Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessRNA splicing

RBM15B SCAF1 USP39 SNRNP70 ZC3H13 HNRNPA3

1.43e-05502236GO:0008380
GeneOntologyBiologicalProcessmRNA processing

RBM15B SCAF1 USP39 SNRNP70 ZC3H13 HNRNPA3

2.42e-05551236GO:0006397
GeneOntologyBiologicalProcessmRNA metabolic process

RBM15B SCAF1 USP39 SNRNP70 ZC3H13 HNRNPA3

4.00e-04917236GO:0016071
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

RBM15B USP39 SNRNP70 HNRNPA3

6.09e-04358234GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

RBM15B USP39 SNRNP70 HNRNPA3

6.09e-04358234GO:0000377
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

RBM15B USP39 SNRNP70 HNRNPA3

6.35e-04362234GO:0000375
GeneOntologyCellularComponentRNA N6-methyladenosine methyltransferase complex

RBM15B ZC3H13

5.75e-059272GO:0036396
DomainRRM_1

NELFE RBM15B SNRNP70 HNRNPA3

1.12e-04208234PF00076
DomainRRM

NELFE RBM15B SNRNP70 HNRNPA3

1.32e-04217234SM00360
DomainRRM_dom

NELFE RBM15B SNRNP70 HNRNPA3

1.57e-04227234IPR000504
DomainRRM

NELFE RBM15B SNRNP70 HNRNPA3

1.65e-04230234PS50102
Domain-

NELFE RBM15B SNRNP70 HNRNPA3

2.07e-042442343.30.70.330
DomainNucleotide-bd_a/b_plait

NELFE RBM15B SNRNP70 HNRNPA3

2.56e-04258234IPR012677
PathwayKEGG_SPLICEOSOME

USP39 SNRNP70 HNRNPA3

1.91e-04127133M2044
PathwayWP_MRNA_PROCESSING

NELFE RBM15B SNRNP70 HNRNPA3

5.87e-04451134MM15946
PathwayREACTOME_MRNA_SPLICING

USP39 SNRNP70 HNRNPA3

7.35e-04201133MM15411
PathwayREACTOME_MRNA_SPLICING

USP39 SNRNP70 HNRNPA3

8.58e-04212133M14033
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

USP39 SNRNP70 HNRNPA3

1.85e-03277133MM15414
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

USP39 SNRNP70 HNRNPA3

1.97e-03283133M13087
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

RBM15B SCAF1 EIF3A USP39 SNRNP70 ZC3H13 ZFP91 HNRNPA3

3.23e-1036128826167880
Pubmed

A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.

NBPF10 NBPF19 NBPF20 NBPF1

1.99e-092128416079250
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

RBM15B EIF3A USP39 SNRNP70 ZC3H13 MPRIP ZFP91 HNRNPA3

2.42e-0784728835850772
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

RBM15B EIF3A USP39 SNRNP70 HDGFL2 ZC3H13 HNRNPA3

4.01e-0760528728977666
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

NELFE RBM15B USP39 SNRNP70 ZC3H13 MPRIP HNRNPA3

1.20e-0671328729802200
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

RBM15B SCAF1 USP39 HDGFL2 ZC3H13

1.61e-0625128531076518
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NELFE RBM15B SCAF1 KDM5C ZC3H13 ZFP91 SMTN

2.07e-0677428715302935
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

RBM15B ATF7 SCAF1 USP39 SNRNP70 HDGFL2 ZC3H13 HNRNPA3

5.74e-06129428830804502
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

EIF3A USP39 SNRNP70 HDGFL2 MPRIP HNRNPA3

1.20e-0566028632780723
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

NELFE ATF7 EIF3A USP39 HDGFL2 KDM5C ZFP91

1.21e-05101428732416067
Pubmed

A comprehensive resource of interacting protein regions for refining human transcription factor networks.

ATF7 USP39 SNRNP70 ZC3H13

1.63e-0519128420195357
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

RBM15B EIF3A USP39 SNRNP70 ZC3H13 HNRNPA3

2.14e-0573128629298432
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

EIF3A USP39 SNRNP70 HDGFL2 HNRNPA3

2.48e-0544128531239290
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

NBPF10 RBM15B EIF3A SNRNP70 ZC3H13 HNRNPA3

3.73e-0580728622681889
Pubmed

The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.

EIF3A SNRNP70 ZC3H13 HNRNPA3

3.91e-0523928426641092
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

PEG3 SMTN HNRNPA3

4.57e-058628337253089
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

NELFE EIF3A USP39 SNRNP70 HDGFL2 MPRIP HNRNPA3

5.51e-05128428717353931
Pubmed

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.

EIF3A SNRNP70 MPRIP

6.16e-059528333863777
Pubmed

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

USP39 SNRNP70 HDGFL2

8.06e-0510428326167872
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

NELFE RBM15B SCAF1 SNRNP70 PEG3 MPRIP ZFP91

8.32e-05137128736244648
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

NELFE RBM15B SNRNP70 HDGFL2 ZC3H13 HNRNPA3

9.42e-0595428636373674
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

NELFE SCAF1 EIF3A USP39 SNRNP70 HNRNPA3

1.15e-0498928636424410
Pubmed

Identification of novel ARF binding proteins by two-hybrid screening.

EIF3A ZFP91

1.30e-042128216582619
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

NELFE RBM15B SNRNP70 HNRNPA3

1.65e-0434728416033648
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NELFE ATF7 USP39 SNRNP70 ZFP91 HNRNPA3

2.08e-04110328634189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA3F SCAF1 MARVELD3 SOWAHB NBPF1 MPRIP

2.10e-04110528635748872
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

NELFE RBM15B EIF3A ZC3H13 MPRIP

2.19e-0470128530196744
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

NELFE HDGFL2 HNRNPA3

2.29e-0414828332538781
Pubmed

UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.

SNRNP70 ZC3H13 ZFP91

2.62e-0415528334921745
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

DYNC2I1 EIF3A USP39 MPRIP SMTN HNRNPA3

2.66e-04115528620360068
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

SNRNP70 HDGFL2 ZC3H13 HNRNPA3

2.81e-0439928435987950
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

SNRNP70 HDGFL2 ZC3H13

3.04e-0416328322113938
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

NBPF10 SEMA3F NBPF1

3.44e-0417028323314748
Pubmed

DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.

RBM15B EIF3A

3.66e-043528224515614
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

RBM15B EIF3A USP39 ZC3H13 MPRIP HNRNPA3

4.19e-04125728636526897
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

EIF3A SNRNP70 HDGFL2 ZC3H13 HNRNPA3

5.22e-0484728535235311
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

RBM15B SNRNP70 ZC3H13

5.28e-0419728320811636
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

SNRNP70 HDGFL2 ZFP91 SMTN

5.30e-0447228438943005
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

EIF3A ZC3H13 MPRIP HNRNPA3

5.51e-0447728431300519
Pubmed

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.

USP39 SNRNP70 HNRNPA3

6.01e-0420628322174317
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

USP39 SH3RF3 HDGFL2 KDM5C

6.43e-0449728436774506
Pubmed

Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.

ZC3H13 ZFP91

6.61e-044728215009096
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

NELFE SNRNP70 KDM5C ZC3H13

6.72e-0450328416964243
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

NELFE SNRNP70 HDGFL2 MPRIP

6.87e-0450628430890647
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

EIF3A USP39 HNRNPA3

7.28e-0422028324550385
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

NELFE EIF3A USP39 SNRNP70 HDGFL2 HNRNPA3

7.82e-04141528628515276
InteractionSSRP1 interactions

NELFE SCAF1 EIF3A USP39 SNRNP70 HDGFL2 ZC3H13 ZFP91 HNRNPA3

1.55e-07685279int:SSRP1
InteractionSRPK2 interactions

NELFE RBM15B SCAF1 EIF3A USP39 SNRNP70 ZC3H13 ZFP91 HNRNPA3

2.29e-07717279int:SRPK2
InteractionTMSB4Y interactions

RBM15B ZC3H13 MPRIP

1.90e-0539273int:TMSB4Y
InteractionSNRNP70 interactions

NELFE RBM15B SCAF1 USP39 SNRNP70 ZC3H13 MPRIP HNRNPA3

3.04e-05984278int:SNRNP70
InteractionDDX21 interactions

NELFE EIF3A USP39 SNRNP70 SURF2 ZFP91 HNRNPA3

3.37e-05718277int:DDX21
InteractionUQCR11 interactions

RBM15B ZC3H13 MPRIP

4.80e-0553273int:UQCR11
InteractionZC3H13 interactions

EIF3A SNRNP70 ZC3H13 ZFP91

5.55e-05158274int:ZC3H13
InteractionSRSF1 interactions

NELFE SCAF1 USP39 SNRNP70 ZFP91 HNRNPA3

8.89e-05570276int:SRSF1
InteractionSLFN11 interactions

EIF3A USP39 SNRNP70 KDM5C MPRIP

1.27e-04376275int:SLFN11
InteractionZRANB2 interactions

DYNC2I1 USP39 SNRNP70 HDGFL2

1.35e-04199274int:ZRANB2
InteractionSNRNP40 interactions

SCAF1 USP39 SNRNP70 HDGFL2 ZC3H13 HNRNPA3

1.63e-04637276int:SNRNP40
InteractionCHD4 interactions

NELFE RBM15B EIF3A USP39 SNRNP70 HDGFL2 HNRNPA3

1.81e-04938277int:CHD4
InteractionSRSF7 interactions

NELFE DYNC2I1 SCAF1 USP39 SNRNP70

2.24e-04425275int:SRSF7
InteractionNUPR1 interactions

EIF3A USP39 SNRNP70 HDGFL2 MPRIP HNRNPA3

2.39e-04683276int:NUPR1
InteractionLINC02910 interactions

RBM15B DYNC2I1 ZC3H13

2.73e-0495273int:LINC02910
InteractionRAD18 interactions

RBM15B SCAF1 USP39 HDGFL2 ZC3H13

3.14e-04457275int:RAD18
InteractionMEN1 interactions

NELFE ATF7 EIF3A USP39 SNRNP70 ZC3H13 ZFP91

3.20e-041029277int:MEN1
InteractionTSPYL2 interactions

KDM5C ZFP91 HNRNPA3

3.67e-04105273int:TSPYL2
InteractionRRP8 interactions

SCAF1 USP39 SNRNP70 HNRNPA3

3.71e-04259274int:RRP8
InteractionDDX23 interactions

SCAF1 USP39 SNRNP70 HDGFL2 ZC3H13

3.93e-04480275int:DDX23
InteractionANKRD50 interactions

RBM15B ZC3H13 MPRIP

3.99e-04108273int:ANKRD50
Cytoband19q13.4

TNNI3 PEG3

1.07e-037928219q13.4
CytobandEnsembl 112 genes in cytogenetic band chr1q21

NBPF10 NBPF19 NBPF20

1.88e-03404283chr1q21
GeneFamilyNeuroblastoma breakpoint family

NBPF10 NBPF19 NBPF20 NBPF1

1.17e-0823214662
GeneFamilyRNA binding motif containing

NELFE RBM15B SNRNP70 HNRNPA3

9.58e-05213214725
CoexpressionMENON_FETAL_KIDNEY_0_CAP_MESENCHYME_CELLS

EIF3A SNRNP70 ZC3H13 NBPF1

2.50e-0690284M39250
ToppCellMyeloid-Myeloid-B_(Activated_Macrophage)|Myeloid / shred on cell class and cell subclass (v4)

EIF3A ZC3H13 ZFP91 HNRNPA3

5.95e-061912847bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

DYNC2I1 EIF3A SNRNP70 ZC3H13

6.72e-061972840fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
Diseasecolorectal cancer (is_marker_for)

ATF7 KDM5C

7.19e-03157242DOID:9256 (is_marker_for)
Diseasedyslexia

SEMA3F SCAF1

7.64e-03162242EFO_0005424

Protein segments in the cluster

PeptideGeneStartEntry
GRRRRTVDEDPDERR

ATF7

321

P17544
KAGEEDLRFRERRPG

RBAKDN

46

A6NC62
KRPREREREAEAGGR

RBM15B

21

Q8NDT2
AEPGELERERARRRE

MPRIP

576

Q6WCQ1
RDRDRDREGPFRRSD

NELFE

236

P18615
AKESPRGERDRDRQR

DYNC2I1

76

Q8WVS4
GERRHRKPREPDRDN

DYNC2I1

211

Q8WVS4
RRRRGRKEGEEDQNP

NBPF1

1116

Q3BBV0
ERRRERADRGEAERG

HDGFL2

351

Q7Z4V5
HERERERERGETFRP

PEG3

596

Q9GZU2
DDRNDRDDGRRKPIA

CD99L2

126

Q8TCZ2
RRDEERPRRLGDDED

EIF3A

931

Q14152
ERERERERDPDRGPR

MARVELD3

76

Q96A59
DGPEEKGRDRDRERR

SNRNP70

341

P08621
DRDRDREHKRGERGS

SNRNP70

371

P08621
RDPGDRRREIRAEDR

SEMA3F

641

Q13275
GRVKRERDREREPEA

USP39

26

Q53GS9
ERRRGRKEGEEDQNP

NBPF10

1576

Q6P3W6
ERRRGRKEGEEDQNP

NBPF10

2796

Q6P3W6
ERRRGRKEGEEDQNP

NBPF19

1061

A0A087WUL8
ERRRGRKEGEEDQNP

NBPF19

2281

A0A087WUL8
ERRRGRKEGEEDQNP

NBPF19

3501

A0A087WUL8
ERRRGRKEGEEDQNP

NBPF20

961

P0DPF2
ERRRGRKEGEEDQNP

NBPF20

2181

P0DPF2
ERRRGRKEGEEDQNP

NBPF20

3401

P0DPF2
ERRRGRKEGEEDQNP

NBPF20

4546

P0DPF2
RRRRREDQMDGDGPR

SURF2

131

Q15527
RRRRREKEPEEEPAG

SOWAHB

121

A6NEL2
EGDEDRPGERRRRRA

SH3RF3

21

Q8TEJ3
KALDGGDRDRDRDRD

SCAF1

771

Q9H7N4
RRRRRRGEEGHDPKE

HNRNPA3

16

P51991
LEREAEERRGEKGRA

TNNI3

61

P19429
EIREDEEPPRKRGRR

ZFP91

276

Q96JP5
ERERRLQEARGRPGE

SMTN

626

P53814
HRDDREPRDGRDRRD

ZC3H13

446

Q5T200
EPRDGRDRRDARDTR

ZC3H13

451

Q5T200
ERRRRRKVDRGGEGD

KDM5C

1456

P41229