Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	abnormal kidney morphology	STK36 TAGAP ELP1 PORCN CUL9 ACSS2 CHRND ZNF503 PIKFYVE KCNH6 MET FBLN1 ALMS1 PTPRO AGXT LRP4 POLR1B C4A C4B SIGLEC1 MARVELD2 KIF13A DNAH11	1.19e-05	1363	90	23	MP:0002135
Domain	ANATO	FBLN1 C4A C4B	7.82e-06	7	115	3	SM00104
Domain	ANAPHYLATOXIN_2	FBLN1 C4A C4B	7.82e-06	7	115	3	PS01178
Domain	ANAPHYLATOXIN_1	FBLN1 C4A C4B	7.82e-06	7	115	3	PS01177
Domain	ANATO	FBLN1 C4A C4B	7.82e-06	7	115	3	PF01821
Domain	Anaphylatoxin/fibulin	FBLN1 C4A C4B	7.82e-06	7	115	3	IPR000020
Domain	Tscrpt_rep_NocA-like	ZNF703 ZNF503	3.76e-05	2	115	2	IPR022129
Domain	nlz1	ZNF703 ZNF503	3.76e-05	2	115	2	PF12402
Domain	EGF_1	MASP1 MUC12 ITGB4 FBLN1 HEG1 TENM3 LRP4 MUC4	1.82e-04	255	115	8	PS00022
Domain	EGF-like_CS	MASP1 MUC12 ITGB4 FBLN1 HEG1 TENM3 LRP4 MUC4	2.13e-04	261	115	8	IPR013032
Domain	EGF_2	MASP1 MUC12 ITGB4 FBLN1 HEG1 TENM3 LRP4 MUC4	2.36e-04	265	115	8	PS01186
Domain	AA_TRANSFER_CLASS_5	SCLY AGXT	3.71e-04	5	115	2	PS00595
Domain	Anaphylatoxin_comp_syst	C4A C4B	3.71e-04	5	115	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	3.71e-04	5	115	2	IPR001840
Domain	Aminotrans_V_dom	SCLY AGXT	5.55e-04	6	115	2	IPR000192
Domain	Aminotran_5	SCLY AGXT	5.55e-04	6	115	2	PF00266
Domain	ZINC_FINGER_C2H2_2	ZNF703 ZNF93 ZNF143 ZNF596 ZNF813 ZNF571 ZNF280B ZBTB41 ZNF442 ZNF440 ZNF503 ZNF462 ZNF20	9.67e-04	775	115	13	PS50157
Domain	-	ZNF703 ZNF93 ZNF143 ZNF596 ZNF813 ZNF571 ZBTB41 ZNF442 ZNF440 ZNF503 ZNF462 ZNF20	9.77e-04	679	115	12	3.30.160.60
Domain	ZINC_FINGER_C2H2_1	ZNF703 ZNF93 ZNF143 ZNF596 ZNF813 ZNF571 ZNF280B ZBTB41 ZNF442 ZNF440 ZNF503 ZNF462 ZNF20	9.90e-04	777	115	13	PS00028
Domain	FN3	PAPPA2 KALRN ITGB4 FANK1 PTPRO SDK1	1.00e-03	185	115	6	SM00060
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.03e-03	8	115	2	IPR019565
Domain	Calx_beta	FREM3 ITGB4	1.03e-03	8	115	2	SM00237
Domain	Thiol-ester_cl	C4A C4B	1.03e-03	8	115	2	PF10569
Domain	MacrogloblnA2_CS	C4A C4B	1.03e-03	8	115	2	IPR019742
Domain	Znf_C2H2/integrase_DNA-bd	ZNF703 ZNF93 ZNF143 ZNF596 ZNF813 ZNF571 ZBTB41 ZNF442 ZNF440 ZNF503 ZNF462 ZNF20	1.18e-03	694	115	12	IPR013087
Domain	Znf_C2H2-like	ZNF703 ZNF93 ZNF143 ZNF596 ZNF813 ZNF571 ZNF280B ZBTB41 ZNF442 ZNF440 ZNF503 ZNF462 ZNF20	1.23e-03	796	115	13	IPR015880
Domain	-	GAD2 SCLY AGXT	1.29e-03	35	115	3	3.90.1150.10
Domain	Calx_beta	FREM3 ITGB4	1.32e-03	9	115	2	IPR003644
Domain	Calx-beta	FREM3 ITGB4	1.32e-03	9	115	2	PF03160
Domain	Znf_C2H2	ZNF703 ZNF93 ZNF143 ZNF596 ZNF813 ZNF571 ZNF280B ZBTB41 ZNF442 ZNF440 ZNF503 ZNF462 ZNF20	1.36e-03	805	115	13	IPR007087
Domain	PyrdxlP-dep_Trfase_major_sub2	GAD2 SCLY AGXT	1.40e-03	36	115	3	IPR015422
Domain	ZnF_C2H2	ZNF703 ZNF93 ZNF143 ZNF596 ZNF813 ZNF571 ZNF280B ZBTB41 ZNF442 ZNF440 ZNF503 ZNF462 ZNF20	1.41e-03	808	115	13	SM00355
Domain	A2M	C4A C4B	1.64e-03	10	115	2	PF00207
Domain	A2M_N_2	C4A C4B	1.64e-03	10	115	2	IPR011625
Domain	A2M_comp	C4A C4B	1.64e-03	10	115	2	IPR011626
Domain	A2M_recep	C4A C4B	1.64e-03	10	115	2	PF07677
Domain	A2M_comp	C4A C4B	1.64e-03	10	115	2	PF07678
Domain	A2M_N	C4A C4B	1.64e-03	10	115	2	PF01835
Domain	A2M_N	C4A C4B	1.64e-03	10	115	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.64e-03	10	115	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.64e-03	10	115	2	PS00477
Domain	A2M_N_2	C4A C4B	1.64e-03	10	115	2	PF07703
Domain	Macroglobln_a2	C4A C4B	1.64e-03	10	115	2	IPR001599
Domain	-	GAD2 SCLY AGXT	1.77e-03	39	115	3	3.40.640.10
Domain	-	ELP1 TENM3 LRP4	1.77e-03	39	115	3	2.120.10.30
Domain	FN3_dom	PAPPA2 KALRN ITGB4 FANK1 PTPRO SDK1	1.87e-03	209	115	6	IPR003961
Domain	EGF_CA	MASP1 FBLN1 HEG1 LRP4	1.96e-03	86	115	4	PF07645
Domain	PyrdxlP-dep_Trfase	GAD2 SCLY AGXT	2.04e-03	41	115	3	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	GAD2 SCLY AGXT	2.04e-03	41	115	3	IPR015421
Domain	6-blade_b-propeller_TolB-like	ELP1 TENM3 LRP4	2.85e-03	46	115	3	IPR011042
Domain	EGF_Ca-bd_CS	MASP1 FBLN1 HEG1 LRP4	3.04e-03	97	115	4	IPR018097
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH11	3.26e-03	14	115	2	IPR011704
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 KCNH6	3.26e-03	14	115	2	IPR003938
Domain	AAA_5	MDN1 DNAH11	3.26e-03	14	115	2	PF07728
Domain	EGF_CA	MASP1 FBLN1 HEG1 LRP4	3.28e-03	99	115	4	PS01187
Domain	zf-C2H2_6	ZNF93 ZNF813 ZNF571 ZBTB41 ZNF442 ZNF440 ZNF20	3.31e-03	314	115	7	PF13912
Domain	EGF_3	MASP1 FBLN1 HEG1 TENM3 LRP4 MUC4	3.35e-03	235	115	6	PS50026
Domain	ASX_HYDROXYL	MASP1 FBLN1 HEG1 LRP4	3.40e-03	100	115	4	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	MASP1 FBLN1 HEG1 LRP4	4.18e-03	106	115	4	IPR000152
Domain	VWF_type-D	MUC5B MUC4	4.26e-03	16	115	2	IPR001846
Domain	VWFD	MUC5B MUC4	4.26e-03	16	115	2	PS51233
Domain	VWD	MUC5B MUC4	4.26e-03	16	115	2	SM00216
Domain	VWD	MUC5B MUC4	4.26e-03	16	115	2	PF00094
Domain	EGF-like_dom	MASP1 FBLN1 HEG1 TENM3 LRP4 MUC4	4.44e-03	249	115	6	IPR000742
Domain	C345C	C4A C4B	4.81e-03	17	115	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	5.39e-03	18	115	2	IPR008930
Domain	NTR	C4A C4B	6.00e-03	19	115	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	6.00e-03	19	115	2	IPR018933
Domain	Fd_Rdtase_FAD-bd	DUOX1 NOS2	6.00e-03	19	115	2	IPR017927
Domain	FAD_FR	DUOX1 NOS2	6.00e-03	19	115	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX1 NOS2	6.00e-03	19	115	2	IPR017938
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC16 MUC5B MUC12 MUC4	2.22e-06	16	86	4	M27410
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC16 MUC5B MUC12 MUC4	2.89e-06	17	86	4	M27412
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC16 MUC5B MUC12 MUC4	1.05e-05	23	86	4	M556
Pathway	REACTOME_DECTIN_2_FAMILY	MUC16 MUC5B MUC12 MUC4	1.74e-05	26	86	4	M27483
Pathway	WP_SIDS_SUSCEPTIBILITY_PATHWAYS	RYR2 SLC6A4 C4A C4B TNF	2.90e-05	59	86	5	MM15838
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	MASP1 C4A C4B	3.49e-05	11	86	3	M47874
Pathway	BIOCARTA_LECTIN_PATHWAY	MASP1 C4A C4B	3.49e-05	11	86	3	MM1430
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	THSD4 MUC16 MUC5B MUC12 MUC4	5.79e-05	68	86	5	M27303
Pathway	BIOCARTA_LECTIN_PATHWAY	MASP1 C4A C4B	6.00e-05	13	86	3	M4732
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	MASP1 C4A C4B	1.40e-04	17	86	3	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	MASP1 C4A C4B	1.40e-04	17	86	3	MM1369
Pathway	BIOCARTA_COMP_PATHWAY	MASP1 C4A C4B	2.32e-04	20	86	3	M917
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	THSD4 MUC16 MUC5B MUC12 MUC4 MAN1B1	2.37e-04	143	86	6	M27275
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC16 MUC5B MUC4	2.69e-04	21	86	3	MM15706
Pathway	WP_COMPLEMENT_ACTIVATION	MASP1 C4A C4B	3.10e-04	22	86	3	M39502
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	MUC16 MUC5B MUC12 MUC4	5.50e-04	62	86	4	M546
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD4 MUC16 MUC5B MUC12 MUC4	5.80e-04	111	86	5	M27416
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	7.57e-04	7	86	2	MM14685
Pathway	REACTOME_DISEASES_OF_METABOLISM	THSD4 SFTA3 MUC16 MUC5B MUC12 MUC4 MAN1B1	8.28e-04	250	86	7	M27554
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKRD13D STK36 FOXK2 KALRN INPPL1 UBE3B CUL9 PFAS MLXIP ITGB4 ZNF503 PIKFYVE HEG1 C2CD3 MDN1 C19orf44 LRP4 PCNX1	5.54e-08	1105	121	18	35748872
Pubmed	Toward a structure-based comprehension of the lectin pathway of complement.	MASP1 C4A C4B	4.09e-07	5	121	3	23911397
Pubmed	Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D.	MASP1 C4A C4B	4.09e-07	5	121	3	20038603
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC16 MUC5B MUC12 MUC4	4.11e-07	18	121	4	18834073
Pubmed	Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis.	MASP1 C4A C4B	2.27e-06	8	121	3	20870940
Pubmed	Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.	NDST2 C4A C4B	3.40e-06	9	121	3	15905575
Pubmed	HLA-association of serum levels of natural antibodies.	C4A C4B TNF	4.84e-06	10	121	3	19167759
Pubmed	Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.	MASP1 C4A C4B	4.84e-06	10	121	3	21943708
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	INPPL1 BRSK2 MLXIP FAM171A1 C2CD3 MDN1 ALMS1 PLEKHA3 SSH2 KIF13A UTRN PCM1 SAMD4A	1.01e-05	861	121	13	36931259
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.20e-05	2	121	2	19062096
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.20e-05	2	121	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.20e-05	2	121	2	12207352
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.20e-05	2	121	2	27758680
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.20e-05	2	121	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.20e-05	2	121	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.20e-05	2	121	2	4216347
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.20e-05	2	121	2	8428773
Pubmed	Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia.	SLC6A4 TNF	1.20e-05	2	121	2	23305936
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.20e-05	2	121	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.20e-05	2	121	2	21345967
Pubmed	The complement component C4 of mammals.	C4A C4B	1.20e-05	2	121	2	2302180
Pubmed	Phenotype/Genotype Relationship in Left Ventricular Noncompaction: Ion Channel Gene Mutations Are Associated With Preserved Left Ventricular Systolic Function and Biventricular Noncompaction: Phenotype/Genotype of Noncompaction.	HCN4 RYR2	1.20e-05	2	121	2	34088380
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.20e-05	2	121	2	22151770
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.20e-05	2	121	2	29080553
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.20e-05	2	121	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.20e-05	2	121	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.20e-05	2	121	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.20e-05	2	121	2	6149581
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.20e-05	2	121	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.20e-05	2	121	2	2387317
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.20e-05	2	121	2	7365238
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.20e-05	2	121	2	17971360
Pubmed	Undetectable levels of tumor necrosis factor-alpha, nitric oxide and inadequate expression of inducible nitric oxide synthase in congenital hypothyroidism.	TNF NOS2	1.20e-05	2	121	2	12799216
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.20e-05	2	121	2	17971229
Pubmed	Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.	BID MTCH2	1.20e-05	2	121	2	15899861
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.20e-05	2	121	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.20e-05	2	121	2	28873507
Pubmed	Expression of mucins in mucoid otitis media.	MUC5B MUC4	1.20e-05	2	121	2	14690056
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	1.20e-05	2	121	2	3794341
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	1.20e-05	2	121	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	1.20e-05	2	121	2	32691186
Pubmed	Labile anger during interferon alfa treatment is associated with a polymorphism in tumor necrosis factor alpha.	SLC6A4 TNF	1.20e-05	2	121	2	20661026
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	1.20e-05	2	121	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	1.20e-05	2	121	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.20e-05	2	121	2	7373044
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.20e-05	2	121	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.20e-05	2	121	2	16098595
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.20e-05	2	121	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.20e-05	2	121	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.20e-05	2	121	2	6559257
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.20e-05	2	121	2	12480675
Pubmed	TNFα-dependent anhedonia and upregulation of hippocampal serotonin transporter activity in a mouse model of collagen-induced arthritis.	SLC6A4 TNF	1.20e-05	2	121	2	29723540
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.20e-05	2	121	2	26800705
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.20e-05	2	121	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.20e-05	2	121	2	2997024
Pubmed	TNF-α promotes invasive growth through the MET signaling pathway.	MET TNF	1.20e-05	2	121	2	25306394
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.20e-05	2	121	2	3624865
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.20e-05	2	121	2	30041577
Pubmed	A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.	ITGB4 MET	1.20e-05	2	121	2	11733063
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.20e-05	2	121	2	3862104
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	1.20e-05	2	121	2	26814963
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	1.20e-05	2	121	2	8132550
Pubmed	SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.	BRSK2 BRSK1	1.20e-05	2	121	2	16630837
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	1.20e-05	2	121	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	1.20e-05	2	121	2	26814708
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	1.20e-05	2	121	2	1438267
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	1.20e-05	2	121	2	19150565
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	1.20e-05	2	121	2	17506029
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	1.20e-05	2	121	2	23715124
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	1.20e-05	2	121	2	2993295
Pubmed	B-vitamin deficiency is protective against DSS-induced colitis in mice.	TNF NOS2	1.20e-05	2	121	2	21596995
Pubmed	TNFA locus is associated with beta degrees 39 thalassemia in Corsica and Sardinia.	TNF NOS2	1.20e-05	2	121	2	19103526
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	1.20e-05	2	121	2	33353966
Pubmed	Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha expression by 4-nonylphenol in macrophages.	TNF NOS2	1.20e-05	2	121	2	12061770
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	1.20e-05	2	121	2	2900855
Pubmed	Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.	C4A C4B	1.20e-05	2	121	2	23259761
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.20e-05	2	121	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.20e-05	2	121	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.20e-05	2	121	2	15998580
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.20e-05	2	121	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.20e-05	2	121	2	2459207
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.20e-05	2	121	2	22387014
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.20e-05	2	121	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.20e-05	2	121	2	23918728
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.20e-05	2	121	2	6950384
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.20e-05	2	121	2	8660986
Pubmed	UVB radiation-mediated expression of inducible nitric oxide synthase activity and the augmenting role of co-induced TNF-alpha in human skin endothelial cells.	TNF NOS2	1.20e-05	2	121	2	15482484
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.20e-05	2	121	2	2572548
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.20e-05	2	121	2	18091514
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.20e-05	2	121	2	6589636
Pubmed	Histo- and immunocytochemical detection of inducible NOS and TNF-alpha in the locus coeruleus of human opiate addicts.	TNF NOS2	1.20e-05	2	121	2	19038328
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.20e-05	2	121	2	12115608
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.20e-05	2	121	2	16908004
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.20e-05	2	121	2	7391573
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.20e-05	2	121	2	29928053
Pubmed	TNF-alpha mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis.	TNF NOS2	1.20e-05	2	121	2	12884305
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.20e-05	2	121	2	6881182
Pubmed	Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology.	MUC16 MUC4	1.20e-05	2	121	2	23544943
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.20e-05	2	121	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.20e-05	2	121	2	21880985
GeneFamily	CD molecules\|Mucins	MUC16 MUC5B MUC12 MUC4	2.11e-06	21	81	4	648
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF93 ZNF143 ZNF596 ZNF813 ZNF571 ZBTB41 ZNF442 ZNF440 ZNF503 ZNF462 ZNF20	3.46e-04	718	81	11	28
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	6.99e-04	9	81	2	1234
GeneFamily	Fibronectin type III domain containing	KALRN ITGB4 FANK1 PTPRO SDK1	7.60e-04	160	81	5	555
Coexpression	GSE17721_LPS_VS_CPG_1H_BMDC_DN	KALRN CUL9 ACSS2 AGXT TNF KIF13A CDC27 UTRN	4.04e-06	200	120	8	M3987
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KALRN MLXIP RYR2 FRMD4A TENM3 PLEKHH2 SDK1 SAMD4A	5.44e-08	191	121	8	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	15-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	MUC16 RFX3 ZNF440 DUOX1 FANK1 MUC4 CDHR4 DNAH11	5.66e-08	192	121	8	9cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCell	Ciliated_cells-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 MUC5B RFX3 TMEM232 MUC4 CDHR4 DNAH11	7.27e-07	184	121	7	07c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	THSD4 SFTA3 ACSS2 MET DUOX1 MUC4 SDK1	7.54e-07	185	121	7	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MASP1 ZNF462 MET PTPRO KCTD16 SDK1 SAMD4A	7.82e-07	186	121	7	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RYR2 FRMD4A FBLN1 TENM3 PLEKHH2 SDK1 SAMD4A	9.02e-07	190	121	7	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 RYR2 FBLN1 LRP4 LGR6 PLEKHH2 SDK1	9.34e-07	191	121	7	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MUC16 DUOX1 FANK1 TMEM232 MUC4 CDHR4 DNAH11	1.04e-06	194	121	7	756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 RFX3 ZNF440 FANK1 MUC4 CDHR4 DNAH11	1.04e-06	194	121	7	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	MUC5B FANK1 TMEM232 MUC4 SDK1 CDHR4 DNAH11	1.07e-06	195	121	7	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 RFX3 ZNF440 FANK1 MUC4 CDHR4 DNAH11	1.07e-06	195	121	7	79dc031258579ea328181dda33710dd897f1064a
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 MUC5B RFX3 FANK1 TMEM232 CDHR4 DNAH11	1.07e-06	195	121	7	9651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|COVID-19 / Condition, Lineage and Cell class	MUC16 MUC5B ITGB4 MET MUC4 NOS2 SDK1	1.11e-06	196	121	7	dd32046067d93b9484cfbf1d7826a436a3d9f0e9
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	MET FANK1 TMEM232 MUC4 SDK1 CDHR4 DNAH11	1.11e-06	196	121	7	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	MET FANK1 TMEM232 MUC4 SDK1 CDHR4 DNAH11	1.11e-06	196	121	7	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	COVID-19-Epithelial\|COVID-19 / Condition, Lineage and Cell class	MUC16 MET DUOX1 FANK1 MUC4 CDHR4 DNAH11	1.15e-06	197	121	7	18fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KALRN RYR2 MEST FBLN1 TENM3 PLEKHH2 SAMD4A	1.19e-06	198	121	7	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	MUC16 MET FANK1 TMEM232 CDHR4 DNAH11	3.62e-06	151	121	6	8216462e723fec2797387929dde095370947e10a
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PCDHB3 RYR2 TMEM62 RLIM PLEKHH2 CDHR4	6.68e-06	168	121	6	c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	H6PD FBLN1 KIAA1549L LRP4 C4A C4B	6.68e-06	168	121	6	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PCDHB3 RYR2 TMEM62 RLIM PLEKHH2 CDHR4	6.68e-06	168	121	6	83b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 RFX3 ZNF440 FANK1 CDHR4 DNAH11	6.91e-06	169	121	6	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-5\|TCGA-Pancreas / Sample_Type by Project: Shred V9	BEAN1 PORCN MUC16 ITGB4 MET MUC4	8.16e-06	174	121	6	73e1ad4007d94fca25ed7c6fbe5d205d4e1b8a3b
ToppCell	Adult-Endothelial-endothelial_cell_of_vein\|Adult / Lineage, Cell type, age group and donor	KALRN PCDHB3 ITGB4 SLC6A4 FAM171A1 HEG1	8.71e-06	176	121	6	043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STK36 ZNF440 FANK1 MUC4 CDHR4 DNAH11	9.29e-06	178	121	6	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF703 GAD2 HCN4 RFX3 KCNH6 AGXT	9.90e-06	180	121	6	d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCell	Endothelial-A-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	MASP1 SLC6A4 FAM171A1 HEG1 CEACAM20 NOS2	9.90e-06	180	121	6	4c3376169770ee9f9283daae44c17f35e46bfd19
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MASP1 KALRN ITGB4 SLC6A4 FAM171A1 HEG1	9.90e-06	180	121	6	27e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell	COPD-Epithelial-Basal\|World / Disease state, Lineage and Cell class	SFTA3 OVCH2 ITGB4 MET MUC4 SDK1	1.02e-05	181	121	6	6d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAL3ST4 ZNF462 LRP4 PLEKHH2 KIF13A DNAH11	1.05e-05	182	121	6	a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAL3ST4 ZNF462 LRP4 PLEKHH2 KIF13A DNAH11	1.05e-05	182	121	6	831b5ce46b41efe01c4db6016c2f43148611373d
ToppCell	COPD-Epithelial-Basal\|COPD / Disease state, Lineage and Cell class	SFTA3 OVCH2 ITGB4 MET MUC4 SDK1	1.09e-05	183	121	6	0f760e393edc91009bf6c7e02eeac039a1dfb4ed
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 KALRN MUC5B RYR2 SDK1 DNAH11	1.12e-05	184	121	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 KALRN MUC5B RYR2 SDK1 DNAH11	1.12e-05	184	121	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 KALRN MUC5B RYR2 SDK1 DNAH11	1.12e-05	184	121	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	5'-Adult-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF703 MUC5B MLXIP FAM171A1 PTPRO MUC4	1.16e-05	185	121	6	655a9357a7711cefb48395e0b2a5a0ab90bcf3f5
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAL3ST4 ZNF462 LRP4 PLEKHH2 KIF13A DNAH11	1.16e-05	185	121	6	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	Ciliated_cells-B-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 RFX3 FANK1 TMEM232 CDHR4 DNAH11	1.16e-05	185	121	6	f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GAL3ST4 ZNF462 LRP4 PLEKHH2 KIF13A DNAH11	1.16e-05	185	121	6	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 KALRN RYR2 FRMD4A LGR6 SDK1	1.19e-05	186	121	6	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KALRN PCDHB3 ITGB4 SLC6A4 FAM171A1 HEG1	1.23e-05	187	121	6	e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.23e-05	187	121	6	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	RYR2 MEST FBLN1 KCTD16 PLEKHH2 SDK1	1.23e-05	187	121	6	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	multiciliated\|World / shred by cell class for bronchial biopsy	MUC12 RFX3 FANK1 TMEM232 CDHR4 DNAH11	1.27e-05	188	121	6	6833c1f0f265ef5448fa65033550ed7efc2f8d7b
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	THSD4 SFTA3 MET DUOX1 MUC4 DNAH11	1.27e-05	188	121	6	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	RFX3 ZNF440 FANK1 TMEM232 CDHR4 DNAH11	1.31e-05	189	121	6	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 KALRN MDN1 TENM3 NUP153 SAMD4A	1.35e-05	190	121	6	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	Epithelial_cells-Ciliated_cells-A\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	RFX3 FANK1 TMEM232 MUC4 CDHR4 DNAH11	1.35e-05	190	121	6	549d813a8f23b175875e53347928941f143e236c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 KALRN MDN1 TENM3 NUP153 SAMD4A	1.35e-05	190	121	6	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	COPD-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	RFX3 ZNF462 FAM171A1 HEG1 LRP4 TPSG1	1.35e-05	190	121	6	379dbac19110b76079a7a53209569e060a852acb
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.35e-05	190	121	6	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MUC16 FANK1 TMEM232 MUC4 CDHR4 DNAH11	1.39e-05	191	121	6	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MUC16 FANK1 TMEM232 MUC4 CDHR4 DNAH11	1.39e-05	191	121	6	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.39e-05	191	121	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MUC16 FANK1 TMEM232 MUC4 CDHR4 DNAH11	1.39e-05	191	121	6	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.43e-05	192	121	6	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	MUC16 FANK1 TMEM232 MUC4 CDHR4 DNAH11	1.43e-05	192	121	6	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAPPA2 FREM3 FBLN1 KCTD16 LGR6 BRSK1	1.47e-05	193	121	6	2b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	ZBTB41 TRAPPC10 POLR1B PCNX1 MARVELD2 UTRN	1.47e-05	193	121	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MET SSH2 PLEKHH2 SDK1 SAMD4A	1.47e-05	193	121	6	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAPPA2 FREM3 FBLN1 KCTD16 LGR6 BRSK1	1.47e-05	193	121	6	90cfc34c2d0d7c70f071703d35db1d6037961481
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MET SSH2 PLEKHH2 SDK1 SAMD4A	1.47e-05	193	121	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KALRN RYR2 FRMD4A FBLN1 PLEKHH2 SDK1	1.51e-05	194	121	6	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MUC12 RFX3 ZNF440 DUOX1 ALMS1 PCM1	1.51e-05	194	121	6	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	COVID-19-Epithelial-Ciliated_cells\|COVID-19 / Condition, Lineage and Cell class	MUC16 FANK1 TMEM232 MUC4 CDHR4 DNAH11	1.51e-05	194	121	6	43be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MET SSH2 PLEKHH2 SDK1 SAMD4A	1.56e-05	195	121	6	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CHRND MEST FBLN1 KIAA1549L TENM3 LRP4	1.56e-05	195	121	6	ec12cfb2fce44cc2de4e198ef5af075e626f0329
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 MET SSH2 PLEKHH2 SDK1 SAMD4A	1.56e-05	195	121	6	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RFX3 ZNF440 FANK1 TMEM232 CDHR4 DNAH11	1.56e-05	195	121	6	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 MET DUOX1 MUC4 NOS2 SDK1	1.61e-05	196	121	6	b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 MET DUOX1 MUC4 NOS2 SDK1	1.61e-05	196	121	6	c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	FANK1 TMEM232 MUC4 SDK1 CDHR4 DNAH11	1.61e-05	196	121	6	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 RFX3 FANK1 MUC4 PCM1 DNAH11	1.65e-05	197	121	6	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	KALRN RYR2 FBLN1 TENM3 PLEKHH2 SDK1	1.65e-05	197	121	6	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 RFX3 FANK1 MUC4 PCM1 DNAH11	1.65e-05	197	121	6	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 RFX3 FANK1 MUC4 PCM1 DNAH11	1.65e-05	197	121	6	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 RFX3 FANK1 MUC4 PCM1 DNAH11	1.65e-05	197	121	6	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RFX3 ZNF440 FANK1 TMEM232 CDHR4 DNAH11	1.70e-05	198	121	6	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MET DUOX1 LGR6 MUC4 NOS2 SDK1	1.70e-05	198	121	6	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	Fetal_29-31_weeks\|World / Lineage, Cell type, age group and donor	KALRN RYR2 FAM171A1 MEST FBLN1 PLEKHH2	1.75e-05	199	121	6	5b9d355795dd03a22f0961dfd143425c367a4654
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGB4 MET DUOX1 LGR6 MUC4 SDK1	1.75e-05	199	121	6	94a7867e800df352731796de8c24cba133c29622
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	RYR2 MEST FBLN1 TENM3 PLEKHH2 SDK1	1.75e-05	199	121	6	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	RYR2 FRMD4A FBLN1 TENM3 PLEKHH2 SDK1	1.75e-05	199	121	6	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Biopsy_IPF-Epithelial-Differentiating_Ciliated\|Biopsy_IPF / Sample group, Lineage and Cell type	MUC5B RFX3 FANK1 MUC4 CDHR4 DNAH11	1.80e-05	200	121	6	8dfce65e417d6dcacb871d93d1539cdf807002fe
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 FBLN1 TENM3 PLEKHH2 SDK1 SAMD4A	1.80e-05	200	121	6	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.80e-05	200	121	6	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.80e-05	200	121	6	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.80e-05	200	121	6	cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCell	Biopsy_IPF-Epithelial\|Biopsy_IPF / Sample group, Lineage and Cell type	SFTA3 DUOX1 FANK1 MUC4 CDHR4 DNAH11	1.80e-05	200	121	6	76f1ac00b34d07057d8da03d276438b719b46b1d
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.80e-05	200	121	6	311fab076f2ceb258e3970eb21e39344b894042a
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 FBLN1 TENM3 KCTD16 PLEKHH2 SDK1	1.80e-05	200	121	6	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD13D CUL9 C4A C4B STX16	2.17e-05	123	121	5	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Smooth_Muscle-like_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	MET KCTD16 LGR6 TPSG1 SAMD4A	4.04e-05	140	121	5	5623a0a68403fc00166b7d13d13e184a718d9bdd
ToppCell	PBMC-Control-cDC_2\|Control / Compartment, Disease Groups and Clusters	MUC16 ZNF462 FANK1 BRSK1 SDK1	6.16e-05	153	121	5	4ee37266b0054f276c7a73ab9220f681b9d74c71
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MUC16 MUC5B MET MUC4 SDK1	7.84e-05	161	121	5	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HCN4 ZNF813 RFX3 KCNH6 AGXT	8.81e-05	165	121	5	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_large-bowel / Manually curated celltypes from each tissue	ZBTB41 DUOX1 MARVELD2 LGR6 NOS2	9.06e-05	166	121	5	13bef304ea3df8e8d2bc376a3287c78220a1b0c6
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	THSD4 MCPH1 HCN4 FANK1 ALMS1	9.59e-05	168	121	5	c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCell	NS-critical-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MUC5B ITGB4 MET MUC4 SDK1	9.86e-05	169	121	5	aec97583b23112060437b619cb429dc32f29285f
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STK36 RFX3 TMEM232 CDHR4 DNAH11	1.10e-04	173	121	5	c3762655caa79ac4879876f470d32578a3c93b01
Drug	PHA-00851261E [724719-49-7]; Up 200; 10uM; PC3; HT_HG-U133A	PAPPA2 HCN4 CUL9 SCLY MET LRP4 TPSG1 NOS2	9.52e-06	199	118	8	4330_UP
Drug	1,2-Dimethylhydrazine	SLC6A4 MET TNF NOS2	2.20e-05	32	118	4	ctd:D019813
Drug	JBT-3002	TNF NOS2	2.66e-05	2	118	2	ctd:C112524
Drug	7-(2-(4-(4-nitrobenzene)piperazinyl)ethyl)-1,3-dimethylxanthine	TNF NOS2	2.66e-05	2	118	2	ctd:C508169
Drug	perhydrodiazepine	SLC6A4 NOS2	2.66e-05	2	118	2	CID012680363
Drug	4-dimethylamino-3',4'-dimethoxychalcone	TNF NOS2	2.66e-05	2	118	2	ctd:C418965
Drug	20(S)-Propanaxidiol	RBL2 C4A NOS2	3.74e-05	13	118	3	CID005317623
Drug	Roxithromycin	ITGB4 TNF NOS2	4.74e-05	14	118	3	ctd:D015575
Drug	Methyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; PC3; HT_HG-U133A	MUC5B KCNH6 HEG1 PTPRO AGXT MUC4 SAMD4A	5.33e-05	186	118	7	3768_UP
Drug	Gabazine [105538-73-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A	PAPPA2 XRCC4 FRMD4A FBLN1 ALMS1 PCNX1 SAMD4A	6.10e-05	190	118	7	3253_DN
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	MUC16 MLXIP ITGB4 RYR2 FAM171A1 MET DUOX1	6.51e-05	192	118	7	7489_UP
Drug	Cephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A	PAPPA2 XRCC4 FRMD4A FBLN1 ALMS1 PCNX1 PCM1	6.73e-05	193	118	7	3258_DN
Drug	Carbetapentane citrate [23142-01-0]; Up 200; 7.6uM; MCF7; HT_HG-U133A	PAPPA2 SCLY XRCC4 RYR2 CHRND KIF13A MUC4	6.95e-05	194	118	7	5610_UP
Drug	Nifurtimox [23256-30-6]; Up 200; 14uM; MCF7; HT_HG-U133A	BRSK2 ELP1 ZNF442 ZNF20 MUC4 UTRN PCM1	7.41e-05	196	118	7	7328_UP
Drug	Naloxone hydrochloride [357-08-4]; Up 200; 11uM; MCF7; HT_HG-U133A	PAPPA2 MUC5B SCLY XRCC4 ITGB4 LRP4 KIF13A	7.41e-05	196	118	7	5606_UP
Drug	Ganciclovir [82410-32-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A	GAD2 KALRN CUL9 ZNF571 FRMD4A HEG1 TPSG1	7.41e-05	196	118	7	3368_UP
Drug	Colistin sulfate [1264-72-8]; Up 200; 3uM; MCF7; HT_HG-U133A	GAD2 FRMD4A FBLN1 TMEM62 EHHADH UTRN PCM1	7.41e-05	196	118	7	2851_UP
Drug	Riboflavine [83-88-5]; Down 200; 10.6uM; PC3; HT_HG-U133A	GAL3ST4 FRMD4A FBLN1 HEG1 TENM3 UTRN PCM1	7.65e-05	197	118	7	4485_DN
Drug	Lidoflazine [3416-26-0]; Up 200; 8.2uM; MCF7; HT_HG-U133A	GAD2 HCN4 MUC5B XRCC4 DUOX1 HEG1 SAMD4A	7.65e-05	197	118	7	3201_UP
Drug	Bephenium hydroxynaphthoate [3818-50-6]; Up 200; 9uM; PC3; HT_HG-U133A	ELP1 ZNF280B RYR2 FBLN1 DUOX1 AGXT PCNX1	7.65e-05	197	118	7	4668_UP
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Up 200; 11uM; MCF7; HT_HG-U133A	CUL9 MUC5B H6PD XRCC4 DUOX1 HEG1 PCNX1	7.90e-05	198	118	7	3237_UP
Drug	pioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A	PAPPA2 NDST2 SCLY H6PD RYR2 LRP4 RASGRP2	7.90e-05	198	118	7	5972_DN
Drug	rosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	PAPPA2 ZNF571 ITGB4 RYR2 ZNF20 PCNX1 SAMD4A	7.90e-05	198	118	7	6992_UP
Drug	Meclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; PC3; HT_HG-U133A	PAPPA2 ELP1 ZNF442 FRMD4A PCNX1 PCM1 SAMD4A	7.90e-05	198	118	7	3707_DN
Drug	Propidium iodide [25535-16-4]; Down 200; 6uM; HL60; HT_HG-U133A	ZNF93 UBE3B XRCC4 ITGB4 RYR2 PCM1 RASGRP2	7.90e-05	198	118	7	2541_DN
Drug	3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester	TNF NOS2	7.96e-05	3	118	2	ctd:C521391
Drug	martentoxin, Buthus martensi	TNF NOS2	7.96e-05	3	118	2	ctd:C471035
Drug	RV09 compound	TNF NOS2	7.96e-05	3	118	2	ctd:C531164
Drug	NCX 6560	TNF NOS2	7.96e-05	3	118	2	ctd:C524539
Drug	dendrochrysanene	TNF NOS2	7.96e-05	3	118	2	ctd:C512279
Drug	2-aminothiophenol	C4A C4B	7.96e-05	3	118	2	ctd:C005464
Drug	S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea	TNF NOS2	7.96e-05	3	118	2	ctd:C118852
Drug	sulglicotide	TNF NOS2	7.96e-05	3	118	2	ctd:C009354
Drug	caldarchaeol	STK36 C4A	7.96e-05	3	118	2	CID005388885
Drug	eutigoside C	TNF NOS2	7.96e-05	3	118	2	ctd:C505499
Drug	Butirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A	MCPH1 KALRN MUC5B XRCC4 ZNF442 ITGB4 FBLN1	8.15e-05	199	118	7	6080_UP
Drug	CP-690334-01 [459212-38-5]; Down 200; 1uM; MCF7; HT_HG-U133A	HCN4 FRMD4A FBLN1 PCNX1 TPSG1 KIF13A UTRN	8.15e-05	199	118	7	4383_DN
Drug	Remoxipride Hydrochloride [73220-03-8]; Up 200; 9.8uM; PC3; HT_HG-U133A	PAPPA2 GAD2 MASP1 KALRN ELP1 FRMD4A PCNX1	8.15e-05	199	118	7	6342_UP
Drug	Vitexin [3681-93-4]; Up 200; 9.2uM; PC3; HT_HG-U133A	GAD2 MCPH1 MLXIP RYR2 MET PCNX1 UTRN	8.41e-05	200	118	7	4588_UP
Drug	DCFH-DA	BID DUOX1 TNF TPSG1 NOS2	8.56e-05	86	118	5	CID000104913
Drug	Apigenin	BID MET FRMD4A DUOX1 TNF UTRN NOS2	1.04e-04	207	118	7	ctd:D047310
Drug	6-formylpterin	BID AGXT NOS2	1.05e-04	18	118	3	CID000150847
Disease	cholangiocarcinoma (is_marker_for)	MUC16 MUC5B MET MUC4 NOS2	6.18e-06	64	119	5	DOID:4947 (is_marker_for)
Disease	otitis media (biomarker_via_orthology)	TNF MUC4 NOS2	4.17e-05	17	119	3	DOID:10754 (biomarker_via_orthology)
Disease	serine/threonine-protein kinase BRSK2 measurement	BRSK2 BRSK1	4.83e-05	3	119	2	EFO_0803063
Disease	information processing speed, response to cranial radiation therapy	CUL9 FAM171A1 FRMD4A SIGLEC1	9.02e-05	58	119	4	EFO_0004363, EFO_0010950
Disease	Stunned Myocardium	TNF NOS2	9.63e-05	4	119	2	C0206145
Disease	Myocardial Stunning	TNF NOS2	9.63e-05	4	119	2	C0206146
Disease	Hibernation, Myocardial	TNF NOS2	9.63e-05	4	119	2	C0376416
Disease	Drug habituation	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C0013170
Disease	Drug abuse	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C0013146
Disease	Prescription Drug Abuse	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C4316881
Disease	Substance-Related Disorders	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C0236969
Disease	Drug Use Disorders	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C0013222
Disease	Drug Dependence	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C1510472
Disease	Substance Dependence	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C0038580
Disease	Substance Use Disorders	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C0038586
Disease	Organic Mental Disorders, Substance-Induced	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.06e-04	115	119	5	C0029231
Disease	Substance abuse problem	THSD4 SLC6A4 FRMD4A EHHADH SAMD4A	1.10e-04	116	119	5	C0740858
Disease	Polydactyly	UBE3B PORCN C2CD3 ALMS1 LRP4	1.15e-04	117	119	5	C0152427
Disease	Involutional paraphrenia	GAD2 FREM3 SLC6A4	1.38e-04	25	119	3	C1571983
Disease	Psychosis, Involutional	GAD2 FREM3 SLC6A4	1.38e-04	25	119	3	C1571984
Disease	Involutional Depression	GAD2 FREM3 SLC6A4	1.38e-04	25	119	3	C0011574
Disease	mucositis (biomarker_via_orthology)	MUC4 NOS2	1.60e-04	5	119	2	DOID:0080178 (biomarker_via_orthology)
Disease	renal cell carcinoma (is_implicated_in)	MET C4A C4B TNF	1.78e-04	69	119	4	DOID:4450 (is_implicated_in)
Disease	Endotoxic shock	TNF NOS2	2.39e-04	6	119	2	C0036981
Disease	Septic Shock	TNF NOS2	2.39e-04	6	119	2	C0036983
Disease	Toxic Shock Syndrome	TNF NOS2	2.39e-04	6	119	2	C0600327
Disease	Vasogenic Brain Edema	TNF NOS2	4.44e-04	8	119	2	C0750969
Disease	Cytotoxic Brain Edema	TNF NOS2	4.44e-04	8	119	2	C0750970
Disease	Cytotoxic Cerebral Edema	TNF NOS2	4.44e-04	8	119	2	C0472388
Disease	Vasogenic Cerebral Edema	TNF NOS2	4.44e-04	8	119	2	C0472387
Disease	generalized anxiety disorder (implicated_via_orthology)	ZNF462 SLC6A4	4.44e-04	8	119	2	DOID:14320 (implicated_via_orthology)
Disease	Brain Edema	TNF NOS2	4.44e-04	8	119	2	C1527311
Disease	Cerebral Edema	TNF NOS2	4.44e-04	8	119	2	C0006114
Disease	Graves' disease (is_implicated_in)	C4A C4B TNF	5.26e-04	39	119	3	DOID:12361 (is_implicated_in)
Disease	autistic disorder (is_implicated_in)	SLC6A4 MET C4B	6.55e-04	42	119	3	DOID:12849 (is_implicated_in)
Disease	transcription factor IIIb 90 kda subunit measurement	PIKFYVE EHHADH	7.11e-04	10	119	2	EFO_0020778
Disease	Asthma, Occupational	TENM3 TNF	7.11e-04	10	119	2	C0264423
Disease	otitis media (is_marker_for)	MUC5B MUC4	7.11e-04	10	119	2	DOID:10754 (is_marker_for)
Disease	pancreatic cancer (is_marker_for)	MUC16 MET MUC4 NOS2	7.60e-04	101	119	4	DOID:1793 (is_marker_for)
Disease	Diabetic Cardiomyopathies	RYR2 TNF	8.66e-04	11	119	2	C0853897
Disease	obstructive sleep apnea (is_implicated_in)	SLC6A4 TNF	8.66e-04	11	119	2	DOID:0050848 (is_implicated_in)
Disease	alcohol use disorder (implicated_via_orthology)	GAD2 ACSS2 RYR2 CHRND SSH2	1.19e-03	195	119	5	DOID:1574 (implicated_via_orthology)
Disease	cholangiocarcinoma (biomarker_via_orthology)	MET MUC4	1.22e-03	13	119	2	DOID:4947 (biomarker_via_orthology)
Disease	pleurisy (implicated_via_orthology)	TNF NOS2	1.22e-03	13	119	2	DOID:10247 (implicated_via_orthology)
Disease	Manganese Poisoning	TNF NOS2	1.42e-03	14	119	2	C0677050
Disease	Hypothermia, natural	TNF NOS2	1.42e-03	14	119	2	C0020672
Disease	Arthritis, Psoriatic	TNF NOS2	1.42e-03	14	119	2	C0003872
Disease	Asbestosis	TNF NOS2	1.42e-03	14	119	2	C0003949
Disease	Pulmonary Fibrosis - from Asbestos Exposure	TNF NOS2	1.42e-03	14	119	2	C2930617
Disease	Psoriasis	TAGAP TNF NOS2	1.60e-03	57	119	3	C0033860
Disease	Pustulosis of Palms and Soles	TAGAP TNF NOS2	1.60e-03	57	119	3	C0030246
Disease	acute graft vs. host disease, donor genotype effect measurement	KALRN SDK1	1.64e-03	15	119	2	EFO_0004599, EFO_0007892
Disease	multiple myeloma (is_implicated_in)	XRCC4 MET TNF	1.76e-03	59	119	3	DOID:9538 (is_implicated_in)
Disease	Myasthenic Syndromes, Congenital, Slow Channel	CHRND LRP4	1.87e-03	16	119	2	C0751885
Disease	Malaria, susceptibility to	TNF NOS2	1.87e-03	16	119	2	cv:C1970028
Disease	–	TNF NOS2	1.87e-03	16	119	2	611162
Disease	pancreatic ductal carcinoma (is_marker_for)	MUC5B MET MUC4	1.94e-03	61	119	3	DOID:3587 (is_marker_for)
Disease	Arsenic Induced Polyneuropathy	RFX3 TRAPPC10 TNF	2.03e-03	62	119	3	C0751852
Disease	Arsenic Encephalopathy	RFX3 TRAPPC10 TNF	2.03e-03	62	119	3	C0751851
Disease	Arsenic Poisoning	RFX3 TRAPPC10 TNF	2.03e-03	62	119	3	C0311375
Disease	cystic fibrosis (is_marker_for)	MUC5B TNF NOS2	2.03e-03	62	119	3	DOID:1485 (is_marker_for)
Disease	systemic lupus erythematosus (is_implicated_in)	C4A C4B TNF	2.03e-03	62	119	3	DOID:9074 (is_implicated_in)
Disease	Arsenic Poisoning, Inorganic	RFX3 TRAPPC10 TNF	2.03e-03	62	119	3	C0274861
Disease	Nervous System, Organic Arsenic Poisoning	RFX3 TRAPPC10 TNF	2.03e-03	62	119	3	C0274862
Disease	Congenital Myasthenic Syndromes, Postsynaptic	CHRND LRP4	2.11e-03	17	119	2	C0751883
Disease	Gastric ulcer	TNF NOS2	2.37e-03	18	119	2	C0038358
Disease	Tachycardia	RYR2 TNF	2.37e-03	18	119	2	C0039231
Disease	Tachyarrhythmia	RYR2 TNF	2.37e-03	18	119	2	C0080203
Disease	Congenital Myasthenic Syndromes, Presynaptic	CHRND LRP4	2.64e-03	19	119	2	C0751884
Disease	ovarian cancer (is_marker_for)	MET TNF UTRN	2.65e-03	68	119	3	DOID:2394 (is_marker_for)
Disease	Malaria	TNF NOS2	2.92e-03	20	119	2	C0024530
Disease	myocardial infarction	PAPPA2 KALRN NDST2 DCLRE1B SLC6A4 TENM3	3.01e-03	350	119	6	EFO_0000612
Disease	Major Depressive Disorder	GAD2 KALRN FREM3 SLC6A4 TNF	3.10e-03	243	119	5	C1269683
Disease	periodontitis (biomarker_via_orthology)	MET TNF	3.22e-03	21	119	2	DOID:824 (biomarker_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NDST2 ZNF280B SLC6A4 MET	3.40e-03	152	119	4	DOID:0060041 (implicated_via_orthology)
Disease	Dermatologic disorders	RFX3 TRAPPC10 TNF	3.50e-03	75	119	3	C0037274
Disease	intellectual disability (implicated_via_orthology)	RBL2 NDST2 ZNF280B	3.50e-03	75	119	3	DOID:1059 (implicated_via_orthology)
Disease	impotence (biomarker_via_orthology)	TNF NOS2	3.53e-03	22	119	2	DOID:1875 (biomarker_via_orthology)
Disease	Bronchiectasis	TNF DNAH11	3.53e-03	22	119	2	C0006267
Disease	asthma (is_implicated_in)	ELP1 SLC6A4 TNF NOS2	3.81e-03	157	119	4	DOID:2841 (is_implicated_in)
Disease	Morbilliform Drug Reaction	C4B TNF	3.86e-03	23	119	2	C0406537
Disease	Drug Eruptions	C4B TNF	3.86e-03	23	119	2	C0011609
Disease	PR interval	HCN4 KALRN UBE3B CUL9 RYR2 SLC6A4 DNAH11	4.01e-03	495	119	7	EFO_0004462

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSTHIRVLAFSLSSI	TMEM62	336	Q0P6H9
ITFTDSLHHPVSTAL	ZNF280B	146	Q86YH2
LNIHFRTPSTHVLSE	CHRND	331	Q07001
SFTLHLQSPTTHVTE	nan	186	Q9N2J8
HVASRLTSPIVSTHL	ANKRD13D	221	Q6ZTN6
LTSVSVFVDHHLAPS	C4B	526	P0C0L5
FSHLHSLRTQPEVTS	ADGRG4	1436	Q8IZF6
SILSHTTRTFTIHAV	CEACAM20	206	Q6UY09
ESQHARHLSSTTPVF	H2AL3	36	A0A3B3IU63
IPTVSSTSHSHVEDL	ALMS1	661	Q8TCU4
TVEHTHLSPVDFLTS	DNAH11	3811	Q96DT5
STVADPSVISHLFSH	ACSS2	681	Q9NR19
TIAILPTSRKIHSSH	DCLRE1B	251	Q9H816
TPHLSTTATIIVHLV	CDHR4	636	A6H8M9
HITEPSTVTSHTLAA	MUC5B	2226	Q9HC84
RSAATLITHPFHVIT	MTCH2	131	Q9Y6C9
VTPVSTATHSLSRLH	RBL2	416	Q08999
FTLTSAPHEDTLSLH	DUOX1	1321	Q9NRD9
SSSRDHTPTEIHLTV	NOS2	911	P35228
LTFPSIETHIHVSTA	MUC16	1281	Q8WXI7
TTISHFPEKTTHSFR	MUC16	2261	Q8WXI7
THSFRTISSLTHELT	MUC16	2271	Q8WXI7
SSAHVLHSTLPVSSE	MUC16	4546	Q8WXI7
TESTHHLSTDLLPSA	MUC16	10256	Q8WXI7
SLSTRHATSLHVTSP	MUC4	2536	Q99102
PRLIAFTSEHSHFSL	GAD2	271	Q05329
TRHDLTPVTAVSVHL	FAM171A1	196	Q5VUB5
SSLSHPDLTSVIHLT	MDN1	2911	Q9NU22
IYTPTIEINSRHHSA	MCPH1	161	Q8NEM0
SRLKETHSHVSPETI	RASGRP2	256	Q7LDG7
YFTRHSTLISIPHSL	KCTD16	36	Q68DU8
RSIHPEAFSTLHSLV	LGR6	411	Q9HBX8
HSSFISRRHLEIFTP	FOXK2	71	Q01167
HRSSSTTEIEIIAPH	KCNH6	196	Q9H252
VHAFLSIPSLSHSVI	BRSK2	551	Q8IWQ3
STDRPHLVIGTHFFS	EHHADH	421	Q08426
PVQHISFSSHSLITA	FBXW8	516	Q8N3Y1
ASLSSHRSSLVDEHP	PCM1	636	Q15154
TEVASLVPLHSHSYR	PCNX1	261	Q96RV3
TPHSSSISHIESVLQ	KALRN	731	O60229
EFSPRSVIHHLTAAS	ELP1	521	O95163
SAEHTSSLVPSLHIT	KIAA1549L	166	Q6ZVL6
SRLPHHSSAVITAAS	NAGS	341	Q8N159
VSQSHHLFSSILPST	HEG1	681	Q9ULI3
HLFSSILPSTRASVH	HEG1	686	Q9ULI3
HPVSTVTDHRSQISS	GAL3ST4	261	Q96RP7
HVPHRVLSTSSTLTR	ITGB4	1476	P16144
AATTSVAIALTHHPR	HCN4	786	Q9Y3Q4
SGRSLLSTHYTIVIH	PLEKHH2	876	Q8IVE3
THLLRHSEPSKLTFV	MAN1B1	496	Q9UKM7
PQHVSVHVLSSTTAL	PTPRO	436	Q16827
HSSHRGVFLSVTILI	PORCN	91	Q9H237
ISHTVISLPTFREFT	FBLN1	596	P23142
PSVITHTASATLTHD	MLXIP	481	Q9HAP2
HHTTSVLLNFSSPRV	PAPPA2	1336	Q9BXP8
AVLRTSIHSDSHFLS	PIKFYVE	1996	Q9Y2I7
HSTRSVDISPTRLHS	FRMD4A	686	Q9P2Q2
VTHLIRSSRTPHSTR	CRNKL1	76	Q9BZJ0
VVLSSLSSHLEPTHE	C2CD3	1556	Q4AC94
ATVNRHSTIPSDTHT	LINC00322	11	Q6ZN03
TSHLPTSLAADRTLH	C19orf44	276	Q9H6X5
HAFLSIPSLSHSVLS	BRSK1	626	Q8TDC3
SHTPSLLRDVFHTTV	BID	161	P55957
SAHAILPEASTSHIV	MS4A14	411	Q96JA4
TTIRTHPTLHDSERA	MARVELD2	26	Q8N4S9
EPISTQSHSVLILFH	MASP1	266	P48740
PSLTAAVLHTIHVLS	CUL9	136	Q8IWT3
HSLTPTFAAVLVHID	H6PD	331	O95479
TFSESSEHSHLLVSP	BEAN1	21	Q3B7T3
SEHSHLLVSPVLVAS	BEAN1	26	Q3B7T3
RLASSSPHTFTTVEV	SDK1	1416	Q7Z5N4
HTEPFVTAEATHLRV	RYR2	681	Q92736
HSLSHRQPETVLTET	CDC27	191	P30260
PRSTVSILDDHISHY	MEST	301	Q5EB52
IHPTENITFHAVSSV	HMCES	241	Q96FZ2
LTSVSVFVDHHLAPS	C4A	526	P0C0L4
TITPNSHFHVLTRSR	PCDHB3	171	Q9Y5E6
QDRLISVTYTHHSPT	OR10J3	271	Q5JRS4
SLVTTSLVFHLPFHS	OR10K1	156	Q8NGX5
DSTEHSTPSLVHDFR	KIF13A	1631	Q9H1H9
SVSTTREPISSEHLH	FANK1	101	Q8TC84
SSDEHHFSITRAPSL	FREM3	1456	P0C091
HTPHLDRLVSARSVS	MET	976	P08581
SIISPHHTSEDSELI	UTRN	3301	P46939
HHTIPVISLYSLRES	AGXT	261	P21549
SPHFSTVRQIILHSS	TPSG1	101	Q9NRR2
IPVHSSITSDDSLEH	TAGAP	281	Q8N103
HSVTHTTRASPATIE	RFX3	146	P48380
TLTIETVIIHPHFST	OVCH2	121	Q7RTZ1
PEHENRISHVSTSSV	INPPL1	516	O15357
SSPSFSHHRTLSLFI	RUSC1-AS1	126	Q66K80
AHTARVLSPSHLSFI	STK36	1086	Q9NRP7
PHFITSSVEHDSIRL	SCLY	136	Q96I15
LSSLTSFQTHVRLHS	ZNF440	321	Q8IYI8
AFISPSSLSRHEIIH	ZNF93	601	P35789
FATSEELLSHLRTHT	ZNF703	471	Q9H7S9
FTRSTTLPVHERTHT	ZNF20	236	P17024
SHHLVTTETRPLTLV	ZNF143	586	P52747
ALRPHSVTHTREITL	ZNF596	181	Q8TC21
LETAAPFVSHTTHLL	SSH2	1111	Q76I76
PFVSHTTHLLSASLD	SSH2	1116	Q76I76
QVLHFTVREHPSVSE	TMEM232	561	C9JQI7
EQVSSHITSSPLHSR	STX16	26	O14662
HITSSPLHSRSIAAE	STX16	31	O14662
IHTHPTQTAFLSSVD	STAMBPL1	346	Q96FJ0
LRHVVFTAETHNFPT	PFAS	301	O15067
SEIPRRSHHSISSQT	RLIM	236	Q9NVW2
PSTDVVTLDHVTHSV	ZBTB41	121	Q5SVQ8
SRIHLVSEPSITHFL	XRCC4	6	Q13426
TSFHLRKPSVHISDT	TRAV8-6	91	A0A0B4J262
TTAIHFFLSLHPAVT	NDST2	616	P52849
PTRITHVYNHSSSEI	TENM3	2256	Q9P273
ISLHVSYAPRHVTLT	SIGLEC1	976	Q9BZZ2
LEPIISSSAHHVTTV	NUP153	566	P49790
FSRISALVIHTAIHT	ZNF813	476	Q6ZN06
SSHSIKEPVSTLHRL	PLEKHA3	221	Q9HB20
AFSVSSSLRIHERTH	ZNF442	301	Q9H7R0
TSEELLSHLRTHTAF	ZNF503	531	Q96F45
VETSSASPHVTHITI	UBE3B	671	Q7Z3V4
EEPVSTSHFSTSHLV	ZNF462	1641	Q96JM2
TVHTALLHPTTLSQS	SFTA3	66	P0C7M3
VIALTFSVPFRTTHS	TRAPPC10	936	P48553
ADHVVSAVRTSVPLH	THSD4	101	Q6ZMP0
TTHQELFPHSLLSVI	POLR1B	656	Q9H9Y6
HSIPATTTTLVAELH	SLC6A4	61	P31645
SHSTSSTFHRIIPTK	ZNF571	121	Q7Z3V5
THSSVQRTRSLPVHT	SAMD4A	656	Q9UPU9
PSTHVLLTHTISRIA	TNF	146	P01375
TTSVHGEEPTTFHSR	MUC12	1321	Q9UKN1
TFHSRPASTHTTLFT	MUC12	1331	Q9UKN1
HSRPASTHTTLFTED	MUC12	2416	Q9UKN1
TFHSRPASTHTTLFT	MUC12	3971	Q9UKN1
RISLDTSDHTDVHVP	LRP4	1366	O75096