Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 MATN3 ADGRV1 RET ITPR2 ITPR3 CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	2.53e-08	749	110	19	GO:0005509
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACA ACACB	3.01e-05	2	110	2	GO:0003989
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR2 ITPR3	8.99e-05	3	110	2	GO:0005220
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACA ACACB	4.45e-04	6	110	2	GO:0016421
GeneOntologyMolecularFunction	dihydropyrimidinase activity	DPYS DPYSL2	4.45e-04	6	110	2	GO:0004157
GeneOntologyMolecularFunction	biotin binding	ACACA ACACB	4.45e-04	6	110	2	GO:0009374
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA ACACB	6.20e-04	7	110	2	GO:0016885
GeneOntologyMolecularFunction	manganese ion binding	LARGE2 GALNT2 PPM1N GALNT4	6.38e-04	71	110	4	GO:0030145
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 RET CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	5.47e-14	187	108	15	GO:0007156
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 RET CELSR2 ELFN1 DCHS1 CDH1 CDH6 PCDHGA8	7.81e-12	313	108	16	GO:0098742
GeneOntologyBiologicalProcess	condensed mesenchymal cell proliferation	DCHS2 FAT4 DCHS1	5.56e-07	4	108	3	GO:0072137
GeneOntologyBiologicalProcess	cell-cell adhesion	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 ICAM3 RPSA ADGRV1 RET CELSR2 ELFN1 DCHS1 CDH1 CDH6 PCDHGA8 IL23R	6.98e-07	1077	108	20	GO:0098609
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACA ACACB	2.72e-05	2	108	2	GO:2001295
GeneOntologyBiologicalProcess	positive regulation of protein kinase A signaling	ADGRV1 APP AKAP12	4.87e-05	14	108	3	GO:0010739
Domain	Cadherin	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 RET CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	1.72e-16	113	111	15	PF00028
Domain	CADHERIN_2	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 RET CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	1.97e-16	114	111	15	PS50268
Domain	-	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 RET CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	1.97e-16	114	111	15	2.60.40.60
Domain	CA	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 RET CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	2.25e-16	115	111	15	SM00112
Domain	Cadherin-like	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 RET CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	2.57e-16	116	111	15	IPR015919
Domain	Cadherin	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 RET CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	3.35e-16	118	111	15	IPR002126
Domain	Cadherin_CS	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	2.96e-15	109	111	14	IPR020894
Domain	CADHERIN_1	DCHS2 FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 CELSR2 DCHS1 CDH1 CDH6 PCDHGA8	4.96e-15	113	111	14	PS00232
Domain	Cadherin_tail	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	4.03e-11	37	111	8	PF15974
Domain	Cadherin_CBD	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	4.03e-11	37	111	8	IPR031904
Domain	Cadherin_C	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	1.20e-10	42	111	8	IPR032455
Domain	Cadherin_C_2	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	1.20e-10	42	111	8	PF16492
Domain	Cadherin_2	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	4.59e-09	65	111	8	PF08266
Domain	Cadherin_N	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	4.59e-09	65	111	8	IPR013164
Domain	AcCoA_COase_cen	ACACA ACACB	3.50e-05	2	111	2	IPR013537
Domain	ACC_central	ACACA ACACB	3.50e-05	2	111	2	PF08326
Domain	InsP3_rcpt-bd	ITPR2 ITPR3	1.05e-04	3	111	2	IPR000493
Domain	Zfx_Zfy_act	ZFY ZNF711	1.05e-04	3	111	2	PF04704
Domain	Transcrp_activ_Zfx/Zfy-dom	ZFY ZNF711	1.05e-04	3	111	2	IPR006794
Domain	COA_CT_N	ACACA ACACB	2.08e-04	4	111	2	IPR011762
Domain	COA_CT_C	ACACA ACACB	2.08e-04	4	111	2	IPR011763
Domain	Carboxyl_trans	ACACA ACACB	2.08e-04	4	111	2	PF01039
Domain	COA_CT_CTER	ACACA ACACB	2.08e-04	4	111	2	PS50989
Domain	Carboxyl_trans	ACACA ACACB	2.08e-04	4	111	2	IPR000022
Domain	COA_CT_NTER	ACACA ACACB	2.08e-04	4	111	2	PS50980
Domain	Biotin_BS	ACACA ACACB	3.46e-04	5	111	2	IPR001882
Domain	Biotin_carb_C	ACACA ACACB	3.46e-04	5	111	2	SM00878
Domain	Biotin_carb_C	ACACA ACACB	3.46e-04	5	111	2	PF02785
Domain	Biotin_carboxylation_dom	ACACA ACACB	3.46e-04	5	111	2	IPR011764
Domain	CPSASE_1	ACACA ACACB	3.46e-04	5	111	2	PS00866
Domain	Biotin_COase_C	ACACA ACACB	3.46e-04	5	111	2	IPR005482
Domain	BIOTIN	ACACA ACACB	3.46e-04	5	111	2	PS00188
Domain	BC	ACACA ACACB	3.46e-04	5	111	2	PS50979
Domain	RIH_assoc	ITPR2 ITPR3	5.17e-04	6	111	2	PF08454
Domain	RIH_assoc-dom	ITPR2 ITPR3	5.17e-04	6	111	2	IPR013662
Domain	RIH_dom	ITPR2 ITPR3	5.17e-04	6	111	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR2 ITPR3	5.17e-04	6	111	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR2 ITPR3	5.17e-04	6	111	2	IPR015925
Domain	Hydantoinase/dihydroPyrase	DPYS DPYSL2	5.17e-04	6	111	2	IPR011778
Domain	CPSASE_2	ACACA ACACB	5.17e-04	6	111	2	PS00867
Domain	-	ITPR2 ITPR3	5.17e-04	6	111	2	1.25.10.30
Domain	RYDR_ITPR	ITPR2 ITPR3	5.17e-04	6	111	2	PF01365
Domain	Ins145_P3_rec	ITPR2 ITPR3	5.17e-04	6	111	2	PF08709
Domain	Rudment_hybrid_motif	ACACA ACACB	5.17e-04	6	111	2	IPR011054
Domain	CPSase_L_D2	ACACA ACACB	7.21e-04	7	111	2	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA ACACB	7.21e-04	7	111	2	IPR005479
Domain	BC-like_N	ACACA ACACB	7.21e-04	7	111	2	IPR005481
Domain	Biotin_carb_N	ACACA ACACB	7.21e-04	7	111	2	PF00289
Domain	-	DPYS DPYSL2	9.57e-04	8	111	2	2.30.40.10
Domain	Biotin_lipoyl	ACACA ACACB	1.23e-03	9	111	2	PF00364
Domain	MIR	ITPR2 ITPR3	1.53e-03	10	111	2	PS50919
Domain	MIR	ITPR2 ITPR3	1.53e-03	10	111	2	PF02815
Domain	MIR	ITPR2 ITPR3	1.53e-03	10	111	2	SM00472
Domain	MIR_motif	ITPR2 ITPR3	1.53e-03	10	111	2	IPR016093
Domain	Amidohydro_1	DPYS DPYSL2	1.53e-03	10	111	2	PF01979
Domain	Biotin_lipoyl	ACACA ACACB	1.53e-03	10	111	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACA ACACB	1.53e-03	10	111	2	PS50968
Domain	Metal-dep_hydrolase_composite	DPYS DPYSL2	1.53e-03	10	111	2	IPR011059
Domain	Amidohydro-rel	DPYS DPYSL2	1.86e-03	11	111	2	IPR006680
Domain	Single_hybrid_motif	ACACA ACACB	2.22e-03	12	111	2	IPR011053
Domain	-	ACACA ACACB	2.62e-03	13	111	2	3.40.50.20
Domain	PROTEIN_KINASE_TYR	LMTK2 RET TXK MUSK	2.68e-03	97	111	4	PS00109
Domain	Tyr_kinase_AS	LMTK2 RET TXK MUSK	2.68e-03	97	111	4	IPR008266
Domain	ATP-grasp	ACACA ACACB	3.04e-03	14	111	2	IPR011761
Domain	PreATP-grasp_dom	ACACA ACACB	3.04e-03	14	111	2	IPR016185
Domain	ATP_GRASP	ACACA ACACB	3.04e-03	14	111	2	PS50975
Domain	-	ACACA ACACB	3.49e-03	15	111	2	3.30.1490.20
Domain	ATP_grasp_subdomain_1	ACACA ACACB	5.03e-03	18	111	2	IPR013815
Domain	-	ACACA ACACB	5.03e-03	18	111	2	3.30.470.20
Domain	PP2C	PHLPP1 PPM1N	5.60e-03	19	111	2	PF00481
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	FN1 MATN3 ICAM3 COL6A5 LAMC3 APP MFAP5 PXDN CDH1 MUSK	5.75e-06	300	78	10	M610
Pathway	REACTOME_ECM_PROTEOGLYCANS	FN1 MATN3 COL6A5 APP MUSK	6.19e-05	76	78	5	M27219
Pathway	REACTOME_ECM_PROTEOGLYCANS	FN1 MATN3 COL6A5 APP	1.29e-04	47	78	4	MM14925
Pathway	WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION	FN1 CDH1 CDH6	1.48e-04	19	78	3	M39370
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	APP ITPR2 ITPR3	2.02e-04	21	78	3	M47689
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	APP ITPR2 ITPR3	2.33e-04	22	78	3	M47690
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR2 ITPR3	2.99e-04	5	78	2	M49000
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 CELSR2 PCDHGA8	1.78e-12	72	111	9	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 CDH1 PCDHGA8	2.29e-12	74	111	9	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 CELSR2 PCDHGA8	3.32e-12	77	111	9	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 CELSR2 PCDHGA8	4.74e-12	80	111	9	10716726
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	5.25e-11	68	111	8	11230163
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	8.85e-10	15	111	5	23515096
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	ADGRV1 RET APP ITPR2 ITPR3 GPR61 MUSK IL23R	1.32e-09	101	111	8	23382219
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SMG1 DDX59 ABCF1 ACACA USP11 NUP88 LMTK2 ITPR2 ITPR3 MPHOSPH10 CDH1 EIF2AK3	1.85e-08	440	111	12	34244565
Pubmed	Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.	DCHS2 FAT4 RET DCHS1 CDH1	1.89e-08	26	111	5	21303848
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	2.80e-08	28	111	5	15347688
Pubmed	Functional significance of isoform diversification in the protocadherin gamma gene cluster.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	7.81e-08	34	111	5	22884324
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRFN1 ACACA LAD1 ZNF316 LMTK2 LAMC3 RPSA BTAF1 CEP192 ITPR2 ITPR3 INTS5 SLC38A10 CELSR2 KANK3 TNFAIP2 AHNAK2	8.34e-08	1105	111	17	35748872
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SMG1 ACACB PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 SPG11 DBN1 PRPF8 PRX PXDN PES1 BOD1L1 MPHOSPH10 CDH1 PCDHGA8	1.49e-07	1442	111	19	35575683
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DPYSL2 ABCF1 ACACA FN1 USP11 NUP88 RPSA PRPF8 ITPR3 PES1 GEMIN4 MPHOSPH10 DDX24	1.79e-07	653	111	13	22586326
Pubmed	A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	2.97e-07	44	111	5	19029045
Pubmed	Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching.	FAT4 RET DCHS1 CDH1	4.58e-07	20	111	4	26116666
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DCHS2 ABCF1 ACACA FN1 ACACB MATN3 SPG11 MEI1 PRPF8 KIF19 DDX24	5.95e-07	497	111	11	36774506
Pubmed	Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.	DCHS2 FAT4 DCHS1 CDH1	9.94e-07	24	111	4	26116661
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT4 DCHS1	1.10e-06	7	111	3	16059920
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA4 PCDHGA3	1.11e-06	57	111	5	32633719
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	DPYSL2 ABCF1 ACACA ACACB NUP88 RPSA BTAF1 DBN1 PRPF8 AKAP12 R3HCC1L PES1 BOD1L1 AHNAK2	1.73e-06	934	111	14	33916271
Pubmed	Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.	FAT4 FN1 DCHS1	2.62e-06	9	111	3	28705793
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DPYSL2 FAT4 ACACA FN1 ZNF316 PRPF8 PRDM2 ITPR2 SLC38A10 R3HCC1L BOD1L1 RPE65	4.30e-06	736	111	12	29676528
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	PRPSAP1 ACACA ACACB LAD1 DBN1 AKAP12 ITPR2 ITPR3 MPHOSPH10 CDH1	5.12e-06	503	111	10	36217030
Pubmed	Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.	FAT4 DCHS1 CDH1	5.12e-06	11	111	3	26114487
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	PRPSAP1 PNKP ACACA USP11 NUP88 AKAP12 DDX24	5.62e-06	212	111	7	33462405
Pubmed	Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin.	MYD88 FN1 LAMC3 CDH1	6.67e-06	38	111	4	27653694
Pubmed	Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney.	FAT4 RET AKAP12 CDH1	6.67e-06	38	111	4	32715478
Pubmed	Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.	ITPR2 ITPR3	1.01e-05	2	111	2	9065779
Pubmed	Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes.	FAT4 CDH6	1.01e-05	2	111	2	30405348
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACA ACACB	1.01e-05	2	111	2	24944901
Pubmed	Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias.	DPYSL2 APP	1.01e-05	2	111	2	27609071
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACA ACACB	1.01e-05	2	111	2	20139635
Pubmed	Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	1.01e-05	2	111	2	8081734
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACA ACACB	1.01e-05	2	111	2	28081256
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACA ACACB	1.01e-05	2	111	2	26976583
Pubmed	A novel type of myosin encoded by the mouse deafness gene shaker-2.	LLGL1 MYO15A	1.01e-05	2	111	2	9703981
Pubmed	Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.	ITPR2 ITPR3	1.01e-05	2	111	2	15632133
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACA ACACB	1.01e-05	2	111	2	25001074
Pubmed	Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease.	DBN1 APP	1.01e-05	2	111	2	17251419
Pubmed	Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.	HEXB APP	1.01e-05	2	111	2	22496568
Pubmed	Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.	FAT4 DCHS1	1.01e-05	2	111	2	25355906
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACA ACACB	1.01e-05	2	111	2	10677481
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACA ACACB	1.01e-05	2	111	2	24338821
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACA ACACB	1.01e-05	2	111	2	25282359
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACA ACACB	1.01e-05	2	111	2	27693630
Pubmed	Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.	ITPR2 ITPR3	1.01e-05	2	111	2	17496801
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACA ACACB	1.01e-05	2	111	2	32215608
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACA ACACB	1.01e-05	2	111	2	29772612
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACA ACACB	1.01e-05	2	111	2	29976587
Pubmed	Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.	ITPR2 ITPR3	1.01e-05	2	111	2	24901844
Pubmed	Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.	ITPR2 ITPR3	1.01e-05	2	111	2	33854148
Pubmed	PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing.	FN1 PRPF8	1.01e-05	2	111	2	36609600
Pubmed	Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.	ITPR2 ITPR3	1.01e-05	2	111	2	19528657
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACA ACACB	1.01e-05	2	111	2	15749055
Pubmed	Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.	ITPR2 ITPR3	1.01e-05	2	111	2	8063813
Pubmed	Identification of new human cadherin genes using a combination of protein motif search and gene finding methods.	DCHS2 FAT4	1.01e-05	2	111	2	15003449
Pubmed	Activation of PERK signaling attenuates Abeta-mediated ER stress.	APP EIF2AK3	1.01e-05	2	111	2	20463975
Pubmed	IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.	ITPR2 ITPR3	1.01e-05	2	111	2	16195467
Pubmed	HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.	RET HOOK3	1.01e-05	2	111	2	17639057
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACA ACACB	1.01e-05	2	111	2	29433631
Pubmed	Structure of the planar cell polarity cadherins Fat4 and Dachsous1.	FAT4 DCHS1	1.01e-05	2	111	2	36797229
Pubmed	Calcium regulates the interaction of amyloid precursor protein with Homer3 protein.	APP HOMER3	1.01e-05	2	111	2	24792907
Pubmed	Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.	ITPR2 ITPR3	1.01e-05	2	111	2	15713744
Pubmed	Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture.	FAT4 DCHS1	1.01e-05	2	111	2	25930014
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACA ACACB	1.01e-05	2	111	2	36076520
Pubmed	Ectopic expression of RET results in microphthalmia and tumors in the retinal pigment epithelium.	RET RPE65	1.01e-05	2	111	2	9935163
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACA ACACB	1.01e-05	2	111	2	28290443
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACA ACACB	1.01e-05	2	111	2	30244972
Pubmed	Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases.	LLGL1 CDH1	1.01e-05	2	111	2	31058107
Pubmed	NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.	HECW1 RET CDH1	1.12e-05	14	111	3	27119228
Pubmed	Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.	FN1 RET CDH1	1.40e-05	15	111	3	23064016
Pubmed	Non-muscle myosin II deletion in the developing kidney causes ureter-bladder misconnection and apical extrusion of the nephric duct lineage epithelia.	FN1 RET CDH1	1.40e-05	15	111	3	28478097
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ABCF1 PDPR USP11 SPG11 CEP192 APP PRPF8 AKAP12 ITPR2 ITPR3 R3HCC1L LLGL1 PES1 CCDC97 DDX24 EIF2AK3	2.03e-05	1487	111	16	33957083
Pubmed	Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.	DCHS2 FAT4 DCHS1	2.49e-05	18	111	3	33108146
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	APP PRPF8 ITPR3 PXDN TNFAIP2 CDH1 EIF2AK3 GALNT4	2.64e-05	371	111	8	15747579
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	HEXB LARGE2 DPYSL2 FAT4 ABCF1 GALNT2 LAMC3 APP ITPR2 PXDN CELSR2 PES1 EIF2AK3 GALNT4	2.96e-05	1201	111	14	35696571
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR2 ITPR3	3.02e-05	3	111	2	10874040
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACA ACACB	3.02e-05	3	111	2	34668531
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR2 ITPR3	3.02e-05	3	111	2	20395455
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACA ACACB	3.02e-05	3	111	2	30018077
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR2 ITPR3	3.02e-05	3	111	2	17437169
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR2 ITPR3	3.02e-05	3	111	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR2 ITPR3	3.02e-05	3	111	2	36350267
Pubmed	The versatility and universality of calcium signalling.	ITPR2 ITPR3	3.02e-05	3	111	2	11413485
Pubmed	Pharmacophore-based screening targeted at upregulated FN1, MMP-9, APP reveals therapeutic compounds for nasopharyngeal carcinoma.	FN1 APP	3.02e-05	3	111	2	26773938
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	3.02e-05	3	111	2	26009177
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACA ACACB	3.02e-05	3	111	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACA ACACB	3.02e-05	3	111	2	18031993
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR2 ITPR3	3.02e-05	3	111	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR2 ITPR3	3.02e-05	3	111	2	23955339
Pubmed	Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.	ZFY ZNF711	3.02e-05	3	111	2	32406922
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR2 ITPR3	3.02e-05	3	111	2	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR2 ITPR3	3.02e-05	3	111	2	24904548
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACA ACACB	3.02e-05	3	111	2	20457939
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACA ACACB	3.02e-05	3	111	2	36417534
Pubmed	Self-regulated alternative splicing at the AHNAK locus.	PRX AHNAK2	3.02e-05	3	111	2	21940993
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA ACACB	3.02e-05	3	111	2	18455495
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR2 ITPR3	3.02e-05	3	111	2	9858485
Pubmed	E-cadherin, fibronectin and Slug immunoexpression in non-melanoma skin cancers.	FN1 CDH1	3.02e-05	3	111	2	35263398
Interaction	PCDHGA4 interactions	LRFN1 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 EIF2AK3 PCDHGA8	1.06e-11	34	111	8	int:PCDHGA4
Interaction	PCDHGA6 interactions	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 DCHS1	1.81e-07	24	111	5	int:PCDHGA6
Interaction	PCDHGA7 interactions	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 DCHS1	2.25e-07	25	111	5	int:PCDHGA7
Interaction	PCDHGA8 interactions	PCDHGA5 PCDHGA4 PCDHGA8	1.61e-06	5	111	3	int:PCDHGA8
Interaction	SIRT6 interactions	SMG1 FAT4 DDX59 ABCF1 ACACA USP11 NUP88 LMTK2 PRPF8 ITPR2 ITPR3 CELSR2 MPHOSPH10 CDH1 EIF2AK3	1.84e-06	628	111	15	int:SIRT6
Interaction	DCANP1 interactions	FAT4 PCDHGA11 CELSR2 DCHS1	3.17e-06	19	111	4	int:DCANP1
Interaction	LOC254896 interactions	FAT4 ADGRV1 APP CELSR2 DCHS1	3.77e-06	43	111	5	int:LOC254896
Interaction	PCDHGB1 interactions	FAT4 LRFN1 PCDHGA11 PCDHGA7 CELSR2 DCHS1	4.20e-06	77	111	6	int:PCDHGB1
Interaction	RPL23 interactions	FAT4 FN1 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 RPSA APP PRPF8 CELSR2 PES1 GEMIN4 DDX24	8.68e-06	540	111	13	int:RPL23
Interaction	IFNE interactions	LARGE2 FAT4 ACACB ADGRV1	1.39e-05	27	111	4	int:IFNE
Interaction	H2BC5 interactions	ABCF1 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PRPF8 PCDHGA8	1.48e-05	331	111	10	int:H2BC5
Interaction	DUSP26 interactions	USP11 RET PRPF8 ITPR3 GEMIN4	1.83e-05	59	111	5	int:DUSP26
Interaction	PCDHGA12 interactions	PCDHGA7 PCDHGA4 APP	1.90e-05	10	111	3	int:PCDHGA12
Interaction	PCDHGA5 interactions	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA8	2.52e-05	63	111	5	int:PCDHGA5
Interaction	PCDHA9 interactions	LRFN1 PCDHGA11 PCDHGA6 PCDHGA4	2.78e-05	32	111	4	int:PCDHA9
Interaction	PCDHGA9 interactions	PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA8	3.15e-05	33	111	4	int:PCDHGA9
Interaction	DKKL1 interactions	LARGE2 FAT4 PDPR PCDHGA11 ADGRV1 CELSR2	3.45e-05	111	111	6	int:DKKL1
Interaction	FBXO22 interactions	DCHS2 ABCF1 ACACA FN1 ACACB MATN3 SPG11 MEI1 PRPF8 KIF19 PHLPP1 DDX24	4.30e-05	540	111	12	int:FBXO22
Interaction	DOK2 interactions	PRPSAP1 DBN1 RET AKAP12 TXK SPIN1	4.42e-05	116	111	6	int:DOK2
Interaction	SIRT7 interactions	DPYSL2 ABCF1 ACACA FN1 USP11 NUP88 RPSA APP PRPF8 ITPR3 PES1 GEMIN4 MPHOSPH10 DDX24	5.92e-05	744	111	14	int:SIRT7
Interaction	ZNF35 interactions	MYD88 APP GEMIN4 HOMER3	7.54e-05	41	111	4	int:ZNF35
Interaction	XAGE1A interactions	FAT4 ADGRV1 CELSR2 DCHS1	7.54e-05	41	111	4	int:XAGE1A
Interaction	PSG8 interactions	FAT4 PDPR ADGRV1 CELSR2	7.54e-05	41	111	4	int:PSG8
Interaction	NUP210P1 interactions	FAT4 PCDHGA11 CELSR2 DCHS1	8.30e-05	42	111	4	int:NUP210P1
Interaction	LIMA1 interactions	LRFN1 USP11 RPSA DBN1 APP PRPF8 ITPR3 PHLPP1 DDX24 CDH1	1.31e-04	429	111	10	int:LIMA1
Interaction	NUP43 interactions	ACACA ACACB ZNF316 NUP88 PRDM2 ZNF711 NFATC2IP BOD1L1 MPHOSPH10 HSF2 DDX24 AHNAK2	1.71e-04	625	111	12	int:NUP43
Interaction	DCHS1 interactions	PCDHGA7 PCDHGA6 DCHS1	1.73e-04	20	111	3	int:DCHS1
Interaction	C1orf116 interactions	APP CDH1 HOMER3	1.73e-04	20	111	3	int:C1orf116
Interaction	RYK interactions	FAT4 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 CELSR2 DCHS1	1.74e-04	212	111	7	int:RYK
Interaction	HSP90AA1 interactions	SMG1 DDX59 ZBTB17 FN1 USP11 RPSA SPG11 RET APP PRPF8 LLGL1 BOD1L1 DMPK DDX24 CDH1 EIF2AK3 MUSK RNF111	1.80e-04	1263	111	18	int:HSP90AA1
Interaction	RNMT interactions	HEXB DPYSL2 ADGRV1 APP NFATC2IP	1.81e-04	95	111	5	int:RNMT
Cytoband	5q31	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	4.31e-10	115	111	8	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	7.10e-07	298	111	8	chr5q31
Cytoband	5q13	HEXB ADGRV1 BHMT2	2.05e-05	22	111	3	5q13
GeneFamily	Clustered protocadherins	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	1.76e-10	64	73	8	20
GeneFamily	Cadherin related	DCHS2 FAT4 RET DCHS1	5.59e-07	17	73	4	24
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR2 ITPR3	4.81e-05	3	73	2	297
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	LMTK2 RET MUSK	5.60e-04	40	73	3	321
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	LMTK2 CEP192 ITPR3 ELFN1 MPHOSPH10	8.24e-04	181	73	5	694
GeneFamily	Protein phosphatases, Mg2+/Mn2+ dependent	PHLPP1 PPM1N	2.10e-03	17	73	2	701
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT2 GALNT4	2.91e-03	20	73	2	433
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 PCDHGA11 BTAF1 AKAP12 TXK NFATC2IP ELFN1 DDX24	3.00e-08	193	111	8	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 PCDHGA11 BTAF1 AKAP12 TXK ELFN1 DDX24	6.41e-07	197	111	7	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PCDHGA5 ADGRV1 RET PHLPP1 MGARP EIF2AK3	1.66e-06	144	111	6	3ba7f8bd6d1c551048403c94693d63e60f7cbbb7
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PCDHGA5 ADGRV1 RET PHLPP1 MGARP EIF2AK3	1.66e-06	144	111	6	38ff324366ad5be626e3657c1e33277fc36ddd4c
ToppCell	mild_COVID-19_(asymptomatic)-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	LRFN1 PCDHGA5 TXK CELSR2 DCHS1 HSF2	2.28e-06	152	111	6	f944743f40ff6ed3a7a096dd53e12d3526c67c4d
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DCHS2 FN1 PCDHGA5 AKAP12 DCHS1 UNC80	3.79e-06	166	111	6	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	NS-moderate-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT4 FN1 LAMC3 AKAP12 ELFN1 DCHS1	5.13e-06	175	111	6	f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGA6 ZNF316 LAMC3 CELSR2 TNFAIP2 DMPK	5.30e-06	176	111	6	5e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DCHS2 MATN3 DBN1 AKAP12 KANK3 HOMER3	5.48e-06	177	111	6	dfaed388926ce050730492a532824af68bf4feff
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAT4 PCDHGA6 PCDHGA3 RET MORC4 DMPK	6.63e-06	183	111	6	351d575339038bd4a66f408da518c567444208e8
ToppCell	343B-Fibroblasts-Fibroblast-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CEP192 DBN1 AKAP12 MFAP5 BHMT2 AHNAK2	7.27e-06	186	111	6	1bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell	343B-Fibroblasts-Fibroblast-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	CEP192 DBN1 AKAP12 MFAP5 BHMT2 AHNAK2	7.27e-06	186	111	6	59db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DCHS2 APP PRX PXDN KANK3 PHLPP1	8.21e-06	190	111	6	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	LAM-Endothelial-LymEndo\|LAM / Condition, Lineage and Cell class	DBN1 RET APP AKAP12 PXDN KANK3	8.98e-06	193	111	6	68eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCell	cellseq-Endothelial-Endothelial_Lymphatic-LEC-LEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DBN1 APP AKAP12 KANK3 BHMT2 HOMER3	9.52e-06	195	111	6	8321531bb976e5005973b82f32177be88113abb3
ToppCell	ASK428-Mesenchymal\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	FN1 COL6A5 LAMC3 AKAP12 MFAP5 CDH6	9.52e-06	195	111	6	2b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCell	cellseq-Endothelial-Endothelial_Lymphatic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DBN1 APP AKAP12 KANK3 BHMT2 HOMER3	9.52e-06	195	111	6	d8f01746c8f92532bd1a5c1b0bbb86208d64c3cd
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT4 FN1 MFAP5 RPE65 CDH6 AHNAK2	9.52e-06	195	111	6	eb2003d4f15cad213d17eda8ab7479f5a0c62164
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT4 FN1 MFAP5 RPE65 CDH6 AHNAK2	9.52e-06	195	111	6	44f67437ea65d530133a0240b17f9860d9cc0e99
ToppCell	cellseq-Endothelial-Endothelial_Lymphatic-LEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DBN1 APP AKAP12 KANK3 BHMT2 HOMER3	9.52e-06	195	111	6	918b68a271a81202778714e10b09c5c724575b73
ToppCell	ASK428-Mesenchymal-Fibroblast\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	FN1 COL6A5 LAMC3 AKAP12 MFAP5 CDH6	9.52e-06	195	111	6	c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCell	distal-Endothelial-Lymphatic\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DBN1 APP AKAP12 KANK3 BHMT2 HOMER3	9.80e-06	196	111	6	3e8a20e1d163dcbd3bbd99fe179d54af02298af0
ToppCell	distal-3-Endothelial-Lymphatic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DBN1 APP AKAP12 KANK3 BHMT2 HOMER3	1.01e-05	197	111	6	9ea0e2ed9c3f97591a06e70570640996580417d5
ToppCell	distal-Endothelial-Lymphatic-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DBN1 APP AKAP12 KANK3 BHMT2 HOMER3	1.01e-05	197	111	6	8f2e19409ebe9a490d5a245fa82c765ed6d77c3e
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Fibroblasts-4\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FN1 COL6A5 LAMC3 AKAP12 MFAP5 MUSK	1.10e-05	200	111	6	54b18c92daaa3b3368c0c46134b0c27e10c8dbb0
ToppCell	Biopsy_IPF-Epithelial-KRT5-/KRT17+\|Biopsy_IPF / Sample group, Lineage and Cell type	LAD1 DBN1 ITPR3 PXDN CDH1 CDH6	1.10e-05	200	111	6	2fc7a3b3aea711ad3d96fd9513f4b40533056d86
ToppCell	COVID-19_Severe-CD8+_T_naive\|World / disease group, cell group and cell class	LAMC3 ADGRV1 DBN1 RFX4 TXK	4.21e-05	154	111	5	b568417d88a78d8c46688847f0f5f4989bd36387
ToppCell	mild_COVID-19_(asymptomatic)-CD8+_T_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	LRFN1 PCDHGA5 TXK CELSR2 DCHS1	4.34e-05	155	111	5	e2c901d5c9e42d25d7702e5e8fc19b06f7c817be
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MATN3 LAD1 ADGRV1 PRX TXK	4.34e-05	155	111	5	c58a5fb8d853f12204e961d633e83452eb12a659
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MATN3 LAD1 ADGRV1 PRX TXK	4.34e-05	155	111	5	9cb8c42c2e451b2d4dcd7154a4b1bfd21bbb7ea8
ToppCell	droplet-Fat-Scat-21m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 COL6A5 MFAP5 PXDN CDH1	5.85e-05	165	111	5	3f0c2486ea357d10dad0b703cf75cc29bdd5b5cf
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA FN1 ACACB ACAT2 BHMT2	5.85e-05	165	111	5	d449a568664a81d9b5538e8f409301448a32ac37
ToppCell	-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	PCDHGA3 ICAM3 MEI1 MFAP5 MUSK	6.02e-05	166	111	5	bc9323de1373fdc0357e6bb46874f6c4787443a9
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMC3 AKAP12 MFAP5 ZNF469 AHNAK2	6.55e-05	169	111	5	031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell	COVID-19_Mild-Neu_2\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	NUP88 ZFY TXK SPIN1 EIF2AK3	7.12e-05	172	111	5	f5fd08b42c002d4693646b27e7b708eceb49524f
ToppCell	ASK440-Epithelial-Transformed_epithelium\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	LARGE2 MATN3 COL6A5 CELSR2 DCHS1	7.12e-05	172	111	5	df3800bcd9777d02900eba0cfc26ab73de8a1d95
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PCDHGA7 PCDHGA3 LAD1 ZNF469	7.61e-05	90	111	4	3817a5b0235e632d976ea565175bdbebbd959bf0
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PCDHGA7 PCDHGA3 LAD1 ZNF469	7.61e-05	90	111	4	a528f5dcee1a356dea89ff2588d2e0f276f2d5fc
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DBN1 RET AKAP12 PXDN KANK3	7.93e-05	176	111	5	5d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGA6 ZNF316 LAMC3 TNFAIP2 DMPK	8.15e-05	177	111	5	14fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL2 FN1 AKAP12 KANK3 DCHS1	8.37e-05	178	111	5	375156ba1c7b8592bf733c75f24968161f7cfa09
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	CEP192 TRUB2 ITPR3 DCHS1 GEMIN4	8.59e-05	179	111	5	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	10x3'2.3-week_12-13-Myeloid_macrophage-stroma-erythroid_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PRX MFAP5 ZNF469 CELSR2 CDH6	8.59e-05	179	111	5	c17ae394b855f01f8ca1765c416fd8b34a96e60b
ToppCell	droplet-Limb_Muscle-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB DPYSL2 RPSA MFAP5 TNFAIP2	8.59e-05	179	111	5	013818e173101efca7625ccd4258e60655815d73
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAT2 ATCAY ITPR2 INTS5 KIF19	9.05e-05	181	111	5	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAT2 ATCAY ITPR2 INTS5 KIF19	9.05e-05	181	111	5	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAT2 ATCAY ITPR2 INTS5 KIF19	9.05e-05	181	111	5	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APP AKAP12 KANK3 BHMT2 HOMER3	9.53e-05	183	111	5	2d0d3b486498a7903fa9a1f48b189291da49c430
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATCAY LAD1 COL6A5 MFAP5 CELSR2	9.53e-05	183	111	5	99ab7a43527eb226027efbcd8c0b6a8e46fc3c93
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 AKAP12 MFAP5 CDH6 AHNAK2	9.53e-05	183	111	5	6b5eef96b28911c752a8b6c0975918c4572cec38
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATCAY LAD1 COL6A5 MFAP5 CELSR2	9.53e-05	183	111	5	28916f0597690ff534578be2cb715b485cb1de1a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 HECW1 ADGRV1 MYO15A UNC80	9.78e-05	184	111	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	COPD-Stromal-Pericyte\|COPD / Disease state, Lineage and Cell class	MATN3 LAMC3 AKAP12 PXDN CDH6	9.78e-05	184	111	5	a56264a22dfc2d3672b20134ab7c3c7c23da5ae1
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DBN1 APP AKAP12 KANK3 BHMT2	9.78e-05	184	111	5	1a4297b9d3cc4744bea0408fd5ee7b33ba2a1d78
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 HECW1 ADGRV1 MYO15A UNC80	9.78e-05	184	111	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 HECW1 ADGRV1 MYO15A UNC80	9.78e-05	184	111	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 AKAP12 MFAP5 CDH6 AHNAK2	9.78e-05	184	111	5	5cfc19ffb9f074bdf0d81c86e212a708ec141631
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LARGE2 ADGRV1 TXK ITPR3 CDH1	9.78e-05	184	111	5	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal-Cortical_neuron\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	USP11 ATCAY DBN1	9.83e-05	36	111	3	25fd4cf19f2ed94f99600c18383b17f86bb17ef5
ToppCell	Endothelial-B-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	DBN1 AKAP12 KANK3 BHMT2 HOMER3	1.00e-04	185	111	5	133c9dc64d564dae4aeeeca22f386aa3f13fa980
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	APP PRX PXDN KANK3 HOMER3	1.03e-04	186	111	5	f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DBN1 APP AKAP12 KANK3 HOMER3	1.03e-04	186	111	5	30dd4164c101006c8d95922d89652b82dbe4b5ea
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFX4 PRX BHMT2 CDH1 UNC80	1.03e-04	186	111	5	ea936e66ae4b7b40564711fad60ac0137327995f
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DBN1 APP AKAP12 KANK3 HOMER3	1.03e-04	186	111	5	eeacf59a9e6bf1c9fd59b6b13d35e8abae228cf0
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 PCDHGA7 TNFAIP2 PCDHGA8 MUSK	1.03e-04	186	111	5	f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|356C / Donor, Lineage, Cell class and subclass (all cells)	APP PRX PXDN KANK3 HOMER3	1.03e-04	186	111	5	2b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	LRFN1 HECW1 GPR61 DDX24 UNC80	1.05e-04	187	111	5	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|IPF / Disease state, Lineage and Cell class	LAD1 ITPR3 PXDN CDH1 CDH6	1.05e-04	187	111	5	19d6a404fc3651d98a93e3848e372df51a239c57
ToppCell	COVID-19-kidney-Stressed_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	HEXB DPYS HECW1 BHMT2 CDH6	1.05e-04	187	111	5	acd305475f3609800af0d7bc68d83ef41228080b
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	PCDHGA7 APP PRX PXDN KANK3	1.08e-04	188	111	5	fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|343B / Donor, Lineage, Cell class and subclass (all cells)	PCDHGA7 APP PRX PXDN KANK3	1.08e-04	188	111	5	cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HEXB DPYSL2 FN1 RPSA ELFN1	1.11e-04	189	111	5	0a490730cdc912d5233de59057550de0e4065747
ToppCell	droplet-Heart-nan-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDPR TRUB2 PRX CELSR2 KIF19	1.11e-04	189	111	5	0493f7b79127c207fd7ade778ef4810500495d7e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 LAMC3 RET AKAP12 MUSK	1.14e-04	190	111	5	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 LAMC3 RET AKAP12 MUSK	1.14e-04	190	111	5	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	21-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	AKAP12 PXDN KANK3 DCHS1 HOMER3	1.14e-04	190	111	5	bce09634acbc2cfd53666328e8aed8bf8835f845
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 APP PRX PXDN KANK3	1.14e-04	190	111	5	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APP AKAP12 KANK3 BHMT2 HOMER3	1.14e-04	190	111	5	6b704deeb44e1ffa10e604d0e5612b022f6cd9a6
ToppCell	21-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	AKAP12 PXDN KANK3 DCHS1 HOMER3	1.14e-04	190	111	5	08437396a98ca9526f69c3a74bbf2929f3c68b8e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPYS GALNT2 HECW1 BHMT2 CDH6	1.16e-04	191	111	5	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPYS GALNT2 HECW1 BHMT2 CDH6	1.16e-04	191	111	5	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 APP PRX PXDN KANK3	1.16e-04	191	111	5	f229abf69a1217194f74b0502486907e07dba989
ToppCell	Control-Endothelial-VE_Capillary_B\|Control / Disease state, Lineage and Cell class	FAT4 PRX AKAP12 PXDN KANK3	1.16e-04	191	111	5	322237793a1278bafb14e63cab688b353e352dcc
ToppCell	Basal_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	LARGE2 ZNF711 CELSR2 CDH6 AHNAK2	1.16e-04	191	111	5	a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DBN1 APP AKAP12 KANK3 BHMT2	1.19e-04	192	111	5	291df12b4b5ff11fbaa43033692b8f4b5cdf65a1
ToppCell	PBMC-Severe-cDC_0\|Severe / Compartment, Disease Groups and Clusters	PRX UBXN11 CELSR2 TNFAIP2 DMPK	1.19e-04	192	111	5	4f4774b925058191673b4ba4b4d05b8b37f61795
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DBN1 APP AKAP12 KANK3 BHMT2	1.19e-04	192	111	5	35ffe7aa9ffab85eac3326651e901c39d0119650
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LARGE2 LAD1 ADGRV1 ITPR3 CDH1	1.19e-04	192	111	5	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 RPSA DBN1 MFAP5 TNFAIP2	1.19e-04	192	111	5	2d9e2262f1342fe17735f21f733c029d1275e955
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LARGE2 LAD1 ADGRV1 ITPR3 CDH1	1.22e-04	193	111	5	5f0eba7b1440beb891d94a288f7f18a4e13c3a88
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LARGE2 LAD1 ADGRV1 ITPR3 CDH1	1.25e-04	194	111	5	413112ee8df7407fd418d57c2ff11aad3a6ec259
ToppCell	LAM-Endothelial\|LAM / Condition, Lineage and Cell class	DBN1 APP PRX AKAP12 KANK3	1.25e-04	194	111	5	1241e3e75414b619abc9431627619f5c194ec930
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LARGE2 LAD1 ADGRV1 ITPR3 CDH1	1.28e-04	195	111	5	b78db0d929be6b04055805ea5ffecc56c47ba956
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT4 AKAP12 MFAP5 CDH6 AHNAK2	1.28e-04	195	111	5	6524ee7bdc70bb5955dd6a6f134a8e6d8b5f2b39
ToppCell	distal-Endothelial-Lymphatic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DBN1 AKAP12 KANK3 BHMT2 HOMER3	1.28e-04	195	111	5	f45c1349932ee7eb419cced8a4fdedae3610953f
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LARGE2 MATN3 MFAP5 TNFAIP2	1.29e-04	103	111	4	39d8cfb899ca88c72ebe021d66cc21ae2eb6a1cc
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LARGE2 MATN3 MFAP5 TNFAIP2	1.29e-04	103	111	4	01a7baaa0c3903bd00e37717856d2c1ac21bf2c8
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-myocytic\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT4 AKAP12 MFAP5 CDH6 AHNAK2	1.31e-04	196	111	5	20dc9b25ecc23b6e6e52bbab8b5a404f3245ca37
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	PCDHGA3 MATN3 RET PXDN KANK3	1.35e-04	197	111	5	f7ef62d78336812573148f8bfce401877ec4e29c
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	APP AKAP12 PXDN KANK3 HOMER3	1.35e-04	197	111	5	15d1e0dffee8f5ba8cee37adfbfa0551a0cd5e15
Drug	lactofen	DPYS PCDHGA11 PCDHGA3 PCDHGA2 CELSR2 PCDHGA8	2.83e-06	81	111	6	CID000062276
Drug	3-hydroxy-(D/L)-kynurenine; Down 200; 9.2uM; MCF7; HT_HG-U133A_EA	PNKP DBN1 RET PRDM2 SLC38A10 CELSR2 PES1 HOMER3	6.05e-06	199	111	8	1109_DN
Disease	Sarcosine measurement	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	1.80e-12	23	109	7	EFO_0021668
Disease	mental development measurement	PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	3.51e-12	25	109	7	EFO_0008230
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 PCDHGA8	2.34e-10	71	109	8	EFO_0007878, EFO_0007979
Disease	metabolite measurement, body weight gain	ACSM4 KIF19 MUSK	1.05e-05	12	109	3	EFO_0004566, EFO_0004725
Disease	Van Maldergem Wetzburger Verloes syndrome	FAT4 DCHS1	1.35e-05	2	109	2	C1832390
Disease	Van Maldergem syndrome	FAT4 DCHS1	1.35e-05	2	109	2	cv:C1832390
Disease	Periventricular gray matter heterotopia	FAT4 DCHS1	1.35e-05	2	109	2	C1849173
Disease	Heterotopia, Periventricular, Autosomal Recessive	FAT4 DCHS1	4.05e-05	3	109	2	C1842563
Disease	transcobalamin-2 measurement	KANK3 PES1	8.07e-05	4	109	2	EFO_0802139
Disease	lymphocyte count	ACACA FN1 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 ICAM3 NUP88 ITPR2 ZNF469 PHLPP1 HSF2 PCDHGA8	9.45e-05	1464	109	16	EFO_0004587
Disease	muscular disease (implicated_via_orthology)	ACACA ACACB	1.34e-04	5	109	2	DOID:0080000 (implicated_via_orthology)
Disease	phosphatidylcholine 38:4 measurement	ADGRV1 ITPR2 MUSK	1.50e-04	28	109	3	EFO_0010386
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	GALNT2 ACACB CELSR2 KANK3 MUSK RNF111	1.51e-04	215	109	6	EFO_0008317, EFO_0008591
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	GALNT2 ACACB CELSR2 KANK3 MUSK RNF111	1.72e-04	220	109	6	EFO_0004529, EFO_0008317
Disease	total cholesterol measurement, very low density lipoprotein cholesterol measurement	GALNT2 ACACB CELSR2 KANK3 MUSK RNF111	1.89e-04	224	109	6	EFO_0004574, EFO_0008317
Disease	cholesteryl ester measurement, very low density lipoprotein cholesterol measurement	GALNT2 ACACB CELSR2 KANK3 MUSK RNF111	1.94e-04	225	109	6	EFO_0008317, EFO_0010351
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	GALNT2 ACACB CELSR2 KANK3 MUSK RNF111	2.13e-04	229	109	6	EFO_0004639, EFO_0008317
Disease	Pena-Shokeir syndrome type I	NUP88 MUSK	3.73e-04	8	109	2	C1276035
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	GALNT2 ACACB CELSR2 KANK3 MUSK	3.87e-04	166	109	5	EFO_0004530, EFO_0004611
Disease	mean platelet volume	GALNT2 PCDHGA11 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA3 PCDHGA2 NUP88 TXK PCDHGA8 MUSK	3.94e-04	1020	109	12	EFO_0004584
Disease	very low density lipoprotein cholesterol measurement	GALNT2 ACACB CELSR2 KANK3 MUSK RNF111	4.19e-04	260	109	6	EFO_0008317
Disease	Thyroid carcinoma	RET PRDM2 CDH1	5.82e-04	44	109	3	C0549473
Disease	3-methyl-2-oxobutyrate measurement	FAT4 PES1	5.97e-04	10	109	2	EFO_0021020
Disease	apolipoprotein B measurement	DCHS2 GALNT2 FN1 ACACB LLGL1 GPR61 CELSR2 MUSK PPM1N	8.02e-04	663	109	9	EFO_0004615
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR2 ITPR3	8.71e-04	12	109	2	DOID:1441 (implicated_via_orthology)
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	GALNT2 ACACB SPG11 CELSR2 MUSK	8.99e-04	200	109	5	EFO_0004611, EFO_0020945
Disease	iron deficiency anemia (biomarker_via_orthology)	FN1 APP	1.03e-03	13	109	2	DOID:11758 (biomarker_via_orthology)
Disease	level of Phosphatidylcholine (16:0_18:3) in blood serum	MUSK RNF111	1.03e-03	13	109	2	OBA_2045072
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	GALNT2 SPG11 LLGL1 CELSR2	1.07e-03	121	109	4	EFO_0008595, EFO_0020943
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	MUSK RNF111	1.20e-03	14	109	2	OBA_2045142
Disease	beta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement	FAT4 HECW1	1.20e-03	14	109	2	EFO_0004670, EFO_0006794
Disease	obesity (implicated_via_orthology)	DCHS2 FAT4 ITPR2 ITPR3 DCHS1	1.24e-03	215	109	5	DOID:9970 (implicated_via_orthology)
Disease	free cholesterol to total lipids in medium HDL percentage	GALNT2 CELSR2 MUSK	1.44e-03	60	109	3	EFO_0022282
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	GALNT2 ACACB CELSR2 KANK3 MUSK	1.49e-03	224	109	5	EFO_0004530, EFO_0008317
Disease	triglycerides in medium LDL measurement	GALNT2 CELSR2 MUSK	1.58e-03	62	109	3	EFO_0022322
Disease	Neoplastic Cell Transformation	MYD88 FN1 PHLPP1 CDH1	1.79e-03	139	109	4	C0007621
Disease	triglycerides in small LDL measurement	GALNT2 CELSR2 KANK3	1.81e-03	65	109	3	EFO_0022323
Disease	cholesterol in very large VLDL measurement	GALNT2 CELSR2 MUSK	1.81e-03	65	109	3	EFO_0022230
Disease	total lipids in large VLDL	GALNT2 CELSR2 MUSK	1.98e-03	67	109	3	EFO_0022175
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	GALNT2 SPG11 LLGL1	1.98e-03	67	109	3	EFO_0008595, EFO_0020946
Disease	free cholesterol in large VLDL measurement	GALNT2 CELSR2 MUSK	2.06e-03	68	109	3	EFO_0022265
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	GALNT2 ACACB CELSR2 MUSK RNF111	2.12e-03	243	109	5	EFO_0004612, EFO_0020944
Disease	level of Phosphatidylethanolamine (18:0_20:4) in blood serum	MUSK RNF111	2.22e-03	19	109	2	OBA_2045140
Disease	level of Sphingomyelin (d38:2) in blood serum	KANK3 MUSK	2.22e-03	19	109	2	OBA_2045179
Disease	sodium-coupled monocarboxylate transporter 1 measurement	CELSR2 MUSK	2.22e-03	19	109	2	EFO_0802076
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	GALNT2 ACAT2 CELSR2 MUSK	2.54e-03	153	109	4	EFO_0004611, EFO_0020946
Disease	free cholesterol to total lipids in large LDL percentage	GALNT2 CELSR2 KANK3	2.63e-03	74	109	3	EFO_0022280
Disease	colorectal carcinoma (is_implicated_in)	MYD88 AKAP12	2.98e-03	22	109	2	DOID:0080199 (is_implicated_in)
Disease	level of Sphingomyelin (d40:2) in blood serum	NUP88 MUSK	3.25e-03	23	109	2	OBA_2045181
Disease	level of Phosphatidylethanolamine (16:0_18:2) in blood serum	MUSK RNF111	3.54e-03	24	109	2	OBA_2045136
Disease	brain stem volume measurement	RFX4 EIF2AK3	3.54e-03	24	109	2	EFO_0010605
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	GALNT2 ACACB LLGL1 CELSR2 MUSK	3.66e-03	276	109	5	EFO_0004612, EFO_0020943

Protein segments in the cluster

Peptide	Gene	Start	Entry
ADETPAVQAVLRADT	ABCF1	371	Q8NE71
LTVTPAAAVLRAEAE	ELFN1	681	P0C7U0
EALAASSPVRVAEEV	COX18	56	Q8N8Q8
AAAEVTVEDAEALPA	EIF2AK3	66	Q9NZJ5
VEVDAAVTPEERHLS	APP	736	P05067
ASVTEPLEQVEAEAA	AKAP12	916	Q02952
VSEAELTPEAVTAAE	AKAP12	966	Q02952
RVPETVADARQSIDV	FDX1	166	P10109
VVALLTVTDADSPAA	FAT4	376	Q6V0I7
REATIAVNILDDTVP	ADGRV1	3601	Q8WXG9
VAVETRTVELSIPAD	ACACA	1986	Q13085
VASEEVAPAVESIVL	ACSM4	166	P0C7M7
PVTGAVTTAEELDRE	CELSR2	236	Q9HCU4
VDSPYVVAVRIADET	R3HCC1L	391	Q7Z5L2
TVAVADSIPEVLADL	PCDHGA7	661	Q9Y5G6
ATVTLTVAVADRIPD	PCDHGA2	656	Q9Y5H1
AEVREEIILTEAAAP	RFX4	491	Q33E94
PAELARVIVLDTDVT	LARGE2	191	Q8N3Y3
ATFTVTVAVADRIPD	PCDHGA5	656	Q9Y5G8
TVAVADSIPEVLTEL	PCDHGA8	661	Q9Y5G5
LTVAVADSIPEVLAD	PCDHGA11	661	Q9Y5H2
IVSVPLSEVRDLDFA	ITPR2	431	Q14571
IVSVPVSEIRDLDFA	ITPR3	431	Q14573
LELSDVPVEQAVSVA	LLGL1	541	Q15334
VIAVETRTVEVAVPA	ACACB	2096	O00763
LTVAVADSIPDVLAD	PCDHGA4	691	Q9Y5G9
TPDGATVEVTVRVAD	DCHS1	121	Q96JQ0
ATVTLTVAVADRIPD	PCDHGA6	656	Q9Y5G7
ASASERLPSVEEAEV	LAD1	56	O00515
VPEAVFSEVARISSL	NMBR	176	P28336
VPEVGLRDVASESVA	GPR61	31	Q9BZJ8
DTLDIGPADTRVAVV	MATN3	111	O15232
TPLTVESAVDARDAI	MYO15A	1541	Q9UKN7
SRPEEVEAEAVNRAI	DPYSL2	226	Q16555
ELSRPAEEAAVITEA	HECW1	411	Q76N89
EALREVESQAAPAVA	LRFN1	606	Q9P244
EVAPVENRSALVSED	ATCAY	351	Q86WG3
RPEAVEAEATLRAIT	DPYS	221	Q14117
VAEDRTRVVSPIIDV	GALNT2	241	Q10471
KSRDVPVDAVATEAA	DDX59	36	Q5T1V6
VAELEAQAASEVTPT	HOMER3	231	Q9NSC5
VEAAEATPVALDSDT	CCDC97	41	Q96F63
PEDAVVSSADVALAL	PDPR	181	Q8NCN5
VSAEPEVAALARQAE	PPM1N	251	Q8N819
VAAVDSSVPRTAELA	MYD88	131	Q99836
EEVAPVSVSDAALLA	MPHOSPH10	536	O00566
DAVTVPVEILSTDAR	LMTK2	861	Q8IWU2
TPVAEQIERALDEVT	DBN1	346	Q16643
SDSLAAEIVTPEIRE	HOOK3	451	Q86VS8
AVPAAEAEAEVTLRE	DMPK	456	Q09013
DPATDETVLAVLADI	MFAP5	51	Q13361
ETVLAVLADIAPSTD	MFAP5	56	Q13361
AVEEPAEVTATVLAS	ICAM3	166	P32942
QEAVSSPVLEVAAEA	MEI1	421	Q5TIA1
EPEVATVRVSIAVLD	DCHS2	391	Q6V1P9
PEVAAARESIAALVD	KIF19	506	Q2TAC6
ATVTLTVAVADRIPD	PCDHGA3	656	Q9Y5H0
ESLQPVAAAVEERAT	BOD1L1	2166	Q8NFC6
AVEVLKESDRPVAVT	BHMT2	161	Q9H2M3
VRAVAAASLVPVVES	BTAF1	446	O14981
STVSDVPRDLEVVAA	FN1	1536	P02751
RDETAVVCPVIDTID	GALNT4	246	Q8N4A0
PILVVLASAESEDEV	COL6A5	136	A8TX70
DIVIPSAAVISRAET	IL23R	216	Q5VWK5
TPEVTNAALDEAVTI	MGARP	176	Q8TDB4
SVSVRAPEENTAAIV	CEP192	831	Q8TEP8
LTAIAESPVIEVETE	CEP192	1486	Q8TEP8
DTVIESEALPSDIAA	DDX24	301	Q9GZR7
REVAAEAVPETREAG	KANK3	301	Q6NY19
ETREAGVEAAPETVE	KANK3	321	Q6NY19
AEAPRLIEESSVDEV	PRPSAP1	291	Q14558
DSATVRIVVEDVDEP	CDH6	366	P55285
VVPDEVATIAAEVTS	FLAD1	151	Q8NFF5
VVQVAEAARAPSVSA	HEXB	36	P07686
ARLSAQDPVVAVAED	SLC38A10	426	Q9HBR0
ATVTVDVLDVNEAPI	CDH1	471	P12830
PEIAAAIEEERASAR	PRDM2	146	Q13029
VRLEPLTEAEASEAT	HSF2	501	Q03933
DVEVAESPLRVLAET	NUP88	511	Q99567
AARAIVAIENPADVS	RPSA	61	P08865
SEVARAEVEINIPVT	RPE65	511	Q16518
EIALPGEVSARDTVT	SMG1	2106	Q96Q15
AVDPDVSARTVFIDV	MORC4	61	Q8TE76
IEADPLTTTREVAEE	SETMAR	421	Q53H47
ESRALLSASPEVVVA	PNKP	356	Q96T60
AVAVTLVESVCPDAA	INTS5	811	Q6P9B9
VATARGAADEVEVEP	NFATC2IP	61	Q8NCF5
AAVAARQETDSIPLV	ABTB1	426	Q969K4
VSSPADVAEKADRII	HIBADH	86	P31937
DVEVSLPSVEVDVEA	AHNAK2	1121	Q8IVF2
DVEVSLPSVEVDVEA	AHNAK2	1451	Q8IVF2
DVEVSLPSVEVDVEA	AHNAK2	1781	Q8IVF2
DVEVSLPSVEVDVEA	AHNAK2	2936	Q8IVF2
DVEVSLPSVEVDVEA	AHNAK2	3926	Q8IVF2
TAEEVAALIRSLPVE	PRPF8	1841	Q6P2Q9
PDTVAELVAEEVTRE	SPG11	2046	Q96JI7
PAELEVGSAEVIVES	ZBTB48	631	P10074
AAPVETLENIIATVD	TNFAIP2	486	Q03169
SQVETVPAAREEIAA	UNC80	2386	Q8N2C7
VPAAREEIAATAALA	UNC80	2391	Q8N2C7
ASLARVVVPATEEEA	PES1	281	O00541
VLKRATVAPEDVSEV	ACAT2	41	Q9BWD1
VPSGSIDEDVVVIEA	RNF111	291	Q6ZNA4
ERVSALEVLPDRVAT	SPIN1	106	Q9Y657
EGAVSVVVPTLDVAA	PRX	316	Q9BXM0
DPFVATSIVEAIATV	PXDN	621	Q92626
TVVATLRVFDADVVP	RET	291	P07949
REESILPVSADVISD	ZNF469	2616	Q96JG9
PTFAELLRAVTEIAE	TXK	511	P42681
VPVGAAVTADETEVL	ZBTB17	681	Q13105
AAAEEREEAAVAAPT	ZNF316	551	A6NFI3
SVEEAVEAVRNVPDA	PHLPP1	1381	O60346
DAIRAATPQVAAELE	TRUB2	281	O95900
PEAVLVSDVVTDDGI	ZNF711	46	Q9Y462
AAVAAAAAVTEDREP	USP11	56	P51784
IVVETPTLAAERERS	UBXN11	371	Q5T124
PLTSDIVSEEVLVAD	ZFY	166	P08048
VIDVSTADRAIPESQ	GEMIN4	461	P57678
LRTAVAEVLPEAESV	LAMC3	1221	Q9Y6N6
AEVLPEAESVLATVQ	LAMC3	1226	Q9Y6N6
TTPLETVDALVEEVA	MUSK	31	O15146