Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase binding	TAOK2 TRIB3 MAP3K1	9.57e-05	19	95	3	GO:0031434
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	PHF8 KDM6B	2.22e-04	5	95	2	GO:0071558
GeneOntologyMolecularFunction	histone H3K9me/H3K9me2 demethylase activity	KDM3B PHF8	2.22e-04	5	95	2	GO:0140683
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	TAOK2 MAP3K13 MAP3K1	2.81e-04	27	95	3	GO:0004709
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM3B PHF8 KDM6B	3.14e-04	28	95	3	GO:0141052
GeneOntologyMolecularFunction	enzyme regulator activity	TAOK2 COL6A3 SH3PXD2B ERCC6 PDE6H TRIB3 ARHGAP23 SRGAP1 RPS6KA1 RAPGEF1 AKAP11 MAP3K13 DENND1A TNS3 RCAN2 OPHN1 SH3BP4	3.46e-04	1418	95	17	GO:0030234
GeneOntologyMolecularFunction	histone demethylase activity	KDM3B PHF8 KDM6B	4.26e-04	31	95	3	GO:0032452
GeneOntologyMolecularFunction	actin binding	KLHL3 GAS2L3 GAS2L2 MAPT CAMK2B RUSC1 SPIRE1 MYO15A OPHN1	4.62e-04	479	95	9	GO:0003779
GeneOntologyMolecularFunction	protein demethylase activity	KDM3B PHF8 KDM6B	4.68e-04	32	95	3	GO:0140457
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TAOK2 CDK8 TRIB3 PIK3C2B CAMK2B RPS6KA1 MAP3K13 HUNK PRAG1 MAP3K1 TXK	5.44e-04	709	95	11	GO:0016773
GeneOntologyMolecularFunction	protein kinase activity	TAOK2 CDK8 TRIB3 CAMK2B RPS6KA1 MAP3K13 HUNK PRAG1 MAP3K1 TXK	5.68e-04	600	95	10	GO:0004672
GeneOntologyMolecularFunction	protein phosphatase 1 binding	AKAP11 CDC5L PPP1CC	6.11e-04	35	95	3	GO:0008157
GeneOntologyMolecularFunction	kinase activity	TAOK2 CDK8 TRIB3 PIK3C2B CAMK2B RPS6KA1 MAP3K13 HUNK PRAG1 MAP3K1 TXK	1.00e-03	764	95	11	GO:0016301
GeneOntologyMolecularFunction	demethylase activity	KDM3B PHF8 KDM6B	1.20e-03	44	95	3	GO:0032451
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	MAP3K13 MAP3K1	1.43e-03	12	95	2	GO:0004706
GeneOntologyMolecularFunction	protein serine kinase activity	TAOK2 CDK8 CAMK2B RPS6KA1 MAP3K13 HUNK MAP3K1	1.74e-03	363	95	7	GO:0106310
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM3B PHF8	1.96e-03	14	95	2	GO:0032454
GeneOntologyMolecularFunction	cytoskeletal protein binding	TAOK2 KLHL3 GAS2L3 GAS2L2 MAPT CAMK2B APC2 NAV3 RUSC1 SPIRE1 MYO15A MAP3K1 OPHN1	2.07e-03	1099	95	13	GO:0008092
GeneOntologyMolecularFunction	cGMP binding	PDE6H CNGB1	2.57e-03	16	95	2	GO:0030553
GeneOntologyMolecularFunction	protein kinase binding	TAOK2 SASH1 TRIB3 MAPT RBBP6 CAMK2B AKAP11 MAP3K13 CDC5L MAP3K1 PPP1CC	2.87e-03	873	95	11	GO:0019901
GeneOntologyBiologicalProcess	central tolerance induction	AIRE FOXJ1	2.10e-05	2	95	2	GO:0002508
GeneOntologyBiologicalProcess	DNA damage response	TAOK2 USP10 TICRR ERCC6 SNW1 MAPT RBBP6 TIPIN NYNRIN RECQL5 SPIRE1 MAEL CHD2 CDC5L PIAS1	3.11e-05	959	95	15	GO:0006974
GeneOntologyCellularComponent	nuclear speck	SNW1 MAPT RBBP6 ACIN1 CDC5L PIAS1 SAP130 GATAD2B PPP1CC	1.52e-04	431	95	9	GO:0016607
GeneOntologyCellularComponent	actin cytoskeleton	TAOK2 SH3PXD2B GAS2L3 GAS2L2 APC2 MYO15A MAP3K1 TNS3 OPHN1 CYBA	2.89e-04	576	95	10	GO:0015629
Domain	SH3	SH3PXD2B SASH1 SRGAP1 CASKIN1 SH3D19 RUSC1 MYO15A SH3BP4 TXK	1.42e-06	216	94	9	SM00326
Domain	SH3	SH3PXD2B SASH1 SRGAP1 CASKIN1 SH3D19 RUSC1 MYO15A SH3BP4 TXK	1.42e-06	216	94	9	PS50002
Domain	SH3_domain	SH3PXD2B SASH1 SRGAP1 CASKIN1 SH3D19 RUSC1 MYO15A SH3BP4 TXK	1.66e-06	220	94	9	IPR001452
Domain	SH3_2	SH3PXD2B SASH1 CASKIN1 SH3D19 MYO15A SH3BP4	4.70e-06	86	94	6	IPR011511
Domain	SH3_2	SH3PXD2B SASH1 CASKIN1 SH3D19 MYO15A SH3BP4	4.70e-06	86	94	6	PF07653
Domain	S_TKc	TAOK2 CDK8 TRIB3 CAMK2B RPS6KA1 MAP3K13 HUNK PRAG1 MAP3K1	8.19e-05	359	94	9	SM00220
Domain	Kinase-like_dom	TAOK2 CDK8 TRIB3 PIK3C2B CAMK2B RPS6KA1 MAP3K13 HUNK PRAG1 MAP3K1 TXK	8.70e-05	542	94	11	IPR011009
Domain	Pkinase	TAOK2 CDK8 TRIB3 CAMK2B RPS6KA1 MAP3K13 HUNK PRAG1 MAP3K1	1.29e-04	381	94	9	PF00069
Domain	Prot_kinase_dom	TAOK2 CDK8 TRIB3 CAMK2B RPS6KA1 MAP3K13 HUNK PRAG1 MAP3K1 TXK	1.75e-04	489	94	10	IPR000719
Domain	SH3_1	SH3PXD2B SRGAP1 SH3D19 RUSC1 SH3BP4 TXK	1.80e-04	164	94	6	PF00018
Domain	PROTEIN_KINASE_DOM	TAOK2 CDK8 TRIB3 CAMK2B RPS6KA1 MAP3K13 HUNK PRAG1 MAP3K1 TXK	1.87e-04	493	94	10	PS50011
Domain	JmjC	KDM3B PHF8 KDM6B	2.31e-04	24	94	3	PF02373
Domain	CH	MICALL1 GAS2L3 GAS2L2 NAV3	3.22e-04	65	94	4	SM00033
Domain	GAR	GAS2L3 GAS2L2	3.71e-04	6	94	2	PS51460
Domain	-	GAS2L3 GAS2L2	3.71e-04	6	94	2	3.30.920.20
Domain	GAS_dom	GAS2L3 GAS2L2	3.71e-04	6	94	2	IPR003108
Domain	GAS2	GAS2L3 GAS2L2	3.71e-04	6	94	2	PF02187
Domain	GAS2	GAS2L3 GAS2L2	3.71e-04	6	94	2	SM00243
Domain	CH	MICALL1 GAS2L3 GAS2L2 NAV3	4.28e-04	70	94	4	PF00307
Domain	-	MICALL1 GAS2L3 GAS2L2 NAV3	4.52e-04	71	94	4	1.10.418.10
Domain	CH	MICALL1 GAS2L3 GAS2L2 NAV3	5.02e-04	73	94	4	PS50021
Domain	JMJC	KDM3B PHF8 KDM6B	5.51e-04	32	94	3	PS51184
Domain	JmjC_dom	KDM3B PHF8 KDM6B	5.51e-04	32	94	3	IPR003347
Domain	CH-domain	MICALL1 GAS2L3 GAS2L2 NAV3	5.57e-04	75	94	4	IPR001715
Domain	JmjC	KDM3B PHF8 KDM6B	6.04e-04	33	94	3	SM00558
Domain	Ser/Thr_kinase_AS	TAOK2 CDK8 CAMK2B RPS6KA1 MAP3K13 HUNK MAP3K1	2.17e-03	357	94	7	IPR008271
Domain	PROTEIN_KINASE_ATP	TAOK2 CDK8 CAMK2B RPS6KA1 MAP3K13 HUNK MAP3K1 TXK	2.20e-03	459	94	8	PS00107
Domain	PROTEIN_KINASE_ST	TAOK2 CDK8 CAMK2B RPS6KA1 MAP3K13 HUNK MAP3K1	2.34e-03	362	94	7	PS00108
Domain	Protein_kinase_ATP_BS	TAOK2 CDK8 CAMK2B RPS6KA1 HUNK MAP3K1 TXK	3.03e-03	379	94	7	IPR017441
Domain	RhoGAP	ARHGAP23 SRGAP1 OPHN1	3.77e-03	62	94	3	SM00324
Domain	RhoGAP	ARHGAP23 SRGAP1 OPHN1	3.94e-03	63	94	3	PF00620
Domain	RHOGAP	ARHGAP23 SRGAP1 OPHN1	4.12e-03	64	94	3	PS50238
Domain	RhoGAP_dom	ARHGAP23 SRGAP1 OPHN1	4.12e-03	64	94	3	IPR000198
Domain	-	ARHGAP23 SRGAP1 OPHN1	4.12e-03	64	94	3	1.10.555.10
Domain	SAM_1	SASH1 CASKIN1 ANKS1A	4.88e-03	68	94	3	PF00536
Domain	-	ACIN1 PIAS1	4.95e-03	21	94	2	1.10.720.30
Domain	SAP	ACIN1 PIAS1	5.42e-03	22	94	2	PF02037
Domain	SAP	ACIN1 PIAS1	5.92e-03	23	94	2	SM00513
Domain	SAP	ACIN1 PIAS1	6.97e-03	25	94	2	PS50800
Domain	SAP_dom	ACIN1 PIAS1	6.97e-03	25	94	2	IPR003034
Pathway	PID_IFNG_PATHWAY	CAMK2B RAPGEF1 PIAS1 MAP3K1	4.71e-05	40	71	4	M161
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 MICALL1 HIVEP3 SH3PXD2B TRIB3 PIK3C2B CASKIN1 AOC2 KIAA0319L KDM3B RAPGEF1 SPIRE1 KDM6B PRAG1 DENND1A HCFC1 TRAPPC9 RAI1 SYMPK SH3BP4	1.66e-11	1105	95	20	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MICALL1 SH3PXD2B SASH1 PIK3C2B MAPT SRGAP1 SH3D19 KDM3B MIEF1 SPIRE1 AKAP11 MAP7 PRAG1 DENND1A TRAPPC9 TNS3 SH3BP4 ANKS1A	1.91e-11	861	95	18	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TAOK2 MICALL1 USP10 SASH1 CASKIN1 KDM3B IPO13 SPIRE1 AKAP11 KDM6B RAI1 ANKS1A	2.36e-08	529	95	12	14621295
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TAOK2 NSFL1C RBBP6 KDM3B ACIN1 PHF8 SAP130 HCFC1 GATAD2B SYMPK	3.48e-08	341	95	10	32971831
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	USP10 SH3PXD2B SNW1 RBBP6 SH3D19 KDM3B ACIN1 CDC5L PHF8 SAP130 HCFC1 SYMPK	3.54e-08	549	95	12	38280479
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SNW1 KDM3B ACIN1 CDC5L PIAS1 HCFC1 GATAD2B SYMPK	1.71e-07	220	95	8	35785414
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 USP10 SH3PXD2B SNW1 PRR36 CAMK2B CASKIN1 SH3D19 APC2 CDC5L GATAD2B RAI1 PPP1CC ANKS1A	3.62e-07	963	95	14	28671696
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	SASH1 PIK3C2B SPIRE1 PRAG1 SH3BP4 ANKS1A	3.86e-07	102	95	6	15778465
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	BCL9L SNW1 RBBP6 ACIN1 CHD2 CDC5L HCFC1 GATAD2B PPP1CC ANKS1A	6.57e-07	469	95	10	27634302
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	USP10 SNW1 RBBP6 KDM3B ACIN1 CHD2 CDC5L PHF8 MYO15A PIAS1 SAP130 HCFC1 GATAD2B SYMPK	6.69e-07	1014	95	14	32416067
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PDE6H ARHGAP23 CAMK2B RPS6KA1 AKAP11 CHD2 MAP3K13 PRAG1 METAP2 GATAD2B MAP3K1 TNS3 PPP1CC	1.19e-06	910	95	13	36736316
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	SNW1 RBBP6 KDM3B ACIN1 CDC5L ZHX2 SAP130 HCFC1 GATAD2B	1.55e-06	399	95	9	35987950
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SNW1 PDE6H RBBP6 RECQL5 ACIN1 ZDBF2 CDC5L SAP130 HCFC1 GATAD2B RAI1 SYMPK PPP1CC	2.01e-06	954	95	13	36373674
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	TICRR SNW1 RBBP6 RECQL5 ACIN1 CHD2 CDC5L PHF8 MAP7 SAP130 HCFC1 GATAD2B RAI1 SYMPK PPP1CC	2.26e-06	1294	95	15	30804502
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	USP10 SNW1 KDM3B CDC5L ZHX2 PIAS1 HCFC1 GATAD2B SYMPK	3.70e-06	444	95	9	34795231
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	SNW1 KDM3B ZDBF2 CDC5L SAP130 HCFC1 GATAD2B PPP1CC	4.37e-06	339	95	8	30415952
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ERCC6 RECQL5 KDM3B CHD2 PHF8 PIAS1 METAP2 HCFC1 GATAD2B RAI1	6.60e-06	608	95	10	36089195
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RPF1 USP10 TICRR ERCC6 SNW1 RBBP6 ACIN1 CDC5L PHF8 SAP130 MAP3K1	7.36e-06	759	95	11	35915203
Pubmed	Functional interaction of AIRE with PIAS1 in transcriptional regulation.	AIRE PIAS1	7.38e-06	2	95	2	18083234
Pubmed	KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2.	MAPT KDM6B	7.38e-06	2	95	2	36028572
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MICALL1 USP10 NSFL1C MAPT RBBP6 KDM3B ACIN1 PHF8 GATAD2B SYMPK ANKS1A	8.84e-06	774	95	11	15302935
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	SNW1 RBBP6 ACIN1 GATAD2B RAI1	9.69e-06	103	95	5	32744500
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	SH3PXD2B PIK3C2B RBBP6 HUNK PPP1CC	9.69e-06	103	95	5	21706016
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	BCL9L KIAA0319L SLITRK5 PIAS1 RAI1 SH3BP4	1.05e-05	180	95	6	35198878
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	MICALL1 SH3PXD2B SRGAP1 SH3D19 MAP7	1.22e-05	108	95	5	19531213
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDK8 HIVEP3 USP10 MAPT CAMK2B SPIRE1 CHD2 ZHX2 ARMC2 DENND1A SAP130 TRAPPC9 RAI1 SH3BP4 ANKS1A	1.22e-05	1489	95	15	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TAOK2 BCL9L USP10 ERCC6 RBBP6 RECQL5 SPIRE1 CHD2 MAP7 ZHX2 DENND1A PIAS1 GATAD2B PPP1CC CYBA	1.30e-05	1497	95	15	31527615
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	MICALL1 USP10 SNW1 NSFL1C MAPT SH3D19 KIAA0319L SLITRK5 MIEF1 CDC5L GATAD2B PPP1CC	1.96e-05	1007	95	12	34597346
Pubmed	Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.	PHF8 KDM6B	2.21e-05	3	95	2	27133168
Pubmed	Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance.	GAS2L2 FOXJ1	2.21e-05	3	95	2	30665704
Pubmed	Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.	TAOK2 MAPT	2.21e-05	3	95	2	23585562
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	TAOK2 SNW1 ACIN1 ZDBF2 CDC5L SAP130 HCFC1 GATAD2B PPP1CC	3.21e-05	583	95	9	29844126
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	NSFL1C KDM3B MIEF1 ZDBF2 CDC5L GPR108 HCFC1 GATAD2B TNS3 ANKS1A	3.28e-05	733	95	10	34672954
Pubmed	Human transcription factor protein interaction networks.	MRPS18A BCL9L SNW1 RBBP6 RECQL5 PHF8 MAP7 ZHX2 PIAS1 SAP130 HCFC1 TRAPPC9 GATAD2B SYMPK	3.33e-05	1429	95	14	35140242
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ERCC6 SNW1 RECQL5 PHF8 PIAS1 HCFC1	3.42e-05	222	95	6	37071664
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	PIK3C2B MAPT RAPGEF1 TNS3 ANKS1A	3.46e-05	134	95	5	24658140
Pubmed	In silico prediction of physical protein interactions and characterization of interactome orphans.	PIK3C2B MAPT RAPGEF1 TNS3 ANKS1A	3.71e-05	136	95	5	25402006
Pubmed	GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.	GAS2L3 GAS2L2	4.41e-05	4	95	2	24706950
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CDK8 ERCC6 ARHGAP23 MAPT RBBP6 E2F2 PHF8 MAP7 GPR108 SAP130 GATAD2B RAI1	5.30e-05	1116	95	12	31753913
Pubmed	Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.	SNW1 ACIN1 CDC5L ZHX2	6.71e-05	79	95	4	14729942
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SNW1 RBBP6 ACIN1 CDC5L HCFC1 SYMPK	6.76e-05	251	95	6	31076518
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	USP10 ERCC6 RBBP6 ACIN1 MAP7 HCFC1 GATAD2B SH3BP4	7.32e-05	503	95	8	16964243
Pubmed	The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.	RPS6KA1 CYBA	7.34e-05	5	95	2	20304964
Pubmed	Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.	AKAP11 PPP1CC	7.34e-05	5	95	2	10209101
Pubmed	Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.	TRIB3 KDM6B	7.34e-05	5	95	2	23515163
Pubmed	Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.	CDK8 E2F2	7.34e-05	5	95	2	12145330
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	MICALL1 MIEF1 ACIN1 CDC5L SH3BP4 ANKS1A	7.38e-05	255	95	6	15324660
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	HIVEP3 KDM3B AIRE ACIN1 E2F2 MAEL CDC5L PHF8 PIAS1 GATAD2B	7.39e-05	808	95	10	20412781
Pubmed	Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.	IRAG1 ZHX2 ARMC2	7.60e-05	30	95	3	20080650
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	SNW1 RBBP6 KDM3B ACIN1 SPIRE1 CDC5L GATAD2B PPP1CC	7.63e-05	506	95	8	30890647
Pubmed	Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).	USP10 RBBP6 HCFC1	8.40e-05	31	95	3	26678539
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CDK8 BCL9L KDM3B SAP130 HCFC1 RAI1	9.69e-05	268	95	6	33640491
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM3B PHF8 KDM6B	1.01e-04	33	95	3	26864203
Pubmed	PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.	PHF8 HCFC1	1.10e-04	6	95	2	20622854
Pubmed	The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.	CDK8 HCFC1	1.10e-04	6	95	2	14983011
Pubmed	A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting.	RTL5 NYNRIN	1.10e-04	6	95	2	16155747
Pubmed	Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells.	AIRE FOXJ1	1.10e-04	6	95	2	35714609
Pubmed	Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.	CDK8 SNW1 SYMPK	1.11e-04	34	95	3	12549820
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	TAOK2 HIVEP3 AKAP11 ZDBF2	1.12e-04	90	95	4	15033168
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	TAOK2 CDK8 PIK3C2B CAMK2B TRAPPC9 PPP1CC	1.14e-04	276	95	6	28319085
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	MICALL1 USP10 ERCC6 SNW1 RBBP6 RAI1	1.26e-04	281	95	6	24163370
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	SNW1 NSFL1C RBBP6 ACIN1 HCFC1 PPP1CC	1.30e-04	283	95	6	30585729
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	USP10 ARHGAP23 PRR36 MAPT CAMK2B CASKIN1 SPIRE1 CDC5L MAP7 METAP2 TRAPPC9 OPHN1 PPP1CC	1.39e-04	1431	95	13	37142655
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	MRPS18A CDK8 USP10 SNW1 NSFL1C RBBP6 ACIN1 CDC5L HCFC1 TNS3 PPP1CC SH3BP4	1.51e-04	1247	95	12	27684187
Pubmed	A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.	AKAP11 PPP1CC	1.54e-04	7	95	2	12147701
Pubmed	Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing.	SNW1 CDC5L	1.54e-04	7	95	2	21639856
Pubmed	Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.	HCFC1 PPP1CC	1.54e-04	7	95	2	10637318
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MICALL1 USP10 SH3PXD2B SNW1 NSFL1C MAPT METAP2 TNS3 PPP1CC	1.67e-04	724	95	9	36232890
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	RBBP6 ACIN1 CDC5L GATAD2B PPP1CC	2.03e-04	195	95	5	19454010
Pubmed	RBBP6 activates the pre-mRNA 3' end processing machinery in humans.	RBBP6 SYMPK	2.05e-04	8	95	2	35177536
Pubmed	The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.	CDK8 TICRR	2.05e-04	8	95	2	30695077
Pubmed	Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.	MAPT PPP1CC	2.05e-04	8	95	2	16262633
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PIK3C2B RBBP6 CAMK2B RECQL5 E2F2 ZDBF2 MAP7 PIAS1	2.13e-04	588	95	8	38580884
Pubmed	Functional proteomics mapping of a human signaling pathway.	ERCC6 SASH1 RBBP6 KDM3B PIAS1 SAP130 GATAD2B PPP1CC	2.21e-04	591	95	8	15231748
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	SAP130 HCFC1 GATAD2B SYMPK PPP1CC	2.44e-04	203	95	5	22083510
Pubmed	Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.	MAPT RPS6KA1	2.62e-04	9	95	2	17512525
Pubmed	A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.	ZHX2 PIAS1	2.62e-04	9	95	2	17533377
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	AKAP11 ZDBF2 MAP7 TNS3 ANKS1A	2.79e-04	209	95	5	36779422
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TAOK2 BCL9L NSFL1C MAPT CAMK2B CASKIN1 NAV3 SLITRK5 ZDBF2 GATAD2B PPP1CC	2.81e-04	1139	95	11	36417873
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	RPF1 SH3PXD2B SNW1 NAV3 KDM3B METAP2	3.03e-04	331	95	6	19490893
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	SNW1 ACIN1 HCFC1 GATAD2B SYMPK PPP1CC	3.08e-04	332	95	6	32786267
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ERCC6 SNW1 NSFL1C ARHGAP23 RECQL5 ACIN1 CHD2 CDC5L PHF8 METAP2 TNS3 PPP1CC	3.18e-04	1353	95	12	29467282
Pubmed	Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach.	CAMK2B PPP1CC	3.28e-04	10	95	2	20124353
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM3B PHF8 KDM6B	3.32e-04	49	95	3	34368113
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	USP10 ARHGAP23 CASKIN1 NAV3 CDC5L TRAPPC9 OPHN1	3.33e-04	475	95	7	31040226
Pubmed	Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.	SH3PXD2B SRGAP1 MYO15A	3.53e-04	50	95	3	19807924
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	TAOK2 USP10 SNW1 GAS2L3 MIEF1 ACIN1 CHD2 DENND1A METAP2 HCFC1 MAP3K1 PPP1CC	3.58e-04	1371	95	12	36244648
Pubmed	Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.	CDK8 SNW1	4.00e-04	11	95	2	15546612
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	TICRR GAS2L3 PIK3C2B RPS6KA1 E2F2	4.08e-04	227	95	5	26410627
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	PHF8 HCFC1 TRAPPC9 GATAD2B	4.43e-04	129	95	4	23022380
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	KDM3B PIAS1 HCFC1 GATAD2B SYMPK PPP1CC	4.52e-04	357	95	6	37059091
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	SNW1 KDM3B ACIN1 SYMPK	4.56e-04	130	95	4	35545047
Pubmed	Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions.	MAPT FOXJ1	4.79e-04	12	95	2	33326788
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SNW1 KDM3B CDC5L HCFC1	5.11e-04	134	95	4	25452129
Pubmed	Protein phosphatase 1γ isoforms linked interactions in the brain.	ZDBF2 PIAS1 PPP1CC	5.19e-04	57	95	3	23080069
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	COL6A3 ERCC6 ARHGAP23 APC2 CDC5L HCFC1 PPP1CC	5.27e-04	513	95	7	25798074
Pubmed	A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.	AIRE PHF8	5.65e-04	13	95	2	20953165
Pubmed	An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures.	KDM3B SAP130	5.65e-04	13	95	2	18986647
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	TAOK2 CAMK2B CASKIN1 PPP1CC ANKS1A	6.43e-04	251	95	5	27507650
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	USP10 SNW1 ZDBF2 MAP7 HCFC1	7.02e-04	256	95	5	33397691
Interaction	YWHAG interactions	TAOK2 MICALL1 TICRR SASH1 ARHGAP23 PIK3C2B MAPT SRGAP1 RPS6KA1 SH3D19 KDM3B MIEF1 ACIN1 SPIRE1 AKAP11 CDC5L MAP7 PRAG1 DENND1A PIAS1 TRAPPC9 MAP3K1 TNS3 SH3BP4 ANKS1A	3.24e-10	1248	94	25	int:YWHAG
Interaction	YWHAB interactions	MICALL1 TICRR SASH1 ARHGAP23 PIK3C2B MAPT CAMK2B SRGAP1 RPS6KA1 SH3D19 MIEF1 SPIRE1 AKAP11 MAP7 DENND1A SAP130 TNS3 PPP1CC SH3BP4 ANKS1A	3.50e-08	1014	94	20	int:YWHAB
Interaction	YWHAH interactions	MICALL1 TICRR SH3PXD2B SASH1 PIK3C2B MAPT SRGAP1 RPS6KA1 SH3D19 KDM3B MIEF1 SPIRE1 AKAP11 MAP7 PRAG1 DENND1A TRAPPC9 TNS3 SH3BP4 ANKS1A	1.36e-07	1102	94	20	int:YWHAH
Interaction	TOP3B interactions	TAOK2 MICALL1 HIVEP3 USP10 SH3PXD2B TRIB3 PIK3C2B CASKIN1 RECQL5 AOC2 KIAA0319L KDM3B RAPGEF1 ACIN1 SPIRE1 KDM6B PRAG1 DENND1A HCFC1 TRAPPC9 RAI1 SYMPK SH3BP4	1.91e-07	1470	94	23	int:TOP3B
Interaction	YWHAQ interactions	TICRR SASH1 ARHGAP23 PIK3C2B MAPT SRGAP1 RPS6KA1 SH3D19 MIEF1 SPIRE1 AKAP11 CDC5L MAP7 ZHX2 DENND1A MAP3K1 TNS3 SH3BP4 ANKS1A	8.02e-07	1118	94	19	int:YWHAQ
Interaction	YWHAE interactions	TAOK2 MICALL1 TICRR SASH1 PIK3C2B MAPT SRGAP1 SH3D19 MIEF1 SPIRE1 AKAP11 CDC5L MAP7 PRAG1 DENND1A SAP130 METAP2 MAP3K1 SH3BP4 ANKS1A	1.08e-06	1256	94	20	int:YWHAE
Interaction	YWHAZ interactions	MICALL1 TICRR SASH1 PIK3C2B MAPT CAMK2B SRGAP1 SH3D19 MIEF1 SPIRE1 AKAP11 CDC5L MAP7 ZHX2 DENND1A PIAS1 MAP3K1 PPP1CC SH3BP4 ANKS1A	2.30e-06	1319	94	20	int:YWHAZ
Interaction	SFN interactions	SASH1 NSFL1C PIK3C2B MAPT SH3D19 MIEF1 SPIRE1 AKAP11 DENND1A PIAS1 SAP130 TNS3 SH3BP4 ANKS1A	3.82e-06	692	94	14	int:SFN
Interaction	MAPRE3 interactions	TAOK2 SH3PXD2B GAS2L3 GAS2L2 MAPT SH3D19 APC2 MAP7	1.22e-05	230	94	8	int:MAPRE3
Interaction	TOP1 interactions	CDK8 ERCC6 SNW1 RBBP6 RECQL5 ACIN1 CDC5L PIAS1 HCFC1 GATAD2B RAI1 SYMPK PPP1CC	2.04e-05	696	94	13	int:TOP1
Interaction	GRB2 interactions	SH3PXD2B TRIB3 PIK3C2B MAPT RBBP6 RPS6KA1 SH3D19 RAPGEF1 E2F2 HUNK PRAG1 MAP3K1 PPP1CC TXK	2.14e-05	806	94	14	int:GRB2
Interaction	KLHL26 interactions	KLHL3 ACIN1 PHF8 NPAS1 ANKS1A	3.01e-05	77	94	5	int:KLHL26
Interaction	MAP2K7 interactions	SNW1 MAPT RPS6KA1 MAP3K13 CDC5L MAP3K1 NPAS1	3.83e-05	197	94	7	int:MAP2K7
Interaction	H3-3A interactions	ERCC6 MAPT RECQL5 KDM3B CHD2 PHF8 KDM6B PIAS1 SAP130 METAP2 HCFC1 GATAD2B RAI1	4.37e-05	749	94	13	int:H3-3A
Interaction	GSK3B interactions	NSFL1C TRIB3 MAPT RPS6KA1 AKAP11 ZDBF2 MAP7 PIAS1 MAP3K1 TNS3 RAI1 RCAN2 PPP1CC ANKS1A	4.81e-05	868	94	14	int:GSK3B
Interaction	AR interactions	CDK8 BCL9L USP10 SNW1 TRIB3 RPS6KA1 KDM3B ACIN1 CDC5L PIAS1 SAP130 HCFC1 GATAD2B RAI1 SYMPK	5.25e-05	992	94	15	int:AR
Interaction	GSK3A interactions	SNW1 MAPT ACIN1 AKAP11 ZDBF2 MAP7 TNS3 RCAN2 PPP1CC ANKS1A	6.11e-05	464	94	10	int:GSK3A
Interaction	MISP interactions	SNW1 TRIB3 RPS6KA1 RUSC1 NPAS1 PPP1CC	1.19e-04	164	94	6	int:MISP
Interaction	RBBP7 interactions	ERCC6 SNW1 MAPT CDC5L ZHX2 SAP130 HCFC1 GATAD2B SYMPK PPP1CC	1.27e-04	507	94	10	int:RBBP7
Interaction	ZBTB7C interactions	CDC5L PIAS1 GATAD2B	1.42e-04	22	94	3	int:ZBTB7C
Interaction	DTX2 interactions	BCL9L TRIB3 KIAA0319L SLITRK5 RUSC1 PIAS1 RAI1 SH3BP4	1.56e-04	330	94	8	int:DTX2
Interaction	DHX40 interactions	SNW1 RBBP6 RPS6KA1 ZDBF2 CDC5L PHF8 RAI1	1.66e-04	249	94	7	int:DHX40
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 MAP3K13 MAP3K1	5.44e-05	24	56	3	654
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM3B PHF8 KDM6B	5.44e-05	24	56	3	485
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP23 SRGAP1 OPHN1	4.98e-04	50	56	3	721
GeneFamily	Sterile alpha motif domain containing	SASH1 CASKIN1 ANKS1A	2.56e-03	88	56	3	760
Coexpression	GSE16450_CTRL_VS_IFNA_12H_STIM_MATURE_NEURON_CELL_LINE_DN	GAS2L3 KIAA0319L E2F2 HCFC1 TNS3 RCAN2 CYBA	8.49e-06	200	95	7	M7412
ToppCell	Control-Myeloid-Monocyte-derived_macrophages\|Control / group, cell type (main and fine annotations)	THEMIS2 SH3PXD2B GAS2L3 SRGAP1 RAPGEF1 DENND1A	3.65e-06	193	95	6	a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	THEMIS2 SH3PXD2B GAS2L3 RAPGEF1 DENND1A TNS3	3.87e-06	195	95	6	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAPT SRGAP1 APC2 CNGB1 TNS3 RCAN2	4.23e-06	198	95	6	b58138581f1a9073267d64c1211c5b9b4de71d3e
ToppCell	Adult-Immune\|Adult / Lineage, Cell type, age group and donor	THEMIS2 SH3PXD2B RAPGEF1 DENND1A APBB1IP CYBA	4.23e-06	198	95	6	9bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THEMIS2 SH3PXD2B GAS2L3 SRGAP1 DENND1A TNS3	4.23e-06	198	95	6	c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAPT CAMK2B SRGAP1 APC2 CNGB1 RCAN2	4.35e-06	199	95	6	b4824d3683a4e3025b8e74a0f1755b331b2a0ba7
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 SRGAP1 NAV3 APBB1IP TNS3 CYBA	4.48e-06	200	95	6	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 SRGAP1 NAV3 APBB1IP TNS3 CYBA	4.48e-06	200	95	6	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 SRGAP1 NAV3 APBB1IP TNS3 CYBA	4.48e-06	200	95	6	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 SRGAP1 NAV3 APBB1IP TNS3 CYBA	4.48e-06	200	95	6	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 SRGAP1 NAV3 APBB1IP TNS3 CYBA	4.48e-06	200	95	6	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	HIVEP3 SRGAP1 NAV3 APBB1IP TNS3 CYBA	4.48e-06	200	95	6	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RECQL5 MIEF1 PRAG1 SAP130 GATAD2B	3.20e-05	170	95	5	070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MRPS18A TIPIN IPO13 MAEL MAP7	3.20e-05	170	95	5	12aa9bdb18f3bf6da2a25984d08fe9497e5570ed
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GAS2L2 PHF8 C2orf81 CNGB1 FOXJ1	3.29e-05	171	95	5	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	facs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE6H CASKIN1 C11orf96 IRAG1 RCAN2	4.31e-05	181	95	5	429df38438d5a7ff490c9ede34b69e2970c7ded2
ToppCell	facs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE6H CASKIN1 C11orf96 IRAG1 RCAN2	4.31e-05	181	95	5	395cf5aa2d89b05328ab516b8c89401020b6d830
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SASH1 GAS2L3 HUNK MAP3K1 TNS3	4.31e-05	181	95	5	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	droplet-Liver-Npc-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 SRGAP1 NYNRIN C11orf96 TNS3	4.42e-05	182	95	5	dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SASH1 GAS2L3 HUNK MAP3K1 TNS3	4.42e-05	182	95	5	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 SRGAP1 NYNRIN C11orf96 TNS3	4.42e-05	182	95	5	010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 SRGAP1 NYNRIN C11orf96 TNS3	4.42e-05	182	95	5	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KLHL3 SPIRE1 HUNK OPHN1 SH3BP4	4.91e-05	186	95	5	d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCell	Control-Myeloid-Transitioning_MDM\|Control / group, cell type (main and fine annotations)	THEMIS2 SH3PXD2B SRGAP1 RAPGEF1 DENND1A	5.43e-05	190	95	5	d6fd8c23cde4a10cc1517b6899a5a855fdfff2e2
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	GAS2L3 C11orf96 MAP3K1 NPAS1 SH3BP4	5.43e-05	190	95	5	842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL6A3 SH3PXD2B SASH1 SRGAP1 OPHN1	5.56e-05	191	95	5	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	THEMIS2 SH3PXD2B GAS2L3 APBB1IP TNS3	5.70e-05	192	95	5	bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 HUNK MAP7 RCAN2 SH3BP4	5.70e-05	192	95	5	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP1 C11orf96 KDM6B ZHX2 PRAG1	5.70e-05	192	95	5	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 PIK3C2B MAPT SRGAP1 NYNRIN	5.84e-05	193	95	5	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RAPGEF1 ZHX2 DENND1A TRAPPC9 TNS3	5.84e-05	193	95	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 PIK3C2B MAPT SRGAP1 NYNRIN	5.84e-05	193	95	5	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HIVEP3 COL6A3 SRGAP1 SH3D19 NAV3	5.84e-05	193	95	5	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 PIK3C2B MAPT SRGAP1 NYNRIN	5.84e-05	193	95	5	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HIVEP3 COL6A3 SRGAP1 SH3D19 NAV3	5.99e-05	194	95	5	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	THEMIS2 GAS2L3 RAPGEF1 TNS3 CYBA	5.99e-05	194	95	5	69cf7c989ac355c459db13f9d4267b55adc3c174
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KLHL3 COL6A3 SH3D19 NAV3 SLITRK5	5.99e-05	194	95	5	99577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCell	Immune-alveolar_macrophage_(MARCO_positive)\|World / Lineage, Cell type, age group and donor	THEMIS2 GAS2L3 RAPGEF1 TNS3 CYBA	6.14e-05	195	95	5	f92114ef995e690a3bedc62c89c5fd6773d0d9f7
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	THEMIS2 SH3PXD2B DENND1A APBB1IP TNS3	6.14e-05	195	95	5	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	Adult-Immune-monocyte\|Adult / Lineage, Cell type, age group and donor	THEMIS2 RAPGEF1 DENND1A APBB1IP MAP3K1	6.29e-05	196	95	5	3ef193c5180de3137daf886492e74fc574bc9767
ToppCell	Children_(3_yrs)-Immune\|Children_(3_yrs) / Lineage, Cell type, age group and donor	THEMIS2 RAPGEF1 DENND1A APBB1IP CYBA	6.44e-05	197	95	5	f18807124b91310fcd84238484a80ecdba684679
ToppCell	Immune\|World / Lineage, Cell type, age group and donor	THEMIS2 RAPGEF1 DENND1A APBB1IP CYBA	6.60e-05	198	95	5	65681b54d13c6997bd90a1c2a12314a80e964fe3
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAPT CAMK2B APC2 CNGB1 RCAN2	6.60e-05	198	95	5	7b9c7ce5d6b7df8db85943b65da1a2c202a8bb53
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	THEMIS2 GAS2L3 RBBP6 KDM6B TNS3	6.60e-05	198	95	5	93cc01d91ffc543fd1a717ef47e02e532b50b665
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A3 C11orf96 AIRE IRAG1 RCAN2	6.60e-05	198	95	5	b7e900fc0a1b3fa5e47dcc36ce6b0c3ce6bf9739
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	MAPT CAMK2B SRGAP1 C11orf96 SLITRK5	6.60e-05	198	95	5	60d8d3bbd754ffde41c50013d822667b185a9751
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THEMIS2 RAPGEF1 DENND1A APBB1IP MAP3K1	6.75e-05	199	95	5	ac866ae110967c5867ff4601939b79861d43df54
ToppCell	Children_(3_yrs)-Immune-monocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	THEMIS2 SH3PXD2B DENND1A APBB1IP MAP3K1	6.92e-05	200	95	5	881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THEMIS2 SH3PXD2B GAS2L3 SRGAP1 DENND1A	6.92e-05	200	95	5	ad52b38df5c71f28829b04cd0e6b97f0f9f7610a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	MAPT CAMK2B C11orf96 KDM6B GATAD2B	6.92e-05	200	95	5	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	THEMIS2 RAPGEF1 DENND1A APBB1IP MAP3K1	6.92e-05	200	95	5	fc061de0db2e8b5ca47f5e2a1e861018e7f1b582
Disease	neuroimaging measurement	TAOK2 MAPT SKIDA1 NAV3 MAEL CDC5L IRAG1 ZHX2 DENND1A METAP2 SZRD1 GATAD2B MAP3K1 RAI1 FOXJ1 ANKS1A	2.55e-07	1069	94	16	EFO_0004346
Disease	prostate carcinoma	MRPS18A RPF1 COL6A3 SH3PXD2B PIK3C2B DTX4 SH3D19 ARMC2 GATAD2B MAP3K1 TNS3 OPHN1	2.63e-05	891	94	12	EFO_0001663
Disease	Akathisia	MAPT RAI1	6.00e-05	4	94	2	C0392156
Disease	Psychomotor Agitation	MAPT RAI1	6.00e-05	4	94	2	C3887612
Disease	Growth Disorders	SH3PXD2B ERCC6 RAI1	2.07e-04	36	94	3	C0018273
Disease	hearing impairment	CDK8 SH3PXD2B ERCC6 MYO15A	2.77e-04	98	94	4	C1384666
Disease	Intellectual Disability	CDK8 CAMK2B APC2 KDM3B ACIN1 KDM6B RAI1	5.76e-04	447	94	7	C3714756
Disease	cortical thickness	MICALL1 SH3PXD2B MAPT NAV3 MAEL CDC5L IRAG1 DENND1A GATAD2B MAP3K1 ANKS1A	8.27e-04	1113	94	11	EFO_0004840
Disease	eosinophil count	THEMIS2 HIVEP3 SH3PXD2B TRIB3 PIK3C2B MAPT E2F2 KDM6B PIAS1 APBB1IP RAI1 SYMPK PPP1CC	8.65e-04	1488	94	13	EFO_0004842
Disease	cortical surface area measurement	TICRR MAPT SKIDA1 NAV3 MAEL CDC5L IRAG1 DENND1A METAP2 GATAD2B MAP3K1 ANKS1A	1.16e-03	1345	94	12	EFO_0010736
Disease	Abnormal behavior	CDK8 KDM3B	1.17e-03	16	94	2	C0233514
Disease	coronary artery disease	CDK8 COL6A3 RPS6KA1 CHD2 IRAG1 SAP130 MAP3K1 TNS3 RAI1 OPHN1 ANKS1A	1.46e-03	1194	94	11	EFO_0001645
Disease	primary ciliary dyskinesia (implicated_via_orthology)	GAS2L2 FOXJ1	1.66e-03	19	94	2	DOID:9562 (implicated_via_orthology)
Disease	asthma, endometriosis	TMPRSS7 PRAG1 SYMPK	1.72e-03	74	94	3	EFO_0001065, MONDO_0004979
Disease	brain measurement, neuroimaging measurement	SKIDA1 NAV3 MAEL METAP2 GATAD2B MAP3K1 ANKS1A	1.91e-03	550	94	7	EFO_0004346, EFO_0004464
Disease	response to anticonvulsant	COL6A3 SASH1 NAV3	2.56e-03	85	94	3	GO_0036277
Disease	information processing speed	SASH1 TRIB3 MAPT	2.56e-03	85	94	3	EFO_0004363
Disease	systemic scleroderma, systemic lupus erythematosus	KIAA0319L ANKS1A	3.10e-03	26	94	2	EFO_0000717, MONDO_0007915
Disease	lip morphology measurement	RBBP6 SH3D19 NAV3 METAP2	3.17e-03	189	94	4	EFO_0007845

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVRTAQVPSPPRGKI	ACIN1	996	Q9UKV3
PKPVINSTPGRTPLR	CDC5L	431	Q99459
PKPPVDPAKIRRVSN	ARMC2	116	Q8NEN0
PAVAKRPPVPPKRQE	APBB1IP	621	Q7Z5R6
PALPANVRKPTPRKP	AKAP11	406	Q9UKA4
PKPRVGVRKSALEPP	ANKS1A	1091	Q92625
VTRKNMPPPGVVKLP	DTX4	216	Q9Y2E6
NKRAARKAPAPVTPP	ERCC6	291	Q03468
LSQPRKGRKPPAVPK	AIRE	106	O43918
PKIIQTRRPGLPPSV	RCAN2	181	Q14206
VPEAPIAKKEPVPRG	RAI1	981	Q7Z5J4
SKVRPPGEKPTIIRP	OPHN1	726	O60890
PQTQGKRIKVEPGPR	NPAS1	456	Q99742
KSGRLEVVRVPLPPP	AOC2	276	O75106
NKRAARKAPAPVTPP	ERCC6	291	P0DP91
TEKPPPPARVQLVRA	HCFC1	361	P51610
IKRASVPPVPGKPRQ	CASKIN1	751	Q8WXD9
PSEKQKPVFTPLRRP	MAEL	71	Q96JY0
KRGPKVQTDPPSVPI	METAP2	106	P50579
VRPPSPGNIRPVKRE	MAP7	361	Q14244
SEPPTRAVKPQVRLP	MYO15A	876	Q9UKN7
VTVKPEPRKNRPPIA	KIAA0319L	396	Q8IZA0
EPRKNRPPIAIVSPQ	KIAA0319L	401	Q8IZA0
KRGGPPVKRAAEPPV	KDM6B	191	O15054
PKPRERPQIGGTIKQ	CYBA	136	P13498
QRKVSQGRLAPRPPP	IRAG1	256	Q9Y6F6
QGRLAPRPPPVEKSK	IRAG1	261	Q9Y6F6
SQKKPTRLPGPSRVP	NAV3	241	Q8IVL0
QRKITRPSQRPKTPP	KIR3DL3	391	Q8N743
PKGRPRTAPLKVGQS	KDM3B	866	Q7LBC6
KASPEARPQIPTKPR	MICALL1	271	Q8N3F8
ARPQIPTKPRVPGKL	MICALL1	276	Q8N3F8
CPPRPKPVARKGQVD	MIEF1	111	Q9NQG6
QRGPPKPGLVRTTTP	GATAD2B	276	Q8WXI9
RSGQQIVGPPRKKSP	NSFL1C	101	Q9UNZ2
TGYTKRLRKQLPPPP	RBBP6	326	Q7Z6E9
GKPVARSKTMPPQVP	PIK3C2B	271	O00750
GTPPALPRKTRPLQK	MAP3K13	796	O43283
KGTPGPRATPRKVAP	APC2	1806	O95996
RPVVPEFPTPKGKCI	E2F2	96	Q14209
VPRRTVPKPRVKKQP	CHD2	181	O14647
PVQGLTKIPIRLPPA	GAS2L2	496	Q8NHY3
PVSIPKSKEKQGRPP	GAS2L3	336	Q86XJ1
VVGEPLPIPRIKRPN	DGAT2L6	286	Q6ZPD8
RPPVAVKPATAAKPV	COL6A3	2931	P12111
PRTPRIVKKPEPHQP	HUNK	526	P57058
VPRAKLDQAPKVPPT	BCL9L	271	Q86UU0
QPLPKRVAKVPRPPS	FOXJ1	276	Q92949
RPQGRKTPELGIVPP	DENND1A	701	Q8TEH3
IKNPRTKPRTPVSLP	KLHL3	286	Q9UH77
RSKAEKVRPPTVPVP	C2orf81	16	A6NN90
TQGPPLKKVRVVPPT	CDK8	396	P49336
RKLPVPQGPNPVVVV	IPO13	666	O94829
KAPAAPKVPVTPRVS	NYNRIN	661	Q9P2P1
NRRGPVVVKPIPVKG	MAP3K1	206	Q13233
VPPRRKKNRPGLQPI	RUSC1	406	Q9BVN2
VRVPKPIPLPGVRNI	RTL5	311	Q5HYW3
PPPQIRILKRPTSNG	SZRD1	56	Q7Z422
PGPLPTPSRKQEIIK	CAMK2B	526	Q13554
RPKPAVLPKTNPTIG	SRGAP1	1056	Q7Z6B7
APTRKPTVIRIPAKP	SH3D19	251	Q5HYK7
PPPKSAIKPSGQRRF	SH3BP4	611	Q9P0V3
GLQALRPPQVTPPRK	PRR36	276	Q9H6K5
PGLPKPQATVPRKVD	GPR108	151	Q9NPR9
LGKRPVLQTPPVKPN	SKIDA1	786	Q1XH10
HRPRLPEGVVPKSKP	MRPS18A	131	Q9NVS2
KSLKVRAGQRPPGLP	TAOK2	741	Q9UL54
PTKNGVEPKRPSRPI	PIAS1	236	O75925
GSREPKQPQPLLRKP	TNS3	556	Q68CZ2
PTTPRKGPPKFKQRQ	PDE6H	16	Q13956
QRVLPQPPGTPRKTK	CNGB1	6	Q14028
EFPQPVRPAKLPKGR	C11orf96	341	Q7Z7L8
QPQKRPRPSAKPSVV	RECQL5	866	O94762
APPKPVPKTIDNQRV	RPF1	96	Q9H9Y2
KTPRTPKRQGTQPPG	TICRR	1191	Q7Z2Z1
LPPKKRQSAPSPTRV	RAPGEF1	286	Q13905
RPPCVSVKISPKGVP	SARG	571	Q9BW04
PKGTRQPNKPRVRPT	SLITRK5	331	O94991
SAQKKLPVRRPPLPG	TMPRSS7	26	Q7RTY8
PQNPFLKSRPQVRPK	SH3PXD2B	631	A1X283
LKSRPQVRPKPAPSP	SH3PXD2B	636	A1X283
LNPVSARKLKPTPPR	SPIRE1	351	Q08AE8
VQKRARSGPQPRLPP	TRIB3	31	Q96RU7
LRQKPPTGRKVQLTP	ARHGAP23	491	Q9P227
PPRPPKNQGLSKQRR	THEMIS2	551	Q5TEJ8
LPPGASPRKKPRKQQ	SAP130	826	Q9H0E3
PKVFVPRPSQVSLKP	HIVEP3	161	Q5T1R4
PPAERPPKQKGRVAS	ZDBF2	1921	Q9HCK1
PSQPPPVPAKKSRER	SASH1	981	O94885
AAPRGKPVSRVPQLK	MAPT	361	P10636
PTREPKKVAVVRTPP	MAPT	536	P10636
RFKINKKIPRGPPSP	SNW1	211	Q13573
QPPPLPQKKIVSRAA	PRAG1	811	Q86YV5
KKKPNATRPVTPPRG	PPP1CC	301	P36873
APQAKRRPEPIIPVT	SYMPK	516	Q92797
KRPLVTPQAAPEPKR	ZHX2	406	Q9Y6X8
TGRVQPSKRKPLPPL	TXK	61	P42681
PVPPKPRQALGDKIV	USP10	476	Q14694
PKARVTPTLPKQDRP	PHF8	881	Q9UPP1
QVVRPRVEGKPVNPP	TRAPPC9	826	Q96Q05
PVRVPPKRTVKRNIP	TIPIN	51	Q9BVW5
RREIKPPFKPAVAQP	RPS6KA1	331	Q15418