Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A CACNA1B PKD2

4.09e-0646143GO:0005245
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B

1.64e-059142GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B

1.64e-059142GO:0099626
GeneOntologyMolecularFunctionphosphatase binding

CACNA1B FLT4 PPP1R35 FMR1

2.69e-05264144GO:0019902
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B

4.13e-0514142GO:0008331
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A CACNA1B PKD2

9.10e-05129143GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1A CACNA1B PKD2

1.45e-04151143GO:0015085
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1A CACNA1B PKD2

1.48e-04152143GO:0022843
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1A CACNA1B PKD2

2.52e-04182143GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1A CACNA1B PKD2

2.60e-04184143GO:0022832
GeneOntologyMolecularFunctionprotein phosphatase binding

CACNA1B FLT4 FMR1

3.83e-04210143GO:0019903
GeneOntologyMolecularFunctiongated channel activity

CACNA1A CACNA1B PKD2

1.47e-03334143GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1A CACNA1B PKD2

1.59e-03343143GO:0005261
GeneOntologyMolecularFunctionprotein homodimerization activity

FXR2 FLT4 FMR1 PKD2

1.99e-03815144GO:0042803
GeneOntologyMolecularFunctionamyloid-beta binding

CACNA1A CACNA1B

2.26e-03102142GO:0001540
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1A CACNA1B PKD2

3.64e-03459143GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1A CACNA1B PKD2

3.77e-03465143GO:0046873
GeneOntologyMolecularFunctionchannel activity

CACNA1A CACNA1B PKD2

5.30e-03525143GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1A CACNA1B PKD2

5.33e-03526143GO:0022803
GeneOntologyMolecularFunctiontransmembrane transporter binding

FMR1 PKD2

6.27e-03172142GO:0044325
GeneOntologyMolecularFunctionprotein dimerization activity

FXR2 FLT4 FMR1 PKD2

8.11e-031205144GO:0046983
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1A CACNA1B PKD2

8.66e-03627143GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1A CACNA1B PKD2

1.01e-02664143GO:0008324
GeneOntologyMolecularFunctioncalcium ion binding

CACNA1B RASGRP4 PKD2

1.40e-02749143GO:0005509
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1A CACNA1B PKD2

1.45e-02758143GO:0015318
GeneOntologyMolecularFunctionmRNA 3'-UTR binding

FXR2 FMR1

1.55e-02276142GO:0003730
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1A CACNA1B PKD2

1.64e-02793143GO:0015075
GeneOntologyMolecularFunctionamide binding

CACNA1A CACNA1B

1.81e-02299142GO:0033218
GeneOntologyMolecularFunctionmicrotubule binding

CCDC61 FMR1

1.91e-02308142GO:0008017
GeneOntologyMolecularFunctionpeptide binding

CACNA1A CACNA1B

2.03e-02318142GO:0042277
GeneOntologyBiologicalProcessregulation of translation at presynapse, modulating synaptic transmission

FXR2 FMR1

1.28e-063142GO:0099577
GeneOntologyBiologicalProcessregulation of translation at presynapse

FXR2 FMR1

1.28e-063142GO:0140244
GeneOntologyBiologicalProcessregulation of translation at synapse, modulating synaptic transmission

FXR2 FMR1

1.54e-059142GO:0099547
GeneOntologyBiologicalProcesspositive regulation of long-term neuronal synaptic plasticity

FXR2 FMR1

2.34e-0511142GO:0048170
GeneOntologyBiologicalProcessregulation of translation at synapse

FXR2 FMR1

3.32e-0513142GO:0140243
GeneOntologyBiologicalProcesscalcium ion import

CACNA1A CACNA1B PKD2

3.64e-0598143GO:0070509
GeneOntologyBiologicalProcessregulation of neurotransmitter secretion

CACNA1A CACNA1B FMR1

6.35e-05118143GO:0046928
GeneOntologyBiologicalProcesssynaptic vesicle exocytosis

CACNA1A CACNA1B FMR1

7.53e-05125143GO:0016079
GeneOntologyBiologicalProcessregulation of neurotransmitter transport

CACNA1A CACNA1B FMR1

1.08e-04141143GO:0051588
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

CACNA1A CACNA1B FMR1 PKD2

1.11e-04392144GO:0070588
GeneOntologyBiologicalProcessmicrotubule organizing center organization

CCDC61 PPP1R35 PKD2

2.18e-04179143GO:0031023
GeneOntologyBiologicalProcesssignal release from synapse

CACNA1A CACNA1B FMR1

2.80e-04195143GO:0099643
GeneOntologyBiologicalProcessneurotransmitter secretion

CACNA1A CACNA1B FMR1

2.80e-04195143GO:0007269
GeneOntologyBiologicalProcesscalcium ion transport

CACNA1A CACNA1B FMR1 PKD2

3.01e-04509144GO:0006816
GeneOntologyBiologicalProcessregulation of long-term neuronal synaptic plasticity

FXR2 FMR1

3.29e-0440142GO:0048169
GeneOntologyBiologicalProcessnegative regulation of calcium ion transmembrane transporter activity

FMR1 PKD2

3.46e-0441142GO:1901020
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

CACNA1A CACNA1B PKD2

3.84e-04217143GO:0097553
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

CACNA1A CACNA1B

4.74e-0448142GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

CACNA1A CACNA1B

4.74e-0448142GO:1902656
GeneOntologyBiologicalProcessresponse to pain

CACNA1A CACNA1B

5.35e-0451142GO:0048265
GeneOntologyBiologicalProcesscentriole assembly

CCDC61 PPP1R35

5.78e-0453142GO:0098534
GeneOntologyBiologicalProcessneurotransmitter transport

CACNA1A CACNA1B FMR1

6.43e-04259143GO:0006836
GeneOntologyBiologicalProcessnegative regulation of cation channel activity

FMR1 PKD2

6.45e-0456142GO:2001258
GeneOntologyBiologicalProcesssynaptic vesicle cycle

CACNA1A CACNA1B FMR1

6.80e-04264143GO:0099504
GeneOntologyBiologicalProcessresponse to amyloid-beta

CACNA1A CACNA1B

7.65e-0461142GO:1904645
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

CACNA1A CACNA1B FXR2 FMR1

8.19e-04663144GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

CACNA1A CACNA1B FXR2 FMR1

8.23e-04664144GO:0099177
GeneOntologyBiologicalProcessregulated exocytosis

CACNA1A CACNA1B FMR1

9.02e-04291143GO:0045055
GeneOntologyBiologicalProcesspresynaptic modulation of chemical synaptic transmission

FXR2 FMR1

9.22e-0467142GO:0099171
GeneOntologyBiologicalProcessnegative regulation of calcium ion transmembrane transport

FMR1 PKD2

9.78e-0469142GO:1903170
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

CACNA1A CACNA1B FMR1

1.20e-03321143GO:0099003
GeneOntologyBiologicalProcessregulation of calcium ion transport

CACNA1B FMR1 PKD2

1.22e-03323143GO:0051924
GeneOntologyBiologicalProcesscentrosome duplication

PPP1R35 PKD2

1.34e-0381142GO:0051298
GeneOntologyBiologicalProcessregulation of neuronal synaptic plasticity

FXR2 FMR1

1.41e-0383142GO:0048168
GeneOntologyBiologicalProcessnegative regulation of ion transmembrane transporter activity

FMR1 PKD2

1.55e-0387142GO:0032413
GeneOntologyBiologicalProcessregulation of calcium ion transmembrane transporter activity

FMR1 PKD2

1.73e-0392142GO:1901019
GeneOntologyBiologicalProcessnegative regulation of calcium ion transport

FMR1 PKD2

1.73e-0392142GO:0051926
GeneOntologyBiologicalProcesspositive regulation of gene expression

FXR2 FLT4 POLR3D FMR1 PKD2

1.97e-031446145GO:0010628
GeneOntologyBiologicalProcessnegative regulation of transporter activity

FMR1 PKD2

2.46e-03110142GO:0032410
GeneOntologyBiologicalProcesstransmission of nerve impulse

CACNA1A FMR1

2.55e-03112142GO:0019226
GeneOntologyBiologicalProcessnegative regulation of cation transmembrane transport

FMR1 PKD2

2.73e-03116142GO:1904063
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

CACNA1A CACNA1B FMR1 PKD2

2.77e-03922144GO:0098662
GeneOntologyBiologicalProcessexocytosis

CACNA1A CACNA1B FMR1

2.83e-03434143GO:0006887
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

CACNA1A CACNA1B FXR2 FMR1

2.87e-03931144GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

CACNA1A CACNA1B FXR2 FMR1

2.87e-03931144GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

CACNA1A CACNA1B FXR2 FMR1

2.96e-03939144GO:0099537
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1A CACNA1B FMR1 PKD2

3.00e-03942144GO:0098655
GeneOntologyBiologicalProcesspositive regulation of plasma membrane bounded cell projection assembly

PPP1R35 FMR1

3.06e-03123142GO:0120034
GeneOntologyBiologicalProcessnegative regulation of monoatomic ion transmembrane transport

FMR1 PKD2

3.11e-03124142GO:0034766
GeneOntologyBiologicalProcessmulticellular organismal response to stress

CACNA1A CACNA1B

3.21e-03126142GO:0033555
GeneOntologyBiologicalProcesssynaptic signaling

CACNA1A CACNA1B FXR2 FMR1

3.41e-03976144GO:0099536
GeneOntologyBiologicalProcessmembraneless organelle assembly

CCDC61 PPP1R35 FMR1

3.66e-03475143GO:0140694
GeneOntologyBiologicalProcessmetal ion transport

CACNA1A CACNA1B FMR1 PKD2

3.72e-031000144GO:0030001
GeneOntologyBiologicalProcessregulation of cation channel activity

FMR1 PKD2

3.84e-03138142GO:2001257
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

CACNA1A CACNA1B FMR1 PKD2

3.95e-031017144GO:0098660
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

CACNA1A CACNA1B

4.06e-03142142GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

CACNA1A CACNA1B

4.06e-03142142GO:0098659
GeneOntologyBiologicalProcessregulation of metal ion transport

CACNA1B FMR1 PKD2

4.06e-03493143GO:0010959
GeneOntologyBiologicalProcessmRNA transport

FXR2 FMR1

4.23e-03145142GO:0051028
GeneOntologyBiologicalProcessmicrotubule-based process

CCDC61 PPP1R35 FMR1 PKD2

4.56e-031058144GO:0007017
GeneOntologyBiologicalProcesspositive regulation of translation

FXR2 FMR1

4.57e-03151142GO:0045727
GeneOntologyBiologicalProcesscentrosome cycle

PPP1R35 PKD2

5.37e-03164142GO:0007098
GeneOntologyBiologicalProcessregulation of regulated secretory pathway

CACNA1A FMR1

5.43e-03165142GO:1903305
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

CACNA1A CACNA1B FMR1 PKD2

5.50e-031115144GO:0034220
GeneOntologyBiologicalProcessnegative regulation of monoatomic ion transport

FMR1 PKD2

5.82e-03171142GO:0043271
GeneOntologyBiologicalProcessRNA transport

FXR2 FMR1

6.09e-03175142GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

FXR2 FMR1

6.09e-03175142GO:0050657
GeneOntologyBiologicalProcessnegative regulation of transmembrane transport

FMR1 PKD2

6.09e-03175142GO:0034763
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1A CACNA1B

4.24e-0446142GO:0005891
GeneOntologyCellularComponentcation channel complex

CACNA1A CACNA1B PKD2

4.66e-04235143GO:0034703
GeneOntologyCellularComponentcalcium channel complex

CACNA1A CACNA1B

1.07e-0373142GO:0034704
GeneOntologyCellularComponentglutamatergic synapse

CACNA1A CACNA1B FXR2 FMR1

1.69e-03817144GO:0098978
GeneOntologyCellularComponentcytoplasmic stress granule

FXR2 FMR1

1.83e-0396142GO:0010494
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1A CACNA1B PKD2

1.84e-03378143GO:0034702
GeneOntologyCellularComponentdendrite

CACNA1A CACNA1B FXR2 FMR1

2.03e-03858144GO:0030425
GeneOntologyCellularComponentdendritic tree

CACNA1A CACNA1B FXR2 FMR1

2.05e-03860144GO:0097447
GeneOntologyCellularComponentpresynapse

CACNA1A CACNA1B FXR2 FMR1

2.28e-03886144GO:0098793
GeneOntologyCellularComponentpresynaptic active zone

CACNA1A CACNA1B

3.90e-03141142GO:0048786
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1A CACNA1B PKD2

4.61e-03523143GO:1902495
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

CACNA1B FMR1

4.69e-03155142GO:0098685
GeneOntologyCellularComponenttransporter complex

CACNA1A CACNA1B PKD2

5.31e-03550143GO:1990351
GeneOntologyCellularComponentciliary basal body

CCDC61 PKD2

7.32e-03195142GO:0036064
GeneOntologyCellularComponentsomatodendritic compartment

CACNA1A CACNA1B FXR2 FMR1

7.38e-031228144GO:0036477
GeneOntologyCellularComponentaxon terminus

CACNA1B FMR1

8.44e-03210142GO:0043679
GeneOntologyCellularComponentperikaryon

CACNA1A FMR1

9.47e-03223142GO:0043204
GeneOntologyCellularComponentcytoplasmic side of membrane

RASGRP4 PKD2

1.01e-02230142GO:0098562
GeneOntologyCellularComponentneuron projection terminus

CACNA1B FMR1

1.03e-02233142GO:0044306
GeneOntologyCellularComponentribosome

MRPS30 FXR2

1.34e-02267142GO:0005840
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

FXR2 FMR1

1.36e-02269142GO:0036464
GeneOntologyCellularComponentpresynaptic membrane

CACNA1A FMR1

1.43e-02277142GO:0042734
GeneOntologyCellularComponentribonucleoprotein granule

FXR2 FMR1

1.53e-02287142GO:0035770
MousePhenoabnormal thermal nociception

CACNA1A CACNA1B FXR2 FMR1

4.00e-06168104MP:0002733
MousePhenohypoalgesia

CACNA1A CACNA1B FXR2 FMR1

4.19e-06170104MP:0003043
MousePhenoabnormal pain threshold

CACNA1A CACNA1B FXR2 FMR1

2.50e-05267104MP:0001970
MousePhenoincreased thermal nociceptive threshold

CACNA1B FXR2 FMR1

5.17e-05108103MP:0001973
MousePhenoabnormal nerve fiber response

CACNA1A FMR1

5.50e-0516102MP:0003477
MousePhenoabnormal miniature excitatory postsynaptic currents

CACNA1A CACNA1B FMR1

6.40e-05116103MP:0004753
MousePhenoabnormal touch/ nociception

CACNA1A CACNA1B FXR2 FMR1

9.51e-05376104MP:0001968
MousePhenoimpaired conditioned place preference behavior

CACNA1B FMR1

1.48e-0426102MP:0009712
MousePhenoabnormal channel response

CACNA1A CACNA1B

2.40e-0433102MP:0003484
MousePhenoabnormal conditioned place preference behavior

CACNA1B FMR1

2.71e-0435102MP:0009711
MousePhenoincreased aggression towards mice

CACNA1B FMR1

3.72e-0441102MP:0001353
MousePhenohyporesponsive to tactile stimuli

CACNA1A CACNA1B

4.49e-0445102MP:0005498
MousePhenoabnormal pericardium morphology

FLT4 PPP1R35 PKD2

4.54e-04225103MP:0000288
MousePhenodecreased fear-related response

FXR2 FMR1

4.89e-0447102MP:0003460
MousePhenohydrops fetalis

FLT4 PKD2

6.22e-0453102MP:0002192
MousePhenoabnormal spatial learning

CACNA1B FXR2 FMR1

8.24e-04276103MP:0001463
MousePhenoenhanced behavioral response to xenobiotic

CACNA1A CACNA1B

1.05e-0369102MP:0009746
MousePhenoabnormal inhibitory postsynaptic currents

CACNA1A CACNA1B

1.08e-0370102MP:0002945
MousePhenoabnormal nonmotile primary cilium morphology

PPP1R35 PKD2

1.08e-0370102MP:0013205
MousePhenoabnormal aggression towards conspecific

CACNA1B FMR1

1.18e-0373102MP:0021115
MousePhenoabnormal fear-related response

FXR2 FMR1

1.21e-0374102MP:0003106
MousePhenoincreased aggression

CACNA1B FMR1

1.31e-0377102MP:0005655
MousePhenoabnormal nervous system electrophysiology

CACNA1A CACNA1B FMR1

1.37e-03329103MP:0002272
MousePhenoabnormal avoidance learning behavior

CACNA1B FMR1

1.94e-0394102MP:0001462
MousePhenoabnormal excitatory postsynaptic potential

CACNA1A CACNA1B

2.28e-03102102MP:0002912
MousePhenopericardial effusion

FLT4 PKD2

2.70e-03111102MP:0005312
MousePhenoabnormal social/conspecific interaction behavior

CACNA1A CACNA1B FMR1

2.78e-03421103MP:0002557
MousePhenoabnormal fear/anxiety-related behavior

CACNA1A CACNA1B FXR2 FMR1

2.83e-03919104MP:0002065
MousePhenoabnormal primary cilium morphology

PPP1R35 PKD2

2.84e-03114102MP:0013203
MousePhenoabnormal primitive node morphology

PPP1R35 PKD2

2.99e-03117102MP:0004066
MousePhenoabnormal aggression-related behavior

CACNA1B FMR1

3.51e-03127102MP:0002061
MousePhenoabnormal CNS synaptic transmission

CACNA1A CACNA1B FXR2 FMR1

3.65e-03985104MP:0002206
MousePhenoimpaired coordination

CACNA1A FXR2 FMR1

3.98e-03478103MP:0001405
MousePhenoreduced long-term potentiation

CACNA1B FMR1

4.31e-03141102MP:0001473
MousePhenoimpaired learning

CACNA1B FMR1

4.61e-03146102MP:0012315
MousePhenoabnormal spinal reflex

CACNA1A CACNA1B

4.74e-03148102MP:0012079
MousePhenoabnormal response to tactile stimuli

CACNA1A CACNA1B

4.74e-03148102MP:0005316
MousePhenoincreased exploration in new environment

CACNA1B FMR1

4.86e-03150102MP:0001415
MousePhenoabnormal synaptic transmission

CACNA1A CACNA1B FXR2 FMR1

4.93e-031070104MP:0003635
MousePhenoeffusion

FLT4 PKD2

4.99e-03152102MP:0021205
MousePhenoabnormal synaptic physiology

CACNA1A CACNA1B FXR2 FMR1

5.03e-031076104MP:0021009
MousePhenoconvulsive seizures

CACNA1A FMR1

5.06e-03153102MP:0000947
MousePhenopostnatal lethality

CACNA1A CACNA1B FLT4 PKD2

5.17e-031084104MP:0002082
DomainFXMRP1_C_core

FXR2 FMR1

1.34e-063132IPR022034
DomainAgenet

FXR2 FMR1

1.34e-063132PF05641
DomainAGENET_LIKE

FXR2 FMR1

1.34e-063132PS51641
DomainFXMRP1_C_core

FXR2 FMR1

1.34e-063132PF12235
DomainAgenet-like_dom

FXR2 FMR1

1.34e-063132IPR008395
DomainChannel_four-helix_dom

CACNA1A CACNA1B PKD2

7.54e-0657133IPR027359
Domain-

CACNA1A CACNA1B PKD2

7.54e-06571331.20.120.350
DomainCa_chan_IQ

CACNA1A CACNA1B

9.37e-067132PF08763
DomainGPHH

CACNA1A CACNA1B

9.37e-067132PF16905
DomainGPHH_dom

CACNA1A CACNA1B

9.37e-067132IPR031649
DomainVDCC_a1su_IQ

CACNA1A CACNA1B

9.37e-067132IPR014873
DomainCa_chan_IQ

CACNA1A CACNA1B

9.37e-067132SM01062
DomainVDCCAlpha1

CACNA1A CACNA1B

2.01e-0510132IPR002077
DomainKH_1

FXR2 FMR1

3.10e-0438132PF00013
Domain-

FXR2 FMR1

3.27e-04391323.30.1370.10
DomainKH

FXR2 FMR1

3.44e-0440132SM00322
DomainKH_dom

FXR2 FMR1

3.44e-0440132IPR004087
DomainKH_TYPE_1

FXR2 FMR1

3.79e-0442132PS50084
DomainKH_dom_type_1

FXR2 FMR1

4.16e-0444132IPR004088
DomainEF_HAND_2

CACNA1B RASGRP4 PKD2

4.87e-04231133PS50222
DomainEF_hand_dom

CACNA1B RASGRP4 PKD2

4.94e-04232133IPR002048
DomainIon_trans_dom

CACNA1A CACNA1B

2.76e-03114132IPR005821
DomainIon_trans

CACNA1A CACNA1B

2.76e-03114132PF00520
DomainEF-hand-dom_pair

CACNA1B PKD2

1.64e-02287132IPR011992
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B

2.48e-0511102M26913
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A CACNA1B

2.48e-0511102M47958
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B

2.48e-0511102MM14498
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1B

1.14e-0423102M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1A CACNA1B

1.35e-0425102M47948
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

CACNA1A CACNA1B

4.81e-0447102M19708
PathwayWP_SYNAPTIC_VESICLE_PATHWAY

CACNA1A CACNA1B

5.67e-0451102M39457
PathwayWP_MAPK_SIGNALING

CACNA1A CACNA1B RASGRP4

5.75e-04246103M39597
PathwayKEGG_TASTE_TRANSDUCTION

CACNA1A CACNA1B

5.89e-0452102M5785
PathwayKEGG_MAPK_SIGNALING_PATHWAY

CACNA1A CACNA1B RASGRP4

7.31e-04267103M10792
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

CACNA1A CACNA1B

1.16e-0373102MM16641
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A CACNA1B

4.60e-03147102MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A CACNA1B

4.85e-03151102M39329
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1A CACNA1B

6.67e-03178102M2890
PathwayWP_RAS_SIGNALING

RASGRP4 FLT4

7.12e-03184102M39764
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

CACNA1A CACNA1B

9.27e-03211102MM14502
Pubmed

On the aggregation properties of FMRP--a link with the FXTAS syndrome?

FXR2 FMR1

1.50e-07214221446998
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

1.50e-07214223426690
Pubmed

Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models.

FXR2 FMR1

1.50e-07214219244359
Pubmed

The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits.

FXR2 FMR1

1.50e-07214219193898
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

1.50e-07214238155373
Pubmed

Deficient Sleep in Mouse Models of Fragile X Syndrome.

FXR2 FMR1

1.50e-07214228919851
Pubmed

Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.

CACNA1A CACNA1B

1.50e-07214215050706
Pubmed

Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins.

FXR2 FMR1

1.50e-07214216675531
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

1.50e-07214223376566
Pubmed

The Fragile X proteins Fmrp and Fxr2p cooperate to regulate glucose metabolism in mice.

FXR2 FMR1

1.50e-07214225552647
Pubmed

LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation.

FXR2 FMR1

4.51e-07314238587486
Pubmed

The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.

FXR2 FMR1

4.51e-07314210888599
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B

4.51e-07314238996073
Pubmed

Fragile X-related proteins regulate mammalian circadian behavioral rhythms.

FXR2 FMR1

4.51e-07314218589395
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B

4.51e-07314229466725
Pubmed

Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.

FXR2 FMR1

4.51e-07314226051932
Pubmed

Spatial control of nucleoporin condensation by fragile X-related proteins.

FXR2 FMR1

4.51e-07314232706158
Pubmed

Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.

FXR2 FMR1

4.51e-07314212417522
Pubmed

The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.

FXR2 FMR1

4.51e-0731427489725
Pubmed

Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.

FXR2 FMR1

4.51e-0731428668200
Pubmed

Evidence that fragile X mental retardation protein is a negative regulator of translation.

FXR2 FMR1

4.51e-07314211157796
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B

4.51e-07314224523520
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1A CACNA1B

4.51e-07314224394417
Pubmed

Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.

FXR2 FMR1

4.51e-07314227770568
Pubmed

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.

CACNA1A CACNA1B

4.51e-07314229208674
Pubmed

Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer.

FXR2 FMR1

4.51e-07314232878499
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1A CACNA1B

4.51e-07314226507659
Pubmed

Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.

FXR2 FMR1

4.51e-07314226612855
Pubmed

Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.

FXR2 FMR1

4.51e-0731429259278
Pubmed

Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.

FXR2 FMR1

4.51e-07314219487368
Pubmed

FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.

FXR2 FMR1

4.51e-07314226109663
Pubmed

Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.

FXR2 FMR1

4.51e-07314220442204
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B

9.02e-07414232616470
Pubmed

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.

CACNA1A CACNA1B

9.02e-07414226283199
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B

9.02e-07414237141091
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1A CACNA1B

9.02e-07414231253182
Pubmed

Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex.

FXR2 FMR1

9.02e-07414210567518
Pubmed

A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

CACNA1A CACNA1B

9.02e-07414215728831
Pubmed

The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.

FXR2 FMR1

9.02e-07414216571602
Pubmed

G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

CACNA1A CACNA1B

9.02e-07414215953418
Pubmed

Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.

FXR2 FMR1

9.02e-07414218664458
Pubmed

The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.

CACNA1A CACNA1B

9.02e-07414225483588
Pubmed

A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.

FXR2 FMR1

9.02e-07414210556305
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B

1.50e-0651428825650
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B

1.50e-06514211296258
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1A CACNA1B

1.50e-06514216787652
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B

1.50e-06514215451373
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B

2.25e-06614235324301
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1A CACNA1B

2.25e-0661429238069
Pubmed

A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.

FXR2 FMR1

2.25e-06614211438699
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

CACNA1A CACNA1B

2.25e-06614212827191
Pubmed

beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.

CACNA1A CACNA1B

2.25e-06614210328888
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1A CACNA1B

3.16e-06714235176221
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B

5.41e-06914216382099
Pubmed

Screening for premutation in the FMR1 gene in male patients suspected of spinocerebellar ataxia.

CACNA1A FMR1

6.76e-061014219235102
Pubmed

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.

FXR2 FMR1

8.26e-061114229142209
Pubmed

Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.

FXR2 FMR1

8.26e-061114222022532
Pubmed

FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124.

FXR2 FMR1

8.26e-061114221957233
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1A CACNA1B

1.37e-051414221228161
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1B

1.58e-051514220188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1B

1.58e-051514224453333
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

R3HDM4 FXR2 PPP1R35 FMR1

2.77e-0546214431138677
Pubmed

The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation.

FXR2 FMR1

3.15e-052114237059803
Pubmed

The Repeat Expansion Diseases: The dark side of DNA repair.

CACNA1A FMR1

3.79e-052314226002199
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

CACNA1A CACNA1B

4.13e-052414222534482
Pubmed

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

FXR2 FMR1

5.25e-052714229420262
Pubmed

Full function of exon junction complex factor, Rbm8a, is critical for interneuron development.

FXR2 FMR1

5.65e-052814233154347
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNA1A CACNA1B

9.94e-053714225798587
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1A CACNA1B

1.05e-043814230786075
Pubmed

High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays.

FXR2 FMR1

1.82e-045014229560723
Pubmed

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

FXR2 FMR1

2.37e-045714217932509
Pubmed

CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.

FXR2 FMR1

3.78e-047214236123327
InteractionCACNB2 interactions

CACNA1A CACNA1B FMR1

4.69e-0723143int:CACNB2
InteractionCACNB1 interactions

CACNA1A CACNA1B FMR1

6.08e-0725143int:CACNB1
InteractionCACNB4 interactions

CACNA1A CACNA1B FMR1

6.08e-0725143int:CACNB4
InteractionPPP1R12C interactions

CACNA1A FXR2 FMR1

8.05e-0658143int:PPP1R12C
InteractionMIA3 interactions

CACNA1A FXR2 FLT4 FMR1

1.54e-05231144int:MIA3
InteractionNALCN interactions

CACNA1A CACNA1B

4.06e-0514142int:NALCN
InteractionSCN11A interactions

CACNA1A CACNA1B

4.68e-0515142int:SCN11A
InteractionSCN9A interactions

CACNA1A CACNA1B

9.34e-0521142int:SCN9A
InteractionCACNA1D interactions

CACNA1A CACNA1B

1.23e-0424142int:CACNA1D
InteractionDGKD interactions

FXR2 FMR1

1.33e-0425142int:DGKD
InteractionSCN1A interactions

CACNA1A CACNA1B

1.80e-0429142int:SCN1A
InteractionCACNB3 interactions

CACNA1A CACNA1B

2.20e-0432142int:CACNB3
InteractionCACNA1B interactions

CACNA1A CACNA1B

2.94e-0437142int:CACNA1B
InteractionCECR2 interactions

FXR2 FMR1

4.56e-0446142int:CECR2
InteractionEDC4 interactions

FXR2 PPP1R35 FMR1

4.62e-04226143int:EDC4
InteractionSCN5A interactions

CACNA1A CACNA1B

4.76e-0447142int:SCN5A
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B

8.89e-0526102253
GeneFamilyEF-hand domain containing

CACNA1B RASGRP4 PKD2

1.98e-04219103863
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

CACNA1A CACNA1B FLT4

2.04e-051751434db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

CACNA1A CACNA1B FLT4

2.04e-051751438d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC|Multiple_Sclerosis / Disease, condition lineage and cell class

CACNA1A CCDC61 POLR3D

3.04e-05200143ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
DrugIAA-94

CACNA1A CACNA1B FLT4 PKD2

4.57e-0861144CID000003667
DrugIHC-64

CACNA1A CACNA1B PKD2

9.99e-0733143CID000162753
DrugCNS 1145

CACNA1A CACNA1B PKD2

9.99e-0733143CID000190902
DrugAC 110

CACNA1A CACNA1B

2.11e-064142CID000022860
DrugS 8510

CACNA1A CACNA1B

3.51e-065142CID005488383
DrugCinildipine

CACNA1A CACNA1B PKD2

5.03e-0656143CID000002752
Drugalpha-sialylcholesterol

CACNA1A CACNA1B

5.26e-066142CID000133976
Drug3,4-dihydroquinazoline

CACNA1A CACNA1B

5.26e-066142CID000583065
Druggadolinium

CACNA1A CACNA1B FLT4 PKD2

5.29e-06199144CID000023982
Drugnilvadipine

CACNA1A CACNA1B PKD2

6.20e-0660143CID000004494
Druglercanidipine

CACNA1A CACNA1B PKD2

7.19e-0663143CID000065866
DrugAPMPA

CACNA1A CACNA1B

7.36e-067142CID000512300
Drugmibefradil

CACNA1A CACNA1B PKD2

7.54e-0664143CID000060662
Druggallopamil

CACNA1A CACNA1B PKD2

8.66e-0667143CID000001234
DrugAC1L2AC7

CACNA1A CACNA1B PKD2

9.47e-0669143CID000068733
DrugCAS 298-57-7

CACNA1A CACNA1B PKD2

1.12e-0573143CID000002761
Drugethosuximide

CACNA1A CACNA1B PKD2

1.17e-0574143CID000003291
Drugnisoldipine

CACNA1A CACNA1B PKD2

1.37e-0578143CID000004499
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1A CACNA1B PKD2

1.42e-0579143CID005287890
Drug4-aminopiperidine

CACNA1A CACNA1B

1.92e-0511142CID000424361
Drugleys

CACNA1A CACNA1B

1.92e-0511142CID000484683
DrugAC1NUZ8M

CACNA1A CACNA1B PKD2

2.25e-0592143CID000073211
DrugAC1L2VU3

CACNA1A CACNA1B

2.31e-0512142CID000129572
Drugmanidipine

CACNA1A CACNA1B PKD2

2.48e-0595143CID000004008
Drugisotetrandrine

CACNA1A CACNA1B PKD2

2.64e-0597143CID000005422
Drugnitrendipine

CACNA1A CACNA1B PKD2

2.72e-0598143CID000004507
Drugisradipine

CACNA1A CACNA1B PKD2

2.89e-05100143CID000003784
DrugAC1L1JG6

CACNA1A CACNA1B

3.18e-0514142CID000005026
Drugloperamide

CACNA1A CACNA1B PKD2

3.34e-05105143CID000003954
Drugbutamben

CACNA1A CACNA1B

3.67e-0515142CID000002482
Drugpentasulfane

CACNA1A CACNA1B

4.19e-0516142CID000448216
DrugVerapamil

CACNA1A CACNA1B

4.19e-0516142DB00661
Druglamotrigine

CACNA1A CACNA1B PKD2

4.50e-05116143CID000003878
DrugAC1NBU2S

CACNA1A CACNA1B PKD2

4.62e-05117143CID004473765
DrugPotassium Chloride

CACNA1A CACNA1B FMR1

4.62e-05117143ctd:D011189
Drug4-aminohexanoic Acid

FXR2 FMR1

5.34e-0518142CID000138490
Drugbepridil

CACNA1A CACNA1B PKD2

5.76e-05126143CID000002351
Drugpimozide

CACNA1A CACNA1B PKD2

5.90e-05127143CID000016362
Drugpranidipine

CACNA1A CACNA1B

5.97e-0519142CID006436048
DrugN6-Me-dAdo

CACNA1A CACNA1B

5.97e-0519142CID000168948
DrugLinuron

CACNA1A CACNA1B FMR1

6.04e-05128143ctd:D008044
Druglanthanum

CACNA1A CACNA1B PKD2

7.23e-05136143CID000023926
Drugcobalt-60

CACNA1A CACNA1B FLT4 PKD2

7.41e-05390144CID000061492
Drugisovalerate

CACNA1A CACNA1B PKD2

8.39e-05143143CID000010430
DrugDantrolene-13C3

CACNA1A CACNA1B PKD2

8.75e-05145143CID000002951
Drugnimodipine

CACNA1A CACNA1B PKD2

8.75e-05145143CID000004497
Drugnicardipine

CACNA1A CACNA1B PKD2

8.75e-05145143CID000004473
DrugLY320135

CACNA1A CACNA1B

8.82e-0523142CID005311257
Drugalpha-conotoxin SI

CACNA1A CACNA1B

8.82e-0523142CID000163979
Drugbarium

CACNA1A CACNA1B FLT4

9.30e-05148143CID000104810
DrugBay K 8644

CACNA1A CACNA1B PKD2

9.67e-05150143CID000002303
Druglead compounds

CACNA1A FXR2 FMR1

9.67e-05150143CID000073212
Drugprocaine

CACNA1A CACNA1B PKD2

1.03e-04153143CID000004914
Drugprocymidone

CACNA1A CACNA1B FMR1

1.07e-04155143ctd:C035988
Drugmelatonin

CACNA1A CACNA1B FXR2 FMR1

1.21e-04443144CID000000896
DrugmAHP

CACNA1A CACNA1B

1.22e-0427142CID000220531
Drugeniluracil

CACNA1A CACNA1B

1.22e-0427142CID000043157
Drugfelodipine

CACNA1A CACNA1B PKD2

1.38e-04169143CID000003333
Druggabapentin

CACNA1A CACNA1B PKD2

1.38e-04169143CID000003446
Druglavendustin A

CACNA1A CACNA1B PKD2

1.43e-04171143CID000003894
Drugriluzole

CACNA1A CACNA1B PKD2

1.50e-04174143CID000005070
DrugAC1NDLJ6

FXR2 FMR1

1.51e-0430142CID004627775
Drugpapaverine

CACNA1A CACNA1B PKD2

1.55e-04176143CID000004680
DrugNSC7524

CACNA1A CACNA1B PKD2

1.71e-04182143CID000005657
Drug3-aminopropylphosphinic acid

CACNA1A CACNA1B

1.72e-0432142CID006335948
DrugA61603

CACNA1A CACNA1B

1.83e-0433142CID004038180
Drugfluspirilene

CACNA1A CACNA1B

1.95e-0434142CID000003396
DrugAliquat 336

CACNA1A CACNA1B

1.95e-0434142CID000021218
DrugNSC759576

CACNA1A CACNA1B PKD2

1.98e-04191143CID000003075
Drugbaclofen

CACNA1A CACNA1B PKD2

1.98e-04191143CID000002284
Drugdihydropyridine

CACNA1A CACNA1B PKD2

2.04e-04193143CID000104822
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A

CACNA1A FXR2 FLT4

2.04e-041931433262_UP
Drug3-7a

CACNA1A CACNA1B

2.19e-0436142CID011987860
DrugCP-80

CACNA1A CACNA1B

2.19e-0436142CID000452640
DrugGinkgolide A [15291-75-5]; Down 200; 9.8uM; MCF7; HT_HG-U133A

MRPS30 R3HDM4 FXR2

2.20e-041981433260_DN
DrugELAN

CACNA1A CACNA1B

2.31e-0437142CID000009469
Drug1-EBIO

CACNA1A CACNA1B

2.31e-0437142CID000082320
Drug8-cyclopentyltheophylline

CACNA1A CACNA1B

2.44e-0438142CID000001917
Drug3,4-diaminopyridine

CACNA1A CACNA1B

2.44e-0438142CID000005918
DrugE 14

CACNA1A CACNA1B

2.57e-0439142CID000122591
DrugBMY 7378

CACNA1A CACNA1B

2.84e-0441142CID000002419
DrugAC1L1I54

CACNA1A CACNA1B

2.84e-0441142CID000004426
Drugphenytoin

CACNA1A CACNA1B PKD2

2.95e-04219143CID000001775
DrugFk 888

CACNA1A CACNA1B

2.98e-0442142CID000107967
DrugK-Cl

CACNA1A CACNA1B FLT4 FMR1

3.12e-04567144CID000004873
DrugAC1L1KGC

FXR2 FLT4 FMR1

3.20e-04225143CID000005486
Drug5'-CG-3

CACNA1A FMR1

3.27e-0444142CID000482125
Drugh PM

CACNA1A CACNA1B

3.42e-0445142CID005494424
Drug3-(1H-pyrrole-2-carboxylate

CACNA1A CACNA1B PKD2

3.54e-04233143CID000005114
DrugKW-3049

CACNA1A CACNA1B

4.23e-0450142CID000002324
Drugnefiracetam

CACNA1A CACNA1B

5.31e-0456142CID000071157
Drugprochloraz

CACNA1A CACNA1B FMR1

5.33e-04268143ctd:C045362
Drugnalidixic acid

FXR2 FLT4 FMR1

5.87e-04277143CID000004421
Drugetorphine

CACNA1A CACNA1B

5.89e-0459142CID000026721
Druggabapentin

CACNA1A CACNA1B

5.89e-0459142ctd:C040029
Diseasemalignant pleural mesothelioma (implicated_via_orthology)

FXR2 FMR1

3.79e-073112DOID:7474 (implicated_via_orthology)
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B

3.79e-073112DOID:0111181 (implicated_via_orthology)
Diseasefragile X syndrome (implicated_via_orthology)

FXR2 FMR1

3.79e-073112DOID:14261 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B

7.58e-074112DOID:6364 (implicated_via_orthology)
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B

2.65e-067112DOID:0050951 (implicated_via_orthology)
Diseaseage at first birth measurement

MRPS30 CACNA1A

8.81e-04120112EFO_0009101
Diseaseautism spectrum disorder (implicated_via_orthology)

FXR2 FMR1

1.41e-03152112DOID:0060041 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

CACNA1A CACNA1B

1.61e-03163112DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
RARHREGSRPARGGE

CACNA1A

976

O00555
RQERGLGHRVAGRRG

CCDC61

231

Q9Y6R9
KGERRARHRGGPRAG

CACNA1B

951

Q00975
RRRGPGRGEDRRRED

R3HDM4

146

Q96D70
RGEESRRRPTGGRGR

FXR2

476

P51116
GKIGGRGRPRQVRRH

RASGRP4

16

Q8TDF6
RGSRPYRNRGHGRRG

FMR1

471

Q06787
VRGEEIIPRGHRRGR

MRPS30

211

Q9NP92
RDRQREGHGRGRGRP

POLR3D

86

P05423
RRGRGQHRRGGVARA

PNMA3

386

Q9UL41
RHGSPGRRKGRAERR

PPP1R35

56

Q8TAP8
EGRGRGRDPHRDRTR

NSMCE4A

11

Q9NXX6
QGRRRRPERGARGGQ

FLT4

1316

P35916
GAGHPSGRRRRREDQ

PKD2

146

Q13563
RSRARRGHLGNGDRP

nan

61

Q8N1X5