Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmethionine adenosyltransferase activity

MAT1A MAT2A

9.49e-062622GO:0004478
GeneOntologyCellularComponentmethionine adenosyltransferase complex

MAT1A MAT2A

2.51e-053612GO:0048269
GeneOntologyCellularComponentorganelle envelope lumen

FKBP10 IGF2R SUOX IMMT

2.25e-04102614GO:0031970
DomainS-AdoMet_synt_M

MAT1A MAT2A

1.01e-052602PF02772
DomainS-AdoMet_synt_C

MAT1A MAT2A

1.01e-052602PF02773
DomainADOMET_SYNTHASE_CS

MAT1A MAT2A

1.01e-052602IPR022631
DomainS-AdoMet_synt_C

MAT1A MAT2A

1.01e-052602IPR022630
DomainS-AdoMet_synthetase_sfam

MAT1A MAT2A

1.01e-052602IPR022636
DomainS-AdoMet_synt_N

MAT1A MAT2A

1.01e-052602PF00438
DomainS-AdoMet_synt_central

MAT1A MAT2A

1.01e-052602IPR022629
DomainS-AdoMet_synt_N

MAT1A MAT2A

1.01e-052602IPR022628
DomainS-AdoMet_synthetase

MAT1A MAT2A

1.01e-052602IPR002133
DomainADOMET_SYNTHASE_1

MAT1A MAT2A

1.01e-052602PS00376
DomainADOMET_SYNTHASE_2

MAT1A MAT2A

1.01e-052602PS00377
DomainRCC1

ALS2 HERC2 NEK9

3.46e-0520603PF00415
DomainRCC1_1

ALS2 HERC2 NEK9

4.02e-0521603PS00625
DomainRCC1_2

ALS2 HERC2 NEK9

4.02e-0521603PS00626
DomainRCC1_3

ALS2 HERC2 NEK9

4.02e-0521603PS50012
DomainReg_chr_condens

ALS2 HERC2 NEK9

4.65e-0522603IPR000408
Domain-

ALS2 HERC2 NEK9

4.65e-05226032.130.10.30
DomainRCC1/BLIP-II

ALS2 HERC2 NEK9

5.33e-0523603IPR009091
DomainCYTOCHROME_B5_2

SUOX HERC2

7.74e-0413602PS50255
DomainCYTOCHROME_B5_1

SUOX HERC2

7.74e-0413602PS00191
DomainCyt-b5

SUOX HERC2

9.01e-0414602PF00173
DomainCyt_B5-like_heme/steroid-bd

SUOX HERC2

9.01e-0414602IPR001199
DomainCyt-b5

SUOX HERC2

9.01e-0414602SM01117
Domain-

SUOX HERC2

9.01e-04146023.10.120.10
DomainGRAM

WBP2 OXR1

2.25e-0322602PF02893
DomainGRAM

WBP2 OXR1

2.25e-0322602IPR004182
DomainKringle-like

IGF2R F2

4.73e-0332602IPR013806
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ERBB2 IGF2R SLC37A3 RPS6KA2 LMTK2 EML2 TNKS1BP1 IRS1 TNRC6C SLC45A1 HERC2 DCTN1 RAI1

9.16e-081105641335748872
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

PLBD1 ERBB2 SUOX TNKS1BP1 DCTN1 NNT NEK9

1.48e-0630464732235678
Pubmed

Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study.

WBP2 ERBB2

3.33e-06264230593516
Pubmed

Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.

MAT1A MAT2A

3.33e-06264222318685
Pubmed

S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.

MAT1A MAT2A

3.33e-06264227076759
Pubmed

Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer.

ERBB2 HPSE

3.33e-06264220164500
Pubmed

[Correlation between lymph-node metastasis and combined expression of Hpa and C-erbB-2 of invasive ductal breast carcinoma].

ERBB2 HPSE

3.33e-06264218390199
Pubmed

A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.

MAT1A MAT2A

3.33e-06264229749642
Pubmed

Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.

MAT1A MAT2A

3.33e-06264231234428
Pubmed

Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.

MAT1A MAT2A

3.33e-06264229448301
Pubmed

Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.

PRKAB1 IRS1

9.99e-06364217459875
Pubmed

Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.

MAT1A MAT2A

9.99e-06364223425511
Pubmed

Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterization.

MAT1A MAT2A

9.99e-0636427213623
Pubmed

Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.

IRS1 HPSE

9.99e-06364223048032
Pubmed

Structure and function study of the complex that synthesizes S-adenosylmethionine.

MAT1A MAT2A

9.99e-06364225075345
Pubmed

Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†.

MAT1A MAT2A

9.99e-06364230265288
Pubmed

A genome-wide association meta-analysis of preschool internalizing problems.

PCSK2 TENM3

6.96e-05764224839885
Pubmed

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

FKBP10 ERBB2

6.96e-0576427590247
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

LOXHD1 IRS1 HERC2

7.46e-054464327534441
Pubmed

Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.

MAT1A MAT2A

9.27e-05864219158324
Pubmed

Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development.

ERBB2 RPS6KA2

1.19e-04964215582777
Pubmed

Identification of transcripts with enriched expression in the developing and adult pancreas.

GPD2 PCSK2 PAMR1 SUOX MAT1A UBE2C REG1A

1.48e-0462464718554416
Pubmed

Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.

IGF2R IRS1

1.49e-041064220416304
Pubmed

Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.

IGF2R IRS1

1.49e-041064221852217
Pubmed

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

ERBB2 IGF2R KCNQ4 RPS6KA2 PRKAB1

1.58e-0427664528319085
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ERBB2 RPS6KA2 EIF4B LMTK2 ALS2 TNKS1BP1 IRS1 NEK9

1.78e-0486164836931259
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

GPD2 WBP2 FKBP10 IGF2R MAT2A EIF4B DCTN1 NNT PGD IMMT

1.87e-041367641032687490
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IGF2R TNKS1BP1 HERC2 FSCN1 NNT IMMT RAI1

1.96e-0465364722586326
Pubmed

Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.

PCSK2 IRS1

2.17e-041264215587270
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

GPD2 DNAAF10 MAT2A EIF4B PPIL2 TNKS1BP1 FSCN1 DCTN1 NEK9 IMMT

2.46e-041415641028515276
Pubmed

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

LIG4 ERBB2 IGF2R F2

2.79e-0417064419064572
Pubmed

Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization.

IRS1 NEK9

2.99e-041464234674267
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

GPD2 ERBB2 IGF2R MAT2A EIF4B TNKS1BP1 IMMT

3.20e-0470864739231216
Pubmed

The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.

GPD2 FKBP10 DCTN1 NNT NEK9

3.35e-0432564536168628
Pubmed

1.3 A X-ray structure of an antibody Fv fragment used for induced membrane-protein crystallization.

IGHV3-53 IGHV3-48

3.45e-041564212657787
Pubmed

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

MAT1A MAT2A EYA1 FSCN1 RAI1

3.65e-0433164520634891
Pubmed

A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.

LIG4 ERBB2 IGF2R

3.65e-047564320644561
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

TNRC6C HERC2 NEK9

3.80e-047664327542412
Pubmed

TRIM24 is an insulin-responsive regulator of P-bodies.

TNKS1BP1 TNRC6C IMMT

4.41e-048064335803934
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

EIF4B SLC25A29 FSCN1 DCTN1 PGD IMMT MAP3K19

4.66e-0475464735906200
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

FKBP10 IGF2R SLC39A6 TNRC6C HERC2 NNT NEK9

4.66e-0475464733060197
Pubmed

Localization of three genes expressed in retina on mouse chromosome 11.

FKBP10 ERBB2

5.00e-04186427767000
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

LIG4 LOXHD1 PRKAB1 EML2 ALS2 HERC2 FSCN1 DCTN1 NEK9

5.49e-04128464917353931
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

WBP2 OXR1 FEZF2 MAT2A NAV3 ANKRD36 HERC2 DCTN1 IMMT

5.52e-04128564935914814
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

ERBB2 IGF2R TENM3 EIF4B TNKS1BP1 FSCN1

6.04e-0456564625468996
Pubmed

Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.

ERBB2 UBE2C

6.20e-042064215504738
Pubmed

A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors.

MALRD1 TENM3

6.20e-042064235224516
Pubmed

Scanning the human proteome for calmodulin-binding proteins.

PPIL2 HERC2 IMMT

6.64e-049264315840729
Pubmed

In silico QTL mapping of basal liver iron levels in inbred mouse strains.

IGF2R LMTK2

6.84e-042164221062905
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

GPD2 WBP2 ERBB2 CACNG6 IGF2R SLC45A1 FSCN1 NEK9

7.13e-04106164833845483
Pubmed

Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal.

ERBB2 F2

7.52e-042264230870413
Pubmed

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.

IGHV3-53 IGHV3-48

7.52e-04226422499654
Pubmed

Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation.

ABCC9 PGD

8.23e-042364225775596
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ALS2 ANKRD36 TNRC6C

8.71e-0410164310997877
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

ERBB2 FSCN1 DCTN1 NNT PGD IMMT

8.77e-0460764639147351
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TENM3 NAV3 ALS2 TNRC6C KLHL32

9.27e-0440764512693553
Pubmed

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

IGF2R NEK9

1.05e-032664224067654
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

WBP2 ERBB2 IGF2R TENM3 SLC39A6

1.08e-0342164536976175
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

TNKS1BP1 HERC2 DCTN1 NEK9

1.13e-0324764432989298
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

GPD2 IGF2R MAT2A FSCN1 NNT PGD IMMT

1.14e-0387864737223481
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

GPD2 IGF2R MAT2A F2 DCTN1 NNT PGD NEK9 IMMT

1.15e-03142564930948266
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

FKBP10 DNAAF10 MAT2A EIF4B FSCN1 DCTN1 PGD NEK9

1.19e-03114964835446349
Pubmed

WFS1 Spectrum Disorder

GPD2 IRS1

1.22e-032864220301750
Pubmed

Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.

MAT1A MAT2A

1.31e-032964219048631
Pubmed

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.

TENM3 FEZF2

1.31e-032964220615956
Pubmed

Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos.

UBE2C FSCN1

1.40e-033064238636517
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

MAT1A MAT2A EIF4B NNT IMMT

1.46e-0345164536168627
Pubmed

Specific functions for ERK/MAPK signaling during PNS development.

ERBB2 RPS6KA2

1.50e-033164221220101
Pubmed

Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.

EIF4B TNKS1BP1

1.60e-033264219542561
Pubmed

Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.

MAT1A MAT2A

1.70e-033364234702858
Pubmed

Amyotrophic Lateral Sclerosis Overview

ALS2 DCTN1

1.70e-033364220301623
ToppCellMonocytes-Tissue-resident_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

RPS6KA2 EIF4B PRKAB1 ANKRD36 ANKRD36C

7.92e-06193635198552810dcac8d0ca63a78badd6702b49ff6edf
ToppCell(5)_Fibroblast-E|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FKBP10 PAMR1 NAV3 ABCC9 VIT

9.41e-0620063575e5ecb05e965e24d569aa2ef5cdf740b1528c06
ToppCellParenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-53 FKBP10 PAMR1 VIT

5.32e-05145634e808502fa52baf1c400f3c9b918a167127e78af9
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PAMR1 FEZF2 MAT1A CDHR1

5.91e-051496348638b3819193d11411df58964069fec583f617f4
ToppCellfacs-Thymus-Epithelium-3m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 FEZF2 IRS1 EYA1

8.18e-051626343dc39db0d5f6f3d7bcc312a6bce7aaeb914138d1
ToppCellfacs-Thymus-Epithelium-3m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 FEZF2 IRS1 EYA1

8.18e-051626340a7138266054ea5954649c8b61ef93905d56b068
ToppCellfacs-Thymus-Epithelium-3m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 FEZF2 IRS1 EYA1

8.18e-0516263425323785dd33337bcefd05958a4a1a208a9ceb04
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLBD1 IGF2R KCNQ4 HPSE

8.78e-05165634ab6ed7e30096c418e7be2d5eec33feeddd1387d9
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLBD1 DGKG HPSE PGD

8.98e-0516663482fa07632f7e586698fbf37381715b40f9f6ae3a
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLBD1 DGKG HPSE PGD

8.98e-051666340d03926452414f232c77fd15d5f48d148f9fca3b
ToppCellBL-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GARNL3 TENM3 KCNQ4 NAV3

9.85e-05170634b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GARNL3 FEZF2 DGKG ABCC9

9.85e-05170634417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCellwk_08-11-Hematologic-Meg-ery-Megakaryocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

LOXHD1 KCNQ4 DGKG HPSE

1.01e-041716349dda25df493766723335851b3c3d89735b6e8051
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLBD1 FEZF2 DGKG ABCC9

1.03e-041726341cfea985c5959b38beea351b892cd5e92e27f927
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIG4 KCNQ4 ABCC9 TNKS1BP1

1.05e-04173634d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 PLBD1 LMTK2 EYA1

1.05e-04173634c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIG4 KCNQ4 ABCC9 TNKS1BP1

1.05e-041736343c852ffe22f4a5b632463086b08c669310684e80
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PCSK2 CACNG6 FEZF2 MAP3K19

1.10e-04175634ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell10x3'2.3-week_17-19-Neuro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK2 ERBB2 TENM3 SLC5A12

1.10e-04175634bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCell10x3'2.3-week_17-19-Neuro-stroma-schwann_cells|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK2 ERBB2 TENM3 SLC5A12

1.10e-041756348b010220cdfb680ec839572f4933adfb85045ea6
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PCSK2 CACNG6 FEZF2 MAP3K19

1.10e-0417563421f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell10x3'2.3-week_17-19-Neuro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK2 ERBB2 TENM3 SLC5A12

1.10e-041756340b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_early_2|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

PAMR1 REG1A VIT MAP3K19

1.13e-041766348e0ac3ad5e47614b4befabd674a40e3eaae553f3
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GARNL3 RPS6KA2 IRS1 SLC45A1

1.15e-04177634e65c0568dc5852108e9802273499bc7cf88fafab
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 SLC39A6 IRS1 KLHL32

1.18e-04178634fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAT1A EYA1 KLHL32 MAP3K19

1.18e-04178634de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERBB2 LMTK2 ANKRD36C RAI1

1.20e-041796346e965e424eebef50f0202cff75f458be395cfca1
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK2 TENM3 DGKG VIT

1.20e-04179634747a32460b257fffca30527b56a74720eb9c12e4
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 FEZF2 DGKG ABCC9

1.23e-04180634e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FKBP10 PAMR1 NAV3 ABCC9

1.25e-04181634c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FKBP10 PAMR1 NAV3 ABCC9

1.25e-04181634c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 UBE2C EYA1 FSCN1

1.25e-04181634f2ebeb4941510c4b6e50f2379c574d1778d6ced1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 FEZF2 DGKG ABCC9

1.28e-0418263472e65a23cd36085bc880087d3cae92395de918a1
ToppCell21-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high|Trachea / Age, Tissue, Lineage and Cell class

FKBP10 PAMR1 VIT BAIAP2L2

1.28e-04182634354dcdb01360597f68c4fe157a682aee1c0b8bb1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 FEZF2 DGKG ABCC9

1.28e-0418263405c167158815bf25d509df59ab386e1990712765
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KCNQ4 RPS6KA2 DGKG ABCC9

1.34e-04184634689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KCNQ4 RPS6KA2 DGKG ABCC9

1.34e-04184634327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

PAMR1 NAV3 ABCC9 VIT

1.36e-04185634a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

IGF2R REG1A ANKRD36 ANKRD36C

1.45e-04188634ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.51e-041906342306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PAMR1 NAV3 ABCC9 VIT

1.51e-04190634efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.51e-041906341f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.54e-04191634a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PLBD1 LOXHD1 IGF2R PGD

1.54e-04191634d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCellfacs-Pancreas|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK2 PAMR1 RPS6KA2 KLHL32

1.54e-04191634d48e5f67d384226add7d7fb2a124954136e09a82
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.57e-041926349093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.57e-041926349ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TENM3 NAV3 ABCC9 HPSE

1.57e-0419263420ede290e01ad574afd122d72b59dbc52c595fad
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.60e-04193634f1199518c3626fd29bfce65070dd21a660671213
ToppCellcontrol-Myeloid-Neutrophils_3|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PLBD1 IGF2R SLC37A3 PGD

1.60e-0419363456daf3c59a124dd068af5409113913d9ee81a454
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FKBP10 PAMR1 ABCC9 VIT

1.64e-0419463402b8102be9414d6964cd71019613edff6d88b893
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteoblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 TENM3 PAMR1 VIT

1.64e-04194634811b382ec3da06a6bda7360abc8b633f96b2019e
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 TENM3 PAMR1 VIT

1.64e-04194634292ce9021678534c9eedb367b9772a9d976208a8
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.67e-04195634803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.67e-04195634cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCellfacs-Brain_Myeloid-Hippocampus|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKAB1 NAV3 HERC2 FSCN1

1.67e-04195634a1478021a3ed0e779716393124ca2a7770c433b7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.67e-04195634783bfa8110161cbd6def50ce849cae676c39c458
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPD2 PCSK2 RPS6KA2 KLHL32

1.67e-041956343e519cffa6144a62b06124642a14c9ff39b76554
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.67e-041956344f70157d42a16ff0259bc24a62803c4df4285c44
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPD2 PCSK2 RPS6KA2 KLHL32

1.67e-041956347796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB2 ATP6V0B SLC39A6 SLC25A29

1.67e-041956340ac7762197cdd8d643f87148573a8df6e936c1b0
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 TENM3 NAV3 ABCC9

1.70e-041966346bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FKBP10 TENM3 PAMR1 NAV3

1.70e-04196634525d6c8a277364e624e7cc586275f8a891436b57
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.70e-04196634a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 TENM3 NAV3 ABCC9

1.70e-04196634c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellControl-Stromal-Fibroblast|Control / Disease state, Lineage and Cell class

FKBP10 PAMR1 NAV3 VIT

1.70e-041966347ca94477498a84cafcdd9933ee92a6cbde76c70e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB2 ATP6V0B SLC39A6 SLC25A29

1.70e-04196634cd8c22c6f52f068a33525723108d6b5b23fe822d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.70e-041966343e6803587d8566fd08cb8b290be3b6461743d79c
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|COVID-19_Mild / Disease condition and Cell class

PLBD1 IGF2R HPSE PGD

1.70e-04196634f245e929a286cb097130572e1027b4f01be8b04d
ToppCelldroplet-Heart-HEART|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 IRS1 FSCN1 NNT

1.74e-041976349654472f1d4c9a6caadf1ff61a84902d171e9eb4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.74e-041976346d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.74e-04197634b349f8e96d61a4c296af64711e11fc44459a9413
ToppCelldroplet-Heart-HEART-1m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 IRS1 FSCN1 NNT

1.74e-041976341ec3c05a5d4163df2cf0d168e28a3f1d35364da2
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 TENM3 PAMR1 ABCC9

1.74e-04197634c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 TENM3 PAMR1 VIT

1.77e-041986341f956e369e00d37835095a001db4b62a79014532
ToppCell5'-Adult-SmallIntestine-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MALRD1 REG1A SLC5A12 BAIAP2L2

1.77e-041986348d629492d2199de8e036c19e9dacceb9c9e721a0
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FKBP10 TENM3 PAMR1 VIT

1.77e-04198634dc6fbad0ecdd057189f71afcdb6aca25207314a3
ToppCellCOVID-19-kidney-Fibroblast-2|kidney / Disease (COVID-19 only), tissue and cell type

FKBP10 TENM3 NAV3 ABCC9

1.77e-04198634ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MALRD1 REG1A SLC5A12 BAIAP2L2

1.77e-041986346e6af8fad09f8e48b3f2ce463d5773b6a69864d1
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-OPC_related-OPC|GW12 / Sample Type, Dataset, Time_group, and Cell type.

SUOX CDHR1 DGKG EYA1

1.80e-04199634c0dc14fb9899d4263264347436de121814441dfb
ToppCell5'-Adult-SmallIntestine|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MALRD1 REG1A SLC5A12 BAIAP2L2

1.80e-04199634a5fffe381be1ba7d192b68d1d3937ce47663658e
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FKBP10 PAMR1 NAV3 VIT

1.80e-04199634f835e7ffe976843b0edbf695762d463da85793f3
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FKBP10 TENM3 PAMR1 NAV3

1.80e-0419963483383d9ae4f501754fd3da0215ce6f0e3c70562c
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FKBP10 NAV3 ABCC9 HPSE

1.80e-04199634eeb7d370d4dfacf705306c72ccc4919ddefacff1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FKBP10 PAMR1 NAV3 VIT

1.80e-04199634993fa050a095017135a6e723c77cd38b9d782e58
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW12-OPC_related|GW12 / Sample Type, Dataset, Time_group, and Cell type.

SUOX CDHR1 DGKG EYA1

1.80e-041996349bc53ff93ca97af4ee0f01c74a567987a26abb18
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MALRD1 REG1A SLC5A12 BAIAP2L2

1.80e-0419963401c2721bc82cd672e9477029b4a7ecc77e2f1b00
ToppCellBiopsy_Other_PF-Mesenchymal-Fibroblasts|Biopsy_Other_PF / Sample group, Lineage and Cell type

FKBP10 PAMR1 ABCC9 VIT

1.84e-042006349996b6887cf2b1936e10a1aa396f09fd8da5f4c4
ToppCell367C-Fibroblasts-Fibroblast-E-|367C / Donor, Lineage, Cell class and subclass (all cells)

FKBP10 PAMR1 ABCC9 VIT

1.84e-0420063457b9d6aa2265ab178a5886f36ecc66115bd382a8
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

KCNQ4 RPS6KA2 DGKG ABCC9

1.84e-04200634cf883ba5dbe6350b93142d625a52b25ff2a8bb63
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

FKBP10 PAMR1 ABCC9 IRS1

1.84e-042006345ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellParenchymal-10x3prime_v2-Stromal-Peri/Epineurial_|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGHV3-53 FKBP10 PAMR1 VIT

1.84e-042006345ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCellsevere-immature_Neutrophil|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PLBD1 UBE2C DGKG PGD

1.84e-04200634a9b87accdaa6956116ab82427e1330e8f007ef94
ToppCell367C-Fibroblasts-Fibroblast-E|367C / Donor, Lineage, Cell class and subclass (all cells)

FKBP10 PAMR1 ABCC9 VIT

1.84e-04200634ddfbc004e7bd2fd3f11f046ed8fc049277160547
Drug2-amino-4-methylthio-3-butenoic acid

MAT1A MAT2A

7.06e-062612ctd:C083253
DrugUrsolic acid [77-52-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A

GPD2 FKBP10 ERBB2 EML2 PPIL2 DCTN1

1.41e-051966167181_DN
DrugNialamide [51-12-7]; Down 200; 13.4uM; PC3; HT_HG-U133A

GPD2 FKBP10 NAV3 EML2 PPIL2 NPEPL1

1.58e-052006164525_DN
DrugL-2-amino-4-methylthio-cis-but-3-enoic acid

MAT1A MAT2A

2.11e-053612CID006439623
Drugbenzylphosphate

MAT1A MAT2A

2.11e-053612CID000074359
Drugoctadecylphosphonic acid

FEZF2 MAT1A

2.11e-053612CID000078451
DrugAC1L1I1P

DNAAF10 MAT1A MAT2A EYA1

2.32e-0562614CID000004385
Drugarabinosyladenine

GPD2 IGF2R MAT1A MAT2A PRKAB1 ABCC9 REG1A F2 NNT PGD

3.20e-057626110CID000000191
DrugNSC226080

FKBP10 ERBB2 IGF2R DNAAF10 RPS6KA2 EIF4B PRKAB1 PPIL2 IRS1 F2

3.98e-057826110CID000005040
DrugNSC-187732

MAT1A MAT2A

4.22e-054612CID000302526
Drugvinthionine

MAT1A MAT2A

4.22e-054612CID000055145
Drugseleno-DL-ethionine

MAT1A MAT2A

4.22e-054612CID000145924
DiseaseLiver carcinoma

IGF2R PAMR1 MAT1A UBE2C IRS1 F2 HPSE PGD

1.22e-05507638C2239176
DiseaseAsthma, Occupational

TENM3 HERC2

2.00e-0410632C0264423
DiseaseNephrosis

F2 HPSE

4.63e-0415632C0027720
Diseaselipid metabolism disorder (implicated_via_orthology)

MAT1A MAT2A

4.63e-0415632DOID:3146 (implicated_via_orthology)
Diseasetype 2 diabetes mellitus (is_implicated_in)

GPD2 PCSK2 IGF2R IRS1

4.97e-04171634DOID:9352 (is_implicated_in)
DiseaseAmyotrophic lateral sclerosis

ALS2 DCTN1

5.98e-0417632cv:C0002736
DiseaseChild Behaviour Checklist assessment

PCSK2 TENM3

6.71e-0418632EFO_0005661
Diseaseend stage renal disease (implicated_via_orthology)

IRS1 F2

8.32e-0420632DOID:783 (implicated_via_orthology)
Diseasecolorectal health

LIG4 PAMR1 HERC2 MAP3K19

9.09e-04201634EFO_0008460
DiseaseDiabetes Mellitus, Non-Insulin-Dependent

GPD2 PCSK2 MAT1A IRS1

1.29e-03221634C0011860
DiseaseStreptozotocin Diabetes

GPD2 PCSK2 IRS1

1.61e-03108633C0038433
DiseaseDiabetes Mellitus, Experimental

GPD2 PCSK2 IRS1

1.61e-03108633C0011853
DiseaseAlloxan Diabetes

GPD2 PCSK2 IRS1

1.61e-03108633C0002152
DiseaseTYPE 2 DIABETES MELLITUS

GPD2 IRS1

1.64e-0328632125853
DiseaseType 2 diabetes mellitus

GPD2 IRS1

1.64e-0328632cv:C0011860
Diseaseglucose metabolism disease (implicated_via_orthology)

DGKG IRS1

1.64e-0328632DOID:4194 (implicated_via_orthology)
Diseaselung carcinoma, family history of lung cancer

PCSK2 MALRD1

1.76e-0329632EFO_0001071, EFO_0006953

Protein segments in the cluster

PeptideGeneStartEntry
LGSGAFGTVYKGIWI

ERBB2

726

P04626
TGPWGEVKYSTYGTG

CDHR1

501

Q96JP9
YVGATLFATGKWVGV

DCTN1

46

Q14203
EGYFSGEWGSGIKIT

ALS2

1246

Q96Q42
KGTGKWTAISALEYG

PGD

261

P52209
AIKVTNGYFSWGSGL

ABCC9

671

O60706
IATRITGGWKSGTEY

ANKRD36

1246

A6QL64
EYSWSLGCGVGAGLI

CACNG6

216

Q9BXT2
WTGGVYLVAGKLFGL

RAI1

1831

Q7Z5J4
TGTGTGGESYWGKPF

PPIL2

336

Q13356
ATRITGGWKSGTEYP

ANKRD36C

1111

Q5JPF3
ESGLITIAGGKWTTY

GPD2

426

P43304
TSEVYVWGGGKSTPQ

NEK9

346

Q8TD19
ALTKSGAVYTWGKGD

HERC2

4211

O95714
LTGRKIIVDTYGGWG

MAT2A

261

P31153
GGTWKLLGSVVYAHS

KCNQ4

221

P56696
WGTITLTTIGYGDKT

KCNQ4

276

P56696
GKGSGSGWYLDRVLV

LOXHD1

626

Q8IVV2
NGWLYGKLEGSSASG

BAIAP2L2

361

Q6UXY1
LTAGGAGGLHLWKYE

DNAAF10

276

Q96MX6
GKGLEWVSYISSSGS

IGHV3-48

61

P01763
AWVGKGIVYDTGGLS

NPEPL1

256

Q8NDH3
AYLIGSIGVSGKTKW

NAV3

1936

Q8IVL0
ISSYGALWAGIKTEG

EYA1

136

Q99502
VTGRKIIVDTYGGWG

MAT1A

261

Q00266
GGIGGTILYAKWDSH

IMMT

56

Q16891
GWFGKVLLGEIYTGT

LMTK2

146

Q8IWU2
SGTSYGKLWTNGVGG

IRS1

691

P35568
GKKVWLGETSSAYGG

HPSE

336

Q9Y251
TTGWGILEIRAGYGS

PLBD1

76

Q6P4A8
WTLVYGTGKHGTSLK

OXR1

736

Q8N573
SVIGNKRTGWTYGSV

MALRD1

1841

Q5VYJ5
WGGGYEGGSLTKILK

DGKG

531

P49619
SKGGTYDTYVGSGWL

FKBP10

196

Q96AY3
ELDILIVGGYWGKGS

LIG4

461

P49917
TGKYWTLTATGGVQS

FSCN1

311

Q16658
GGTSGIVSWLSTYPV

SLC25A29

196

Q8N8R3
VVTGDSGGNLYVWGK

EML2

266

O95834
GGFGYVVGGIHWDKT

SLC45A1

276

Q9Y2W3
WTKGEILGKGAYGTV

MAP3K19

1061

Q56UN5
ITLKGWTGYRGGLDT

GARNL3

241

Q5VVW2
YSELWKSSLRAGGGG

FEZF2

91

Q8TBJ5
NGSWGGTLDDFYVKG

PAMR1

96

Q6UXH9
GSLVSYKSWGIGAPS

REG1A

116

P05451
GKGLEWVSVIYSGGS

IGHV3-53

61

P01767
GTGGGSTYVSKPVSW

EIF4B

26

P23588
GLAGIVGYHTVWGVT

NNT

506

Q13423
SSLAKSEGGLGGNWY

IGF2R

781

P11717
KGSSELLWGGVPQYS

TNRC6C

1641

Q9HCJ0
VGSWMIYEGEGSGLI

MT-ND6

121

P03923
GGLGSTDPTGKAAYW

ERVK-9

766

P63128
AYFDSTWKGLTALGG

SLC39A6

416

Q13433
VFRWTGGGKEVYLSG

PRKAB1

81

Q9Y478
LSIWYDVGGIIGGTL

SLC37A3

331

Q8NCC5
SVVGAAWGIYITGSS

ATP6V0B

61

Q99437
AWGIYITGSSIIGGG

ATP6V0B

66

Q99437
SKYGQGAGEGSTREW

TNKS1BP1

776

Q9C0C2
AIKRVGYWSGGTSTG

VIT

561

Q6UXI7
GLLTRVYSKGSGWTV

TENM3

2211

Q9P273
SLLQAGYKGRVTGWG

F2

491

P00734
GEVTIKGYAWSGGGR

SUOX

441

P51687
ITVGGTFTWLGIYGV

SLC5A12

241

Q1EHB4
KWVGTIHGAAGTVYE

UBE2C

61

O00762
VKAEAGGGWEGSASY

WBP2

96

Q969T9
GGGWEGSASYKLTFT

WBP2

101

Q969T9
GYVADGLLWISGGVT

KLHL32

441

Q96NJ5
IGSGKYALSGGNWDS

RPS6KA2

626

Q15349
AWELGYTGKGVTIGI

PCSK2

151

P16519
GRGGKGSIYVWASGD

PCSK2

296

P16519