Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	delta-catenin binding	DACT3 CDH24	1.03e-04	11	28	2	GO:0070097
Domain	Ank_2	PSMD10 FEM1C FEM1A ANKS3	2.81e-04	215	28	4	PF12796
Domain	Ank	PSMD10 FEM1C FEM1A ANKS3	3.52e-04	228	28	4	PF00023
Domain	-	PSMD10 FEM1C FEM1A ANKS3	4.83e-04	248	28	4	1.25.40.20
Domain	ANK	PSMD10 FEM1C FEM1A ANKS3	5.06e-04	251	28	4	SM00248
Domain	ANK_REPEAT	PSMD10 FEM1C FEM1A ANKS3	5.21e-04	253	28	4	PS50088
Domain	Ankyrin_rpt-contain_dom	PSMD10 FEM1C FEM1A ANKS3	5.29e-04	254	28	4	IPR020683
Domain	ANK_REP_REGION	PSMD10 FEM1C FEM1A ANKS3	5.29e-04	254	28	4	PS50297
Domain	Ankyrin_rpt	PSMD10 FEM1C FEM1A ANKS3	5.94e-04	262	28	4	IPR002110
Pubmed	Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation.	GNAS HTR7	7.69e-07	2	31	2	29079700
Pubmed	Identification of human FEM1A, the ortholog of a C. elegans sex-differentiation gene.	FEM1C FEM1A	7.69e-07	2	31	2	11733146
Pubmed	FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome.	FEM1C FEM1A	2.31e-06	3	31	2	18757445
Pubmed	Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis.	IRAK1 PSMD10	2.31e-06	3	31	2	25294684
Pubmed	Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.	GNAS HTR7	4.61e-06	4	31	2	21184583
Pubmed	SMARCA4 oncogenic potential via IRAK1 enhancer to activate Gankyrin and AKR1B10 in liver cancer.	IRAK1 PSMD10	4.61e-06	4	31	2	34140644
Pubmed	Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron.	FEM1C FEM1A	7.68e-06	5	31	2	33398170
Pubmed	Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase.	FEM1C FEM1A	7.68e-06	5	31	2	33398168
Pubmed	FEM1 proteins are ancient regulators of SLBP degradation.	FEM1C FEM1A	3.44e-05	10	31	2	28118078
Pubmed	The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.	FEM1C FEM1A	3.44e-05	10	31	2	29779948
Pubmed	Multiplicity of mechanisms of serotonin receptor signal transduction.	GNAS HTR7	5.05e-05	12	31	2	11916537
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	POU3F2 HES5	6.95e-05	14	31	2	15273690
Pubmed	Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.	POU3F2 HES5	8.02e-05	15	31	2	38288355
Pubmed	Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation.	POU3F2 HES5	8.02e-05	15	31	2	22951639
Pubmed	Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development.	GDF10 HES5	9.16e-05	16	31	2	29326173
Pubmed	Sox21 promotes hippocampal adult neurogenesis via the transcriptional repression of the Hes5 gene.	POU3F2 HES5	1.04e-04	17	31	2	22956844
Pubmed	A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus.	POU3F2 HES5	1.45e-04	20	31	2	17916349
Pubmed	PDK1 Regulates Transition Period of Apical Progenitors to Basal Progenitors by Controlling Asymmetric Cell Division.	POU3F2 HES5	1.92e-04	23	31	2	31504280
Pubmed	Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis.	POU3F2 HES5	2.47e-04	26	31	2	26856890
Pubmed	The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.	POU3F2 HES5	2.86e-04	28	31	2	18794345
Pubmed	Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.	POU3F2 HES5	3.75e-04	32	31	2	19286674
Pubmed	Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex.	POU3F2 HES5	5.30e-04	38	31	2	31080058
Pubmed	Olig3 regulates early cerebellar development.	POU3F2 HES5	5.87e-04	40	31	2	33591268
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	DACT3 CA11 IL11 LENG8 LILRB5	1.13e-03	1192	31	5	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr10q26	TCERG1L NANOS1	8.63e-03	207	31	2	chr10q26
GeneFamily	Ankyrin repeat domain containing	PSMD10 FEM1C FEM1A ANKS3	1.28e-04	242	20	4	403
GeneFamily	Endogenous ligands	IL11 GDF10	2.78e-02	237	20	2	542
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL11 TFAP2E GDF10 MMP17	7.65e-06	183	31	4	f55081068213cc1cdb2acad58ff10f6b48b44c72
Disease	Precocious Puberty	MKRN3 GNAS	2.09e-05	7	30	2	C0034013
Disease	Cryptogenic sexual precocity	MKRN3 GNAS	2.09e-05	7	30	2	C0271527
Disease	Central Precocious Puberty	MKRN3 GNAS	2.09e-05	7	30	2	C0342543
Disease	Testotoxicosis	MKRN3 GNAS	2.79e-05	8	30	2	C1504412
Disease	Endogenous depression	GNAS HTR7	1.01e-03	46	30	2	C0011573
Disease	behavior	CCDC91 NANOS1	1.44e-03	55	30	2	GO_0007610
Disease	estrogen-receptor negative breast cancer	CCDC91 USHBP1	2.38e-03	71	30	2	EFO_1000650
Disease	behavioural disinhibition measurement	CACNA1I TCERG1L	2.65e-03	75	30	2	EFO_0006946

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAAAAWRHQPPSHSG	USHBP1	131	Q8N6Y0
PSRLNSPAWEASGLH	GNAS	41	P84996
WAALGAAAHIGPAPD	CA11	16	O75493
PQAAWAAPRAAARAH	TFAP2E	96	Q6VUC0
LAASAAWAGHLSSPP	CES1P1	11	Q9UKY3
IEGAPPLWAASAAGH	FEM1C	81	Q96JP0
ASWPAHLALAARPAR	FUT4	51	P22083
RWEAASSLHPPRGAG	LENG8	356	Q96PV6
VAGSHRAPAWSALPA	GDF10	31	P55107
LAAPARAWAGSREHP	CDH24	21	Q86UP0
LAPPSSAWGGIRAAH	IL11	161	P20809
APAWAAEPRLHAASG	NANOS1	186	Q8WY41
YGAHNLSPRWSAPSD	LILRB5	296	O75023
TGRAHSGAAPWQPLA	IRAK1	551	P51617
GGHPTSPAALSRAWA	DACT3	311	Q96B18
WAAFPAVSGVHLSPS	CCDC91	31	Q7Z6B0
VPAVGAHPRAAWRAA	CACNA1I	1071	Q9P0X4
IEGAPPLWAASAAGH	FEM1A	81	Q9BSK4
ALPGPSLDQWHRSAG	ARL6IP4	136	Q66PJ3
LASAHRPQGPADAWR	IDUA	421	P35475
AIARWHSSARPPGDA	ANKS3	481	Q6ZW76
AGSAWLFPAPATHNI	CPEB4	56	Q17RY0
DAGWSPLHIAASAGR	PSMD10	71	O75832
LPPGGIDAAFSWAHN	MMP17	426	Q9ULZ9
HHPGPGAWRSAAAAA	POU3F2	161	P20265
GAWRSAAAAAHLPPS	POU3F2	166	P20265
AAAAAHQPACGLWRP	HES5	151	Q5TA89
GADPVAGSWAPHLLS	HTR7	36	P34969
AAAAAHPFPALHGQW	TCERG1L	101	Q5VWI1
AGSGRWSADPAAHLA	TNRC18	786	O15417
SAAPDSALPHAARGW	MKRN3	41	Q13064
WSPHPAGASEALGAL	nan	36	Q8NAQ8
TAVWRPAPSGAAAEH	NEXN-AS1	131	Q8NBZ9