Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium:sodium symporter activity	SLC12A1 SLC12A2	1.62e-05	3	47	2	GO:0009674
GeneOntologyMolecularFunction	sodium:potassium:chloride symporter activity	SLC12A1 SLC12A2	1.62e-05	3	47	2	GO:0008511
GeneOntologyMolecularFunction	potassium:chloride symporter activity	SLC12A1 SLC12A2	1.93e-04	9	47	2	GO:0015379
Domain	Na/K/Cl_cotranspt	SLC12A1 SLC12A2	6.47e-06	2	48	2	IPR002443
Domain	AA_permease_N	SLC12A1 SLC12A2	1.94e-05	3	48	2	IPR013612
Domain	AA_permease_N	SLC12A1 SLC12A2	1.94e-05	3	48	2	PF08403
Domain	SLC12A_fam	SLC12A1 SLC12A2	1.35e-04	7	48	2	IPR004842
Domain	SLC12_C	SLC12A1 SLC12A2	1.79e-04	8	48	2	IPR018491
Domain	SLC12	SLC12A1 SLC12A2	1.79e-04	8	48	2	PF03522
Domain	FERM-adjacent	EPB41L5 EPB41	4.95e-04	13	48	2	IPR014847
Domain	FA	EPB41L5 EPB41	4.95e-04	13	48	2	SM01195
Domain	FA	EPB41L5 EPB41	4.95e-04	13	48	2	PF08736
Domain	CNH	MAP4K4 MINK1	5.77e-04	14	48	2	SM00036
Domain	CNH	MAP4K4 MINK1	6.65e-04	15	48	2	PF00780
Domain	CNH	MAP4K4 MINK1	6.65e-04	15	48	2	PS50219
Domain	CNH_dom	MAP4K4 MINK1	6.65e-04	15	48	2	IPR001180
Domain	Ez/rad/moesin-like	EPB41L5 EPB41	1.32e-03	21	48	2	IPR000798
Domain	AA-permease/SLC12A_dom	SLC12A1 SLC12A2	1.45e-03	22	48	2	IPR004841
Domain	AA_permease	SLC12A1 SLC12A2	1.45e-03	22	48	2	PF00324
Domain	FERM_CS	EPB41L5 EPB41	1.72e-03	24	48	2	IPR019747
Domain	Ricin_B_lectin	GALNT5 GALNT2	1.87e-03	25	48	2	PF00652
Domain	FERM_C	EPB41L5 EPB41	2.02e-03	26	48	2	PF09380
Domain	FERM_C	EPB41L5 EPB41	2.18e-03	27	48	2	SM01196
Domain	FERM_PH-like_C	EPB41L5 EPB41	2.18e-03	27	48	2	IPR018980
Domain	RICIN	GALNT5 GALNT2	2.34e-03	28	48	2	SM00458
Domain	RICIN_B_LECTIN	GALNT5 GALNT2	2.34e-03	28	48	2	PS50231
Domain	Ricin_B_lectin	GALNT5 GALNT2	2.69e-03	30	48	2	IPR000772
Domain	Glycos_transf_2	GALNT5 GALNT2	2.69e-03	30	48	2	PF00535
Domain	Glyco_trans_2-like	GALNT5 GALNT2	2.69e-03	30	48	2	IPR001173
Domain	FERM_N	EPB41L5 EPB41	3.25e-03	33	48	2	PF09379
Domain	FERM_N	EPB41L5 EPB41	3.25e-03	33	48	2	IPR018979
Domain	PH_dom-like	RGPD1 EPB41L5 CMIP RAPH1 EPB41	4.61e-03	426	48	5	IPR011993
Domain	FERM_M	EPB41L5 EPB41	6.23e-03	46	48	2	PF00373
Domain	HEAT	HEATR1 GCN1	6.77e-03	48	48	2	PF02985
Domain	-	EPB41L5 EPB41	7.04e-03	49	48	2	1.20.80.10
Domain	FERM_central	EPB41L5 EPB41	7.04e-03	49	48	2	IPR019748
Domain	FERM_domain	EPB41L5 EPB41	7.04e-03	49	48	2	IPR000299
Domain	FERM_1	EPB41L5 EPB41	7.32e-03	50	48	2	PS00660
Domain	FERM_2	EPB41L5 EPB41	7.32e-03	50	48	2	PS00661
Domain	FERM_3	EPB41L5 EPB41	7.32e-03	50	48	2	PS50057
Domain	Band_41_domain	EPB41L5 EPB41	7.32e-03	50	48	2	IPR019749
Domain	B41	EPB41L5 EPB41	7.32e-03	50	48	2	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	EPB41L5 EPB41	7.32e-03	50	48	2	IPR014352
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A1 SLC12A2	1.55e-04	7	39	2	M27339
Pathway	REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS	SLC12A1 SLC12A2	1.55e-04	7	39	2	MM15081
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	EPB41L5 HEATR1 DDX17 ARHGAP35 RAPH1 GCN1 SMCHD1 EPB41	3.81e-07	498	48	8	36634849
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NSD1 HEATR1 ARHGAP35 RAPH1 MAP4K4 GCN1 SMCHD1 EPB41	7.94e-07	549	48	8	38280479
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	EPB41L5 TNFRSF10B SLC12A2 RAPH1 MAP4K4 EPB41 MINK1	8.36e-07	377	48	7	38117590
Pubmed	The Na-K-Cl cotransporters.	SLC12A1 SLC12A2	1.87e-06	2	48	2	9672238
Pubmed	Transcription elongation factor hSPT5 stimulates mRNA capping.	RNGTT SUPT5H	1.87e-06	2	48	2	10421630
Pubmed	Expression of the basolateral Na-K-Cl cotransporter during mouse nephrogenesis and embryonic development.	SLC12A1 SLC12A2	1.87e-06	2	48	2	16814616
Pubmed	Molecular cloning and chromosome localization of a putative basolateral Na(+)-K(+)-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells.	SLC12A1 SLC12A2	1.87e-06	2	48	2	7929272
Pubmed	Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice.	SLC12A1 SLC12A2	1.87e-06	2	48	2	26400961
Pubmed	Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2.	SLC12A1 SLC12A2	1.87e-06	2	48	2	8640224
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PHF2 NOC4L SCPEP1 HEATR1 DDX17 GALNT5 MAP4K4 GCN1 SUPT5H SMCHD1 HEXIM1	2.94e-06	1425	48	11	30948266
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NSD1 EPB41L5 PHF2 NOC4L HEATR1 RNGTT SLC12A2 RPP40 EPB41 HEXIM1 MINK1	4.71e-06	1497	48	11	31527615
Pubmed	Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.	SLC12A1 SLC12A2	5.59e-06	3	48	2	8663127
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NOC4L HEATR1 DDX17 GALNT2 SLC12A2 MAP4K4 GCN1 SUPT5H SMCHD1	9.59e-06	1024	48	9	24711643
Pubmed	Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.	SLC12A1 SLC12A2	1.12e-05	4	48	2	21972418
Pubmed	Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia.	SLC12A1 SLC12A2	1.12e-05	4	48	2	20819979
Pubmed	Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.	SLC12A1 SLC12A2	1.12e-05	4	48	2	22989884
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PHF2 NOC4L RINT1 RNGTT SLC12A2 RAPH1 GCN1 SUPT5H MINK1	1.16e-05	1049	48	9	27880917
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	RGPD1 DNAJB6 NOC4L HEATR1 GCN1 SMCHD1	1.17e-05	370	48	6	22922362
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	GALNT5 GALNT2 HAPLN1	1.71e-05	36	48	3	25615642
Pubmed	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.	GPC6 GLCE HAPLN1	1.85e-05	37	48	3	32201365
Pubmed	Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.	SUPT5H HEXIM1	2.79e-05	6	48	2	14580347
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	SLC12A2 MAP4K4 EPB41 MINK1	2.91e-05	127	48	4	30442766
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	RGPD1 DNAJB6 DDX17 MAP4K4 MTERF1 SUPT5H SMCHD1	3.38e-05	665	48	7	30457570
Pubmed	Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.	SUPT5H HEXIM1	3.90e-05	7	48	2	15201869
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	NSD1 PHF2 HEATR1 BRIP1 DDX17 ARID4B SMCHD1 EPB41	4.44e-05	954	48	8	36373674
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	EPB41L5 HEATR1 BRIP1 ARHGAP35 RAPH1 EPB41	4.58e-05	472	48	6	38943005
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DNAJB6 EPB41L5 DDX17 MAP4K4 GCN1 EPB41 MINK1	5.01e-05	708	48	7	39231216
Pubmed	Structural diversity of band 4.1 superfamily members.	EPB41L5 EPB41	5.19e-05	8	48	2	7983158
Pubmed	Similar effects of all WNK3 variants on SLC12 cotransporters.	SLC12A1 SLC12A2	5.19e-05	8	48	2	21613606
Pubmed	Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development.	GALNT5 GALNT2	5.19e-05	8	48	2	11159923
Pubmed	Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).	SLC12A1 SLC12A2	5.19e-05	8	48	2	12386165
Pubmed	Calcium signaling induces partial EMT and renal fibrosis in a Wnt4mCherry knock-in mouse model.	SLC12A1 SLC12A2 TRPC6	5.51e-05	53	48	3	38653356
Pubmed	Cation-chloride cotransporters and neuronal function.	SLC12A1 SLC12A2	6.67e-05	9	48	2	19323993
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	EPB41L5 UGT8 DDX17 ARHGAP35 MTERF1 SMCHD1	7.26e-05	513	48	6	25798074
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	NOC4L MTBP HEATR1 SLC12A1 ARID4B MAP4K4 GCN1 GLCE HEXIM1	7.30e-05	1327	48	9	32694731
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NOC4L HEATR1 DDX17 RNGTT ARID4B GCN1 SMCHD1	7.75e-05	759	48	7	35915203
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	EPB41L5 DDX17 RNGTT SLC12A2 GCN1 EPB41 MINK1	8.97e-05	777	48	7	35844135
Pubmed	Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.	GPC6 HAPLN1	1.02e-04	11	48	2	38750698
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PHF2 NOC4L DDX17 ARHGAP35 GPC6 MAP4K4 GCN1 SUPT5H	1.07e-04	1082	48	8	38697112
Pubmed	The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.	MAP4K4 MINK1	1.22e-04	12	48	2	35027733
Pubmed	Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.	MYH6 HCN2	1.22e-04	12	48	2	17482496
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	BRIP1 DDX17 GCN1 SUPT5H SMCHD1	1.32e-04	357	48	5	37059091
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RGPD1 DNAJB6 MYH6 RINT1 HEATR1 DDX17 RAPH1 SMCHD1 TMEM135	1.37e-04	1442	48	9	35575683
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	HEATR1 ARID4B	1.68e-04	14	48	2	11472062
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DNAJB6 EPB41L5 SLC12A2 RAPH1 MAP4K4 EPB41 MINK1	1.69e-04	861	48	7	36931259
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJB6 EPB41L5 NOC4L RINT1 HEATR1 TNFRSF10B SLC12A2 MAP4K4 MINK1	1.73e-04	1487	48	9	33957083
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	HEATR1 DDX17 GCN1 SMCHD1	1.76e-04	202	48	4	24639526
Pubmed	Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle.	BRIP1 HAPLN1	1.94e-04	15	48	2	37227818
Pubmed	Rap2A links intestinal cell polarity to brush border formation.	MAP4K4 MINK1	1.94e-04	15	48	2	22797597
Pubmed	Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.	MYH6 MAP4K4	1.94e-04	15	48	2	36207400
Pubmed	Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.	DNAJB6 DDX17 GCN1	2.02e-04	82	48	3	30274258
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	UGT8 NOC4L RINT1 HEATR1 TNFRSF10B GALNT2 SLC12A2 GPC6	2.21e-04	1203	48	8	29180619
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	MAP4K4 GCN1 SUPT5H RPP40 MINK1	2.21e-04	399	48	5	37536630
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	ARHGAP35 RAPH1 GCN1 EPB41	2.27e-04	216	48	4	31519766
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	DNAJB6 PHF2 DDX17 ARID4B GPC6 SUPT5H SMCHD1	2.57e-04	922	48	7	27609421
Pubmed	Myosin-X recruits lamellipodin to filopodia tips.	DNAJB6 RAPH1 GCN1	2.58e-04	89	48	3	36861887
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RINT1 GALNT2 MAP4K4 SUPT5H HEXIM1 MINK1	2.62e-04	650	48	6	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NSD1 NOC4L HEATR1 GCN1 SUPT5H SMCHD1	2.69e-04	653	48	6	22586326
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	HEATR1 DDX17 ARHGAP35 RAPH1 GCN1 SMCHD1 EPB41	2.78e-04	934	48	7	33916271
Pubmed	The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.	NSD1 HEXIM1	2.81e-04	18	48	2	21030982
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	BRIP1 MAP4K4	3.14e-04	19	48	2	14578343
Pubmed	Lost in transcription: molecular mechanisms that control HIV latency.	SUPT5H HEXIM1	3.14e-04	19	48	2	23518577
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PHF2 MAP4K4 SMCHD1	3.85e-04	102	48	3	9734811
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CMIP ARHGAP35 RAPH1	3.85e-04	102	48	3	11214970
Pubmed	Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.	GPC6 GLCE	3.85e-04	21	48	2	26116392
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	HCN2 TRPC6	3.85e-04	21	48	2	30270038
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	NSD1 BRIP1 RNGTT SMCHD1 HEXIM1	3.96e-04	453	48	5	29656893
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	HEATR1 DDX17 GCN1 SUPT5H SMCHD1 EPB41	4.10e-04	707	48	6	19738201
Pubmed	Rare independent mutations in renal salt handling genes contribute to blood pressure variation.	SLC12A1 SLC12A2	4.23e-04	22	48	2	18391953
Pubmed	Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.	GALNT5 GALNT2	4.23e-04	22	48	2	25107907
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	EPB41L5 MAP4K4 EPB41	4.31e-04	106	48	3	38891874
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	HEATR1 RAPH1 GCN1 EPB41	4.33e-04	256	48	4	33397691
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	DNAJB6 NSD1 PHF2	4.67e-04	109	48	3	33554859
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	EPB41L5 SLC12A2 MAP4K4 GCN1	4.79e-04	263	48	4	34702444
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT5 GALNT2	5.05e-04	24	48	2	31740596
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT5 GALNT2	5.05e-04	24	48	2	31882545
Pubmed	Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.	RNGTT SUPT5H	5.48e-04	25	48	2	9790902
Pubmed	Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.	RNGTT SUPT5H	5.48e-04	25	48	2	9512541
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EPB41L5 PHF2 CMIP ARHGAP35 GLCE	5.81e-04	493	48	5	15368895
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	DNAJB6 HEATR1 GCN1	6.19e-04	120	48	3	27320910
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	DNAJB6 RNGTT GCN1 SUPT5H	6.22e-04	282	48	4	23667531
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BRIP1 ARHGAP35 ARID4B RAPH1 MAP4K4 MINK1	6.60e-04	774	48	6	15302935
Pubmed	The functional interactome landscape of the human histone deacetylase family.	DNAJB6 HEATR1 ARID4B GCN1	6.81e-04	289	48	4	23752268
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	NSD1 PHF2 HEATR1 DDX17 SMCHD1	8.25e-04	533	48	5	30554943
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RGPD1 DDX17 ARHGAP35 MAP4K4 GCN1 EPB41 MINK1	9.04e-04	1139	48	7	36417873
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	NSD1 PHF2	9.58e-04	33	48	2	26864203
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	HEATR1 ARID4B DCLRE1C SMCHD1 HEXIM1	9.65e-04	552	48	5	10737800
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	SLC12A2 RAPH1 GCN1 EPB41 MINK1	1.07e-03	565	48	5	25468996
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	RGPD1 DNAJB6 RINT1 RAPH1 MAP4K4 EPB41	1.09e-03	853	48	6	28718761
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	RINT1 SLC12A2 RAPH1 GCN1 EPB41	1.10e-03	568	48	5	37774976
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	EPB41L5 SLC12A2 MAP4K4 EPB41 MINK1	1.10e-03	569	48	5	30639242
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	NOC4L HEATR1 SUPT5H SMCHD1	1.14e-03	332	48	4	25693804
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	DDX17 GCN1 SUPT5H SMCHD1	1.14e-03	332	48	4	32786267
Pubmed	Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.	SUPT5H HEXIM1	1.14e-03	36	48	2	22422068
Pubmed	Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.	DNAJB6 DDX17 GCN1	1.20e-03	151	48	3	18457437
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	NSD1 PHF2 SMCHD1	1.32e-03	156	48	3	37108203
Interaction	ARL14 interactions	EPB41L5 RNGTT SLC12A2 EPB41 MINK1	8.30e-06	119	47	5	int:ARL14
Interaction	PROKR1 interactions	HEATR1 TNFRSF10B GCN1	1.54e-05	21	47	3	int:PROKR1
Interaction	H2BC21 interactions	NSD1 PHF2 MTBP ARID4B MAP4K4 SUPT5H SMCHD1 HEXIM1 TMEM135	2.79e-05	696	47	9	int:H2BC21
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT5 GALNT2	5.65e-04	20	32	2	433
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EPB41L5 EPB41	3.53e-03	50	32	2	1293
GeneFamily	PHD finger proteins	NSD1 PHF2	1.10e-02	90	32	2	88
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_1000	NSD1 EPB41L5 UGT8 DDX17 SLC12A1 GPC6 GCN1	2.14e-05	379	48	7	gudmap_developingKidney_e15.5_1000_k3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	EPB41L5 RNGTT ARHGAP35 ARID4B SLC12A2 RAPH1 DCLRE1C SMCHD1	5.09e-05	595	48	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
ToppCell	normal_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	PHF2 RINT1 HEATR1 RNGTT GALNT2	1.74e-06	187	48	5	a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	PHF2 RINT1 HEATR1 RNGTT GALNT2	1.74e-06	187	48	5	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	Globus_pallidus-Macroglia\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	UGT8 GALNT5 SLC12A2 MAP4K4	4.11e-05	179	48	4	ab50f711b004b96107f813c9a2526ec21d1c8027
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMIP GPC6 TRPC6 HAPLN1	4.20e-05	180	48	4	f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	ITPKC CMIP GALNT2 GPC6	5.08e-05	189	48	4	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A2 HCN2 GPC6 TRPC6	5.18e-05	190	48	4	bfbdf16d488359d7935a419c4c1823288f39c183
ToppCell	facs-Heart-RA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A2 HCN2 GPC6 TRPC6	5.18e-05	190	48	4	eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	NSD1 HEATR1 DDX17 SMCHD1	5.29e-05	191	48	4	9454f642c3621370fa23640b631301346b300950
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	DNAJB6 DDX17 ARID4B SMCHD1	5.40e-05	192	48	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	COVID-19_Mild-PLT_4\|World / Disease Group and Platelet Clusters	DNAJB6 DNAH12 ARID4B HEXIM1	5.51e-05	193	48	4	98a52523aa1efd5d14a2878ed106828a80a33aa2
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DDX17 ARID4B SMCHD1 EPB41	5.97e-05	197	48	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMIP GPC6 TRPC6 HAPLN1	6.08e-05	198	48	4	7582ee9ec8a87ecb094201f1f9191b412f9d2875
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DDX17 ARID4B SMCHD1 EPB41	6.33e-05	200	48	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Drug	Nifedipine [21829-25-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	DDX17 RNGTT SUPT5H GLCE HEXIM1 MINK1	3.20e-06	198	47	6	7303_DN
Drug	geldanamycin	EPB41L5 HEATR1 DDX17 GALNT5 RNGTT SMCHD1 TRPC6	1.03e-05	371	47	7	ctd:C001277
Drug	bromide;iodide	SLC12A1 SLC12A2	1.25e-05	3	47	2	CID009907214
Drug	Quinethazone	SLC12A1 SLC12A2	4.15e-05	5	47	2	DB01325
Drug	Bumetanide	SLC12A1 SLC12A2	4.15e-05	5	47	2	DB00887
Drug	Pipemidic acid [51940-44-4]; Down 200; 13.2uM; PC3; HT_HG-U133A	UGT8 DDX17 RNGTT MINK1 HAPLN1	4.66e-05	192	47	5	6752_DN
Drug	fluphenazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	NSD1 BRIP1 ARHGAP35 GLCE HEXIM1	5.14e-05	196	47	5	6954_DN
Drug	Viomycin sulfate [37883-00-4]; Down 200; 5.2uM; PC3; HT_HG-U133A	NSD1 TNFRSF10B ARHGAP35 MINK1 HAPLN1	5.14e-05	196	47	5	7278_DN
Drug	alpha-estradiol; Down 200; 0.01uM; HL60; HT_HG-U133A	ITPKC TNFRSF10B RNGTT ARHGAP35 GLCE	5.26e-05	197	47	5	6169_DN
Drug	candoxin	DNAJB6 DDX17 GALNT2 MINK1	5.62e-05	101	47	4	ctd:C459604
Drug	Potassium Chloride	SLC12A1 SLC12A2	6.22e-05	6	47	2	DB00761
Disease	Muscular dystrophy, limb-girdle, autosomal dominant	DNAJB6 MYH6	1.11e-04	10	47	2	cv:C5675009
Disease	epilepsy (implicated_via_orthology)	SLC12A1 SLC12A2 MAP4K4 MINK1	1.33e-04	163	47	4	DOID:1826 (implicated_via_orthology)
Disease	Limb Deformities, Congenital	GPC6 HAPLN1	3.33e-04	17	47	2	C0206762
Disease	depressive symptom measurement	PHF2 GALNT2 GPC6 HEXIM1 PROX2	5.71e-04	426	47	5	EFO_0007006
Disease	Limb-girdle muscular dystrophy	DNAJB6 MYH6	7.88e-04	26	47	2	cv:C0686353
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	CMIP GALNT2 MINK1	1.10e-03	127	47	3	EFO_0008595, EFO_0020947
Disease	very low density lipoprotein particle size measurement	CMIP TNFRSF10B GALNT2	1.26e-03	133	47	3	EFO_0008594
Disease	triglyceride measurement, phospholipid measurement	CMIP TNFRSF10B GALNT2	1.64e-03	146	47	3	EFO_0004530, EFO_0004639
Disease	cholesteryl esters to total lipids in IDL percentage	CMIP GALNT2	2.90e-03	50	47	2	EFO_0022247
Disease	aspartate aminotransferase measurement	NSD1 BRIP1 TNFRSF10B ARHGAP35 GALNT2 GCN1	2.99e-03	904	47	6	EFO_0004736

Protein segments in the cluster

Peptide	Gene	Start	Entry
YISLDKKKALWFPAL	ARID4B	181	Q4LE39
KLPSYRAAKKLWKVC	EPB41	466	P11171
WKGYLVRSLLRSKKK	IQCD	411	Q96DY2
KIYKYKKVLSNPSRW	CMIP	161	Q8IY22
PVFKEFVKRWKSYLK	GLCE	596	O94923
KSWKKRYFLLRASGI	RAPH1	411	Q70E73
KKRLRKPSKWLLEYT	NSD1	1271	Q96L73
SKPWKKLKTVLKYSP	ITPKC	386	Q96DU7
WYLKPKLGKKLRSDE	FAM47C	941	Q5HY64
PRLKSKKWSKKFFSF	MAP4K4	251	O95819
IKLLDLKPYKVSWKA	RNGTT	281	O60942
ELRKKLSCKPFKWYL	GALNT2	416	Q10471
RPSKKKRHWKPYYKL	HEXIM1	156	O94992
FKWELTKYPELDKLK	DNAH12	666	Q6ZR08
VPKKLTEWFKKAFSL	GCN1	421	Q92616
YLIKFWAKLSAKKTP	LRGUK	646	Q96M69
PSYKLLEKLKERWLS	BRIP1	696	Q9BX63
WKKPIYKIISKLDSD	PROX2	566	Q3B8N5
LLEVCKKKKRWYLVF	CDKL2	66	Q92772
PEDIKKAYRKLALKW	DNAJB6	16	O75190
FFWPKITRLDFKKNK	EPB41L5	266	Q9HCM4
KLKLSKKVWSALPYT	GPC6	391	Q9Y625
KELLLTSPKYRFWKK	DCLRE1C	66	Q96SD1
RELRKKLKCKSFKWY	GALNT5	781	Q7Z7M9
LLSWVTKFIYRKIKS	UGT8	491	Q16880
KLTVKFWRALLSKAY	HEATR1	1571	Q9H583
RLRKKKWDLSELPKF	DDX17	116	Q92841
ILDPEKIKKKYLRTW	HCN2	276	Q9UL51
WLSFLKHKLPLSLYK	NOC4L	256	Q9BVI4
LSSRKWKEYIAKKPK	MTBP	371	Q96DY7
HYWKKVLPLLKIIKK	RGPD1	596	P0DJD0
KIRIKWTKLTSDYLK	HAPLN1	76	P10915
PRLKSKKWSKKFIDF	MINK1	251	Q8N4C8
KYERISWSFKEKKPL	RPP40	161	O75818
LDSIYKKTLPDWKRS	SMCHD1	1776	A6NHR9
AKWKYKNSKPDSLLK	PHF2	601	O75151
LPKFSQLKWKALYSD	SCPEP1	391	Q9HB40
IPYILTLRKKWKDCK	SLC12A1	926	Q13621
SLKDWFAKRKKFKRP	SUPT5H	321	O00267
WMKLYFKIKPLLKSA	MYH6	831	P13533
AKKLLETKPEFLKWF	ARHGAP35	366	Q9NRY4
AAKLYKKERWLSLPS	RINT1	621	Q6NUQ1
TLLIPYLLTTKKKWK	SLC12A2	1036	P55011
RPSYWKFLLRLTKGK	TMEM135	401	Q86UB9
LSWSKKRYEAKLKKL	MTERF1	381	Q99551
VCKSLLWKKVLPYLK	TNFRSF10B	231	O14763
DVYKLPKETWLKKLE	WDR93	221	Q6P2C0
KSLFYLLLKLKKWIS	TRPC6	771	Q9Y210