Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	1.08e-05	2	66	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	1.08e-05	2	66	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	1.08e-05	2	66	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	1.08e-05	2	66	2	GO:0004354
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	3.22e-05	3	66	2	GO:0018858
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	6.43e-05	4	66	2	GO:0102391
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN4A SCN8A SCN9A	8.49e-05	26	66	3	GO:0005248
GeneOntologyMolecularFunction	L-leucine binding	GLUD1 GLUD2	2.24e-04	7	66	2	GO:0070728
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	2.97e-04	8	66	2	GO:0004321
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	5.81e-04	11	66	2	GO:0031956
GeneOntologyMolecularFunction	sodium channel activity	SCN4A SCN8A SCN9A	6.79e-04	52	66	3	GO:0005272
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPV1 KCNH1 SCN4A SCN8A SCN9A UNC80	9.39e-04	343	66	6	GO:0005261
GeneOntologyMolecularFunction	sodium ion binding	SCN8A SCN9A	9.54e-04	14	66	2	GO:0031402
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors	GLUD1 GLUD2	1.97e-03	20	66	2	GO:0016638
GeneOntologyMolecularFunction	NAD+ binding	GLUD1 GLUD2	1.97e-03	20	66	2	GO:0070403
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM2A ACSM2B	2.17e-03	21	66	2	GO:0016408
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM2A ACSM2B	3.32e-03	26	66	2	GO:0015645
GeneOntologyMolecularFunction	alkali metal ion binding	SCN8A SCN9A	3.32e-03	26	66	2	GO:0031420
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM2A ACSM2B	3.58e-03	27	66	2	GO:0016405
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPV1 KCNH1 SCN4A SCN8A SCN9A UNC80	4.05e-03	459	66	6	GO:0005216
GeneOntologyMolecularFunction	ATP-dependent activity	MDN1 DDX54 CHD9 MTREX ACSM2A ACSM2B DNAH11	4.07e-03	614	66	7	GO:0140657
GeneOntologyBiologicalProcess	detection of temperature stimulus involved in sensory perception of pain	MMP24 TRPV1 SCN9A	7.72e-05	26	66	3	GO:0050965
GeneOntologyBiologicalProcess	glutamate biosynthetic process	GLUD1 GLUD2	1.00e-04	5	66	2	GO:0006537
GeneOntologyBiologicalProcess	detection of temperature stimulus involved in sensory perception	MMP24 TRPV1 SCN9A	1.19e-04	30	66	3	GO:0050961
GeneOntologyBiologicalProcess	response to aluminum ion	GLUD1 GLUD2	1.50e-04	6	66	2	GO:0010044
GeneOntologyBiologicalProcess	detection of temperature stimulus	MMP24 TRPV1 SCN9A	1.59e-04	33	66	3	GO:0016048
GeneOntologyBiologicalProcess	carboxylic acid biosynthetic process	OSBPL2 GLUD1 BAAT GLUD2 ACSM2A ELOVL2 ACSM2B	1.89e-04	374	66	7	GO:0046394
GeneOntologyBiologicalProcess	organic acid biosynthetic process	OSBPL2 GLUD1 BAAT GLUD2 ACSM2A ELOVL2 ACSM2B	1.99e-04	377	66	7	GO:0016053
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN4A SCN8A SCN9A	2.07e-04	36	66	3	GO:0086010
GeneOntologyBiologicalProcess	calcium ion homeostasis	S100B MICU3 CIB2 OSBPL2 KCNH1 PYGM CDH5	2.41e-04	389	66	7	GO:0055074
GeneOntologyBiologicalProcess	sensory perception of temperature stimulus	MMP24 TRPV1 SCN9A	2.44e-04	38	66	3	GO:0050951
GeneOntologyBiologicalProcess	glutamate catabolic process	GLUD1 GLUD2	2.79e-04	8	66	2	GO:0006538
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception of pain	MMP24 TRPV1 SCN9A	3.52e-04	43	66	3	GO:0062149
GeneOntologyBiologicalProcess	acyl-CoA metabolic process	BAAT ACSM2A ELOVL2 ACSM2B	4.13e-04	109	66	4	GO:0006637
GeneOntologyBiologicalProcess	thioester metabolic process	BAAT ACSM2A ELOVL2 ACSM2B	4.13e-04	109	66	4	GO:0035383
GeneOntologyCellularComponent	sodium channel complex	SCN4A SCN8A SCN9A UNC80	2.03e-06	29	66	4	GO:0034706
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN4A SCN8A SCN9A	1.98e-05	17	66	3	GO:0001518
GeneOntologyCellularComponent	checkpoint clamp complex	HUS1 RAD9B	9.76e-05	5	66	2	GO:0030896
GeneOntologyCellularComponent	cation channel complex	MICU3 KCNH1 SCN4A SCN8A SCN9A UNC80	9.80e-05	235	66	6	GO:0034703
Domain	Na_channel_asu	SCN4A SCN8A SCN9A	4.97e-06	10	66	3	IPR001696
Domain	Na_trans_assoc	SCN4A SCN8A SCN9A	4.97e-06	10	66	3	IPR010526
Domain	Na_trans_assoc	SCN4A SCN8A SCN9A	4.97e-06	10	66	3	PF06512
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	1.23e-05	2	66	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	1.23e-05	2	66	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	1.23e-05	2	66	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	1.23e-05	2	66	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	1.23e-05	2	66	2	PF00208
Domain	ELFV_dehydrog	GLUD1 GLUD2	1.23e-05	2	66	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	1.23e-05	2	66	2	IPR033524
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	1.23e-05	2	66	2	IPR033922
Domain	Secretoglobin_1C1/2	SCGB1C2 SCGB1C1	1.23e-05	2	66	2	IPR028659
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	1.23e-05	2	66	2	PS00074
Domain	Ion_trans_dom	TRPV1 KCNH1 SCN4A SCN8A SCN9A	5.15e-05	114	66	5	IPR005821
Domain	Ion_trans	TRPV1 KCNH1 SCN4A SCN8A SCN9A	5.15e-05	114	66	5	PF00520
Domain	Na_trans_cytopl	SCN8A SCN9A	1.83e-04	6	66	2	PF11933
Domain	Na_trans_cytopl	SCN8A SCN9A	1.83e-04	6	66	2	IPR024583
Domain	SCGB	SCGB1C2 SCGB1C1	4.36e-04	9	66	2	PS51311
Domain	EF-hand-dom_pair	SYNRG S100B MICU3 CIB2 SCN8A SCN9A	5.24e-04	287	66	6	IPR011992
Domain	Uteroglobin	SCGB1C2 SCGB1C1	5.43e-04	10	66	2	PF01099
Domain	Secretoglobin	SCGB1C2 SCGB1C1	6.63e-04	11	66	2	IPR016126
Domain	Channel_four-helix_dom	SCN4A SCN8A SCN9A	1.08e-03	57	66	3	IPR027359
Domain	-	SCN4A SCN8A SCN9A	1.08e-03	57	66	3	1.20.120.350
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH11	1.09e-03	14	66	2	IPR011704
Domain	AAA_5	MDN1 DNAH11	1.09e-03	14	66	2	PF07728
Domain	AMP-bd_C	ACSM2A ACSM2B	1.62e-03	17	66	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	1.62e-03	17	66	2	PF13193
Domain	IQ	SCN4A SCN8A SCN9A	2.03e-03	71	66	3	PF00612
Domain	IQ	SCN4A SCN8A SCN9A	2.95e-03	81	66	3	SM00015
Domain	AMP-binding_CS	ACSM2A ACSM2B	3.78e-03	26	66	2	IPR020845
Domain	IQ_motif_EF-hand-BS	SCN4A SCN8A SCN9A	3.98e-03	90	66	3	IPR000048
Domain	IQ	SCN4A SCN8A SCN9A	4.36e-03	93	66	3	PS50096
Domain	AMP_BINDING	ACSM2A ACSM2B	4.38e-03	28	66	2	PS00455
Domain	ZnMc	MEP1B MMP24	4.70e-03	29	66	2	SM00235
Domain	Peptidase_Metallo	MEP1B MMP24	4.70e-03	29	66	2	IPR006026
Domain	AMP-binding	ACSM2A ACSM2B	5.02e-03	30	66	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSM2A ACSM2B	5.02e-03	30	66	2	IPR000873
Domain	Helicase_C	DDX54 CHD9 MTREX	6.44e-03	107	66	3	PF00271
Domain	HELICc	DDX54 CHD9 MTREX	6.44e-03	107	66	3	SM00490
Domain	Helicase_C	DDX54 CHD9 MTREX	6.61e-03	108	66	3	IPR001650
Domain	HELICASE_CTER	DDX54 CHD9 MTREX	6.78e-03	109	66	3	PS51194
Domain	HELICASE_ATP_BIND_1	DDX54 CHD9 MTREX	6.78e-03	109	66	3	PS51192
Domain	DEXDc	DDX54 CHD9 MTREX	6.78e-03	109	66	3	SM00487
Domain	Helicase_ATP-bd	DDX54 CHD9 MTREX	6.95e-03	110	66	3	IPR014001
Domain	TPR-like_helical_dom	POLR1A TRAPPC12 P3H2 EDRF1	9.30e-03	233	66	4	IPR011990
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	MMP24 TRPV1 SCN8A SCN9A	2.58e-05	46	53	4	M46450
Pathway	REACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE	ACSM2A ACSM2B	2.06e-04	6	53	2	MM14693
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN4A SCN8A SCN9A	2.09e-04	31	53	3	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN4A SCN8A SCN9A	2.30e-04	32	53	3	M27455
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	2.88e-04	7	53	2	MM14598
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	4.91e-04	9	53	2	M26968
Pathway	WP_ATR_SIGNALING	HUS1 RAD9B	7.46e-04	11	53	2	M39507
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS	GLUD1 GLUD2	7.46e-04	11	53	2	MM14866
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS	GLUD1 GLUD2 CHD9	1.15e-03	55	53	3	M27145
Pathway	REACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM	GLUD1 GLUD2	1.23e-03	14	53	2	M27851
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	GYG1 PYGM	1.23e-03	14	53	2	MM15391
Pathway	REACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM	GLUD1 GLUD2	1.23e-03	14	53	2	MM15570
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	GYG1 PYGM	1.23e-03	14	53	2	M19193
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN4A SCN8A SCN9A	5.44e-07	9	66	3	16382098
Pubmed	SCGB1C1 Plays a Critical Role in Suppression of Allergic Airway Inflammation through the Induction of Regulatory T Cell Expansion.	SCGB1C2 SCGB1C1	3.55e-06	2	66	2	38892470
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	3.55e-06	2	66	2	16521160
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	3.55e-06	2	66	2	15750346
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	3.55e-06	2	66	2	1711373
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	3.55e-06	2	66	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	3.55e-06	2	66	2	28621566
Pubmed	State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.	SCN4A SCN9A	3.55e-06	2	66	2	18079277
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	3.55e-06	2	66	2	32078638
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	3.55e-06	2	66	2	20529287
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	3.55e-06	2	66	2	23595828
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	3.55e-06	2	66	2	25124006
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	3.55e-06	2	66	2	23673664
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	3.55e-06	2	66	2	21621574
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	3.55e-06	2	66	2	39052831
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	3.55e-06	2	66	2	24442550
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	3.55e-06	2	66	2	28911206
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	3.55e-06	2	66	2	27137930
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	3.55e-06	2	66	2	26440896
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	3.55e-06	2	66	2	22875990
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	3.55e-06	2	66	2	12742085
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	3.55e-06	2	66	2	15578726
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	3.55e-06	2	66	2	15044002
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	3.55e-06	2	66	2	22138648
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	3.55e-06	2	66	2	34220417
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	3.55e-06	2	66	2	26241911
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	3.55e-06	2	66	2	19634011
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	3.55e-06	2	66	2	21446915
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	3.55e-06	2	66	2	18688271
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	3.55e-06	2	66	2	22658952
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	3.55e-06	2	66	2	29948332
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	3.55e-06	2	66	2	38060673
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	3.55e-06	2	66	2	24593767
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	3.55e-06	2	66	2	38124277
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	3.55e-06	2	66	2	37154294
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	3.55e-06	2	66	2	19015267
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	3.55e-06	2	66	2	22924626
Pubmed	Sodium channel slow inactivation interferes with open channel block.	SCN8A SCN9A	3.55e-06	2	66	2	27174182
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	3.55e-06	2	66	2	19448744
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	3.55e-06	2	66	2	11032875
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	3.55e-06	2	66	2	11950837
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	3.55e-06	2	66	2	29943084
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	3.55e-06	2	66	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	3.55e-06	2	66	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	3.55e-06	2	66	2	27422263
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SRRM1 MDN1 DDX54 GON4L MTREX FER1L6	5.64e-06	234	66	6	36243803
Pubmed	Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.	GLUD1 GLUD2	1.06e-05	3	66	2	29784783
Pubmed	The structure of apo human glutamate dehydrogenase details subunit communication and allostery.	GLUD1 GLUD2	1.06e-05	3	66	2	12054821
Pubmed	Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.	GLUD1 GLUD2	1.06e-05	3	66	2	31704028
Pubmed	Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors.	MEP1B ADGRF3	1.06e-05	3	66	2	24114056
Pubmed	Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.	GLUD1 GLUD2	1.06e-05	3	66	2	29229616
Pubmed	Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.	GLUD1 GLUD2	1.06e-05	3	66	2	30002133
Pubmed	Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.	GLUD1 GLUD2	1.06e-05	3	66	2	30315226
Pubmed	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.	SCN4A SCN9A	1.06e-05	3	66	2	20038812
Pubmed	Isolation of a human brain cDNA for glutamate dehydrogenase.	GLUD1 GLUD2	1.06e-05	3	66	2	3585334
Pubmed	FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7.	TRPV1 SCN9A	1.06e-05	3	66	2	28162808
Pubmed	GOT1 regulates CD8+ effector and memory T cell generation.	GLUD1 GLUD2	1.06e-05	3	66	2	36640309
Pubmed	Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes.	GLUD1 GLUD2	1.06e-05	3	66	2	37871770
Pubmed	The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.	TRPV1 SCN9A	1.06e-05	3	66	2	31285762
Pubmed	Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.	GLUD1 GLUD2	1.06e-05	3	66	2	23560106
Pubmed	Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.	GLUD1 GLUD2	1.06e-05	3	66	2	20670938
Pubmed	Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.	GLUD1 GLUD2	1.06e-05	3	66	2	24295216
Pubmed	Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.	SCN8A SCN9A	1.06e-05	3	66	2	15302875
Pubmed	Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains.	MDN1 GLUD1 GLUD2	1.46e-05	25	66	3	8858346
Pubmed	Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum.	GLUD1 GLUD2	2.12e-05	4	66	2	24872547
Pubmed	Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity.	GLUD1 GLUD2	2.12e-05	4	66	2	25721396
Pubmed	Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.	TRPV1 GFRA3	2.12e-05	4	66	2	36898840
Pubmed	The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.	GLUD1 GLUD2	2.12e-05	4	66	2	23663782
Pubmed	GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels.	GLUD1 GLUD2	2.12e-05	4	66	2	39121856
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	2.12e-05	4	66	2	32830538
Pubmed	A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14.	GLUD1 GLUD2	2.12e-05	4	66	2	2566156
Pubmed	Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways.	SCGB1C2 SCGB1C1	3.53e-05	5	66	2	12406855
Pubmed	Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14.	GLUD1 GLUD2	3.53e-05	5	66	2	2045113
Pubmed	Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man.	GLUD1 GLUD2	3.53e-05	5	66	2	3182016
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN8A SCN9A	3.53e-05	5	66	2	22875929
Pubmed	Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage.	GLUD1 GLUD2	3.53e-05	5	66	2	7873882
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN4A SCN8A	3.53e-05	5	66	2	17724025
Pubmed	SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.	GLUD1 GLUD2	3.53e-05	5	66	2	16959573
Pubmed	Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue.	HUS1 RAD9B	3.53e-05	5	66	2	14500360
Pubmed	Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B.	S100B KCNH1	3.53e-05	5	66	2	20708613
Pubmed	Genomic organization and chromosomal localization of the mouse synexin gene.	GLUD1 GLUD2	3.53e-05	5	66	2	8053909
Pubmed	Macrophage-derived glutamine boosts satellite cells and muscle regeneration.	GLUD1 GLUD2	3.53e-05	5	66	2	33116312
Pubmed	Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.	SCN8A SCN9A	5.29e-05	6	66	2	16029194
Pubmed	Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors.	SLC32A1 TRPV1	5.29e-05	6	66	2	31104844
Pubmed	The human glutamate dehydrogenase gene family: gene organization and structural characterization.	GLUD1 GLUD2	5.29e-05	6	66	2	8486350
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN8A SCN9A	5.29e-05	6	66	2	23652591
Pubmed	MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies.	TRIM63 PYGM	5.29e-05	6	66	2	18468620
Pubmed	Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.	HUS1 RAD9B	5.29e-05	6	66	2	14611806
Pubmed	Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14.	GLUD1 GLUD2	7.40e-05	7	66	2	10454512
Pubmed	RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.	GLUD1 GLUD2	7.40e-05	7	66	2	19498109
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	FMNL3 SEPTIN8 SYNRG SEC16A	9.65e-05	125	66	4	29467281
Pubmed	Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice.	GLUD1 GLUD2	9.86e-05	8	66	2	26443267
Pubmed	The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.	TRPV1 CIB2	9.86e-05	8	66	2	38228630
Pubmed	GluD1 is a signal transduction device disguised as an ionotropic receptor.	GLUD1 GLUD2	9.86e-05	8	66	2	34135511
Pubmed	Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα.	GLUD1 GLUD2	9.86e-05	8	66	2	34857752
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	SRRM1 MDN1 POLR1A DDX54 GON4L CHD9	1.04e-04	394	66	6	27248496
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	MDN1 WDHD1 GLUD1 SEC16A MTREX PPP6R2	1.12e-04	399	66	6	37536630
Pubmed	Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.	GLUD1 GLUD2 PPP6R2	1.20e-04	50	66	3	23272104
Pubmed	Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice.	GLUD1 GLUD2	1.27e-04	9	66	2	9756038
Pubmed	Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues.	GLUD1 GLUD2	1.27e-04	9	66	2	2293612
Cytoband	16p12.3	ACSM2A ACSM2B	1.11e-03	34	66	2	16p12.3
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN4A SCN8A SCN9A	1.20e-06	9	45	3	1203
GeneFamily	Secretoglobins	SCGB1C2 SCGB1C1	5.41e-04	14	45	2	734
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	1.90e-03	26	45	2	40
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	SLC32A1 TRPV1 CIB2 P3H2 SCN9A DNASE1L3	1.87e-07	168	66	6	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	severe_influenza-pDC\|World / disease group, cell group and cell class (v2)	FMNL3 SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	2.01e-07	170	66	6	b9c08af83241666bbdbed9109cadcd088c0f647d
ToppCell	severe_influenza-pDC\|severe_influenza / disease group, cell group and cell class (v2)	FMNL3 SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	2.30e-07	174	66	6	d8d2ded5812ed3b3db4109585714a6513c13326a
ToppCell	3'_v3-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	SLC32A1 CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	2.90e-07	181	66	6	66d890a105f955dca91d6e5e6c730d1a68ee9233
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3 ELOVL2	3.09e-07	183	66	6	3b123571e10c132227aff65648b4b3c6acb4bd00
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3 ELOVL2	3.09e-07	183	66	6	df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCell	control-Myeloid-pDC\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FMNL3 SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	3.40e-07	186	66	6	fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	SLC32A1 CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	3.86e-07	190	66	6	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic\|lymph-node_spleen / Manually curated celltypes from each tissue	SLC32A1 CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	3.98e-07	191	66	6	c3ff4342e0eea1e1f071b1fbca14a6dd4df0c696
ToppCell	3'_v3-Lung-Myeloid_Dendritic\|Lung / Manually curated celltypes from each tissue	SLC32A1 S100B CIB2 P3H2 SCN9A DNASE1L3	4.49e-07	195	66	6	b748cb15846345363e8c2ee5936bb42bba3ba9a7
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KCNH1 SCN8A SCN9A UNC80 GFRA3 TBC1D17	4.77e-07	197	66	6	ff4df77117165b6b25315e29b0722cc136eba607
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chodl\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TRPV1 SCN4A SCN9A DNASE1L3 FER1L6	1.87e-06	137	66	5	5cb84392e4483f50e09fb7395e2ec98f3eb6ecf3
ToppCell	severe_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	3.89e-06	159	66	5	e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCell	severe_COVID-19-pDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	3.89e-06	159	66	5	ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FREM2 BAAT SCN9A UNC80 ACSM2B	4.26e-06	162	66	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	Influenza_Severe-pDC\|World / Disease group and Cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	4.80e-06	166	66	5	bd25ce4c03c3d6cd9d986b9be1d355da52f0f2d7
ToppCell	Influenza_Severe-pDC\|Influenza_Severe / Disease group and Cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	4.80e-06	166	66	5	b43a5cd4d28118cf6e56a435deb8ea9435608a90
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	4.94e-06	167	66	5	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	10x5'-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	5.08e-06	168	66	5	cfed36fece51871a5abbcde71f6bd5e7212357ff
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	5.54e-06	171	66	5	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	5.54e-06	171	66	5	debbb071d260639b16269c94d172766908325c58
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	5.70e-06	172	66	5	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 FGD5 CDH5 DNASE1L3 STAB1	5.70e-06	172	66	5	a6fb1bde8d942c7b5caaf7bd14de0b7ce32fda55
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SEPTIN8 S100B FGD5 CDH5 STAB1	6.03e-06	174	66	5	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	IIF-Myeloid-pDC\|IIF / Disease, Lineage and Cell Type	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	6.20e-06	175	66	5	35cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCell	mild_COVID-19-pDC\|mild_COVID-19 / disease group, cell group and cell class (v2)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	6.20e-06	175	66	5	b87f279a7519710146c49d6acccb0adedc195965
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	6.20e-06	175	66	5	97fe431f224b592b3076632d101e19136c138dcc
ToppCell	droplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 FGD5 CDH5 DNASE1L3 STAB1	6.37e-06	176	66	5	3494ffa8555e6edf4b1250e10434bae9b73ec845
ToppCell	Control-Myeloid-pDC\|Control / Disease group,lineage and cell class （2021.01.30）	SLC32A1 AGBL4 CIB2 SCN9A DNASE1L3	6.37e-06	176	66	5	baa3563973ea1a351fe028f55828463d2a51bf1a
ToppCell	droplet-Liver-Npc-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 FGD5 CDH5 DNASE1L3 STAB1	6.37e-06	176	66	5	d43f6b7828b98e1dab7b726a5f99499d65a7db80
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|myeloid / Lineage, cell class and subclass	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	6.73e-06	178	66	5	f75591988bbbeba073b66329a3437cb9b02f7648
ToppCell	Healthy/Control-pDC\|Healthy/Control / Disease group and Cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	6.73e-06	178	66	5	072b346c6bbd63f00efaceda486400a669b3ec48
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FMNL3 CIB2 P3H2 SCN9A DNASE1L3	6.92e-06	179	66	5	124da6f882968dc0d05f3edd8f3b4d61617cc214
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FMNL3 CIB2 P3H2 SCN9A DNASE1L3	6.92e-06	179	66	5	edc5ef693dc4e7ea70717b77fb908fc784dce3a2
ToppCell	moderate-Myeloid-pDC\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	7.11e-06	180	66	5	a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCell	moderate-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CIB2 MDN1 P3H2 SCN9A DNASE1L3	7.11e-06	180	66	5	1d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	S100B HASPIN ELOVL2 GFRA3 DNAH11	7.30e-06	181	66	5	3aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	S100B HASPIN ELOVL2 GFRA3 DNAH11	7.30e-06	181	66	5	997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell	3'_v3-Lung-Myeloid_Dendritic-pDC\|Lung / Manually curated celltypes from each tissue	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	7.30e-06	181	66	5	3d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCell	5'-Adult-Appendix-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	S100B HASPIN ELOVL2 GFRA3 DNAH11	7.30e-06	181	66	5	e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell	390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	S100B P3H2 TBC1D17 STAB1	7.46e-06	84	66	4	013cf97d08d0adb3697cf2a146ff5ca13c676f64
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 FGD5 CDH5 DNASE1L3 STAB1	7.50e-06	182	66	5	000ff26c51c6a1ea8770c02722523e55be83b46f
ToppCell	Healthy/Control-pDC\|World / Disease group and Cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	7.50e-06	182	66	5	97e0eee10905f2cf2bebb09e474629fc224f4397
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPNE2 FGD5 CDH5 ACSM2B STAB1	7.50e-06	182	66	5	d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell	facs-Liver-Liver_non-hepato/SCs_st\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 FGD5 CDH5 DNASE1L3 STAB1	7.50e-06	182	66	5	b906e6e584ecbe92d3030bbdc4426f244fbe0045
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|World / Lineage, cell class and subclass	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	7.91e-06	184	66	5	11619778bc773ecd1a9867330be04deaf324f31e
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	7.91e-06	184	66	5	2817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCell	systemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.12e-06	185	66	5	cc5152d3055375172bdf84f442b233c8fbd422b3
ToppCell	Leuk-UTI-Other-RBC\|Leuk-UTI / Disease, Lineage and Cell Type	CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	8.12e-06	185	66	5	5b5dd856d6efc0539d92533cff134bbc3f98be45
ToppCell	Bac-SEP-Myeloid-pDC\|Bac-SEP / Disease, Lineage and Cell Type	CIB2 P3H2 SCN9A CHD9 DNASE1L3	8.12e-06	185	66	5	3de50b2042f22b0fb62ff12c76d85cc67649a0bd
ToppCell	BAL-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.12e-06	185	66	5	f4588468e8654363f48adbe427dff10f16f1c7fe
ToppCell	BAL-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.12e-06	185	66	5	3cb816fc9541c04b4436e21d984216cfbbacff98
ToppCell	Healthy_donor-pDC\|Healthy_donor / disease group, cell group and cell class (v2)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.12e-06	185	66	5	7fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCell	Leuk-UTI-Other\|Leuk-UTI / Disease, Lineage and Cell Type	CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	8.12e-06	185	66	5	895e8087e97ac0eab3446385e6e0dd24bea7f42c
ToppCell	BAL-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.12e-06	185	66	5	c2e70405969616c28fb6379ee318e17bbcef7b49
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	31df1eafa3010bc1be6fc4d4689f1393d69b6b13
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	a07694caf7fede06a47636725bcc7f09909cdf07
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	S100B CIB2 HLA-DRA HASPIN DNASE1L3	8.34e-06	186	66	5	a558fd00053e7dd6216b01dc8e650c30cee451f1
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	eaa431ccd4cdd36fe06a44987603ec9979025aa8
ToppCell	Mild-Lymphoid-pDC\|Mild / Condition, Lineage, Cell class and cell subclass	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	7fa82972c726025d6402e5eb7bf0db3b699eba4c
ToppCell	PBMC-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	b95be984e308d4f9061274a35995ec558d434e74
ToppCell	PBMC-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	8f7949740286f64e034d1eb533ebc2c6f71ae966
ToppCell	BAL-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	b031f4e6867b6200b85f43276a34749bf5f4603f
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	95c7318e521fb6aa02e244b1e81e6b2a62107756
ToppCell	healthy_donor-Lymphocytic-Dendritic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	8.34e-06	186	66	5	916f2aeea4989ba7a29e071e348a51010f010223
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	S100B CIB2 HLA-DRA HASPIN DNASE1L3	8.34e-06	186	66	5	75b1f342be5d6dbe0e7acd924a0ca75964f6bab0
ToppCell	BAL-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	d2fbf53aac905c9896272ec5c2db28ee1a60f4be
ToppCell	PBMC-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	b70cd94c651b56dcf2e55554533a5f1130845390
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	S100B CIB2 HLA-DRA HASPIN DNASE1L3	8.34e-06	186	66	5	0c3d195077de7b4c354c127a26116438aef29244
ToppCell	control-Myeloid-pDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FMNL3 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	fccee4cfcc887358cf916d974f29627095b5ad9c
ToppCell	COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease group, lineage and cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	3db5ed69d49e5d79f990aca0295ddce4c297a05c
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Erythrophagocytic_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	CPNE2 P3H2 HLA-DRA DNASE1L3 STAB1	8.34e-06	186	66	5	a0cc925af97e47efd0c9bc17c37963e8ad4e5b35
ToppCell	healthy_donor-Lymphocytic-Dendritic-pDC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	CIB2 P3H2 HLA-DRA SCN9A DNASE1L3	8.34e-06	186	66	5	45f66619e45d590c7365a51782d4ac46b7d31fde
ToppCell	Mild-Lymphoid-pDC-\|Mild / Condition, Lineage, Cell class and cell subclass	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	1d05e73ae2ec0cc27f79e4fa40d6b21790059f80
ToppCell	BAL-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.34e-06	186	66	5	79aedd5aed72509a4925e9f6cb43bc0c798c86f5
ToppCell	Mild_COVID-19-Myeloid-pDC\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.55e-06	187	66	5	99c3c4a7b9179dce7982dc6516d561c952abc80e
ToppCell	Healthy_donor-pDC\|World / disease group, cell group and cell class (v2)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.55e-06	187	66	5	aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCell	(0)_Myeloid-(011)_pDC\|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)	FMNL3 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	a81b5d840490d6a636fe168f8cff2c4984369f09
ToppCell	COVID-19_Severe-pDC-\|COVID-19_Severe / Disease condition and Cell class	FMNL3 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	9fd1116e31a05554850b8ed3c005ea660dfbd51c
ToppCell	3'_v3-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	SLC32A1 CIB2 HLA-DRA SCN9A DNASE1L3	8.78e-06	188	66	5	239a2162a21d3339da7c1884ab76286346fbf97f
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	89411c4db3df5e1dc36cf8af4ffcc0abbecbe4df
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S100B FREM2 RAD9B ELOVL2 UNC80	8.78e-06	188	66	5	c2101ded71fb16b8ddbc1f883911b1ed2a533ffc
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	26405ef1b934744e672c642db78834c21d3ba28f
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S100B FREM2 RAD9B ELOVL2 UNC80	8.78e-06	188	66	5	3b8b9161f0fdcbde302ce5b4c0bc874628211109
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	de6a270b6e4fe09c39a52c296632d86ada98465b
ToppCell	COVID-19_Mild-pDC\|COVID-19_Mild / Disease condition and Cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	62d33d2990d4a2d32bd0863147e47f656df1966e
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	879054b780378ae05be68e597c77c931bf0ade03
ToppCell	myeloid-pDC\|myeloid / Lineage and Cell class	FMNL3 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	a2dc4bbeca2bdc00c51825dd65a699c54c72f241
ToppCell	COVID-19_Mild-pDC-\|COVID-19_Mild / Disease condition and Cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	a75c2cf2f8dae343c13aaa66b637658b935ed10a
ToppCell	COVID-19_Severe-pDC\|COVID-19_Severe / Disease condition and Cell class	FMNL3 CIB2 P3H2 SCN9A DNASE1L3	8.78e-06	188	66	5	475008f45673b42b75ef231c2df91f8b9adc9201
ToppCell	PBMC-Mild-Myeloid-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.01e-06	189	66	5	209cae68d78c8f72479b169e27c3ff7e143adece
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.01e-06	189	66	5	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	PBMC-Mild-Myeloid-pDC-pDC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.01e-06	189	66	5	a9ad1fb12304541f909dd0eeac9b9eb28c31fd41
ToppCell	COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease group, lineage and cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.01e-06	189	66	5	c6cfd6aa21c19f2c62d80218bbc924e14e82aada
ToppCell	Control-Myeloid-pDC\|Control / Disease group, lineage and cell class	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.01e-06	189	66	5	46770b99da42f11f10cfc67cea8562342d60b867
ToppCell	PBMC-Mild-Myeloid-pDC-pDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.01e-06	189	66	5	98ca646231fbd5f29827c2dd31ac4503026bad7d
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.24e-06	190	66	5	adffa93635da10251f28b2089fd96b189775c8b4
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.24e-06	190	66	5	9a91bf1ea105029e6412d0d9060bca325299ce26
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.24e-06	190	66	5	39c8ddc2639bf3e986dae11fbae61a735614b604
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC32A1 CIB2 P3H2 SCN9A DNASE1L3	9.24e-06	190	66	5	2c1c079fd411c03bc3f383aa927eea9446716960
Drug	lifarizine	SCN4A GLUD1 GLUD2 SCN9A	1.40e-07	17	65	4	CID000071336
Drug	tyrosinate	MMP24 S100B GYG1 GLUD1 GLUD2 TTL ELOVL2	2.16e-07	148	65	7	CID000001153
Drug	2-heptanol	KCNH1 GLUD1 GLUD2	1.23e-06	8	65	3	CID000010976
Drug	Etanidazole [22668-01-5]; Down 200; 18.6uM; PC3; HT_HG-U133A	SEPTIN8 WDHD1 P3H2 SCN9A PPP6R2 EDRF1 CDON	1.59e-06	199	65	7	5730_DN
Drug	5'-deoxypyridoxal	GLUD1 GLUD2 PYGM	4.80e-06	12	65	3	CID000164889
Drug	AC1LCJM3	TRPV1 SCN4A SCN9A	6.22e-06	13	65	3	CID000631640
Drug	phenyltriethoxysilane	GLUD1 GLUD2	8.03e-06	2	65	2	CID000013075
Drug	methylmercuric bromide	GLUD1 GLUD2	8.03e-06	2	65	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	8.03e-06	2	65	2	CID000068137
Drug	G-3SH	GLUD1 GLUD2	8.03e-06	2	65	2	CID000174237
Drug	x 1 s	GLUD1 GLUD2	8.03e-06	2	65	2	CID000409694
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	8.03e-06	2	65	2	CID006455327
Drug	methoxyethylmercury	GLUD1 GLUD2	2.40e-05	3	65	2	CID000115155
Drug	4-methylumbelliferyl laurate	GLUD1 GLUD2	2.40e-05	3	65	2	CID000600674
Drug	methylmercuric iodide	GLUD1 GLUD2	2.40e-05	3	65	2	CID000067347
Drug	lenthionine	GLUD1 GLUD2	2.40e-05	3	65	2	CID000067521
Drug	N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide	SCN4A SCN9A	2.40e-05	3	65	2	ctd:C561228
Drug	mildiomycin	GLUD1 GLUD2	2.40e-05	3	65	2	CID000125665
Drug	CoA group	P3H2 GLUD1 BAAT GLUD2 TTL ACSM2A CDON ACSM2B	3.14e-05	433	65	8	CID000000317
Drug	methyl benzoquate	GLUD1 GLUD2	4.80e-05	4	65	2	CID000026383
Drug	8-BDB-TADP	GLUD1 GLUD2	4.80e-05	4	65	2	CID000130791
Drug	cadina-3,9-diene	GLUD1 GLUD2	4.80e-05	4	65	2	CID000010657
Drug	AC1L9CUQ	GLUD1 GLUD2	4.80e-05	4	65	2	CID000442451
Drug	AC1NUTWC	ACSM2A ACSM2B	4.80e-05	4	65	2	CID005460914
Drug	pentenoic acid	GLUD1 GLUD2	4.80e-05	4	65	2	CID000012299
Drug	alpha-ketoglutaramate	GLUD1 GLUD2	4.80e-05	4	65	2	CID000000048
Drug	luxabendazole	GLUD1 GLUD2	4.80e-05	4	65	2	CID000072019
Drug	ureidoglycine	GLUD1 GLUD2	4.80e-05	4	65	2	CID000439649
Drug	N-butylmaleimide	GLUD1 GLUD2	4.80e-05	4	65	2	CID000239780
Drug	Ivin	GLUD1 GLUD2	4.80e-05	4	65	2	CID000014083
Drug	alpha-methylglutamate	GLUD1 GLUD2	4.80e-05	4	65	2	CID000095440
Drug	2b E2	GLUD1 GLUD2	4.80e-05	4	65	2	CID005327076
Drug	nefopam	S100B SCN4A SCN9A	6.19e-05	27	65	3	CID000004450
Drug	1-pheg	GLUD1 GLUD2	7.98e-05	5	65	2	CID000152041
Drug	5'-FSBAzA	GLUD1 GLUD2	7.98e-05	5	65	2	CID000130430
Drug	adenine N1-oxide	GLUD1 GLUD2	7.98e-05	5	65	2	CID000093557
Drug	bathocuproine	GLUD1 GLUD2	7.98e-05	5	65	2	CID000065149
Drug	choline sulfate	GLUD1 GLUD2	7.98e-05	5	65	2	CID000000485
Drug	l-413	GLUD1 GLUD2	7.98e-05	5	65	2	CID000012475
Drug	AC1NRA4I	GLUD1 GLUD2	7.98e-05	5	65	2	CID005287695
Drug	isosteviol lactone	GLUD1 GLUD2	7.98e-05	5	65	2	CID000401559
Drug	3-aminopicolinate	GLUD1 GLUD2	7.98e-05	5	65	2	CID000073836
Drug	alpha-monofluoromethylputrescine	GLUD1 GLUD2	1.19e-04	6	65	2	CID000134201
Drug	dadAB	GLUD1 GLUD2	1.19e-04	6	65	2	CID000022626
Drug	N-methylhydantoin	GLUD1 GLUD2	1.19e-04	6	65	2	CID000069217
Drug	APETx1, Anthopleura elegantissima	SCN4A SCN8A	1.19e-04	6	65	2	ctd:C475726
Drug	diazonium-1-H-tetrazole	GLUD1 GLUD2	1.19e-04	6	65	2	CID000188312
Drug	AC1L448Y	GLUD1 GLUD2	1.19e-04	6	65	2	CID000200389
Drug	2-BDB-TAMP	GLUD1 GLUD2	1.19e-04	6	65	2	CID000127220
Drug	Emid	GLUD1 GLUD2	1.19e-04	6	65	2	CID000074798
Drug	dimethylmalonate	GLUD1 GLUD2	1.19e-04	6	65	2	CID000007943
Drug	AC1L8SA5	GLUD1 GLUD2	1.19e-04	6	65	2	CID000407285
Drug	2-methyl-1,2,3,4-tetrahydroisoquinoline	GLUD1 GLUD2	1.19e-04	6	65	2	CID000015362
Drug	lanosol	GLUD1 GLUD2	1.19e-04	6	65	2	CID000078659
Drug	isodiazinon	GLUD1 GLUD2	1.19e-04	6	65	2	CID000133913
Drug	sipatrigine	SLC32A1 SCN4A SCN9A	1.61e-04	37	65	3	CID000060803
Drug	carbophenothion	GLUD1 GLUD2	1.67e-04	7	65	2	CID000013081
Drug	37474A	GLUD1 GLUD2	1.67e-04	7	65	2	CID004330138
Drug	AC1L1B5W	GLUD1 GLUD2	1.67e-04	7	65	2	CID000001296
Drug	2-oxoglutaconic acid	GLUD1 GLUD2	1.67e-04	7	65	2	CID006443759
Drug	d-serine methyl ester hydrochloride	GLUD1 GLUD2	1.67e-04	7	65	2	CID000090387
Drug	6-chloroquinoxaline-2,3-diol	GLUD1 GLUD2	2.22e-04	8	65	2	CID000081143
Drug	2'(3')-O-(2,4,6-trinitrophenyl)-ADP	GLUD1 GLUD2	2.22e-04	8	65	2	CID000644359
Drug	Nessler's reagent	GLUD1 GLUD2	2.22e-04	8	65	2	CID000024542
Drug	iminoglutarate	GLUD1 GLUD2	2.22e-04	8	65	2	CID000152649
Drug	bidisomide	GLUD1 GLUD2	2.22e-04	8	65	2	CID000059798
Drug	Pheg	GLUD1 GLUD2	2.22e-04	8	65	2	CID003080746
Drug	AC1MQ2IK	GLUD1 GLUD2	2.22e-04	8	65	2	CID003394958
Drug	AC1N690Y	GLUD1 GLUD2	2.22e-04	8	65	2	CID004256264
Drug	trimethyllead chloride	GLUD1 GLUD2	2.22e-04	8	65	2	CID000223969
Drug	pyraclofos	KCNH1 GYG1 SCN4A SCN9A	2.42e-04	106	65	4	CID000093460
Drug	Nicergoline; Down 200; 8.2uM; PC3; HT_HG-U133A	CIB2 OSBPL2 PPP6R2 ELOVL2 TBC1D17	2.44e-04	196	65	5	2058_DN
Drug	genistein; Down 200; 10uM; PC3; HG-U133A	CIB2 OSBPL2 HUS1 PIGR PPP6R2	2.50e-04	197	65	5	703_DN
Drug	Saquinavir mesylate [149845-06-7]; Up 200; 5.2uM; HL60; HT_HG-U133A	CYLD TRPV1 CIB2 HUS1 ELOVL2	2.56e-04	198	65	5	6127_UP
Drug	Ticarcillin sodium [4697-14-7]; Up 200; 9.4uM; PC3; HT_HG-U133A	CIB2 OSBPL2 BAAT SCN9A TBC1D17	2.56e-04	198	65	5	5829_UP
Drug	Carteolol hydrochloride [51781-21-6]; Up 200; 12.2uM; PC3; HT_HG-U133A	MEP1B GPLD1 BAAT CDH5 STAB1	2.56e-04	198	65	5	4096_UP
Drug	Nicardipine hydrochloride [54527-84-3]; Down 200; 7.8uM; PC3; HT_HG-U133A	CYLD TRPV1 CIB2 OSBPL2 PPP6R2	2.56e-04	198	65	5	6297_DN
Drug	Prednicarbate [73771-04-7]; Up 200; 8.2uM; MCF7; HT_HG-U133A	MEP1B CYLD PIGR EDRF1 ELOVL2	2.62e-04	199	65	5	5544_UP
Drug	Iproniazide phosphate [305-33-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A	OSBPL2 HUS1 DDX54 GON4L PPP6R2	2.62e-04	199	65	5	5458_DN
Drug	Tiapride hydrochloride [51012-33-0]; Up 200; 11uM; MCF7; HT_HG-U133A	CYLD HUS1 PIGR KCNH1 DNASE1L3	2.62e-04	199	65	5	2292_UP
Drug	NHS-ASA	GLUD1 GLUD2	2.85e-04	9	65	2	CID003035647
Drug	dimethyl L-glutamate	GLUD1 GLUD2	2.85e-04	9	65	2	CID000093032
Drug	AC1L1GWH	GLUD1 GLUD2	2.85e-04	9	65	2	CID000003872
Drug	AC1N4HBY	GLUD1 GLUD2	2.85e-04	9	65	2	CID004128835
Drug	DCQX	GLUD1 GLUD2	2.85e-04	9	65	2	CID000001845
Drug	adipamide	GLUD1 GLUD2	2.85e-04	9	65	2	CID000012364
Drug	temelastine	GLUD1 GLUD2	2.85e-04	9	65	2	CID000055482
Drug	Asparagusate	GLUD1 GLUD2	2.85e-04	9	65	2	CID000016682
Drug	arvanil	TRPV1 HLA-DRA	3.56e-04	10	65	2	ctd:C121153
Drug	bis-NAD	GLUD1 GLUD2	3.56e-04	10	65	2	CID003081557
Drug	NmiQ	GLUD1 GLUD2	3.56e-04	10	65	2	CID000019850
Drug	S884	GLUD1 GLUD2	3.56e-04	10	65	2	CID004685067
Drug	diglycerol	GLUD1 GLUD2	3.56e-04	10	65	2	CID000042953
Drug	glutamate	SLC32A1 GPLD1 S100B TRPV1 MDN1 SCN4A GLUD1 GLUD2 SCN9A TTL	3.75e-04	962	65	10	CID000000611
Drug	benzoate	GPLD1 GLUD1 GLUD2 ACSM2A ACSM2B	4.24e-04	221	65	5	CID000000242
Drug	sulfoacetic acid	GLUD1 GLUD2	4.34e-04	11	65	2	CID000031257
Drug	ADP-ribosylcysteine	GLUD1 GLUD2	4.34e-04	11	65	2	CID003035804
Drug	5-ethylphenazin-5-ium	GLUD1 GLUD2	4.34e-04	11	65	2	CID000082689
Drug	RH-3421	SCN4A SCN9A	4.34e-04	11	65	2	CID000108039
Drug	chloroacetylajmaline	SCN4A SCN9A	4.34e-04	11	65	2	CID000038681
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN8A SCN9A	1.16e-06	10	64	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN8A SCN9A	1.16e-06	10	64	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN8A SCN9A	2.11e-06	12	64	3	DOID:0060170 (implicated_via_orthology)
Disease	X-21319 measurement	ACSM2A ACSM2B	4.63e-06	2	64	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	1.39e-05	3	64	2	EFO_0021242
Disease	B Virus Infection	SCN8A SCN9A	1.39e-05	3	64	2	C0037140
Disease	Postherpetic neuralgia	SCN8A SCN9A	1.39e-05	3	64	2	C0032768
Disease	Herpesviridae Infections	SCN8A SCN9A	1.39e-05	3	64	2	C0019372
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	1.39e-05	3	64	2	DOID:885 (biomarker_via_orthology)
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	4.61e-05	5	64	2	EFO_0800378
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	6.91e-05	6	64	2	DOID:1825 (biomarker_via_orthology)
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	6.91e-05	6	64	2	EFO_0800106
Disease	Epilepsy	KCNH1 GLUD1 SCN8A SCN9A	9.44e-05	109	64	4	C0014544
Disease	late onset Parkinson's disease (is_implicated_in)	HLA-DRA GLUD2	2.52e-04	11	64	2	DOID:0060892 (is_implicated_in)
Disease	epilepsy (implicated_via_orthology)	KCNH1 SCN4A SCN8A SCN9A	4.41e-04	163	64	4	DOID:1826 (implicated_via_orthology)
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	4.77e-04	15	64	2	DOID:13413 (biomarker_via_orthology)
Disease	Glycogen storage disease	GYG1 PYGM	6.17e-04	17	64	2	cv:C0017919
Disease	visual epilepsy (biomarker_via_orthology)	S100B GLUD1 GLUD2	9.99e-04	90	64	3	DOID:11832 (biomarker_via_orthology)
Disease	brain ischemia (biomarker_via_orthology)	S100B GLUD1 GLUD2	1.43e-03	102	64	3	DOID:2316 (biomarker_via_orthology)
Disease	Glycogen Storage Disease	GYG1 PYGM	1.57e-03	27	64	2	C0017919
Disease	response to tenofovir, creatinine clearance measurement	FMNL3 TRAPPC12 FGD5	1.87e-03	112	64	3	EFO_0007934, EFO_0009279
Disease	antihyperlipidemic drug use measurement	MEP1B HLA-DRA DNAH11	2.02e-03	115	64	3	EFO_0803367
Disease	temporal lobe epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	2.07e-03	31	64	2	DOID:3328 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFQASLEDENGDMFY	BAAT	31	Q14032
AFSQGEVIMDFGNTD	ADGRF3	696	Q8IZF5
GVGNADFAAMEFLDG	CPNE2	471	Q96FN4
MFEDVFSDSGNTGNF	AGAP9	1	Q5VTM2
DEDGYFQFMGRANDI	ACSM2A	451	Q08AH3
VEGFFQAIMHDLDFF	DNAH11	916	Q96DT5
QGEFTFCEDMAAQVG	CDH5	581	P33151
FVGSDEFDFFQIGMD	RAD9B	206	Q6WBX8
DGNFNTVALFRGEMF	MMP24	381	Q9Y5R2
GGNQMLDEGFVEDFS	MDN1	4491	Q9NU22
SFGMAYDFIDSVGND	EDRF1	106	Q3B7T1
NATSDMFYFAVEDGG	FREM2	1741	Q5SZK8
FDEADRLFEMGFAEQ	DDX54	246	Q8TDD1
ENDGYVDMSSFNAFE	FGD5	816	Q6ZNL6
AFENVDEVSAFMGDP	KCNH1	311	O95259
GFRIAFNMFDTDGNE	MICU3	236	Q86XE3
SALLYMNDDFEGGEF	P3H2	606	Q8IVL5
MDFFDDANLFGETLE	CHD9	6	Q3L8U1
EQGQADYMGADSFDN	GYG1	326	P46976
AENFIFMGDFNAGCS	DNASE1L3	181	Q13609
SGNLQEECEMLEGFF	GFRA3	321	O60609
AFDDEINAFLDNMFG	ELOVL2	6	Q9NXB9
EDDPNFFKMVEGFFD	GLUD1	61	P00367
MFDFEGLESGDDGAF	FMNL3	151	Q8IVF7
DIKMQCFNEGGESEF	CDON	901	Q4KMG0
CFNEGGESEFSNVMI	CDON	906	Q4KMG0
FQEQLLSFFMEDVFG	IL26	81	Q9NPH9
EELFETFQDEMGFSN	GON4L	591	Q3T8J9
TFQDEMGFSNMEDDG	GON4L	596	Q3T8J9
GFMYGNIFEDEERFQ	AGBL4	336	Q5VU57
PDQSGEFMFDFDGDE	HLA-DRA	41	P01903
MDEDLFTGDGDYQFD	HASPIN	706	Q8TF76
LFFDSMADRDGGQNG	CYLD	886	Q9NQC7
NFDVDGGMDQDIFDI	MEP1B	26	Q16820
EDDPNFFKMVEGFFD	GLUD2	61	P49448
MTANFVDQFGFNDEE	PPP6R2	571	O75170
NEEFLLFGAFFEATM	FER1L6	476	Q2WGJ9
SGADGNFMDEKFAQE	RTL1	431	A6NKG5
NEGFFLNYLFSGMDD	POLR1A	271	O95602
SGIDDMFNFETFGNS	SCN4A	1511	P35499
GEQDDFADFMAFSNS	SYNRG	686	Q9UMZ2
ENFFNEFQMEGVSAE	HUS1	61	O60921
ATGEDNDEFFMDFLQ	SCGB1C2	21	P0DMR2
KEDGINDMFNFETFG	SCN9A	1671	Q15858
LDNDGDGECDFQEFM	S100B	61	P04271
MNGEEEFFDAVTGFD	OSBPL2	1	Q9H1P3
DEDGYFQFMGRADDI	ACSM2B	451	Q68CK6
DGEGNLTFNDFVDMF	CIB2	81	O75838
GKTEQGFENMDFFTL	TRIM63	296	Q969Q1
FCGFMELVQGNFEES	TBC1D17	441	Q9HA65
MAAVDDLQFEEFGNA	YIPF1	1	Q9Y548
GSGMENGRDEEENFF	UNC80	1136	Q8N2C7
MADAFGDELFSVFEG	MTREX	1	P42285
ANVEMAEEAGEENFF	PYGM	696	P11217
AEEAGEENFFIFGMR	PYGM	701	P11217
ALAMFFQGGETENEE	SEC16A	371	O15027
FQNAEMEFEPFGNLD	TRAPPC12	441	Q8WVT3
FTIGMGDLEFTENYD	TRPV1	641	Q8NER1
LFDGDDMSNAGDFLN	WDHD1	326	O75717
MDAGFFRGTSAEQDN	SRRM1	1	Q8IYB3
EQFQEYFLGGLDDMA	GPLD1	241	P80108
GIDDMFNFETFGNSM	SCN8A	1681	Q9UQD0
EEMGFQDSDGDSQPF	SEPTIN8	306	Q92599
MGFGFSAFQAEDDAD	STAB1	2506	Q9NY15
ATGEDNDEFFMDFLQ	SCGB1C1	21	Q8TD33
FENSREFGANDNMGA	PIGR	686	P01833
DENLSGFSDFTENMG	ZSWIM6	651	Q9HCJ5
MGFQAATDEEAVGFA	SLC32A1	31	Q9H598
SFQLFGFDFMVDEEL	TTL	311	Q8NG68