Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium:potassium:chloride symporter activity

SLC12A1 SLC12A2

5.28e-063272GO:0008511
GeneOntologyMolecularFunctionpotassium:sodium symporter activity

SLC12A1 SLC12A2

5.28e-063272GO:0009674
GeneOntologyMolecularFunctionphosphatidylcholine transfer activity

PITPNB PITPNA

2.63e-056272GO:0120019
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A1 SLC12A2

6.30e-059272GO:0015379
GeneOntologyMolecularFunctionphosphatidylinositol transfer activity

PITPNB PITPNA

9.61e-0511272GO:0008526
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC12A1 SLC12A2

2.36e-0417272GO:0015378
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC12A1 SLC12A2

2.97e-0419272GO:0015373
GeneOntologyMolecularFunctionphosphatidylcholine transporter activity

PITPNB PITPNA

3.30e-0420272GO:0008525
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A1 SLC12A2

4.38e-0423272GO:0015377
GeneOntologyMolecularFunctionphospholipid transfer activity

PITPNB PITPNA

5.61e-0426272GO:0120014
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A1 SLC12A2

5.61e-0426272GO:0015296
GeneOntologyMolecularFunctionphosphatidylcholine binding

PITPNB PITPNA

9.62e-0434272GO:0031210
GeneOntologyMolecularFunctionquaternary ammonium group binding

PITPNB PITPNA

1.76e-0346272GO:0050997
GeneOntologyMolecularFunctionlipid transporter activity

PITPNB ABCA13 PITPNA

2.29e-03196273GO:0005319
GeneOntologyMolecularFunctionlipid transfer activity

PITPNB PITPNA

2.68e-0357272GO:0120013
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

MARCHF4 HERC4 WWP1 WWP2

3.54e-03473274GO:0004842
GeneOntologyMolecularFunctionphospholipid transporter activity

PITPNB PITPNA

4.48e-0374272GO:0005548
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

MARCHF4 HERC4 WWP1 WWP2

4.69e-03512274GO:0019787
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC12A1 SLC12A2

5.34e-0381272GO:0015370
GeneOntologyMolecularFunctionaminoacyltransferase activity

MARCHF4 HERC4 WWP1 WWP2

5.37e-03532274GO:0016755
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A1 SLC12A2

1.12e-02119272GO:0015294
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC12A1 SLC12A2

1.23e-02125272GO:0015108
GeneOntologyCellularComponentmitotic spindle pole

MAPKBP1 KATNA1

1.30e-0343262GO:0097431
DomainE3_ub_ligase_SMURF1

WWP1 WWP2

1.72e-062252IPR024928
DomainNa/K/Cl_cotranspt

SLC12A1 SLC12A2

1.72e-062252IPR002443
DomainAA_permease_N

SLC12A1 SLC12A2

5.16e-063252PF08403
DomainAA_permease_N

SLC12A1 SLC12A2

5.16e-063252IPR013612
DomainHECT

HERC4 WWP1 WWP2

6.07e-0627253PF00632
DomainHECTc

HERC4 WWP1 WWP2

6.07e-0627253SM00119
DomainHECT_dom

HERC4 WWP1 WWP2

6.07e-0627253IPR000569
DomainHECT

HERC4 WWP1 WWP2

6.07e-0627253PS50237
DomainIP_trans

PITPNB PITPNA

1.72e-055252PF02121
DomainDUF3504

QRICH1 ZMYM4

1.72e-055252PF12012
DomainDUF3504

QRICH1 ZMYM4

1.72e-055252IPR021893
DomainPI_transfer

PITPNB PITPNA

2.57e-056252IPR001666
DomainSLC12A_fam

SLC12A1 SLC12A2

3.60e-057252IPR004842
DomainSLC12_C

SLC12A1 SLC12A2

4.79e-058252IPR018491
DomainSLC12

SLC12A1 SLC12A2

4.79e-058252PF03522
DomainAA-permease/SLC12A_dom

SLC12A1 SLC12A2

3.91e-0422252IPR004841
DomainAA_permease

SLC12A1 SLC12A2

3.91e-0422252PF00324
DomainSTART-like_dom

PITPNB PITPNA

4.28e-0423252IPR023393
Domain-

PITPNB PITPNA

4.28e-04232523.30.530.20
DomainAAA+_ATPase

KATNA1 DNAH10 ABCA13

9.12e-04144253IPR003593
DomainAAA

KATNA1 DNAH10 ABCA13

9.12e-04144253SM00382
DomainGPCR_2_secretin-like_CS

ADGRF5 CALCR

9.40e-0434252IPR017983
DomainG_PROTEIN_RECEP_F2_1

ADGRF5 CALCR

1.30e-0340252PS00649
DomainG_PROTEIN_RECEP_F2_3

ADGRF5 CALCR

1.30e-0340252PS50227
DomainGPCR_2_extracellular_dom

ADGRF5 CALCR

1.30e-0340252IPR001879
DomainC2_dom

OSBPL6 WWP1 WWP2

1.33e-03164253IPR000008
DomainWW

WWP1 WWP2

1.79e-0347252PF00397
DomainWW

WWP1 WWP2

1.87e-0348252SM00456
Domain7tm_2

ADGRF5 CALCR

2.03e-0350252PF00002
DomainG_PROTEIN_RECEP_F2_2

ADGRF5 CALCR

2.03e-0350252PS00650
DomainWW_DOMAIN_2

WWP1 WWP2

2.11e-0351252PS50020
DomainWW_DOMAIN_1

WWP1 WWP2

2.11e-0351252PS01159
DomainWW_dom

WWP1 WWP2

2.19e-0352252IPR001202
DomainGPCR_2-like

ADGRF5 CALCR

2.90e-0360252IPR017981
DomainGPCR_2_secretin-like

ADGRF5 CALCR

2.90e-0360252IPR000832
DomainG_PROTEIN_RECEP_F2_4

ADGRF5 CALCR

3.00e-0361252PS50261
DomainC2

WWP1 WWP2

1.32e-02131252PF00168
DomainC2

WWP1 WWP2

1.43e-02137252SM00239
DomainC2

WWP1 WWP2

1.54e-02142252PS50004
Domain-

WWP1 WWP2

1.66e-021482522.60.40.150
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A1 SLC12A2

2.53e-057162M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A1 SLC12A2

2.53e-057162MM15081
PathwayKEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS

HERC4 WWP1 WWP2

4.39e-04135163M15247
Pubmed

Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein beta.

PITPNB PITPNA

5.80e-0722728541325
Pubmed

Specific and nonspecific membrane-binding determinants cooperate in targeting phosphatidylinositol transfer protein beta-isoform to the mammalian trans-Golgi network.

PITPNB PITPNA

5.80e-07227216540520
Pubmed

Phospholipid transfer proteins.

PITPNB PITPNA

5.80e-0722721883207
Pubmed

Biological functions of phosphatidylinositol transfer proteins.

PITPNB PITPNA

5.80e-07227215052341
Pubmed

The Na-K-Cl cotransporters.

SLC12A1 SLC12A2

5.80e-0722729672238
Pubmed

Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells.

SLC12A1 SLC12A2

5.80e-0722727929272
Pubmed

Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms.

PITPNB PITPNA

5.80e-07227216274224
Pubmed

Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice.

SLC12A1 SLC12A2

5.80e-07227226400961
Pubmed

Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells.

PITPNB PITPNA

5.80e-07227218636990
Pubmed

Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells.

PITPNB PITPNA

5.80e-07227211907258
Pubmed

An isoform of the phosphatidylinositol-transfer protein transfers sphingomyelin and is associated with the Golgi system.

PITPNB PITPNA

5.80e-0722727654206
Pubmed

WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism.

WWP1 WWP2

5.80e-07227231965758
Pubmed

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2.

SLC12A1 SLC12A2

5.80e-0722728640224
Pubmed

Expression of the basolateral Na-K-Cl cotransporter during mouse nephrogenesis and embryonic development.

SLC12A1 SLC12A2

5.80e-07227216814616
Pubmed

Biochemical and biological functions of class I phosphatidylinositol transfer proteins.

PITPNB PITPNA

5.80e-07227217490911
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HERC4 WWP1 WWP2

1.07e-062627326949039
Pubmed

Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.

WWP1 WWP2

1.74e-06327212450395
Pubmed

Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.

SLC12A1 SLC12A2

1.74e-0632728663127
Pubmed

The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway.

PITPNB PITPNA

1.74e-06327218501717
Pubmed

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice.

PITPNB PITPNA

1.74e-06327230042096
Pubmed

Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia.

SLC12A1 SLC12A2

3.48e-06427220819979
Pubmed

Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta.

PITPNB PITPNA

3.48e-06427210531358
Pubmed

Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine.

PITPNB PITPNA

3.48e-06427211104777
Pubmed

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

SLC12A1 SLC12A2

3.48e-06427222989884
Pubmed

Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.

WWP1 WWP2

3.48e-06427226701932
Pubmed

Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.

SLC12A1 SLC12A2

3.48e-06427221972418
Pubmed

Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid.

PITPNB PITPNA

3.48e-06427222822086
Pubmed

A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis.

WWP1 WWP2

5.80e-06527210903445
Pubmed

A Tunable Brake for HECT Ubiquitin Ligases.

WWP1 WWP2

5.80e-06527228475870
Pubmed

Inhibition of HECT E3 ligases as potential therapy for COVID-19.

WWP1 WWP2

5.80e-06527233762578
Pubmed

Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases.

WWP1 WWP2

5.80e-06527219366705
Pubmed

Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140.

WWP1 WWP2

5.80e-06527230392800
Pubmed

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

WWP1 WWP2

8.69e-0662729647693
Pubmed

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.

WWP1 WWP2

1.22e-05727231845480
Pubmed

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.

WWP1 WWP2

1.62e-05827219307600
Pubmed

Similar effects of all WNK3 variants on SLC12 cotransporters.

SLC12A1 SLC12A2

1.62e-05827221613606
Pubmed

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).

SLC12A1 SLC12A2

1.62e-05827212386165
Pubmed

Cation-chloride cotransporters and neuronal function.

SLC12A1 SLC12A2

2.08e-05927219323993
Pubmed

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

WWP1 WWP2

2.60e-051027225092867
Pubmed

Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.

WWP1 WWP2

3.18e-051127217996703
Pubmed

Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.

WWP1 WWP2

3.18e-051127221191027
Pubmed

Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.

WWP1 WWP2

3.18e-051127225963657
Pubmed

USP11 augments TGFβ signalling by deubiquitylating ALK5.

WWP1 WWP2

3.18e-051127222773947
Pubmed

Phosphatidylinositol transfer protein/planar cell polarity axis regulates neocortical morphogenesis by supporting interkinetic nuclear migration.

PITPNB PITPNA

5.25e-051427235649377
Pubmed

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

WWP1 WWP2

5.25e-051427231015455
Pubmed

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

HERC4 WWP2

6.92e-051627222496338
Pubmed

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

WWP1 WWP2

6.92e-051627225723849
Pubmed

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

WWP1 WWP2

7.84e-051727228292929
Pubmed

Functional proteomics mapping of a human signaling pathway.

PITPNB QRICH1 LNPEP WWP1 WWP2

8.25e-0559127515231748
Pubmed

Identification of novel human WW domain-containing proteins by cloning of ligand targets.

WWP1 WWP2

8.81e-05182729169421
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

UNK QRICH1 MAPKBP1 WWP1 WWP2

9.43e-0560827516713569
Pubmed

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

WWP1 WWP2

9.84e-051927221572392
Pubmed

PTPN14 is required for the density-dependent control of YAP1.

WWP1 WWP2

1.21e-042127222948661
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

WWP1 WWP2

1.21e-042127237005481
Pubmed

ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.

WWP1 WWP2

1.21e-042127229416926
Pubmed

Rare independent mutations in renal salt handling genes contribute to blood pressure variation.

SLC12A1 SLC12A2

1.33e-042227218391953
Pubmed

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.

WWP1 WWP2

1.33e-042227224850914
Pubmed

A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis.

PITPNB PITPNA

1.72e-042527229587143
Pubmed

WWP2 is an E3 ubiquitin ligase for PTEN.

WWP1 WWP2

2.33e-042927221532586
Pubmed

High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.

OSBPL6 CCDC148

2.49e-043027219401682
Pubmed

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.

PITPNB SLC12A2 HACD3

2.67e-0416227332913203
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

UNK SLC12A1 AFF2 SLC12A2

3.23e-0443027435044719
Pubmed

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.

MAPKBP1 KATNA1

4.01e-043827234059773
Pubmed

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

WWP1 WWP2

4.90e-044227227578003
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

AFF2 HACD3 ABCA13

5.55e-0420827333230847
GeneFamilyC2 and WW domain containing

WWP1 WWP2

7.70e-064212838
GeneFamilyPhosphatidylinositol transfer proteins

PITPNB PITPNA

1.92e-0562121151
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSBPL6 SLC12A1 AFF2 ABCA13

1.58e-06142274191a13bba143ecdfc2bfd797c3ac191481388298
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OSBPL6 SLC12A1 AFF2 ABCA13

1.62e-06143274b405dba9a83a99cc7b53ce71772bc52a0bbb0d4e
ToppCell(09)_Ionocytes|World / shred by cell type and Timepoint

ADGRF5 SLC12A2 HACD3

7.33e-05135273237b9b646513ca6e4b754c0da95d24015b3661f7
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

DNAH10 ABCA13 CCDC148

1.02e-041512738216462e723fec2797387929dde095370947e10a
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

DNAH10 ABCA13 CCDC148

1.13e-0415627310d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.26e-04162273373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCellIonocyte-iono-1|World / Class top

ADGRF5 SLC12A2 HACD3

1.43e-041692734b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OSBPL6 DNAH10 MARCHF4

1.43e-04169273fba841664939c771881ba97f14ef1df6635c04ff
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH10 ABCA13 CCDC148

1.43e-0416927314aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellIonocyte|World / Class top

ADGRF5 SLC12A2 HACD3

1.45e-04170273d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OSBPL6 DNAH10 ABCA13

1.53e-04173273c3762655caa79ac4879876f470d32578a3c93b01
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF2 SLC12A2 ABCA13

1.58e-04175273cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellCiliated_cells-A-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

OSBPL6 DNAH10 CCDC148

1.61e-041762731c364155f46b9a7c995bdc2cc2333c437cd90f5b
ToppCellASK454-Epithelial-Ciliated|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

POC5 ABCA13 CCDC148

1.69e-04179273f21919ef9d3d984e2925ef3d24f89e20fe265dcd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.74e-0418127322363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.77e-04182273a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRF5 SLC12A1 ABCA13

1.77e-041822734c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

DNAH10 ABCA13 CCDC148

1.77e-04182273fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.83e-04184273d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.83e-041842738fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DNAH10 ABCA13 CCDC148

1.86e-0418527318a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellCOVID-19-kidney-Mito-rich_Distal|kidney / Disease (COVID-19 only), tissue and cell type

SLC12A1 CALCR CCDC148

1.92e-041872732ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.92e-041872737ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.92e-0418727377886f99c229610abd28c4c370d2c7d1536c9782
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

OSBPL6 ADGRF5 AFF2

1.92e-04187273fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

DNAH10 ABCA13 CCDC148

1.95e-0418827334b11f72ca73153d02edcd09b38983ad1a504659
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.95e-041882732ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

OSBPL6 ADGRF5 SLC12A2

1.95e-041882731aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.95e-041882733cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.98e-04189273f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

1.98e-04189273e059be2965cca70ff5576df055d0af1775b76e00
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

DNAH10 ABCA13 CCDC148

1.98e-04189273b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

DNAH10 ABCA13 CCDC148

1.98e-0418927327329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellmild-Myeloid-Immature_Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

AFF2 DNAH10 ABCA13

1.98e-0418927394dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

2.01e-04190273b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

2.01e-04190273bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

2.01e-04190273b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 ABCA13 CCDC148

2.01e-041902733fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

2.01e-04190273cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 ABCA13 CCDC148

2.04e-041912739d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

OSBPL6 DNAH10 ABCA13

2.04e-041912737b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OSBPL6 DNAH10 ABCA13

2.04e-041912732a8e6d560907e71e9f6e190ca0667da804e25641
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

OSBPL6 DNAH10 ABCA13

2.04e-041912732d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

2.04e-041912732fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 ABCA13 CCDC148

2.04e-04191273e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSBPL6 DNAH10 ABCA13

2.04e-0419127346c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellCOVID-19-kidney-Mito-rich_Distal|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC12A1 CALCR CCDC148

2.04e-041912730965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCellCOVID-19-kidney-TAL|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC12A1 CALCR CCDC148

2.04e-04191273fe55475ce0666ab5122447a813dc2369e24947b8
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OSBPL6 DNAH10 ABCA13

2.04e-04191273b4e335e798c9617356b8e24412f9270c42dce656
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSBPL6 DNAH10 ABCA13

2.04e-04191273c4b223b33c020a064f576711a3d700eb60a2d737
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

OSBPL6 DNAH10 ABCA13

2.04e-04191273995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSBPL6 DNAH10 ABCA13

2.04e-04191273a37f20172b85566b9039254a89680e37fd503fd5
ToppCellControl-Epithelial-Ciliated|Control / Disease group,lineage and cell class （2021.01.30）

OSBPL6 DNAH10 ABCA13

2.04e-04191273cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

OSBPL6 DNAH10 ABCA13

2.04e-041912736228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSBPL6 DNAH10 ABCA13

2.04e-04191273fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

OSBPL6 DNAH10 ABCA13

2.04e-04191273ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH10 ABCA13 CCDC148

2.04e-041912731c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 CALCR CCDC148

2.08e-04192273562df5e87038c500dd3a003fe5374cb31946b145
ToppCellmild-Myeloid-Immature_Neutrophils_2|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

AFF2 DNAH10 ABCA13

2.08e-041922730445fdc670fa7b847dcd0a061d7736ddcf3519ba
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

OSBPL6 ADGRF5 AFF2

2.08e-0419227355f95454399fd533df75db06584eaa48d6ee3830
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF2 DNAH10 ABCA13

2.11e-04193273ccab6a0c76f574ef7e1d6d5f1e620376daf21bbf
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OSBPL6 DNAH10 ABCA13

2.11e-04193273e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OSBPL6 ADGRF5 DNAH10

2.11e-04193273bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

OSBPL6 DNAH10 ABCA13

2.14e-04194273756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

OSBPL6 ADGRF5 SLC12A2

2.14e-04194273777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AFF2 DNAH10 ABCA13

2.14e-0419427323318a1b55895b5166c6151f488a94a09b4627ff
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

OSBPL6 ADGRF5 DNAH10

2.17e-04195273fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

OSBPL6 ADGRF5 DNAH10

2.17e-04195273eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A2 CALCR CCDC148

2.17e-04195273a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCellCOVID-19-kidney-TAL|kidney / Disease (COVID-19 only), tissue and cell type

SLC12A1 CALCR CCDC148

2.20e-0419627304f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCellPSB|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

OSBPL6 ADGRF5 DNAH10

2.27e-041982734e6b0d1abc55d7a0d89bd7ecf0f13dc5bed66626
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC12A1 ABCA13 LNPEP

2.31e-041992732e7f517c0444b4f29ff11c26ab32e9cc0f7e99ef
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Ciliated|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

OSBPL6 DNAH10 ABCA13

2.34e-04200273a521cf837cadf280505ff9d7e641a205af7d6513
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSBPL6 DNAH10 ABCA13

2.34e-04200273918b576fd9491d23c2bb9d663fa5fb3505cb1c7e
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

OSBPL6 DNAH10 ABCA13

2.34e-04200273ddd39b754bfaa98249d497dfb7e97ec58617a11a
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Npy_(Cortical_subplate_interneuron)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC12A1 DNAH10

6.83e-046427261414e0fa2242f156f0f45f8733b831b7f965dd8
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Npy_(Cortical_subplate_interneuron)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC12A1 DNAH10

6.83e-046427228acc0d394b8cd2fd93ae5e0801f0ff1dd4b16ac
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A

URB1 MAPKBP1 HERC4 ZMYM4 WWP2

3.03e-061952757444_DN
Drugbromide;iodide

SLC12A1 SLC12A2

4.06e-063272CID009907214
DrugBumetanide

SLC12A1 SLC12A2

1.35e-055272DB00887
DrugQuinethazone

SLC12A1 SLC12A2

1.35e-055272DB01325
DrugPotassium Chloride

SLC12A1 SLC12A2

2.03e-056272DB00761
Diseasewaist-hip ratio

ADGRF5 POC5 MAPKBP1 CALCR DNAH10 ZMYM4 WWP2

6.90e-051226267EFO_0004343
Diseasecholesteryl ester measurement, high density lipoprotein cholesterol measurement

POC5 MAPKBP1 DNAH10

2.54e-03312263EFO_0004612, EFO_0010351
Diseasetotal cholesterol measurement, high density lipoprotein cholesterol measurement

POC5 MAPKBP1 DNAH10

2.61e-03315263EFO_0004574, EFO_0004612
Diseasefree cholesterol measurement, high density lipoprotein cholesterol measurement

POC5 MAPKBP1 DNAH10

2.61e-03315263EFO_0004612, EFO_0008591
Diseaselipid measurement, high density lipoprotein cholesterol measurement

POC5 MAPKBP1 DNAH10

2.98e-03330263EFO_0004529, EFO_0004612
Diseasehip circumference

POC5 CALCR DNAH10

3.19e-03338263EFO_0005093
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

AFF2 LNPEP

3.86e-03105262DOID:9352 (implicated_via_orthology)
Diseasephysical activity measurement, body mass index

POC5 CALCR

4.53e-03114262EFO_0004340, EFO_0008002
Diseasesmoking behavior, body mass index

POC5 CALCR

5.25e-03123262EFO_0004318, EFO_0004340
Diseasewaist circumference

POC5 DNAH10 WWP2

6.19e-03429263EFO_0004342
DiseaseMammary Neoplasms, Experimental

SLC12A2 LNPEP

8.20e-03155262C0024668
Diseasevisceral adipose tissue measurement

POC5 DNAH10 WWP1

8.47e-03481263EFO_0004765
Diseaseosteoarthritis, knee

PITPNB WWP2

8.51e-03158262EFO_0004616
Diseasemyeloid white cell count

ADGRF5 QRICH1 DNAH10 LNPEP

8.65e-03937264EFO_0007988
Diseaseepilepsy (implicated_via_orthology)

SLC12A1 SLC12A2

9.04e-03163262DOID:1826 (implicated_via_orthology)
Diseasehigh density lipoprotein particle size measurement

POC5 DNAH10

9.79e-03170262EFO_0008592
Diseasemortality

PITPNB CCDC148

1.01e-02173262EFO_0004352

Protein segments in the cluster

PeptideGeneStartEntry
KEQTLIKQHKQVWWQ

CCDC148

61

Q8NFR7
TVKRQWAQFKIQWNQ

CALCR

401

P30988
NKWQLDKWLNKVTSQ

AFF2

526

P51816
LWKNLKKDNWNVSNV

ABCA13

2746

Q86UQ4
VWKNWAQTKNAELEK

QRICH1

481

Q2TAL8
VTVKFKWWGLQNKVE

PITPNA

196

Q00169
KVWRSVVQKQWKDVV

POC5

286

Q8NA72
RQVNITVQKKVSQWW

HACD3

76

Q9P035
TKQIWTVNEALIQKW

HERC4

396

Q5GLZ8
AWDFVKENWNKLVQK

LNPEP

941

Q9UIQ6
KNFVFWQDIRWKNKF

OSBPL6

686

Q9BZF3
KWWGLQSKVENFIQK

PITPNB

201

P48739
IFKRWQAVNQQWKVL

MARCHF4

301

Q9P2E8
NVWAWKKNIVVASNK

MAPKBP1

161

O60336
QSQKLWQINNQEKSW

FOXR2

176

Q6PJQ5
KWQQVWQEINVEAKH

KATNA1

51

O75449
WKKWVNQIPNKVEQY

DNAH10

2261

Q8IVF4
KIWFQNRRTKWKKQN

NKX1-1

341

Q15270
QFKKKQEKGTIDVWW

SLC12A1

901

Q13621
AKVQVWFQKRWAKII

SEBOX

61

Q9HB31
VVWVWQSLKKQETKQ

URB1

511

O60287
NVNWSKVEWKQEGKI

ADGRF5

396

Q8IZF2
KNSKQIQWFWQVVKE

WWP2

771

O00308
QKKQGKNTIDVWWLF

SLC12A2

1016

P55011
KQIIWFWQFVKETDN

WWP1

826

Q9H0M0
IKQWEESWKQAKQAC

UNK

661

Q9C0B0
VNAWKNWVQWKNAKE

ZMYM4

1211

Q5VZL5