Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

DDX49 MYO7A TOMM20 DDX56 CHD8 CHD7 DNAH1 BLM MSH6 IQCA1L IQCA1 CHD5 AFG3L2 ABCD4 CHD6 KIF3C ABCD2 ATP2A1

2.20e-0761413718GO:0140657
GeneOntologyMolecularFunctionATP hydrolysis activity

DDX49 DDX56 CHD8 CHD7 BLM IQCA1L IQCA1 CHD5 AFG3L2 ABCD4 CHD6 KIF3C ABCD2 ATP2A1

2.14e-0644113714GO:0016887
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

DDX49 DDX56 CHD8 CHD7 DRG1 BLM IQCA1L EEF2 IQCA1 CHD5 AFG3L2 ABCD4 EIF5B IRGC CHD6 KIF3C ABCD2 ATP2A1

6.06e-0677513718GO:0017111
GeneOntologyMolecularFunctionpyrophosphatase activity

DDX49 DDX56 CHD8 CHD7 DRG1 BLM IQCA1L EEF2 IQCA1 CHD5 AFG3L2 ABCD4 EIF5B IRGC CHD6 KIF3C ABCD2 ATP2A1

1.77e-0583913718GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

DDX49 DDX56 CHD8 CHD7 DRG1 BLM IQCA1L EEF2 IQCA1 CHD5 AFG3L2 ABCD4 EIF5B IRGC CHD6 KIF3C ABCD2 ATP2A1

1.80e-0584013718GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

DDX49 DDX56 CHD8 CHD7 DRG1 BLM IQCA1L EEF2 IQCA1 CHD5 AFG3L2 ABCD4 EIF5B IRGC CHD6 KIF3C ABCD2 ATP2A1

1.80e-0584013718GO:0016818
GeneOntologyMolecularFunctiondephospho-CoA kinase activity

DCAKD COASY

4.67e-0521372GO:0004140
GeneOntologyMolecularFunctionhistone binding

NAP1L2 CHD8 CHD7 DTX3L MSH6 CHD5 ANP32A CHD6 ANP32D

9.11e-052651379GO:0042393
GeneOntologyMolecularFunctionhelicase activity

DDX49 DDX56 CHD8 CHD7 BLM CHD5 CHD6

1.11e-041581377GO:0004386
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD8 CHD7 CHD5 CHD6

1.17e-04371374GO:0140658
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

CHD8 CHD7 BLM MSH6 CHD5 CHD6

2.45e-041271376GO:0008094
GeneOntologyMolecularFunctionHLA-A specific inhibitory MHC class I receptor activity

LILRA1 LILRB1

4.61e-0451372GO:0030107
GeneOntologyMolecularFunctionHLA-B specific inhibitory MHC class I receptor activity

LILRA1 LILRB1

6.88e-0461372GO:0030109
GeneOntologyMolecularFunctionMHC class Ib protein complex binding

LILRA1 LILRB1

9.59e-0471372GO:0023025
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

DCAKD FLT4 PIK3CB ULK4 AKT2 EIF2AK4 ATM PRKG2 COASY LYN HCK IP6K2 AURKB

1.20e-0370913713GO:0016773
DomainP-loop_NTPase

DCAKD DDX49 MYO7A SPEF2 DDX56 CHD8 CHD7 DNAH1 DRG1 BLM MSH6 EEF2 MYO15B IQCA1 CHD5 AFG3L2 ABCD4 EIF5B IRGC CHD6 KIF3C COASY ABCD2 NLRP4

8.69e-0984813524IPR027417
Domain-

DCAKD DDX49 MYO7A SPEF2 DDX56 CHD8 CHD7 DNAH1 DRG1 BLM MSH6 EEF2 IQCA1 CHD5 AFG3L2 ABCD4 EIF5B IRGC CHD6 COASY ABCD2 NLRP4

1.90e-08746135223.40.50.300
DomainARM-type_fold

DOCK2 MROH2A USP24 HEATR1 ARMCX1 DOCK5 RIF1 IFRD1 MROH1 PIK3CB MROH7 ULK4 UTP20 ATM

1.70e-0733913514IPR016024
DomainARM-like

DOCK2 MROH2A HEATR1 ARMCX1 RIF1 IFRD1 MROH1 CEP70 MROH7 ULK4 UTP20

4.32e-0627013511IPR011989
DomainDNA/RNA_helicase_DEAH_CS

CHD8 CHD7 BLM CHD5 CHD6

5.00e-06351355IPR002464
DomainBRK

CHD8 CHD7 CHD6

7.27e-0661353SM00592
DomainBRK_domain

CHD8 CHD7 CHD6

7.27e-0661353IPR006576
DomainBRK

CHD8 CHD7 CHD6

7.27e-0661353PF07533
DomainDEAH_ATP_HELICASE

CHD8 CHD7 BLM CHD5 CHD6

7.59e-06381355PS00690
DomainHEAT_REPEAT

MROH2A HEATR1 MROH1 MROH7 ULK4 UTP20

1.14e-05701356PS50077
DomainHelicase_C

DDX49 DDX56 CHD8 CHD7 BLM CHD5 CHD6

1.26e-051071357PF00271
DomainHELICc

DDX49 DDX56 CHD8 CHD7 BLM CHD5 CHD6

1.26e-051071357SM00490
DomainHelicase_C

DDX49 DDX56 CHD8 CHD7 BLM CHD5 CHD6

1.34e-051081357IPR001650
DomainHELICASE_CTER

DDX49 DDX56 CHD8 CHD7 BLM CHD5 CHD6

1.42e-051091357PS51194
DomainHELICASE_ATP_BIND_1

DDX49 DDX56 CHD8 CHD7 BLM CHD5 CHD6

1.42e-051091357PS51192
DomainDEXDc

DDX49 DDX56 CHD8 CHD7 BLM CHD5 CHD6

1.42e-051091357SM00487
DomainHelicase_ATP-bd

DDX49 DDX56 CHD8 CHD7 BLM CHD5 CHD6

1.51e-051101357IPR014001
DomainChromo_domain

CHD8 CHD7 CHD5 CHD6

2.48e-05241354IPR023780
DomainChromo

CHD8 CHD7 CHD5 CHD6

3.45e-05261354PF00385
DomainCHROMO_1

CHD8 CHD7 CHD5 CHD6

4.67e-05281354PS00598
DomainCHROMO_2

CHD8 CHD7 CHD5 CHD6

4.67e-05281354PS50013
DomainDPCK

DCAKD COASY

5.19e-0521352PS51219
DomainArp1

ACTR1B ACTR1A

5.19e-0521352IPR029909
DomainDepp_CoAkinase

DCAKD COASY

5.19e-0521352IPR001977
DomainCoaE

DCAKD COASY

5.19e-0521352PF01121
DomainSNF2_N

CHD8 CHD7 CHD5 CHD6

8.02e-05321354IPR000330
DomainSNF2_N

CHD8 CHD7 CHD5 CHD6

8.02e-05321354PF00176
DomainChromodomain-like

CHD8 CHD7 CHD5 CHD6

8.02e-05321354IPR016197
DomainChromo/shadow_dom

CHD8 CHD7 CHD5 CHD6

9.08e-05331354IPR000953
DomainCHROMO

CHD8 CHD7 CHD5 CHD6

9.08e-05331354SM00298
DomainMethyltransf_32

GSTCD METTL25

1.55e-0431352PF13679
DomainSH3

DOCK2 MYO7A SPTA1 STAC DOCK5 MYO15B LYN HCK

1.77e-042161358SM00326
DomainSH3

DOCK2 MYO7A SPTA1 STAC DOCK5 MYO15B LYN HCK

1.77e-042161358PS50002
DomainSH3_domain

DOCK2 MYO7A SPTA1 STAC DOCK5 MYO15B LYN HCK

2.01e-042201358IPR001452
Domain-

HEATR1 ARMCX1 RIF1 IFRD1 MROH1 MROH7 ULK4 UTP20

2.13e-0422213581.25.10.10
DomainABC_membrane_2

ABCD4 ABCD2

3.08e-0441352PF06472
DomainDOCK_N

DOCK2 DOCK5

5.11e-0451352PF16172
DomainDOCK_N

DOCK2 DOCK5

5.11e-0451352IPR032376
DomainGlyco_trans_1

GTDC1 ALG2

1.06e-0371352IPR001296
DomainGlycos_transf_1

GTDC1 ALG2

1.06e-0371352PF00534
DomainMethyltranfer_dom

GSTCD METTL25

1.41e-0381352IPR025714
DomainMYTH4

MYO7A MYO15B

1.81e-0391352PS51016
DomainMyTH4

MYO7A MYO15B

1.81e-0391352SM00139
DomainMyTH4_dom

MYO7A MYO15B

1.81e-0391352IPR000857
DomainMyTH4

MYO7A MYO15B

1.81e-0391352PF00784
DomainKinase-like_dom

FLT4 PDCD6IP PIK3CB ULK4 AKT2 EIF2AK4 ATM PRKG2 LYN HCK AURKB

1.95e-0354213511IPR011009
DomainMKP

DUSP6 DUSP10

2.25e-03101352IPR008343
DomainDHR-1_domain

DOCK2 DOCK5

2.73e-03111352IPR027007
DomainDHR_2

DOCK2 DOCK5

2.73e-03111352PS51651
DomainDHR_1

DOCK2 DOCK5

2.73e-03111352PS51650
DomainDHR-2

DOCK2 DOCK5

2.73e-03111352PF06920
DomainDOCK

DOCK2 DOCK5

2.73e-03111352IPR026791
DomainDOCK_C

DOCK2 DOCK5

2.73e-03111352IPR010703
DomainDOCK-C2

DOCK2 DOCK5

2.73e-03111352PF14429
DomainDHR-2

DOCK2 DOCK5

2.73e-03111352IPR027357
DomainLipid-bd_serum_glycop_C

BPIFB3 BPIFA2

3.26e-03121352IPR001124
DomainLBP_BPI_CETP

BPIFB3 BPIFA2

3.84e-03131352PF01273
DomainBPI/LBP/Plunc

BPIFB3 BPIFA2

3.84e-03131352IPR032942
DomainBactericidal_perm-incr_a/b_dom

BPIFB3 BPIFA2

3.84e-03131352IPR017943
DomainLipid-bd_serum_glycop_N

BPIFB3 BPIFA2

3.84e-03131352IPR017942
DomainHEAT

HEATR1 MROH1 UTP20

5.04e-03481353PF02985
DomainPI3/4_kinase_CS

PIK3CB ATM

5.12e-03151352IPR018936
DomainSpectrin_alpha_SH3

SPTA1 STAC

5.12e-03151352IPR013315
DomainSANT

CHD7 MIDEAS CHD6

5.65e-03501353SM00717
DomaincNMP-bd_CS

PRKG2 CNGA3

5.82e-03161352IPR018488
Domain-

PIK3CB ATM

5.82e-031613521.10.1070.11
DomainPI3Kc

PIK3CB ATM

5.82e-03161352SM00146
DomainActin_CS

ACTR1B ACTR1A

5.82e-03161352IPR004001
DomainSANT/Myb

CHD7 MIDEAS CHD6

6.30e-03521353IPR001005
DomainACTINS_2

ACTR1B ACTR1A

6.57e-03171352PS00432
DomainSH3_1

SPTA1 STAC DOCK5 LYN HCK

6.82e-031641355PF00018
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DOCK2 PDCD6IP USP24 CHD8 CHD7 DRG1 BLM DOCK5 SART1 ACTR1A MSH6 RIF1 MYO15B LRRC1 ATM CNOT1 AURKB

2.09e-105821391720467437
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

DOCK2 PDCD6IP SPTA1 COQ6 CHD8 ALDH1L1 GFPT1 DNAH1 ACTR1A MSH6 NAA35 EEF2 LLGL2 EIF5B PSME3 UQCRC1 SPAG17 ATP2A1 CNOT1

6.24e-108071391930575818
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SETD1A DDX49 PDCD6IP DDX56 CHD8 CHD7 HEATR1 MIDEAS ARMCX1 GFPT1 BLM SART1 ACTR1B ACTR1A MSH6 RIF1 NAA35 EEF2 AFG3L2 EIF5B UTP20 PSME3 UQCRC1

4.51e-0913531392329467282
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PDCD6IP USP24 DDX56 CHD8 CHD7 HEATR1 GFPT1 BLM SART1 MSH6 RIF1 EIF5B UTP20 ATM UQCRC1 CNOT1

8.90e-096531391622586326
Pubmed

The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.

LILRA1 LILRB1 LYN HCK

1.69e-088139419255189
Pubmed

The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.

CHD8 CHD7 CHD6

6.25e-083139328533432
Pubmed

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.

ANP32A ATM ANP32D

2.49e-074139330209244
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

DCAKD CENPB MYO7A HEATR1 DRG1 BLM DOCK5 SART1 ACTR1B ACTR1A RIF1 CCDC88A AFG3L2 EIF5B KIF3C UQCRC1 PRKG2 METTL25 CNOT1 AURKB

3.26e-0713211392027173435
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TBRG4 PDCD6IP DDX56 HEATR1 GFPT1 DRG1 SART1 ACTR1A MSH6 RIF1 EEF2 ANP32A EIF5B UTP20 PSME3 KIF3C ATM UQCRC1 COASY CNOT1

1.06e-0614251392030948266
Pubmed

Hereditary Ataxia Overview

ATN1 EEF2 VPS13D SACS AFG3L2 ATM

1.97e-0692139620301317
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SETD1A USP24 CHD8 HEATR1 MIDEAS MBIP DHRS7B MSH6 NFKBIE ARPIN PSME3 CNOT1

2.30e-065491391238280479
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

DDX49 PDCD6IP DDX56 CHD8 HEATR1 MIDEAS MSH6 RIF1 PSME3 ATM

2.60e-063701391022922362
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PDCD6IP CHD7 DNAH1 CHD5 CHD6 EIF2AK4 FAM135A

2.92e-06153139710718198
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

PDCD6IP COQ6 GFPT1 ACTR1B ACTR1A SYNJ2 ANP32A ARPIN PSME3 UQCRC1 ANP32D ATP2A1 CNOT1

2.92e-066651391330457570
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SEC16B ATN1 USP24 CHD7 BLM SART1 MSH6 RIF1 ESYT2 EEF2 EIF5B UTP20 ATM COASY

2.94e-067741391415302935
Pubmed

The shieldin complex mediates 53BP1-dependent DNA repair.

DCAKD RIF1 ESYT2 AFG3L2 COASY

3.08e-0656139530022168
Pubmed

Defining the membrane proteome of NK cells.

DOCK2 DCAKD EPS15 PDCD6IP DDX56 HEATR1 ALG2 DHRS7B DRG1 ACTR1B ESYT2 EEF2 CDK5RAP3 CHD5 PSME3 M6PR CNOT1

4.55e-0611681391719946888
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SPEF2 SPTA1 COQ6 TOMM20 HEATR1 ALG2 DHRS7B SART1 EEF2 SACS CHD5 RETREG1 EIF5B CHD6 EIF2AK4 ATM METTL25 SPAG17 ATP2A1

5.04e-0614421391935575683
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

MYO7A MROH2A MIDEAS GFPT1 DNAH1 DOCK5 MSH6 IQCA1L LRRC1 MROH7 EIF5B

5.39e-064961391131343991
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

EPS15 PDCD6IP USP24 GFPT1 ESYT2 EEF2 CDK5RAP3 CCDC88A AFG3L2 EIF5B ARPIN CNOT1 FAM135A

5.75e-067081391339231216
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

EPS15 HEATR1 DRG1 BLM ESYT2 NAA35 CDK5RAP3 CCDC88A SACS PPP1R15B AFG3L2 LRRC1 RETREG1 EIF5B AKT2 ATM COASY M6PR FAM135A

7.79e-0614871391933957083
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DCAKD EPS15 CPAMD8 PDCD6IP DDX56 NSMCE2 NAALADL2 PLBD2 DHRS7B DNAH1 DOCK5 ESYT2 IFRD1 SYNJ2 LRRC1 CHD6 EIF2AK4 UQCRC1 CNOT1

7.94e-0614891391928611215
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

EPS15 DDX49 DDX56 CHD8 CHD7 HEATR1 DRG1 BLM ACTR1A MSH6 RIF1 ESYT2 IFRD1 CDK5RAP3 AFG3L2 EIF5B UTP20 CHD6 UQCRC1

8.57e-0614971391931527615
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SETD1A TBRG4 PDCD6IP CEP162 TOMM20 CHD8 CCDC88A SYNJ2 CHD5 EIF2AK4 CNOT1

9.86e-065291391114621295
Pubmed

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.

BLM MSH6 ATM

1.01e-0511139311877377
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

SETD1A DDX56 CHD8 MIDEAS DHRS7B DRG1 SART1 RIF1 EIF5B

1.01e-05341139932971831
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

PDCD6IP CHD8 GFPT1 DHRS7B DRG1 ACTR1A MSH6 ESYT2 AFG3L2 PSME3 CNOT1

1.08e-055341391135032548
Pubmed

Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus.

BPIFA2 LYN HCK

1.34e-051213932759422
Pubmed

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

BLM MSH6 ATM

1.34e-0512139310783165
Pubmed

Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.

LILRA1 LILRB1 LYN

1.34e-0512139310611342
Pubmed

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X.

PDCD6IP HCK

1.59e-052139220670214
Pubmed

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

LYN HCK

1.59e-052139226517880
Pubmed

Proteasome activator REGγ promotes inflammation in Leydig cells via IkBε signaling.

NFKBIE PSME3

1.59e-052139230816488
Pubmed

CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome.

CHD8 CHD7

1.59e-052139220453063
Pubmed

Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.

ACTR1B ACTR1A

1.59e-05213927696711
Pubmed

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.

DOCK2 DOCK5

1.59e-052139225339677
Pubmed

Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks.

ATM LYN

1.59e-052139225173936
Pubmed

Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survival.

PSME3 ATM

1.59e-052139221216954
Pubmed

Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.

BLM ATM

1.59e-052139212034743
Pubmed

Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.

CHD8 CHD7

1.59e-052139224211491
Pubmed

The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6.

BLM MSH6

1.59e-052139212974384
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

DOCK2 USP24 PDE8B AKT2 LYN HCK

1.65e-05133139615144186
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

PDCD6IP CENPB COQ6 USP24 TOMM20 PLBD2 GFPT1 DRG1 SART1 NAA35 EEF2 AFG3L2 EIF5B UQCRC1 LYN CNOT1 AURKB

1.77e-0512971391733545068
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DOCK5 MSH6 MROH7 EIF5B UTP20 EIF2AK4 CNOT1

1.79e-05202139733005030
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

DDX49 CHD8 CHD7 BLM SART1 MSH6 RIF1 PSME3

1.95e-05283139830585729
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

DCAKD CEP162 DUSP6 BLM MSH6 RIF1 ESYT2 CCDC88A CCNB2 AFG3L2 LRRC1 DUSP10 EIF2AK4 CNOT1 AURKB

2.11e-0510491391527880917
Pubmed

The protein interaction landscape of the human CMGC kinase group.

PDCD6IP DUSP6 ZMAT4 DRG1 SART1 ESYT2 EEF2 CCNB2 AFG3L2 LRRC1 PSME3 PRKG2

2.44e-056951391223602568
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

DCAKD TBRG4 PDCD6IP USP24 HEATR1 GFPT1 DHRS7B DRG1 ESYT2 NAA35 IFRD1 CCNB2 UTP20 AURKB

2.66e-059421391431073040
Pubmed

A human MAP kinase interactome.

PDCD6IP CHD8 MIDEAS RIF1 CCDC88A SYNJ2 CHD6 DUSP10 SLC4A4 HCK

2.77e-054861391020936779
Pubmed

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

PDCD6IP USP24 GFPT1 MSH6 ESYT2 AFG3L2 ATP2A1

2.84e-05217139730619736
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK2 SEC16B AMIGO1 GPD1L VPS13D MYO15B SACS EIF5B FAM135A UNC80

3.12e-054931391015368895
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

EPS15 TBRG4 USP24 CHD8 GFPT1 BLM MSH6 RIF1 EEF2 EIF5B

3.70e-055031391016964243
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

SETD1A DUSP6 USP24 LRP1B GFPT1 LLGL2 AKT2 PSME3 UQCRC1 LYN HCK AURKB

3.93e-057301391234857952
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CEP162 LRP1B GFPT1 ACTR1B ACTR1A ESYT2 CCDC66 CCDC88A SYNJ2 CCNB2 NFKBIE LYN CNOT1

4.04e-058531391328718761
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

PDCD6IP CENPB DTX3L GFPT1 ACTR1B ACTR1A MSH6 CNOT1

4.18e-05315139826777405
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

PDCD6IP DDX56 HEATR1 NSMCE2 MIDEAS BLM SART1 MSH6 RIF1 EEF2 ANP32A UTP20 UQCRC1 AURKB

4.50e-059891391436424410
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

PDCD6IP DDX56 HEATR1 GFPT1 DHRS7B DRG1 SART1 ACTR1A MSH6 EEF2 CHD5 AFG3L2 EIF5B UTP20 LYN AURKB

4.50e-0512571391636526897
Pubmed

Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.

LYN HCK

4.75e-053139210684859
Pubmed

USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.

BLM ATM

4.75e-053139234606619
Pubmed

Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn.

LYN HCK

4.75e-05313929151903
Pubmed

Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci.

ANP32A ANP32D

4.75e-05313928970164
Pubmed

Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals.

ANP32A ANP32D

4.75e-053139231213560
Pubmed

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.

LYN HCK

4.75e-053139217513616
Pubmed

PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis.

ANP32A ANP32D

4.75e-053139219121999
Pubmed

The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4.

LYN HCK

4.75e-053139216140274
Pubmed

SRC-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells.

LYN HCK

4.75e-053139214969582
Pubmed

HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.

LYN HCK

4.75e-053139216849330
Pubmed

ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia.

ANP32A ANP32D

4.75e-053139229269781
Pubmed

PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.

ANP32A ANP32D

4.75e-053139238421166
Pubmed

A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.

CCDC88A AKT2

4.75e-053139215753085
Pubmed

Identification of sequences required for inhibition of oncogene-mediated transformation by pp32.

ANP32A ANP32D

4.75e-053139210400610
Pubmed

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.

DOCK2 DOCK5

4.75e-053139224913231
Pubmed

DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.

DOCK2 DOCK5

4.75e-053139236804596
Pubmed

Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors.

LYN HCK

4.75e-053139217588471
Pubmed

Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells.

LYN HCK

4.75e-053139218346837
Pubmed

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.

CHD8 CHD7

4.75e-053139230108144
Pubmed

Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells.

LYN HCK

4.75e-053139210749872
Pubmed

Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.

LYN HCK

4.75e-053139211238661
Pubmed

Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.

ANP32A ANP32D

4.75e-053139236370958
Pubmed

Modulation of oncogenic potential by alternative gene use in human prostate cancer.

ANP32A ANP32D

4.75e-053139210086381
Pubmed

Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4.

LILRA1 LILRB1

4.75e-053139210941837
Pubmed

The expression and distributions of ANP32A in the developing brain.

ANP32A ANP32D

4.75e-053139225866766
Pubmed

Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.

LYN HCK

4.75e-053139211698501
Pubmed

The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.

CHD8 ATM

4.75e-053139234292326
Pubmed

Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.

LYN HCK

4.75e-053139222393415
Pubmed

Tumor suppression and potentiation by manipulation of pp32 expression.

ANP32A ANP32D

4.75e-053139211360199
Pubmed

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.

NFKBIE PSME3

4.75e-053139226899380
Pubmed

Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.

CHD8 CHD7

4.75e-053139230277262
Pubmed

The risk for developing cancer in Israeli ATM, BLM, and FANCC heterozygous mutation carriers.

BLM ATM

4.75e-053139226778106
Pubmed

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

LYN HCK

4.75e-053139225225462
Pubmed

ANP32A regulates histone H3 acetylation and promotes leukemogenesis.

ANP32A ANP32D

4.75e-053139229467488
Pubmed

Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors.

LYN HCK

4.75e-053139237089957
Pubmed

Generation and characterization of LANP/pp32 null mice.

ANP32A ANP32D

4.75e-053139215060138
Pubmed

Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.

LYN HCK

4.75e-053139216772601
Pubmed

Inhibition of Histone Acetylation by ANP32A Induces Memory Deficits.

ANP32A ANP32D

4.75e-053139229782322
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

NRBF2 CENPB DDX56 HEATR1 DRG1 BLM SART1 MSH6 RIF1 UTP20 CNOT1 AURKB

5.71e-057591391235915203
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

PDCD6IP CENPB CHD8 GFPT1 BLM SART1 MSH6 RIF1 EEF2 ANP32A EIF5B PSME3 ATM AURKB

5.88e-0510141391432416067
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

EPS15 CCDC66 SYNJ2 CCNB2 COASY CNOT1

6.34e-05169139631462741
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

DCAKD TBRG4 PDCD6IP CENPB DDX56 HEATR1 ACTR1A MSH6 ESYT2 EEF2 AFG3L2 ANP32A EIF5B PSME3 ATM UQCRC1 CNOT1

6.52e-0514401391730833792
Pubmed

Network organization of the human autophagy system.

WIPI1 NRBF2 PDCD6IP RUBCNL GFPT1 RIF1 ESYT2 AFG3L2 EIF5B

6.99e-05437139920562859
InteractionAGR2 interactions

DOCK2 PDCD6IP SPTA1 COQ6 CHD8 ALDH1L1 GFPT1 DNAH1 ACTR1A MSH6 NAA35 EEF2 LLGL2 EIF5B PSME3 UQCRC1 SPAG17 ATP2A1 CNOT1 HCK

5.18e-0693413720int:AGR2
Cytoband3p22.3

PDCD6IP STAC GPD1L

1.15e-043113933p22.3
GeneFamilyMaestro heat like repeat containing

MROH2A MROH1 MROH7

1.34e-0511803636
GeneFamilyATP binding cassette subfamily D

ABCD4 ABCD2

1.15e-044802808
GeneFamilyANP32 acidic nuclear phosphoproteins

ANP32A ANP32D

1.92e-04580227
GeneFamilyGlycosyl transferases group 1 domain containing

GTDC1 ALG2

8.50e-0410802427
GeneFamilyMAP kinase phosphatases

DUSP6 DUSP10

1.04e-0311802895
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

CHD7 MIDEAS CHD6

1.67e-0353803532
GeneFamilyBPI fold containing

BPIFB3 BPIFA2

2.23e-0316802456
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000

HEATR1 BLM RIF1 CCNB2 CEP70 UTP20 HERC3 ATM METTL25 M6PR FAM135A

1.09e-0533313711gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
ToppCellE17.5-Hematopoietic-Erythroid-enucleate_erythrocyte|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SPTA1 TFDP2 RSAD2 MEIOSIN PSME3 ACMSD

2.25e-078213968917c6fd4a6e3cb7a3a2af489ccc3fdc55c26698
ToppCellE17.5-Hematopoietic-Erythroid|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SPTA1 TFDP2 RSAD2 MEIOSIN PSME3 ACMSD

2.25e-07821396e0b12b9fb3cd56902b068dc0d921241481aa70a9
ToppCellLPS-antiTNF-Myeloid-Myeloid_granulocytic|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 ZMAT4 DOCK5 CEP70 FCRLB LYN HCK

3.40e-0714313974a0f26eef935fe68a1da5d319503059a8a8682dd
ToppCellLPS-antiTNF-Myeloid-Myeloid_granulocytic-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK2 ZMAT4 DOCK5 CEP70 FCRLB LYN HCK

3.40e-07143139765328a0a2f3972fac596e07933e74b2ef7cceb84
ToppCellfacs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 MYO7A ZMAT4 AMIGO1 BLM MSH6 ESYT2

9.68e-071671397961e722442d786ab15d1e490941d2be265a9057a
ToppCellfacs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT4 MYO7A ZMAT4 AMIGO1 BLM MSH6 ESYT2

9.68e-0716713973760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REXO5 BLM MSH6 CCDC66 GSTCD ATM AURKB

1.13e-0617113971eebd7138c3b20ddc1104f21615f9df0e776bbe6
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MROH2A SPTA1 LRP1B DNAH1 SLC4A4 SPAG17 UNC80

1.85e-0618413972cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MROH2A SPTA1 LRP1B DNAH1 SLC4A4 SPAG17 UNC80

1.85e-061841397ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MROH2A SPTA1 LRP1B DNAH1 SLC4A4 SPAG17 UNC80

1.85e-0618413972b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellMonocytes-Inflammatory_CD16+_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

LILRA1 DUSP6 LILRB1 DOCK5 CCDC88A LYN HCK

2.45e-0619213974be5c2c946337cd3e710137726358adca563f146
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 LILRA1 LILRB1 DOCK5 CCDC88A LYN HCK

2.81e-061961397cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUBCNL DUSP6 CHD7 STAC TFDP2 PDE8B CHD6

3.00e-061981397e442692a8a5aad5b84eabbf051d32eae01b1069a
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

DOCK2 LILRA1 LILRB1 DOCK5 CCDC88A LYN HCK

3.00e-061981397d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellcontrol-HLA-DR+_CD83+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DUSP6 LILRB1 DOCK5 RSAD2 CCDC88A LYN HCK

3.10e-061991397f1b370d2869ad29c9d8ff41fdcc486fffa781ee2
ToppCellChildren_(3_yrs)-Immune-monocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 LILRA1 LILRB1 DOCK5 CCDC88A LYN HCK

3.21e-062001397881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCellmild-CD163+_Monocytes_(Sample_ID1_d7)|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LILRA1 DUSP6 DTX3L LILRB1 RSAD2 LYN HCK

3.21e-06200139782126e25bfd8fba78dc1348fa5ad6a576289a139
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUBCNL DUSP6 PCDHA12 CHD7 STAC PDE8B

1.29e-05164139657301178e420983c0cb72178e288a3a0449fdda3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RUBCNL CCDC88A PIK3CB FCRLB LYN HCK

1.38e-05166139663dc58864268b4e7779e4c45155022556fc634f9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RUBCNL LILRB1 CCDC88A LYN HCK

1.69e-051721396f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

DOCK2 HEATR1 PLBD2 BLM MYO15B N6AMT1

1.74e-051731396efb8072475000888efe088d00e870c56ffad4172
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SPEF2 DNAH1 IQCA1 ULK4 SPAG17 ODAD3

1.80e-051741396f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SPEF2 DNAH1 IQCA1 ULK4 SPAG17 ODAD3

1.86e-051751396c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 LILRA1 RUBCNL LILRB1 LYN HCK

1.92e-051761396926ed37e636fe4dd3a18731cea15761f0c2c285a
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7A SPEF2 DNAH1 IQCA1 ULK4 SPAG17

1.98e-051771396e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 LILRA1 DUSP6 LILRB1 LYN HCK

2.25e-0518113968657d35cd3dff6c89d0fde67d7e7e81e1d6c8884
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RUBCNL CCDC88A LYN NLRP4 HCK

2.47e-0518413964f4aeef3b821a003e857fe4a195124d44b2d7479
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUBCNL DUSP6 CHD7 STAC TFDP2 CHD6

2.70e-051871396dfc2b95d70daf533bc0cc4ce78af9f65dd75a25b
ToppCellAdult|World / Lineage, Cell type, age group and donor

DOCK2 CDK5RAP3 LLGL2 MROH1 RETREG1 LYN

2.87e-0518913965cd285bfad973125d46d704fec18b21266a63379
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

DNAAF9 GTDC1 DHRS7B MSH6 HERC3 LYN

2.95e-051901396651a1d3ae286e40f9d9f60e438211c6148d24143
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUBCNL DUSP6 CHD7 STAC TFDP2 CHD6

2.95e-0519013965a82709eeb68df4563bb42b97636d110126d2f97
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RUBCNL DUSP6 NFKBIE DUSP10 LYN HCK

3.04e-05191139610644258b97f9c99eb0e199b64b970f6b986aa41
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RUBCNL DUSP6 NFKBIE DUSP10 LYN HCK

3.04e-051911396408942fc8db939239aeee6ae07a21362133c9e2e
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

DOCK2 GTDC1 STAC CCDC88A LYN HCK

3.13e-051921396733491e932350e3c216a626cc49c3cd3fe970a82
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RSAD2 CCDC66 RETREG1 ATM HERC6 ABCD2

3.22e-0519313962901d7a9672a8cf70c9f1c752685b45e4d79ac70
ToppCell10x5'-Lung-Myeloid_Monocytic|Lung / Manually curated celltypes from each tissue

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.22e-051931396ebe6be10ef5de9e1da988e263106698d3db42fce
ToppCellnormal-na-Myeloid-non-classical_monocyte-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

LILRA1 LILRB1 DOCK5 PDE8B LYN HCK

3.22e-051931396053adc7ed9f997b503e12239a684bb9f5896e10c
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Severe / Disease group, lineage and cell class

RSAD2 CCDC66 RETREG1 ATM HERC6 ABCD2

3.22e-051931396beb862d38b88572836b0a797c8efef7a2492e0b9
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RSAD2 CCDC66 RETREG1 ATM HERC6 ABCD2

3.22e-051931396f4310faa13fc8ce99a217e2d1c9cc733683797a1
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RSAD2 CCDC66 RETREG1 ATM HERC6 ABCD2

3.22e-051931396f8af695457d2a0a911a5ac491742465864ebda37
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RSAD2 CCDC66 RETREG1 ATM HERC6 ABCD2

3.22e-051931396089aece40130034a89a5213be778f10b0787eeba
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK2 WIPI1 RUBCNL LILRB1 CCDC88A LYN

3.32e-0519413963043f6230fa723037c8cf7123f611ae847b39fd4
ToppCellhealthy_donor-Myeloid-Monocytic-CD16+_Monocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.32e-051941396ecf746ef1c5c4d6d9ca06a6d3e3778670b5700c2
ToppCellnucseq-Immune-Immune_Myeloid-pMON-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DOCK2 LILRA1 LILRB1 DOCK5 LYN HCK

3.32e-051941396e237384b02be460d44eeada3026a5691c66f6fc1
ToppCellCOVID_vent-Myeloid-Monocytic-CD16+_Monocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.32e-051941396b133d3d198360269cc449a75d34c29be377d91e0
ToppCellnucseq-Immune-Immune_Myeloid-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DOCK2 LILRA1 LILRB1 DOCK5 LYN HCK

3.32e-0519413960bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCelldistal-Hematologic-Nonclassical_Monocyte-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LILRA1 LILRB1 BLM DOCK5 LYN HCK

3.32e-051941396f1cabb198ab32deaf299899c5e8f42d861b8c574
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 LILRA1 LILRB1 DOCK5 LYN HCK

3.42e-0519513961d58585557bf8e9ce4d514e128d3a902b526331d
ToppCellControl-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class

LILRA1 LILRB1 BLM DOCK5 LYN HCK

3.42e-051951396fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCellControl-Myeloid-CD16_Mono|Control / Disease, Lineage and Cell Type

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.42e-051951396a37e75be248ff28f6647e4e690629f82c1fb7370
ToppCellControl-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

LILRA1 LILRB1 BLM DOCK5 LYN HCK

3.42e-051951396b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l11|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SPTA1 TFDP2 RSAD2 PSME3 ACMSD

3.46e-051181395a58dc4fcd92adcae5fae364052be4b909797e9f0
ToppCellCOVID-19_Moderate-Non-classical_Monocyte|COVID-19_Moderate / disease group, cell group and cell class

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.52e-051961396256c557fa11414c9d2cbb1fcff33f482ee1c78ac
ToppCellCOVID-19-Myeloid-Monocytes|COVID-19 / group, cell type (main and fine annotations)

DOCK2 LILRA1 LILRB1 CCDC88A LYN HCK

3.52e-05196139604d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

DOCK2 MYO7A LILRB1 CCDC88A LYN HCK

3.52e-051961396a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.52e-05196139629246378ffb1010fe6858da756ae3d13df2306ba
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DUSP6 CHD7 STAC CCNB2 RETREG1 AURKB

3.52e-0519613964924a36a81d62863c1004b8c76f8096a1f89c548
ToppCellcontrol-Non-classical_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.52e-0519613961d71a5be652dd3281aba4f984f6ef84c993c5f63
ToppCellMultiple_Sclerosis-Myeloid-CD16_Mono|Multiple_Sclerosis / Disease, Lineage and Cell Type

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.52e-05196139683011b56780295dff5ded57064b07dcd2f19ea26
ToppCellControl-Myeloid-TRAM3|Control / Disease group,lineage and cell class （2021.01.30）

DTX3L LILRB1 RSAD2 HERC6 LYN HCK

3.62e-051971396733ff40039d67e561c2ded7c9bd0b4353101741e
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUBCNL DUSP6 CHD7 STAC TFDP2 CHD6

3.62e-0519713961378bf90a4b80b8166ef352c282ce51b114ba693
ToppCellFetal_29-31_weeks-Immune-monocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK2 LILRA1 LILRB1 CCDC88A LYN HCK

3.62e-05197139648a8169a4d33c6a68d66bcd936861c75cb4b60ef
ToppCellBronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macro_interstitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LILRA1 LILRB1 RSAD2 NFKBIE LYN HCK

3.62e-0519713961a30747a2188a890f58d831030328986b3a4356d
ToppCellBAL-Control-Myeloid-TRAM-TRAM3|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DTX3L LILRB1 RSAD2 HERC6 LYN HCK

3.62e-0519713964416efdbd9c4ac3356a5dff2d535c2d7383376a9
ToppCellFetal_29-31_weeks-Immune-monocyte-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK2 LILRA1 DUSP6 LILRB1 LYN HCK

3.62e-0519713968b9a88fb671d5c2b25d291c851e2b8a478f2610c
ToppCellBAL-Control-Myeloid-TRAM-TRAM3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DTX3L LILRB1 RSAD2 HERC6 LYN HCK

3.62e-0519713960f1c4a328968b32874e6ebb0803e665adcbbc450
ToppCellBAL-Control-Myeloid-TRAM-TRAM3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DTX3L LILRB1 RSAD2 HERC6 LYN HCK

3.62e-051971396aafe0cd697b0b7f0756596148e0906443fdf8ef7
ToppCellDendritic_cell|World / shred by cell class for turbinate

DOCK2 LILRA1 RUBCNL LILRB1 CCDC88A HCK

3.62e-051971396ab2213e3742f92798922ea318d76328b6ca18b13
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOCK2 RUBCNL DOCK5 IFRD1 ANP32A LYN

3.62e-0519713963cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCellBAL-Control-Myeloid-TRAM-TRAM3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DTX3L LILRB1 RSAD2 HERC6 LYN HCK

3.62e-051971396e131634bc67e0bd31a938a8e8df8dc752e1d0f47
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 RUBCNL LILRB1 CCDC88A LYN HCK

3.72e-05198139696883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-051981396cbbdd44dfa95370c0fbaa65ba71d86bfee0ea379
ToppCellcellseq2-Immune-Immune_Myeloid-iMON-iMON|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DOCK2 LILRA1 LILRB1 CCDC88A LYN HCK

3.72e-051981396a6aa113f0af4d25c032f440c3134fe4d88ca5055
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-0519813963bc3dbd178043deadd7eef413b2761dc003abd6e
ToppCellHealthy-Non-classical_Monocyte|Healthy / disease group, cell group and cell class

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-051981396394e5fa8998c46c6f7cd57b53f347d2029c75ae1
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-0519813969b47585653aaebd033c9b7bba93c7a7c35a4d60e
ToppCellMild-Myeloid-Macrophages-FCN1_high|Mild / Condition, Lineage, Cell class and cell subclass

LILRA1 DUSP6 LILRB1 RSAD2 LYN HCK

3.72e-05198139617aab4dc3b2cd6eb7dda77dd51bdc20490fcfe19
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DTX3L TFDP2 RSAD2 LLGL2 ATM HERC6

3.72e-051981396fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCellCOVID-19_Moderate-Non-classical_Monocyte|World / disease group, cell group and cell class

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-0519813968449934e20bb2a34079fb642cae0d4647b9efe51
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-0519813968b5d30312bbcabc6911ff03e5028766d77203dff
ToppCellHealthy-Non-classical_Monocyte|World / disease group, cell group and cell class

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-0519813964fd27a9fb3758c94ed9f0a726296e92b0625da44
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 MYO7A BLM MYO15B HCK AURKB

3.72e-051981396732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCellControl-Myeloid-Non-classical_Monocyte|Control / Disease group, lineage and cell class

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-051981396ae0a51e63e2751a6d9dc0c8a3852680949173523
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DTX3L TFDP2 RSAD2 LLGL2 ATM HERC6

3.72e-0519813961ef3a6bd681c223eed58300348adfef89df5563c
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUBCNL DUSP6 CHD7 STAC TFDP2 CHD6

3.72e-051981396c506334d81af672ef9ddc8c4fd2a790bdb58e63e
ToppCellcellseq2-Immune-Immune_Myeloid-iMON|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DOCK2 LILRA1 LILRB1 CCDC88A LYN HCK

3.72e-051981396a0ceed8689d42be6b9cde89d6c182d10b3fb14fc
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-0519813967d8fade2583c07a33dd83057cbce08e9fc77987a
ToppCellCOVID-19-kidney-Macrophages|kidney / Disease (COVID-19 only), tissue and cell type

DOCK2 LILRB1 CCDC88A DUSP10 LYN HCK

3.72e-051981396161324541fe5da5cbb58142ea94fefd39b7dfb04
ToppCell10x5'-blood-Myeloid_Monocytic|blood / Manually curated celltypes from each tissue

LILRA1 DUSP6 LILRB1 CCDC88A LYN HCK

3.72e-051981396c0985fff359c78d0fc1b6f31885aa168c9f5fdae
ToppCellPBMC-Control-Myeloid-Non-classical_Monocyte|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LILRA1 DUSP6 LILRB1 DOCK5 LYN HCK

3.72e-051981396165d60b111a17d517a420c434733eefb98da240d
ToppCellPBMC-Mild-Myeloid|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

LILRA1 DUSP6 LILRB1 CCDC88A LYN HCK

3.83e-05199139602256d86541be6851634283047fdc05fdf095114
ToppCellcontrol-CD163+_Monocytes_(Sample_ID1_d7)|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DUSP6 DTX3L LILRB1 RSAD2 LYN HCK

3.83e-051991396933201d32eda12a89660bdbae9114a95cc428a38
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LILRA1 DUSP6 LILRB1 LYN ODAD3 HCK

3.83e-05199139699eec995aa20ac22a8dd045382bd15a15db0b87a
ToppCellPBMC-Mild-Myeloid|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LILRA1 DUSP6 LILRB1 CCDC88A LYN HCK

3.83e-05199139627667838e065370d4536eaaf5b42ad322a714b96
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

LILRA1 DUSP6 LILRB1 LYN ODAD3 HCK

3.83e-051991396aca9f75c690c6ed952bcbdc7e1e7eef7719f54ca
ToppCellCOVID-19_Mild-Myeloid|COVID-19_Mild / Disease group, lineage and cell class

LILRA1 DUSP6 LILRB1 CCDC88A LYN HCK

3.83e-051991396d0c230c3699955a80630b63ed18c770444c5dfe5
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LILRA1 DUSP6 LILRB1 LYN ODAD3 HCK

3.83e-0519913963e09b3c2e2c57e5248981293020d2434e898e3e1
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LILRA1 DUSP6 LILRB1 LYN ODAD3 HCK

3.83e-051991396ae6b4b4557c6a9223acdee2a79bc780c5916d38a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK2 LILRA1 DUSP6 LILRB1 LYN HCK

3.83e-05199139687c7b8c77c28f3cfa6d6dddfd00c9d18d116207e
ToppCellPBMC-Convalescent-Myeloid-Non-classical_Monocyte|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

LILRA1 DUSP6 LILRB1 LYN ODAD3 HCK

3.83e-0519913964eed28ef8c74d7131eeeabdd732a682d91e034dd
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; HL60; HT_HG-U133A

DCAKD WIPI1 DDX49 ALDH1L1 VPS13D HERC3 ATM SLC4A4 HERC6

2.93e-0619413892430_DN
DrugRaloxifene hydrochloride [82640-04-8]; Up 200; 7.8uM; MCF7; HT_HG-U133A

SETD1A WIPI1 CEP162 DOCK5 VPS13D SYNJ2 ATM SLC4A4

2.57e-0519513886235_UP
DrugLactobionic acid [96-82-2]; Down 200; 11.2uM; PC3; HT_HG-U133A

REXO5 CEP162 STAC VPS13D PIK3CB PDE8B SLC4A4 LYN

2.67e-0519613886605_DN
DrugSuramin sodium salt; Down 200; 10uM; MCF7; HT_HG-U133A

ATN1 GTDC1 MBIP VPS13D NFKBIE GSTCD RETREG1 KIF3C

2.67e-0519613887496_DN
DrugBethanechol chloride [590-63-6]; Down 200; 20.4uM; HL60; HT_HG-U133A

DCAKD CEP162 LILRB1 DHRS7B VPS13D RETREG1 KIF3C SLC4A4

2.77e-0519713882975_DN
Drug(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; PC3; HT_HG-U133A

REXO5 GTDC1 TFDP2 VPS13D PIK3CB GSTCD RETREG1 SLC4A4

2.87e-0519813884259_DN
DrugDanazol [17230-88-5]; Up 200; 11.8uM; PC3; HG-U133A

DUSP6 CHD7 GFPT1 NAA35 VPS13D LRRC1 ATM IP6K2

2.98e-0519913881954_UP
DrugFoliosidine [2520-38-9]; Up 200; 13uM; MCF7; HT_HG-U133A

MYO7A DUSP6 CHD7 ALDH1L1 RIF1 IQCA1 PRKG2 ATP2A1

3.08e-0520013886057_UP
Drug4-chloro-2-methylphenoxyacetic acid

COQ6 BLM GSTCD

3.47e-05111383CID000007204
Drugbenoxacor

GSTCD SLC4A4

3.65e-0521382CID000062306
Drugdibenzocarbazole

SPTA1 NAP1L2

3.65e-0521382CID000155584
DrugH 297

GSTCD SLC4A4

3.65e-0521382CID000033097
Diseasecancer (implicated_via_orthology)

FLT4 TOMM20 LLGL2 PIK3CB LRRC1 AKT2 ATM COASY LYN HCK

5.38e-0726813710DOID:162 (implicated_via_orthology)
Diseasecarcinoma (implicated_via_orthology)

FLT4 LLGL2 LRRC1 DUSP10 LYN HCK

5.39e-07641376DOID:305 (implicated_via_orthology)
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD8 CHD7 CHD6

3.38e-0671373DOID:0050834 (implicated_via_orthology)
Diseaseneurodegeneration with brain iron accumulation 6 (implicated_via_orthology)

DCAKD COASY

2.14e-0521372DOID:0110740 (implicated_via_orthology)
DiseaseFamilial Progressive Myoclonic Epilepsy

ATN1 SACS AFG3L2

6.35e-05171373C0751777
DiseaseAtypical Inclusion-Body Disease

ATN1 SACS AFG3L2

6.35e-05171373C0751776
DiseaseMyoclonic Epilepsies, Progressive

ATN1 SACS AFG3L2

6.35e-05171373C0751778
DiseaseBiotin-Responsive Encephalopathy

ATN1 SACS AFG3L2

6.35e-05171373C0751780
DiseaseMay-White Syndrome

ATN1 SACS AFG3L2

6.35e-05171373C0751782
DiseaseDentatorubral-Pallidoluysian Atrophy

ATN1 SACS AFG3L2

6.35e-05171373C0751781
DiseaseBloom syndrome (implicated_via_orthology)

NSMCE2 BLM

6.40e-0531372DOID:2717 (implicated_via_orthology)
DiseaseAction Myoclonus-Renal Failure Syndrome

ATN1 SACS AFG3L2

7.59e-05181373C0751779
Diseaseectonucleoside triphosphate diphosphohydrolase 5 measurement

COQ6 MIDEAS ABCD4

1.22e-04211373EFO_0008115
DiseaseImmunologic Deficiency Syndromes

CHD7 BLM ATM

1.62e-04231373C0021051
Diseasefear of minor pain measurement

DOCK5 IQCA1 HCK

4.00e-04311373EFO_0008340
DiseaseKartagener Syndrome

SPEF2 DNAH1 ODAD3

5.75e-04351373C0022521
Diseasepulse pressure measurement, diastolic blood pressure, systolic blood pressure, hypertension

ULK4 LYN CDH18

5.75e-04351373EFO_0000537, EFO_0005763, EFO_0006335, EFO_0006336
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

SPEF2 DNAH1 ODAD3

5.75e-04351373C4551906
DiseasePolynesian Bronchiectasis

SPEF2 DNAH1 ODAD3

5.75e-04351373C4317124
Diseaseendometrial cancer (is_implicated_in)

MSH6 AKT2 ATM

6.25e-04361373DOID:1380 (is_implicated_in)
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

FLT4 LRP1B EEF2 ATM M6PR

6.52e-041481375C0279702
DiseaseCataract

CPAMD8 ATM SLC4A4

6.78e-04371373C0086543
Diseaseheart disease (implicated_via_orthology)

PIK3CB ATP2A1 CNOT1

7.33e-04381373DOID:114 (implicated_via_orthology)
DiseaseGlaucoma

CPAMD8 SLC4A4

7.54e-0491372C0017601
DiseaseAdenocarcinoma of large intestine

MSH6 AKT2 ATM PRKG2

1.06e-03961374C1319315
Diseasekidney cancer (implicated_via_orthology)

LLGL2 LRRC1

1.15e-03111372DOID:263 (implicated_via_orthology)
DiseasePrimary Ciliary Dyskinesia

SPEF2 DNAH1 ODAD3

1.37e-03471373C4551720
DiseaseMalignant neoplasm of breast

DTX3L NSMCE2 MSH6 RIF1 EEF2 LLGL2 SYNJ2 PIK3CB CHD5 MROH7 UTP20 AKT2 ATM

1.52e-03107413713C0006142
Diseasemultiple myeloma, monoclonal gammopathy

ULK4 KIF3C

1.88e-03141372EFO_0000203, EFO_0001378
Diseaseleukemia

BLM MSH6 ATM

2.15e-03551373C0023418
Diseaseleukocyte immunoglobulin-like receptor subfamily B member 1 measurement

LILRA1 LILRB1

2.16e-03151372EFO_0008208
DiseaseMyasthenic Syndromes, Congenital, Slow Channel

GFPT1 ALG2

2.46e-03161372C0751885
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

GFPT1 ALG2

2.78e-03171372C0751883
DiseaseIdiopathic hypogonadotropic hypogonadism

DUSP6 CHD7

3.12e-03181372C0342384
DiseaseCongenital Myasthenic Syndromes, Presynaptic

GFPT1 ALG2

3.47e-03191372C0751884
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

SPEF2 ODAD3

3.47e-03191372DOID:9562 (implicated_via_orthology)
Diseaseeye colour measurement

ZMAT4 PLBD2 STAC AMIGO1 DUSP10

3.57e-032181375EFO_0009764
Diseaseprostate adenocarcinoma (is_implicated_in)

PIK3CB AKT2

3.85e-03201372DOID:2526 (is_implicated_in)
Diseaseneutrophil count, basophil count

PCDHA12 CHD7 CLEC4M DRG1 LYN

4.01e-032241375EFO_0004833, EFO_0005090
Diseasecongenital heart disease (implicated_via_orthology)

CHD8 CHD7 CHD6

4.10e-03691373DOID:1682 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
EAKSLLAGLLKKDPK

AKT2

376

P31751
LSKDKGLLGKVLVAL

ESYT2

881

A0FGR8
LKIEELTLPKVLLKL

BPIFB3

91

P59826
FLEPLLEAKKAGLKL

ADAL

191

Q6DHV7
ELVKEGAKLPKLTLL

AMIGO1

176

Q86WK6
SAGKLVLIDKLLPKL

CHD8

1131

Q9HCK8
IELKALGLDSPLTEK

ANKRD34C

191

P0C6C1
LPEKEKILDKLELSL

CHD5

1641

Q8TDI0
GLKDLEEVVGLLKKL

EIF2AK4

1291

Q9P2K8
KVELPLSDTLAIKGK

ABCD2

456

Q9UBJ2
LRPLKLDSTLEKDKL

AFG3L2

491

Q9Y4W6
PLEGSKLAKKRADLV

ATN1

786

P54259
GDRLLSEVKKLAPKD

ACTR1B

311

P42025
LLLEAGPKKVLEKLS

COQ6

66

Q9Y2Z9
PLSLKLLTDVIGKDK

ACMSD

271

Q8TDX5
KDLSTIEPLKKLENL

ANP32A

101

P39687
IEPLKKLENLKSLDL

ANP32A

106

P39687
LKGLVNKPELLALTE

ARPIN

116

Q7Z6K5
KPLIKDLSLKISEGQ

ABCD4

401

O14678
KLVLIDKLLPKLKAG

CHD7

1291

Q9P2D1
LTPEREGKVKLALLL

CACNG6

31

Q9BXT2
LKLLKPDDRILIVGT

IQCA1

666

Q86XH1
LKISLPVIGLDEILK

ATP2A1

971

O14983
LDLLLGSLKEKPVTK

MROH7

816

Q68CQ1
LKLLTDIKVKLSDPG

NAP1L2

266

Q9ULW6
EDLVRIKKGLLAPLL

RUBCNL

566

Q9H714
IKKGLLAPLLKDILK

RUBCNL

571

Q9H714
LKREILPKALKDKGI

UROS

146

P10746
LGSVDERKELLPKKI

LRP1B

4576

Q9NZR2
LIVLDVLKPLGHKKI

DRG1

146

Q9Y295
LEGPLSRVKSLKKSL

LLGL2

636

Q6P1M3
RELLGPVLKKLTELK

IP6K2

301

Q9UHH9
VPKKALGITLIKGID

GPD1L

111

Q8N335
KLLNVKPGLEDLKEL

HERC3

816

Q15034
LVLLPFDDLKISGKL

NFKBIE

481

O00221
KKLGLDESKLPEKII

METTL25

516

Q8N6Q8
KAIPLALEGKDLLAR

DDX56

36

Q9NY93
LESLKREGKEPLVLK

DUSP10

256

Q9Y6W6
QGTEEVKKLLLLLLG

CCDC88A

116

Q3V6T2
LLSKEPGKRLELKEN

KIF3C

156

O14782
FLQAKEELKLLKLPG

FAM135A

1206

Q9P2D6
LKDLDPIGKATLVKS

PDCD6IP

326

Q8WUM4
KGELLGKELADLPKS

PDE8B

306

O95263
ISKPDRKKLAAKLGL

DBX1

206

A6NMT0
KLLDQKPSLEDLKEL

HERC6

786

Q8IVU3
KIPDLKLLVEKKFLA

NSMCE2

96

Q96MF7
DADIPALLGTKILLK

NLRP4

426

Q96MN2
VLGIKVETKDPALKL

MROH1

776

Q8NDA8
LLKKLPDLERLLSKI

MSH6

811

P52701
ALLLPIALKTGTKKL

MEIOSIN

86

C9JSJ3
LSKDLPKAVELLGDI

UQCRC1

136

P31930
LLKNLPEDKLTKIID

PRKG2

286

Q13237
AEKARLLKGPIEKEL

NRBF2

201

Q96F24
LSLPDISLEALQKKK

IRGC

246

Q6NXR0
ETIPDGIGKLKKLSI

LRRC1

256

Q9BTT6
LRKIDPKDEALAKLG

MYO15B

1116

Q96JP2
EGLKKIPSEKLSRIV

DNAH1

2086

Q9P2D7
KGDSSRLLKALPLKL

ATM

1101

Q13315
SISDLPKLKLRKLEL

ANP32C

56

O43423
AGLPVKGIILKEKAL

CENPB

91

P07199
EIPRESLKLEKKLGA

HCK

256

P08631
LKGILEKLKVDLGVL

BPIFA2

51

Q96DR5
KLIDTIPDDKLKLLD

BLM

381

P54132
LLSGTLPKDELKELK

DOCK2

131

Q92608
ILSGTLPKDELAELK

DOCK5

131

Q9H7D0
TLILKELKFELGRPL

CCNB2

251

O95067
LKPLSLVKRTDLKDL

CEP70

41

Q8NHQ1
KLLIKEKGGELTLLG

DTX3L

331

Q8TDB6
AAGKLVLIDKLLPKL

CHD6

781

Q8TD26
ILDIPLLFETKKLLK

DCAKD

111

Q8WVC6
AALEPKLDLLLEKTK

CDK5RAP3

466

Q96JB5
LDKGTIKLKVPTGLR

CPAMD8

81

Q8IZJ3
GLKLETELLDGKTKL

CCDC66

6

A2RUB6
GDSKLPKKTEQIRLL

DNAAF9

356

Q5TEA3
GDRLLSEVKKLAPKD

ACTR1A

311

P61163
ILSGTKLIKPAALDK

CEP162

556

Q5TB80
ESEEILKTLGPILKK

IFRD1

161

O00458
LKSDEGGKVLLPKLI

LYN

331

P07948
DILETLNKLLLKKPL

MIDEAS

801

Q6PJG2
KKLEDKILELEGISP

MBIP

276

Q9NS73
DKETREGILSLKKPL

CDH18

321

Q13634
LILEGKDPDLEAKRK

DDX49

416

Q9Y6V7
IIKTLTKIPSLIKDG

HEATR1

286

Q9H583
DLPKLVEGLKRLAKS

EEF2

516

P13639
LSGDKVKPVLLNSKL

EPS15

146

P42566
GKKKKDVILADLLPS

DHRS7B

281

Q6IAN0
GLLLTEKPIVLKAES

CYP3A7

481

P24462
LKGLLSRVVLELKEP

FCRLB

381

Q6BAA4
TELAALRPDLGKLKK

GTDC1

71

Q4AE62
GESVLGLLLKKLKDE

DUSP6

111

Q16828
LAVKEFLGLLKKPTV

SACS

2276

Q9NZJ4
PLKKELLELLGFKKT

GSTCD

121

Q8NEC7
IKKATRPEELLELLG

TBRG4

76

Q969Z0
KDKSILPELVLRKLL

PCDHA12

186

Q9UN75
EKLLKPAALLLEKGA

MROH2A

1381

A6NES4
GLLKAILSRKLLVPE

UTP20

2226

O75691
EQLLKKGKSIPDVLL

SPEF2

691

Q9C093
PLEEAKRGLLLLKEA

RSAD2

101

Q8WXG1
AKGGKLEKLETLLRP

SYNJ2

341

O15056
LGLKRLPDLIKEVLS

GFPT1

526

Q06210
PSDLLELLVLGVSKK

LILRA1

211

O75019
PSDLLELLVLGVSKK

LILRB1

211

Q8NHL6
SLGLPTELKRKKEQL

RETREG1

366

Q9H6L5
PLGKLTSLFKLIVKV

RIF1

796

Q5UIP0
KKDLTKALRLLTPGD

IQCA1L

651

A6NCM1
VPNLLGLVEEKLLKL

ODAD3

496

A5D8V7
DLKVLGPKDSKITRL

OVCH1

956

Q7RTY7
KDLEKTLAGLPLLVA

EIF5B

936

O60841
GKKFLPVLKEILDRD

PIK3CB

531

P42338
LKLELKAKGSALDPA

PPP1R15B

156

Q5SWA1
EKTKLKEPGLLSLVD

SETD1A

851

O15047
LEDLKLAKSLVPKAL

TFDP2

331

Q14188
SGEKLTLPLIGKLLK

SPAG17

116

Q6Q759
LDDLVPKGKKFLLLS

ALG2

216

Q9H553
ALKFAELTLKAGIPK

ALDH1L1

606

O75891
KDLSTIEPLKKLENL

ANP32D

101

O95626
LGGVPIIAKLIKTKD

ARMCX1

246

Q9P291
RLKAAVGELPEKSKL

CLEC4M

141

Q9H2X3
VADKDLLKSKLLPEL

COASY

226

Q13057
VLKSLPDKLKAEIAI

CNGA3

456

Q16281
ELKPGNLLKDKDRLK

CNOT1

1296

A5YKK6
IKPENLLLGLKGELK

AURKB

201

Q96GD4
KKLLELDSFLKEPIL

PSME3

36

P61289
DILELVKAEKPLKSL

UNC80

2316

Q8N2C7
ESEKELALVKRLKPL

M6PR

41

P20645
KDGTIKIKDLTLPEL

NAA35

91

Q5VZE5
LFLGLEAVILPKDLK

REXO5

621

Q96IC2
LSGKKKGLIPLDVLE

STAC

386

Q99469
PRKSLELLVGEKLVL

FLT4

236

P35916
EALKEPLATRKKKLL

SPTA1

776

P02549
EETNKLRAKLGLKPL

SART1

121

O43290
ELIKLAEKLKLSDPL

SEC16B

671

Q96JE7
KDLKDKRLVSIPELL

USP24

351

Q9UPU5
IETGLLKPELKDKVT

SLC4A4

191

Q9Y6R1
LELALNKTKIKPSLG

PLBD2

226

Q8NHP8
IKDMKLLKTLLDIPA

WIPI1

126

Q5MNZ9
KRLKLLLGEKTPLKT

ZMAT4

101

Q9H898
KLAKERAGLSKLPDL

TOMM20

46

Q15388
LLTSKEDPKEQKLLL

ULK4

1206

Q96C45
ELENLPLKKDALKEL

VPS13D

36

Q5THJ4
ALLKLGKLPLLYKLS

NAALADL2

301

Q58DX5
KGLLPRLTEKVDLLV

N6AMT1

106

Q9Y5N5
PLKQALLKKLLGSEE

MYO7A

1751

Q13402