Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	ADGB CAPN14 CAPN3	4.35e-05	17	82	3	GO:0004198
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH6 DNAH8	2.66e-05	14	80	3	IPR011704
Domain	AAA_5	MDN1 DNAH6 DNAH8	2.66e-05	14	80	3	PF07728
Domain	CysPc	ADGB CAPN14 CAPN3	3.32e-05	15	80	3	SM00230
Domain	Peptidase_C2_calpain_cat	ADGB CAPN14 CAPN3	3.32e-05	15	80	3	IPR001300
Domain	Peptidase_C2	ADGB CAPN14 CAPN3	3.32e-05	15	80	3	PF00648
Domain	CALPAIN_CAT	ADGB CAPN14 CAPN3	3.32e-05	15	80	3	PS50203
Domain	-	RBM27 PRPF3	1.80e-04	5	80	2	1.20.1390.10
Domain	PWI	RBM27 PRPF3	1.80e-04	5	80	2	PF01480
Domain	PWI_dom	RBM27 PRPF3	1.80e-04	5	80	2	IPR002483
Domain	Pept_cys_AS	CAPN14 CAPN3 DNAH8	2.29e-04	28	80	3	IPR000169
Domain	Kinase_OSR1/WNK_CCT	WNK3 WNK2	2.69e-04	6	80	2	IPR024678
Domain	OSR1_C	WNK3 WNK2	2.69e-04	6	80	2	PF12202
Domain	-	TRMT44 RBM27 DUS3L	6.67e-04	40	80	3	4.10.1000.10
Domain	Calpain_III	CAPN14 CAPN3	1.16e-03	12	80	2	IPR022683
Domain	calpain_III	CAPN14 CAPN3	1.16e-03	12	80	2	SM00720
Domain	C2_III	CAPN14 CAPN3	1.16e-03	12	80	2	IPR033883
Domain	Calpain_domain_III	CAPN14 CAPN3	1.37e-03	13	80	2	IPR022682
Domain	Calpain_III	CAPN14 CAPN3	1.37e-03	13	80	2	PF01067
Domain	Dynein_heavy_chain_D4_dom	DNAH6 DNAH8	1.59e-03	14	80	2	IPR024317
Domain	Calpain_cysteine_protease	CAPN14 CAPN3	1.59e-03	14	80	2	IPR022684
Domain	Dynein_HC_stalk	DNAH6 DNAH8	1.59e-03	14	80	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH6 DNAH8	1.59e-03	14	80	2	IPR013602
Domain	DHC_N2	DNAH6 DNAH8	1.59e-03	14	80	2	PF08393
Domain	MT	DNAH6 DNAH8	1.59e-03	14	80	2	PF12777
Domain	AAA_8	DNAH6 DNAH8	1.59e-03	14	80	2	PF12780
Domain	DHC_fam	DNAH6 DNAH8	1.83e-03	15	80	2	IPR026983
Domain	Dynein_heavy_dom	DNAH6 DNAH8	1.83e-03	15	80	2	IPR004273
Domain	Dynein_heavy	DNAH6 DNAH8	1.83e-03	15	80	2	PF03028
Domain	Znf_CCCH	TRMT44 RBM27 DUS3L	1.97e-03	58	80	3	IPR000571
Domain	ZF_C3H1	TRMT44 RBM27 DUS3L	1.97e-03	58	80	3	PS50103
Domain	DH_1	TRIO KALRN SOS1	2.50e-03	63	80	3	PS00741
Domain	LH2	LOXHD1 ALOX15	2.65e-03	18	80	2	SM00308
Domain	RhoGEF	TRIO KALRN SOS1	3.10e-03	68	80	3	SM00325
Domain	RhoGEF	TRIO KALRN SOS1	3.37e-03	70	80	3	PF00621
Domain	DH_2	TRIO KALRN SOS1	3.37e-03	70	80	3	PS50010
Domain	AAA+_ATPase	MDN1 IGHMBP2 DNAH6 DNAH8	3.41e-03	144	80	4	IPR003593
Domain	AAA	MDN1 IGHMBP2 DNAH6 DNAH8	3.41e-03	144	80	4	SM00382
Domain	DH-domain	TRIO KALRN SOS1	3.51e-03	71	80	3	IPR000219
Domain	-	TRIO KALRN SOS1	3.51e-03	71	80	3	1.20.900.10
Domain	PLAT	LOXHD1 ALOX15	3.61e-03	21	80	2	PS50095
Domain	-	LOXHD1 ALOX15	3.61e-03	21	80	2	2.60.60.20
Domain	CRAL_TRIO	TRIO KALRN	3.61e-03	21	80	2	PF00650
Domain	PLAT	LOXHD1 ALOX15	3.61e-03	21	80	2	PF01477
Domain	PLAT/LH2_dom	LOXHD1 ALOX15	3.61e-03	21	80	2	IPR001024
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZNF276 MDN1 ARID3A KMT2B PSME4 EP400 SUGP2 TRIO KALRN ZFYVE26 TSC2 KDM6B TTC3 CDC42BPB WNK2	4.98e-08	1105	83	15	35748872
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SPCS3 PPP2R5E MDN1 KMT2B EP400 RBM27 MARS1 NFIB IGHMBP2 SLC25A13 LTN1 ATP5MF XPC CKAP2 NDUFB3 VIRMA CDC42BPB	7.51e-08	1497	83	17	31527615
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	SINHCAF PPP2R5E ARID3A EP400 RBM27 PRPF3 TSC2 XPC SYF2	4.59e-07	396	83	9	26687479
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CEP350 POLR3B PPP2R5E TRIO KALRN ATP5MF TSC2 XPC CKAP2 KDM6B TTC3 CDC42BPB RASAL2 SOS1	2.01e-06	1285	83	14	35914814
Pubmed	A role for Saccharomyces cerevisiae Centrin (Cdc31) in mitochondrial function and biogenesis.	MDN1 NXF5 XPC	2.84e-06	12	83	3	30251372
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	CEP350 SPCS3 SINHCAF MDN1 NFIB NXF5 ATP5MF XPC VIRMA RASAL2	2.94e-06	638	83	10	31182584
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	MDN1 KMT2B SUGP2 ZFYVE26 KDM6B	5.24e-06	104	83	5	9205841
Pubmed	Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.	TSC2 ODC1	5.63e-06	2	83	2	32588887
Pubmed	KMT2B promotes SHPRH expression to regulate 131I sensitivity in thyroid carcinoma cells by affecting FYN protein stability.	KMT2B SHPRH	5.63e-06	2	83	2	34606908
Pubmed	Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3.	LTN1 TTC3	5.63e-06	2	83	2	36917672
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	5.63e-06	2	83	2	26858404
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ACSL6 PPP2R5E SUGP2 TRIO KALRN MARS1 TMPO ATP5MF NDUFB3 DNAH6 VIRMA CDC42BPB WNK2 RASAL2	6.93e-06	1431	83	14	37142655
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CAPN14 POLR3B PPP2R5E KMT2B DPP9 CAPN3 CDC42BPB WNK3 GALNT13 WNK2	9.56e-06	730	83	10	34857952
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SINHCAF ZNF276 MDN1 KMT2B EP400 RBM27 PRPF3 NFIB NUP88 TMPO XPC CKAP2 SYF2	1.16e-05	1294	83	13	30804502
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	PSME4 EP400 MARS1 SLC25A13 TMPO ATP5MF	1.19e-05	211	83	6	17314511
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	POLR3B MDN1 SUGP2 RBM27 PRPF3 IGHMBP2 SLC25A13 TMPO CKAP2 VIRMA	1.34e-05	759	83	10	35915203
Pubmed	Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.	ODC1 KDM6B	1.69e-05	3	83	2	34216539
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	1.69e-05	3	83	2	31801062
Pubmed	WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway.	WNK3 WNK2	1.69e-05	3	83	2	18768590
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM4D KMT2B KDM6B	1.69e-05	21	83	3	27626377
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TCAF1 MDN1 TRIO KALRN TSC2 TTC3 VIRMA CDC42BPB WNK3 WNK2 RASAL2	1.82e-05	963	83	11	28671696
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK3 WNK2	3.37e-05	4	83	2	34384519
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK3 WNK2	3.37e-05	4	83	2	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK3 WNK2	3.37e-05	4	83	2	11498583
Pubmed	Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells.	KDM4D NFIB	3.37e-05	4	83	2	32080306
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	TCAF1 MDN1 EP400 RBM27 PRPF3 SHPRH XPC	4.50e-05	394	83	7	27248496
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DPP9 SUGP2 TRIO PRPF3 MARS1 NFIB TMPRSS6 SHPRH DHRSX CKAP2 TTC3 CDC42BPB WNK2	4.99e-05	1489	83	13	28611215
Pubmed	Assembly of high order G alpha q-effector complexes with RGS proteins.	TRIO KALRN	5.60e-05	5	83	2	18936096
Pubmed	Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.	PPP2R5E TRMT44	8.39e-05	6	83	2	21659360
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	TCAF1 POLR3B EP400 SUGP2 PRPF3 TSC2	8.47e-05	300	83	6	28561026
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	POLR3B MDN1 PSME4 EP400 SUGP2 PRPF3 MARS1 SLC25A13 LTN1 XPC DUS3L RASAL2	8.64e-05	1353	83	12	29467282
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	CEP350 TCAF1 ZNF276 KMT2B SUGP2 KALRN TMPO WNK2	1.04e-04	608	83	8	16713569
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK3 WNK2	1.17e-04	7	83	2	20525693
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SPCS3 PPP2R5E RBM27 MARS1 SQLE LPCAT4 TMPO ATP5MF XPC NDUFB3 VIRMA	1.34e-04	1203	83	11	29180619
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	SINHCAF KMT2B PRPF3 NUP88	1.44e-04	110	83	4	26841866
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK3 WNK2	1.56e-04	8	83	2	23838290
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	WNK3 WNK2	1.56e-04	8	83	2	23387299
Pubmed	Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues.	ALOX15 IL7R	1.56e-04	8	83	2	18774388
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	PSME4 SUGP2 TRIO LTN1 SHPRH	1.58e-04	212	83	5	33853758
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	LOXHD1 MDN1 MARS1 IGHMBP2 SLC25A13 SHPRH TMPO	1.90e-04	497	83	7	36774506
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	MDN1 KMT2B SUGP2 RBM27 PRPF3 MARS1 NFIB XPC SYF2	1.90e-04	847	83	9	35850772
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM4D KMT2B KDM6B	2.23e-04	49	83	3	34368113
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	SPCS3 POLR3B SUGP2 SLC25A13 LTN1 NUP88 DNAH8 VIRMA	2.81e-04	704	83	8	29955894
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	KMT2B EP400 RBM27 PRPF3	3.06e-04	134	83	4	25452129
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM4D KMT2B KDM6B	3.49e-04	57	83	3	18022353
Pubmed	An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation.	PPP2R5E CDC42BPB	3.66e-04	12	83	2	11867214
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	CAPN3 SHPRH TSC2 CKAP2 RASAL2	3.71e-04	255	83	5	15324660
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	POLR3B PPP2R5E SLC25A13 LTN1 NUP88 TMPO CKAP2	3.90e-04	560	83	7	35241646
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	SPCS3 TCAF1 PPP2R5E MARS1 NUP88 TMPO ATP5MF TSC2 WNK3	4.14e-04	942	83	9	31073040
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ADGB SPCS3 EP400 PRPF3 SLC25A13 NUP88 SHPRH TMCO3	4.44e-04	754	83	8	35906200
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	SUGP2 RBM27 PRPF3 XPC	4.46e-04	148	83	4	32538781
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	MDN1 EP400 XPC CKAP2	4.69e-04	150	83	4	28242625
Pubmed	Hereditary Spastic Paraplegia Overview	MARS1 CPT1C ZFYVE26	4.69e-04	63	83	3	20301682
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH6 DNAH8	5.03e-04	14	83	2	9373155
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MDN1 KMT2B EP400 SUGP2 TMPO XPC VIRMA SOS1	5.27e-04	774	83	8	15302935
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KMT2B EP400 KDM6B CDH3	5.57e-04	157	83	4	30186101
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	KDM4D SINHCAF EP400 TSC2 DUS3L	5.77e-04	281	83	5	24163370
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SPCS3 SINHCAF MDN1 SUGP2 RBM27 MARS1 SLC25A13 SQLE TMPO	5.87e-04	989	83	9	36424410
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	EP400 SUGP2 RBM27 PRPF3 TMPO	5.96e-04	283	83	5	30585729
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPCS3 MDN1 MTRES1 SLC25A13 LPCAT4 TMPO XPC TTC3 DNAH6 CCDC191 DNAH8	6.25e-04	1442	83	11	35575683
Pubmed	Polymorphisms in mitochondrial genes and prostate cancer risk.	ACSL6 MARS1 ATP5MF	7.52e-04	74	83	3	19064571
Pubmed	NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.	NFIB CDH3	8.40e-04	18	83	2	23389444
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	TCAF1 SUGP2 NFIB TTC3 WNK3 WNK2	8.47e-04	462	83	6	31138677
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	PPP2R5E MARS1 LTN1 SOS1	9.86e-04	183	83	4	23956138
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	CEP350 RBM27 NUP88 RASAL2	1.01e-03	184	83	4	32908313
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	ARID3A EP400 NFIB	1.05e-03	83	83	3	28794006
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP350 MDN1 TRIO TSC2 CKAP2 VIRMA WNK3 RASAL2	1.05e-03	861	83	8	36931259
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SPCS3 EP400 SUGP2 KALRN RBM27 PRPF3 SLC25A13 TMPO XPC	1.11e-03	1082	83	9	38697112
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TCAF1 SINHCAF PPP2R5E PSME4 MARS1 LTN1 CKAP2 DUS3L TTC3	1.12e-03	1084	83	9	11544199
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SINHCAF PPP2R5E TRMT44 MARS1 SLC25A13 SQLE TSC2 NHLRC2 VIRMA SOS1	1.23e-03	1327	83	10	32694731
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	PPP2R5E TRIO KALRN CAPN3 TTC3 CDC42BPB	1.23e-03	497	83	6	23414517
Pubmed	Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.	DNAH6 CDH3	1.26e-03	22	83	2	33304758
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	KMT2B EP400 SUGP2 RBM27 PRPF3	1.33e-03	339	83	5	30415952
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PPP2R5E EP400 SUGP2 PRPF3 SLC25A13 LTN1 LPCAT4 XPC SOS1	1.37e-03	1116	83	9	31753913
Pubmed	Charcot-Marie-Tooth Neuropathy Type 2 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	MARS1 IGHMBP2	1.38e-03	23	83	2	20301462
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	TRIO LTN1 TMPO CDC42BPB	1.42e-03	202	83	4	33005030
Pubmed	Interaction network of human early embryonic transcription factors.	ARID3A KMT2B EP400 NFIB NUP88	1.55e-03	351	83	5	38297188
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CEP350 SPCS3 TCAF1 EP400 SUGP2 RBM27 TMPO XPC VIRMA CDC42BPB	1.56e-03	1371	83	10	36244648
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	SUGP2 TRIO KALRN CPT1C IGHMBP2 NUP88 ATP5MF CDC42BPB WNK2	1.58e-03	1139	83	9	36417873
Pubmed	Whole-genome sequencing reveals host factors underlying critical COVID-19.	ACSL6 DPP9	1.63e-03	25	83	2	35255492
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPA1 MCOLN3	1.63e-03	25	83	2	16382100
Pubmed	High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.	PRPF3 SOS1	1.63e-03	25	83	2	26627737
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	CEP350 SUGP2 PRPF3 CKAP2	1.64e-03	210	83	4	16565220
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EP400 SUGP2 RBM27 PRPF3 MARS1 NUP88 TMPO CKAP2	1.75e-03	934	83	8	33916271
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	SUGP2 RBM27 PRPF3 MARS1 TMPO SYF2 VIRMA	1.84e-03	731	83	7	29298432
Pubmed	A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.	ACSL6 MARS1 CAPN3 DNAH8	1.87e-03	218	83	4	19460752
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	DNAH8 GALNT13	1.90e-03	27	83	2	18649358
Pubmed	An introduction to TRP channels.	TRPA1 MCOLN3	1.90e-03	27	83	2	16460286
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	SQLE NHLRC2 VIRMA	1.95e-03	103	83	3	29539633
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	MDN1 LTN1 TSC2	2.01e-03	104	83	3	31240132
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2B EP400 SUGP2 RBM27 SLC25A13 TMPO	2.04e-03	549	83	6	38280479
Pubmed	A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.	SPCS3 NXF5	2.04e-03	28	83	2	23677977
Pubmed	Human transcription factor protein interaction networks.	SINHCAF ARID3A KMT2B EP400 SUGP2 RBM27 MARS1 NFIB SLC25A13 NUP88	2.12e-03	1429	83	10	35140242
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	TRIO LTN1 TMPO CDC42BPB	2.28e-03	230	83	4	35449600
Cytoband	6q24.3	ADGB SHPRH	1.76e-04	11	83	2	6q24.3
GeneFamily	C2 domain containing\|Calpains	ADGB CAPN14 CAPN3	1.18e-05	15	55	3	975
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO KALRN SOS1	1.06e-03	66	55	3	722
GeneFamily	Dyneins, axonemal	DNAH6 DNAH8	1.20e-03	17	55	2	536
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM4D KDM6B	2.40e-03	24	55	2	485
GeneFamily	Transient receptor potential cation channels	TRPA1 MCOLN3	3.26e-03	28	55	2	249
Drug	stearoylcarnitine	CPT1C ACAD10 ODC1	5.31e-06	10	82	3	CID000005282
Drug	Sulfaphenazole [526-08-9]; Down 200; 12.8uM; HL60; HT_HG-U133A	PSME4 SUGP2 SQLE CAPN3 TMPO TSC2 KDM6B	6.71e-06	195	82	7	1836_DN
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK3 WNK2	1.03e-04	6	78	2	DOID:4479 (implicated_via_orthology)
Disease	Macrocephaly	NFIB ODC1	3.74e-04	11	78	2	C0221355
Disease	platelet crit	KALRN RBM27 PRPF3 TMPRSS6 NHLRC2 SYF2 KDM6B CDH3 RASAL2	9.07e-04	952	78	9	EFO_0007985
Disease	Charcot-Marie-Tooth disease type 2	MARS1 IGHMBP2	9.14e-04	17	78	2	cv:C0270914
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B TRIO	9.14e-04	17	78	2	DOID:0060307 (is_implicated_in)
Disease	Intellectual Disability	POLR3B TRIO NFIB NXF5 ODC1 KDM6B	1.20e-03	447	78	6	C3714756
Disease	Micronuclei, Chromosome-Defective	PPP2R5E XPC	2.15e-03	26	78	2	C1449861
Disease	Micronuclei, Genotoxicant-Induced	PPP2R5E XPC	2.15e-03	26	78	2	C1449862
Disease	corpus callosum volume measurement	PPP2R5E WNK2 SOS1	2.39e-03	100	78	3	EFO_0010299
Disease	Bell's palsy	RBM27 NFIB DNAH8	2.53e-03	102	78	3	EFO_0007167
Disease	HIV Coinfection	PSME4 NUP88 ODC1	2.60e-03	103	78	3	C4505456
Disease	HIV Infections	PSME4 NUP88 ODC1	2.60e-03	103	78	3	C0019693

Protein segments in the cluster

Peptide	Gene	Start	Entry
LWKKLEDLELKRGLR	PPP2R5E	446	Q16537
ELELKRWCPGLKILS	EP400	1156	Q96L91
FKWLKPVRGSLLLLA	ERVK13-1	451	Q9NX77
WEALSLIKDLGLRPK	CPQ	311	Q9Y646
KVWELLKEILPEFKL	ADGB	286	Q8N7X0
KARWLIPLLEGKARS	ACAD10	776	Q6JQN1
LWALEPEKALVRLVK	ACOT6	81	Q3I5F7
KPLKSILQKEGTRLW	ARL13A	241	Q5H913
RGALLKPWLFTEIKE	DUS3L	521	Q96G46
WELLSPKEKILLLRK	CAPN14	296	A8MX76
LSEWKAGKGRVLKRP	CKAP2	371	Q8WWK9
TIQKKLAAKGLRDPW	NDUFB3	31	O43676
VDALKSWLAKLLEPI	RBM27	6	Q9P2N5
PEIKQKWASRLLAKL	NFIB	66	O00712
LVTPWLKGDILGEKL	LTN1	731	O94822
GLLIKEKWEAFGLRL	MDN1	786	Q9NU22
SLLKREWLLLAKGEP	M1AP	356	Q8TC57
ALEPQLWELGKVLRK	LPCAT4	321	Q643R3
RGRKPWKLAIQILKI	MCOLN3	56	Q8TDD5
DAKRWKPQLQELLKL	KDM6B	1336	O15054
KWFKPGIIEKFRIEL	LOXHD1	466	Q8IVV2
LSLKWKDGLRVLILP	NXF5	366	Q9H1B4
KLPKGLKDWQAFLDL	DNAH8	1321	Q96JB1
GRVALVKVLDKWPLR	NRG2	156	O14511
RGSKWDLIKPLLKTL	KALRN	101	O60229
LRLWIIEAKDLAPKK	RASAL2	171	Q9UJF2
AGLAKIIPPKEWKAR	KDM4D	46	Q6B0I6
GKRLWPARGKETELK	ALOX15	36	P16050
LVILACVLWKKRIKP	IL7R	256	P16871
LAKKGRTIVKTLLPW	KMT2B	1016	Q9UMN6
KKGRSIPVWIKILLF	TMPO	406	P42167
RLKKLEQLLLDGPWR	CDC42BPB	6	Q9Y5S2
IWALLLDSGKLPKKN	NHLRC2	366	Q8NBF2
GWLEPLLARIKEDRK	GALNT13	216	Q8IUC8
LGLMEKIKELLPDWG	CPT1C	81	Q8TCG5
KKLLEVKLGELPSWI	ATP5MF	16	P56134
SLKPLGSWVKDLILR	DNAH6	3956	Q9C0G6
IPKKVRKEALLLLSW	DPP9	91	Q86TI2
RVLLRKKGLEPWKRL	CCDC191	746	Q8NCU4
KDIKLWRKLLKGIPD	SQLE	426	Q14534
ETIKLGIKSRPKGLW	HYAL4	201	Q2M3T9
WRDGQKLVKKILGPA	CEP350	426	Q5VT06
RLAKKLLGWLLFKTP	DHRSX	256	Q8N5I4
SELGKLWRKLFKGIP	C20orf173	56	Q96LM9
FKGEKVKLVRLRNPW	CAPN3	346	P20807
WLLLNKPLDREEIAK	CDH3	166	P22223
GDILKKHLRWLKALP	ODC1	46	P11926
ILLLKKDHAKGWLRL	IL17RC	556	Q8NAC3
LKPWIEKTVKRVLGF	PRPF3	11	O43395
IGIKGLMVLELPKRW	NUP88	126	Q99567
TEALLWLKRGLKFLK	PLEKHA8P1	286	O95397
KPTWLGEELLAKLAK	TRMT44	266	Q8IYL2
LLIWIKKNLLKERPE	URM1	41	Q9BTM9
RLKLPANWEAKKARL	SYF2	61	O95926
GLEFSPEKLRKVWKI	TMCO3	336	Q6UWJ1
LINEKLIRTKGLWGP	TCAF1	741	Q9Y4C2
LQRKGGIKKRAWPLD	PIK3R6	366	Q5UE93
WDKIVLRGDNPKLLL	SPCS3	106	P61009
LEDLGWLQKKRRIKL	SHPRH	186	Q149N8
VKLLAGVLRKPDAWI	MTRES1	6	Q9P0P8
APKWRGLLVPALKKV	SOS1	16	Q07889
IGKWLPAGTLKIIDR	ACSL6	541	Q9UKU0
KKLWREITKGLNLPT	ARID3A	291	Q99856
FRKILREEGPKALWK	SLC25A13	566	Q9UJS0
CVLLVKRWKKLPAGS	SINHCAF	56	Q9NP50
LEKKLPLWFLRKVDQ	TRPA1	986	O75762
WIPLLKARKCILAGD	IGHMBP2	386	P38935
KKKLLPWQRRGLLRA	SUGP2	671	Q8IX01
KPGWKKKLRCEREEL	ZNF276	416	Q8N554
LKEVEPKLAAWIQKL	TTC3	896	P53804
KWRLLPAFLKVKGLV	POLR3B	26	Q9NW08
EKVEKLWELLCPLLR	PSME4	1396	Q14997
LLEKGKEPWKILRDE	ZNF790	56	Q6PG37
GKEPWLGKREVKRDL	ZNF140	61	P52738
LRLWVEDPKKLKGKP	WNK2	476	Q9Y3S1
EKRALGNWKLLAKGL	XPC	841	Q01831
AKLQELGKWLEPLKN	VIRMA	886	Q69YN4
LGKWLEPLKNLRFEI	VIRMA	891	Q69YN4
LVLEKWLAREKKLLP	ZFYVE26	81	Q68DK2
FLDLPKLEKRLEEWL	MARS1	451	P56192
RGSKWDSIKPLLKIL	TRIO	131	O75962
SDWKVLKLVLGRLPE	TSC2	701	P49815
GPKDLMLKLRLEWTL	TMPRSS6	251	Q8IU80
LALRLWVEDPKKLKG	WNK3	426	Q9BYP7