Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	interleukin-2 binding	IL2RA IL2RB	2.57e-05	3	59	2	GO:0019976
GeneOntologyMolecularFunction	interleukin-2 receptor activity	IL2RA IL2RB	2.57e-05	3	59	2	GO:0004911
GeneOntologyMolecularFunction	activin binding	FSTL3 ACVR1C	5.56e-04	12	59	2	GO:0048185
GeneOntologyBiologicalProcess	multi-multicellular organism process	SPAM1 UBTFL6 ATP7A STC2 EMP2 CSMD1 ACVR1C	2.25e-05	294	60	7	GO:0044706
GeneOntologyCellularComponent	interleukin-2 receptor complex	IL2RA IL2RB	7.83e-06	2	59	2	GO:0005893
GeneOntologyCellularComponent	cell surface	SELE HAVCR1 ITGA11 SPAM1 STAB2 TNFRSF10C EMP2 ACVR1C IL2RA IL2RB NOTCH3 CFHR4	5.26e-05	1111	59	12	GO:0009986
GeneOntologyCellularComponent	external side of plasma membrane	SELE ITGA11 SPAM1 STAB2 TNFRSF10C IL2RA IL2RB CFHR4	9.97e-05	519	59	8	GO:0009897
GeneOntologyCellularComponent	side of membrane	SELE ITGA11 SPAM1 STAB2 TNFRSF10C IL2RA IL2RB LYPD8 CFHR4	7.25e-04	875	59	9	GO:0098552
GeneOntologyCellularComponent	receptor complex	ITGA11 PLXND1 ACVR1C IL2RA IL2RB LRP1B NOTCH3	1.21e-03	581	59	7	GO:0043235
HumanPheno	Abnormal Sharpey fiber morphology	ATP7A IL2RA IL2RB NOTCH3	5.29e-06	33	19	4	HP:0100685
HumanPheno	Coarse hair	ATP7A RASA2 HEATR3 NOTCH3	5.16e-05	58	19	4	HP:0002208
HumanPheno	Central opacification of the cornea	TACSTD2 IL2RA IL2RB	5.61e-05	21	19	3	HP:0011493
HumanPheno	Pulmonary interstitial lymphocyte infiltration	IL2RA IL2RB	7.87e-05	4	19	2	HP:0033582
HumanPheno	Dural ectasia	THSD4 MYLK NOTCH3	8.48e-05	24	19	3	HP:0100775
HumanPheno	Abnormal spinal meningeal morphology	THSD4 MYLK NOTCH3	9.61e-05	25	19	3	HP:0010303
Domain	EGF	SELE EYS STAB2 OIT3 NRXN2 BRINP2 LRP1B TENM2 NOTCH3	5.74e-08	235	60	9	SM00181
Domain	EGF_3	SELE EYS STAB2 OIT3 NRXN2 LRP1B TENM2 NOTCH3	8.12e-07	235	60	8	PS50026
Domain	EGF-like_dom	SELE EYS STAB2 OIT3 NRXN2 LRP1B TENM2 NOTCH3	1.25e-06	249	60	8	IPR000742
Domain	EGF_1	SELE EYS STAB2 OIT3 NRXN2 LRP1B TENM2 NOTCH3	1.50e-06	255	60	8	PS00022
Domain	TSP_1	THSD4 CCN1 ISM1 ADAMTS20 ADAMTS14	1.76e-06	63	60	5	PF00090
Domain	EGF_2	SELE EYS STAB2 OIT3 NRXN2 LRP1B TENM2 NOTCH3	2.00e-06	265	60	8	PS01186
Domain	TSP1	THSD4 CCN1 ISM1 ADAMTS20 ADAMTS14	2.06e-06	65	60	5	SM00209
Domain	TSP1_rpt	THSD4 CCN1 ISM1 ADAMTS20 ADAMTS14	2.06e-06	65	60	5	IPR000884
Domain	TSP1	THSD4 CCN1 ISM1 ADAMTS20 ADAMTS14	2.06e-06	65	60	5	PS50092
Domain	EGF_CA	EYS STAB2 OIT3 LRP1B TENM2 NOTCH3	2.58e-06	122	60	6	SM00179
Domain	EGF-like_Ca-bd_dom	EYS STAB2 OIT3 LRP1B TENM2 NOTCH3	2.83e-06	124	60	6	IPR001881
Domain	EGF	SELE EYS STAB2 NRXN2 LRP1B NOTCH3	3.11e-06	126	60	6	PF00008
Domain	EGF-like_CS	SELE EYS STAB2 NRXN2 LRP1B TENM2 NOTCH3	1.97e-05	261	60	7	IPR013032
Domain	Sushi	SELE CSMD1 IL2RA CFHR4	2.32e-05	52	60	4	PF00084
Domain	CTCK_1	CCN1 MUC19 MUC5AC	2.49e-05	18	60	3	PS01185
Domain	CCP	SELE CSMD1 IL2RA CFHR4	2.70e-05	54	60	4	SM00032
Domain	NHR2	RUNX1T1 CBFA2T3	3.04e-05	3	60	2	IPR014896
Domain	NHR2	RUNX1T1 CBFA2T3	3.04e-05	3	60	2	PF08788
Domain	CBFA2T1/2/3	RUNX1T1 CBFA2T3	3.04e-05	3	60	2	IPR013289
Domain	SUSHI	SELE CSMD1 IL2RA CFHR4	3.12e-05	56	60	4	PS50923
Domain	Sushi_SCR_CCP_dom	SELE CSMD1 IL2RA CFHR4	3.35e-05	57	60	4	IPR000436
Domain	CT	CCN1 MUC19 MUC5AC	4.65e-05	22	60	3	SM00041
Domain	ADAM_spacer1	THSD4 ADAMTS20 ADAMTS14	5.33e-05	23	60	3	IPR010294
Domain	ADAM_spacer1	THSD4 ADAMTS20 ADAMTS14	5.33e-05	23	60	3	PF05986
Domain	Cys_knot_C	CCN1 MUC19 MUC5AC	6.89e-05	25	60	3	IPR006207
Domain	CTCK_2	CCN1 MUC19 MUC5AC	6.89e-05	25	60	3	PS01225
Domain	TAFH	RUNX1T1 CBFA2T3	1.01e-04	5	60	2	SM00549
Domain	TAFH	RUNX1T1 CBFA2T3	1.01e-04	5	60	2	PS51119
Domain	TAFH	RUNX1T1 CBFA2T3	1.01e-04	5	60	2	PF07531
Domain	TAFH_NHR1	RUNX1T1 CBFA2T3	1.01e-04	5	60	2	IPR003894
Domain	Growth_fac_rcpt_	EYS STAB2 CCN1 LRP1B NOTCH3	1.44e-04	156	60	5	IPR009030
Domain	VWC	CCN1 MUC19 MUC5AC	2.45e-04	38	60	3	SM00214
Domain	VWFC_2	CCN1 MUC19 MUC5AC	2.45e-04	38	60	3	PS50184
Domain	EGF_Ca-bd_CS	EYS OIT3 LRP1B NOTCH3	2.67e-04	97	60	4	IPR018097
Domain	EGF_CA	EYS OIT3 LRP1B NOTCH3	2.88e-04	99	60	4	PS01187
Domain	ASX_HYDROXYL	EYS OIT3 LRP1B NOTCH3	3.00e-04	100	60	4	PS00010
Domain	VWF_dom	CCN1 MUC19 MUC5AC	3.31e-04	42	60	3	IPR001007
Domain	EGF-type_Asp/Asn_hydroxyl_site	EYS OIT3 LRP1B NOTCH3	3.74e-04	106	60	4	IPR000152
Domain	TIL	MUC19 MUC5AC	6.56e-04	12	60	2	PF01826
Domain	C8	MUC19 MUC5AC	6.56e-04	12	60	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC19 MUC5AC	7.74e-04	13	60	2	IPR014853
Domain	C8	MUC19 MUC5AC	7.74e-04	13	60	2	SM00832
Domain	TIL_dom	MUC19 MUC5AC	9.01e-04	14	60	2	IPR002919
Domain	EGF_extracell	STAB2 LRP1B NOTCH3	9.47e-04	60	60	3	IPR013111
Domain	EGF_2	STAB2 LRP1B NOTCH3	9.47e-04	60	60	3	PF07974
Domain	Glyco_hormone_CN	CCN1 MUC5AC	1.04e-03	15	60	2	IPR006208
Domain	Cys_knot	CCN1 MUC5AC	1.04e-03	15	60	2	PF00007
Domain	VWD	MUC19 MUC5AC	1.18e-03	16	60	2	SM00216
Domain	VWF_type-D	MUC19 MUC5AC	1.18e-03	16	60	2	IPR001846
Domain	VWFD	MUC19 MUC5AC	1.18e-03	16	60	2	PS51233
Domain	VWD	MUC19 MUC5AC	1.18e-03	16	60	2	PF00094
Domain	VWC_out	MUC19 MUC5AC	1.68e-03	19	60	2	SM00215
Domain	PLAC	THSD4 ADAMTS14	1.68e-03	19	60	2	PS50900
Domain	PLAC	THSD4 ADAMTS14	1.68e-03	19	60	2	IPR010909
Domain	zf-MYND	RUNX1T1 CBFA2T3	2.05e-03	21	60	2	PF01753
Domain	Znf_MYND	RUNX1T1 CBFA2T3	2.25e-03	22	60	2	IPR002893
Domain	ZF_MYND_1	RUNX1T1 CBFA2T3	2.25e-03	22	60	2	PS01360
Domain	ZF_MYND_2	RUNX1T1 CBFA2T3	2.25e-03	22	60	2	PS50865
Domain	Peptidase_M12B_ADAM-TS	ADAMTS20 ADAMTS14	2.68e-03	24	60	2	IPR013273
Domain	FN3	MYLK FNDC3A IL2RB ANKFN1	2.95e-03	185	60	4	SM00060
Domain	hEGF	EYS NOTCH3	3.64e-03	28	60	2	PF12661
Domain	VWC	CCN1 MUC5AC	3.64e-03	28	60	2	PF00093
Domain	FN3	MYLK FNDC3A IL2RB ANKFN1	3.83e-03	199	60	4	PS50853
Domain	FN3_dom	MYLK FNDC3A IL2RB ANKFN1	4.56e-03	209	60	4	IPR003961
Domain	VWFC_1	CCN1 MUC5AC	5.96e-03	36	60	2	PS01208
Domain	Kazal_2	SLCO5A1 FSTL3	5.96e-03	36	60	2	PF07648
Domain	LAM_G_DOMAIN	EYS NRXN2	6.62e-03	38	60	2	PS50025
Domain	Peptidase_M12B_N	ADAMTS20 ADAMTS14	6.97e-03	39	60	2	IPR002870
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	THSD4 ADAMTS20 ADAMTS14 MUC5AC NOTCH3	2.65e-06	68	46	5	M27303
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD4 MUC19 ADAMTS20 ADAMTS14 MUC5AC	2.68e-05	109	46	5	MM15164
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	THSD4 ADAMTS20 ADAMTS14 MUC5AC NOTCH3	9.82e-05	143	46	5	M27275
Pathway	REACTOME_DISEASES_OF_METABOLISM	THSD4 AHCY ADAMTS20 ADAMTS14 MUC5AC NOTCH3	1.51e-04	250	46	6	M27554
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD4 ADAMTS20 ADAMTS14	2.74e-04	39	46	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD4 ADAMTS20 ADAMTS14	2.74e-04	39	46	3	MM15165
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD4 ADAMTS20 ADAMTS14 MUC5AC	4.61e-04	111	46	4	M27416
Pathway	REACTOME_INTERLEUKIN_2_SIGNALING	IL2RA IL2RB	4.61e-04	10	46	2	MM15618
Pathway	REACTOME_INTERLEUKIN_2_SIGNALING	IL2RA IL2RB	6.73e-04	12	46	2	M27893
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	THSD4 CCN1 ISM1 ADAMTS20 ADAMTS14	2.20e-07	75	61	5	20637190
Pubmed	Polymorphisms in the IL2RA and IL2RB genes in inflammatory bowel disease risk.	IL2RA IL2RB	3.03e-06	2	61	2	23972291
Pubmed	Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.	IL2RA IL2RB	3.03e-06	2	61	2	3925551
Pubmed	Differences in the interleukin-2 (IL-2) receptor system in human and mouse: alpha chain is required for formation of the functional mouse IL-2 receptor.	IL2RA IL2RB	3.03e-06	2	61	2	7489734
Pubmed	Donor-antigen Inoculation in the Testis Promotes Skin Allograft Acceptance Induced by Conventional Costimulatory Blockade via Induction of CD8 + CD122+ and CD4 + CD25+ Regulatory T Cells.	IL2RA IL2RB	3.03e-06	2	61	2	26569069
Pubmed	Notch3 signaling is associated with MUC5AC expression and favorable prognosis in patients with small intestinal adenocarcinomas.	MUC5AC NOTCH3	3.03e-06	2	61	2	24810798
Pubmed	Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.	IL2RA IL2RB	3.03e-06	2	61	2	2467293
Pubmed	Effect of IL2RA and IL2RB gene polymorphisms on lung cancer risk.	IL2RA IL2RB	3.03e-06	2	61	2	31279323
Pubmed	Soluble cytokine receptors (sIL-2Rα, sIL-2Rβ) induce subunit-specific behavioral responses and accumulate in the cerebral cortex and basal forebrain.	IL2RA IL2RB	3.03e-06	2	61	2	22558434
Pubmed	Prognostic value of the soluble interleukin-2 receptor level after patients with follicular lymphoma achieve a response to R-CHOP.	IL2RA IL2RB	3.03e-06	2	61	2	28413914
Pubmed	Purification and properties of a self-associating, 50-kDa copper-binding protein from brindled mouse livers.	ATP7A AHCY	3.03e-06	2	61	2	8419320
Pubmed	Lack of association of IL-2RA and IL-2RB polymorphisms with rheumatoid arthritis in a Han Chinese population.	IL2RA IL2RB	3.03e-06	2	61	2	23512675
Pubmed	Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Individuals with Asthma.	MUC5AC NOTCH3	3.03e-06	2	61	2	31922915
Pubmed	IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo.	IL2RA IL2RB	3.03e-06	2	61	2	18641329
Pubmed	Expression of IL-2alpha and IL-2beta receptors on the membrane surface of human sperm.	IL2RA IL2RB	3.03e-06	2	61	2	12230826
Pubmed	Association of IL2RA and IL2RB with rheumatoid arthritis: a replication study in a Dutch population.	IL2RA IL2RB	3.03e-06	2	61	2	19822714
Pubmed	Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia.	FSTL3 MSTN	3.03e-06	2	61	2	22568578
Pubmed	Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.	FSTL3 MSTN	3.03e-06	2	61	2	22052913
Pubmed	Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.	IL2RA IL2RB	3.03e-06	2	61	2	2785715
Pubmed	ETO-2, a new member of the ETO-family of nuclear proteins.	RUNX1T1 CBFA2T3	3.03e-06	2	61	2	10022820
Pubmed	The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum.	FSTL3 MSTN	3.03e-06	2	61	2	12194980
Pubmed	Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients.	IL2RA IL2RB	3.03e-06	2	61	2	35458517
Pubmed	Impact of genetic variants in IL-2RA and IL-2RB on breast cancer risk in Chinese Han women.	IL2RA IL2RB	3.03e-06	2	61	2	33507447
Pubmed	Association of IL-2RA and IL-2RB genes with erosive status in early rheumatoid arthritis patients (ESPOIR and RMP cohorts).	IL2RA IL2RB	3.03e-06	2	61	2	24200909
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	THSD4 TMEM168 GAB4 CSMD1 IL2RA IL2RB	7.23e-06	265	61	6	19240061
Pubmed	Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma.	CSMD1 LRP1B	9.07e-06	3	61	2	27636103
Pubmed	CNS erythroblastic sarcoma: a potential emerging pediatric tumor type characterized by NFIA::RUNX1T1/3 fusions.	RUNX1T1 CBFA2T3	9.07e-06	3	61	2	38243303
Pubmed	IL-2Rbeta links IL-2R signaling with Foxp3 expression.	IL2RA IL2RB	9.07e-06	3	61	2	17559173
Pubmed	Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.	IL2RA IL2RB	9.07e-06	3	61	2	20179739
Pubmed	Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line.	IL2RA IL2RB	9.07e-06	3	61	2	7734194
Pubmed	GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines.	IL2RA IL2RB	9.07e-06	3	61	2	11856346
Pubmed	PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.	SELE ITGA11	9.07e-06	3	61	2	38428409
Pubmed	Value of serum soluble interleukin-2 receptor as a diagnostic and predictive biomarker in sarcoidosis.	IL2RA IL2RB	9.07e-06	3	61	2	32248706
Pubmed	Intestinal inflammation observed in IL-2R/IL-2 mutant mice is associated with impaired intestinal T lymphopoiesis.	IL2RA IL2RB	9.07e-06	3	61	2	10784587
Pubmed	Induction of interleukin-2 receptor alpha (IL-2Ralpha) expression by interleukin-2: important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites.	IL2RA IL2RB	9.07e-06	3	61	2	12231477
Pubmed	Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.	IL2RA IL2RB	9.07e-06	3	61	2	23418630
Pubmed	Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.	IL2RA IL2RB	9.07e-06	3	61	2	28678791
Pubmed	CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.	RUNX1T1 CBFA2T3	9.07e-06	3	61	2	9790752
Pubmed	Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains.	FSTL3 MSTN	9.07e-06	3	61	2	12595574
Pubmed	Liver Injury and Elevated Levels of Interleukins, Interleukin-2 Receptor, and Interleukin-6 Predict the Severity in Patients With COVID-19.	IL2RA IL2RB	9.07e-06	3	61	2	34970527
Pubmed	Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.	IL2RA IL2RB	9.07e-06	3	61	2	2303462
Pubmed	Lymphokine regulation of activation-induced apoptosis in T cells of IL-2 and IL-2R beta knockout mice.	IL2RA IL2RB	9.07e-06	3	61	2	9636694
Pubmed	Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development.	IL2RA IL2RB	9.07e-06	3	61	2	8547641
Pubmed	Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review.	IL2RA IL2RB	9.07e-06	3	61	2	28497365
Pubmed	Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein.	IL2RA IL2RB	9.07e-06	3	61	2	1394441
Pubmed	Oligomerization of IL-2Ralpha.	IL2RA IL2RB	9.07e-06	3	61	2	11886175
Pubmed	Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.	IL2RA IL2RB	1.81e-05	4	61	2	19139102
Pubmed	The interleukin-2 and interleukin-4 receptors studied by molecular modelling.	IL2RA IL2RB	1.81e-05	4	61	2	7529123
Pubmed	Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition.	IL2RA IL2RB	1.81e-05	4	61	2	23676143
Pubmed	Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development.	FSTL3 MSTN	1.81e-05	4	61	2	17878677
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	MUC5AC NOTCH3	1.81e-05	4	61	2	22691042
Pubmed	Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.	IL2RA IL2RB	1.81e-05	4	61	2	16477002
Pubmed	Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.	IL2RA IL2RB	1.81e-05	4	61	2	2315327
Pubmed	Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.	RASA2 RNF41	1.81e-05	4	61	2	34270706
Pubmed	CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.	IL2RA IL2RB	1.81e-05	4	61	2	15105501
Pubmed	ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.	RUNX1T1 CBFA2T3	1.81e-05	4	61	2	16966434
Pubmed	Effects of pre-exercise feeding on serum hormone concentrations and biomarkers of myostatin and ubiquitin proteasome pathway activity.	FSTL3 MSTN	1.81e-05	4	61	2	22476926
Pubmed	Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.	IL2RA IL2RB	1.81e-05	4	61	2	17371960
Pubmed	One year in review: the pathogenesis of rheumatoid arthritis.	CCN1 IL2RB	1.81e-05	4	61	2	26203933
Pubmed	Lymphocyte activation by HIV-1 envelope glycoprotein.	IL2RA IL2RB	1.81e-05	4	61	2	2843775
Pubmed	Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.	IL2RA IL2RB	1.81e-05	4	61	2	16293754
Pubmed	Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor.	IL2RA IL2RB	1.81e-05	4	61	2	8262055
Pubmed	Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.	IL2RA IL2RB	1.81e-05	4	61	2	15753210
Pubmed	Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.	IL2RA IL2RB	1.81e-05	4	61	2	22446627
Pubmed	Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity.	IL2RA IL2RB	1.81e-05	4	61	2	9360952
Pubmed	Interleukin-2 receptor beta and gamma chain dysregulation during the inhibition of CD4 T cell activation by human immunodeficiency virus-1 gp120.	IL2RA IL2RB	1.81e-05	4	61	2	9341758
Pubmed	Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease.	IL2RA IL2RB	1.81e-05	4	61	2	19471255
Pubmed	Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice.	FSTL3 MSTN	1.81e-05	4	61	2	18334608
Pubmed	Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.	RUNX1T1 CBFA2T3	1.81e-05	4	61	2	14703694
Pubmed	Interleukin-2 and its receptor complex (alpha, beta and gamma chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study.	IL2RA IL2RB	1.81e-05	4	61	2	14680494
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	ITGA11 EYS STAB2 CSMD1 LRP1B	2.67e-05	199	61	5	23382691
Pubmed	Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women.	FSTL3 MSTN	3.02e-05	5	61	2	22395277
Pubmed	An essential role for the IL-2 receptor in Treg cell function.	IL2RA IL2RB	3.02e-05	5	61	2	27595233
Pubmed	Cutting edge: JAK3 activation and rescue of T cells from HIV gp120-induced unresponsiveness.	IL2RA IL2RB	3.02e-05	5	61	2	9637477
Pubmed	Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.	IL2RA IL2RB	3.02e-05	5	61	2	7641685
Pubmed	Regional expression of MTG genes in the developing mouse central nervous system.	RUNX1T1 CBFA2T3	3.02e-05	5	61	2	19618476
Pubmed	Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.	RUNX1T1 CBFA2T3	3.02e-05	5	61	2	18586123
Pubmed	IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.	IL2RA IL2RB	3.02e-05	5	61	2	18990450
Pubmed	Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription.	RUNX1T1 CBFA2T3	3.02e-05	5	61	2	18039847
Pubmed	MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.	RUNX1T1 CBFA2T3 NOTCH3	4.49e-05	39	61	3	36064547
Pubmed	A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury.	HAVCR1 TNFRSF10C	4.52e-05	6	61	2	37460623
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC19 MUC5AC	4.52e-05	6	61	2	19110483
Pubmed	Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.	RUNX1T1 CBFA2T3	4.52e-05	6	61	2	23251453
Pubmed	IL-18-induced expression of high-affinity IL-2R on murine NK cells is essential for NK-cell IFN-γ production during murine Plasmodium yoelii infection.	IL2RA IL2RB	4.52e-05	6	61	2	26420375
Pubmed	Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma.	ITGA11 CCN1	4.52e-05	6	61	2	8635876
Pubmed	Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.	IL2RA IL2RB	4.52e-05	6	61	2	19923221
Pubmed	An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.	IL2RA IL2RB	4.52e-05	6	61	2	17664294
Pubmed	The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15.	IL2RA IL2RB	4.52e-05	6	61	2	18390713
Pubmed	Regulation of muscle mass by follistatin and activins.	FSTL3 MSTN	6.32e-05	7	61	2	20810712
Pubmed	Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation.	IL2RA IL2RB	6.32e-05	7	61	2	7736574
Pubmed	The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies.	RUNX1T1 CBFA2T3	6.32e-05	7	61	2	12242670
Pubmed	Genetic mapping of the interleukin 1 receptor alpha and beta chain genes in the mouse.	IL2RA IL2RB	8.42e-05	8	61	2	8597644
Pubmed	Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.	IL2RA IL2RB	8.42e-05	8	61	2	10602027
Pubmed	A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells.	IL2RA IL2RB	8.42e-05	8	61	2	18566388
Pubmed	ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).	IL2RA IL2RB	8.42e-05	8	61	2	21217760
Pubmed	ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.	RUNX1T1 CBFA2T3	8.42e-05	8	61	2	11533236
Pubmed	Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.	SLCO5A1 EYS ISM1	1.33e-04	56	61	3	23934736
Pubmed	Interleukin-2 critically regulates bone marrow erythropoiesis and prevents anemia development.	IL2RA IL2RB	1.35e-04	10	61	2	26404745
Pubmed	Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.	IL2RA IL2RB	1.35e-04	10	61	2	10825200
Pubmed	IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.	IL2RA IL2RB	1.35e-04	10	61	2	17182565
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELE CSMD1 IL2RA CFHR4	6.72e-06	57	39	4	1179
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS20 ADAMTS14	7.58e-04	19	39	2	50
GeneFamily	CD molecules\|Mucins	MUC19 MUC5AC	9.28e-04	21	39	2	648
GeneFamily	Zinc fingers MYND-type	RUNX1T1 CBFA2T3	9.28e-04	21	39	2	87
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	SELE HAVCR1 TNFRSF10C IL2RA IL2RB	1.50e-03	394	39	5	471
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL2RA IL2RB	3.70e-03	42	39	2	602
GeneFamily	Fibronectin type III domain containing	MYLK FNDC3A ANKFN1	4.92e-03	160	39	3	555
Coexpression	NABA_MATRISOME	THSD4 EYS SPAM1 OIT3 FSTL3 CCN1 WNT8A ISM1 BRINP2 MUC19 ADAMTS20 PLXND1 ADAMTS14 MSTN MUC5AC	7.16e-09	1026	60	15	M5889
Coexpression	NABA_MATRISOME	THSD4 SPAM1 OIT3 FSTL3 CCN1 WNT8A ISM1 BRINP2 MUC19 ADAMTS20 PLXND1 ADAMTS14 MSTN MUC5AC	4.71e-08	1008	60	14	MM17056
Coexpression	NABA_MATRISOME_ASSOCIATED	SPAM1 FSTL3 WNT8A ISM1 BRINP2 MUC19 ADAMTS20 PLXND1 ADAMTS14 MSTN MUC5AC	7.99e-07	738	60	11	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	SPAM1 FSTL3 WNT8A ISM1 BRINP2 MUC19 ADAMTS20 PLXND1 ADAMTS14 MSTN MUC5AC	9.47e-07	751	60	11	M5885
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#1_top-relative-expression-ranked_1000	SLCO5A1 SSH1 ADAMTS20 RUNX1T1 TENM2	1.91e-05	120	58	5	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k1
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 ITGA11 SYCP2 FSTL3 CCN1 CBFA2T3 NOTCH3	5.95e-09	183	61	7	b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 ITGA11 CSMD1 TENM2 NOTCH3 ITPR1	2.12e-07	186	61	6	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 MYLK ISM1 RUNX1T1 TENM2 NOTCH3	2.47e-07	191	61	6	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ITGA11 MYLK CCN1 CSMD1 TENM2 NOTCH3	3.24e-07	200	61	6	9169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 ITGA11 CSMD1 TENM2 NOTCH3	3.75e-06	171	61	5	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE MYLK NRXN2 IL2RA NOTCH3	3.96e-06	173	61	5	d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HAVCR1 FSTL3 NRXN2 MUC5AC NOTCH3	3.96e-06	173	61	5	4f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HAVCR1 FSTL3 NRXN2 MUC5AC NOTCH3	3.96e-06	173	61	5	9bbea566964281f47bf75d665b7d69ba8326e207
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE MYLK NRXN2 IL2RA NOTCH3	3.96e-06	173	61	5	3c852ffe22f4a5b632463086b08c669310684e80
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ITGA11 MYLK RUNX1T1 MUC5AC NOTCH3	3.96e-06	173	61	5	5416b092321c7d9b63f0418c60f2402a138355bf
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE MYLK BRINP2 CBFA2T3 NOTCH3	4.08e-06	174	61	5	a0a059bb2a64d7011e206db2ebcdf3eb655a925a
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE MYLK BRINP2 CBFA2T3 NOTCH3	4.08e-06	174	61	5	7cd6f9103133f8d7b90f9ff4b3b0b078cf554542
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	THSD4 FSTL3 CCN1 EMP2 TACSTD2	4.19e-06	175	61	5	bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell	facs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK BRINP2 LRP1B HEATR3 NOTCH3	4.19e-06	175	61	5	d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCell	facs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK BRINP2 LRP1B HEATR3 NOTCH3	4.19e-06	175	61	5	cf15465855602ba135752c18755e3e058dbd42ec
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-Alox5+_lymphocyte-Alox5+_lymphocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 STC2 NIPAL1 IL2RA IL2RB	4.43e-06	177	61	5	b7cfa3776f58377e35830780650d236b5cceecee
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-Alox5+_lymphocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 STC2 NIPAL1 IL2RA IL2RB	4.43e-06	177	61	5	1730e640986e50943bd781b7d949bcc5b7c12dde
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 MYLK BRINP2 ADAMTS14 NOTCH3	4.68e-06	179	61	5	8da6863edc756540bb097cc7221c1408640d9bb4
ToppCell	droplet-Marrow-nan-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAVCR1 NRXN2 FNDC3A CBFA2T3 ITPR1	4.68e-06	179	61	5	dcaf2191134a586d50ebaf67dcf5b815b54a722b
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 MYLK BRINP2 ADAMTS14 NOTCH3	4.68e-06	179	61	5	f39c13c99a07d009cc677e363ffe089089c64916
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAVCR1 NRXN2 FNDC3A CBFA2T3 ITPR1	4.68e-06	179	61	5	87a69f9f83b8f0c028a4874acb238f2e079bf51f
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 MYLK BRINP2 IL2RA NOTCH3	4.81e-06	180	61	5	a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 MYLK BRINP2 IL2RA NOTCH3	4.81e-06	180	61	5	63a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 FSTL3 STC2 CBFA2T3 NOTCH3	5.21e-06	183	61	5	4060d979948e1dd7507977629a7fbdfa4ca65bb6
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 FSTL3 STC2 CBFA2T3 NOTCH3	5.21e-06	183	61	5	0d44a978221cf3f733704bf11863502805fba733
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYCP2 STAB2 ADAMTS20 CSMD1 LRP1B	5.35e-06	184	61	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYCP2 STAB2 ADAMTS20 CSMD1 LRP1B	5.35e-06	184	61	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYCP2 STAB2 ADAMTS20 CSMD1 LRP1B	5.35e-06	184	61	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Heart-RA-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE MYLK NRXN2 CBFA2T3 NOTCH3	5.50e-06	185	61	5	c4ef8d9f8b9769e887daac4efd9dc05738b28ae2
ToppCell	facs-Heart-RA-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELE MYLK NRXN2 CBFA2T3 NOTCH3	5.50e-06	185	61	5	10ddf38d908525b4258f9d2da8be4c56ebc08ff4
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYCP2 STAB2 OIT3 NRXN2 PLXND1	5.64e-06	186	61	5	2cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPAM1 MUC19 ADAMTS20 CSMD1 LRP1B	5.64e-06	186	61	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYCP2 STAB2 OIT3 NRXN2 PLXND1	5.64e-06	186	61	5	90d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD4 ITGA11 CSMD1 TENM2 NOTCH3	5.64e-06	186	61	5	a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell	Mesenchymal_cells-Adipo-CAR\|World / Lineage and Cell class	MYLK CCN1 ISM1 EMP2 CSMD1	5.64e-06	186	61	5	6ca8ce7ced91d6308b7c056032ffec1b37c974bf
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ITGA11 MYLK ISM1 ADAMTS14 ANKFN1	5.94e-06	188	61	5	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ITGA11 MYLK ISM1 ADAMTS14 NOTCH3	6.10e-06	189	61	5	f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell	droplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYCP2 STAB2 OIT3 NRXN2 PLXND1	6.10e-06	189	61	5	ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 FSTL3 CCN1 CBFA2T3 NOTCH3	6.42e-06	191	61	5	9431ffd6b758f756609d9057de2023596e22b5d4
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDM1 NIPAL1 FNDC3A RUNX1T1 ITPR1	6.42e-06	191	61	5	657297cd19d05a7e7bb74fc3a086fbd95f47aae4
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 OIT3 NRXN2 PLXND1 CBFA2T3	6.58e-06	192	61	5	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	Fibroblast-D_(Pericyte)\|World / shred on cell class and cell subclass (v4)	THSD4 ITGA11 MYLK CBFA2T3 NOTCH3	6.58e-06	192	61	5	8c13c351fcc3d88e8c2ffa017e71ff6272cc6fac
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 OIT3 NRXN2 PLXND1 CBFA2T3	6.58e-06	192	61	5	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK FSTL3 CCN1 NOTCH3	6.75e-06	193	61	5	9a2c1711dec9dd8c8313bcf25bb888ac8e86c3f3
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK CCN1 NRXN2 ISM1 RUNX1T1	6.75e-06	193	61	5	fa45042d30f9cfeed10e23270a78f18551219cfa
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK FSTL3 CCN1 NOTCH3	6.75e-06	193	61	5	7c7aa5e2124830d0fa1df11b6413ec6cf780aad0
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK CCN1 NRXN2 ISM1 RUNX1T1	6.75e-06	193	61	5	ab511ea9e09216a965b3ae5a94f8c3c1ae33d944
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ITGA11 MYLK CCN1 RUNX1T1	6.92e-06	194	61	5	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ITGA11 MYLK CCN1 RUNX1T1	6.92e-06	194	61	5	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK FSTL3 CCN1 NOTCH3	6.92e-06	194	61	5	aaecde88bd54134a938e76cdf059c1c2653e4e77
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ITGA11 MYLK CCN1 ISM1	7.10e-06	195	61	5	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GAB4 MUC19 TNFRSF10C CSMD1 LRP1B	7.10e-06	195	61	5	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRXN2 ISM1 ARMCX6 CBFA2T3 NOTCH3	7.10e-06	195	61	5	4a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GAB4 MUC19 TNFRSF10C CSMD1 LRP1B	7.10e-06	195	61	5	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ITGA11 MYLK CCN1 ISM1	7.10e-06	195	61	5	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK FSTL3 CCN1 NOTCH3	7.10e-06	195	61	5	56e7cd980f8fc2dae842e6a7bd919d4b41cebbbb
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRXN2 ISM1 ARMCX6 CBFA2T3 NOTCH3	7.10e-06	195	61	5	7a32a8535c29b819dacba901d0658280a2631c94
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK FSTL3 CCN1 NOTCH3	7.10e-06	195	61	5	a28a504c69bc4dda7de023e1b4ea4f62390b158e
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK NRXN2 EMP2 CSMD1 RUNX1T1	7.28e-06	196	61	5	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK NRXN2 EMP2 CSMD1 RUNX1T1	7.28e-06	196	61	5	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ITGA11 MYLK CCN1 RUNX1T1	7.28e-06	196	61	5	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ITGA11 MYLK RUNX1T1 NOTCH3	7.28e-06	196	61	5	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	PND28-Mesenchymal\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYLK FSTL3 CCN1 ISM1 NOTCH3	7.28e-06	196	61	5	119265efd2219f328d8152dbee52af8327aec89c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ITGA11 MYLK RUNX1T1 NOTCH3	7.28e-06	196	61	5	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK FSTL3 CCN1 NOTCH3	7.28e-06	196	61	5	4740ef6e428f1ccc81fc98c3b868afd38ce60535
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK FSTL3 CCN1 NOTCH3	7.46e-06	197	61	5	1a6b2ca94a4634c24cd95481576c955b20000a5f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ITGA11 MYLK CCN1 RUNX1T1	7.46e-06	197	61	5	80e153790cef37b743e22a7370ff5b3a6abf147d
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK CCN1 ISM1 NOTCH3	7.46e-06	197	61	5	8c728cd3c0382c4f3e4b78647b6e1447bb40ace1
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 MYLK CCN1 ISM1 NOTCH3	7.64e-06	198	61	5	b258f672529fb2c03e62e2696d335043c4963280
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	THSD4 CCN1 EMP2 MSTN NOTCH3	7.83e-06	199	61	5	e19b296d583f8bad3b66ee998a8153634d6fe09e
ToppCell	Biopsy_Control_(H.)-Epithelial-KRT5-/KRT17+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	FSTL3 CCN1 TNFRSF10C TACSTD2 NOTCH3	7.83e-06	199	61	5	3b1f56c8b40bb36922a31d2d440a8c468a8aa3f1
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	THSD4 CCN1 EMP2 MSTN NOTCH3	7.83e-06	199	61	5	801887db51ac5dc5b068808ff75e3a46643398e9
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	MYLK CSMD1 TENM2 NOTCH3 ITPR1	8.02e-06	200	61	5	a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MYLK CSMD1 TENM2 NOTCH3 ITPR1	8.02e-06	200	61	5	c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte\|LPS_only / Treatment groups by lineage, cell group, cell type	MYLK CCN1 CSMD1 TENM2 NOTCH3	8.02e-06	200	61	5	8c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3\|Control_saline / Treatment groups by lineage, cell group, cell type	ITGA11 MYLK CCN1 TENM2 NOTCH3	8.02e-06	200	61	5	b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_only / Treatment groups by lineage, cell group, cell type	MYLK CCN1 CSMD1 TENM2 NOTCH3	8.02e-06	200	61	5	7c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD4 STC2 RNF41 RUNX1T1	4.44e-05	143	61	4	b4ed3855652fdf32f97cb7c18cab4f4f4c24d5c7
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CSMD1 CBFA2T3 TENM2 NOTCH3	4.81e-05	146	61	4	2ac9b487a7991fdc15444aeb93533030e09825bb
ToppCell	facs-Marrow-KLS-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FSTL3 NRXN2 KRTAP26-1 ADAMTS14	6.38e-05	157	61	4	5d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA11 ISM1 CBFA2T3 ITPR1	6.38e-05	157	61	4	f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell	facs-Marrow-KLS-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FSTL3 NRXN2 KRTAP26-1 ADAMTS14	6.38e-05	157	61	4	ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	EYS CSMD1 ANKFN1 TENM2	6.70e-05	159	61	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STC2 BRINP2 IL2RB LRP1B	7.20e-05	162	61	4	15d5d31a75e26bcd41919a00300c68e9f00f0002
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	STAB2 STC2 ADAMTS14 IL2RB	7.20e-05	162	61	4	04ccd3d216f8f41afd3434a61264f03d6324db35
ToppCell	368C-Myeloid-Dendritic-cDC1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CBFA2T3 TACSTD2 HEATR3 NOTCH3	7.38e-05	163	61	4	299ac2463b7f58eee419d822a2a2d64b973d87e9
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3\|Striatum / BrainAtlas - Mouse McCarroll V32	THSD4 MYLK FSTL3 NOTCH3	7.55e-05	164	61	4	e24b06a14565f7798ac50c2fe3f34d4547b9000e
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAVCR1 FSTL3 NRXN2 TACSTD2	8.10e-05	167	61	4	1248f809afbcccb42ce9e29cfe6fa1f6f6b65005
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAVCR1 FSTL3 NRXN2 TACSTD2	8.10e-05	167	61	4	a66552667aa6e8992c159df27a57c2e8ae14a9ce
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	MYLK CCN1 IL2RB NOTCH3	8.10e-05	167	61	4	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	BAL-Severe-cDC_5\|Severe / Compartment, Disease Groups and Clusters	HAVCR1 EMP2 NOTCH3 ITPR1	8.29e-05	168	61	4	857a80c217a5513553460798a625612031bc7bb7
ToppCell	Substantia_nigra-Endothelial-MURAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYLK CCN1 ADAMTS14 NOTCH3	8.29e-05	168	61	4	271a81c59a9a75bac6107c68fead03e7f35bc192
ToppCell	Substantia_nigra-Endothelial-MURAL-M1(Rgs5Acta2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MYLK CCN1 ADAMTS14 NOTCH3	8.29e-05	168	61	4	b220e732eb7b204fc263a9f2e8ddae6bf9fa98f4
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAVCR1 NRXN2 MUC5AC NOTCH3	8.48e-05	169	61	4	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCN1 ADAMTS14 RUNX1T1 CFHR4	8.48e-05	169	61	4	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_11\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLCO5A1 HAVCR1 CBFA2T3 TACSTD2	8.48e-05	169	61	4	e3410ccb3f85811c75694e286115803911169a2f
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-mature_NK_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL2RA IL2RB ANKFN1 LYPD8	8.88e-05	171	61	4	d322cc042a6f4b4aa8ef80ae977edbce9e266d48
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELE OIT3 PLXND1 TENM2	8.88e-05	171	61	4	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO5A1 MYLK ADAMTS14 NOTCH3	9.29e-05	173	61	4	2415b6ff49f334da570577d4e93484d024a3dbd5
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	FSTL3 CCN1 EMP2 TACSTD2	9.29e-05	173	61	4	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
Computational	Placenta genes.	MYLK FSTL3 CCN1 PLXND1 TNFRSF10C EMP2 RUNX1T1 TACSTD2 NOTCH3	9.46e-06	463	34	9	MODULE_38
Computational	Ovary genes.	SELE MYLK FSTL3 CCN1 PLXND1 EMP2 NOTCH3 ITPR1	1.45e-05	368	34	8	MODULE_1
Computational	Lung genes.	MYLK FSTL3 CCN1 PLXND1 EMP2 TACSTD2 NOTCH3 ITPR1	4.76e-05	434	34	8	MODULE_5
Computational	Genes in the cancer module 67.	SSH1 NRXN2 RUNX1T1 LRP1B HEATR3	6.78e-04	227	34	5	MODULE_67
Disease	uterine fibroid	ITGA11 NIPAL1 FNDC3A CSMD1 HEATR3 ITPR1	2.64e-06	199	58	6	EFO_0000731
Disease	Juvenile pauciarticular chronic arthritis	IL2RA IL2RB	7.92e-05	7	58	2	C2931171
Disease	triacylglycerol 58:6 measurement	LRP1B TENM2	1.06e-04	8	58	2	EFO_0010440
Disease	thoracic aortic aneurysm (is_implicated_in)	THSD4 MYLK	2.06e-04	11	58	2	DOID:14004 (is_implicated_in)
Disease	NG-monomethyl-arginine measurement	CSMD1 ANKFN1	2.06e-04	11	58	2	EFO_0010510
Disease	COVID-19 (is_marker_for)	SELE IL2RA IL2RB	2.63e-04	63	58	3	DOID:0080600 (is_marker_for)
Disease	phosphocreatine measurement	ADAMTS20 TENM2	2.92e-04	13	58	2	EFO_0010521
Disease	Sjogren's syndrome (implicated_via_orthology)	MUC19 IL2RA	5.07e-04	17	58	2	DOID:12894 (implicated_via_orthology)
Disease	serum IgG glycosylation measurement	ITGA11 EYS STAB2 CSMD1 ANKFN1 LRP1B	5.59e-04	523	58	6	EFO_0005193
Disease	lung cancer	CSMD1 TENM2	7.78e-04	21	58	2	MONDO_0008903
Disease	obesity (implicated_via_orthology)	ADAMTS20 PLXND1 NOTCH3 ITPR1	8.55e-04	215	58	4	DOID:9970 (implicated_via_orthology)
Disease	glomerular filtration rate, renal transplant outcome measurement, donor genotype effect measurement	STC2 CSMD1	8.55e-04	22	58	2	EFO_0005199, EFO_0005208, EFO_0007892
Disease	sensory peripheral neuropathy, remission	CSMD1 RUNX1T1	9.36e-04	23	58	2	EFO_0009785, MONDO_0002321
Disease	periodontitis	THSD4 CSMD1 LRP1B TENM2	9.79e-04	223	58	4	EFO_0000649
Disease	airway responsiveness measurement	CSMD1 ANKFN1	1.02e-03	24	58	2	EFO_0006897
Disease	Sjogren's syndrome (is_marker_for)	MUC19 MUC5AC	1.02e-03	24	58	2	DOID:12894 (is_marker_for)
Disease	Periodontal Pocket	ISM1 ADAMTS14	1.11e-03	25	58	2	EFO_1001393
Disease	ceramide measurement	SLCO5A1 EYS ISM1 NIPAL1	1.19e-03	235	58	4	EFO_0010222
Disease	R-6-hydroxywarfarin to R-warfarin ratio measurement	THSD4 EYS AHCY	1.20e-03	106	58	3	EFO_0803333
Disease	lower face morphology measurement	THSD4 ITGA11 LRP1B	1.31e-03	109	58	3	EFO_0010948
Disease	peptide measurement	SPAM1 CSMD1 IL2RB	1.31e-03	109	58	3	EFO_0010520
Disease	lumbar disc degeneration	EYS CSMD1	1.39e-03	28	58	2	EFO_0004994
Disease	preterm premature rupture of the membranes, spontaneous preterm birth	FNDC3A ADAMTS14	1.39e-03	28	58	2	EFO_0006917, MONDO_0012511
Disease	Drug habituation	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C0013170
Disease	Substance-Related Disorders	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C0236969
Disease	Drug abuse	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C0013146
Disease	Drug Use Disorders	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C0013222
Disease	Drug Dependence	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C1510472
Disease	Substance Dependence	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C0038580
Disease	Substance Use Disorders	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C0029231
Disease	Prescription Drug Abuse	THSD4 CSMD1 TENM2	1.52e-03	115	58	3	C4316881
Disease	Substance abuse problem	THSD4 CSMD1 TENM2	1.56e-03	116	58	3	C0740858
Disease	L-Selectin measurement	SELE IL2RB	1.70e-03	31	58	2	EFO_0008202
Disease	eating disorder	EMP2 CSMD1	1.81e-03	32	58	2	EFO_0005203
Disease	severe acute respiratory syndrome, COVID-19	THSD4 EYS CSMD1 LRP1B TENM2	1.85e-03	447	58	5	EFO_0000694, MONDO_0100096
Disease	carotid artery intima media thickness	THSD4 SLCO5A1 CBFA2T3 LRP1B TENM2	1.90e-03	450	58	5	EFO_0007117
Disease	disease recurrence, unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement	THSD4 LRP1B	1.93e-03	33	58	2	EFO_0003761, EFO_0004952, EFO_0008343, MONDO_0004985, MONDO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
TCLANLTWSGIQTEC	CSMD1	3256	Q96PZ7
GQKCIVQTTSWSQCS	CCN1	226	O00622
SNFTCQTEGACWASV	ACVR1C	36	Q8NER5
TLNVHDGCVNTICWN	DCAF6	46	Q58WW2
NTWSAQNCKNGSCVL	ARMCX6	111	Q7L4S7
AWSQCSATCGEGIQQ	ADAMTS14	976	Q8WXS8
SWNECSVTCGSGVQQ	ADAMTS20	1481	P59510
GMTCNSCVWTIEQQI	ATP7A	16	Q04656
LNGNWLCCQETGENT	RASA2	721	Q15283
SCTASNAQGQLSCSW	MYLK	486	Q15746
NVPVCLCSTNWSGTQ	LRP1B	4411	Q9NZR2
WAGNTCNQSVSCLNN	EYS	2926	Q5T1H1
AWQQCSSEQNHQPCS	IRF1-AS1	101	Q8N8D9
CNEVNSVNCNTSWKI	ITPR1	206	Q14643
NQQEDSSESCWNCGR	RUNX1T1	506	Q06455
QQTILQVSCGNWHCL	HERC3	136	Q15034
WCSQQHSCVSNQSRC	PLXND1	726	Q9Y4D7
ASFNGNCCLWNTTVE	OIT3	106	Q8WWZ8
NECTCIKGSWSCTQN	MUC19	1256	Q7Z5P9
IKGSWSCTQNECQTI	MUC19	1261	Q7Z5P9
SLQTWCSCVAGQPIQ	FAM205A	356	Q6ZU69
SLQTWCSCVAGQPIQ	FAM205BP	86	Q63HN1
NQILSDSNCCWDVSS	MDM1	361	Q8TC05
TEESCANQGVCLQQW	NRXN2	1101	Q9P2S2
ANQGVCLQQWDGFTC	NRXN2	1106	Q9P2S2
VCVNGWTGESCSQNI	NOTCH3	301	Q9UM47
AQSLQCTSSGNWDNE	SELE	281	P16581
QNCSWTVCSINGTLY	MUC5AC	5376	P98088
LTDEANTSCNIWGNS	ITGA11	1026	Q9UKX5
INQQEDSSESCWNCG	CBFA2T3	546	O75081
ADVWRICTNNTNCTV	EMP2	36	P54851
NETVNVLWNICECSS	HEATR3	161	Q7Z4Q2
GVCWLQQGQEATCSL	FSTL3	36	O95633
NWQSRTCVCVLTGHN	COPA	121	P53621
QVTCRSATCAQVNWE	FNDC3A	766	Q9Y2H6
NEWVQSICQICGFRQ	GAB4	141	Q2WGN9
CVWSQDGALQDTSCQ	IL2RB	46	P14784
SITCLQNGWSTQPIC	CFHR4	131	Q92496
WDNQCQCTSSATRNT	IL2RA	76	P01589
SCVQCNSWEKSCVNS	LYPD8	21	Q6UX82
LPSSCQSQTWQLVTC	KRTAP16-1	31	A8MUX0
QSQTWQLVTCQDSCG	KRTAP16-1	36	A8MUX0
SQDHTWVTDNCQETC	KRTAP26-1	46	Q6PEX3
CQEQGVCIRKNWNSS	SPAM1	381	P38567
ACITQWFSQQQTCPV	RNF41	41	Q9H4P4
GAEVQWSSCNIFSTQ	AHCY	71	P23526
WSVCSVTCGNGNQKR	ISM1	226	B1AKI9
LVCPNSSQAWCEITN	NIPAL1	21	Q6NVV3
ARQCNQTSVCWCVNS	TACSTD2	116	P09758
EGLCNACTWRQNTKS	MSTN	36	O14793
SCSLFTCQNGIVWTN	HAVCR1	51	Q96D42
TTCMLWQQECGVQGS	SLCO5A1	711	Q9H2Y9
AGGVNWSNVTCQATQ	SECISBP2L	306	Q93073
TLGQNSWQCVCQTGW	TENM2	821	Q9NT68
ESCISSEQSCINEWN	SSH1	211	Q8WYL5
TNVDAAAQCQNWTIT	BRINP2	616	Q9C0B6
CSSAASNSINWNCRV	ANKFN1	56	Q8N957
SWRQDNLNGTDCQGC	PRY	11	O14603
QAAGTEASQTIWVNC	UBTFL6	351	P0CB48
HSVQVQCEQNWGSLC	STC2	191	O76061
ACWTPVTNIELCNNQ	SYCP2	616	Q9BX26
CACEQSSGWTSLVQR	ZNF408	121	Q9H9D4
VQVSNCTSWDDIQCV	TNFRSF10C	136	O14798
QSTSSGVWSCVCQEG	STAB2	971	Q8WWQ8
NCNSSNNICWTEKGR	TMEM168	596	Q9H0V1
SGSCSIQTCWLQLAE	WNT8A	186	Q9H1J5
WSQCSIECGSGTQQR	THSD4	861	Q6ZMP0