Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 DDI2 ERVK-7 DDI1 ERVK-8 ERVK-19 ERVK-25

6.50e-09371417GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 DDI2 ERVK-7 DDI1 ERVK-8 ERVK-19 ERVK-25

7.92e-09381417GO:0070001
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 TERF2 ERVK-8 ERVK-11

3.11e-08141415GO:0003964
GeneOntologyMolecularFunctiontransition metal ion binding

TBXAS1 ERVK-6 ZSWIM8 CYP2C18 CYP2J2 MYO9B CBLC MMP21 TRIM43 TRIM77 ERVK-7 BMP1 PHYH ZNF22 MGAT5 AEBP1 ERVK-8 ALKBH3 HAAO ERVK-19 USP39 MMP9 MMP13 ERVK-11 MPPE1 PCK1 PCK2

6.01e-08118914127GO:0046914
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 PIDD1 MMP21 CASP10 DDI2 ERVK-7 XPNPEP2 DDI1 PRPF8 BMP1 USP2 AEBP1 ERVK-8 ERVK-19 ERVK-25 USP39 MMP9 MMP13 ESPL1

1.80e-0765414119GO:0008233
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-6 SMARCA5 RTEL1 CHD9 ERVK-7 TERF2 CRY1 CHD5 ERVK-8 ALKBH3 ERVK-11 TOP2A

3.60e-0726214112GO:0140097
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 PIDD1 MMP21 CASP10 DDI2 ERVK-7 DDI1 BMP1 USP2 ERVK-8 ERVK-19 ERVK-25 MMP9 MMP13 ESPL1

4.02e-0743014115GO:0004175
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-8 ERVK-11

7.57e-07111414GO:0004523
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 TERF2 ERVK-8 ERVK-11

6.80e-06381415GO:0034061
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-8 ERVK-11

1.30e-05211414GO:0035613
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-6 SMARCA5 RTEL1 IARS1 NARS1 CHD9 ERVK-7 TERF2 WARS2 CRY1 CHD5 ERVK-8 ALKBH3 ERVK-11 SNRNP200 TOP2A

1.33e-0564514116GO:0140640
GeneOntologyMolecularFunctionphosphoenolpyruvate carboxykinase activity

PCK1 PCK2

4.95e-0521412GO:0004611
GeneOntologyMolecularFunctionphosphoenolpyruvate carboxykinase (GTP) activity

PCK1 PCK2

4.95e-0521412GO:0004613
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-8 ERVK-11

1.31e-04371414GO:0016891
GeneOntologyMolecularFunctionzinc ion binding

ERVK-6 ZSWIM8 MYO9B CBLC MMP21 TRIM43 TRIM77 ERVK-7 BMP1 ZNF22 AEBP1 ERVK-8 ERVK-19 USP39 MMP9 MMP13 ERVK-11

1.86e-0489114117GO:0008270
GeneOntologyMolecularFunctionlinoleic acid epoxygenase activity

CYP2C18 CYP2J2

2.94e-0441412GO:0071614
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-8 ERVK-11

3.09e-04461414GO:0016893
GeneOntologyMolecularFunctionsomatostatin receptor activity

SSTR1 SSTR4

4.88e-0451412GO:0004994
GeneOntologyMolecularFunctionmetallopeptidase activity

MMP21 XPNPEP2 PRPF8 BMP1 AEBP1 MMP9 MMP13

5.55e-042001417GO:0008237
GeneOntologyMolecularFunctiondioxygenase activity

KDM3B JMJD1C PHYH ALKBH3 HAAO

6.56e-04981415GO:0051213
GeneOntologyMolecularFunctioncarbon-carbon lyase activity

BCKDHA CRY1 PCK1 PCK2

6.58e-04561414GO:0016830
GeneOntologyMolecularFunctioniron ion binding

TBXAS1 CYP2C18 CYP2J2 PHYH ALKBH3 HAAO

1.17e-031661416GO:0005506
GeneOntologyMolecularFunctionferrous iron binding

PHYH ALKBH3 HAAO

1.22e-03301413GO:0008198
GeneOntologyMolecularFunctionmanganese ion binding

MGAT5 MPPE1 PCK1 PCK2

1.60e-03711414GO:0030145
GeneOntologyMolecularFunctionheme transmembrane transporter activity

ABCB7 ABCB6

1.73e-0391412GO:0015232
GeneOntologyMolecularFunctionprotein-glutamine gamma-glutamyltransferase activity

TGM6 F13A1

1.73e-0391412GO:0003810
GeneOntologyMolecularFunctioncarboxy-lyase activity

BCKDHA PCK1 PCK2

2.07e-03361413GO:0016831
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

SMARCA5 RTEL1 CHD9 CHD5 TOP2A

2.09e-031271415GO:0008094
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

SMARCA5 CHD9 CHD5

2.25e-03371413GO:0140658
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 ERVK-8 ERVK-11

2.38e-03791414GO:0004521
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

TBXAS1 CYP2C18 CYP2J2 KDM3B PHYH ALKBH3

2.58e-031941416GO:0016705
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERVK-7 ERVK-8 ALKBH3 ERVK-11

2.81e-031361415GO:0004519
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-6 IARS1 NARS1 ERVK-7 WARS2 ERVK-8 ALKBH3 ERVK-11 SNRNP200

2.88e-034171419GO:0140098
GeneOntologyMolecularFunctionligase activity, forming carbon-oxygen bonds

IARS1 NARS1 WARS2

3.23e-03421413GO:0016875
GeneOntologyMolecularFunctionaminoacyl-tRNA ligase activity

IARS1 NARS1 WARS2

3.23e-03421413GO:0004812
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-8 ERVK-11

1.35e-06131394GO:0015074
GeneOntologyBiologicalProcessshort-chain fatty acid catabolic process

PHYH PCK1 PCK2

1.64e-0581393GO:0019626
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-6 ERVK-7 SYCP1 ERVK-8 ERVK-11

1.75e-05481395GO:0000731
GeneOntologyBiologicalProcesspropionate catabolic process

PCK1 PCK2

4.51e-0521392GO:0019543
GeneOntologyBiologicalProcessglycerol biosynthetic process from pyruvate

PCK1 PCK2

4.51e-0521392GO:0046327
MousePhenoherniated abdominal wall

ALX4 BMP1 AEBP1 SCRIB

1.28e-05201044MP:0000757
DomainPEP_carboxykin_GTP_CS

PCK1 PCK2

5.26e-0521362IPR018091
DomainPEPCK

PCK1 PCK2

5.26e-0521362PF00821
DomainPEP_carboxykinase_GTP

PCK1 PCK2

5.26e-0521362IPR008209
DomainDDI1_N

DDI2 DDI1

5.26e-0521362IPR033882
DomainPEPCK_GTP

PCK1 PCK2

5.26e-0521362PS00505
DomainPEP_carboxykinase_N

PCK1 PCK2

5.26e-0521362IPR008210
DomainPEP_carboxykinase_C

PCK1 PCK2

5.26e-0521362IPR013035
Domain-

PCK1 PCK2

5.26e-05213623.90.228.20
Domain-

PCK1 PCK2

5.26e-05213623.40.449.10
DomainPeptidase_Metallo

MMP21 BMP1 MMP9 MMP13

5.55e-05291364IPR006026
DomainZnMc

MMP21 BMP1 MMP9 MMP13

5.55e-05291364SM00235
DomainSox_N

SOX9 SOX10

1.57e-0431362IPR022151
DomainSox_N

SOX9 SOX10

1.57e-0431362PF12444
DomainGPCR_chapero_1

ANKRD13D ANKRD13A

3.13e-0441362PF11904
DomainCoact_PPARg

FAM120A FAM120C

3.13e-0441362IPR026784
DomainANKRD13

ANKRD13D ANKRD13A

3.13e-0441362IPR021832
DomainPG_binding_1

MMP21 MMP9 MMP13

3.93e-04201363PF01471
DomainPeptidoglycan-bd-like

MMP21 MMP9 MMP13

3.93e-04201363IPR002477
DomainKIND_dom

FRMPD2 SPIRE1

5.19e-0451362IPR011019
DomainSomatstn_rcpt

SSTR1 SSTR4

5.19e-0451362IPR000586
DomainAsp_protease

DDI2 DDI1

5.19e-0451362PF09668
DomainKIND

FRMPD2 SPIRE1

5.19e-0451362SM00750
DomainPeptidase_aspartic_DDI1-type

DDI2 DDI1

5.19e-0451362IPR019103
DomainKIND

FRMPD2 SPIRE1

5.19e-0451362PS51377
DomainHemopexin-like_dom

MMP21 MMP9 MMP13

6.01e-04231363IPR000585
DomainHemopexin-like_repeat

MMP21 MMP9 MMP13

6.01e-04231363IPR018487
DomainHEMOPEXIN

MMP21 MMP9 MMP13

6.01e-04231363PS00024
Domain-

MMP21 MMP9 MMP13

6.01e-042313632.110.10.10
DomainHEMOPEXIN_2

MMP21 MMP9 MMP13

6.01e-04231363PS51642
DomainHX

MMP21 MMP9 MMP13

6.01e-04231363SM00120
DomainM10A_MMP

MMP21 MMP9 MMP13

6.01e-04231363IPR033739
DomainHemopexin

MMP21 MMP9 MMP13

6.01e-04231363PF00045
DomainPept_M10A

MMP21 MMP9 MMP13

6.01e-04231363IPR021190
DomainPeptidase_M10

MMP21 MMP9 MMP13

6.83e-04241363PF00413
Domain-

SOX9 SOX10 SRY CHD5

6.88e-045513641.10.30.10
DomainIg_E-set

PDE6D TGM6 F13A1 PLXNC1 SNRNP200

9.82e-041041365IPR014756
DomainHMG_box_dom

SOX9 SOX10 SRY CHD5

1.29e-03651364IPR009071
DomainSNF2_N

SMARCA5 CHD9 CHD5

1.60e-03321363IPR000330
DomainSNF2_N

SMARCA5 CHD9 CHD5

1.60e-03321363PF00176
DomainTransglut_N

TGM6 F13A1

1.83e-0391362PF00868
DomainTRANSGLUTAMINASES

TGM6 F13A1

1.83e-0391362PS00547
DomainPAX

PAX8 PAX3

1.83e-0391362SM00351
Domain-

TGM6 F13A1

1.83e-03913623.90.260.10
DomainPAIRED_2

PAX8 PAX3

1.83e-0391362PS51057
DomainGln_gamma-glutamylTfrase_euk

TGM6 F13A1

1.83e-0391362IPR023608
DomainTransglutaminase_AS

TGM6 F13A1

1.83e-0391362IPR013808
DomainPAIRED_1

PAX8 PAX3

1.83e-0391362PS00034
DomainTransglutaminase_N

TGM6 F13A1

1.83e-0391362IPR001102
DomainTransglut_C

TGM6 F13A1

1.83e-0391362PF00927
DomainPaired_dom

PAX8 PAX3

1.83e-0391362IPR001523
DomainPAX

PAX8 PAX3

1.83e-0391362PF00292
DomainDNA/RNA_helicase_DEAH_CS

SMARCA5 RTEL1 CHD5

2.08e-03351363IPR002464
DomainTransglutaminase_C

TGM6 F13A1

2.28e-03101362IPR008958
DomainDEAH_ATP_HELICASE

SMARCA5 RTEL1 CHD5

2.64e-03381363PS00690
DomainTransglutaminase-like

TGM6 F13A1

2.77e-03111362IPR002931
DomainTGc

TGM6 F13A1

2.77e-03111362SM00460
DomainTransglut_core

TGM6 F13A1

2.77e-03111362PF01841
Domain-

MMP21 BMP1 MMP9 MMP13

2.90e-038113643.40.390.10
DomainMetalloPept_cat_dom

MMP21 BMP1 MMP9 MMP13

2.90e-03811364IPR024079
DomainCYSTEINE_SWITCH

MMP21 MMP9 MMP13

3.29e-03411363PS00546
Domain-

DDI2 DDI1

3.31e-031213622.40.70.10
DomainDUF4599

SPATA31D4 SPATA31D3

3.31e-03121362PF15371
DomainDUF4599

SPATA31D4 SPATA31D3

3.31e-03121362IPR027970
DomainRossmann-like_a/b/a_fold

IARS1 WARS2 CRY1

3.77e-03431363IPR014729
Domain-

IARS1 WARS2 CRY1

3.77e-034313633.40.50.620
DomainPept_M10_metallopeptidase

MMP21 MMP9 MMP13

3.77e-03431363IPR001818
Domain-

SEL1L MMP9

3.90e-031313622.10.10.10
DomainCyt_P450_E_grp-I

TBXAS1 CYP2C18 CYP2J2

4.29e-03451363IPR002401
DomainFN_type2_col-bd

SEL1L MMP9

4.52e-03141362IPR000562
DomainFN2_2

SEL1L MMP9

4.52e-03141362PS51092
DomainFN2_1

SEL1L MMP9

4.52e-03141362PS00023
DomainPIN_domain-like

FAM120A FAM120C

4.52e-03141362IPR029060
Domainfn2

SEL1L MMP9

4.52e-03141362PF00040
DomainFN2

SEL1L MMP9

4.52e-03141362SM00059
DomainPept_M10A_Zn_BS

MMP9 MMP13

5.19e-03151362IPR021158
DomainZINC_PROTEASE

MMP21 BMP1 MMP9 MMP13

5.73e-03981364PS00142
DomainGal_mutarotase_SF_dom

MAN2B2 GANAB

6.66e-03171362IPR011013
DomainHemopexin_CS

MMP9 MMP13

6.66e-03171362IPR018486
DomainPeptidase_aspartic_dom

DDI2 DDI1

6.66e-03171362IPR021109
DomainHMG_box

SOX9 SOX10 SRY

6.78e-03531363PF00505
DomainCyt_P450_CS

TBXAS1 CYP2C18 CYP2J2

6.78e-03531363IPR017972
DomainHMG_BOX_2

SOX9 SOX10 SRY

7.14e-03541363PS50118
DomainHMG

SOX9 SOX10 SRY

7.14e-03541363SM00398
Pubmed

Defects in chondrocyte maturation and secondary ossification in mouse knee joint epiphyses due to Snorc deficiency.

SOX9 MMP9 MMP13 TOP2A

9.09e-0811144428323137
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

SMARCA5 LAMA1 PRPF8 SERPINA12 FAM120C SNX25 SYCP1 SNRNP200 TOP2A

6.27e-07234144936243803
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-19

6.91e-075144312629516
Pubmed

SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease.

SOX10 SRY PAX3

6.91e-075144325267720
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SMARCA5 CYP2C18 ACACA KDM3B CBLC TERF2 PPL ESF1 YEATS2 MYOF SCRIB ESPL1 KLHDC4 SNRNP200 TOP2A

8.52e-077741441515302935
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZSWIM8 SMARCA5 PNMA1 DSC2 MMP21 CHD9 BCKDHA INTS10 YEATS2 FAM120A SLC35F3 FAM120C CHD5 SCRIB TOP2A PTCD3 DCAF7 BRWD1

9.20e-0711161441831753913
Pubmed

Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells.

SOX9 SOX10 ALX4 PAX3

1.95e-0622144415162501
Pubmed

Single-Cell Multiomic Approaches Reveal Diverse Labeling of the Nervous System by Common Cre-Drivers.

SOX9 SOX10 PAX3

2.40e-067144333935652
Pubmed

Choline kinase beta is required for normal endochondral bone formation.

SOX9 MMP9 MMP13

2.40e-067144324637075
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-8 ERVK-19 ERVK-25 ERVK-11

2.74e-0694144621542922
Pubmed

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.

SOX10 SRY ALX4 PAX3

2.81e-0624144416582099
Pubmed

Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo.

LAMA1 MMP9 MMP13

3.83e-068144323091646
Pubmed

Pax7 lineage contributions to the mammalian neural crest.

SOX9 SOX10 PAX3

3.83e-068144322848431
Pubmed

Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.

SOX9 SOX10 LAMA1

3.83e-068144324198279
Pubmed

Keratinocyte Growth Factor Stimulates Growth of p75+ Neural Crest Lineage Cells During Middle Ear Cholesteatoma Formation in Mice.

SOX9 SOX10 PAX3

3.83e-068144336210210
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

SMARCA5 RRP1B IARS1 SPTBN2 NARS1 PRPF8 PPL ESF1 MYOF FAM120A CHD5 USP39 SCRIB GNAS SNRNP200 TOP2A PTCD3 DCAF7

4.86e-0612571441836526897
Pubmed

Detection of gelatinolytic activity in developing basement membranes of the mouse embryo head by combining sensitive in situ zymography with immunolabeling.

LAMA1 MMP9 MMP13

5.73e-069144322688677
Pubmed

Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos.

SOX10 PAX3 KLHDC4 PCK2

7.10e-0630144431789450
Pubmed

Lack of in vivo functional compensation between Pax family groups II and III in rodents.

SOX10 PAX8 PAX3

8.17e-0610144321512107
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SEL1L ABCB7 RRP1B SPTBN2 LEMD2 NARS1 BCKDHA PRPF8 ANKRD13A MYOF GANAB FAM120A USP39 SCRIB GNAS SNRNP200 TOP2A PCK2 PTCD3

8.33e-0614401441930833792
Pubmed

LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.

SEL1L SMARCA5 IARS1 NARS1 PRPF8 PPL GANAB SNRNP200 TOP2A

9.63e-06327144931409639
Pubmed

Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice.

SOX9 MMP9 MMP13

1.12e-0511144324248941
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

SMARCA5 ACACA PRPF8 FAM120A MYH15 SNRNP200 DCAF7

1.15e-05182144732239614
Pubmed

Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.

SOX9 SOX10 ALX4 PAX3

1.19e-0534144412086465
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

SMARCA5 DSC2 RRP1B MYO9B CHD9 HSPBP1 TERF2 GANAB USP39 SNRNP200 TOP2A

1.48e-055331441130554943
Pubmed

A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network.

SOX9 SOX10 PAX3

1.49e-0512144326952979
Pubmed

Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis.

SOX9 SRY SYCP1

1.49e-0512144336414375
Pubmed

Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.

SOX9 SOX10 SRY

1.49e-0512144311071752
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-8 ERVK-19

1.49e-0512144314557543
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

ACACA IARS1 DDI2 BCKDHA GANAB FAM120A PRIM2 USP39 SCRIB GNAS PTCD3

1.50e-055341441135032548
Pubmed

Association of MMP9-1562C/T and MMP13-77A/G Polymorphisms with Non-Small Cell Lung Cancer in Southern Chinese Population.

MMP9 MMP13

1.70e-052144230889876
Pubmed

Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia.

LAMA1 MMP9

1.70e-052144219200854
Pubmed

A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke.

MMP9 MMP13

1.70e-052144215947272
Pubmed

AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer.

SOX9 SOX10

1.70e-052144233985544
Pubmed

USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals.

CRY1 USP2

1.70e-052144222669941
Pubmed

Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis.

PCK1 PCK2

1.70e-052144238697449
Pubmed

Effect of age on vascularization during fracture repair.

MMP9 MMP13

1.70e-052144218464248
Pubmed

Association of a polymorphism in the gene encoding phosphoenolpyruvate carboxykinase 1 with high-density lipoprotein and triglyceride levels.

PCK1 PCK2

1.70e-052144216132948
Pubmed

[SRY and SOX9: the main genetic factors of mammalian sex determination].

SOX9 SRY

1.70e-052144222827036
Pubmed

Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma.

SOX9 SOX10

1.70e-052144225629959
Pubmed

Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome.

SOX10 PAX3

1.70e-052144210942418
Pubmed

Expression of SOX9 and SOX10 in central neuroepithelial tumor.

SOX9 SOX10

1.70e-052144216791471
Pubmed

Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer.

SOX10 PAX3

1.70e-052144212668617
Pubmed

Variability in clinical phenotypes of PRPF8-linked autosomal dominant retinitis pigmentosa correlates with differential PRPF8/SNRNP200 interactions.

PRPF8 SNRNP200

1.70e-052144229087248
Pubmed

The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation.

SOX9 SRY

1.70e-052144225088423
Pubmed

Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-induced albuminuria and glomerulosclerosis.

MMP9 MMP13

1.70e-052144220407279
Pubmed

Sry and Sox9: mammalian testis-determining genes.

SOX9 SRY

1.70e-052144210412367
Pubmed

Genetic variations in MMP9 and MMP13 contribute to tooth agenesis in a Brazilian population.

MMP9 MMP13

1.70e-052144224351915
Pubmed

Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites.

GNAS PCK1

1.70e-052144210221772
Pubmed

MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing.

MMP9 MMP13

1.70e-052144219590036
Pubmed

Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia.

MMP9 MMP13

1.70e-052144219615667
Pubmed

The molecular action of testis-determining factors SRY and SOX9.

SOX9 SRY

1.70e-052144211990798
Pubmed

Confirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach.

MMP9 MMP13

1.70e-052144216331612
Pubmed

Mutations in SRY and SOX9: testis-determining genes.

SOX9 SRY

1.70e-05214429143916
Pubmed

Co-expression of SOX9 and SOX10 during melanocytic differentiation in vitro.

SOX9 SOX10

1.70e-052144215896776
Pubmed

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis.

PCK1 PCK2

1.70e-052144234020084
Pubmed

Sry: the master switch in mammalian sex determination.

SOX9 SRY

1.70e-052144221062860
Pubmed

Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice.

SOX9 SRY

1.70e-052144215680367
Pubmed

Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal.

SOX9 SRY

1.70e-052144215680364
Pubmed

Active matrix metalloproteases are expressed early on and are high during the Barrett's esophagus malignancy sequence.

MMP9 MMP13

1.70e-052144225562781
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

1.70e-05214429060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

1.70e-05214429460924
Pubmed

PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis.

PCK1 PCK2

1.70e-052144223466304
Pubmed

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe.

RTEL1 TERF2

1.70e-052144229290468
Pubmed

PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells.

PAX8 PCK1

1.70e-052144237102687
Pubmed

PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects.

PRPF8 SNRNP200

1.70e-052144238605034
Pubmed

Extended pedigree with multiple cases of XX sex reversal in the absence of SRY and of a mutation at the SOX9 locus.

SOX9 SRY

1.70e-052144218391513
Pubmed

Identification of two novel mutations in Shh long-range regulator associated with familial pre-axial polydactyly.

SOX9 PAX3

1.70e-052144220569257
Pubmed

Complementation of melanocyte development in SOX10 mutant neural crest using lineage-directed gene transfer.

SOX10 PAX3

1.70e-052144214699577
Pubmed

Quantitative imaging mass spectrometry of renal sulfatides: validation by classical mass spectrometric methods.

GAL3ST1 PAX8

1.70e-052144225274613
Pubmed

Epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4: implication in tissue fibrosis.

MMP9 MMP13

1.70e-052144220847282
Pubmed

The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit.

PRPF8 SNRNP200

1.70e-052144231914407
Pubmed

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.

PRPF8 SNRNP200

1.70e-052144223704370
Pubmed

Quantitative real-time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA expression in breast cancer.

MMP9 ADGRL3

1.70e-052144223317273
Pubmed

SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors.

SOX9 SRY

1.70e-052144215385158
Pubmed

Functional analysis of Waardenburg syndrome-associated PAX3 and SOX10 mutations: report of a dominant-negative SOX10 mutation in Waardenburg syndrome type II.

SOX10 PAX3

1.70e-052144221965087
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

SMARCA5 PNMA1 RRP1B MYO9B BCKDHA PRPF8 TERF2 ESF1 FAM120A ESPL1 SNRNP200 TOP2A DCAF7

1.76e-057591441335915203
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ZSWIM8 SMARCA5 ACACA RRP1B SPTBN2 NARS1 PRPF8 ESF1 GANAB FAM120A SNRNP200 PTCD3

1.89e-056531441222586326
Pubmed

HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia.

SOX9 SOX10 PAX3

1.93e-0513144324760871
Pubmed

Post-transcriptional regulation in cranial neural crest cells expands developmental potential.

SOX9 SOX10 PAX3

1.93e-0513144336724256
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SMARCA5 ACACA SPTBN2 KDM3B JMJD1C ESF1 YEATS2 SCRIB SNRNP200 TOP2A DCAF7

1.94e-055491441138280479
Pubmed

Pigmentation-related genes and their implication in malignant melanoma susceptibility.

SOX10 OCA2 PAX3

2.45e-0514144319320733
Pubmed

Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions.

PRPF8 USP39 SNRNP200

2.45e-0514144311971955
Pubmed

Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia.

SOX10 NGF PAX3

2.45e-0514144335713404
Pubmed

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification.

SOX9 MMP9 MMP13

2.45e-0514144320179096
Pubmed

The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival.

SOX9 SOX10 PAX3

2.45e-0514144335839257
Pubmed

The dual origin of the peripheral olfactory system: placode and neural crest.

SOX9 SOX10 PAX3

2.45e-0514144321943152
Pubmed

Osteoclasts and Macrophages-Their Role in Bone Marrow Cavity Formation During Mouse Embryonic Development.

SOX9 MMP9 MMP13

3.05e-0515144335689447
Pubmed

Differential isoform expression and alternative splicing in sex determination in mice.

SOX9 SOX10 SRY

3.05e-0515144330871468
Pubmed

Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.

SOX9 SOX10 PAX3

3.05e-0515144325794678
Pubmed

Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9.

SOX9 MMP9 MMP13

3.05e-0515144325564625
Pubmed

New semidominant mutations that affect mouse development.

SOX9 SOX10 PAX3

3.74e-0516144315384171
Pubmed

Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling.

SOX9 GNAS MMP13

3.74e-0516144330111653
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

ACACA CYP2J2 RTEL1 ATP9B BMP1 ESPL1

4.28e-05152144634299191
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

RTEL1 KDM3B MYOF CHD5 SCRIB BAIAP3 SNRNP200

4.48e-05225144712168954
Pubmed

Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome.

DDI2 DDI1

5.09e-053144229788202
Pubmed

Mutation Analysis of Pre-mRNA Splicing Genes PRPF31, PRPF8, and SNRNP200 in Chinese Families with Autosomal Dominant Retinitis Pigmentosa.

PRPF8 SNRNP200

5.09e-053144230360737
Pubmed

Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells.

MMP9 MMP13

5.09e-053144238471488
Pubmed

Characteristics of testicular dysgenesis syndrome and decreased expression of SRY and SOX9 in Frasier syndrome.

SOX9 SRY

5.09e-053144218271004
Pubmed

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.

MMP9 MMP13

5.09e-053144215539485
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP21 MMP9 MMP13

2.71e-0424963891
GeneFamilySomatostatin receptors

SSTR1 SSTR4

2.76e-045962257
GeneFamilyTransglutaminases

TGM6 F13A1

9.80e-049962773
GeneFamilyPaired boxes

PAX8 PAX3

9.80e-049962675
GeneFamilyATP binding cassette subfamily B

ABCB7 ABCB6

1.49e-0311962806
GeneFamilyWD repeat domain containing|DDB1 and CUL4 associated factors

DCAF7 BRWD1

4.04e-0318962498
GeneFamilyAminoacyl tRNA synthetases, Class I

IARS1 WARS2

4.50e-0319962131
GeneFamilySRY-boxes

SOX9 SOX10

4.50e-0319962757
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)|Thalamus / BrainAtlas - Mouse McCarroll V32

CASS4 IGF2-AS LAMA1 ALX4 OSGIN1

1.00e-05921385bbaf5a131f860198840e34843b7c841bcc98d9c4
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-|Thalamus / BrainAtlas - Mouse McCarroll V32

CASS4 IGF2-AS LAMA1 ALX4 OSGIN1

1.00e-05921385e6aa2b8ca9235a7291ee41d976b886fec185835d
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GAL3ST1 ABCB6 BLK SNX25 HAAO TTC13

1.04e-0515913861dde4d19cc0fde7ebbccb4c31bb845a92206021b
ToppCelldroplet-Mammary_Gland-nan-21m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 GPR35 ITGAX F13A1 MMP9 MMP13

1.11e-051611386787f91f906756ef570c0d02936c3cdfafb3f7454
ToppCelldroplet-Mammary_Gland-nan-21m-Myeloid|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 GPR35 ITGAX F13A1 MMP9 MMP13

1.11e-0516113863db97af49520dc8cbafb4454d8afd9d588160e89
ToppCelldroplet-Mammary_Gland-nan-21m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 GPR35 ITGAX F13A1 MMP9 MMP13

1.11e-051611386f1d258c81bcf0f3c52bd20aa58faa9a5fd888168
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ISYNA1 CYP2C18 CYP2J2 CBLC PPL MMP13

1.15e-051621386112fa4de685727f6c8bf6fc4afb82de0524070ad
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RRP1B INTS10 SLC7A3 MEGF8 SLC35F3 CHD5

1.19e-051631386953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAN2B2 SPIRE1 SFI1 USP39 ESPL1 ADGRL3

1.47e-0516913867cb1b87be66a22fe5731bb1b55bc515920fe3e8b
ToppCell390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|390C / Donor, Lineage, Cell class and subclass (all cells)

TBXAS1 DSC2 SUCNR1 F13A1 CD93 CARD9

1.47e-0516913862c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCelldroplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX9 SOX10 LAMA1 MYOF SLC35F3 TOP2A

1.62e-051721386c0bda7153e02bee7d0326138cc684151c404c2a1
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CASS4 IGF2-AS LAMA1 XPNPEP2 OSGIN1

1.66e-0510213850bbc6344d0baee47326a16a89773bb5c68a7b040
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CASS4 IGF2-AS LAMA1 XPNPEP2 OSGIN1

1.66e-05102138511fbdb428824023603e9d4ee41e957ba84e7c29e
ToppCellfacs-Aorta-Heart-24m-Myeloid-macrophage|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RRP1B GPR35 ITGAX PMVK CARD9 ESPL1

1.67e-051731386d0d1c8bcef3d9c28ee9a7c64076624b836cb2580
ToppCell368C-Lymphocytic-NK_cells-NK_cell_C|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DSC2 RTEL1 SPIRE1 CD93 MGAT5 CARD9

1.97e-05178138650bb1f2c6a8d050ff2af217fd76c3b1b7b4a4a69
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A34 CBLC F13A1 HHATL PHYH PAX3

2.03e-0517913867ae67e1c09a4ce9b3bcec4c48ee9cf2b1cb4e339
ToppCellsevere-Myeloid-Neutrophils_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CASS4 TBXAS1 PGGHG ITGAX KATNBL1 PLXNC1

2.30e-05183138660a6112aa4fc4f5debda4c7e81b37539ba2e4e6e
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAX MGAT5 CARD9 HAAO IL2RB TOP2A

2.44e-051851386969248b63d4ce335f223528de756bcddffadbd77
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|normal_Lymph_Node / Location, Cell class and cell subclass

SUCNR1 ITGAX F13A1 CD93 CARD9 MMP9

2.67e-051881386e83de94a9b47a6a90e98face887eae031a322af6
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CASS4 TBXAS1 SUCNR1 ITGAX F13A1 MMP9

2.75e-051891386b491204cf38dc80a2583e3082a82dda8d77b3fc4
ToppCellControl-Myeloid-cMonocyte|Control / Disease state, Lineage and Cell class

TBXAS1 MYO9B ITGAX F13A1 CD93 PLXNC1

3.01e-051921386ad04c9c4bdebf94615cee1904ca48197e62c923b
ToppCellControl-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

TBXAS1 MYO9B ITGAX F13A1 CD93 PLXNC1

3.19e-051941386f852f5258617a66a4fbd56d64c7b47272e7b8b60
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D231|Adult / Lineage, Cell type, age group and donor

CASS4 TBXAS1 MYO9B ITGAX F13A1 PLXNC1

3.19e-051941386800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ESF1 BLK SNX25 IL2RB PCK2 PTCD3

3.38e-051961386fd756b247b2d8a291e8e71bec6f1e463d6557536
ToppCellCOVID-19-kidney-Macrophages|COVID-19 / Disease (COVID-19 only), tissue and cell type

TBXAS1 MYO9B ITGAX F13A1 PLXNC1 MMP9

3.47e-0519713863912301018d0863144dcfac8d1fa8adc081748d7
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TBXAS1 ITGAX F13A1 CARD9 PLXNC1 MMP9

3.47e-051971386e698a0bbb20bd4868ff4348f2ac9f609942b55fa
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

ANKRD13D TBXAS1 MYO9B ITGAX F13A1 PLXNC1

3.57e-051981386d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CCL|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TBXAS1 ITGAX CACNA2D4 CARD9 PLXNC1 MMP9

3.67e-051991386c72279fa3ca2ebc42a1446507673df154b8033c7
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

IGF2-AS LAMA1 XPNPEP2 ALX4 OSGIN1

5.71e-051321385560e836764ed7806fb18282dfebe434d30112a9a
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 TGM6 F13A1 CARD9 MMP9

6.82e-051371385587a369b148bb2600c06db39298feddfc99cb6ad
ToppCelldroplet-Liver-LIVER_NPC-30m-Epithelial-Hepatocyte_(Midlobular)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINA12 PHYH PMVK PAX8 HAAO

7.30e-051391385e363c69b58cff8571ca75b91a3d052f9cbccac27
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD13D BLK PRIM2 MPPE1 BRWD1

8.08e-051421385a88bf4bcc80206b16dcc504cc19a3380d01e34a4
ToppCelldroplet-Bladder-nan-3m-Hematologic-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 GPR35 F13A1 CARD9 MMP13

1.08e-041511385a7b1a60d68f0ed17022fe4c97af64f9f08d39fa3
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TBXAS1 MAN2B2 SPIRE1 F13A1 MMP13

1.18e-04154138579ebda35dd1719e157738d7c13e5b8ccc3991f03
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IGF2-AS LAMA1 ALX4 AEBP1 OSGIN1

1.18e-04154138565dbb60f636562eeba3dafadae9c0c7db2b27476
ToppCell368C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SOX9 DDI2 XPNPEP2 PLXNC1 TOP2A

1.26e-0415613854877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-fibrocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCB7 GPR35 SSTR4 CARD9 PLXNC1

1.26e-0415613855b56217336771baf57d791efcb4e206c6aea83b1
ToppCell368C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SOX9 DDI2 XPNPEP2 PLXNC1 TOP2A

1.26e-0415613851d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR35 SPIRE1 SFI1 ITGAX SNX25

1.29e-041571385ec433d2fe827abdb647be4176c231b7052482b6f
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

IGF2-AS LAMA1 XPNPEP2 ALX4 OSGIN1

1.37e-041591385cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB19 ITGAX MGAT5 IL2RB BAIAP3

1.50e-0416213850321fc954ae4ad67ca438cbbc84632562d222188
ToppCell368C-Fibroblasts-Fibroblast-E|368C / Donor, Lineage, Cell class and subclass (all cells)

ABCB6 XPNPEP2 HHATL BMP1 ZNF252P-AS1

1.50e-041621385e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell368C-Fibroblasts-Fibroblast-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

ABCB6 XPNPEP2 HHATL BMP1 ZNF252P-AS1

1.50e-041621385ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB19 ITGAX MGAT5 IL2RB BAIAP3

1.50e-0416213855731f9514434296132df4bc86f78ce87b07cdeca
ToppCellfacs-MAT-Fat-3m-Myeloid-myeloid_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 F13A1 CD93 MMP9 MMP13

1.54e-0416313855fc836444bc156c8248abee001b0ecbe43f980c9
ToppCellC_02|World / shred on cell type and cluster

XPNPEP2 USP2 PCK1 PCK2 OSGIN1

1.63e-041651385a456c2c9ffe8dc91e17cac84ba87b88e016f8e6d
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-fibrocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 F13A1 BLK CARD9 MMP9

1.63e-0416513858a52f2dbcbd2bc1662b5e3fac381463fdcc3bf14
ToppCellfacs-MAT-Fat-18m-Myeloid|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 GPR35 ITGAX F13A1 MMP9

1.68e-0416613859116be2805c34881debb999d8417e43832fcf2f2
ToppCellfacs-MAT-Fat-18m-Myeloid-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 GPR35 ITGAX F13A1 MMP9

1.68e-0416613855c2667da79935f3d4b1edbfe7a10e7dbc2fa3ad0
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CASS4 GPR35 ITGAX HAAO

1.69e-04891384a4c2e364f8017dd9631f5ef06bdabdb2ebed1db8
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)--|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CASS4 GPR35 ITGAX HAAO

1.69e-04891384c9c3fce307f14e90cc0d24e9611c454010a60869
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-MICROGLIA_Microglia.C1qb.Tmem119_(Microglia.C1qb.Tmem119)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CASS4 GPR35 ITGAX HAAO

1.69e-048913842e5da863e68a8fe378a34b67e4703013b731a7a4
ToppCellfacs-Aorta-Heart-24m-Myeloid-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RRP1B GPR35 PMVK CARD9 ESPL1

1.73e-041671385b85fd7ab21c80470bca804c788ce49a2bce763f8
ToppCelldroplet-Liver-HEPATOCYTES-1m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD13D BLK ZNF22 IL2RB BAIAP3

1.83e-041691385d721dbb317a88113b4f76688111908d00f23e899
ToppCellfacs-Trachea-nan-18m-Myeloid-macrophage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 GPR35 ITGAX F13A1 HAAO

1.83e-041691385c6ae131f0bfb757541322691311139fae8bdca21
ToppCellCV-Mild-7|CV / Virus stimulation, Condition and Cluster

IARS1 HDX SPIRE1 BMP1 ZNF252P-AS1

1.88e-04170138525ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCellileum|World / shred on tissue and cell subclass

CYP2C18 DSC2 XPNPEP2 PCK2 OSGIN1

1.88e-0417013859f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCellcontrol-Myeloid-Monocyte-derived_Macrophage|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TBXAS1 GPR35 ITGAX CACNA2D4 MMP9

1.93e-041711385e828b684744a4fdf6b63ec033c4f000b39ca0d51
ToppCellfacs-Liver-Non-hepatocytes-3m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETFDH SERPINA12 PHYH HAAO PCK1

1.98e-041721385feaaf8ca7983d04a59ed0a7b3fb0e6d4b3a055f2
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR35 SUCNR1 BLK PLXNC1 HAAO

1.98e-041721385356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Liver-Non-hepatocytes-3m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETFDH SERPINA12 PHYH HAAO PCK1

1.98e-0417213859adfb4a65669cc536343616637058d0a4728013f
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR35 SUCNR1 BLK PLXNC1 HAAO

1.98e-04172138546fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellfacs-Liver-Non-hepatocytes-3m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETFDH SERPINA12 PHYH HAAO PCK1

1.98e-0417213858aed9c113f27d00401c272a3684495a4bc75bd0f
ToppCellfacs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CASS4 TBXAS1 GPR35 ITGAX HAAO

1.98e-041721385eaba10a4d4eaab42ad2e2da65ebb20b50edaf815
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR35 SUCNR1 BLK PLXNC1 HAAO

1.98e-041721385438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCelldroplet-Lung-nan-21m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNMA1 MAN2B2 ITGAX PLXNC1 PRIM2

2.04e-0417313852eb6e9fc3a3654f6f86fbd112e80a18814afd103
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SARM1 LAMA1 USP2 FAM120C

2.04e-04173138523e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCellCV-Mild-7|Mild / Virus stimulation, Condition and Cluster

IARS1 HDX SPIRE1 BMP1 ZNF252P-AS1

2.04e-041731385c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNMA1 ITGAX HAAO PCK1 TOP2A

2.04e-0417313856c9ecf77d2fb0f89100fdd7e4e88f85598278bc7
ToppCellASK428-Immune-B_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

SOX9 HDX KATNBL1 BBC3 TOP2A

2.09e-041741385b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCellNS-control-d_0-4-Myeloid-Monocyte-derived_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TBXAS1 GPR35 ITGAX CACNA2D4 MMP9

2.09e-041741385758984730cd1c3ccf6866a3a8f03d6e002f3edb6
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DSC2 SPTBN2 CACNA2D4 RUNDC3A SLC35F3

2.15e-0417513858362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DSC2 SPTBN2 CACNA2D4 RUNDC3A SLC35F3

2.15e-0417513858b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CASS4 GPR35 ITGAX PLXNC1 MMP9

2.26e-041771385f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCellsevere-Myeloid-Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CASS4 TBXAS1 PGGHG ITGAX KATNBL1

2.26e-041771385d1ad35ee3d2a84b1d01126d0a38464ab858c00d0
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TBXAS1 RTEL1 CARD9 CHD5 TOP2A

2.26e-0417713851d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TBXAS1 ITGAX MYOF KLHDC4 TOP2A

2.26e-04177138567cc3a6461db5e0678f96b18224aeb83ad34b0f4
ToppCellEndothelial-Endothelial-C|Endothelial / shred on cell class and cell subclass (v4)

CD93 DUOX1 ZNF22 MYH15 USP39

2.26e-041771385b5b9278dfd76b1aacd88e5fe86e91a2c9b565f87
ToppCellDendritic_Cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

TBXAS1 F13A1 CD93 CACNA2D4 PLXNC1

2.32e-04178138561ce3ec64c4cffceac08412e20c26e9c90ab8197
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

RAB19 IGF2-AS DSC2 XPNPEP2

2.35e-049713842cd5cafdf0a9a468baaafd4613d790fc048ee53e
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

RAB19 IGF2-AS DSC2 XPNPEP2

2.35e-04971384adda7a49b7754ed110e212346768bf52107c26fc
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

RAB19 IGF2-AS DSC2 XPNPEP2

2.35e-049713846d865ec3a413f595de17e0a5f8c61666ebb3e252
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX9 GAL3ST1 SPTBN2 HHATL AEBP1

2.45e-041801385fc5b9d0e3215652e490ca72d69f776e9725608b2
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

ACACA SPIRE1 BMP1 DUOX1 SNX25

2.45e-041801385198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellSevere-B_memory-3|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TBXAS1 TERF2 BLK BBC3 BAIAP3

2.45e-04180138590b812c5450359b1745b413421b71e291c97086a
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX9 GAL3ST1 SPTBN2 HHATL AEBP1

2.45e-0418013856763b22f2383931c747b37cd0ae2f60b08f64d90
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEL1L TBXAS1 CASP10 BLK PLXNC1

2.51e-0418113856cdee2f56bc633b387b4dbbd78c624edbd712c24
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEL1L TBXAS1 CASP10 BLK PLXNC1

2.51e-041811385b75b8b025257bccfe661fd0f92ab284b2a9c12ee
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC2 ABCB6 DDI2 SUCNR1 BMP1

2.57e-041821385770ce9f3f4538d0181a0181543841bc964c68274
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

OR2J3 TGM6 RUNDC3A PAX3 BAIAP3

2.57e-0418213850e589bf97d51b4b2f723f8c45853ad81b7ce8778
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBXAS1 ITGAX MYOF CHD5 KLHDC4

2.57e-0418213853dec003bad0f3716cf8163861a9d4302a7d6df8c
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TBXAS1 ITGAX F13A1 PLXNC1 MMP9

2.57e-041821385ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC2 ABCB6 DDI2 SUCNR1 BMP1

2.57e-04182138577ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC2 ABCB6 DDI2 SUCNR1 BMP1

2.57e-0418213854921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TBXAS1 MMP21 ITGAX F13A1 CACNA2D4

2.64e-041831385a97f052950429245c3231464271e1ba539863bba
ToppCelldroplet-Heart-nan-18m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 GAL3ST1 CBLC CHD5 PCK1

2.64e-0418313851701c8c212f1fdb6e4764375542a203e19753d14
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC2 ABCB6 DDI2 SUCNR1 BMP1

2.64e-041831385d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX9 GAL3ST1 SPIRE1 USP2 AEBP1

2.64e-041831385f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCell3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ISYNA1 GAL3ST1 RUNDC3A SLC35F3 BAIAP3

2.64e-04183138549f3ddc1c7c04b4ca837dbd6dad995add82941d6
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

LAMA1 XPNPEP2 ALX4 AEBP1 OSGIN1

2.71e-041841385235890e8b424f4386b6ea52d173d20a00898df73
ComputationalGenes in the cancer module 210.

BMP1 AEBP1 MMP9 MMP13

6.16e-0528844MODULE_210
DrugGraveoline [485-61-0]; Up 200; 14.4uM; PC3; HT_HG-U133A

TBXAS1 ZSWIM8 ATP9B SFI1 CD93 BMP1 MGAT5 SYCP1 BBC3 HRH3

2.87e-07194137103716_UP
DrugDehydroisoandosterone 3-acetate [853-23-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A

SOX9 ZSWIM8 PGGHG RTEL1 CASP10 ATP9B BMP1 BBC3 OSGIN1

2.87e-0619513796474_UP
Drugdexamethasone; Up 200; 1uM; MCF7; HG-U133A

PDE6D MAN2B2 MYO9B SFI1 BMP1 MYOF GANAB PAX8 BAIAP3

3.26e-061981379123_UP
Drugchloroacetaldehyde

TBXAS1 IARS1 SARM1 NARS1 PIDD1 ABCB6 YEATS2 BBC3 TOP2A OSGIN1

1.74e-0530713710ctd:C004656
DrugIfosfamide

TBXAS1 CYP2C18 IARS1 PIDD1 ABCB6 YEATS2 MMP9 TOP2A OSGIN1

1.99e-052481379ctd:D007069
DrugNifuroxazide [965-52-6]; Up 200; 14.6uM; MCF7; HT_HG-U133A

SPTBN2 SFI1 CRY1 BMP1 TSPAN31 BAIAP3 PCK2 OSGIN1

2.27e-0519313784835_UP
DrugFlucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A

OCA2 SFI1 BMP1 USP2 RUNDC3A PLXNC1 IL2RB ADGRL3

2.35e-0519413786507_UP
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A

SEL1L ABCB7 DSC2 RRP1B BCKDHA PPL BMP1 MGAT5

2.44e-0519513787444_DN
DrugMiconazole [22916-47-8]; Up 200; 9.6uM; MCF7; HT_HG-U133A

SFI1 ALX4 AEBP1 PAX8 HAAO GNAS BAIAP3 OSGIN1

2.44e-0519513784960_UP
DrugPhensuximide [86-34-0]; Up 200; 21.2uM; PC3; HT_HG-U133A

RTEL1 SARM1 PIDD1 SFI1 BMP1 FAM120C CHD5 BRWD1

2.53e-0519613785097_UP
DrugAnabasine [494-52-0]; Down 200; 24.6uM; HL60; HT_HG-U133A

PIDD1 CASP10 SFI1 F13A1 BMP1 FAM120C MYH15 MMP9

2.53e-0519613782512_DN
DrugGemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A

SOX10 SYCP1 NGF HAAO PAX3 MMP13 BAIAP3 ADGRL3

2.53e-0519613782277_UP
Drugstaurosporine; Down 200; 0.01uM; SKMEL5; HG-U133A

SEL1L SOX10 SMARCA5 ACACA CASP10 CHD9 PAX3 MPPE1

2.53e-051961378508_DN
Drug(-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; PC3; HT_HG-U133A

RTEL1 SARM1 PIDD1 ATP9B MYOF FAM120C BBC3 SNRNP200

2.72e-0519813785108_UP
DrugPropofol [2078-54-8]; Up 200; 22.4uM; PC3; HT_HG-U133A

CASS4 SOX10 ZSWIM8 OCA2 SFI1 HAAO BBC3 OSGIN1

2.72e-0519813786707_UP
Drugpioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A

SOX9 PGGHG RRP1B RTEL1 SARM1 CASP10 BMP1 PCK1

2.72e-0519813785972_DN
DrugPregnenolone [145-13-1]; Up 200; 12.6uM; PC3; HT_HG-U133A

CASS4 TBXAS1 GAL3ST1 BLK USP2 RUNDC3A CARD9 PCK1

2.72e-0519813784218_UP
DrugPhenformin hydrochloride [834-28-6]; Up 200; 16.6uM; MCF7; HT_HG-U133A

SOX10 MYO9B CASP10 SFI1 ALX4 BMP1 USP2 MGAT5

2.72e-0519813783622_UP
DrugCromolyn disodium salt [15826-37-6]; Up 200; 7.8uM; PC3; HT_HG-U133A

SEL1L DSC2 GPR35 OCA2 BMP1 USP2 PLXNC1 SYCP1

2.82e-0519913785754_UP
DrugBenzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A

SOX10 PGGHG RTEL1 SPTBN2 CASP10 SFI1 CARD9 PLXNC1

2.82e-0519913783169_UP
DrugTG-2

IARS1 BCKDHA TGM6 F13A1 BBC3

3.89e-05631375CID000574319
DrugCorn Oil

ACACA XPNPEP2 BMP1 PAX8 OSGIN1

6.05e-05691375ctd:D003314
DiseasePhosphoenolpyruvate carboxykinase deficiency

PCK1 PCK2

1.99e-0521322C0268194
DiseaseMetaphyseal anadysplasia

MMP9 MMP13

1.99e-0521322C0432226
DiseaseOvotesticular Disorders of Sex Development

SOX9 SRY

5.94e-0531322C2748895
Diseasepulmonary embolism (implicated_via_orthology)

TBXAS1 MMP9

5.94e-0531322DOID:9477 (implicated_via_orthology)
Diseasemeningococcal meningitis (biomarker_via_orthology)

MMP9 MMP13

5.94e-0531322DOID:0080176 (biomarker_via_orthology)
DiseaseTrue Hermaphroditism (disorder)

SOX9 SRY

5.94e-0531322C0266361
DiseaseColorectal Carcinoma

ACACA FRMPD2 SPTBN2 LAMA1 ETFDH ABCB6 CD93 MYLK3 PAX8 CHD5 GNAS SNRNP200

7.76e-0570213212C0009402
Diseasegastric ulcer (biomarker_via_orthology)

F13A1 MMP9 MMP13

1.10e-04211323DOID:10808 (biomarker_via_orthology)
Diseasepoly(A) polymerase gamma measurement

SARM1 SPDYC

1.18e-0441322EFO_0802878
Diseasegrb2-related adapter protein 2 measurement

SARM1 SPDYC

1.18e-0441322EFO_0020420
Diseaseserpin A12 measurement

SARM1 SERPINA12

1.97e-0451322EFO_0802061
Diseaseanodontia (is_implicated_in)

MMP9 MMP13

1.97e-0451322DOID:13714 (is_implicated_in)
DiseaseWaardenburg Syndrome

SOX10 PAX3

2.94e-0461322C3266898
Diseasearteriosclerosis (is_implicated_in)

F13A1 MMP9 MMP13

3.59e-04311323DOID:2349 (is_implicated_in)
DiseaseSwyer Syndrome

SOX9 SRY

4.11e-0471322C2936694
Diseasearteriosclerosis (implicated_via_orthology)

TBXAS1 MMP9

4.11e-0471322DOID:2349 (implicated_via_orthology)
Diseasedegenerative disc disease (implicated_via_orthology)

NGF MMP13

4.11e-0471322DOID:90 (implicated_via_orthology)
DiseaseGonadal Dysgenesis, 46,XY

SOX9 SRY

5.46e-0481322C0018054
Diseasebreast cancer anti-estrogen resistance protein 3 measurement

SARM1 JMJD1C

5.46e-0481322EFO_0008040
DiseaseCongenital Hand Deformities

SOX9 PAX3

5.46e-0481322C0018566
DiseaseCraniofacial Abnormalities

SOX9 ALX4 PAX3 MMP13 DCAF7

6.98e-041561325C0376634
Disease3-phenylpropionate hydrocinnamate measurement

LAMA1 SSTR1

8.73e-04101322EFO_0021010
Diseasegastrin-releasing peptide measurement

SARM1 JMJD1C

1.06e-03111322EFO_0022000
Disease46,XY partial gonadal dysgenesis

SOX9 SRY

1.06e-03111322C4510744
DiseaseAdenoid Cystic Carcinoma

ISYNA1 JMJD1C ESPL1 TOP2A

1.08e-031001324C0010606
DiseaseMalignant neoplasm of salivary gland

ISYNA1 ESPL1 TOP2A

1.08e-03451323C0220636
DiseaseSalivary Gland Neoplasms

ISYNA1 ESPL1 TOP2A

1.23e-03471323C0036095
DiseaseNeuroblastoma

CHD5 GNAS TOP2A

1.23e-03471323C0027819
Diseasesleep duration, triglyceride measurement

MYO9B JMJD1C INTS10 SLC35F3

1.25e-031041324EFO_0004530, EFO_0005271
Diseaseskin melanoma (is_implicated_in)

OCA2 MMP9

1.74e-03141322DOID:8923 (is_implicated_in)
Diseasesilicosis (biomarker_via_orthology)

RTEL1 MMP13

1.74e-03141322DOID:10325 (biomarker_via_orthology)
Diseasecongenital hypothyroidism (implicated_via_orthology)

DUOX1 PAX8

1.74e-03141322DOID:0050328 (implicated_via_orthology)
Diseasediabetic retinopathy (is_marker_for)

F13A1 NGF MMP9

1.84e-03541323DOID:8947 (is_marker_for)
DiseaseLiver Cirrhosis, Experimental

ISYNA1 XPNPEP2 CRY1 MGAT5 MMP9 MMP13 IL2RB PCK1 PCK2 OSGIN1

2.58e-0377413210C0023893
DiseaseTactile Amnesia

NGF HRH3

2.58e-03171322C0750906
DiseaseAmnestic State

NGF HRH3

2.58e-03171322C0750907
DiseaseDissociative Amnesia

NGF HRH3

2.58e-03171322C0236795
Diseasepartial epilepsy

SMARCA5 ADGRL3

2.58e-03171322EFO_0004263
DiseaseHysterical amnesia

NGF HRH3

2.58e-03171322C0233750
DiseaseTemporary Amnesia

NGF HRH3

2.58e-03171322C0233796
DiseaseAmnesia

NGF HRH3

2.58e-03171322C0002622
DiseaseGlobal Amnesia

NGF HRH3

2.58e-03171322C0262497
DiseaseDisorder of eye

OCA2 PRPF8 PHYH CACNA2D4 SNRNP200

2.70e-032121325C0015397
DiseaseGrand Mal Status Epilepticus

SSTR1 SSTR4 NGF

3.40e-03671323C0311335
DiseaseStatus Epilepticus, Subclinical

SSTR1 SSTR4 NGF

3.40e-03671323C0751522
DiseaseSimple Partial Status Epilepticus

SSTR1 SSTR4 NGF

3.40e-03671323C0751524
DiseaseNon-Convulsive Status Epilepticus

SSTR1 SSTR4 NGF

3.40e-03671323C0751523
DiseasePetit mal status

SSTR1 SSTR4 NGF

3.40e-03671323C0270823
DiseaseComplex Partial Status Epilepticus

SSTR1 SSTR4 NGF

3.40e-03671323C0393734
DiseaseStatus Epilepticus

SSTR1 SSTR4 NGF

3.55e-03681323C0038220
Diseaseautoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis

IGF2-AS GPR35 CARD9

3.85e-03701323EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Diseasegastric ulcer

MYO9B GNAS

3.94e-03211322EFO_0009454
DiseaseSclerocystic Ovaries

ISYNA1 ABCB6 GNAS TOP2A

4.06e-031441324C1136382
DiseasePolycystic Ovary Syndrome

ISYNA1 ABCB6 GNAS TOP2A

4.06e-031441324C0032460
Diseaserenal system measurement, blood urea nitrogen measurement

PAX8 GNAS

4.33e-03221322EFO_0004741, EFO_0004742

Protein segments in the cluster

PeptideGeneStartEntry
RAKWRKRERFGQMQQ

ALX4

266

Q9H161
EQWAREIGAQLRRMA

BBC3

131

Q9BXH1
MTWQRGRRSFIFKGQ

ANKRD13D

166

Q6ZTN6
AGLMLFVSRKWRFRD

CASS4

456

Q9NQ75
QWEEARALGRAVRML

CBLC

11

Q9ULV8
ARQRKAFLNAIMRWG

CHD5

1426

Q8TDI0
LIMSSGQAWKEQRRF

CYP2J2

126

P51589
MERRLGVRAWVKENR

HAAO

1

P46952
NMDIAAALKRGNREW

BAIAP3

561

O94812
ILARSNWKRIREIMA

AEBP1

981

Q8IUX7
VEAREIMWFKTRQGQ

ADGRL3

501

Q9HAR2
MEEKRRRARVQGAWA

ALKBH3

1

Q96Q83
RREAALTARMSKFWI

CD93

81

Q9NPY3
QARQRLAMGIWIKFR

ABCB6

131

Q9NP58
NGIAAVKCMRSIRRW

ACACA

126

Q13085
SQRAVFRQAMRHWEK

BMP1

146

P13497
RALRKMQKGWRQGEE

CARD9

506

Q9H257
AMNWSVRPDKRFRLA

DCAF7

21

P61962
RMWRLKAINDTAARL

DSC2

621

Q02487
VKMQVWDTAGQERFR

RAB19

66

A4D1S5
AVKAYRLSRGRVWAM

OCA2

411

Q04671
KRQNPTMFAWEIRDR

PAX8

96

Q06710
FALRMASRLAKEEGW

PCK1

246

P35558
GKAVIFTQVSRQWRM

ITGAX

431

P20702
NLAEAMRRAKVLDWG

ISYNA1

146

Q9NPH2
WERLFKILNVVGMRC

INTS10

256

Q9NVR2
NMSWIRGRRSFIFKG

ANKRD13A

166

Q8IZ07
LSAWIVARLRMRNFK

DUOX1

611

Q9NRD9
CNIMRLVDRRWAGVA

DDI1

276

Q8WTU0
RLWRFDVKAQMVDPR

MMP9

631

P14780
ILFLRAGRTQEAWKM

PTCD3

581

Q96EY7
AGRTQEAWKMLGLFR

PTCD3

586

Q96EY7
RNMRLNVALTFWRKR

KATNBL1

161

Q9H079
WIGNRRRKYRLMGIE

HDX

486

Q7Z353
RVRALFGAMNFWAII

HHATL

426

Q9HCP6
LTMDGKQAAWRFIRI

NGF

211

P01138
RIRRMADAWIQAIKS

MGAT5

241

Q09328
RMKRVWDRAVEFLAS

LEMD2

456

Q8NC56
RIMQRKRGLEWFVCD

ATP9B

76

O43861
AKIAWKRAVRGVREM

JMJD1C

1831

Q15652
QRFRRVAKDPRFWEM

ESF1

11

Q9H501
KLRREWQMERAFQTA

MPPE1

91

Q53F39
AWMRFDSEGRLRAIN

PCK2

331

Q16822
FRMSEIQARAKRVSW

PLXNC1

331

O60486
LRGETMIFKDRFFWR

MMP13

296

P45452
VADQRRIVALAFRMW

MMP21

191

Q8N119
KVADFLMQGRVPWRR

MYLK3

136

Q32MK0
RAGLIDWNMFVKLRS

PPL

1676

O60437
ERAREILRGFKLNWM

PDE6D

6

O43924
GFREVRKKMALWAAL

MEGF8

1751

Q7Z7M0
GKWRMLTDLRAVNAV

HERVK_113

81

P63132
QKVAWKRAVRGVREM

KDM3B

1016

Q7LBC6
WGAKIVMREDRSVRL

F13A1

131

P00488
RAPQMDWNRKREIFS

SLC9A3R2

321

Q15599
WLGKAVEDKNRRMRA

FAM120A

676

Q9NZB2
FAVGWMELKDAVRAR

PGGHG

541

Q32M88
VGQAEATRKAARMVW

GPR35

206

Q9HC97
ATRKAARMVWANLLV

GPR35

211

Q9HC97
GKWRMLTDLRAVNAV

ERVK-7

81

P63135
GKWRMLTDLRAVNAV

ERVK-6

81

Q9BXR3
RARWRKQAGANQLMA

PAX3

271

P23760
LRRWFIQQEMDLLRF

PRIM2

116

P49643
WRKVEAFGRERMARE

GAL3ST1

316

Q99999
RDKDKRWEGVNMERF

ETFDH

51

Q16134
RGQFDWTKFRAMARL

CHD9

1861

Q3L8U1
VTFWVRVKMDAARAG

ESPL1

546

Q14674
MSKRKWRGFRGAQQE

IGF2-AS

1

Q6U949
LIGREVSFADRMKWI

CACNA2D4

431

Q7Z3S7
SRIAMLRFQWRETGK

FRMPD2

581

Q68DX3
MERWFFRSQGRKEAE

BLK

121

P51451
VLTGNWMEERRKFTR

CFAP107

26

Q8N1D5
ERKAWVANFERPRMN

CRY1

226

Q16526
LWLGKAVEDKNRRMR

FAM120C

726

Q9NX05
REGVRWRVMAIQDFK

IL2RB

111

P14784
MFDVGGQRDERRKWI

GNAS

221

P63092
DINRKMLFLRGFRSW

BRWD1

2301

Q9NSI6
QGDTRRAVRKMLLVW

HRH3

146

Q9Y5N1
KAAMQEARGLQFVWR

MAN2B2

181

Q9Y2E5
RMVAWKRQLILFGGF

KLHDC4

181

Q8TBB5
MEIRGRKRTVWGAKQ

CASP10

481

Q92851
NGKRWKEIRRFCLMT

CYP2C18

116

P33260
MRLVDRRWAGIAKGV

DDI2

271

Q5TDH0
LGRMFWREENAKAAL

PNMA1

51

Q8ND90
MPWQAFRRFGQKLVR

SLC7A3

1

Q8WY07
DWMQKKRRGLRNSRA

OSGIN1

156

Q9UJX0
AEAARQRKGADALWM

PIDD1

736

Q9HB75
MAVAIAAARVWRLNR

BCKDHA

1

P12694
AWRKQSRRKVMEAFE

BCKDHA

381

P12694
KDIWMFRARLVKGER

PHYH

321

O14832
RNKVVRGAVKRLMGW

OR2J3

296

O76001
RRQWLQEAMSAAFRG

HSPBP1

71

Q9NZL4
ARAKGRAWIRVALME

RUNDC3A

121

Q59EK9
EFWRARDLARKMEAL

RTEL1

571

Q9NZ71
MRKARERWSFIRALH

WARS2

6

Q9UGM6
RVRAAEFHMAQLLRW

SFI1

606

A8K8P3
GALRRWKENTMARVD

SFI1

686

A8K8P3
RMVALKAGWQQRKRS

SSTR1

251

P30872
FLWRGNVVLRAQMIR

TRIM43

166

Q96BQ3
TMNREWKGIDRLRLD

RRP1B

101

Q14684
RFGELMRKLWNPRNF

USP39

276

Q53GS9
FGWVHRLRRQGKNLM

NARS1

131

O43776
MLFWDELRKLAGRAQ

SLC25A34

286

Q6PIV7
FKNVCERGRWSERLM

SEL1L

546

Q9UBV2
EIFELRGMFKWVRRT

SNX25

691

Q9H3E2
RMFKWLVARINRALD

MYH15

446

Q9Y2K3
MAAVAAVAARRRRSW

GANAB

1

Q14697
FLAVEMRRGRVAFLW

LAMA1

2166

P25391
GKMRAVALRAGWQQR

SSTR4

236

P31391
LLERQVKRRGDFLMW

SPATA31D4

411

Q6ZUB0
TNWYVRMNRRRLKGE

IARS1

731

P41252
WRAARMKSLEQDALR

SCRIB

1501

Q14160
AFMVWAQAARRKLAD

SOX9

111

P48436
RDVWVRVRGVFEKRM

OR6J1

301

Q8NGC5
AFRKDMIRWGEEKRQ

PMVK

71

Q15126
WIVLRDRFMGVRIVA

SLC35F3

196

Q8IY50
VQGWKQRMAAKELAR

SERPINA12

36

Q8IW75
VTRWRTRFRIEMNKA

ABCB7

311

O75027
GKWRMLTDLRAVNAV

ERVK-25

81

P63136
RLMKHDVNLGRAVFW

PRPF8

1141

Q6P2Q9
LLERQVKRRGDFLMW

SPATA31D3

411

P0C874
FLRDKRWEEVRGALM

TBXAS1

126

P24557
GLCREAWTKRNDMRL

TRIM77

356

I1YAP6
QWRDMFDIAVKWRRI

TTC13

561

Q8NBP0
CWFNVKEGRSRRRMT

XKR7

371

Q5GH72
LAARFDRKAAMRETW

SPTBN2

426

O15020
VQRRMVEKRAAEWLF

SARM1

241

Q6SZW1
GAIRKMREDRWAVIA

SYCP1

946

Q15431
QRDKLWARMGFRAVV

SPDYC

151

Q5MJ68
RFWVQVMRDLRNGVK

SPIRE1

271

Q08AE8
FMVWAQAARRKLADQ

SOX10

111

P56693
GKWRMLTDLRAVNAV

ERVK-8

81

P63133
EILGVWLAMRFRNQK

TSPAN31

186

Q12999
GKWRMLTDLRAVNAV

ERVK-11

81

Q9UQG0
MRNVRIASRLGSWKQ

SUCNR1

251

Q9BXA5
LMRAIFEIVLNRGWA

SNRNP200

1091

O75643
RKEWLTNFMEDRRQR

TOP2A

661

P11388
GVWNLLSIVREMFKR

ZSWIM8

346

A7E2V4
GLTRMERKAARLQWD

ZNF252P-AS1

181

Q0IIN9
TGRQRQKWGMTIRFD

ZNF22

26

P17026
AFIVWSRDQRRKMAL

SRY

66

Q05066
GKWRMLTDLRAVNAV

ERVK-19

81

Q9WJR5
RMVEAFARRALWDAG

XPNPEP2

501

O43895
IKEVRIMRWFGLVSR

TMEM217

121

Q8N7C4
DWFLKSRTAMELQRR

SMARCA5

986

O60264
GRQMWRKYLEREDSR

USP2

396

O75604
MAGIRVTKVDWQRSR

TGM6

1

O95932
FVNRTAVMIKDRWRT

TERF2

521

Q15554
NIGKRRAAEWQRAMT

YEATS2

1186

Q9ULM3
AVFRWAVLRAAIRAM

MYO9B

681

Q13459
IIWMIRGEKRLAYAR

MYOF

776

Q9NZM1