Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3S28 kinase activity	RPS6KA4 RPS6KA5	3.84e-05	3	72	2	GO:0044022
GeneOntologyMolecularFunction	histone H3S10 kinase activity	RPS6KA4 RPS6KA5	7.66e-05	4	72	2	GO:0035175
GeneOntologyMolecularFunction	histone modifying activity	RPS6KA4 SETD1B RPS6KA5 KDM4C SUV39H1 KAT6A	1.77e-04	229	72	6	GO:0140993
GeneOntologyMolecularFunction	transcription factor binding	CDC37 TEAD2 LATS1 KDM4C KAT6A SOX8 TEAD3 SIX3 CNOT1 NLRP3	3.55e-04	753	72	10	GO:0008134
GeneOntologyCellularComponent	TEAD-YAP complex	TEAD2 TEAD1	3.50e-05	3	72	2	GO:0140552
Domain	TEA_1	TEAD2 TEAD1 TEAD3	2.01e-07	4	70	3	PS00554
Domain	TEA	TEAD2 TEAD1 TEAD3	2.01e-07	4	70	3	SM00426
Domain	TEA_2	TEAD2 TEAD1 TEAD3	2.01e-07	4	70	3	PS51088
Domain	TEA	TEAD2 TEAD1 TEAD3	2.01e-07	4	70	3	PF01285
Domain	TEA/ATTS_dom	TEAD2 TEAD1 TEAD3	2.01e-07	4	70	3	IPR000818
Domain	TEF_metazoa	TEAD2 TEAD1 TEAD3	2.01e-07	4	70	3	IPR016361
Domain	Pkinase_C	LATS1 RPS6KA4 RPS6KA5 PRKCZ	1.09e-05	37	70	4	IPR017892
Domain	Pkinase_C	LATS1 RPS6KA4 RPS6KA5 PRKCZ	1.82e-05	42	70	4	PF00433
Domain	BMP_1/tolloid-like	TLL1 TLL2	4.14e-05	3	70	2	IPR015446
Domain	AGC-kinase_C	LATS1 RPS6KA4 RPS6KA5 PRKCZ	5.74e-05	56	70	4	IPR000961
Domain	AGC_KINASE_CTER	LATS1 RPS6KA4 RPS6KA5 PRKCZ	5.74e-05	56	70	4	PS51285
Domain	S_TK_X	LATS1 RPS6KA4 RPS6KA5 PRKCZ	5.74e-05	56	70	4	SM00133
Domain	LCCL	COCH VIT	2.06e-04	6	70	2	PS50820
Domain	Peptidase_M12A	TLL1 TLL2	2.06e-04	6	70	2	IPR001506
Domain	LCCL	COCH VIT	2.06e-04	6	70	2	SM00603
Domain	LCCL	COCH VIT	2.06e-04	6	70	2	PF03815
Domain	Astacin	TLL1 TLL2	2.06e-04	6	70	2	PF01400
Domain	LCCL	COCH VIT	2.06e-04	6	70	2	IPR004043
Domain	-	COCH VIT	2.06e-04	6	70	2	2.170.130.20
Domain	Ribosomal_S6_kinase_II	RPS6KA4 RPS6KA5	2.06e-04	6	70	2	IPR016239
Domain	Post-SET_dom	SETD1B SUV39H1	1.61e-03	16	70	2	IPR003616
Domain	PostSET	SETD1B SUV39H1	1.61e-03	16	70	2	SM00508
Domain	POST_SET	SETD1B SUV39H1	1.61e-03	16	70	2	PS50868
Domain	-	COCH MDN1 VIT	2.70e-03	74	70	3	3.40.50.410
Domain	EPHD	KDM4C PHF7	3.05e-03	22	70	2	PS51805
Domain	VWFA	COCH MDN1 VIT	3.61e-03	82	70	3	PS50234
Domain	Chromo_domain	SUV39H1 CHD9	3.62e-03	24	70	2	IPR023780
Domain	VWA	COCH MDN1 VIT	3.87e-03	84	70	3	SM00327
Domain	Kinase-like_dom	PTK2B PTPN13 LATS1 RPS6KA4 RPS6KA5 CHD9 PRKCZ	4.12e-03	542	70	7	IPR011009
Domain	EGF_CA	CD93 TLL1 TLL2	4.13e-03	86	70	3	PF07645
Domain	Chromo	SUV39H1 CHD9	4.25e-03	26	70	2	PF00385
Domain	PHD	KDM4C KAT6A PHF7	4.55e-03	89	70	3	SM00249
Domain	Znf_PHD	KDM4C KAT6A PHF7	4.84e-03	91	70	3	IPR001965
Domain	CHROMO_1	SUV39H1 CHD9	4.91e-03	28	70	2	PS00598
Domain	CHROMO_2	SUV39H1 CHD9	4.91e-03	28	70	2	PS50013
Domain	ZnMc	TLL1 TLL2	5.27e-03	29	70	2	SM00235
Domain	Peptidase_Metallo	TLL1 TLL2	5.27e-03	29	70	2	IPR006026
Domain	ZF_PHD_2	KDM4C KAT6A PHF7	5.46e-03	95	70	3	PS50016
Domain	ZF_PHD_1	KDM4C KAT6A PHF7	5.62e-03	96	70	3	PS01359
Domain	EGF_Ca-bd_CS	CD93 TLL1 TLL2	5.78e-03	97	70	3	IPR018097
Domain	EGF_CA	CD93 TLL1 TLL2	6.12e-03	99	70	3	PS01187
Domain	VWF_A	COCH MDN1 VIT	6.12e-03	99	70	3	IPR002035
Domain	JMJC	KDM4C TYW5	6.39e-03	32	70	2	PS51184
Domain	Chromodomain-like	SUV39H1 CHD9	6.39e-03	32	70	2	IPR016197
Domain	JmjC_dom	KDM4C TYW5	6.39e-03	32	70	2	IPR003347
Domain	JmjC	KDM4C TYW5	6.78e-03	33	70	2	SM00558
Domain	Chromo/shadow_dom	SUV39H1 CHD9	6.78e-03	33	70	2	IPR000953
Pathway	WP_TRANSCRIPTION_COFACTORS_SKI_AND_SKIL_PROTEIN_PARTNERS	TEAD2 LATS1 TEAD1 TEAD3	4.85e-07	18	52	4	M39825
Pathway	REACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION	TEAD2 TEAD1 TEAD3	9.39e-07	6	52	3	MM15544
Pathway	WP_HIPPOYAP_SIGNALING	TEAD2 LATS1 TEAD1 TEAD3	1.15e-06	22	52	4	M39821
Pathway	REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	TEAD2 TEAD1 TEAD3	2.62e-06	8	52	3	MM14816
Pathway	REACTOME_RUNX3_REGULATES_YAP1_MEDIATED_TRANSCRIPTION	TEAD2 TEAD1 TEAD3	2.62e-06	8	52	3	M27823
Pathway	WP_LEUKOCYTEINTRINSIC_HIPPO_PATHWAY_FUNCTIONS	TEAD2 LATS1 TEAD1 TEAD3	7.92e-06	35	52	4	M39430
Pathway	REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	TEAD2 TEAD1 TEAD3	2.09e-05	15	52	3	M603
Pathway	WP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS	TEAD2 LATS1 TEAD1 TEAD3	2.61e-05	47	52	4	M39829
Pathway	WP_HIPPO_SIGNALING_REGULATION	TEAD2 LATS1 PRKCZ TEAD1 TEAD3	2.94e-05	98	52	5	M39830
Pathway	WP_MIR5093P_ALTERATION_OF_YAP1ECM_AXIS	TEAD2 TEAD1 TEAD3	3.71e-05	18	52	3	M39421
Pathway	KEGG_MEDICUS_REFERENCE_TNF_P38_SIGNALING_PATHWAY	TRAF2 RPS6KA4 RPS6KA5	9.07e-05	24	52	3	M47568
Pubmed	Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis.	TEAD2 TEAD1 TEAD3	3.69e-08	4	74	3	9889009
Pubmed	The TEA domain: a novel, highly conserved DNA-binding motif.	TEAD2 TEAD1 TEAD3	3.69e-08	4	74	3	2070413
Pubmed	A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.	TEAD2 TEAD1 TEAD3	3.69e-08	4	74	3	8702974
Pubmed	Tead transcription factors differentially regulate cortical development.	TEAD2 TEAD1 TEAD3	3.69e-08	4	74	3	32170161
Pubmed	Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.	TEAD2 TEAD1 TEAD3	3.69e-08	4	74	3	36516960
Pubmed	Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse.	TEAD2 TEAD1 TEAD3	3.69e-08	4	74	3	9169843
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	PTK2B TRAF2 LATS1 RPS6KA4 SETD1B GALNT1 RPS6KA5 TRPM3 SUV39H1 KAT6A PRKCZ PSPC1	4.47e-08	730	74	12	34857952
Pubmed	TEAD mediates YAP-dependent gene induction and growth control.	TEAD2 TEAD1 TEAD3	9.22e-08	5	74	3	18579750
Pubmed	TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.	TEAD2 TEAD1 TEAD3	9.22e-08	5	74	3	10518497
Pubmed	Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro.	TEAD2 TEAD1 TEAD3	9.22e-08	5	74	3	9671946
Pubmed	Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments.	TEAD2 TEAD1 TEAD3	9.22e-08	5	74	3	21527258
Pubmed	TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.	TEAD2 TEAD1 TEAD3	9.22e-08	5	74	3	19324877
Pubmed	Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.	TEAD2 TEAD1 TEAD3	9.22e-08	5	74	3	22677547
Pubmed	Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.	TEAD2 PRKCZ TEAD1 TEAD3	1.62e-07	23	74	4	18083014
Pubmed	Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.	TEAD2 TEAD1 TEAD3	1.84e-07	6	74	3	25995450
Pubmed	TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.	TEAD2 TEAD1 TEAD3	1.84e-07	6	74	3	11358867
Pubmed	Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3.	TEAD2 TEAD1 TEAD3	3.22e-07	7	74	3	14736747
Pubmed	Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor.	TEAD2 TEAD1 TEAD3	3.22e-07	7	74	3	16207754
Pubmed	RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.	TRAF2 RPS6KA4 RPS6KA5	7.70e-07	9	74	3	19224920
Pubmed	AMPK modulates Hippo pathway activity to regulate energy homeostasis.	TEAD2 LATS1 TEAD1	1.10e-06	10	74	3	25751139
Pubmed	Expression pattern of transcriptional enhanced associate domain family member 1 (Tead1) in developing mouse molar tooth.	TEAD2 TEAD1 TEAD3	2.60e-06	13	74	3	33984529
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	TRAF2 COCH GALNT1 SMOC1 SNAP47 CNOT1 KIF7	3.80e-06	302	74	7	30561431
Pubmed	Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	36812480
Pubmed	Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	21314333
Pubmed	The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	21166721
Pubmed	Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	25451279
Pubmed	Characterization of the cellular action of the MSK inhibitor SB-747651A.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	21970321
Pubmed	Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	23127194
Pubmed	p38{alpha} MAP kinase controls IL-17 synthesis in vogt-koyanagi-harada syndrome and experimental autoimmune uveitis.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	20164464
Pubmed	RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation.	ARHGDIG NLRP3	4.47e-06	2	74	2	38029612
Pubmed	The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	18513320
Pubmed	The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	27973548
Pubmed	MSK activation and physiological roles.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	18508628
Pubmed	A role of mitogen and stress-activated protein kinase 1/2 in survival of lipopolysaccharide-stimulated RAW 264.7 macrophages.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	15681159
Pubmed	PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury.	TRAF2 PRKCZ	4.47e-06	2	74	2	28726782
Pubmed	Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	15128846
Pubmed	Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	23020821
Pubmed	Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	26611568
Pubmed	TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human Epidermal Proliferation.	TEAD1 TEAD3	4.47e-06	2	74	2	32142794
Pubmed	Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction.	RPS6KA4 RPS6KA5	4.47e-06	2	74	2	34445361
Pubmed	Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.	TLL1 TLL2	4.47e-06	2	74	2	11313359
Pubmed	New nomenclature for chromatin-modifying enzymes.	SETD1B KDM4C SUV39H1 KAT6A	6.85e-06	57	74	4	18022353
Pubmed	PRAMEF2-mediated dynamic regulation of YAP signaling promotes tumorigenesis.	LATS1 SUV39H1 TEAD1	8.74e-06	19	74	3	34593639
Pubmed	Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.	TEAD2 TEAD1 TEAD3	8.74e-06	19	74	3	20596238
Pubmed	Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.	TEAD2 TEAD1 TEAD3	1.03e-05	20	74	3	18978355
Pubmed	Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	19933278
Pubmed	Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.	SUV39H1 WRN	1.34e-05	3	74	2	25931448
Pubmed	RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	23719381
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	TLL1 TLL2	1.34e-05	3	74	2	18824173
Pubmed	Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	24792438
Pubmed	Differential regulation of the phosphorylation of Trimethyl-lysine27 histone H3 at serine 28 in distinct populations of striatal projection neurons.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	26947946
Pubmed	PGC-1α inhibits NLRP3 signaling through transcriptional activation of POP1 to alleviate inflammation and strengthen osteogenic differentiation of lipopolysaccharide-induced human periodontal stem cells.	POP1 NLRP3	1.34e-05	3	74	2	38763227
Pubmed	Functional interaction between the p160 coactivator proteins and the transcriptional enhancer factor family of transcription factors.	TEAD2 TEAD1	1.34e-05	3	74	2	10934189
Pubmed	CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	24438093
Pubmed	Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19.	TLL1 TLL2	1.34e-05	3	74	2	10516436
Pubmed	Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc.	TEAD2 TEAD1	1.34e-05	3	74	2	25588835
Pubmed	Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	23675462
Pubmed	Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	20864036
Pubmed	A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns.	TEAD1 TEAD3	1.34e-05	3	74	2	8920920
Pubmed	MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	28593137
Pubmed	MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	17668895
Pubmed	Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	17495961
Pubmed	Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection.	RPS6KA4 RPS6KA5	1.34e-05	3	74	2	26109721
Pubmed	IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation.	IFNGR1 FOXN1	1.34e-05	3	74	2	17173138
Pubmed	Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.	LATS1 TEAD1 TEAD3	1.59e-05	23	74	3	26933062
Pubmed	The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation.	RPS6KA4 RPS6KA5	2.67e-05	4	74	2	16517600
Pubmed	GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.	IFNGR1 NLRP3	2.67e-05	4	74	2	22461501
Pubmed	YAP/TEAD-mediated transcription controls cellular senescence.	TEAD1 TEAD3	2.67e-05	4	74	2	23576552
Pubmed	The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation.	RPS6KA4 RPS6KA5	2.67e-05	4	74	2	24519526
Pubmed	MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.	RPS6KA4 RPS6KA5	2.67e-05	4	74	2	11909979
Pubmed	Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.	RPS6KA4 RPS6KA5	2.67e-05	4	74	2	25233930
Pubmed	Mammalian tolloid proteinases: role in growth factor signalling.	TLL1 TLL2	2.67e-05	4	74	2	27391803
Pubmed	A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells.	LATS1 TEAD1	2.67e-05	4	74	2	27886176
Pubmed	VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.	TEAD1 TEAD3	2.67e-05	4	74	2	31138678
Pubmed	Why T cells of thymic versus extrathymic origin are functionally different.	IFNGR1 FOXN1	2.67e-05	4	74	2	18250439
Pubmed	The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.	POP1 NLRP3	2.67e-05	4	74	2	26275995
Pubmed	Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways.	RPS6KA4 RPS6KA5	2.67e-05	4	74	2	27795299
Pubmed	cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the TEA/ATTS family of transcription factors.	TEAD2 TEAD3	2.67e-05	4	74	2	9502435
Pubmed	Mechanosignalling via integrins directs fate decisions of pancreatic progenitors.	TEAD2 TEAD1 TEAD3	4.39e-05	32	74	3	30487608
Pubmed	Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers.	RPS6KA4 RPS6KA5	4.45e-05	5	74	2	23533666
Pubmed	MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop.	RPS6KA4 RPS6KA5	4.45e-05	5	74	2	23382072
Pubmed	Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins.	RPS6KA4 RPS6KA5	4.45e-05	5	74	2	20307261
Pubmed	The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways.	RPS6KA4 RPS6KA5	4.45e-05	5	74	2	17906627
Pubmed	Genomic structure and chromosomal mapping of the mouse transcription factor TEF-5 (Tead3) gene.	TEAD2 TEAD3	4.45e-05	5	74	2	10341100
Pubmed	The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling.	RPS6KA4 RPS6KA5	4.45e-05	5	74	2	18690222
Pubmed	Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.	KDM4C SUV39H1	4.45e-05	5	74	2	29077881
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	TLL1 TLL2	4.45e-05	5	74	2	10479448
Pubmed	miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity.	RPS6KA4 RPS6KA5	4.45e-05	5	74	2	23658634
Pubmed	MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages.	RPS6KA4 RPS6KA5	4.45e-05	5	74	2	19922413
Pubmed	The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.	TEAD1 TEAD3	4.45e-05	5	74	2	20516196
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	TEAD2 PNPLA6 RBMS2 TEAD1 TEAD3 PSPC1 CNOT1	5.45e-05	457	74	7	32344865
Pubmed	Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells.	FOXN1 SOX8	6.66e-05	6	74	2	35714609
Pubmed	Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.	LATS1 TEAD1 TEAD3	8.63e-05	40	74	3	30865227
Pubmed	PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.	RPS6KA4 RPS6KA5	9.31e-05	7	74	2	23241891
Pubmed	Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling.	FOXN1 LATS1	9.31e-05	7	74	2	32960816
Pubmed	Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.	RPS6KA4 RPS6KA5	9.31e-05	7	74	2	20018936
Pubmed	Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.	RPS6KA4 C1orf141	9.31e-05	7	74	2	22019778
Pubmed	Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions.	TEAD1 TEAD3	9.31e-05	7	74	2	12861002
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	IFNGR1 PTPN13 LATS1 POP1 WRN HSD17B4	1.05e-04	351	74	6	20453000
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	MDN1 ZMIZ2 WRN CHD9 HSD17B4	1.14e-04	222	74	5	37071664
Interaction	HSP90AA4P interactions	CDC37 TEAD2 LATS1 RPS6KA4 RPS6KA5 SMOC1	2.47e-06	110	71	6	int:HSP90AA4P
GeneFamily	TEA domain transcription factors	TEAD2 TEAD1 TEAD3	7.47e-08	4	49	3	1183
GeneFamily	Bone morphogenetic proteins\|Astacins	TLL1 TLL2	1.07e-04	6	49	2	894
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	RPS6KA4 RPS6KA5	3.90e-04	11	49	2	1156
GeneFamily	RNA binding motif containing	SETD1B RBMS2 RBM24 PSPC1	2.62e-03	213	49	4	725
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B SUV39H1	3.82e-03	34	49	2	487
Coexpression	HAY_BONE_MARROW_STROMAL	TEAD2 MXRA5 PTPN13 TLL1 ARHGAP28 ZNF488 TEAD1 TEAD3 SMOC1 GASK1A KIF7	9.79e-06	767	74	11	M39209
ToppCell	Mild-MAIT\|Mild / Disease group and Cell class	IFNGR1 TEAD2 PTPN13 CTIF TEAD3	7.28e-06	161	74	5	0c1a04485708d5302600cdc2d7dac1cb76b4033a
ToppCell	Thalamus-Endothelial\|Thalamus / BrainAtlas - Mouse McCarroll V32	MUSTN1 CD93 TEAD2 RBMS2 DYSF	1.46e-05	186	74	5	dcc6e4417c4123d5ca6b96fa8ca4874626aaebdb
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 TEAD3 RBM24 SMOC1 ZNF365	1.54e-05	188	74	5	61f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCell	droplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUSTN1 TEAD3 RBM24 SMOC1 ZNF365	1.54e-05	188	74	5	7553ef7de3575af4cf34704b405b551c1af8eb83
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COCH PRKCZ SOX8 SIX3 ZNF365	1.75e-05	193	74	5	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CD93 RBMS2 TLL1 ARHGAP28 DYSF	1.75e-05	193	74	5	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COCH PRKCZ SOX8 SIX3 ZNF365	1.79e-05	194	74	5	ba529c051f248d29f4222f4bc9801ba233859093
ToppCell	facs-Brain_Non-Myeloid-Hippocampus\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT1 ZNF488 SOX8 SMOC1 HSD17B4	2.07e-05	200	74	5	fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-BMP_responsible_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	TEAD2 TRPM3 SMOC1 SIX3 PLEKHD1	2.07e-05	200	74	5	ce8a3a8367bafdfabc7c2f96b003aa99526a54e4
Disease	volumetric bone mineral density	FOXN1 PTK2B CTIF	1.56e-04	42	73	3	EFO_0007620
Disease	holoprosencephaly (is_implicated_in)	SIX3 CNOT1	1.67e-04	8	73	2	DOID:4621 (is_implicated_in)
Disease	disorder of pharynx	FOXN1 CARMIL2 DYSF	2.04e-04	46	73	3	MONDO_0020592
Disease	microphthalmia (implicated_via_orthology)	TRPM3 RBM24	3.92e-04	12	73	2	DOID:10629 (implicated_via_orthology)
Disease	Takayasu arteritis	PTK2B TRANK1 TLL2 GADL1	5.06e-04	148	73	4	EFO_1001857
Disease	breast cancer (is_implicated_in)	PTK2B PTPN13 KDM4C WRN	5.32e-04	150	73	4	DOID:1612 (is_implicated_in)
Disease	Crohn's disease	CDC37 PTK2B RPS6KA4 TRPM3 CTIF C1orf141	7.88e-04	441	73	6	EFO_0000384
Disease	DiGeorge syndrome (implicated_via_orthology)	FOXN1 KAT6A	1.00e-03	19	73	2	DOID:11198 (implicated_via_orthology)
Disease	vasculitis	PTK2B KDM4C	1.61e-03	24	73	2	EFO_0006803
Disease	leprosy	RPS6KA4 VIT C1orf141	2.15e-03	103	73	3	EFO_0001054
Disease	S-6-hydroxywarfarin measurement	GALNT1 FGFBP3 CHD9 SOX8 DYSF	2.20e-03	368	73	5	EFO_0803326

Protein segments in the cluster

Peptide	Gene	Start	Entry
KPRKPLDSVGLLEGD	C1orf141	121	Q5JVX7
PLPHIDREGCGKGKL	CTIF	136	O43310
KKGEGRQGLPCLEVP	BAIAP3	96	O94812
GCKLPPDALRALLDG	CARMIL2	471	Q6F5E8
GLQREKGKCLDPSLP	CD93	96	Q9NPY3
ILRPGGCLFLKEPVE	CIAPIN1	86	Q6FI81
EEERDRIPGPVCKGK	BRIX1	41	Q8TDN6
TPRIEKPDGKECLGR	LINC00313	56	P59037
GFRPELGDPVKVSCK	ATP1B4	256	Q9UN42
ERACKDPNPIIDGRK	RBM24	66	Q9BX46
DPLLCKFADGGPKKR	RBMS2	211	Q15434
RVPLDPLIGKNCDKG	NUBP1	266	P53384
CVGEKRKLIIPPALG	FKBP14	96	Q9NWM8
PPVKDEDLKGARGNL	MUSTN1	16	Q8IVN3
QDGLLELCLPGPDGK	PNPLA6	236	Q8IY17
DPAPLQARLCAGKKG	FGFBP3	126	Q8TAT2
LCLGRIDPKGSDIPE	MDN1	1566	Q9NU22
IKLCRGPEDRLGKNG	LATS1	986	O95835
GDVLRPPLAGCKAEL	PCNX3	511	Q9H6A9
GRKKACGEPTALPKD	FHIP2B	181	Q86V87
GSLPERKGPELCLEE	KIF7	656	Q2M1P5
IVSRDCLKLGPPAEG	KDM4C	926	Q9H3R0
LLCKDPKKRLGAGPQ	RPS6KA4	276	O75676
KDPKKRLGCGPRDAD	RPS6KA5	296	O75582
IKKIIGDGTRDPCLP	POP1	396	Q99575
GKPDLPKRRLSEGVE	KAT6A	931	Q92794
LCGLIKRPGDLPEVL	GASK1A	316	Q9UFP1
EKKERGLPAGDVLEP	GALNT1	36	Q10472
KVGGAFAPPLKDLCR	CHD9	2571	Q3L8U1
EFPTPKGKCIRVDGL	E2F2	101	Q14209
EPGEPEERKSLKLLG	COX20	6	Q5RI15
LCARVLLADKEGGPP	ARHGDIG	21	Q99819
EERKKRLGPGGLDPV	CDC37	281	Q16543
PLPRAGKLKCEAVVA	HSD17B4	416	P51659
DAPKDICSGLIGPLL	HEPHL1	191	Q6MZM0
CPDIKEKGLSGSPRL	GADL1	196	Q6ZQY3
GVLEKGDRLPKPDLC	PTK2B	636	Q14289
IRKEKADVLCPGGCP	COCH	41	O43405
LCVLGPGDEAPLERK	DYSF	341	O75923
VCRDGKIGPPKLDIR	IFNGR1	121	P15260
PADLDGCLKPGDRLI	PTPN13	1131	Q12923
KGCIPLPRGQTEKAD	NLRP3	36	Q96P20
CEPFGKEGILIKIPA	SNAP47	246	Q5SQN1
KSPLLGRFCGDKLPE	TLL1	416	O43897
KSPILGRLCGNKIPD	TLL1	841	O43897
CLREPGDPEKLGEFL	PHF7	36	Q9BWX1
GDKREKLGSPLLGCP	FOXN1	386	O15353
EAEKLRGRPLGPVDK	SIX3	176	O95343
PCELAKRDPKGVGVR	SETD1B	1006	Q9UPS6
PPCGRRKIILSDEGK	TEAD2	61	Q15562
KAGCPLDLERAGLTP	WRN	1296	Q14191
KPELKLEGRRPVDSG	SOX8	241	P57073
CRKGKGRLEEPLFPE	POM121L2	166	Q96KW2
AGLPGSPKKRVRIEC	SUV39H1	386	O43463
KRRCPSILGGLAPEK	CNOT1	621	A5YKK6
PLTCDGCGKKKIPRE	TRAF2	186	Q12933
DGKPLEVPERKAPLC	SLC17A6	46	Q9P2U8
PFKDRELPGCPEGKK	SMOC1	306	Q9H4F8
LSEPELGRGCKPVLL	ZNF488	36	Q96MN9
RDLCRPPKKGELLGF	ZNF365	371	Q70YC5
KPPARKALERCGDGA	PSPC1	206	Q8WXF1
KGVIPLGGCLVEPKE	PLEKHD1	81	A6NEE1
REDGKIIQLPPCKTG	TRPM3	1096	Q9HCF6
PLTVLLDGDRKKDPG	ARHGAP28	381	Q9P2N2
PPCGRRKIILSDEGK	TEAD3	51	Q99594
LLGRFCGDKIPEPLV	TLL2	421	Q9Y6L7
GKIIDPEFIVKCPAG	VIT	51	Q6UXI7
LLDPCFKGKIEAILP	ZBED10P	76	Q96FA7
IKEEPDGPALKRCRT	ZMIZ2	691	Q8NF64
PPCGRRKIILSDEGK	TEAD1	51	P28347
RKVSGEPPLGDCLIK	TRANK1	406	O15050
TKGELKAHPCLRPEG	ZNF579	241	Q8NAF0
QRKPLVLEGIDLGPC	TYW5	26	A2RUC4
GFLNKDPKERLGCRP	PRKCZ	491	Q05513
RKLIDCKAEGIPTPR	MXRA5	2461	Q9NR99