411

Q5T749
SRSLSLPDNIPCIPP

GRAMD2A

216

Q8IUY3
AESLDPRPLRPAALP

CACNA1H

1196

O95180
APSLRASLPLEPPRC

RTL8C

36

O15255
ASLPLEPPRCPLRSC

RTL8C

41

O15255
RRPPPVLTLSPVLDC

DLEC1

471

Q9Y238
PELCLLLPPDTLPLR

SBK3

206

P0C264
PAFLVSPALRCLEPP

IZUMO4

201

Q1ZYL8
SPSAEPRRLLAPCLP

PRR18

166

Q8N4B5
LTPDRIPEFCIPPRL

C2CD4A

41

Q8NCU7
PPLCKDVLSPLRPSR

KIF1A

1086

Q12756
TERSLPVTCPLVPIP

MTBP

781

Q96DY7
SPSRCSEPPPVARLL

IRS4

1061

O14654
LPPERAPRLLSCPHR

RNF19B

126

Q6ZMZ0
PLCRLDAEPRPPPTQ

FARSA

491

Q9Y285
LLRQPPPTRCDHVPL

SLC22A17

516

Q8WUG5
GPPCPRLSRELLEVV

NBPF19

1956

A0A087WUL8
GPPCPRLSRELLEVV

NBPF19

3176

A0A087WUL8
GPPCPRLSRELLEVV

NBPF20

636

P0DPF2
GPPCPRLSRELLEVV

NBPF20

1856

P0DPF2
GPPCPRLSRELLEVV

NBPF20

3076

P0DPF2
GPPCPRLSRELLEVV

NBPF20

4296

P0DPF2
PPDPLCLCREPLSRI

PRR14

106

Q9BWN1
VSLPRVPSPEPRLLE

STARD9

2526

Q9P2P6
TSEAPILTPPREPRI

PKN2

951

Q16513
RRVLLEVATAPDPPP

SRCAP

971

Q6ZRS2
CERGSRPLPPLPISE

ERRFI1

146

Q9UJM3
TIRTPRLCPHPLLRP

OS9

221

Q13438
LPRPERRCSLHPTPT

PHLPP2

1111

Q6ZVD8
RDPEPPPPLCLLRVS

PHLDA1

81

Q8WV24
CLLPLSPPTAPDRAT

TRIB3

46

Q96RU7
PARRCRSLPSSPELP

TESK1

431

Q15569
LPPTLVSRLPAPVRC

PYCARD-AS1

111

I3L0S3
RERLTERLCPPGIPT

CAD

371

P27708
PLEPCRRPNFELIPL

MTFR2

46

Q6P444
TRLDPACVSVPSLPP

NEURL3

81

Q96EH8
PTPPLQLRCDRDERP

nan

261

Q8N9G6
SRLETRVPPFPLPLE

GTF3C1

26

Q12789
CTPVPARLRPAAAPL

GTF3C1

1681

Q12789
LLLAPAPTPAERREP

ZNF219

361

Q9P2Y4
IPARDRLPCAPSPIS

ZP4

146

Q12836
SEPDAPRLLPSPVTC

ZNF692

221

Q9BU19
PARLPITCLTIPPRF

PLK1

311

P53350
PALPPSARPLECTIR

JMJD8

221

Q96S16
RPRDSCCPILTPLEP

MYT1L

781

Q9UL68