Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	CTCK_1	VWF CCN1 CCN2 SSPOP	1.01e-06	18	82	4	PS01185
Domain	Cys_knot_C	VWF CCN1 CCN2 SSPOP	4.07e-06	25	82	4	IPR006207
Domain	CTCK_2	VWF CCN1 CCN2 SSPOP	4.07e-06	25	82	4	PS01225
Domain	-	TRIM2 USP51 TRIM61 BAZ2B TRIM28 MARCHF3 PEX10 KDM2A FBXL19 TRIM36 RUFY1	4.13e-06	449	82	11	3.30.40.10
Domain	Znf_RING/FYVE/PHD	TRIM2 USP51 TRIM61 BAZ2B TRIM28 MARCHF3 PEX10 KDM2A FBXL19 TRIM36 RUFY1	5.10e-06	459	82	11	IPR013083
Domain	VWFC_1	VWF CCN1 CCN2 SSPOP	1.83e-05	36	82	4	PS01208
Domain	VWC	VWF CCN1 CCN2 SSPOP	2.27e-05	38	82	4	SM00214
Domain	VWFC_2	VWF CCN1 CCN2 SSPOP	2.27e-05	38	82	4	PS50184
Domain	VWF_dom	VWF CCN1 CCN2 SSPOP	3.40e-05	42	82	4	IPR001007
Domain	PHD_4	KDM2A FBXL19	5.70e-05	3	82	2	PF16866
Domain	CT	VWF CCN1 CCN2	1.18e-04	22	82	3	SM00041
Domain	NUT	NUTM2B NUTM2A	1.89e-04	5	82	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	1.89e-04	5	82	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	1.89e-04	5	82	2	PF12881
Domain	IGFBP_CNN	CCN1 CCN2	1.89e-04	5	82	2	IPR012395
Domain	VWC	VWF CCN1 CCN2	2.47e-04	28	82	3	PF00093
Domain	-	TRIM2 TRIM61 TRIM28 TRIM36	2.68e-04	71	82	4	4.10.45.10
Domain	zf-B_box	TRIM2 TRIM61 TRIM28 TRIM36	2.83e-04	72	82	4	PF00643
Domain	Znf_PHD-finger	BAZ2B TRIM28 KDM2A FBXL19	4.04e-04	79	82	4	IPR019787
Domain	ZF_BBOX	TRIM2 TRIM61 TRIM28 TRIM36	4.24e-04	80	82	4	PS50119
Domain	Znf_B-box	TRIM2 TRIM61 TRIM28 TRIM36	4.44e-04	81	82	4	IPR000315
Domain	zf-C3HC4	TRIM2 TRIM61 TRIM28 MARCHF3 PEX10 TRIM36	4.46e-04	223	82	6	PF00097
Domain	Znf_FYVE_PHD	BAZ2B TRIM28 KDM2A FBXL19 RUFY1	4.73e-04	147	82	5	IPR011011
Domain	Znf_RING	TRIM2 TRIM61 TRIM28 MARCHF3 PEX10 TRIM36 RUFY1	5.74e-04	326	82	7	IPR001841
Domain	PHD	BAZ2B TRIM28 KDM2A FBXL19	6.35e-04	89	82	4	SM00249
Domain	Znf_PHD	BAZ2B TRIM28 KDM2A FBXL19	6.90e-04	91	82	4	IPR001965
Domain	ZF_PHD_2	BAZ2B TRIM28 KDM2A FBXL19	8.11e-04	95	82	4	PS50016
Domain	ZF_PHD_1	BAZ2B TRIM28 KDM2A FBXL19	8.44e-04	96	82	4	PS01359
Domain	Znf_C3HC4_RING-type	TRIM2 TRIM61 MARCHF3 PEX10 TRIM36	9.62e-04	172	82	5	IPR018957
Domain	Znf_CXXC	KDM2A FBXL19	1.02e-03	11	82	2	IPR002857
Domain	ZF_CXXC	KDM2A FBXL19	1.02e-03	11	82	2	PS51058
Domain	zf-CXXC	KDM2A FBXL19	1.02e-03	11	82	2	PF02008
Domain	Insulin_GF-bd_Cys-rich_CS	CCN1 CCN2	1.02e-03	11	82	2	IPR017891
Domain	TIL	VWF SSPOP	1.22e-03	12	82	2	PF01826
Domain	IGFBP_N_1	CCN1 CCN2	1.22e-03	12	82	2	PS00222
Domain	C8	VWF SSPOP	1.22e-03	12	82	2	PF08742
Domain	Unchr_dom_Cys-rich	VWF SSPOP	1.44e-03	13	82	2	IPR014853
Domain	C8	VWF SSPOP	1.44e-03	13	82	2	SM00832
Domain	TIL_dom	VWF SSPOP	1.67e-03	14	82	2	IPR002919
Domain	Bbox_C	TRIM2 TRIM28	1.93e-03	15	82	2	IPR003649
Domain	BBC	TRIM2 TRIM28	1.93e-03	15	82	2	SM00502
Domain	Glyco_hormone_CN	CCN1 CCN2	1.93e-03	15	82	2	IPR006208
Domain	Cys_knot	CCN1 CCN2	1.93e-03	15	82	2	PF00007
Domain	VWD	VWF SSPOP	2.20e-03	16	82	2	SM00216
Domain	VWF_type-D	VWF SSPOP	2.20e-03	16	82	2	IPR001846
Domain	VWFD	VWF SSPOP	2.20e-03	16	82	2	PS51233
Domain	VWD	VWF SSPOP	2.20e-03	16	82	2	PF00094
Domain	TSP_1	CCN1 CCN2 SSPOP	2.68e-03	63	82	3	PF00090
Domain	RUN	SGSM2 RUFY1	2.78e-03	18	82	2	SM00593
Domain	IB	CCN1 CCN2	2.78e-03	18	82	2	SM00121
Domain	TSP1	CCN1 CCN2 SSPOP	2.93e-03	65	82	3	SM00209
Domain	TSP1_rpt	CCN1 CCN2 SSPOP	2.93e-03	65	82	3	IPR000884
Domain	TSP1	CCN1 CCN2 SSPOP	2.93e-03	65	82	3	PS50092
Domain	Zinc_finger_PHD-type_CS	TRIM28 KDM2A FBXL19	2.93e-03	65	82	3	IPR019786
Domain	RUN	SGSM2 RUFY1	3.10e-03	19	82	2	PS50826
Domain	VWC_out	VWF SSPOP	3.10e-03	19	82	2	SM00215
Domain	RUN	SGSM2 RUFY1	3.10e-03	19	82	2	PF02759
Domain	Run_dom	SGSM2 RUFY1	3.10e-03	19	82	2	IPR004012
Domain	Leu-rich_rpt_Cys-con_subtyp	KDM2A FBXL19	3.10e-03	19	82	2	IPR006553
Domain	LRR_CC	KDM2A FBXL19	3.10e-03	19	82	2	SM00367
Domain	F-box	FBXO40 KDM2A FBXL19	3.19e-03	67	82	3	PF00646
Domain	IGFBP-like	CCN1 CCN2	3.44e-03	20	82	2	IPR000867
Domain	IGFBP	CCN1 CCN2	3.44e-03	20	82	2	PF00219
Domain	IGFBP_N_2	CCN1 CCN2	3.44e-03	20	82	2	PS51323
Domain	BBOX	TRIM2 TRIM28 TRIM36	3.47e-03	69	82	3	SM00336
Domain	FBOX	FBXO40 KDM2A FBXL19	3.91e-03	72	82	3	PS50181
Domain	-	FURIN CUL7 SSPOP	4.07e-03	73	82	3	2.60.120.260
Domain	F-box_dom	FBXO40 KDM2A FBXL19	4.39e-03	75	82	3	IPR001810
Pubmed	Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance.	CCN1 CCN2	6.33e-06	2	88	2	15526358
Pubmed	Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).	CCN1 CCN2	6.33e-06	2	88	2	10446209
Pubmed	Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes.	VWF FURIN	6.33e-06	2	88	2	1571548
Pubmed	Atrial expression of the CCN1 and CCN2 proteins in chronic heart failure.	CCN1 CCN2	6.33e-06	2	88	2	22532143
Pubmed	Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.	VWF FURIN	6.33e-06	2	88	2	2251280
Pubmed	Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61).	CCN1 CCN2	6.33e-06	2	88	2	12831056
Pubmed	Connective tissue growth factor inhibits gastric cancer peritoneal metastasis by blocking integrin α3β1-dependent adhesion.	CCN2 ITGA3	6.33e-06	2	88	2	24985492
Pubmed	The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.	CCN1 CCN2	6.33e-06	2	88	2	9135077
Pubmed	TRIM28 Is a Novel Regulator of CD133 Expression Associated with Cancer Stem Cell Phenotype.	PROM1 TRIM28	6.33e-06	2	88	2	36077272
Pubmed	Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomas.	CCN1 CCN2	6.33e-06	2	88	2	15041728
Pubmed	Expression of CTGF and Cyr61 in colorectal cancer.	CCN1 CCN2	6.33e-06	2	88	2	21081514
Pubmed	Transcriptional and post-transcriptional regulation of CCN genes in failing heart.	CCN1 CCN2	6.33e-06	2	88	2	25712640
Pubmed	A single bout of exercise with high mechanical loading induces the expression of Cyr61/CCN1 and CTGF/CCN2 in human skeletal muscle.	CCN1 CCN2	6.33e-06	2	88	2	17673559
Pubmed	STROBE: The correlation of Cyr61, CTGF, and VEGF with polymyositis/dermatomyositis.	CCN1 CCN2	1.90e-05	3	88	2	30142763
Pubmed	YAP, CTGF and Cyr61 are overexpressed in tamoxifen-resistant breast cancer and induce transcriptional repression of ERα.	CCN1 CCN2	1.90e-05	3	88	2	34096606
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	1.90e-05	3	88	2	22456610
Pubmed	Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer.	CCN1 CCN2	1.90e-05	3	88	2	17579708
Pubmed	Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development.	CCN1 CCN2	1.90e-05	3	88	2	1419914
Pubmed	Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development.	CCN1 CCN2	1.90e-05	3	88	2	9184077
Pubmed	Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells.	CCN1 CCN2	1.90e-05	3	88	2	20056838
Pubmed	MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.	CCN1 CCN2	1.90e-05	3	88	2	24910328
Pubmed	CircUSP48 promotes malignant behavior by regulating CYR61 via miR-365 in osteosarcoma.	CCN1 USP48	1.90e-05	3	88	2	37553503
Pubmed	Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF.	CCN1 CCN2	1.90e-05	3	88	2	21349946
Pubmed	Differential expression of CCN family members CYR611, CTGF and NOV in gastric cancer and their association with disease progression.	CCN1 CCN2	1.90e-05	3	88	2	27633176
Pubmed	Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress.	CCN1 CCN2	1.90e-05	3	88	2	15053922
Pubmed	Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.	CCN1 CCN2	1.90e-05	3	88	2	11751417
Pubmed	Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells.	CCN1 CCN2	1.90e-05	3	88	2	18936953
Pubmed	Paracrine Signaling from Breast Cancer Cells Causes Activation of ID4 Expression in Tumor-Associated Macrophages.	CCN1 CCN2	1.90e-05	3	88	2	32054109
Pubmed	Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation.	CCN1 CCN2	1.90e-05	3	88	2	24485923
Pubmed	[Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma].	PROM1 ECE2	1.90e-05	3	88	2	17545092
Pubmed	Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner.	CCN1 CCN2	1.90e-05	3	88	2	17765657
Pubmed	Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells.	CCN1 CCN2	1.90e-05	3	88	2	18212329
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	1.90e-05	3	88	2	26542179
Pubmed	Mucopolysaccharidosis Type III	HGSNAT GNS	3.79e-05	4	88	2	31536183
Pubmed	Up-regulation of estrogen responsive genes in hypospadias: microarray analysis.	CCN1 CCN2	3.79e-05	4	88	2	17437852
Pubmed	Proteolytic processing of human zona pellucida proteins.	FURIN ZP2	3.79e-05	4	88	2	11804956
Pubmed	UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.	MAP7D1 KANSL2 TRIM28 TAF1C ZNF646	4.79e-05	155	88	5	34921745
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	TRIM28 CUL7 BAG6	4.90e-05	28	88	3	25752541
Pubmed	The modular architecture of a new family of growth regulators related to connective tissue growth factor.	CCN1 CCN2	6.30e-05	5	88	2	7687569
Pubmed	Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.	CCN1 CCN2	6.30e-05	5	88	2	19364818
Pubmed	Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis.	CCN2 ITGA3	6.30e-05	5	88	2	32423907
Pubmed	Elastic force restricts growth of the murine utricle.	CCN1 CCN2	6.30e-05	5	88	2	28742024
Pubmed	The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling.	CCN1 CCN2	6.30e-05	5	88	2	33195213
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	TRIM28 ASPM AMBRA1 BAG6	6.33e-05	84	88	4	29563501
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	SEPSECS CCN1 SUGP2 BAZ2B CUL7 TEX10	8.37e-05	282	88	6	23667531
Pubmed	Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).	CCN1 CCN2	9.43e-05	6	88	2	26498181
Pubmed	Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions.	CCN1 CCN2	9.43e-05	6	88	2	12036876
Pubmed	Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2.	CCN1 CCN2	1.32e-04	7	88	2	23839921
Pubmed	The tripartite motif family identifies cell compartments.	TRIM2 TRIM28 TRIM36	1.56e-04	41	88	3	11331580
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	MAP7D1 SUGP2 NUTM2B NYNRIN TNS2 RTL8C SSPOP BAG6	1.57e-04	608	88	8	16713569
Pubmed	Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.	CCN1 PCDH15	1.75e-04	8	88	2	35044843
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TRIM28 INPP5E KDM2A CCN2 PARP14 DALRD3	2.03e-04	332	88	6	37433992
Pubmed	Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation.	CCN1 CCN2	2.25e-04	9	88	2	31747096
Pubmed	Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy.	PROM1 CCN2	2.25e-04	9	88	2	36283963
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KDM2A FBXL19	2.81e-04	10	88	2	29276034
Pubmed	Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy.	NFATC3 CCN2	2.81e-04	10	88	2	27249321
Pubmed	Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development.	CCN1 CCN2	2.81e-04	10	88	2	36139407
Pubmed	The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.	CCN1 CCN2	3.43e-04	11	88	2	33483469
Pubmed	TRIM28 functions as a negative regulator of aggresome formation.	TRIM28 BAG6	4.11e-04	12	88	2	33783327
Pubmed	Cardiac mouse lymphatics: developmental and anatomical update.	PROM1 VWF	4.11e-04	12	88	2	24700724
Pubmed	A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11.	VWF ITGA3	4.11e-04	12	88	2	8986815
Pubmed	SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.	CCN1 CCN2	4.11e-04	12	88	2	34267330
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SUGP2 TRIM28 INPP5E SGSM2 FURIN AMBRA1 DISP2 ITGA3 FBXL19 ESPL1	4.82e-04	1105	88	10	35748872
Pubmed	Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage.	CCN1 CCN2	4.85e-04	13	88	2	18597638
Pubmed	Systematic analysis and nomenclature of mammalian F-box proteins.	FBXO40 KDM2A FBXL19	5.07e-04	61	88	3	15520277
Pubmed	DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.	CCN1 CCN2	5.65e-04	14	88	2	28087714
Pubmed	VGLL4 plays a critical role in heart valve development and homeostasis.	CCN1 CCN2	5.65e-04	14	88	2	30789911
Pubmed	Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.	VWF CCN2	5.65e-04	14	88	2	36347239
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	TRIM2 MARCHF3 PEX10 TRIM36	5.71e-04	149	88	4	19549727
Pubmed	Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs.	VWF CCN2	6.51e-04	15	88	2	28684544
Pubmed	HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.	FURIN ETS2	6.51e-04	15	88	2	25453830
Pubmed	The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.	NFATC3 TRIM28	6.51e-04	15	88	2	26522984
Pubmed	Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos.	VWF ITGA3	6.51e-04	15	88	2	10706142
Pubmed	The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.	SUGP2 TRIM28	6.51e-04	15	88	2	25882849
Pubmed	Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.	AHSG GNS GAA	7.90e-04	71	88	3	12754519
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	CCN1 CCN2 SSPOP	9.27e-04	75	88	3	20637190
Pubmed	Counteractive and cooperative actions of muscle β-catenin and CaV1.1 during early neuromuscular synapse formation.	CCN1 CCN2	1.05e-03	19	88	2	35340430
Pubmed	Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.	PROM1 CCN2	1.05e-03	19	88	2	25515659
Pubmed	Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts.	CCN1 CCN2	1.17e-03	20	88	2	26033091
Pubmed	Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.	CCN1 CCN2	1.17e-03	20	88	2	20133625
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	FBXO40 FBXL19 TRIM36	1.33e-03	85	88	3	19028597
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SEPSECS MAP7D1 KANSL2 SUGP2 KDM2A CUL7 TEX10 GAA	1.49e-03	857	88	8	25609649
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	P2RX7 AHSG CUL7 ZP2 GNS	1.52e-03	329	88	5	17474147
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP51 USP48	1.55e-03	23	88	2	14715245
Pubmed	Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.	TRIM28 TAF1C	1.55e-03	23	88	2	12393749
Pubmed	Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.	CCN1 CCN2	1.68e-03	24	88	2	32186512
Pubmed	Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.	CCN1 CCN2	1.68e-03	24	88	2	24043783
Pubmed	Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation.	CCN1 CCN2	1.68e-03	24	88	2	37543677
Pubmed	Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.	CCN1 CCN2	1.83e-03	25	88	2	30912742
Pubmed	A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.	SLC34A1 ITGA3	1.98e-03	26	88	2	19060336
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MAP7D1 SUGP2 TRIM28 TAF1C ASPM AMBRA1 ITGA3 CUL7 ZNF646	2.07e-03	1116	88	9	31753913
Pubmed	Transcriptome analysis in prenatal IGF1-deficient mice identifies molecular pathways and target genes involved in distal lung differentiation.	CCN1 CCN2	2.13e-03	27	88	2	24391734
Pubmed	Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme.	CCN1 CCN2	2.13e-03	27	88	2	31575647
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	SGSM2 TNS2 CCN2 CUL7	2.17e-03	214	88	4	22199357
Pubmed	A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.	CCN1 CCN2	2.29e-03	28	88	2	25912685
Pubmed	Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.	CCN1 CCN2	2.29e-03	28	88	2	24880616
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TRIM2 SSPOP ECE2	2.44e-03	105	88	3	9628581
Pubmed	Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.	FURIN BAG6	2.46e-03	29	88	2	21909115
Pubmed	LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.	CCN1 CCN2	2.46e-03	29	88	2	27358050
GeneFamily	CYR61/CTGF/NOV matricellular proteins	CCN1 CCN2	1.40e-04	6	56	2	1046
GeneFamily	PHD finger proteins	BAZ2B TRIM28 KDM2A FBXL19	1.73e-04	90	56	4	88
GeneFamily	Ring finger proteins	TRIM2 TRIM61 TRIM28 MARCHF3 PEX10 TRIM36	2.01e-04	275	56	6	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM2 TRIM61 TRIM28 TRIM36	2.13e-04	95	56	4	59
GeneFamily	Zinc fingers CXXC-type	KDM2A FBXL19	6.10e-04	12	56	2	136
GeneFamily	F-box and leucine rich repeat proteins	KDM2A FBXL19	1.91e-03	21	56	2	558
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	CCN1 SUGP2 ASPM PABPC1L CCN2 ESPL1	2.26e-06	192	88	6	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC34A1 WDR73 PPM1K TEX10 TESPA1	1.60e-05	159	88	5	74655c22e9fdd88e3052b9dfb954c8fb678bd2d8
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PLEKHG6 METRNL SIGLEC10 GNS GAA	2.68e-05	177	88	5	382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	BAZ2B ETS2 CCN2 PPM1K PARP14	3.14e-05	183	88	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SIGLEC10 SLC35E1 AMBRA1 ITGA3 ECE2	3.57e-05	188	88	5	c74771584b3ba9561a99a54bf55a9203ddf8eff8
ToppCell	368C-Epithelial_cells-Epithelial-I_(AT1)\|368C / Donor, Lineage, Cell class and subclass (all cells)	SIGLEC10 SLC35E1 AMBRA1 ITGA3 ECE2	3.57e-05	188	88	5	9155b9a92496e75646778c025b02947e9e9ec73a
ToppCell	Entopeduncular-Endothelial\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	STON1 CCN1 TNS2 CCN2 PARP14	3.57e-05	188	88	5	94774652fd42bad5012356672ffac8b6d2c22d37
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CSF3R SIGLEC10 ETS2 PARP14 GAA	3.76e-05	190	88	5	4498705c5c1c7ba88a26fd2f412cf1aadd0f572a
ToppCell	LAM-Epithelial-AT1\|Epithelial / Condition, Lineage and Cell class	CCN1 METRNL CCN2 ITGA3 PARP14	3.85e-05	191	88	5	3457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCell	Caecum-(6)_Macrophage-(61)_LYVE1_Macrophage\|Caecum / shred on region, Cell_type, and subtype	NWD1 CSF3R SSPOP RAB3IL1 GNS	4.57e-05	198	88	5	e684c3934c163aef4d284b69435832d2c9614f2a
ToppCell	Caecum-Macrophage-LYVE1_Macrophage\|Caecum / Region, Cell class and subclass	NWD1 CSF3R SSPOP RAB3IL1 GNS	4.57e-05	198	88	5	a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CSF3R BAZ2B METRNL ETS2 GNS	4.57e-05	198	88	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	distal-Endothelial-Bronchial_Vessel_2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VWF CCN1 ELFN1 ETS2 CCN2	4.68e-05	199	88	5	bd9090c13a38a35d50f676fdf11b68eec1340bd3
ToppCell	distal-Endothelial-Bronchial_Vessel_2-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VWF CCN1 ELFN1 ETS2 CCN2	4.68e-05	199	88	5	ddd6cad854d889d58c1e6bbcdfd96edce4fc9694
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	IGHA1 FURIN ITGA3 USP48 GNS	4.79e-05	200	88	5	0d76b006d8e8b32174e65e400acd0674354b962c
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	IGHA1 FURIN ITGA3 USP48 GNS	4.79e-05	200	88	5	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCell	control-Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CSF3R P2RX7 BAZ2B GNS GAA	4.79e-05	200	88	5	b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCN1 BAZ2B TNS2 RTL8C MYO16	4.79e-05	200	88	5	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CSF3R BAZ2B METRNL GNS GAA	4.79e-05	200	88	5	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell	TCGA-Ovary-Primary_Tumor\|TCGA-Ovary / Sample_Type by Project: Shred V9	VWF CCN1 NYNRIN CCN2	5.83e-05	106	88	4	14f548be39cec604fbdae0382cbf434fa4049840
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma\|TCGA-Ovary / Sample_Type by Project: Shred V9	VWF CCN1 NYNRIN CCN2	5.83e-05	106	88	4	939b80950d39cdc7149a05fdfb64c8810064cdb1
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma\|TCGA-Ovary / Sample_Type by Project: Shred V9	VWF CCN1 NYNRIN CCN2	5.83e-05	106	88	4	e9e1b55f32b3d5b9eeec94a997912e5c21c1fb48
Drug	Cefuroxime sodium salt [56238-63-2]; Down 200; 9uM; MCF7; HT_HG-U133A	CCN1 SUGP2 INPP5E SGSM2 FPGS TAF1C ETS2 KDM2A	7.03e-07	198	84	8	6261_DN
Drug	Ticarcillin sodium [4697-14-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	SUGP2 NFATC3 AMBRA1 TNS2 RAB3IL1 GNS GAA	8.42e-06	197	84	7	7185_DN
Drug	AG-013608 [351320-38-2]; Down 200; 10uM; PC3; HT_HG-U133A	PROM1 CCN1 NFATC3 TAF1C TNS2 CCN2 CUL7	8.99e-06	199	84	7	5949_DN
Disease	mucopolysaccharidosis III (implicated_via_orthology)	HGSNAT GNS	4.90e-05	4	85	2	DOID:12801 (implicated_via_orthology)
Disease	MPS III D	HGSNAT GNS	4.90e-05	4	85	2	C0086650
Disease	MPS III C	HGSNAT GNS	4.90e-05	4	85	2	C0086649
Disease	MPS III B	HGSNAT GNS	4.90e-05	4	85	2	C0086648
Disease	Mucopolysaccharidosis Type IIIA	HGSNAT GNS	4.90e-05	4	85	2	C0086647
Disease	Sanfilippo syndrome	HGSNAT GNS	4.90e-05	4	85	2	cv:C0026706
Disease	Mucopolysaccharidosis III	HGSNAT GNS	4.90e-05	4	85	2	C0026706
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	8.15e-05	5	85	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.22e-04	6	85	2	C0334488
Disease	preeclampsia, hypertension, pregnancy-induced	FURIN TNS2	9.59e-04	16	85	2	EFO_0000668, MONDO_0024664
Disease	Systemic Scleroderma	CCN1 CCN2	1.36e-03	19	85	2	C0036421
Disease	coagulation factor measurement	VWF ASPM	1.51e-03	20	85	2	EFO_0004634
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	TDRD15 AHSG MAU2	1.99e-03	86	85	3	EFO_0008595, EFO_0020945

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSLSSSSPCLPPSHC	nan	211	Q6ZR03
SLCSCVFPLHSPTRP	nan	36	Q6ZS49
IHTRPCLDSVLGPCL	ADAD2	441	Q8NCV1
NHTCLTICLPRLPSP	ELFN1	391	P0C7U0
CSSDSPPRPSSCLLI	nan	246	Q9N2K0
SDLRCNLACTPPRHL	BAG6	341	P46379
SLLPRTPCDDTSLTH	BAZ2B	1561	Q9UIF8
LHLTRLALSTCPAAC	CCN1	16	O00622
CSRCSGTRVPSLLPH	AMBRA1	311	Q9C0C7
CHLEPCLPKETLDSS	CASP8AP2	801	Q9UKL3
SPERSCSLHSCPLED	DISP2	51	A7MBM2
CSLHSCPLEDPSSSS	DISP2	56	A7MBM2
CHGATCLPLSVRRST	ASPM	231	Q8IZT6
SCLLRQCTAPVLPHT	FBXL19	71	Q6PCT2
QCTAPVLPHTAVCLL	FBXL19	76	Q6PCT2
LNCPPRVHLILSACS	NWD1	456	Q149M9
RHKSTSSTLCPAVCP	RAB3IL1	191	Q8TBN0
PTCHSSTSEPRCSRF	PPM1K	36	Q8N3J5
PLCTLCLEERRHPTA	PEX10	271	O60683
LSSHPGLTTTCCSRR	KCND3	536	Q9UK17
HSCSPPCLSTSLQEI	INPP5E	126	Q9NRR6
CSSLPPHLFSCVERA	MYO16	466	Q9Y6X6
RVTCPHLRSISGLCS	ECE2	71	P0DPD6
RPAVLDPALCTATSC	ITGA3	476	P26006
VASICHTLNPRTCLP	CUL7	1401	Q14999
HDSANCELPLLTPCS	ETS2	61	P15036
LHVHCPTLESCILEP	MANSC4	96	A6NHS7
LHELSAPCRPCSDTE	METRNL	181	Q641Q3
RPLLPCKCSSAAHST	PABPC1L	501	Q4VXU2
HLITRATLCCARPEP	SLC34A1	591	Q06495
LCHSSLLDHLLTECP	PARP14	481	Q460N5
QCVSSALLVHCPSPT	PLEKHG6	481	Q3KR16
CSLELSPSRPCVLHS	PCDH15	1696	Q96QU1
SCLPSQLPESHRCLE	P2RX7	481	Q99572
SCHITQLLLTLGCPS	ESPL1	816	Q14674
IPNFLSHSPTCDCSL	ESPL1	1136	Q14674
LRQCLAPRLPHSVTC	KDM2A	606	Q9Y2K7
SCEPQPLEHSSCLST	LINC00322	66	Q6ZN03
ETTCHVLDPTPVARC	AHSG	86	P02765
RCCTPHRTTTLPVEF	CCN2	291	P29279
LTDCLSCPSHASLDP	FURIN	656	P09958
SCCHPRLSLHRPALE	IGHA1	121	P01876
GLSDSIRSCCLIPPH	CRYGB	71	P07316
PLCNTTELSCTFHLP	CSF3R	386	Q99062
PPCSHRLLAVCALVS	GAA	6	P10253
PVEPNTSCLVISCHL	FBXO40	26	Q9UH90
VPSALCCPSRASILT	GNS	86	P15586
CSHLPEVLPDCTSSA	MARCHF3	6	Q86UD3
TPCSVTRSVHRCAPA	MAP7D1	371	Q3KQU3
HPLRPSCPLLVCRST	DND1	121	Q8IYX4
PPHTCSASSLVFSCI	FPGS	506	Q05932
LSCAFTHRPCSHPRL	KANSL2	26	Q9H9L4
KPVPEHCASERSCLS	HGSNAT	396	Q68CP4
QRVLLHCPALRSSPC	DALRD3	116	Q5D0E6
HCPALRSSPCALRLS	DALRD3	121	Q5D0E6
PLRSCSLPRSACLCS	RTL8C	51	O15255
FRTSSPPKIRLCVHC	MAU2	36	Q9Y6X3
HISPSLASLRPVRCC	FTMT	11	Q8N4E7
CPSLSEEILRCLSLH	NYNRIN	1031	Q9P2P1
SCLKRHTPSLLLPSS	NUTM2A	21	Q8IVF1
SCLKRHTPSLLLPSS	NUTM2B	21	A6NNL0
SCLKRHTPSLLLPSS	NUTM2E	21	B1AL46
CSPCSRELILHTPPA	TRIM36	496	Q9NQ86
HLCTAPLSQQRLCPD	SSPOP	4596	A2VEC9
SFPCSLTCLHSPDRD	TDRD15	351	B5MCY1
CLPPTLHLVCTQFSL	TAF1C	451	Q15572
PKPVRVCDSCHTLLL	RUFY1	686	Q96T51
RCHPLPCILDSSLLK	FAM178B	271	Q8IXR5
LCLVHPSSETCNSIR	PROM1	306	O43490
TPSHCSCIPDRLPLR	SGSM2	471	O43147
RTSVCRHSSCPAPGL	SEBOX	121	Q9HB31
PFPVTVSLCHILALC	SLC35E1	56	Q96K37
LSVPARSHSSLSPCV	TBX10	266	O75333
DLELLCPRCSLSTDH	TRIM61	111	Q5EBN2
SIPLRCHSSSSPVCP	USP51	86	Q70EK9
CLVPDSSHCQVLLLP	VWF	2131	P04275
SSLLPTRPTCLSHAL	STON1	121	Q9Y6Q2
APAHQSLPTRLVCAC	WDR97	436	A6NE52
ELCPSICFTSSPHNL	SUGP2	836	Q8IX01
PSLSCSDCQRHFPSL	ZNF646	6	O15015
LSAPSSLICHSLCDP	NFATC3	986	Q12968
PSLPADLLSRLSRCC	TEX10	626	Q9NXF1
SLLRCHQLCAASLPP	nan	121	Q5W150
SLLTSSPPLEGCCHR	ZNF252P-AS1	106	Q0IIN9
ELGPDCILCIHSTTS	SEPSECS	211	Q9HD40
TLDSNPKVPCCTHSL	TESPA1	381	A2RU30
VEFTPLPTCLQHRSC	PLXDC1	296	Q8IUK5
IPAHSLTLSCPVCRQ	TRIM2	51	Q9C040
SCAVHPSPEAVTLLC	VSIG10L2	336	P0DP72
LCLVCVTHSSPPARL	SIGLEC10	376	Q96LC7
STPTKPIDNHACLCS	USP48	501	Q86UV5
DSPLCSVTCPVSSRH	ZP2	626	Q05996
QHSISPISLPCCLRI	TNS2	1231	Q63HR2
CLLDPRDLCHPVSSV	WDR73	251	Q6P4I2
THACCLSPSLIRSEV	TMEM39B	261	Q9GZU3
REPRLLPCLHSACSA	TRIM28	76	Q13263