Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentexternal encapsulating structure

FGA PKHD1L1 LAMB3 ACHE LAMB4 ACAN NCAN

4.68e-06658237GO:0030312
GeneOntologyCellularComponentbasement membrane

LAMB3 ACHE LAMB4 ACAN

8.97e-06122234GO:0005604
GeneOntologyCellularComponentcollagen-containing extracellular matrix

FGA LAMB3 ACHE LAMB4 ACAN NCAN

1.81e-05530236GO:0062023
GeneOntologyCellularComponentperineuronal net

ACAN NCAN

5.18e-0510232GO:0072534
GeneOntologyCellularComponentextracellular matrix

FGA LAMB3 ACHE LAMB4 ACAN NCAN

5.97e-05656236GO:0031012
GeneOntologyCellularComponentperisynaptic extracellular matrix

ACAN NCAN

6.33e-0511232GO:0098966
GeneOntologyCellularComponentsynapse-associated extracellular matrix

ACAN NCAN

8.97e-0513232GO:0099535
GeneOntologyCellularComponentpericentriolar material

TNKS PCM1

4.30e-0428232GO:0000242
GeneOntologyCellularComponentlysosomal lumen

ACAN NCAN

5.16e-0398232GO:0043202
MousePhenointervertebral disk degeneration

KY ACAN

2.91e-056202MP:0004684
MousePhenoincreased granulocyte number

SBF1 PKHD1L1 ACHE ACAN WAS SEC63

1.37e-04597206MP:0000322
MousePhenoincreased neutrophil cell number

SBF1 PKHD1L1 ACHE WAS SEC63

1.38e-04368205MP:0000219
DomainWASPfam_EVH1

WASL WAS

1.32e-062222IPR033927
DomainWASP_C

WASL WAS

2.77e-057222IPR011026
DomainWH1

WASL WAS

7.24e-0511222SM00461
DomainWH1/EVH1_dom

WASL WAS

7.24e-0511222IPR000697
DomainWH1

WASL WAS

7.24e-0511222PF00568
Domain-

WASL WAS

8.68e-05122223.90.810.10
DomainWH1

WASL WAS

1.03e-0413222PS50229
DomainWH2

WASL WAS

1.20e-0414222SM00246
DomainLAMININ_NTER

LAMB3 LAMB4

1.57e-0416222PS51117
DomainLaminin_N

LAMB3 LAMB4

1.57e-0416222PF00055
DomainWH2

WASL WAS

1.57e-0416222PF02205
DomainPBD

WASL WAS

1.57e-0416222SM00285
DomainLaminin_N

LAMB3 LAMB4

1.57e-0416222IPR008211
DomainLamNT

LAMB3 LAMB4

1.57e-0416222SM00136
DomainPBD

WASL WAS

1.78e-0417222PF00786
DomainEGF_1

NRXN2 LAMB3 LAMB4 NCAN

2.05e-04255224PS00022
DomainEGF-like_CS

NRXN2 LAMB3 LAMB4 NCAN

2.24e-04261224IPR013032
DomainEGF_2

NRXN2 LAMB3 LAMB4 NCAN

2.37e-04265224PS01186
DomainCRIB

WASL WAS

2.48e-0420222PS50108
DomainWH2_dom

WASL WAS

2.74e-0421222IPR003124
DomainCRIB_dom

WASL WAS

2.74e-0421222IPR000095
DomainWH2

WASL WAS

3.60e-0424222PS51082
DomainEGF_LAM_2

LAMB3 LAMB4

5.65e-0430222PS50027
DomainEGF_LAM_1

LAMB3 LAMB4

5.65e-0430222PS01248
DomainLaminin_EGF

LAMB3 LAMB4

7.70e-0435222PF00053
DomainEGF_Lam

LAMB3 LAMB4

7.70e-0435222SM00180
DomainLaminin_EGF

LAMB3 LAMB4

9.08e-0438222IPR002049
DomainIg_E-set

PKHD1L1 SEC63

6.60e-03104222IPR014756
DomainEGF

NRXN2 NCAN

9.55e-03126222PF00008
Domain-

SBF1 WASL WAS

1.04e-023912232.30.29.30
DomainPH_dom-like

SBF1 WASL WAS

1.31e-02426223IPR011993
Pubmed

N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.

WASL WAS

4.56e-07224211584271
Pubmed

Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.

WASL WAS

4.56e-07224220071778
Pubmed

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters.

WASL WAS

4.56e-07224238085658
Pubmed

N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis.

WASL WAS

4.56e-07224220599953
Pubmed

Wiskott-Aldrich syndrome: a comprehensive review.

WASL WAS

4.56e-07224223527602
Pubmed

Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamics.

WASL WAS

4.56e-07224231916311
Pubmed

X-ray scattering study of activated Arp2/3 complex with bound actin-WCA.

WASL WAS

4.56e-07224218462674
Pubmed

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

WASL WAS

4.56e-07224217878299
Pubmed

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).

WASL WAS

4.56e-07224218650809
Pubmed

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function.

WASL WAS

1.37e-06324222411869
Pubmed

Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.

WASL WAS

1.37e-06324226463123
Pubmed

N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts.

WASL WAS

1.37e-06324217182853
Pubmed

Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.

WASL WAS

1.37e-06324220150425
Pubmed

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.

WASL WAS

1.37e-06324210724160
Pubmed

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.

WASL WAS

1.37e-06324211340081
Pubmed

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP.

WASL WAS

1.37e-0632429422512
Pubmed

Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.

WASL WAS

1.37e-06324219741094
Pubmed

The spatiotemporal expression pattern of Syndecans in murine embryonic teeth.

SPOCK1 ACAN NCAN

1.70e-063424332220631
Pubmed

Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

WASL WAS

2.74e-06424222921828
Pubmed

Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.

WASL WAS

2.74e-06424222585739
Pubmed

Lecticans: organizers of the brain extracellular matrix.

ACAN NCAN

2.74e-06424210766023
Pubmed

N-wasp is essential for the negative regulation of B cell receptor signaling.

WASL WAS

4.56e-06524224223520
Pubmed

A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.

WASL WAS

4.56e-06524212872157
Pubmed

Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.

WASL WAS

4.56e-06524215169891
Pubmed

Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization.

WASL WAS

4.56e-06524210563804
Pubmed

Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.

WASL WAS

4.56e-06524216293614
Pubmed

The acidic regions of WASp and N-WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia.

WASL WAS

4.56e-06524211943145
Pubmed

Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology.

WASL WAS

4.56e-06524227143109
Pubmed

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.

WASL WAS

4.56e-06524211052943
Pubmed

Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.

NRXN2 ACHE

4.56e-0652429223334
Pubmed

FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro.

WASL WAS

4.56e-06524223437151
Pubmed

An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.

WASL WAS

6.83e-06624216246732
Pubmed

Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.

WASL WAS

6.83e-06624216582881
Pubmed

De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation.

WASL WAS

6.83e-06624236622335
Pubmed

Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.

WASL WAS

9.56e-06724216418535
Pubmed

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer.

WASL WAS

9.56e-06724226506240
Pubmed

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.

ACAN NCAN

9.56e-06724221976490
Pubmed

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.

WASL WAS

1.27e-05824210381382
Pubmed

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex.

WASL WAS

1.27e-05824211146629
Pubmed

Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons.

WASL WAS

1.64e-05924218539136
Pubmed

TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2.

STK3 PCM1

3.00e-051224237354905
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

WASL WAS

3.54e-051324216723544
Pubmed

Muscleblind-like 1 is required for normal heart valve development in vivo.

ACAN NCAN

4.77e-051524226472242
Pubmed

Confirmation and dissection of QTL controlling resistance to malaria in mice.

ACHE NCAN

6.17e-051724215170228
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

LAMB3 LAMB4

6.94e-051824211311202
Pubmed

Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.

SPOCK1 ACAN

6.94e-051824212684764
Pubmed

Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity.

SPOCK1 ACAN

9.51e-052124234011608
Pubmed

Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes.

ACAN NCAN

1.25e-042424225344368
Pubmed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

FGA LAMB3 WASL CLINT1 SEC63

1.32e-0474224526871637
Pubmed

Analysis of the Tropism of SARS-CoV-2 Based on the Host Interactome of the Spike Protein.

LAMB3 SEC63

2.10e-043124237939376
Pubmed

Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.

ACAN CHAC1

3.33e-043924221606205
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SBF1 NRXN2 FGA WASL PCM1 NCAN

3.41e-04143124637142655
Pubmed

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

TMEM94 CLINT1

3.68e-04412428724849
Pubmed

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.

SPOCK1 LAMB3 NCAN

4.00e-0421024316537572
Pubmed

The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.

PCM1 CLINT1

4.64e-044624234265304
Pubmed

Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.

STK3 WASL

4.64e-044624223555292
Pubmed

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

ETAA1 PCM1 SEC63

4.77e-0422324334226595
Pubmed

CIN85 interacting proteins in B cells-specific role for SHIP-1.

WASL WAS

6.39e-045424221725061
Pubmed

Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.

MKRN4P ACAN

6.63e-045524229997285
InteractionWIPF2 interactions

FGA WASL WAS

1.77e-0543243int:WIPF2
CytobandEnsembl 112 genes in cytogenetic band chr7q31

LAMB4 WASL

2.44e-03140242chr7q31
CytobandEnsembl 112 genes in cytogenetic band chrXp11

MKRN4P WAS

1.65e-02377242chrXp11
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ACAN NCAN

3.34e-064142574
GeneFamilyLaminin subunits

LAMB3 LAMB4

3.66e-0512142626
GeneFamilyWiskott-Aldrich Syndrome protein family

WASL WAS

6.64e-051614214
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ACAN NCAN

4.49e-04411421298
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ACAN NCAN

8.67e-04571421179
GeneFamilyAdenosine receptors|V-set domain containing

ACAN NCAN

6.85e-03163142590
GeneFamilyEndogenous ligands

FGA NCAN

1.40e-02237142542
CoexpressionNABA_CORE_MATRISOME

FGA SPOCK1 LAMB3 LAMB4 ACAN NCAN

1.10e-07275236M5884
CoexpressionNABA_CORE_MATRISOME

FGA SPOCK1 LAMB3 ACAN NCAN

3.23e-06270235MM17057
CoexpressionNABA_PROTEOGLYCANS

SPOCK1 ACAN NCAN

3.79e-0635233M5882
CoexpressionNABA_PROTEOGLYCANS

SPOCK1 ACAN NCAN

4.13e-0636233MM17061
CoexpressionNABA_MATRISOME

FGA SPOCK1 KY LAMB3 LAMB4 ACAN NCAN

1.95e-051026237M5889
CoexpressionGSE41867_DAY8_VS_DAY15_LCMV_CLONE13_EFFECTOR_CD8_TCELL_UP

WASL TNKS PCM1 CLINT1

2.60e-05200234M9449
CoexpressionBONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING

SBF1 SPOCK1 TNKS WAS SEC63

6.63e-05506235M253
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

NRXN2 SPOCK1 KY ACHE ACAN

1.38e-04591235M2019
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

NRXN2 SPOCK1 KY ACHE ACAN

1.49e-04601235MM866
CoexpressionNABA_MATRISOME

FGA SPOCK1 KY LAMB3 ACAN NCAN

1.83e-041008236MM17056
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPOCK1 LAMB3 ACHE CHAC1

7.17e-071382342e46d546ad962aa0fde5b1c18c2a5370a4424e9f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPOCK1 LAMB3 ACHE CHAC1

8.50e-07144234163c591fedad2beb7f92531e6240e9554f90ea40
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 ACHE ACAN NCAN

2.07e-06180234fa819df81fca95c2cc602fede635cb03e3f35fad
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 ACHE ACAN NCAN

2.07e-06180234907cd510fd2e21532ce04ba687e8894f7af71f27
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NRXN2 SPOCK1 ACHE ACAN

2.90e-06196234671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NRXN2 SPOCK1 ACHE ACAN

2.90e-06196234f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|368C / Donor, Lineage, Cell class and subclass (all cells)

NLRC5 CHAC1 WAS

5.77e-051472333ed5b020ce1f1277917d79ef1f7da53fa474e8db
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

NLRC5 LAMB4 ACAN

6.88e-05156233afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellIIF-Lymphocyte-B-Plasmablast|IIF / Disease, Lineage and Cell Type

PKHD1L1 KY CHAC1

7.56e-051612334d78985e7b11e92591e75a4864fd769882db2d1c
ToppCell15-Airway-Immune-Hematopoietic,_B_Cells|Airway / Age, Tissue, Lineage and Cell class

NLRC5 CHAC1 WAS

9.19e-0517223336f2444754f1e37683cb812380e6b05b356f9f4a
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SPOCK1 ACHE

1.05e-041802330677bf4a5177d9cbc6716195bd966eeae8de2f31
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 ACAN NCAN

1.12e-041842338d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 ACAN NCAN

1.12e-04184233278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCM1 CLINT1 WAS

1.14e-041852337adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SPOCK1 ACHE

1.16e-041862332f103ce2427f9cf2c1fafb6bd6045c5863a47549
ToppCelldroplet-Lung-LUNG-1m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 PKHD1L1 ACHE

1.18e-041872339c9ae8725905ba0cfe407878006ed06c2480fb72
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 PKHD1L1 ACHE

1.18e-041872339e9460e57cdc9cd0a0de2866b140e06d0bc19a8f
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRXN2 PKHD1L1 ACHE

1.20e-04188233dc52dd2957be3f40001f0a56f3d9ac9d66ea466e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KY ACHE NCAN

1.20e-04188233a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRXN2 PKHD1L1 ACHE

1.20e-041882332ef08313087e91985bcffc46c3798470cdeec49c
ToppCelldroplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRXN2 PKHD1L1 ACHE

1.20e-041882331f1604b6dc0a8ad0be3d9aac0bef448459c22465
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACHE ACAN NCAN

1.20e-04188233053c251d3ddbeb866f34565aefca4535517b4387
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACHE ACAN NCAN

1.20e-041882337471c194276161422326647f09022e94f3d1640c
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KY ACHE NCAN

1.20e-04188233c8530c9ff98666c64a94683261af4288cb790a7e
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SPOCK1 ACHE

1.21e-04189233fcc3713e8200d51074f709f3360fb36efb0a639f
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NRXN2 SPOCK1 ACAN

1.23e-041902336c7e1086c0a274cd5527c3104106e372811c9905
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SPOCK1 ACHE

1.23e-04190233e792e42fc49472eaf974eb0905819eb51a1da8e5
ToppCell18-Airway-Immune-Immune|Airway / Age, Tissue, Lineage and Cell class

NLRC5 ACAN WAS

1.23e-0419023309e6bbe4f1be48153dc6cd647a57a0b531b8bf99
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SPOCK1 ACHE

1.27e-04192233550a6574a93acadb43c449094565c73ca51a0c5c
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SPOCK1 ACHE

1.29e-041932336995ee29bf403a71247de92a37dfd851be5acf2e
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SPOCK1 ACHE

1.29e-041932337fcfb0f76789fa8d8caa18304cb43c8fd899a81b
ToppCellmLN-(5)_Dendritic_cell-(53)_Lymphoid_DC|mLN / shred on region, Cell_type, and subtype

NRXN2 LAMB3 ACHE

1.39e-04198233da84c76afe835aeee39da04b63c03549218b5d91
ToppCellmLN-Dendritic_cell-Lymphoid_DC|mLN / Region, Cell class and subclass

NRXN2 LAMB3 ACHE

1.39e-041982333965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NRXN2 SPOCK1 ACHE

1.39e-0419823302d0d8a212e09c0962ab1dae6a885d26d357f66a
ToppCell(02)_MMP9/10+|World / shred by cell type by condition

SPOCK1 LAMB3 CHAC1

1.41e-041992333f78eddeaa67d3b767aa38de765632166b09a4f0
ToppCellmetastatic_Brain|World / Location, Cell class and cell subclass

FGA LAMB3 ACHE

1.41e-04199233a6793145de96bcdbfd4fe04159e34ea2244ca5a8
Drug5155877; Up 200; 10uM; MCF7; HT_HG-U133A

ETAA1 TNKS CLINT1 CHAC1

3.83e-051922346574_UP
DrugTriflusal [322-79-2]; Down 200; 16.2uM; MCF7; HT_HG-U133A

ETAA1 STK3 LAMB3 CHAC1

4.07e-051952342867_DN
DrugEtofenamate [30544-47-9]; Down 200; 10.8uM; MCF7; HT_HG-U133A

ETAA1 LAMB3 TMEM94 CHAC1

4.07e-051952347327_DN
DrugNitrocaramiphen hydrochloride; Up 200; 10.8uM; MCF7; HT_HG-U133A

SBF1 FGA SPOCK1 LAMB4

4.15e-051962346504_UP
DrugCefmetazole sodium salt [56796-39-5]; Down 200; 8.2uM; MCF7; HT_HG-U133A

SBF1 TMEM94 TNKS WAS

4.15e-051962347222_DN
DrugYohimbinic acid monohydrate [27801-27-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A

LAMB3 ACAN WASL WAS

4.23e-051972342803_UP
DrugLincomycin hydrochloride [859-18-7]; Up 200; 9uM; MCF7; HT_HG-U133A

ETAA1 SBF1 LAMB3 PCM1

4.23e-051972347411_UP
DrugIopromide [73334-07-3]; Down 200; 5uM; PC3; HT_HG-U133A

ACAN WASL PCM1 WAS

4.23e-051972344504_DN
DrugGuanabenz acetate [23256-50-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

ETAA1 STK3 PCM1 WAS

4.32e-051982341544_DN
DrugTrimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; MCF7; HT_HG-U133A

SBF1 TMEM94 TNKS PCM1

4.32e-051982347235_DN
DrugFluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; PC3; HT_HG-U133A

STK3 LAMB4 ACAN CHAC1

4.32e-051982343995_UP
DrugPepstatin A [26305-03-3]; Down 200; 5.8uM; MCF7; HT_HG-U133A

SBF1 PCM1 CHAC1 WAS

4.32e-051982343264_DN
Drug2,6-dimethoxyphenol

SPOCK1 WASL WAS

4.32e-0568233CID000007041
DrugSC-560; Up 200; 10uM; MCF7; HT_HG-U133A

ETAA1 PCM1 CHAC1 WAS

4.40e-051992346870_UP
Drugo-nitrophenyl beta-D-fucopyranoside

WASL CLINT1 WAS

5.57e-0574233CID000004597
Drug2evc

ACHE ACAN

7.56e-0513232CID000647499
Drughyaluronan

FGA SPOCK1 ACAN NCAN

1.30e-04263234CID000024759
Drugfonofos

ACHE CLINT1

1.32e-0417232CID000013676
DrugEinecs 304-521-7

WASL WAS

1.48e-0418232CID011979814
DrugSulfamethoxazole

ACHE ACAN

1.48e-0418232ctd:D013420
Drugfluoride

NRXN2 ACHE WASL WAS

1.60e-04278234CID000014917
Drugmalachite green

FGA ACAN

2.23e-0422232CID000011294
DrugAC1Q6CTU

FGA ACHE WAS

2.23e-04118233CID000021362
DrugAC1L3OPK

ACHE CLINT1

2.66e-0424232CID000119381
DrugAPPT

FGA ACAN

2.89e-0425232CID000124311
Drug1 EC 1

ACAN WAS

3.13e-0426232CID000445307
DrugGlucose

FGA LAMB3 ACHE CLINT1 CHAC1 WAS SEC63

3.65e-041420237ctd:D005947
DrugLMWH

FGA SPOCK1 ACHE LAMB4 ACAN

4.49e-04663235CID000000772
DrugSpiperone [749-02-0]; Up 200; 10.2uM; PC3; HT_HG-U133A

LAMB3 ACAN CHAC1

5.64e-041622335777_UP
Drughexaethylene glycol

CLINT1 WAS

5.69e-0435232CID000017472
Drugmaltos

FGA LAMB4 ACAN WAS

5.97e-04393234CID000000294
Drugwiskostatin

WASL WAS

7.07e-0439232CID000448668
DrugE 14

ACAN NCAN

7.07e-0439232CID000122591
Drug3 SA

WASL WAS

7.81e-0441232CID000449164
DrugAC1L1IMA

KY CLINT1

7.81e-0441232CID000004639
Drug15d-PGJ2; Up 200; 10uM; MCF7; HT_HG-U133A

SBF1 CHAC1 WAS

7.91e-041822336990_UP
DrugPyrvinium pamoate [3546-41-6]; Up 200; 3.4uM; PC3; HT_HG-U133A

ACAN PCM1 CHAC1

8.04e-041832336339_UP
Drugtrisodium citrate dihydrate

FGA ACAN

8.20e-0442232CID000071474
DrugBenzethonium chloride [121-54-0]; Up 200; 9uM; MCF7; HT_HG-U133A

WASL PCM1 CHAC1

8.29e-041852337207_UP
DrugLY 294002; Down 200; 10uM; HL60; HT_HG-U133A

SBF1 LAMB3 CHAC1

8.42e-041862336198_DN
DrugNaringenine [480-41-1]; Down 200; 14.6uM; MCF7; HT_HG-U133A

TNKS PCM1 WAS

8.55e-041872333278_DN
DrugGBR 12909 dihydrochloride [67469-78-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A

LAMB4 CHAC1 WAS

8.55e-041872333240_UP
DrugAC1NDLZU

KY NCAN

8.60e-0443232CID004627981
DrugGossypol [303-45-7]; Up 200; 7.8uM; PC3; HT_HG-U133A

ACAN PCM1 CHAC1

8.69e-041882334296_UP
Drug0297417-0002B [362658-29-5]; Up 200; 10uM; PC3; HT_HG-U133A

LAMB4 CHAC1 WAS

8.82e-041892336895_UP
DrugMinocycline hydrochloride [13614-98-7]; Up 200; 8uM; HL60; HT_HG-U133A

SPOCK1 TNKS CHAC1

8.82e-041892332405_UP
DrugDeltaline [6836-11-9]; Down 200; 7.8uM; PC3; HT_HG-U133A

WASL PCM1 CHAC1

8.96e-041902334306_DN
DrugDoxycycline hydrochloride [10592-13-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A

TMEM94 ACAN WAS

9.09e-041912337195_UP
DrugTracazolate hydrochloride [41094-88-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A

SBF1 CHAC1 WAS

9.09e-041912337339_UP
DrugChlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; MCF7; HT_HG-U133A

SPOCK1 ACAN CHAC1

9.09e-041912332627_UP
DrugHomatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; PC3; HT_HG-U133A

SBF1 WASL CHAC1

9.23e-041922335058_DN
DrugMeclozine dihydrochloride [1104-22-9]; Up 200; 8.6uM; MCF7; HT_HG-U133A

SPOCK1 LAMB4 CHAC1

9.23e-041922335607_UP
DrugCyanocobalamin [68-19-9]; Down 200; 3uM; MCF7; HT_HG-U133A

SBF1 PCM1 WAS

9.23e-041922333252_DN
DrugSyrosingopine [84-36-6]; Up 200; 6uM; MCF7; HT_HG-U133A

ETAA1 PCM1 CHAC1

9.23e-041922336213_UP
DrugIdoxuridine [54-42-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A

STK3 LAMB3 CHAC1

9.37e-041932331480_UP
DrugCarcinine [56897-53-1]; Down 200; 22uM; MCF7; HT_HG-U133A

SBF1 PCM1 WAS

9.37e-041932333242_DN
DrugProcaine hydrochloride [51-05-8]; Down 200; 14.6uM; MCF7; HT_HG-U133A

STK3 PCM1 WAS

9.37e-041932335430_DN
DrugTranylcypromine hydrochloride [1986-47-6]; Down 200; 23.6uM; HL60; HG-U133A

ACAN CHAC1 WAS

9.37e-041932331417_DN
DrugAC1OAGKW

SBF1 WASL CLINT1

9.37e-04193233CID006857413
Drug5211181; Up 200; 12uM; MCF7; HT_HG-U133A_EA

SBF1 LAMB3 WAS

9.37e-04193233950_UP
DrugBenzydamine hydrochloride [132-69-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A

STK3 CHAC1 WAS

9.51e-041942333169_DN
DrugPrednicarbate [73771-04-7]; Down 200; 8.2uM; MCF7; HT_HG-U133A

SBF1 STK3 CHAC1

9.51e-041942335544_DN
DrugMemantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A

ETAA1 TMEM94 PCM1

9.51e-041942337354_DN
DrugBenzocaine [94-09-7]; Up 200; 24.2uM; PC3; HT_HG-U133A

NRXN2 FGA STK3

9.51e-041942334224_UP
DrugScopolamine hydrochloride [55-16-3]; Down 200; 11.8uM; PC3; HT_HG-U133A

ETAA1 SBF1 PCM1

9.51e-041942334219_DN
DrugDirithromycin [62013-04-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A

SBF1 CHAC1 WAS

9.51e-041942332863_DN
DrugJosamycin [16846-24-5]; Up 200; 4.8uM; HL60; HG-U133A

ACAN PCM1 CHAC1

9.51e-041942332034_UP
DrugPF-00562151-00 [351320-12-2]; Up 200; 10uM; MCF7; HT_HG-U133A

SBF1 CHAC1 NCAN

9.51e-041942335954_UP
DrugZardaverine [101975-10-4]; Up 200; 15uM; MCF7; HT_HG-U133A

SBF1 ACAN WAS

9.51e-041942337347_UP
DrugPronethalol hydrochloride [51-02-5]; Down 200; 15uM; MCF7; HT_HG-U133A

ETAA1 LAMB3 PCM1

9.51e-041942337322_DN
DrugMinaprine dihydrochloride [25953-17-7]; Down 200; 10.8uM; HL60; HG-U133A

SBF1 TMEM94 ACAN

9.66e-041952331968_DN
DrugTestosterone propionate [57-85-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A

LAMB4 PCM1 CHAC1

9.66e-041952335636_UP
DrugChlorhexidine [55-56-1]; Up 200; 8uM; HL60; HG-U133A

ACAN CHAC1 WAS

9.66e-041952332025_UP
DrugEstropipate [7280-37-7]; Up 200; 9.2uM; MCF7; HT_HG-U133A

SBF1 ACAN CHAC1

9.66e-041952336808_UP
DrugPimethixene maleate [13187-06-9]; Up 200; 9.8uM; MCF7; HT_HG-U133A

ACAN CHAC1 WAS

9.66e-041952337468_UP
DrugMyosmine [532-12-7]; Up 200; 27.4uM; MCF7; HT_HG-U133A

SBF1 FGA WAS

9.66e-041952333634_UP
DrugDihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; MCF7; HT_HG-U133A

SBF1 LAMB3 CHAC1

9.66e-041952337034_UP
DrugOxprenolol hydrochloride [6452-73-9]; Down 200; 13.2uM; MCF7; HT_HG-U133A

SBF1 TMEM94 WAS

9.66e-041952337225_DN
DrugPrimaquine diphosphate [63-45-6]; Up 200; 8.8uM; PC3; HT_HG-U133A

NRXN2 FGA STK3

9.66e-041952334263_UP
Drug17-DMAG; Down 200; 0.1uM; HL60; HT_HG-U133A

SBF1 PCM1 WAS

9.66e-041952336172_DN
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A

LAMB4 ACAN CHAC1

9.66e-041952335582_UP
DrugTamoxifen citrate [54965-24-1]; Down 200; 7uM; HL60; HG-U133A

TMEM94 ACAN PCM1

9.66e-041952331366_DN
DrugAconitine [302-27-2]; Down 200; 6.2uM; MCF7; HT_HG-U133A

ETAA1 PCM1 CHAC1

9.66e-041952332776_DN
DrugAmodiaquin dihydrochloride dihydrate [6398-98-7]; Up 200; 8.6uM; MCF7; HT_HG-U133A

ETAA1 ACHE PCM1

9.66e-041952336224_UP
DrugCephapirin sodium salt [24356-60-3]; Down 200; 9uM; PC3; HT_HG-U133A

TMEM94 PCM1 CHAC1

9.80e-041962337142_DN
DrugGleevec; Up 200; 10uM; MCF7; HG-U133A

SBF1 ACAN CHAC1

9.80e-04196233366_UP
DrugApomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; PC3; HG-U133A

ETAA1 SBF1 CHAC1

9.80e-041962331923_UP
DrugAG-028671 [847803-03-6]; Down 200; 10uM; PC3; HT_HG-U133A

SBF1 PCM1 CLINT1

9.80e-041962336582_DN
DrugEnoxacin [74011-58-8]; Down 200; 12.4uM; HL60; HG-U133A

ACAN PCM1 CHAC1

9.80e-041962331597_DN
DrugTerconazole [67915-31-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A

ETAA1 STK3 WAS

9.80e-041962332844_DN
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

SBF1 CHAC1 WAS

9.80e-041962335563_DN
DrugChlortetracycline hydrochloride [64-72-2]; Up 200; 7.8uM; PC3; HG-U133A

SBF1 ACAN CHAC1

9.80e-041962331958_UP
DrugNialamide [51-12-7]; Up 200; 13.4uM; MCF7; HT_HG-U133A

LAMB4 WASL PCM1

9.80e-041962333871_UP
DrugOxprenolol hydrochloride [6452-73-9]; Up 200; 13.2uM; MCF7; HT_HG-U133A

SPOCK1 LAMB4 PCM1

9.80e-041962337225_UP
Drugchlorpropamide; Up 200; 100uM; MCF7; HG-U133A

STK3 WASL PCM1

9.80e-04196233144_UP
DrugAtractyloside potassium salt [102130-43-8]; Up 200; 5uM; MCF7; HT_HG-U133A

LAMB4 CHAC1 WAS

9.80e-041962333435_UP
DrugImipramine hydrochloride [113-52-0]; Down 200; 12.6uM; MCF7; HT_HG-U133A

SBF1 LAMB3 CHAC1

9.80e-041962331685_DN
DrugNifurtimox [23256-30-6]; Up 200; 14uM; MCF7; HT_HG-U133A

SBF1 ACAN PCM1

9.80e-041962337328_UP
DrugCalciferol [50-14-6]; Up 200; 10uM; HL60; HT_HG-U133A

ETAA1 ACAN NCAN

9.80e-041962332442_UP
DrugLorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A

SBF1 CHAC1 WAS

9.80e-041962335619_DN
DiseaseWiskott-Aldrich syndrome (implicated_via_orthology)

WASL WAS

3.48e-064232DOID:9169 (implicated_via_orthology)
Diseasecomplex trait

NLRC5 ACHE TNKS NCAN

5.37e-05271234EFO_0010578
Diseasesleep duration, high density lipoprotein cholesterol measurement

NLRC5 KY TMEM94

1.12e-04121233EFO_0004612, EFO_0005271
Diseasemultiple sclerosis (is_marker_for)

ACHE ACAN

6.68e-0449232DOID:2377 (is_marker_for)
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

NLRC5 TNKS NCAN

6.83e-04224233EFO_0004574, EFO_0008317
DiseaseDrug toxicity

FGA ACHE

1.95e-0384232C0013221
DiseaseAdverse reaction to drug

FGA ACHE

1.95e-0384232C0041755
Diseasecholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

TNKS NCAN

3.31e-03110232EFO_0008317, EFO_0008596, EFO_0010351
Diseasechylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement

TNKS NCAN

3.31e-03110232EFO_0004574, EFO_0008317, EFO_0008596

Protein segments in the cluster

PeptideGeneStartEntry
WANFARTGDPNEPRD

ACHE

511

P22303
NPGQQRNHFWEFFEE

MKRN4P

446

Q13434
DFGDWSAFNQAPSGP

CLINT1

371

Q14677
GFNGFNLQISDPWDP

ERVFC1-1

176

P60608
PMFPESFGNWGQDNE

KY

566

Q8NBH2
GPFEDGMNDQDLPNW

PCM1

6

Q15154
LDFAFFDNQPQAPWG

NLRC5

1851

Q86WI3
WRPNQPDNFFAAGED

ACAN

2401

P16112
PNDPDGQNDIFWDQN

ETAA1

96

Q9NY74
WEDNPFPQGIELFCQ

SBF1

36

O95248
DSWPVNERYPAGNFD

NRXN2

196

P58401
AQFPRNDGDPQALWI

CHAC1

21

Q9BUX1
GNARPNNPDWGTFEE

FGA

401

P02671
FYNNRPWRPAEGQDA

LAMB3

296

Q13751
DFFQDAPWRPAADLQ

LAMB4

311

A4D0S4
FENWRENQPDNFFAG

NCAN

1166

O14594
PDNWKVPQDGDFDFL

STK3

426

Q13188
LPSNDDRAPAWFEDF

TMEM94

1211

Q12767
QGADPNARDNWNYTP

TNKS

271

O95271
FRNWNPNKPFDQALD

SPOCK1

66

Q08629
GWDPQNGFDVNNLDP

WAS

251

P42768
WEEFGNPDGPQATSF

SEC63

161

Q9UGP8
CPGQFNPVEKWFDNE

PKHD1L1

3441

Q86WI1
GWDPNTGFDLNNLDP

WASL

216

O00401